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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OAZ1 Gene

protein-coding   GIFtS: 65
GCID: GC19P002269

ornithine decarboxylase antizyme 1


(Previous symbol: OAZ)
 Explore 15 diseases affiliated with
OAZ1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OAZ1    

Aliases
for OAZ1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ornithine Decarboxylase Antizyme 11 2
OAZ1 2 3
AZI1 2
ODC-Az2 3
MGC1383381
Antizyme 12

External Ids:    HGNC: 80951   Entrez Gene: 49462   Ensembl: ENSG000001049047   OMIM: 6015795   UniProtKB: P543683   

Export aliases for OAZ1 gene to outside databases

Previous GC identifers: GC19P002332 GC19P002209 GC19P002220 GC19P002040


Summaries
for OAZ1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OAZ1:
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting
step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine
synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by
polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and
accelerates its degradation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368
Function: Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of
polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the
CREBBP/EP300 repressor SNIP1

Gene Wiki entry for OAZ1


Genomic Views
for OAZ1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OAZ1 gene promoter:
         Pax-5   p53   SREBP-1c   MyoD   STAT5A   SREBP-1b   HEN1   CREB   SREBP-1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OAZ1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OAZ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OAZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

OAZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAZ1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P002269:  view genomic region     (about GC identifiers)

Start:
 2,269,519 bp from pter      End:
 2,273,487 bp from pter
Size:
 3,969 bases      Orientation:
 plus strand

Proteins
for OAZ1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368 (See protein sequence)
Recommended Name: Ornithine decarboxylase antizyme 1  
Size: 228 amino acids; 25406 Da
Subunit: Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome
Sequence caution: Sequence=BAA11374.1; Type=Erroneous initiation;
Secondary accessions: O43382 Q14989 Q92595 Q9UPL9
Ribosomal frameshifting: 1 isoform:  P54368-1   

Explore the universe of human proteins at neXtProt for OAZ1: NX_P54368

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54368

    • OAZ1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004143.1  
    ENSEMBL proteins: 
     ENSP00000463955   ENSP00000464146   ENSP00000467452   ENSP00000468437   ENSP00000466770  
     ENSP00000314813  
    Reactome Protein details: P54368
    Human Recombinant Protein Products: 
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    Novus Biologicals OAZ1 Lysate
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    ProSpec Recombinant Protein for OAZ1
    Uscn Proteins for OAZ1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    OAZ1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for OAZ1

    Protein Domains /
    Families
    for OAZ1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OAZ1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002993 ODC_AZ
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry P54368

    ProtoNet protein and cluster: P54368

    1 Blocks protein family: IPB002993 Ornithine decarboxylase antizyme

    UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368
    Similarity: Belongs to the ODC antizyme family


    Function
    for OAZ1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368
    Function: Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of
    polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the
    CREBBP/EP300 repressor SNIP1

         Genatlas biochemistry entry for OAZ1:
    ornithine decarboxylase antizyme 1,expressed in the liver,programming ribosomal frameshifting,modulating the rate of
    ODC degradation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OAZ1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate OAZ1 (see all 20):
    hsa-miR-548j hsa-miR-16-2* hsa-miR-548i hsa-miR-3942-5p hsa-miR-16-1* hsa-miR-507 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: OAZ1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OAZ1 (see all 7)
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    Gene Editing
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    Search LifeMap BioReagents cell lines for OAZ1

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008073ornithine decarboxylase inhibitor activity IEA--


    OAZ1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for OAZ1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    		26S proteosome degrades ODC holoenzyme complex0.83
    		Regulation of ornithine decarboxylase (ODC)0.80
    2Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00
    3Nucleotide Metabolism
    		Nucleotide Metabolism1.00
    4Aurora A signaling
    		Aurora A signaling1.00
    5Metabolism
    		Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for OAZ1
        BMP Pathway

    2 BioSystems Pathways for OAZ1 
        Nucleotide Metabolism
    Aurora A signaling

    4        Reactome Pathways for OAZ1
        26S proteosome degrades ODC holoenzyme complex
    Regulation of ornithine decarboxylase (ODC)
    Metabolism
    Metabolism of amino acids and derivatives



    OAZ1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OAZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for OAZ1 (P543682, 3 ENSP000003148134) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2861439 I2D: score=3 STRING: ENSP00000244769
    AZI1Q9UPN43, ENSP000003935834I2D: score=1 STRING: ENSP00000393583
    PSMB4P280703, ENSP000002905414I2D: score=1 STRING: ENSP00000290541
    OAZ3Q9UMX23, ENSP000003139224I2D: score=1 STRING: ENSP00000313922
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006521regulation of cellular amino acid metabolic process TAS--
    GO:0006596polyamine biosynthetic process TAS7813017
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--


    OAZ1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OAZ1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OAZ1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OAZ1

    6 HMDB Compounds for OAZ1    About this table
    CompoundSynonyms CAS #PubMed Ids
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Ornithine(+)-S-Ornithine (see all 9)70-26-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    1 DrugBank Compound for OAZ1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Ornithine(S)-2,5-Diaminopentanoate (see all 4)70-26-8target--15009201 16916800 16354653

    5 Novoseek chemical compound relationships for OAZ1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ornithine 88.7 55 7811704 (2), 8001569 (2), 12426106 (2), 9692545 (2) (see all 29)
    putrescine 69.6 1 11171097 (1)
    spermidine 60.7 4 18974881 (1)
    spermine 53.8 4 18974881 (1)
    s-adenosylmethionine 44.6 4 18974881 (1)

    Search CenterWatch for drugs/clinical trials and news about OAZ1 

    Transcripts
    for OAZ1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OAZ1 gene: 
    NM_004152.2  

    Unigene Cluster for OAZ1:

    Ornithine decarboxylase antizyme 1
    Hs.446427  [show with all ESTs]
    Unigene Representative Sequence: BC035151
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582888 ENST00000583542(uc002lvk.3 uc002lvl.3) ENST00000581150
    ENST00000592787 ENST00000590943 ENST00000588673 ENST00000593012 ENST00000586054
    ENST00000589361 ENST00000592727 ENST00000589739 ENST00000322297

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate OAZ1 (see all 20):
    hsa-miR-548j hsa-miR-16-2* hsa-miR-548i hsa-miR-3942-5p hsa-miR-16-1* hsa-miR-507 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: OAZ1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OAZ1 (see all 7)
    OriGene shRNA RFP: OAZ1
    OriGene siRNA: OAZ1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OAZ1
    Clone
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    Additional cDNA sequence: 

    AF090094.1 AK307221.1 BC007247.1 BC010063.1 BC013037.2 BC035151.1 BC042364.1 BC053360.1 
    BC055397.1 BC081537.1 BC093652.1 BC100291.1 BC112133.1 D78361.1 D87914.1 U09202.1 

    24/47 DOTS entries (see all 47):

    DT.100881247  DT.121414371  DT.91999328  DT.100039595  DT.121414664  DT.121414420  DT.454368  DT.100881250 
    DT.97774110  DT.97793139  DT.95338347  DT.91999868  DT.101958942  DT.95338331  DT.100881245  DT.100764895 
    DT.100674595  DT.121414845  DT.121414442  DT.100881236  DT.100881254  DT.95322781  DT.95338340  DT.100881253 

    24/2012 AceView cDNA sequences (see all 2012):

    BF725743 BM894249 BU163888 BQ949486 BU782696 BI909534 AW088892 BQ058055 
    BQ938178 CB105971 BU682286 BM968707 BU734089 BM916454 BM312069 AI270366 
    BU730587 AA341848 BE269266 BQ926605 BQ653077 CF126197 BM997240 BM423573 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for OAZ1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
    SP1:              -     -                             -     -                                             
    SP2:              -     -                             -     -                                             
    SP3:              -     -                             -     -                                             
    SP4:              -     -                             -                                                   
    SP5:              -     -     -     -                 -     -                                             


    ECgene alternative splicing isoforms for OAZ1

    Expression
    for OAZ1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OAZ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTAATCGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OAZ1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OAZ1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OAZ1

    SOURCE GeneReport for Unigene cluster: Hs.446427
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    In Situ
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    Orthologs
    for OAZ1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for OAZ1 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Oaz11 , 5 ornithine decarboxylase antizyme 11, 5 85.61(n)1
    84.14(a)1    		   10 (39.72 cM)5
    182451  NM_008753.41  NP_032779.21 
     808266825 
    chicken
    (Gallus gallus)    		 Aves OAZ11 ornithine decarboxylase antizyme 1 82.72(n)
    85.65(a)    		   395746  NM_204916.1  NP_990247.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii oaz1a1 ornithine decarboxylase antizyme 1a 69.33(n)
    68.54(a)    		   259192  NM_194264.2  NP_919240.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Oda6
    		 Ornithine decarboxylase antizyme
    		 23(a)
    		 1 → many
    		 2R(8054077-8061767)


    ENSEMBL Gene Tree for OAZ1 (if available)
    TreeFam Gene Tree for OAZ1 (if available) 

    Paralogs
    for OAZ1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OAZ1 gene
    OAZ22  OAZ32  
    2 SIMAP similar genes for OAZ1 using alignment to 6 protein entries:     OAZ1_HUMAN (see all proteins):
    OAZ2    OAZ3

    OAZ1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OAZ1
    PGOHUM00000244684


    Genomic Variants
    for OAZ1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 NCBI SNPs in OAZ1 are shown (see all 156)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs621196681,2
    		C,--2267526(+) GCCTCA/GGCCTC 1 -- us2k12Minor allele frequency- G:0.25NA WA 4
    rs561371041,2
    		C,--2267556(+) GGCGTA/GAGCCA 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs621197041,2
    		C,F,--2267563(+) GCCACT/CGTGCC 1 -- us2k13Minor allele frequency- C:0.33NA CSA 6
    rs1806997381,2
    		--2267586(+) AAACTC/TCTAAT 1 -- us2k10--------
    rs104075511,2
    		C--2267628(+) GCTCCT/GGGGAT 1 -- us2k12Minor allele frequency- G:0.00NA 4
    rs771080541,2
    		--2267875(+) CTCACC/TCAGGG 1 -- us2k10--------
    rs25231691,2
    		C,F,A,H,--2267939(+) GTCACG/AACTGG 1 -- us2k111Minor allele frequency- A:0.37NS NA WA EA 518
    rs283597541,2
    		C,F,--2267978(+) GCCAGG/TGACGC 1 -- us2k16Minor allele frequency- T:0.17NS WA CSA NA 418
    rs1858525191,2
    		--2267995(+) GCGCCC/TTGCAG 1 -- us2k10--------
    rs129857771,2
    		C,F,A,H,--2268055(+) ACACCC/TGAATA 1 -- us2k138Minor allele frequency- T:0.38NS EA NA WA CSA 4036

    HapMap Linkage Disequilibrium report for OAZ1 (2269519 - 2273487 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for OAZ1
         1 CNV: 5068
    Human Gene Mutation Database (HGMD): OAZ1

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    Disorders / Diseases
    for OAZ1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OAZ1 for disorders           About GeneDecksing

    OMIM gene information: 601579    OMIM disorders: --

    15 diseases for OAZ1:    About MalaCards
    bronchiolitis obliterans    systemic lupus erythematosus    lupus erythematosus    lupus nephritis
    gastroparesis    nephritis    oral cancer    bronchiolitis
    ovarian cancer    prostate cancer    ataxia    neuroblastoma
    prostatitis    pancreatitis    neuronitis

    1 Novoseek disease relationship for OAZ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 2.58 7 12888889 (3), 9692545 (2), 16847581 (1), 15009201 (1)

    Genetic Association Database (GAD): OAZ1
    Human Genome Epidemiology (HuGE) Navigator: OAZ1 (2 documents)

    Export disorders for OAZ1 gene to outside databases

    Publications
    for OAZ1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OAZ1 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with OAZ1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme. (PubMed id 7811704)1, 2, 3, 9 Tewari D.S....Tewari M. (1994)
    2. Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization. (PubMed id 8954789)1, 3, 9 Matsufuji S....Hayashi S. (1996)
    3. Molecular cloning of human antizyme cDNA. (PubMed id 9132164)1, 2, 9 Yang D.... Onozaki K. (1996)
    4. [Variations within OLF1/EBF-associated zinc finger protein gene confer susceptibility to lupus nephritis in Chinese population] (PubMed id 16061000)1, 4 Liang D....Qian J. (2005)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. Characterization of the human antizyme gene. (PubMed id 9426243)1, 2 Hayashi T.... Hayashi S. (1997)
    7. A unified pathway for the degradation of ornithine decarboxylase in reticulocyte lysate requires interaction with the polyamine-induced protein, ornithine decarboxylase antizyme. (PubMed id 8001569)1, 9 Mamroud-Kidron E....Kahana C. (1994)
    8. Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events. (PubMed id 17761941)1, 9 Dumont J....Brousseau T. (2007)
    9. Structure and promoter activity of the gene encoding ornithine decarboxylase antizyme expressed exclusively in haploid germ cells in testis (OAZt/Oaz3). (PubMed id 12426106)1, 9 Ike A....Nozaki M. (2002)
    10. Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. (PubMed id 17630775)1, 9 Tsuji T....Hu G.F. (2007)

    External Searches for OAZ1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OAZ1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4946 HGNC: 8095 AceView: OAZ1 Ensembl:ENSG00000104904 euGenes: HUgn4946
    ECgene: OAZ1 H-InvDB: OAZ1

    Other Databases showing OAZ1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OAZ1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OAZ1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/oaz1/

    Intellectual Property
    for OAZ1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OAZ1 gene:
    Search GeneIP for patents involving OAZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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