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OAZ1 Gene

protein-coding   GIFtS: 60

GC19P002220
ornithine decarboxylase antizyme 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: OAZ)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AZI 1, 2
MGC138338 1, 2
OAZ 2, 3
ODC-Az 3
Descriptions
antizyme 1 2
ornithine decarboxylase antizyme 1 2
External Ids
HGNC: 80951
Entrez Gene: 49462
UniProtKB: P543683
Ensembl: ENSG000001049047
Search outside databases for aliases for OAZ1 gene

Previous GC identifers: GC19P002332 GC19P002209

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for OAZ1:
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and
apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes
play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine
decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational
frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates
its degradation. [provided by RefSeq]

UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368
Function: Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits
cellular uptake of polyamines by inactivating the polyamine uptake transporter

Gene Wiki entry for OAZ1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OAZ1 gene  

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

OAZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P002220:     (about GC identifiers)

Start:
2,220,520 bp from pter
End:
2,224,487 bp from pter
Size:
3,968 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000019.8  NT_011255.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368 (See protein sequence)
Recommended Name: Ornithine decarboxylase antizyme  
Size: 228 amino acids; 25406 Da
Secondary accessions: O43382 Q14989 Q92595 Q9UPL9
Ribosomal frameshifting: 1 isoform:  P54368-1   (A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines)

REFSEQ proteins: NP_004143.1  

ENSEMBL proteins: 
ENSP00000314813 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (OAZ1)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005813 centrosome IDA18029348
GO:0005856 cytoskeleton IDA18029348
GO:0043231 intracellular membrane-bounded organelle IDA18029348
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Antibodies for OAZ1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for OAZ1
Browse R&D Systems for Antibodies
Antibodies from Abcam (OAZ1), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for OAZ1

Assays for OAZ1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR002993 ODC_AZ


   GeneDecks  OAZ1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P54368

ProtoNet protein and cluster: P54368

1 Blocks protein family: IPB002993 Ornithine decarboxylase antizyme

UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368
Similarity: Belongs to the ODC antizyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OAZ1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004152

              Applied Biosystems Silencer® siRNAs for OAZ1

              Sigma-Aldrich siRNA for OAZ1  
                     Sigma-Aldrich shRNA for OAZ1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004152
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004152
                                 untagged cDNA clone in CMV expression vector: NM_004152 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_004152

UniProtKB/Swiss-Prot: OAZ1_HUMAN, P54368
Function: Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits
cellular uptake of polyamines by inactivating the polyamine uptake transporter

Genatlas biochemistry entry for OAZ1:
ornithine decarboxylase antizyme 1,expressed in the liver,programming ribosomal
frameshifting,modulating the rate of ODC degradation

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IEA--
GO:0008073 ornithine decarboxylase inhibitor activity TAS7813017
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  OAZ1  (Your Favorite Gene powered by Ingenuity) 
 Polyamine Regulation in Colon Cancer

   GeneDecks  OAZ1 for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  OAZ1 


5/50 Interacting proteins for OAZ1 (ENSP000003148133 P543682) via UniProtKB, MINT, and/or STRING (see all 50 )
InteractantInteraction Details
GeneCardExternal ID(s)
ATXN1P542532MINT-2861439
ODC1ENSP000002341113STRING (score=.996)
OAZ3ENSP000003578203STRING (score=.966)
OAZ2ENSP000003162643STRING (score=.963)
AURKAIP1ENSP000003406563STRING (score=.96)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006596 polyamine biosynthetic process TAS7813017
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OAZ1
5 Novoseek chemical compound relationships for OAZ1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
ornithine 88.64 54 7811704 (2), 8001569 (2), 18384676 (2), 8878684 (2) (see all 28)
putrescine 66.90 1 11171097 (1)
spermidine 61.27 4 18974881 (1)
spermine 54.43 4 18974881 (1)
s-adenosylmethionine 45.47 4 18974881 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OAZ1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004152

              Sigma-Aldrich siRNA for OAZ1  
                     Sigma-Aldrich shRNA for OAZ1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_004152  

REFSEQ mRNAs for OAZ1 gene: 

NM_004152.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_004152  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004152
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004152
                                 untagged cDNA clone in CMV expression vector: NM_004152 

Additional cDNA sequence: 

AF090094.1 AK307221.1 BC007247.1 BC010063.1 BC013037.2 BC035151.1 BC042364.1 BC053360.1 
BC055397.1 BC081537.1 BC093652.1 BC100291.1 BC112133.1 CR595080.1 CR601402.1 CR604371.1 
CR608421.1 CR609439.1 CR618921.1 CR621194.1 CR622737.1 CR623800.1 D78361.1 D87914.1 
U09202.1 

24/47 DOTS entries (see all 47 ):

DT.100881247  DT.121414371  DT.91999328  DT.100039595  DT.121414664  DT.100881250  DT.454368  DT.121414420 
DT.97774110  DT.97793139  DT.95338347  DT.101958942  DT.91999868  DT.95338331  DT.100881245  DT.100764895 
DT.121414845  DT.100674595  DT.121414442  DT.100881236  DT.100881254  DT.95322781  DT.95338340  DT.100881253 

24/2012 AceView cDNA sequences (see all 2012 ):

AI871787 BU163749 AJ573971 CA943848 BU782696 BE875106 BE894689 BM831566 
BM916250 BU630596 BQ674110 BQ685222 BQ056074 BQ643421 AA351301 BM844789 
BU682873 CA441977 AI819861 BQ880020 BQ614355 AI752892 BP871170 BU845874 

highest scoring ESTs for OAZ1:

D78361 AA010461 AA024404 AA053130 AA079466 AA082459 AA088466 AA135093 AA182812 AA189133 

Unigene Cluster for OAZ1:

Ornithine decarboxylase antizyme 1
Hs.446427  [show with all ESTs]
Unigene Representative Sequence: BC035151


GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for OAZ1 (see all 9 )

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d
SP1:              -     -                             -     -                                             
SP2:              -     -                             -     -                                             
SP3:              -     -                             -     -                                             
SP4:              -     -                             -                                                   
SP5:              -     -     -     -                 -     -                                             

About this scheme

ECgene alternative splicing isoforms for OAZ1

1 Ensembl transcript including schematic representation:
ENST00000322297  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OAZ1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OAZ1

1 / 2 / 3

5 probe-sets matching OAZ1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

1315_at2, 3 U95-A 2 1.00 0.88 1.00 1.00 D78361 1.00 1.00 1.00 1

215952_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF090094 0.20 0.50 0.38 1

200077_s_at2, 3 U133-B 1 1.00 1.00 -- -- D87914 0.80 1.00 0.91 1

215952_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

200077_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TTGTAATCGT

SOURCE GeneReport for Unigene cluster: Hs.446427

Expression variation in blood from EXPOLDB for OAZ1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OAZ1 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OAZ11   -- ornithine decarboxylase antizyme 1 92.87(n)
92.45(a)
476749  XM_533955.2  XP_533955.2 
cow
(Bos taurus)
OAZ11   -- ornithine decarboxylase antizyme 1 95.1(n)
91.18(a)
506973  NM_001025323.1  NP_001020494.1 
rat
(Rattus norvegicus)
Oaz11   -- ornithine decarboxylase antizyme 1 85.61(n)
84.14(a)
25502  NM_139081.1  NP_620781.1 
mouse
(Mus musculus)
Oaz11, 5 10 (43.00 cM)5
ornithine decarboxylase antizyme 11, 5 85.32(n)1
83.7(a)1
182451  NM_008753.41  NP_032779.11 
 AA2613495  AI8389435  (see all 31)
chicken
(Gallus gallus)
OAZ11   -- ornithine decarboxylase antizyme 1 82.72(n)
85.65(a)
395746  NM_204916.1  NP_990247.1 
About this table        Species with no ortholog for OAZ1

ENSEMBL Gene Tree for OAZ1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OAZ1 gene
OAZ22  OAZ32  

Pseudogenes
1 related pseudogene


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/20 NCBI SNPs in OAZ1 are shown (see all 20 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 66)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs131401,2
A,C,F2224146(+) GCCACC/TCCTTG 1 -- ut31 ese32Minor allele frequency- T:0.01MN NS 356
--
rs46671,2
A,C,F2220692(+) CAGCCG/TCACCA 1 R/L mis12Minor allele frequency- T:0.00MN NS 362
rs22307491,2
C,F2222395(+) GGTCTC/TCCTCC 1 S/F mis1 ese32Minor allele frequency- T:0.01MN NS 222
rs283846731,2
C,F2222386(+) CAGTTC/TCAGGG 1 S/F mis1 ese37Minor allele frequency- T:0.02NS 834
rs283846881,2
C,F2224444(+) TTAATC/TCCCTC 1 -- ut31 ese37Minor allele frequency- T:0.02NS 818
rs283597621,2
C,F2220728(+) CGGCGG/ACAGCA 1 D/G mis1 ese37Minor allele frequency- A:0.02NS 840
rs10572301,2
H2224093(+) CGGGAG/AAGGAG 1 K/R mis1 ese3 trp35Minor allele frequency- A:0.00MN EU EA WA 590
rs142961,2
H2222500(+) GGGATC/TACAAT 1 S/L mis14Minor allele frequency- T:0.00EU EA WA 406
rs10571501,2
H2224079(+) CGAGAG/AAGAGT 1 E/E mis15Minor allele frequency- A:0.00MN EU EA WA 586
rs283846861,2
F2224150(+) CCCCTT/CGTCAG 1 -- ut31 ese31Minor allele frequency- C:0.01NS 172
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HapMap Linkage Disequilibrium images for OAZ1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601579

1 Novoseek disease relationship for OAZ1 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 3.71 7 12888889 (3), 9692545 (2), 16847581 (1), 15009201 (1)
About this table

Human Gene Mutation Database: OAZ1
Genetic Association Database: OAZ1
Human Genome Epidemiology Navigator: OAZ1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/55 PubMed articles for OAZ1 gene (see all 55 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4946 HGNC: 8095 AceView: OAZ1 Ensembl:ENSG00000104904 euGenes: HUgn4946
ECgene: OAZ1 H-InvDB: OAZ1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
NIEHS-SNPshttp://egp.gs.washington.edu/data/oaz1/
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OAZ1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for OAZ1 Antibodies for OAZ1
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OAZ1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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