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Aliases & Descriptions for OASL
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases TRIP-14 3 TRIP14 1 , 2 , 3 , 5 p59OASL 1 , 2 , 3
Descriptions 2'-5'-oligoadenylate synthetase-like 2 Thyroid receptor-interacting protein 14 3 p59 OASL 3
Search outside databases for aliases for OASL genePrevious GC identifers: GC12M120319 GC12M121055 GC12M121240 GC12M119870
Summaries for OASL (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646 Function : Does not have 2'-5'-OAS activity, but binds double-stranded RNA and DNA
Gene Wiki entry for OASL
Genomic Location for OASL
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the OASL gene Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.2 OASL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M119920:
(about GC identifiers )
Start:
119,942,478 bp from pter
End:
119,961,342 bp from pter
Size:
18,865 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000012.10 NT_009775.16 Proteins for OASL
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646 (See
protein sequence )Recommended Name: 59 kDa 2'-5'-oligoadenylate synthetase-like protein Size : 514 amino acids; 59226 Da
Subunit : Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14does not require the presence of thyroid hormone for its interaction. Binds MBD1
Caution : This may not be the true ortholog of mouse OASL
Sequence caution : Sequence=AAC41733.1; Type=Frameshift; Positions=386;
PDB structures from and Proteopedia : 1WH3 (3D)
 
Secondary accessions : O75686 Q17R95 Q9Y6K6 Q9Y6K7Alternative splicing : 2 isoforms : Q15646-1 Q15646-2
REFSEQ proteins (2 alternative transcripts):
NP_003724.1 NP_937856.1 ENSEMBL proteins: ENSP00000257570 ENSP00000341125 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for OASL: Assays for OASL:
Protein
Domains/ Families for OASL(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q15646 ProtoNet protein and cluster: Q15646
2 Blocks protein families : IPB000626 Ubiquitin domain IPB006117 2-5-oligoadenylate synthetase UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646 Similarity : Belongs to the 2-5A synthetase familySimilarity : Contains 2 ubiquitin-like domains
Gene Function for OASL
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_003733 Applied Biosystems Silencer ® siRNAs for OASL Sigma-Aldrich siRNA and siRNA Panels for OASL Sigma-Aldrich shRNA for OASL Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_003733                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_003733                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_003733  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003733 UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646 Function : Does not have 2'-5'-OAS activity, but binds double-stranded RNA and DNAInduction : By interferons
Genatlas biochemistry entry for OASL :2',5' oligoadenylate synthetase-like,interferon induced,cytoplasmic and nucleolar 5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for OASL
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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4 Interacting proteins for OASL (ENSP00000257570 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006464 protein modification process
IEA -- GO:0006955 immune response
IEA -- GO:0008150 biological_process
ND --
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Drugs & Compounds for OASL (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for OASL
Transcripts for OASL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_003733 Sigma-Aldrich siRNA and siRNA Panels for OASL Sigma-Aldrich shRNA for OASL Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_003733 NM_198213
REFSEQ mRNAs for OASL gene (2 alternative transcripts): NM_003733.2 NM_198213.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003733 NM_198213
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_003733                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_003733                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_003733  
Additional cDNA sequence: AJ225089.1 AK023956.1 AK314419.1 BC117408.1 BC117410.1 CR609351.1
5 DOTS entries : DT.307381 DT.100748407 DT.40228111 DT.95159820 DT.86847026
24/75 AceView cDNA sequences (see all 75
):AW069118 NM_198213 BP381869 CR609351 NM_003733 AL711263 CB125965 BU542269 BM909951 BM769452 BI822276 BP378298 AW088013 AV727701 CA307835 BQ947576 AK023956 AJ225089 BG745007 BM918192 CA431656 AA366958 BG744279 AA115392
highest scoring ESTs for OASL :AJ225089 AK023956 AL711263 AU142043 BE784824 BE870544 BF175944 BF685469 BG339739 BG744279
Unigene Cluster for OASL: 2'-5'-oligoadenylate synthetase-like Hs.118633 [show with all ESTs ] Unigene Representative Sequence: AK023956 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for OASL ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b SP1 :                     SP2 :           -           SP3 :       -     -          
About this scheme ECgene alternative splicing isoforms for OASL 2 Ensembl transcripts including schematic representations : ENST00000257570
ENST00000339275
Expression for OASL
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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OASL expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for OASL 1 / 2 / 3
6 probe-sets matching OASL gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGGCAAAGCCSOURCE GeneReport for Unigene cluster: Hs.118633 Expression variation in blood from EXPOLDB for OASL
UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646 Tissue specificity : Expressed in most tissues, with the highest levels in primary blood Leukocytesand other hematopoietic system tissues, colon, stomach and to some extent in testis
Orthologs for OASL
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for OASL gene from 5/6 species (see all 6
)
About this table Species with no ortholog for OASL ENSEMBL Gene Tree for OASL Paralogs for OASL (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for OASL gene OAS2 2 OAS1 2 OAS3 2
SNPs/Variants for OASL (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for OASL (up to first 250kb)
Disorders & Mutations for OASL
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 603281 Genetic Association Database: OASL Human Genome Epidemiology Navigator: OASL (2 documents)
Medical News for OASL (Possibly Related Articles in
Doctor's Guide )
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--
Publications for OASL (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/16 PubMed articles for OASL gene (see all 16
): Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. (PubMed id 14728690) 1, 3, 4 Andersen J.B.... Justesen J. (2004) p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. (PubMed id 9722630) 1, 3, 4 Hartmann R.... Justesen J. (1998) The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. (PubMed id 10087211) 1, 2, 3 Hovnanian A....Hovanessian A.G. (1999) The finished DNA sequence of human chromosome 12. (PubMed id 16541075) 3, 4 Scherer S.E.... Gibbs R.A. (2006) Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. (PubMed id 16235172) 3, 6 Yakub I....Tweardy D.J. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Molecular cloning and characterization of two related and interferon- induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase. (PubMed id 9826176) 3, 4 Rebouillat D.... Hovanessian A.G. (1998) Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974) 3, 4 Lee J.W....Moore D.D. (1995) The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain. (PubMed id 18931074) 3 Marques J....Hartmann R. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008)
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Genome Databases showing OASL
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing OASL
(According to HUGE )
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Specialized Databases showing OASL (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for OASL (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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