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OASL Gene

protein-coding   GIFtS: 61
GCID: GC12M121459

2'-5'-Oligoadenylate Synthetase-Like

  See OASL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
2'-5'-Oligoadenylate Synthetase-Like1 2     P59 OASL2 3
TRIP142 3 5     p59OASL2 3
Thyroid Receptor-Interacting Protein 142 3     TR-Interacting Protein 142 3
2'-5'-OAS-RP2 3     2'-5'-Oligoadenylate Synthase-Like Protein2
2'-5'-OAS-Related Protein2 3     59 KDa 2'-5'-Oligoadenylate Synthetase-Like Protein2
59 KDa 2'-5'-Oligoadenylate Synthase-Like Protein2 3     OASLd2
TRIP-142 3     p59-OASL2

External Ids:    HGNC: 80901   Entrez Gene: 86382   Ensembl: ENSG000001351147   OMIM: 6032815   UniProtKB: Q156463   

Export aliases for OASL gene to outside databases

Previous GC identifers: GC12M120319 GC12M121055 GC12M121240 GC12M119870 GC12M119920 GC12M118466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OASL Gene:
OASL (2'-5'-oligoadenylate synthetase-like) is a protein-coding gene. Diseases associated with OASL include west nile encephalitis. GO annotations related to this gene include double-stranded RNA binding and 2'-5'-oligoadenylate synthetase activity. An important paralog of this gene is OAS2.

UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646
Function: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against
encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of
RNase L

Gene Wiki entry for OASL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OASL gene promoter:
         Elk-1   RFX1   STAT1beta   Olf-1   STAT1alpha   PPAR-gamma1   IRF-2   NRF-2   Ik-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OASL promoter sequence
   Search Chromatin IP Primers for OASL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OASL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.2

OASL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OASL gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M121459:  view genomic region     (about GC identifiers)

Start:
121,458,095 bp from pter      End:
121,477,045 bp from pter
Size:
18,951 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646 (See protein sequence)
Recommended Name: 2'-5'-oligoadenylate synthase-like protein  
Size: 514 amino acids; 59226 Da
Subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not
require the presence of thyroid hormone for its interaction. Binds MBD1
Caution: This is the ortholog of mouse OASL1
Sequence caution: Sequence=AAC41733.1; Type=Frameshift; Positions=386;
1 PDB 3D structure from and Proteopedia for OASL:
1WH3 (3D)    
Secondary accessions: B2RAZ2 I1YDD2 O75686 Q17R95 Q9Y6K6 Q9Y6K7
Alternative splicing: 3 isoforms:  Q15646-1   Q15646-2   Q15646-3   (Has antiviral activity against RNA viruses)

Explore the universe of human proteins at neXtProt for OASL: NX_Q15646

Explore proteomics data for OASL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OASL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001248754.1  NP_003724.1  NP_937856.1  

    ENSEMBL proteins: 
     ENSP00000257570   ENSP00000341125   ENSP00000444127  
    Reactome Protein details: Q15646

    OASL Human Recombinant Protein Products:

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    antibodies-online peptides for OASL

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR018952 2-5-oligoAdlate_synth_1_dom2/C
     IPR006117 2-5-oligoadenylate_synth_CS
     IPR000626 Ubiquitin_dom
     IPR006116 2-5-oligoadenylate_synth_N
     IPR026774 2-5A_synthase

    Graphical View of Domain Structure for InterPro Entry Q15646

    ProtoNet protein and cluster: Q15646

    2 Blocks protein domains:
    IPB000626 Ubiquitin domain
    IPB006117 2-5-oligoadenylate synthetase


    UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646
    Domain: The ubiquitin-like domains are essential for its antiviral activity
    Similarity: Belongs to the 2-5A synthase family
    Similarity: Contains 2 ubiquitin-like domains


    Find genes that share domains with OASL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OASL_HUMAN, Q15646
    Function: Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against
    encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of
    RNase L
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for OASL:
    2',5' oligoadenylate synthetase-like,interferon induced,cytoplasmic and nucleolar

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001730NOT 2'-5'-oligoadenylate synthetase activity IDA9826176
    GO:0003677DNA binding IDA9826176
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IDA9826176
    GO:0005515protein binding ----
         
    Find genes that share ontologies with OASL           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Oasl1):
     homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with OASL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Oasl1tm1Yjk for OASL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OASL
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    miRTarBase miRNAs that target OASL:
    hsa-mir-1 (MIRT023766), hsa-mir-146a-5p (MIRT021250), hsa-mir-124-3p (MIRT022684)

    Block miRNA regulation of human, mouse, rat OASL using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OASL_HUMAN, Q15646: Isoform p56: Nucleus, nucleolus. Cytoplasm
    OASL_HUMAN, Q15646: Isoform p30: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA9826176
    GO:0005737cytoplasm IDA9826176
    GO:0005829cytosol TAS--

    Find genes that share ontologies with OASL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OASL About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43


    Find genes that share SuperPaths with OASL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for OASL
        Interferon alpha/beta signaling
    Interferon gamma signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OASL
    Interactions:

        Search GeneGlobe Interaction Network for OASL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OASL (Q156463 ENSP000002575704) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MBD1Q9UIS93, ENSP000002694684I2D: score=2 STRING: ENSP00000269468
    THRAP108273, ENSP000002646374I2D: score=1 STRING: ENSP00000264637
    ADARENSP000003574594STRING: ENSP00000357459
    B2MENSP000003408584STRING: ENSP00000340858
    ENSG00000206435ENSP000003729754STRING: ENSP00000372975
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ----
    GO:0009615response to virus IDA18931074
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0045071negative regulation of viral genome replication IDA18931074
    GO:0051607defense response to virus IEA--

    Find genes that share ontologies with OASL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OASL

    1 Novoseek inferred chemical compound relationship for OASL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 90.1 10 14728690 (3), 9722630 (2), 10087211 (1), 20074559 (1)

    2 PharmGKB related drug/compound annotations for OASL gene    About this table
    Drug/compound PharmGKB Annotation
    peginterferon alfa-2bCA  
    ribavirinCA  



    Find genes that share compounds with OASL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OASL gene (3 alternative transcripts): 
    NM_001261825.1  NM_003733.3  NM_198213.2  

    Unigene Cluster for OASL:

    2'-5'-oligoadenylate synthetase-like
    Hs.118633  [show with all ESTs]
    Unigene Representative Sequence: NM_003733
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257570(uc001tzj.1 uc001tzk.1) ENST00000339275 ENST00000543677

    miRNA
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    Additional mRNA sequence: 

    AJ225089.1 AK023956.1 AK314419.1 BC117408.1 BC117410.1 JQ792168.1 

    5 DOTS entries:

    DT.307381  DT.100748407  DT.40228111  DT.95159820  DT.86847026 

    Selected AceView cDNA sequences (see all 75):

    NM_198213 BM909951 CR609351 AL711263 BP381869 BM769452 CB125965 BI822276 
    NM_003733 BU542269 AW069118 BI822608 BP378298 CD366552 BG744291 AL555026 
    CA309009 BG339739 BM043278 CD370825 BM836429 CA309476 CB150660 CA307835 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OASL    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
    SP1:                                                            
    SP2:                                -                           
    SP3:                    -           -                           


    ECgene alternative splicing isoforms for OASL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OASL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAAAGCC
    OASL Expression
    About this image


    OASL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    OASL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OASL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.118633

    UniProtKB/Swiss-Prot: OASL_HUMAN, Q15646
    Tissue specificity: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other
    hematopoietic system tissues, colon, stomach and to some extent in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OASL gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oasl11 , 5 2'-5' oligoadenylate synthetase-like 11, 5 77.52(n)1
    70.98(a)1
      5 (55.99 cM)5
    2316551  NM_145209.31  NP_660210.11 
     1149232405 
    chicken
    (Gallus gallus)
    Aves OAS*A6
    Gallus gallus 2'-5'-oligoadenylate synthetase-like...
    36(a)
    1 ↔ 1
    12(3226270-3228218)
    lizard
    (Anolis carolinensis)
    Reptilia OASL6
    2'-5'-oligoadenylate synthetase-like
    42(a)
    1 ↔ 1
    2(149229017-149246231)


    ENSEMBL Gene Tree for OASL (if available)
    TreeFam Gene Tree for OASL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OASL gene
    OAS22  OAS12  OAS32  
    2 SIMAP similar genes for OASL using alignment to 2 protein entries:     OASL_HUMAN (see all proteins):
    OAS3    OAS1

    Find genes that share paralogs with OASL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OASL (see all 521)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs747365521,2
    C--121457618(+) GGCTGG/TTGGTA 3 -- int10--------
    rs1384058861,2
    --121457625(+) GGTATA/GGGGAA 3 -- int10--------
    rs1438916091,2
    --121457831(+) CTGTGC/TGTCAT 3 -- int10--------
    rs22596901,2
    C,F,A,H--121457914(-) AAAAAA/CAGGAT 3 -- int116Minor allele frequency- N:0.01EA NA NS WA CSA 1021
    rs1472460331,2
    --121457961(+) ACACAA/GGGTCT 3 -- int10--------
    rs1407073061,2
    --121457982(+) CCTGGG/TCAGGA 3 -- int10--------
    rs22596931,2
    C,F,A,H--121457995(-) CACACC/TGCTAC 3 -- int119Minor allele frequency- T:0.50NS EA NA WA CSA 1361
    rs1867086091,2
    --121458019(+) GCAGCG/TTCAGC 3 -- int10--------
    rs289694911,2
    C--121458107(+) TTTTTT/-ATTTT 3 -- ut312Minor allele frequency- -:0.19NS CSA 429
    rs1926271711,2
    --121458126(+) AGAGAC/TGGGGT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for OASL (121458095 - 121477045 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OASL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521928CNV Gain19592680
    nsv899559CNV Gain21882294
    nsv832531CNV Gain17160897
    dgv1496n71CNV Gain21882294
    dgv529e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603281    OMIM disorders: --

    1 disease for OASL:    
    About MalaCards
    west nile encephalitis

    1 disease from the University of Copenhagen DISEASES database for OASL:
    West Nile encephalitis

    Find genes that share disorders with OASL           About GenesLikeMe

    Genetic Association Database (GAD): OASL
    Human Genome Epidemiology (HuGE) Navigator: OASL (7 documents)

    Export disorders for OASL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OASL gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with OASL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. (PubMed id 14728690)1, 2, 9 Andersen J.B.... Justesen J. (Eur. J. Biochem. 2004)
    2. 2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. (PubMed id 20074559)1, 2, 9 Ishibashi M.... Esumi M. (Biochem. Biophys. Res. Commun. 2010)
    3. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. (PubMed id 9722630)1, 2, 9 Hartmann R.... Justesen J. (Nucleic Acids Res. 1998)
    4. The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. (PubMed id 10087211)1, 3, 9 Hovnanian A....Hovanessian A.G. (Genomics 1999)
    5. Identification of OASL d, a splice variant of human OASL, with antiviral activity. (PubMed id 22531715)1, 2 Guo X.... Li E. (Int. J. Biochem. Cell Biol. 2012)
    6. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PubMed id 21943158)1, 4 Middelberg R.P....Whitfield J.B. (BMC Med. Genet. 2011)
    7. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    8. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1, 4 Voight B.F.... . (Nat. Genet. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. (PubMed id 21050126)1, 4 Barkhash A.V....Brinton M.A. (J. Infect. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8638 HGNC: 8090 AceView: OASL Ensembl:ENSG00000135114 euGenes: HUgn8638
    ECgene: OASL H-InvDB: OASL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OASL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OASL gene:
    Search GeneIP for patents involving OASL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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