Aliases for OAS3 Gene
External Ids for OAS3 Gene
Previous GeneCards Identifiers for OAS3 Gene
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]
GeneCards Summary for OAS3 Gene
OAS3 (2'-5'-Oligoadenylate Synthetase 3) is a Protein Coding gene. Diseases associated with OAS3 include Chikungunya and West Nile Encephalitis. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include RNA binding and transferase activity. An important paralog of this gene is OAS2.
UniProtKB/Swiss-Prot for OAS3 Gene
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).