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Aliases for OAS3 Gene

Aliases for OAS3 Gene

  • 2'-5'-Oligoadenylate Synthetase 3 2
  • 2-5-Oligoadenylate Synthetase 3 2 3 5
  • 2-5-Oligoadenylate Synthetase 3, 100kDa 2 3
  • (2-5)Oligo(A) Synthase 3 3 4
  • 2-5A Synthase 3 3 4
  • P100 OAS 3 4
  • P100OAS 3 4
  • 2-5-Oligoadenylate Synthetase 3 (100 KD) 2
  • 2-5oligoadenylate Synthetase P100 3
  • (2-5)Oligo(A) Synthetase 3 3
  • 2-5A Synthetase 3 3
  • EC 2.7.7.84 4
  • EC 2.7.7 63
  • P100 3

External Ids for OAS3 Gene

Previous GeneCards Identifiers for OAS3 Gene

  • GC12P112271
  • GC12P112895
  • GC12P113159
  • GC12P111788
  • GC12P111838
  • GC12P113376
  • GC12P110388

Summaries for OAS3 Gene

Entrez Gene Summary for OAS3 Gene

  • This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

GeneCards Summary for OAS3 Gene

OAS3 (2'-5'-Oligoadenylate Synthetase 3) is a Protein Coding gene. Diseases associated with OAS3 include chikungunya and tick-borne encephalitis. Among its related pathways are Hepatitis C and Influenza A. GO annotations related to this gene include RNA binding and transferase activity. An important paralog of this gene is OAS2.

UniProtKB/Swiss-Prot for OAS3 Gene

  • Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

Gene Wiki entry for OAS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAS3 Gene

Genomics for OAS3 Gene

Regulatory Elements for OAS3 Gene

Enhancers for OAS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OAS3 on UCSC Golden Path with GeneCards custom track

Promoters for OAS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OAS3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the OAS3 gene promoter:

Genomic Location for OAS3 Gene

Chromosome:
12
Start:
112,938,352 bp from pter
End:
112,973,249 bp from pter
Size:
34,898 bases
Orientation:
Plus strand

Genomic View for OAS3 Gene

Genes around OAS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAS3 Gene

Proteins for OAS3 Gene

  • Protein details for OAS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6K5-OAS3_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase 3
    Protein Accession:
    Q9Y6K5
    Secondary Accessions:
    • Q2HJ14
    • Q9H3P5

    Protein attributes for OAS3 Gene

    Size:
    1087 amino acids
    Molecular mass:
    121170 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAD28543.1; Type=Frameshift; Positions=394, 398; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OAS3 Gene

neXtProt entry for OAS3 Gene

Proteomics data for OAS3 Gene at MOPED

Selected DME Specific Peptides for OAS3 Gene

Post-translational modifications for OAS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAS3 Gene

Antibody Products

Domains & Families for OAS3 Gene

Suggested Antigen Peptide Sequences for OAS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6K5

UniProtKB/Swiss-Prot:

OAS3_HUMAN :
  • Belongs to the 2-5A synthase family.
Family:
  • Belongs to the 2-5A synthase family.
genes like me logo Genes that share domains with OAS3: view

No data available for Gene Families for OAS3 Gene

Function for OAS3 Gene

Molecular function for OAS3 Gene

GENATLAS Biochemistry:
2,5-oligoadenylate synthetase 3,100kDa,ubiquitously expressed ,interferon induced
UniProtKB/Swiss-Prot CatalyticActivity:
3 ATP = pppA2p5A2p5A + 2 diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators.
UniProtKB/Swiss-Prot Function:
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
UniProtKB/Swiss-Prot Induction:
By type I interferon (IFN) and viruses.

Enzyme Numbers (IUBMB) for OAS3 Gene

Gene Ontology (GO) - Molecular Function for OAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 2-5-oligoadenylate synthetase activity IDA 9880533
GO:0005524 ATP binding IEA,IDA 9880533
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with OAS3: view
genes like me logo Genes that share phenotypes with OAS3: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OAS3 Gene

Localization for OAS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAS3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OAS3 Gene COMPARTMENTS Subcellular localization image for OAS3 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for OAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9880533
genes like me logo Genes that share ontologies with OAS3: view

Pathways & Interactions for OAS3 Gene

genes like me logo Genes that share pathways with OAS3: view

Gene Ontology (GO) - Biological Process for OAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0009615 response to virus IDA 19056102
GO:0051607 defense response to virus IEA,IDA 19923450
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with OAS3: view

No data available for SIGNOR curated interactions for OAS3 Gene

Drugs & Compounds for OAS3 Gene

(1) Drugs for OAS3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for OAS3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OAS3: view

Transcripts for OAS3 Gene

Unigene Clusters for OAS3 Gene

2-5-oligoadenylate synthetase 3, 100kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OAS3 Gene

No ASD Table

Relevant External Links for OAS3 Gene

GeneLoc Exon Structure for
OAS3
ECgene alternative splicing isoforms for
OAS3

Expression for OAS3 Gene

mRNA expression in normal human tissues for OAS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OAS3 Gene

This gene is overexpressed in Nasal epithelium (23.5) and Stomach (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OAS3 Gene



SOURCE GeneReport for Unigene cluster for OAS3 Gene Hs.744211

mRNA Expression by UniProt/SwissProt for OAS3 Gene

Q9Y6K5-OAS3_HUMAN
Tissue specificity: Present at high level in placenta trophoblast.
genes like me logo Genes that share expression patterns with OAS3: view

Protein tissue co-expression partners for OAS3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for OAS3 Gene

Orthologs for OAS3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OAS3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OAS3 35
  • 82.8 (n)
  • 78.47 (a)
OAS3 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oas3 35
  • 75.89 (n)
  • 70.66 (a)
Oas3 16
Oas3 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OAS3 35
  • 99.57 (n)
  • 99.36 (a)
OAS3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oas3 35
  • 75.46 (n)
  • 70.02 (a)
oppossum
(Monodelphis domestica)
Mammalia OAS3 36
  • 57 (a)
OneToOne
Species with no ortholog for OAS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OAS3 Gene

ENSEMBL:
Gene Tree for OAS3 (if available)
TreeFam:
Gene Tree for OAS3 (if available)

Paralogs for OAS3 Gene

Paralogs for OAS3 Gene

(3) SIMAP similar genes for OAS3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OAS3: view

Variants for OAS3 Gene

Sequence variations from dbSNP and Humsavar for OAS3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12819767 - 112,941,585(+) CGGGC(C/T)GGGGC reference, missense
rs2285933 - 112,948,974(-) GGTTT(C/G)CTCCC reference, missense
rs16942374 - 112,965,946(+) TCCCC(A/G)CGTGC reference, missense
rs1859330 -, -, - 112,938,583(-) GCAGC(A/C/G/T)TTCTG reference, missense
rs45519442 - 112,948,964(+) CCCAA(A/G)AGCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OAS3 Gene

Variant ID Type Subtype PubMed ID
nsv832516 CNV Gain 17160897
nsv515628 CNV Loss 19592680

Variation tolerance for OAS3 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.65; 72.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OAS3 Gene

HapMap Linkage Disequilibrium report
OAS3
Human Gene Mutation Database (HGMD)
OAS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAS3 Gene

Disorders for OAS3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OAS3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chikungunya
  • chikungunya fever
tick-borne encephalitis
  • central european encephalitis
west nile encephalitis
  • west nile fever encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search OAS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OAS3

Genetic Association Database (GAD)
OAS3
Human Genome Epidemiology (HuGE) Navigator
OAS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OAS3
genes like me logo Genes that share disorders with OAS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OAS3 Gene

Publications for OAS3 Gene

  1. The large form of human 2',5'-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus. (PMID: 19056102) Brehin A.C. … Despres P. (Virology 2009) 3 4 23 67
  2. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PMID: 19923450) Lin R.J. … Lin Y.L. (J. Immunol. 2009) 3 23
  3. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PMID: 16014697) Tessier M.C. … Polychronakos C. (J. Med. Genet. 2006) 3 23
  4. Characterization of the gene encoding the 100-kDa form of human 2', 5'oligoadenylate synthetase. (PMID: 11112351) Rebouillat D. … Williams B.R. (Genomics 2000) 3 23
  5. The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. (PMID: 9790745) Hovnanian A. … Hovanessian A.G. (Genomics 1998) 2 3

Products for OAS3 Gene

Sources for OAS3 Gene

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