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Aliases & Descriptions for OAZ1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AZI 1 , 2 MGC138338 1 , 2 OAZ 2 , 3 ODC-Az 3
Descriptions antizyme 1 2 ornithine decarboxylase antizyme 1 2
Search outside databases for aliases for OAZ1 genePrevious GC identifers: GC19P002332 GC19P002209
Summaries for OAZ1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for OAZ1 : Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first andapparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymesplay a role in the regulation of polyamine synthesis by binding to and inhibiting ornithinedecarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translationalframeshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and acceleratesits degradation. [provided by RefSeq] UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368 Function : Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibitscellular uptake of polyamines by inactivating the polyamine uptake transporter
Gene Wiki entry for OAZ1
Genomic Location for OAZ1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the OAZ1 gene Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3 OAZ1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P002220:
(about GC identifiers )
Start:
2,220,520 bp from pter
End:
2,224,487 bp from pter
Size:
3,968 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000019.8 NT_011255.14 Proteins for OAZ1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
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Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
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R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368 (See
protein sequence )Recommended Name: Ornithine decarboxylase antizyme Size : 228 amino acids; 25406 Da
Secondary accessions : O43382 Q14989 Q92595 Q9UPL9Ribosomal frameshifting : 1 isoform : P54368-1 (A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines)
REFSEQ proteins: NP_004143.1 ENSEMBL proteins: ENSP00000314813 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for OAZ1: Assays for OAZ1:
Protein
Domains/ Families for OAZ1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P54368 ProtoNet protein and cluster: P54368
1 Blocks protein family : IPB002993 Ornithine decarboxylase antizyme UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368 Similarity : Belongs to the ODC antizyme family
Gene Function for OAZ1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004152 Applied Biosystems Silencer ® siRNAs for OAZ1 Sigma-Aldrich siRNA for OAZ1 Sigma-Aldrich shRNA for OAZ1 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004152                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004152                                  untagged cDNA clone in CMV expression vector: NM_004152  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004152 UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368 Function : Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibitscellular uptake of polyamines by inactivating the polyamine uptake transporter
Genatlas biochemistry entry for OAZ1 :ornithine decarboxylase antizyme 1,expressed in the liver,programming ribosomalframeshifting,modulating the rate of ODC degradation 2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IEA -- GO:0008073 ornithine decarboxylase inhibitor activity
TAS 7813017
About this table
Pathways & Interactions for OAZ1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for OAZ1 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for OAZ1 5/50 Interacting proteins for OAZ1 (ENSP00000314813 3 P54368 2 ) via UniProtKB, MINT, and/or STRING (see all 50
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006596 polyamine biosynthetic process
TAS 7813017
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Drugs & Compounds for OAZ1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for OAZ1 5 Novoseek chemical compound relationships for OAZ1 gene
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Transcripts for OAZ1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004152 Sigma-Aldrich siRNA for OAZ1 Sigma-Aldrich shRNA for OAZ1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004152
REFSEQ mRNAs for OAZ1 gene: NM_004152.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004152
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004152                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004152                                  untagged cDNA clone in CMV expression vector: NM_004152  
Additional cDNA sequence: AF090094.1 AK307221.1 BC007247.1 BC010063.1 BC013037.2 BC035151.1 BC042364.1 BC053360.1 BC055397.1 BC081537.1 BC093652.1 BC100291.1 BC112133.1 CR595080.1 CR601402.1 CR604371.1 CR608421.1 CR609439.1 CR618921.1 CR621194.1 CR622737.1 CR623800.1 D78361.1 D87914.1 U09202.1
24/47 DOTS entries (see all 47
): DT.100881247 DT.121414371 DT.91999328 DT.100039595 DT.121414664 DT.100881250 DT.454368 DT.121414420 DT.97774110 DT.97793139 DT.95338347 DT.101958942 DT.91999868 DT.95338331 DT.100881245 DT.100764895 DT.121414845 DT.100674595 DT.121414442 DT.100881236 DT.100881254 DT.95322781 DT.95338340 DT.100881253
24/2012 AceView cDNA sequences (see all 2012
):AI871787 BU163749 AJ573971 CA943848 BU782696 BE875106 BE894689 BM831566 BM916250 BU630596 BQ674110 BQ685222 BQ056074 BQ643421 AA351301 BM844789 BU682873 CA441977 AI819861 BQ880020 BQ614355 AI752892 BP871170 BU845874
highest scoring ESTs for OAZ1 :D78361 AA010461 AA024404 AA053130 AA079466 AA082459 AA088466 AA135093 AA182812 AA189133
Unigene Cluster for OAZ1: Ornithine decarboxylase antizyme 1 Hs.446427 [show with all ESTs ] Unigene Representative Sequence: BC035151 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for OAZ1 (see all 9
) ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d SP1 :     -   -           -   -                 SP2 :     -   -           -   -                 SP3 :     -   -           -   -                 SP4 :     -   -           -                   SP5 :     -   -   -   -       -   -                
About this scheme ECgene alternative splicing isoforms for OAZ1 1 Ensembl transcript including schematic representation : ENST00000322297
Expression for OAZ1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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OAZ1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for OAZ1 1 / 2 / 3
5 probe-sets matching OAZ1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTGTAATCGTSOURCE GeneReport for Unigene cluster: Hs.446427 Expression variation in blood from EXPOLDB for OAZ1
Orthologs for OAZ1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for OAZ1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for OAZ1 ENSEMBL Gene Tree for OAZ1 Paralogs for OAZ1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for OAZ1 gene OAZ2 2 OAZ3 2 Pseudogenes 1 related pseudogene
SNPs/Variants for OAZ1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for OAZ1 (up to first 250kb)
Disorders & Mutations for OAZ1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 601579 1 Novoseek disease relationship for OAZ1 gene
About this table Human Gene Mutation Database : OAZ1 Genetic Association Database: OAZ1 Human Genome Epidemiology Navigator: OAZ1 (2 documents)
Medical News for OAZ1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for OAZ1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/55 PubMed articles for OAZ1 gene (see all 55
): Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme. (PubMed id 7811704) 1, 2, 3, 4 Tewari D.S....Tewari M. (1994) Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization. (PubMed id 8954789) 1, 2, 3 Matsufuji S....Hayashi S. (1996) Molecular cloning of human antizyme cDNA. (PubMed id 9132164) 1, 3, 4 Yang D.... Onozaki K. (1996) [Variations within OLF1/EBF-associated zinc finger protein gene confer susceptibility to lupus nephritis in Chinese population] (PubMed id 16061000) 3, 6 Liang D....Qian J. (2005) The DNA sequence and biology of human chromosome 19. (PubMed id 15057824) 3, 4 Grimwood J.... Lucas S.M. (2004) Characterization of the human antizyme gene. (PubMed id 9426243) 3, 4 Hayashi T.... Hayashi S. (1997) A unified pathway for the degradation of ornithine decarboxylase in reticulocyte lysate requires interaction with the polyamine-induced protein, ornithine decarboxylase antizyme. (PubMed id 8001569) 1, 3 Mamroud-Kidron E....Kahana C. (1994) Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events. (PubMed id 17761941) 1, 3 Dumont J....Brousseau T. (2007) Structure and promoter activity of the gene encoding ornithine decarboxylase antizyme expressed exclusively in haploid germ cells in testis (OAZt/Oaz3). (PubMed id 12426106) 1, 3 Ike A....Nozaki M. (2002) Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. (PubMed id 17630775) 1, 3 Tsuji T....Hu G.F. (2007)
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Genome Databases showing OAZ1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing OAZ1
(According to HUGE )
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--
Specialized Databases showing OAZ1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
NIEHS-SNPs http://egp.gs.washington.edu/data/oaz1/
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-- Services for OAZ1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for OAZ1:
Recombinant Proteins (OAZ1 ) Antibodies (OAZ1 )
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