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Aliases for OAS3 Gene

Aliases for OAS3 Gene

  • 2'-5'-Oligoadenylate Synthetase 3, 100kDa 2
  • 2-5-Oligoadenylate Synthetase 3, 100kDa 2 3
  • (2-5)Oligo(A) Synthase 3 3 4
  • 2-5A Synthase 3 3 4
  • P100 OAS 3 4
  • P100OAS 3 4
  • 2-5-Oligoadenylate Synthetase 3 (100 KD) 2
  • 2-5oligoadenylate Synthetase P100 3
  • 2-5-Oligoadenylate Synthase 3 3
  • (2-5)Oligo(A) Synthetase 3 3
  • 2-5A Synthetase 3 3
  • EC 2.7.7.84 4
  • EC 2.7.7 64
  • P100 3

External Ids for OAS3 Gene

Summaries for OAS3 Gene

Entrez Gene Summary for OAS3 Gene

  • This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

GeneCards Summary for OAS3 Gene

OAS3 (2'-5'-Oligoadenylate Synthetase 3, 100kDa) is a Protein Coding gene. Diseases associated with OAS3 include chikungunya and west nile encephalitis. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include double-stranded RNA binding and 2-5-oligoadenylate synthetase activity. An important paralog of this gene is OAS2.

UniProtKB/Swiss-Prot for OAS3 Gene

  • Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).

Gene Wiki entry for OAS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAS3 Gene

Genomics for OAS3 Gene

Genomic Location for OAS3 Gene

Start:
112,938,352 bp from pter
End:
112,973,251 bp from pter
Size:
34,900 bases
Orientation:
Plus strand

Genomic View for OAS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OAS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAS3 Gene

Regulatory Elements for OAS3 Gene

Transcription factor binding sites by QIAGEN in the OAS3 gene promoter:

Proteins for OAS3 Gene

  • Protein details for OAS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6K5-OAS3_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase 3
    Protein Accession:
    Q9Y6K5
    Secondary Accessions:
    • Q2HJ14
    • Q9H3P5

    Protein attributes for OAS3 Gene

    Size:
    1087 amino acids
    Molecular mass:
    121170 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer
    SequenceCaution:
    • Sequence=AAD28543.1; Type=Frameshift; Positions=394, 398; Evidence={ECO:0000305};

neXtProt entry for OAS3 Gene

Proteomics data for OAS3 Gene at MOPED

Selected DME Specific Peptides for OAS3 Gene

Post-translational modifications for OAS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for OAS3 Gene

UniProtKB/Swiss-Prot:

OAS3_HUMAN
Family:
  • Belongs to the 2-5A synthase family.:
    • Q9Y6K5
genes like me logo Genes that share domains with OAS3: view

No data available for Gene Families for OAS3 Gene

Function for OAS3 Gene

Molecular function for OAS3 Gene

GENATLAS Biochemistry: 2,5-oligoadenylate synthetase 3,100kDa,ubiquitously expressed ,interferon induced
UniProtKB/Swiss-Prot CatalyticActivity: 3 ATP = pppA2p5A2p5A + 2 diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators
UniProtKB/Swiss-Prot Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
UniProtKB/Swiss-Prot Induction: By type I interferon (IFN) and viruses

Enzyme Numbers (IUBMB) for OAS3 Gene

Gene Ontology (GO) - Molecular Function for OAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 2-5-oligoadenylate synthetase activity IDA 9880533
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IDA 9880533
GO:0005515 protein binding IPI 21903422
GO:0005524 ATP binding IDA 9880533
genes like me logo Genes that share ontologies with OAS3: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OAS3 Gene

Localization for OAS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAS3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OAS3 Gene COMPARTMENTS Subcellular localization image for OAS3 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for OAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OAS3: view

Pathways for OAS3 Gene

genes like me logo Genes that share pathways with OAS3: view

Gene Ontology (GO) - Biological Process for OAS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 2440675
GO:0006955 immune response --
GO:0008152 metabolic process --
GO:0009615 response to virus IDA 19056102
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with OAS3: view

Compounds for OAS3 Gene

(1) HMDB Compounds for OAS3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for OAS3 Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 93.3 6
genes like me logo Genes that share compounds with OAS3: view

Transcripts for OAS3 Gene

Unigene Clusters for OAS3 Gene

2-5-oligoadenylate synthetase 3, 100kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OAS3 Gene

No ASD Table

Relevant External Links for OAS3 Gene

GeneLoc Exon Structure for
OAS3
ECgene alternative splicing isoforms for
OAS3

Expression for OAS3 Gene

mRNA expression in normal human tissues for OAS3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OAS3 Gene

SOURCE GeneReport for Unigene cluster for OAS3 Gene Hs.744211

mRNA Expression by UniProt/SwissProt for OAS3 Gene

Q9Y6K5-OAS3_HUMAN
Tissue specificity: Present at high level in placenta trophoblast
genes like me logo Genes that share expressions with OAS3: view

Orthologs for OAS3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OAS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAS3 36
  • 99.57 (n)
  • 99.36 (a)
OAS3 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OAS3 36
  • 82.8 (n)
  • 78.47 (a)
OAS3 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oas3 36
  • 75.89 (n)
  • 70.66 (a)
Oas3 16
Oas3 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OAS3 37
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oas3 36
  • 75.46 (n)
  • 70.02 (a)
Species with no ortholog for OAS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OAS3 Gene

ENSEMBL:
Gene Tree for OAS3 (if available)
TreeFam:
Gene Tree for OAS3 (if available)

Paralogs for OAS3 Gene

Paralogs for OAS3 Gene

Selected SIMAP similar genes for OAS3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OAS3: view

Variants for OAS3 Gene

Sequence variations from dbSNP and Humsavar for OAS3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7023 -- 112,973,170(-) ggaga(G/T)aatgg utr-variant-3-prime
rs11822 -- 112,972,484(-) TGTGG(A/G/T)TGTTT utr-variant-3-prime
rs739903 -- 112,971,069(-) TAGTG(C/T)GGACA utr-variant-3-prime
rs757403 -- 112,969,774(-) CCTTT(A/G)GCACC intron-variant
rs757404 -- 112,969,387(-) ATCAA(C/T)CACGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OAS3 Gene

Variant ID Type Subtype PubMed ID
nsv832516 CNV Gain 17160897
nsv515628 CNV Loss 19592680

Relevant External Links for OAS3 Gene

HapMap Linkage Disequilibrium report
OAS3
Human Gene Mutation Database (HGMD)
OAS3

Disorders for OAS3 Gene

(2) University of Copenhagen DISEASES for OAS3 Gene

Relevant External Links for OAS3

Genetic Association Database (GAD)
OAS3
Human Genome Epidemiology (HuGE) Navigator
OAS3
genes like me logo Genes that share disorders with OAS3: view

No data available for UniProtKB/Swiss-Prot for OAS3 Gene

Publications for OAS3 Gene

  1. Characterization of the gene encoding the 100-kDa form of human 2', 5'oligoadenylate synthetase. (PMID: 11112351) Rebouillat D. … Williams B.R. (Genomics 2000) 3 4 23
  2. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PMID: 16014697) Tessier M.C. … Polychronakos C. (J. Med. Genet. 2006) 3 23 49
  3. The large form of human 2',5'-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus. (PMID: 19056102) Brehin A.C. … Despres P. (Virology 2009) 3 4 23
  4. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PMID: 19923450) Lin R.J. … Lin Y.L. (J. Immunol. 2009) 3 4 23
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4

Products for OAS3 Gene

Sources for OAS3 Gene

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