 |
 | Services
| |
 |
Aliases & Descriptions for OAS3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.7.7.- 3 | | MGC133260 2 | | p100 2 | | p100OAS 3 |
| | | Descriptions |
|---|
| (2-5')oligo(A) synthetase 3 3 | | 2'-5'-oligoadenylate synthetase 3 (100 kD) 1, 2 | | 2'-5'-oligoadenylate synthetase 3, 100kDa 2 | | 2'-5'oligoadenylate synthetase 3 2 | | 2'-5'oligoadenylate synthetase p100 2 | | 2-5A synthetase 3 3 | | p100 OAS 3 |
|
| | Search outside databases for aliases for OAS3 genePrevious GC identifers: GC12P112271 GC12P112895 GC12P113159 GC12P111788 |
Summaries for OAS3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for OAS3: This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq] UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5Function: May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrateGene Wiki entry for OAS3 |
Genomic Location for OAS3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OAS3 gene 
Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.13 HGNC cytogenetic band: 12q24.2OAS3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P111838:
(about GC identifiers)
Start:
|
111,860,540 bp from pter |
End:
|
111,900,791 bp from pter |
Size:
|
40,252 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009775.16
| Proteins for OAS3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5 (See
protein sequence)Recommended Name: 2'-5'-oligoadenylate synthetase 3 Size: 1087 amino acids; 121165 Da
Subunit: Monomer
Secondary accessions: Q9H3P5Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006178.2
ENSEMBL proteins: ENSP00000228928
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for OAS3: Assays for OAS3: | Protein
Domains/ Families for OAS3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y6K5
ProtoNet protein and cluster: Q9Y6K5 2 Blocks protein families: IPB002934 DNA polymerase IPB006117 2-5-oligoadenylate synthetase
UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5Similarity: Belongs to the 2-5A synthetase family | Gene Function for OAS3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006187
Applied Biosystems Silencer® siRNAs for OAS3
Sigma-Aldrich siRNA for OAS3  Sigma-Aldrich shRNA for OAS3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006187                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006187                                  untagged cDNA clone in CMV expression vector: NM_006187 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006187
UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5Function: May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrateCatalytic activity: Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAsInduction: By interferonsEnzyme Number (IUBMB): EC 2.7.7.- Genatlas biochemistry entry for OAS3:2',5'-oligoadenylate synthetase 3,100kDa,ubiquitously expressed ,interferon induced4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for OAS3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for OAS3 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for OAS3 (ENSP000002289283) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
TAS | 2440675 | | GO:0006955 | immune response |
IEA | -- | About this table
|
Drugs & Compounds for OAS3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for OAS3
|
Transcripts for OAS3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006187
Sigma-Aldrich siRNA for OAS3  Sigma-Aldrich shRNA for OAS3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006187 REFSEQ mRNAs for OAS3 gene: NM_006187.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006187               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006187                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006187                                  untagged cDNA clone in CMV expression vector: NM_006187  Additional cDNA sequence: AB044545.1 AF063613.1 AK000608.1 AK292949.1 BC012015.1 BC113746.1 CR602049.1 10 DOTS entries: DT.211616 DT.436928 DT.95335870 DT.100792978 DT.121211619 DT.100721041 DT.40275249 DT.87016758 DT.91679771 DT.91872112 24/277 AceView cDNA sequences (see all 277
):AK000608 BM842879 BU169707 BM808561 AA836757 BM471312 BG390192 BM810143 BU539874 NM_006187 AI650519 BM760794 BQ279127 CB109077 BU944625 CB123126 BU145349 BU539624 CA455330 AA312111 CA455349 BM913534 BM977099 BU956885
highest scoring ESTs for OAS3:AA135525 AA015623 AA015624 AA021105 AA021603 AA055014 AA102408 AA125906 AA127075 AA127938 Unigene Cluster for OAS3: 2'-5'-oligoadenylate synthetase 3, 100kDa Hs.528634 [show with all ESTs]Unigene Representative Sequence: AB044545
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000228928
|
Expression for OAS3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OAS3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OAS3
1 / 2 / 3 5 probe-sets matching OAS3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCGCTGGTAC
SOURCE GeneReport for Unigene cluster: Hs.528634 UniProtKB/Swiss-Prot: OAS3_HUMAN, Q9Y6K5Tissue specificity: Present at high level in placenta trophoblast |
Orthologs for OAS3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OAS3 gene from 3 species
About this table Species with no ortholog for OAS3
ENSEMBL Gene Tree for OAS3 | Paralogs for OAS3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OAS3 gene
- OAS22 OASL2 OAS12
|
SNPs/Variants for OAS3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OAS3 (up to first 250kb)
|
Disorders & Mutations for OAS3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603351
Genetic Association Database: OAS3 Human Genome Epidemiology Navigator: OAS3 (2 documents)
|
Medical News for OAS3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OAS3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/25 PubMed articles for OAS3 gene (see all 25
):- Characterization of the gene encoding the 100-kDa form of human 2', 5'oligoadenylate synthetase. (PubMed id 11112351)1, 3, 4 Rebouillat D....Williams B.R. (2000)
- Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PubMed id 16014697)1, 3, 6 Tessier M.C....Polychronakos C. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)3, 4 Scherer S.E.... Gibbs R.A. (2006)
- Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)3, 6 King J.K....Chen P.J. (2002)
- Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PubMed id 11280764)3, 4 Ito M....Itoh K. (2001)
- The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains. (PubMed id 9880533)3, 4 Rebouillat D.... Hovanessian A.G. (1999)
- The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. (PubMed id 9790745)2, 3 Hovnanian A....Hovanessian A.G. (1998)
- The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation. (PubMed id 17408844)3 Hovanessian A.G. and Justesen J. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- 69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters. (PubMed id 9346316)3 Marie I....Hovanessian A.G. (1997)
|
Search for OAS3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OAS3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OAS3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OAS3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for OAS3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OAS3:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (OAS3) | | Antibodies (OAS3) |
| | | Search Tocris compounds for OAS3 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|