Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OAZ1 Gene

Aliases for OAZ1 Gene

  • Ornithine Decarboxylase Antizyme 1 2 3
  • Antizyme 1 2 3
  • ODC-Az 3 4
  • OAZ 3 4
  • AZI 3

External Ids for OAZ1 Gene

Previous HGNC Symbols for OAZ1 Gene

  • OAZ

Previous GeneCards Identifiers for OAZ1 Gene

  • GC19P002332
  • GC19P002209
  • GC19P002220
  • GC19P002040

Summaries for OAZ1 Gene

Entrez Gene Summary for OAZ1 Gene

  • The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for OAZ1 Gene

OAZ1 (Ornithine Decarboxylase Antizyme 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of amino acids and derivatives. GO annotations related to this gene include ornithine decarboxylase inhibitor activity. An important paralog of this gene is OAZ2.

UniProtKB/Swiss-Prot for OAZ1 Gene

  • Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.

Gene Wiki entry for OAZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAZ1 Gene

Genomics for OAZ1 Gene

Regulatory Elements for OAZ1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OAZ1 Gene

Start:
2,269,509 bp from pter
End:
2,273,490 bp from pter
Size:
3,982 bases
Orientation:
Plus strand

Genomic View for OAZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OAZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAZ1 Gene

Proteins for OAZ1 Gene

  • Protein details for OAZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54368-OAZ1_HUMAN
    Recommended name:
    Ornithine decarboxylase antizyme 1
    Protein Accession:
    P54368
    Secondary Accessions:
    • O43382
    • Q14989
    • Q92595
    • Q9UPL9

    Protein attributes for OAZ1 Gene

    Size:
    228 amino acids
    Molecular mass:
    25406 Da
    Quaternary structure:
    • Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts with AZIN2; the interaction stabilizes the complex by inhibiting AZIN2 ubiquitination and degradation and leads to increased ornithine decarboxylase (ODC) activity and decreased rate of ODC1 degradation.
    SequenceCaution:
    • Sequence=BAA11374.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for OAZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAZ1 Gene

Proteomics data for OAZ1 Gene at MOPED

Post-translational modifications for OAZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAZ1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OAZ1 Gene

Domains for OAZ1 Gene

Protein Domains for OAZ1 Gene

Suggested Antigen Peptide Sequences for OAZ1 Gene

Graphical View of Domain Structure for InterPro Entry

P54368

UniProtKB/Swiss-Prot:

OAZ1_HUMAN :
  • P54368
Family:
  • Belongs to the ODC antizyme family.
genes like me logo Genes that share domains with OAZ1: view

No data available for Gene Families for OAZ1 Gene

Function for OAZ1 Gene

Molecular function for OAZ1 Gene

GENATLAS Biochemistry: ornithine decarboxylase antizyme 1,expressed in the liver,programming ribosomal frameshifting,modulating the rate of ODC degradation
UniProtKB/Swiss-Prot Function: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.

Gene Ontology (GO) - Molecular Function for OAZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity --
GO:0005515 protein binding IPI 17900240
GO:0008073 ornithine decarboxylase inhibitor activity ISS --
genes like me logo Genes that share ontologies with OAZ1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OAZ1 Gene

Localization for OAZ1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OAZ1 Gene COMPARTMENTS Subcellular localization image for OAZ1 gene
Compartment Confidence
cytosol 4
mitochondrion 2
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for OAZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OAZ1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OAZ1 Gene

Pathways for OAZ1 Gene

genes like me logo Genes that share pathways with OAZ1: view

Pathways by source for OAZ1 Gene

1 Qiagen pathway for OAZ1 Gene
2 BioSystems pathways for OAZ1 Gene

Interacting Proteins for OAZ1 Gene

Gene Ontology (GO) - Biological Process for OAZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006521 regulation of cellular amino acid metabolic process TAS --
GO:0006596 polyamine biosynthetic process IEA --
GO:0006810 transport IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with OAZ1: view

Compounds for OAZ1 Gene

(6) HMDB Compounds for OAZ1 Gene

Compound Synonyms Cas Number PubMed IDs
N1-Acetylspermine
  • N'-Acetylspermine
25593-72-0
Norspermidine
  • N-(3-aminopropyl)-1,3-Propanediamine
56-18-8
Ornithine
  • (+)-S-Ornithine
70-26-8
Putrescine
  • 1,4-Butanediamine
110-60-1
Spermidine
  • 1,5,10-Triazadecane
124-20-9

(1) Drugbank Compounds for OAZ1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Ornithine
  • (S)-2,5-Diaminopentanoate
70-26-8 target

(5) Novoseek inferred chemical compound relationships for OAZ1 Gene

Compound -log(P) Hits PubMed IDs
ornithine 88.7 35
putrescine 69.6 1
spermidine 60.7 1
spermine 53.8 1
s-adenosylmethionine 44.6 1
genes like me logo Genes that share compounds with OAZ1: view

Transcripts for OAZ1 Gene

Unigene Clusters for OAZ1 Gene

Ornithine decarboxylase antizyme 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OAZ1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OAZ1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - -
SP6: - -
SP7: - - - -
SP8: -
SP9: - -

Relevant External Links for OAZ1 Gene

GeneLoc Exon Structure for
OAZ1
ECgene alternative splicing isoforms for
OAZ1

Expression for OAZ1 Gene

mRNA expression in normal human tissues for OAZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAZ1 Gene

This gene is overexpressed in Whole Blood (7.8).

SOURCE GeneReport for Unigene cluster for OAZ1 Gene Hs.446427

genes like me logo Genes that share expressions with OAZ1: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for OAZ1 Gene

Orthologs for OAZ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OAZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAZ1 35
  • 100 (n)
  • 100 (a)
OAZ1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OAZ1 35
  • 91.92 (n)
  • 91.19 (a)
OAZ1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OAZ1 35
  • 92.66 (n)
  • 91.63 (a)
OAZ1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oaz1 35
  • 85.93 (n)
  • 84.86 (a)
Oaz1 16
Oaz1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OAZ1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oaz1 35
  • 85.93 (n)
  • 84.86 (a)
chicken
(Gallus gallus)
Aves OAZ 36
  • 86 (a)
OneToOne
OAZ1 35
  • 84.06 (n)
  • 86.47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia oaz1 35
  • 78.63 (n)
  • 80.92 (a)
zebrafish
(Danio rerio)
Actinopterygii oaz1a 35
  • 67.98 (n)
  • 67.98 (a)
oaz1a 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Oda 36
  • 21 (a)
OneToMany
Species with no ortholog for OAZ1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OAZ1 Gene

ENSEMBL:
Gene Tree for OAZ1 (if available)
TreeFam:
Gene Tree for OAZ1 (if available)

Paralogs for OAZ1 Gene

Paralogs for OAZ1 Gene

Selected SIMAP similar genes for OAZ1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for OAZ1 Gene

genes like me logo Genes that share paralogs with OAZ1: view

Variants for OAZ1 Gene

Sequence variations from dbSNP and Humsavar for OAZ1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4667 - 2,269,693(+) CAGCC(G/T)CACCA reference, missense
rs13140 -- 2,273,147(+) GCCAC(C/T)CCTTG utr-variant-3-prime
rs1057150 -- 2,273,080(+) CGAGA(A/G/T)AGAGT missense, reference
rs1057230 -- 2,273,094(+) CGGGA(A/G)AGGAG missense, reference
rs1058173 -- 2,273,410(+) ACAGT(C/T)TTAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OAZ1 Gene

Variant ID Type Subtype PubMed ID
dgv3614n71 CNV Loss 21882294
dgv3622n71 CNV Loss 21882294
nsv910623 CNV Loss 21882294
dgv3629n71 CNV Loss 21882294
dgv3630n71 CNV Loss 21882294
dgv3631n71 CNV Loss 21882294
nsv833707 CNV Loss 17160897
nsv910636 CNV Loss 21882294
dgv3633n71 CNV Loss 21882294
nsv910643 CNV Loss 21882294
dgv3635n71 CNV Loss 21882294
nsv910646 CNV Loss 21882294

Relevant External Links for OAZ1 Gene

HapMap Linkage Disequilibrium report
OAZ1
Human Gene Mutation Database (HGMD)
OAZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAZ1 Gene

Disorders for OAZ1 Gene

(1) Novoseek inferred disease relationships for OAZ1 Gene

Disease -log(P) Hits PubMed IDs
tumors 2.58 7

Relevant External Links for OAZ1

Genetic Association Database (GAD)
OAZ1
Human Genome Epidemiology (HuGE) Navigator
OAZ1
genes like me logo Genes that share disorders with OAZ1: view

No data available for UniProtKB/Swiss-Prot for OAZ1 Gene

Publications for OAZ1 Gene

  1. Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme. (PMID: 7811704) Tewari D.S. … Tewari M. (Biochim. Biophys. Acta 1994) 2 3 4 23
  2. Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization. (PMID: 8954789) Matsufuji S. … Hayashi S. (Genomics 1996) 2 3 23
  3. Molecular cloning of human antizyme cDNA. (PMID: 9132164) Yang D. … Onozaki K. (Biochem. Mol. Biol. Int. 1996) 3 4 23
  4. Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events. (PMID: 17761941) Dumont J. … Brousseau T. (Arterioscler. Thromb. Vasc. Biol. 2007) 3 23 48
  5. Proteasomal degradation of Smad1 induced by bone morphogenetic proteins. (PMID: 11571290) Gruendler C. … Wang T. (J. Biol. Chem. 2001) 3 23

Products for OAZ1 Gene

Sources for OAZ1 Gene

Back to Top

Content