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Aliases for OASL Gene

Aliases for OASL Gene

  • 2'-5'-Oligoadenylate Synthetase Like 2
  • 2-5-Oligoadenylate Synthetase Like 2 3 5
  • 59 KDa 2-5-Oligoadenylate Synthase-Like Protein 3 4
  • Thyroid Receptor-Interacting Protein 14 3 4
  • TR-Interacting Protein 14 3 4
  • 2-5-OAS-Related Protein 3 4
  • 2-5-OAS-RP 3 4
  • P59 OASL 3 4
  • TRIP-14 3 4
  • P59OASL 3 4
  • TRIP14 3 4
  • 59 KDa 2-5-Oligoadenylate Synthetase-Like Protein 3
  • 2-5-Oligoadenylate Synthase-Like Protein 3
  • 2-5-Oligoadenylate Synthetase-Like 2
  • P59-OASL 3
  • OASLd 3

External Ids for OASL Gene

Previous GeneCards Identifiers for OASL Gene

  • GC12M120319
  • GC12M121240
  • GC12M119870
  • GC12M119920
  • GC12M121459
  • GC12M118466

Summaries for OASL Gene

GeneCards Summary for OASL Gene

OASL (2'-5'-Oligoadenylate Synthetase Like) is a Protein Coding gene. Diseases associated with OASL include Microphthalmia With Limb Anomalies. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include poly(A) RNA binding and double-stranded RNA binding. An important paralog of this gene is OAS1.

UniProtKB/Swiss-Prot for OASL Gene

  • Does not have 2-5-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

Gene Wiki entry for OASL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OASL Gene

Genomics for OASL Gene

Regulatory Elements for OASL Gene

Enhancers for OASL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G121059 1.4 FANTOM5 Ensembl ENCODE 50.6 -21.2 -21166 1.8 HDGF PKNOX1 ZBTB40 RAD21 YY1 ZNF143 ZNF207 RELB IKZF2 THAP11 OASL P2RX4 P2RX7 C12orf43 SPPL3 ACADS ENSG00000256569 CAMKK2 LOC105378258
GH12G121276 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -239.1 -239051 3.8 HDGF ATF1 SIN3A GLI4 FEZF1 YY1 ZNF121 FOS DEK ZNF263 P2RX4 CAMKK2 OASL P2RX7 LOC105370032
GH12G120958 1.6 Ensembl ENCODE dbSUPER 11.2 +78.2 78169 5.5 HDGF PKNOX1 ARNT CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 ACADS C12orf43 SPPL3 OASL ENSG00000256569 ENSG00000255946 UNC119B MLEC ENSG00000256364 P2RX4
GH12G121196 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.1 -158.0 -157968 1.5 BCOR ATF1 JUN ZSCAN4 ZNF175 ZMYM3 MAX ZNF121 GATA2 EED P2RX4 P2RX7 CAMKK2 ENSG00000256569 ACADS OASL ENSG00000274029
GH12G121143 2 FANTOM5 Ensembl ENCODE dbSUPER 7.3 -105.3 -105311 3.0 PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF766 FOS ZNF263 SP3 JUNB P2RX4 SETD1B P2RX7 HNF1A-AS1 CAMKK2 OASL ENSG00000257053
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OASL on UCSC Golden Path with GeneCards custom track

Promoters for OASL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058398 42 801 TBP PKNOX1 ATF1 WRNIP1 SIN3A RAD21 YY1 ZNF143 ZNF207 RELB

Genomic Location for OASL Gene

Chromosome:
12
Start:
121,019,111 bp from pter
End:
121,039,242 bp from pter
Size:
20,132 bases
Orientation:
Minus strand

Genomic View for OASL Gene

Genes around OASL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OASL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OASL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OASL Gene

Proteins for OASL Gene

  • Protein details for OASL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15646-OASL_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase-like protein
    Protein Accession:
    Q15646
    Secondary Accessions:
    • B2RAZ2
    • I1YDD2
    • O75686
    • Q17R95
    • Q9Y6K6
    • Q9Y6K7

    Protein attributes for OASL Gene

    Size:
    514 amino acids
    Molecular mass:
    59226 Da
    Quaternary structure:
    • Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1.
    SequenceCaution:
    • Sequence=AAC41733.1; Type=Frameshift; Positions=386; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OASL Gene

    Alternative splice isoforms for OASL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OASL Gene

Post-translational modifications for OASL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OASL Gene

No data available for DME Specific Peptides for OASL Gene

Domains & Families for OASL Gene

Suggested Antigen Peptide Sequences for OASL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15646

UniProtKB/Swiss-Prot:

OASL_HUMAN :
  • The ubiquitin-like domains are essential for its antiviral activity.
  • Belongs to the 2-5A synthase family.
Domain:
  • The ubiquitin-like domains are essential for its antiviral activity.
Family:
  • Belongs to the 2-5A synthase family.
genes like me logo Genes that share domains with OASL: view

No data available for Gene Families for OASL Gene

Function for OASL Gene

Molecular function for OASL Gene

GENATLAS Biochemistry:
2,5 oligoadenylate synthetase-like,interferon induced,cytoplasmic and nucleolar
UniProtKB/Swiss-Prot Function:
Does not have 2-5-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses.

Gene Ontology (GO) - Molecular Function for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 NOT 2-5-oligoadenylate synthetase activity IDA 9826176
GO:0003677 DNA binding IDA 9826176
GO:0003723 RNA binding IDA 22658674
GO:0003725 double-stranded RNA binding IDA 9826176
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with OASL: view
genes like me logo Genes that share phenotypes with OASL: view

Animal Models for OASL Gene

MGI Knock Outs for OASL:

Animal Model Products

CRISPR Products

miRNA for OASL Gene

miRTarBase miRNAs that target OASL

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OASL Gene

Localization for OASL Gene

Subcellular locations from UniProtKB/Swiss-Prot for OASL Gene

Isoform p56: Nucleus, nucleolus. Cytoplasm.
Isoform p30: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OASL gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA,IDA 9826176
GO:0005737 cytoplasm IDA,IEA 9826176
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OASL: view

Pathways & Interactions for OASL Gene

genes like me logo Genes that share pathways with OASL: view

Gene Ontology (GO) - Biological Process for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0009615 response to virus IDA 18931074
GO:0045071 negative regulation of viral genome replication IDA 18931074
GO:0045087 innate immune response IEA --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with OASL: view

No data available for SIGNOR curated interactions for OASL Gene

Drugs & Compounds for OASL Gene

(2) Drugs for OASL Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2b Approved Pharma 307
Ribavirin Approved Pharma 1003

(1) Additional Compounds for OASL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OASL: view

Transcripts for OASL Gene

Unigene Clusters for OASL Gene

2-5-oligoadenylate synthetase-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OASL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1:
SP2: -
SP3: - -

Relevant External Links for OASL Gene

GeneLoc Exon Structure for
OASL
ECgene alternative splicing isoforms for
OASL

Expression for OASL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OASL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OASL Gene

This gene is overexpressed in Whole Blood (x18.0).

Protein differential expression in normal tissues from HIPED for OASL Gene

This gene is overexpressed in Lung (53.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OASL Gene



NURSA nuclear receptor signaling pathways regulating expression of OASL Gene:

OASL

SOURCE GeneReport for Unigene cluster for OASL Gene:

Hs.118633

mRNA Expression by UniProt/SwissProt for OASL Gene:

Q15646-OASL_HUMAN
Tissue specificity: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis.

Evidence on tissue expression from TISSUES for OASL Gene

  • Blood(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with OASL: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OASL Gene

Orthologs for OASL Gene

This gene was present in the common ancestor of chordates.

Orthologs for OASL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OASL 34 35
  • 99.35 (n)
rat
(Rattus norvegicus)
Mammalia Oasl 34
  • 78.33 (n)
mouse
(Mus musculus)
Mammalia Oasl1 34 16 35
  • 77.52 (n)
dog
(Canis familiaris)
Mammalia OASL1 35
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OASL 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OASL 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves OAS*A 35
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OASL 35
  • 42 (a)
OneToOne
Species where no ortholog for OASL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OASL Gene

ENSEMBL:
Gene Tree for OASL (if available)
TreeFam:
Gene Tree for OASL (if available)

Paralogs for OASL Gene

Paralogs for OASL Gene

(2) SIMAP similar genes for OASL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OASL: view

Variants for OASL Gene

Sequence variations from dbSNP and Humsavar for OASL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000201669 -- 121,025,385(+) AAATA(C/T)TGAAT intron-variant
rs1000308630 -- 121,021,509(+) TCTTT(C/T)CAGAA intron-variant
rs1000424759 -- 121,031,829(+) ATGCA(A/T)CAGAC intron-variant
rs1000480630 -- 121,026,839(+) AGAGC(A/G)AAACT intron-variant
rs1000532486 -- 121,027,053(+) GGATA(G/T)GAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OASL Gene

Variant ID Type Subtype PubMed ID
esv2759917 CNV loss 17122850
nsv1039216 CNV gain 25217958
nsv521928 CNV gain 19592680
nsv560454 CNV loss 21841781
nsv832531 CNV gain 17160897

Variation tolerance for OASL Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OASL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OASL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OASL Gene

Disorders for OASL Gene

MalaCards: The human disease database

(1) MalaCards diseases for OASL Gene - From: DISEASES

Disorder Aliases PubMed IDs
microphthalmia with limb anomalies
  • anophthalmia-syndactyly syndrome
- elite association - COSMIC cancer census association via MalaCards
Search OASL in MalaCards View complete list of genes associated with diseases

Relevant External Links for OASL

Genetic Association Database (GAD)
OASL
Human Genome Epidemiology (HuGE) Navigator
OASL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OASL
genes like me logo Genes that share disorders with OASL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OASL Gene

Publications for OASL Gene

  1. 2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. (PMID: 20074559) Ishibashi M. … Esumi M. (Biochem. Biophys. Res. Commun. 2010) 3 4 22 64
  2. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. (PMID: 14728690) Andersen J.B. … Justesen J. (Eur. J. Biochem. 2004) 3 4 22 64
  3. The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. (PMID: 10087211) Hovnanian A. … Hovanessian A.G. (Genomics 1999) 2 3 22 64
  4. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. (PMID: 9722630) Hartmann R. … Justesen J. (Nucleic Acids Res. 1998) 3 4 22 64
  5. Identification of OASL d, a splice variant of human OASL, with antiviral activity. (PMID: 22531715) Guo X. … Li E. (Int. J. Biochem. Cell Biol. 2012) 3 4 64

Products for OASL Gene

Sources for OASL Gene

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