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OAT Gene

protein-coding GIFtS: 63

GC10M126075

ornithine aminotransferase (gyrate atrophy)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp781A11155 ^²
EC 2.6.1.13 ^³
HOGA ^¹, ²
OTTHUMP00000020690 ^²

Descriptions
Ornithine--oxo-acid aminotransferase ^³
ornithine aminotransferase ^²
ornithine aminotransferase (gyrate atrophy) ^²

External Ids
HGNC: 8091¹
Entrez Gene: 4942²
UniProtKB: P04181³
Ensembl: ENSG00000065154⁷

Search outside databases for aliases for OAT gene

Previous GC identifers: GC10M125055 GC10M125289 GC10M126126 GC10M125660

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OAT:

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme is the

pathway that converts arginine and ornithine into the major excitatory and inhibitory

neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause

the autosomal recessive eye disease Gyrate Atrophy. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OAT gene

Entrez Gene cytogenetic band: 10q26 Ensembl cytogenetic band: 10q26.13 HGNC cytogenetic band: 10q26

OAT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M126075: (about GC identifiers)

Start:	126,075,862 bp from pter
End:	126,097,450 bp from pter
Size:	21,589 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_035040.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OAT_HUMAN, P04181 (See protein sequence)

Recommended Name: Ornithine aminotransferase, mitochondrial precursor

Size: 439 amino acids; 48535 Da

Cofactor: Pyridoxal phosphate

Subunit: Homotetramer

Subcellular location: Mitochondrion matrix

PDB structures from and Proteopedia :

1GBN (3D)

1OAT (3D)

2BYJ (3D)

2BYL (3D)

2CAN (3D)

2OAT (3D)

Secondary accessions: Q16068 Q16069 Q6IAV9 Q9UD03

REFSEQ proteins: NP_000265.1

ENSEMBL proteins:

ENSP00000357838 ENSP00000385802

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ornithine aminotransferase)
	Human Recombinant Proteins from Abnova (OAT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	TAS	2793865
GO:0005759	mitochondrial matrix	NAS	3456579

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Antibodies for OAT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for OAT
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ornithine aminotransferase), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OAT

Assays for OAT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P04181

ProtoNet protein and cluster: P04181

1 Blocks protein family: IPB005814 Aminotransferase class-III

UniProtKB/Swiss-Prot: OAT_HUMAN, P04181

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OAT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000274

Applied Biosystems Silencer® siRNAs for OAT

Sigma-Aldrich siRNA and siRNA Panels for OAT

Sigma-Aldrich shRNA for OAT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OAT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000274
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000274
untagged cDNA clones in CMV expression vector (see all 2): NM_000274

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000274

UniProtKB/Swiss-Prot: OAT_HUMAN, P04181

Catalytic activity: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid

Enzyme Number (IUBMB): EC 2.6.1.13

Genatlas biochemistry entry for OAT:

ornithine aminotransferase,proline and ornithine metabolic pathway,mitochondrial matrix

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Oat):

behavior/neurological	homeostasis/metabolism	lethality-prenatal/perinatal	nervous system	pigmentation
renal/urinary system	vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004587	ornithine-oxo-acid transaminase activity	TAS	3456579
GO:0005515	protein binding	IPI	17353931
GO:0016740	transferase activity	IEA	--
GO:0030170	pyridoxal phosphate binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for OAT (Your Favorite Gene powered by Ingenuity)

Urea Cycle and Metabolism of Amino Groups
Arginine and Proline Metabolism

GeneDecks OAT for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: OAT_HUMAN, P04181

Pathway: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from

L-ornithine: step 1/1

5/29 Interacting proteins for OAT (ENSP00000357838³ P04181^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF6	P56537¹	EBI-721662, EBI-372243
UBQLN4	Q9NRR5²	MINT-2861399
ARG1	ENSP00000349446³	STRING (score=.994)
OTC	ENSP00000039007³	STRING (score=.994)
ARG2	ENSP00000261783³	STRING (score=.992)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007601	visual perception	TAS	2793865

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OAT
10/11 Novoseek chemical compound relationships for OAT gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
5-fluoromethylornithine	95.54	16	9538890 (2), 8234188 (2), 7707692 (1), 9878407 (1) (see all 7)
ornithine	93.11	227	18280134 (5), 18680626 (5), 9309222 (4), 11271933 (4) (see all 91)
gamma-glutamyl semialdehyde	88.99	3	9514741 (1), 9878407 (1)
l-canaline	86.80	6	9309222 (3), 11465067 (1), 11222476 (1)
delta(1)pyrroline-5-carboxylate	74.24	6	9514741 (1), 18506409 (1)
carbamoyl phosphate	54.17	3	19000307 (1), 7978367 (1)
proline	46.74	8	18506409 (2), 18330497 (1), 11222476 (1), 18280134 (1)
putrescine	45.83	3	18280134 (1), 7609280 (1), 11222476 (1)
urea	42.36	3	18806117 (1), 8272027 (1), 7485563 (1)
ecori	26.66	1	1618792 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OAT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000274

Sigma-Aldrich siRNA and siRNA Panels for OAT

Sigma-Aldrich shRNA for OAT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000274

REFSEQ mRNAs for OAT gene:

NM_000274.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000274

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000274
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000274
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_000274

Additional cDNA sequence:

AB208817.1 AK296032.1 AK312561.1 AK315947.1 BC000964.2 BC016928.1 CR457045.1 CR604740.1

CR605069.1 CR749808.1 M12267.1 M14963.1 M23204.1 Y07511.1

22 DOTS entries:

DT.419122 DT.92455333 DT.100838550 DT.92064991 DT.100883494 DT.97860298 DT.121242267 DT.92455334

DT.100883502 DT.100883508 DT.95167699 DT.121242322 DT.91977575 DT.100883497 DT.121242257 DT.121242327

DT.121242329 DT.95167701 DT.95167702 DT.100712175 DT.121242330 DT.95337749

24/518 AceView cDNA sequences (see all 518 ):

AI755132 BP346318 BQ718413 BQ955175 AL549701 F09537 BE794286 BU507900

BP350822 BQ771983 CA945101 BQ962634 CD679109 BU169718 BF514733 CA412690

R37863 CN481668 CD678683 CF131713 AL560219 BM552611 NM_000274 CR604740

highest scoring ESTs for OAT:

M12267 AA331687 AA336312 AL521003 AL559079 AL598933 AL697697 AU118734 AU133128 AU138196

Unigene Cluster for OAT:

Ornithine aminotransferase (gyrate atrophy)

Hs.523332 [show with all ESTs]

Unigene Representative Sequence: AB208817

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for OAT (see all 13 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	·
SP1:					-		-		-		-		-		-		-										-		-		-								-
SP2:																											-		-		-								-
SP3:																															-								-
SP4:																									-		-		-		-
SP5:

ExUns:	13c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for OAT

2 Ensembl transcripts including schematic representations:

ENST00000368845 ENST00000405216

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OAT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OAT

¹ / ² / ³

3 probe-sets matching OAT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36636_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M12267	1.00	1.00	1.00	1
201599_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000274	0.60	1.00	0.82	1
201599_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTACTTCCT

SOURCE GeneReport for Unigene cluster: Hs.523332
Expression variation in blood from EXPOLDB for OAT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OAT gene from 5/26 species (see all 26 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OAT¹	--	ornithine aminotransferase (gyrate atrophy)	88(n) 92.71(a)	477858 XM_535050.2 XP_535050.2
chimpanzee (Pan troglodytes)	OAT¹	--	ornithine aminotransferase (gyrate atrophy)	99.85(n) 100(a)	450803 XM_508094.2 XP_508094.2
cow (Bos taurus)	OAT¹	--	ornithine aminotransferase (gyrate atrophy)	89.6(n) 93.17(a)	505323 NM_001034240.1 NP_001029412.1
rat (Rattus norvegicus)	Oat¹	--	ornithine aminotransferase (gyrate atrophy)	83.9(n) 90.66(a)	64313 NM_022521.2 NP_071966.1
mouse (Mus musculus)	Oat^{1, 5}	7 (63.00 cM)⁵	ornithine aminotransferase^{1, 5}	84.51(n)¹ 90.89(a)¹	18242¹ NM_016978.2¹ NP_058674.1¹ AI194874⁵ AK128914⁵ (see all 19)

About this table Species with no ortholog for OAT

ENSEMBL Gene Tree for OAT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OAT gene

ABAT²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/208 NCBI SNPs in OAT are shown (see all 208 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 69)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs2459216^1,2	A,C,F,H	126076316(+)	`GTTACG/ATTACA`	1	--	ut3¹ ese³		11		EU EA WA NA	974
	rs2282694^1,2	A,C,F,H	126097962(-)	`GTGGAC/TTCAGA`	1	--	ng3¹		5		EA EU WA	1146
	rs8182^1,2	A,F,H	126075966(-)	`ATTAGT/CGTTTA`	1	--	ut3¹		9		NS EU EA WA	516
--	rs11553548^1,2	H	126076605(-)	`CCAAGC/TCAACC`	1	P/S	mis¹		4		EU EA WA	406
--	rs11244823^1,2	A	126099359(+)	`ATTCCA/GCCCAA`	1	--	ng3¹		0	--	--	--	--
--	rs17173738^1,2	F	126097935(-)	`GCGGCG/CCATCA`	1	--	ng3¹		2		MN EA	356
--	rs2459218^1,2	C	126099358(+)	`TATTCC/TGCCCA`	1	--	ng3¹		0	--	--	--	--
	rs2807074^1,2	F	126098351(+)	`CCCAGC/ATGGAA`	1	--	ng3¹		2		MN EA	356
--	rs11553551^1,2	H	126087440(-)	`TCACCC/GCAAGA`	1	P/R	mis¹ ese³		4		EU EA WA	370
--	rs11553554^1,2	H	126090579(-)	`GTATGG/ATGCAC`	1	D/G	mis¹ ese³		4		EU EA WA	406

About this table

HapMap Linkage Disequilibrium images for OAT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 258870

UniProtKB/Swiss-Prot: OAT_HUMAN, P04181

Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and

retina (HOGA) [MIM:258870]. HOGA is a slowly progressive blinding autosomal recessive disorder

10/12 Novoseek disease relationships for OAT gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gyrate atrophy	98.54	65	1635292 (5), 2220818 (2), 9538890 (2), 1301936 (2) (see all 39)
ornithine aminotransferase deficiency	96.85	4	16151897 (1), 16601905 (1), 1682785 (1), 1789102 (1)
hyperammonemia	70.79	7	16151897 (2), 9286430 (1), 18806117 (1), 7707692 (1) (see all 5)
blindness	44.58	7	2220818 (1), 9514741 (1), 9309222 (1), 9414260 (1) (see all 6)
eye diseases	43.05	2	2220818 (1), 1487247 (1)
retinal degeneration	40.19	1	16601905 (1)
metabolic disorder	36.30	2	15750329 (1)
hepatomegaly	21.95	1	15563600 (1)
genetic disorder	19.41	2	16906410 (1), 9514741 (1)
cell damage	16.61	1	16597690 (1)

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Genatlas disease: OAT

hyperornithinemia,with gyrate atrophy of choroid and retina

Human Gene Mutation Database: OAT
Genetic Association Database: OAT

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/119 PubMed articles for OAT gene (see all 119 ):

Molecular pathology of gyrate atrophy of the choroid and retina due to ornithine aminotransferase deficiency. (PubMed id 1682785)^{1, 2, 3, 4} Ramesh V.... Shih V.E. (1991)
A single amino acid substitution within the mature sequence of ornithine aminotransferase obstructs mitochondrial entry of the precursor. (PubMed id 7668253)^{1, 3, 4} Kobayashi T.... Matsuzawa T. (1995)
Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition. (PubMed id 9309222)^{1, 3, 4} Shah S.A.... Brunger A.T. (1997)
Crystal structure of human recombinant ornithine aminotransferase. (PubMed id 9514741)^{1, 3, 4} Shen B.W.... Schirmer T. (1998)
Analysis of the human ornithine aminotransferase gene family. (PubMed id 2373169)^{1, 3, 4} Zintz C.B. and Inana G. (1990)
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine. (PubMed id 9878407)^{1, 3, 4} Storici P.... Jansonius J.N. (1999)
Pyridoxine-responsive gyrate atrophy of the choroid and retina: clinical and biochemical correlates of the mutation A226V. (PubMed id 7887415)^{1, 3, 4} Michaud J.... Mitchell G.A. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Strand-separating conformational polymorphism analysis: efficacy of detection of point mutations in the human ornithine delta- aminotransferase gene. (PubMed id 1612597)^{3, 4} Michaud J....Mitchell G. (1992)
Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences. (PubMed id 1737786)^{3, 4} Brody L.C.... Valle D. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4942	HGNC: 8091	AceView: OAT	Ensembl:ENSG00000065154	euGenes: HUgn4942
ECgene: OAT	H-InvDB: OAT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=OAT

Licensable Technologies for OAT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OAT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OAT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OAT		Antibodies for OAT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OAT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OAT)
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	Recombinant Proteins (ornithine aminotransferase)
	Antibodies (ornithine aminotransferase)

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Search Tocris compounds for OAT

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OAT

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
OAT Gene at Home site.
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OAT Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for OAT

Summaries
for OAT

Genomic Location
for OAT

Proteins
for OAT

Protein Domains/
Families
for OAT

Gene Function
for OAT

Pathways & Interactions
for OAT

Drugs & Compounds
for OAT

Transcripts
for OAT

Expression
for OAT

Orthologs
for OAT

Paralogs
for OAT

SNPs/Variants
for OAT

Disorders & Mutations
for OAT

Medical News
for OAT

Publications
for OAT

Search for OAT

Genome Databases showing OAT

Other Databases showing OAT

Specialized Databases showing OAT

Licensable Technologies
for OAT

Services
for OAT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OAT Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor OAT

Summariesfor OAT

Genomic Locationfor OAT

Proteinsfor OAT

Protein Domains/Familiesfor OAT

Gene Functionfor OAT

Pathways & Interactionsfor OAT

Drugs & Compoundsfor OAT

Transcriptsfor OAT

Expression for OAT

Orthologsfor OAT

Paralogsfor OAT

SNPs/Variantsfor OAT

Disorders & Mutationsfor OAT

Medical Newsfor OAT

Publicationsfor OAT

Search for OAT

Genome Databases showing OAT

Other Databases showing OAT

Specialized Databases showing OAT

Licensable Technologiesfor OAT

Servicesfor OAT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OAT

Summaries
for OAT

Genomic Location
for OAT

Proteins
for OAT

Protein Domains/
Families
for OAT

Gene Function
for OAT

Pathways & Interactions
for OAT

Drugs & Compounds
for OAT

Transcripts
for OAT

Expression
for OAT

Orthologs
for OAT

Paralogs
for OAT

SNPs/Variants
for OAT

Disorders & Mutations
for OAT

Medical News
for OAT

Publications
for OAT

Licensable Technologies
for OAT

Services
for OAT