OASL Gene
protein-coding GIFtS: 59
GCID: GC12M121459
|
|
2'-5'-oligoadenylate synthetase-like
| |
Aliases
for OASL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 2'-5'-Oligoadenylate Synthetase-Like1 2 | | TRIP-142 3 | | TRIP141 2 3 5 | | P59 OASL2 3 | | P59OASL1 | | TR-Interacting Protein 142 3 | | Thyroid Receptor-Interacting Protein 142 3 | | 2'-5'-Oligoadenylate Synthase-Like Protein2 | | 2'-5'-OAS-RP2 3 | | 59 KDa 2'-5'-Oligoadenylate Synthetase-Like Protein2 | | 2'-5'-OAS-Related Protein2 3 | | OASLd2 | | 59 KDa 2'-5'-Oligoadenylate Synthase-Like Protein2 3 | | P59-OASL1 |
Export aliases for OASL gene to outside databasesPrevious GC identifers: GC12M120319 GC12M121055 GC12M121240 GC12M119870 GC12M119920 GC12M118466 |
Summaries
for OASL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646Function: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity againstencephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent ofRNase L
Gene Wiki entry for OASL
|
Genomic Views
for OASL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OASL gene promoter:
Elk-1 RFX1 STAT1beta Olf-1 STAT1alpha PPAR-gamma1 IRF-2 NRF-2 Ik-2 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OASL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OASL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.2OASL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M121459: view genomic region
(about GC identifiers)
Start:
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121,458,095 bp from pter |
End:
|
121,477,045 bp from pter |
Size:
|
18,951 bases |
Orientation:
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minus strand |
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Proteins
for OASL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646 (See
protein sequence)Recommended Name: 2'-5'-oligoadenylate synthase-like protein Size: 514 amino acids; 59226 Da
Subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not requirethe presence of thyroid hormone for its interaction. Binds MBD1
Subcellular location: Isoform p56: Nucleus, nucleolus. Cytoplasm
Subcellular location: Isoform p30: Cytoplasm
Caution: This is the ortholog of mouse OASL1
Sequence caution: Sequence=AAC41733.1; Type=Frameshift; Positions=386;
1 PDB 3D structure from  and Proteopedia  for OASL:1WH3 (3D)
Secondary accessions: O75686 Q17R95 Q9Y6K6 Q9Y6K7Alternative splicing: 2 isoforms: Q15646-1 Q15646-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for OASL: NX_Q15646
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15646
OASL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001248754.1 NP_003724.1 NP_937856.1
ENSEMBL proteins: ENSP00000257570 ENSP00000341125 ENSP00000444127 Reactome Protein details: Q15646
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
OASL for ontologies About GeneDecksing
OASL Antibody Products:
Assay Products for OASL: |
Protein
Domains /
Families
for OASL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OASL for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q15646ProtoNet protein and cluster: Q15646 2 Blocks protein families: IPB000626 Ubiquitin domain IPB006117 2-5-oligoadenylate synthetase
UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646Domain: The ubiquitin-like domains are essential for its antiviral activitySimilarity: Belongs to the 2-5A synthase familySimilarity: Contains 2 ubiquitin-like domains |
Function
for OASL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646Function: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity againstencephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent ofRNase LInduction: By type I interferon (IFN) and viruses Genatlas biochemistry entry for OASL:2',5' oligoadenylate synthetase-like,interferon induced,cytoplasmic and nucleolar
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OASL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for OASL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OASL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OASL |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
OASL for ontologies About GeneDecksing
|
Pathways & Interactions
for OASL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Expression of IFN-induced genes | | | 2 | Interferon gamma signaling | | | 3 | Cytokine Signaling in Immune system | | | 4 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 
Reactome Pathways for OASL (see all 7)
OASL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OASL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/58 Interacting proteins for OASL (Q156463 ENSP000002575704) via UniProtKB, MINT, STRING, and/or I2D (see all 58)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
OASL for ontologies About GeneDecksing
|
Drugs & Compounds
for OASL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
OASL for compounds About GeneDecksing
 Browse Tocris compounds for OASL
1 Novoseek chemical compound relationship for OASL gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 2',5'-oligoadenylate |
90.1 |
10 |
14728690 (3), 9722630 (2), 10087211 (1), 20074559 (1) |
Search CenterWatch for drugs/clinical trials and news about OASL
|
Transcripts
for OASL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OASL gene (3 alternative transcripts): NM_001261825.1 NM_003733.3 NM_198213.2 Unigene Cluster for OASL: 2'-5'-oligoadenylate synthetase-like Hs.118633 [show with all ESTs]Unigene Representative Sequence: NM_0037333 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000257570(uc001tzj.1 uc001tzk.1) ENST00000339275 ENST00000543677
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OASL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OASL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): OASL (NM_003733) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OASL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OASL |
Additional cDNA sequence: AJ225089.1 AK023956.1 AK314419.1 BC117408.1 BC117410.1 JQ792168.1 5 DOTS entries: DT.307381 DT.100748407 DT.40228111 DT.95159820 DT.86847026 24/75 AceView cDNA sequences (see all 75): BM909951 NM_003733 BP381869 BI822276 AL711263 AW069118 NM_198213 BM769452 CB125965 BU542269 CR609351 AA115392 BU535430 CA431656 AL555026 BG744291 BE784824 AU142043 CD370825 AJ225089 BG744279 CB127001 AV725389 CA309009
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for OASL About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for OASL
|
Expression
for OASL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OASL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCAAAGCC
About this image
See OASL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OASL
SOURCE GeneReport for Unigene cluster: Hs.118633
UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646Tissue specificity: Expressed in most tissues, with the highest levels in primary blood Leukocytes and otherhematopoietic system tissues, colon, stomach and to some extent in testis
SABiosciences Custom PCR Arrays for OASL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OASL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OASL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OASL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OASL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OASL |
Orthologs
for OASL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OASL gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for OASL (if available)
TreeFam Gene Tree for OASL (if available) |
Paralogs
for OASL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OASL gene
- OAS22 OAS12 OAS32
3 SIMAP similar genes for OASL using alignment to 2 protein entries: OASL_HUMAN (see all proteins):OASLd OAS3 OAS1
OASL for paralogs About GeneDecksing
|
Genomic Variants
for OASL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OASL (121458095 - 121477045 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OASL
1 CNV: 3899 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OASL |
|
Disorders
/ Diseases
for OASL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OASL for disorders About GeneDecksing
OMIM gene information: 603281
OMIM disorders: --
11  diseases for OASL: About MalaCardstick-borne encephalitis west nile virus dengue hemorrhagic fever hemorrhagic fever
thyroiditis systemic lupus erythematosus lupus erythematosus encephalitis
hepatitis c hepatitis b hepatitis
2 diseases from the University of Copenhagen DISEASES database for OASL:West Nile encephalitis Avian influenza Genetic Association Database (GAD): OASL
Human Genome Epidemiology (HuGE) Navigator: OASL (7 documents)
Export disorders for OASL gene to outside databases
|
Publications
for OASL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OASL gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with OASL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. (PubMed id 14728690)1, 2, 9 Andersen J.B.... Justesen J. (2004)
- 2',5'-Oligoadenylate synthetase-like gene highly indu ced by hepatitis C virus infection in human liver is inhibitory to viral replic ation in vitro. (PubMed id 20074559)1, 2, 9 Ishibashi M....Esumi M. (2010)
- p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. (PubMed id 9722630)1, 2, 9 Hartmann R.... Justesen J. (1998)
- The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. (PubMed id 10087211)1, 3, 9 Hovnanian A....Hovanessian A.G. (1999)
- Differential regulation of the OASL and OAS1 genes in response to viral infections. (PubMed id 19203244)1, 2 Melchjorsen J....Hartmann R. (2009)
- The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain. (PubMed id 18931074)1, 2 Marques J....Hartmann R. (2008)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection. (PubMed id 16235172)1, 4 Yakub I....Tweardy D.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning and characterization of two related and interferon- induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase. (PubMed id 9826176)1, 2 Rebouillat D.... Hovanessian A.G. (1998)
|
External Searches for OASL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OASL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OASL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OASL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OASL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OASL gene:
Search GeneIP for patents involving OASL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OASL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OASL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OASL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OASL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OASL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OASL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OASL |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OASL |
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