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OAS3 Gene

protein-coding   GIFtS: 56
GCID: GC12P113376

2'-5'-Oligoadenylate Synthetase 3, 100kDa

(Previous name: 2'-5'-oligoadenylate synthetase 3 (100 kD))
  See OAS3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
2'-5'-Oligoadenylate Synthetase 3, 100kDa1 2     2'-5'-Oligoadenylate Synthase 32
(2-5')Oligo(A) Synthase 32 3     2'-5'Oligoadenylate Synthetase P1002
2-5A Synthase 32 3     2-5A Synthetase 32
P100 OAS2 3     p1002
p100OAS2 3     EC 2.7.7.843
2'-5'-Oligoadenylate Synthetase 3 (100 KD)1     EC 2.7.78
(2-5')Oligo(A) Synthetase 32     

External Ids:    HGNC: 80881   Entrez Gene: 49402   Ensembl: ENSG000001113317   OMIM: 6033515   UniProtKB: Q9Y6K53   

Export aliases for OAS3 gene to outside databases

Previous GC identifers: GC12P112271 GC12P112895 GC12P113159 GC12P111788 GC12P111838 GC12P110388


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OAS3 Gene:
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by
interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme
family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
(provided by RefSeq, Jul 2008)

GeneCards Summary for OAS3 Gene:
OAS3 (2'-5'-oligoadenylate synthetase 3, 100kDa) is a protein-coding gene. Diseases associated with OAS3 include chikungunya, and west nile encephalitis. GO annotations related to this gene include double-stranded RNA binding and 2'-5'-oligoadenylate synthetase activity. An important paralog of this gene is OAS2.

UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate
antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell
growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A)
from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization
and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting
in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via
the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays
antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus
(SFV)

Gene Wiki entry for OAS3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OAS3 gene promoter:
         HEN1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOAS3 promoter sequence
   Search Chromatin IP Primers for OAS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OAS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.2

OAS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAS3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113376:  view genomic region     (about GC identifiers)

Start:
113,376,157 bp from pter      End:
113,411,054 bp from pter
Size:
34,898 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5 (See protein sequence)
Recommended Name: 2'-5'-oligoadenylate synthase 3  
Size: 1087 amino acids; 121170 Da
Cofactor: Magnesium (Potential)
Subunit: Monomer
Sequence caution: Sequence=AAD28543.1; Type=Frameshift; Positions=394, 398;
Secondary accessions: Q2HJ14 Q9H3P5

Explore the universe of human proteins at neXtProt for OAS3: NX_Q9Y6K5

Explore proteomics data for OAS3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for OAS3 (Q9Y6K5)
     LDPADPT  SDADLVVF  RPTKLKSLIRLVKHWYQ 


    See OAS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006178.2  
    ENSEMBL proteins: 
     ENSP00000228928   ENSP00000449299   ENSP00000448388   ENSP00000447323  
    Reactome Protein details: Q9Y6K5

    OAS3 Human Recombinant Protein Products:

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    Novus Biologicals OAS3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OAS3

     
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    Search antibodies-online for proteins for OAS3 

     
    antibodies-online peptides for OAS3

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    antibodies-online antibodies for OAS3 (27 products) 

    OAS3 Assay Products:

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    Cloud-Clone Corp. ELISAs for OAS3
    Cloud-Clone Corp. CLIAs for OAS3
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    antibodies-online kits for OAS3 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR002934 Nucleotidyltransferase
     IPR018952 2-5-oligoAdlate_synth_1_dom2/C
     IPR006117 2-5-oligoadenylate_synth_CS
     IPR006116 2-5-oligoadenylate_synth_N
     IPR026774 2-5A_synthase

    Graphical View of Domain Structure for InterPro Entry Q9Y6K5

    ProtoNet protein and cluster: Q9Y6K5

    2 Blocks protein domains:
    IPB002934 DNA polymerase
    IPB006117 2-5-oligoadenylate synthetase


    UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5
    Similarity: Belongs to the 2-5A synthase family


    Find genes that share domains with OAS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OAS3_HUMAN, Q9Y6K5
    Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate
    antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell
    growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A)
    from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization
    and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting
    in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via
    the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays
    antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus
    (SFV)
    Catalytic activity: 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate
    Enzyme regulation: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral
    infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group
    is tolerated. ssRNA or dsDNA do not act as activators
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for OAS3:
    2',5'-oligoadenylate synthetase 3,100kDa,ubiquitously expressed ,interferon induced

         Enzyme Numbers (IUBMB): EC 2.7.7.841 EC 2.7.72

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00017302'-5'-oligoadenylate synthetase activity IDA9880533
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IDA9880533
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IDA9880533
         
    Find genes that share ontologies with OAS3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OAS3

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate OAS3:
    hsa-miR-4324 hsa-miR-4307 hsa-miR-615-5p hsa-miR-4253 hsa-miR-3166 hsa-miR-138
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OAS3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for OAS3

    Clone
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    OriGene ORF clones in mouse, rat for OAS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OAS3 (NM_006187)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OAS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OAS3

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OAS3_HUMAN, Q9Y6K5: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with OAS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OAS3 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    3Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43
    4Hepatitis C
    Hepatitis C


    Find genes that share SuperPaths with OAS3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for OAS3
        Interferon alpha/beta signaling
    Interferon gamma signaling


    4 Kegg Pathways  (Kegg details for OAS3):
        Hepatitis C
    Measles
    Influenza A
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OAS3
    Interactions:

        Search GeneGlobe Interaction Network for OAS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OAS3 (Q9Y6K51, 3 ENSP000002289284) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFRD2Q128941, 3, ENSP000003989714EBI-6115729,EBI-6115935 I2D: score=1 STRING: ENSP00000398971
    FTSJ3Q8IY811, 3EBI-6115729,EBI-744088 I2D: score=1 
    DHX30Q7L2E31, 3, ENSP000003926014EBI-6115729,EBI-1211456 I2D: score=1 STRING: ENSP00000392601
    EIF6P565371, 3, ENSP000003635594EBI-6115729,EBI-372243 I2D: score=1 STRING: ENSP00000363559
    MAVSQ7Z4341, 3, ENSP000004019804EBI-6115729,EBI-995373 I2D: score=1 STRING: ENSP00000401980
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS2440675
    GO:0006955immune response ----
    GO:0009615response to virus IDA19056102
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0045071negative regulation of viral genome replication IDA19056102

    Find genes that share ontologies with OAS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OAS3

    1 HMDB Compound for OAS3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for OAS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 93.3 8 16014697 (1), 8454907 (1), 20084279 (1), 19056102 (1) (see all 6)



    Find genes that share compounds with OAS3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OAS3 gene: 
    NM_006187.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228928(uc001tug.3) ENST00000551007(uc001tue.3) ENST00000548514(uc001tuf.3)
    ENST00000546638 ENST00000546800 ENST00000546973 ENST00000549918
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate OAS3:
    hsa-miR-4324 hsa-miR-4307 hsa-miR-615-5p hsa-miR-4253 hsa-miR-3166 hsa-miR-138
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiFast Probe-based Assays in human, mouse, rat OAS3

    Selected AceView cDNA sequences (see all 277):

    BQ430582 CB123126 BU857070 CA455330 AA312111 BU956028 BM550512 BU145349 
    BU902141 BM808561 AK000608 BU190077 BU944625 BU539624 BM836505 BM810143 
    BM977099 BU957630 BU956885 AA836757 BQ279127 NM_006187 BM913534 BC012015 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OAS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCTGGTAC
    OAS3 Expression
    About this image

    OAS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OAS3 Protein Expression

    UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5
    Tissue specificity: Present at high level in placenta trophoblast

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OAS3 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oas31 , 5 2'-5' oligoadenylate synthetase 31, 5 75.89(n)1
    70.66(a)1
      5 (60.64 cM)5
    2467271  NM_145226.21  NP_660261.11 
     1207530985 


    ENSEMBL Gene Tree for OAS3 (if available)
    TreeFam Gene Tree for OAS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OAS3 gene
    OAS22  OASL2  OAS12  
    3 SIMAP similar genes for OAS3 using alignment to 5 protein entries:     OAS3_HUMAN (see all proteins):
    OAS1    OASL    OAS2

    Find genes that share paralogs with OAS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OAS3 (see all 826)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs454968921,2
    C--110413379(+) CCTCT-/AC/C/T
            
    TCTGC
    1 -- int11NA 2
    rs1898867891,2
    --113374398(+) CCCTTA/CTTTTC 1 -- us2k10--------
    rs1817003921,2
    --113374408(+) CCTTCA/GATCCA 1 -- us2k10--------
    rs128331491,2
    H--113374453(+) ACTCTG/CCATAG 1 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs123026551,2
    C,F,A,H--113374506(+) ATCCAG/ATCTCA 1 -- us2k118Minor allele frequency- A:0.19NS EA NA CSA WA 2020
    rs1123575121,2
    F--113374511(+) GTCTCG/ATATCT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs128110301,2
    H--113374520(+) CTCTGA/GCAGGG 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs128160371,2
    H--113374534(+) TCAGAT/CTCCAG 1 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs128111871,2
    H--113374583(+) ATTAAA/GGTTTT 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs128091301,2
    H--113374584(+) TTAAAG/TTTTTT 1 -- us2k14Minor allele frequency- T:0.00NS EA 418

    HapMap Linkage Disequilibrium report for OAS3 (113376157 - 113411054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OAS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv515628CNV Loss19592680
    nsv832516CNV Gain17160897

    Human Gene Mutation Database (HGMD): OAS3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OAS3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603351    OMIM disorders: --

    3 diseases for OAS3:    
    About MalaCards
    chikungunya    west nile encephalitis    tick-borne encephalitis

    2 diseases from the University of Copenhagen DISEASES database for OAS3:
    West Nile encephalitis     tick-borne encephalitis

    Find genes that share disorders with OAS3           About GenesLikeMe

    Genetic Association Database (GAD): OAS3
    Human Genome Epidemiology (HuGE) Navigator: OAS3 (9 documents)

    Export disorders for OAS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OAS3 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with OAS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The large form of human 2',5'-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus. (PubMed id 19056102)1, 2, 9 Brehin A.C....Despres P. (Virology 2009)
    2. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PubMed id 19923450)1, 2, 9 Lin R.J.... Lin Y.L. (J. Immunol. 2009)
    3. Characterization of the gene encoding the 100-kDa form of human 2', 5'oligoadenylate synthetase. (PubMed id 11112351)1, 2, 9 Rebouillat D....Williams B.R. (Genomics 2000)
    4. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PubMed id 16014697)1, 4, 9 Tessier M.C....Polychronakos C. (J. Med. Genet. 2006)
    5. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PubMed id 21909109)1, 4 Kim Y.J....Cho Y.S. (Nat. Genet. 2011)
    6. Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (PubMed id 21270382)1, 4 Baik I....Shin C. (Am. J. Clin. Nutr. 2011)
    7. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    9. Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. (PubMed id 21050126)1, 4 Barkhash A.V....Brinton M.A. (J. Infect. Dis. 2010)
    10. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. (PubMed id 19667218)1, 4 Comabella M....Montalban X. (Arch. Neurol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4940 HGNC: 8088 AceView: OAS3 Ensembl:ENSG00000111331 euGenes: HUgn4940
    ECgene: OAS3 Kegg: 4940 H-InvDB: OAS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OAS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OAS3 gene:
    Search GeneIP for patents involving OAS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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