V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

OASL Gene

protein-coding   GIFtS: 57

GC12M119920
2'-5'-oligoadenylate synthetase-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
TRIP-14 3
TRIP14 1, 2, 3, 5
p59OASL 1, 2, 3
Descriptions
2'-5'-oligoadenylate synthetase-like 2
Thyroid receptor-interacting protein 14 3
p59 OASL 3
External Ids
HGNC: 80901
Entrez Gene: 86382
UniProtKB: Q156463
Ensembl: ENSG000001351147
Search outside databases for aliases for OASL gene

Previous GC identifers: GC12M120319 GC12M121055 GC12M121240 GC12M119870

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646
Function: Does not have 2'-5'-OAS activity, but binds double-stranded RNA and DNA

Gene Wiki entry for OASL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OASL gene  

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.2

OASL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M119920:     (about GC identifiers)

Start:
119,942,478 bp from pter
End:
119,961,342 bp from pter
Size:
18,865 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_009775.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646 (See protein sequence)
Recommended Name: 59 kDa 2'-5'-oligoadenylate synthetase-like protein  
Size: 514 amino acids; 59226 Da
Subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14
does not require the presence of thyroid hormone for its interaction. Binds MBD1
Caution: This may not be the true ortholog of mouse OASL
Sequence caution: Sequence=AAC41733.1; Type=Frameshift; Positions=386;
PDB structures from and Proteopedia :
1WH3 (3D)    
Secondary accessions: O75686 Q17R95 Q9Y6K6 Q9Y6K7
Alternative splicing: 2 isoforms:  Q15646-1   Q15646-2   

REFSEQ proteins (2 alternative transcripts): 
NP_003724.1  NP_937856.1  


ENSEMBL proteins: 
ENSP00000257570 ENSP00000341125 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (OASL)
Human Recombinant Proteins from Abnova (OASL)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IDA18029348
GO:0005730 nucleolus TAS9826176
GO:0005737 cytoplasm TAS9826176
About this table

Antibodies for OASL: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for OASL
Browse R&D Systems for Antibodies
Antibodies from Abcam (OASL), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (OASL)
Search Novus for antibodies for OASL

Assays for OASL: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5 InterPro domains/families:
 IPR006116 2-5-oligoadenylate_synth_UB
 IPR018952 2-5-oligoAdlate_synth_1_dom2/C
 IPR006117 2-5-oligoadenylate_synth_CS
 IPR000626 Ubiquitin
 IPR019955 Ubiquitin_supergroup


   GeneDecks  OASL for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q15646

ProtoNet protein and cluster: Q15646

2 Blocks protein families:
IPB000626 Ubiquitin domain
IPB006117 2-5-oligoadenylate synthetase


UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646
Similarity: Belongs to the 2-5A synthetase family
Similarity: Contains 2 ubiquitin-like domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OASL)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OASL)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003733

              Applied Biosystems Silencer® siRNAs for OASL

              Sigma-Aldrich siRNA and siRNA Panels for OASL  
                     Sigma-Aldrich shRNA for OASL  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003733
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003733
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003733 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_003733

UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646
Function: Does not have 2'-5'-OAS activity, but binds double-stranded RNA and DNA
Induction: By interferons

Genatlas biochemistry entry for OASL:
2',5' oligoadenylate synthetase-like,interferon induced,cytoplasmic and nucleolar

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding TAS9826176
GO:0003725 double-stranded RNA binding TAS9826176
GO:0005524 ATP binding IEA--
GO:0016740 transferase activity IEA--
GO:0046966 thyroid hormone receptor binding TAS7776974
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



4 Interacting proteins for OASL (ENSP000002575703) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
MX1ENSP000002883833STRING (score=.704)
IFNGENSP000002291353STRING (score=.7)
--ENSP000003695523STRING (score=.787)
--ENSP000003025233STRING (score=.73)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006464 protein modification process IEA--
GO:0006955 immune response IEA--
GO:0008150 biological_process ND--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OASL

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OASL)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OASL)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003733

              Sigma-Aldrich siRNA and siRNA Panels for OASL  
                     Sigma-Aldrich shRNA for OASL  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_003733  NM_198213  

REFSEQ mRNAs for OASL gene (2 alternative transcripts): 

NM_003733.2   NM_198213.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_003733  NM_198213  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003733
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003733
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003733 

Additional cDNA sequence: 

AJ225089.1 AK023956.1 AK314419.1 BC117408.1 BC117410.1 CR609351.1 

5 DOTS entries:

DT.307381  DT.100748407  DT.40228111  DT.95159820  DT.86847026 

24/75 AceView cDNA sequences (see all 75 ):

AW069118 NM_198213 BP381869 CR609351 NM_003733 AL711263 CB125965 BU542269 
BM909951 BM769452 BI822276 BP378298 AW088013 AV727701 CA307835 BQ947576 
AK023956 AJ225089 BG745007 BM918192 CA431656 AA366958 BG744279 AA115392 

highest scoring ESTs for OASL:

AJ225089 AK023956 AL711263 AU142043 BE784824 BE870544 BF175944 BF685469 BG339739 BG744279 

Unigene Cluster for OASL:

2'-5'-oligoadenylate synthetase-like
Hs.118633  [show with all ESTs]
Unigene Representative Sequence: AK023956


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for OASL

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1:                                                            
SP2:                                -                           
SP3:                    -           -                           

About this scheme

ECgene alternative splicing isoforms for OASL

2 Ensembl transcripts including schematic representations:
ENST00000257570  ENST00000339275  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OASL expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OASL

1 / 2 / 3

6 probe-sets matching OASL gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

34491_at2, 3 U95-A 1 1.00 1.00 0.86 1.17 AJ225089 1.00 1.00 1.00 1

269_at2, 3 U95-A 1 1.00 1.00 0.88 0.84 L40387 0.20 1.00 0.72 1

210797_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF063612 0.60 1.00 0.82 1

205660_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003733 0.60 1.00 0.82 1

210797_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

205660_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGGCAAAGCC

SOURCE GeneReport for Unigene cluster: Hs.118633

Expression variation in blood from EXPOLDB for OASL

UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646
Tissue specificity: Expressed in most tissues, with the highest levels in primary blood Leukocytes
and other hematopoietic system tissues, colon, stomach and to some extent in testis

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OASL gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OASL1   -- 2'-5'-oligoadenylate synthetase-like 80.98(n)
74.55(a)
477518  XM_534713.2  XP_534713.2 
chimpanzee
(Pan troglodytes)
OASL1   -- 2'-5'-oligoadenylate synthetase-like 99.35(n)
98.25(a)
452317  XM_001163582.1  XP_001163582.1 
cow
(Bos taurus)
OASL1   -- 2'-5'-oligoadenylate synthetase-like 75.76(n)
62.06(a)
408021  XM_611954.3  XP_611954.3 
rat
(Rattus norvegicus)
Oasl1   -- 2'-5'-oligoadenylate synthetase-like 78.26(n)
73.96(a)
304545  NM_001009681.1  NP_001009681.1 
mouse
(Mus musculus)
Oasl11, 5 55
2'-5' oligoadenylate synthetase-like 11, 5 77.52(n)1
70.98(a)1
2316551  NM_145209.31  NP_660210.11 
 AA1850475  AB0675335  (see all 15)
About this table        Species with no ortholog for OASL

ENSEMBL Gene Tree for OASL
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OASL gene
OAS22  OAS12  OAS32  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/126 NCBI SNPs in OASL are shown (see all 126 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 44)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs100830421,2
A,C,F,H119961647(+) CTGGAG/TCCCAA 2 -- ng314Minor allele frequency- T:0.03EU EA WA 420
--
rs22596931,2
A,C,F,H119942378(-) cacacC/Tgctac 2 -- ng518Minor allele frequency- T:0.50EU EA WA NA NS 985
rs45566281,2
A,C,F,H119962295(+) AAGACC/TGGGGA 2 -- ng314Minor allele frequency- T:0.21EU EA WA 420
--
rs22596901,2
A,C,F119942297(-) AAAAAA/CAGGAT 2 -- ng515Minor allele frequency- N:0.01EA NA NS 643
rs128192101,2
C,F,H119942783(+) TTCTTC/TGAGAG 2 S/S syn1 ut31 ese3 trp310Minor allele frequency- T:0.36EU EA WA NS NA 1279
--
rs108498331,2
A,F,H119962413(+) TGGACG/ACCTGC 2 -- ng314Minor allele frequency- A:0.15EU EA WA 418
--
rs22596971,2
A,C,F119942521(-) tatcaT/Caggga 2 -- ut31 ese33Minor allele frequency- C:0.23NA 140
--
rs19848411,2
A,C119962023(-) gctcaC/Tgctgt 2 -- ng310--------
--
rs100830441,2
A,C119961764(+) gccggA/Gtcttg 2 -- ng310--------
rs352499201,2
C,F119946201(+) TGGGGT/ATCTCC 2 I/N mis1 ut311Minor allele frequency- A:0.07NA 72
About this table

HapMap Linkage Disequilibrium images for OASL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603281

Genetic Association Database: OASL
Human Genome Epidemiology Navigator: OASL (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/16 PubMed articles for OASL gene (see all 16 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8638 HGNC: 8090 AceView: OASL Ensembl:ENSG00000135114 euGenes: HUgn8638
ECgene: OASL H-InvDB: OASL
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OASL:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OASL-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OASL Antibodies for OASL
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OASL Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (OASL)
 Antibodies (OASL)
 Chimera RNAi (OASL)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(OASL)
 Antibodies (OASL)
 Search OriGene for OASL
 Search Tocris compounds for OASL




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for OASL

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
OASL Gene at Home site.
Version 2.41.1
server5.xennexinc.com