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Aliases for OAS2 Gene

Aliases for OAS2 Gene

  • 2'-5'-Oligoadenylate Synthetase 2, 69/71kDa 2
  • 2-5-Oligoadenylate Synthetase 2, 69/71kDa 2 3
  • 2-5-Oligoadenylate Synthetase 2 (69-71 KD) 2
  • (2-5)Oligo(A) Synthase 2 4
  • P69 OAS / P71 OAS 4
  • P69OAS / P71OAS 4
  • 2-5A Synthase 2 4
  • EC 2.7.7.84 4
  • EC 2.7.7 63

External Ids for OAS2 Gene

Previous GeneCards Identifiers for OAS2 Gene

  • GC12P112311
  • GC12P112935
  • GC12P113199
  • GC12P111828
  • GC12P111879
  • GC12P113416
  • GC12P110428

Summaries for OAS2 Gene

Entrez Gene Summary for OAS2 Gene

  • This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for OAS2 Gene

OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa) is a Protein Coding gene. Diseases associated with OAS2 include tick-borne encephalitis and west nile encephalitis. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include double-stranded RNA binding and 2-5-oligoadenylate synthetase activity. An important paralog of this gene is OAS1.

UniProtKB/Swiss-Prot for OAS2 Gene

  • Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.

Gene Wiki entry for OAS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAS2 Gene

Genomics for OAS2 Gene

Regulatory Elements for OAS2 Gene

Transcription factor binding sites by QIAGEN in the OAS2 gene promoter:

Genomic Location for OAS2 Gene

Start:
112,978,395 bp from pter
End:
113,011,723 bp from pter
Size:
33,329 bases
Orientation:
Plus strand

Genomic View for OAS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAS2 Gene

Proteins for OAS2 Gene

  • Protein details for OAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29728-OAS2_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase 2
    Protein Accession:
    P29728
    Secondary Accessions:
    • A8K9T1
    • Q6PJ33
    • Q86XX8

    Protein attributes for OAS2 Gene

    Size:
    719 amino acids
    Molecular mass:
    82431 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for OAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAS2 Gene

Proteomics data for OAS2 Gene at MOPED

Selected DME Specific Peptides for OAS2 Gene

Post-translational modifications for OAS2 Gene

Other Protein References for OAS2 Gene

Domains for OAS2 Gene

Suggested Antigen Peptide Sequences for OAS2 Gene

Graphical View of Domain Structure for InterPro Entry

P29728

UniProtKB/Swiss-Prot:

OAS2_HUMAN :
  • P29728
Family:
  • Belongs to the 2-5A synthase family.
genes like me logo Genes that share domains with OAS2: view

No data available for Gene Families for OAS2 Gene

Function for OAS2 Gene

Molecular function for OAS2 Gene

GENATLAS Biochemistry: 2,5-oligoadenylate synthetase 2,with two alternatively spliced isoforms 69kDa,71kDa,interferon induced
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2.1 mM for ATP {ECO:0000269 PubMed:10464285, ECO:0000269 PubMed:11986302, ECO:0000269 PubMed:9880569};
UniProtKB/Swiss-Prot CatalyticActivity: 3 ATP = pppA2p5A2p5A + 2 diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators.
UniProtKB/Swiss-Prot Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
UniProtKB/Swiss-Prot Induction: By type I interferon (IFN) and viruses

Enzyme Numbers (IUBMB) for OAS2 Gene

Gene Ontology (GO) - Molecular Function for OAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 2-5-oligoadenylate synthetase activity IMP 10464285
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IMP 10464285
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IMP 10464285
genes like me logo Genes that share ontologies with OAS2: view

miRNA for OAS2 Gene

miRTarBase miRNAs that target OAS2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OAS2 Gene

Localization for OAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAS2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OAS2 Gene COMPARTMENTS Subcellular localization image for OAS2 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for OAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 19923450
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with OAS2: view

Pathways for OAS2 Gene

genes like me logo Genes that share pathways with OAS2: view

Gene Ontology (GO) - Biological Process for OAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 2440675
GO:0006164 purine nucleotide biosynthetic process IDA 11682059
GO:0006401 RNA catabolic process IEA --
GO:0006486 protein glycosylation IDA 9880569
GO:0006955 immune response --
genes like me logo Genes that share ontologies with OAS2: view

Compounds for OAS2 Gene

(1) Novoseek inferred chemical compound relationships for OAS2 Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 93 3
genes like me logo Genes that share compounds with OAS2: view

Transcripts for OAS2 Gene

Unigene Clusters for OAS2 Gene

2-5-oligoadenylate synthetase 2, 69/71kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OAS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
SP1:
SP2: -
SP3: -
SP4:
SP5: - - -
SP6:
SP7:
SP8:

Relevant External Links for OAS2 Gene

GeneLoc Exon Structure for
OAS2
ECgene alternative splicing isoforms for
OAS2

Expression for OAS2 Gene

mRNA expression in normal human tissues for OAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OAS2 Gene

SOURCE GeneReport for Unigene cluster for OAS2 Gene Hs.414332

genes like me logo Genes that share expressions with OAS2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OAS2 Gene

Orthologs for OAS2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAS2 35
  • 99.35 (n)
  • 99.03 (a)
OAS2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OAS2 35
  • 78.37 (n)
  • 68.55 (a)
OAS2 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OAS2 35
  • 79.05 (n)
  • 70.78 (a)
OAS2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oas2 35
  • 71.83 (n)
  • 64.16 (a)
Oas2 16
Oas2 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OAS2 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oas2 35
  • 70.24 (n)
  • 61.3 (a)
Species with no ortholog for OAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OAS2 Gene

ENSEMBL:
Gene Tree for OAS2 (if available)
TreeFam:
Gene Tree for OAS2 (if available)

Paralogs for OAS2 Gene

Paralogs for OAS2 Gene

Selected SIMAP similar genes for OAS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with OAS2: view

Variants for OAS2 Gene

Sequence variations from dbSNP and Humsavar for OAS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13311 -- 113,010,847(+) GTGAT(A/C)TTGCT downstream-variant-500B, utr-variant-3-prime
rs15895 -- 113,010,483(-) ATCTC(C/T)AGAAG utr-variant-3-prime, reference, stop-lost
rs739901 -- 112,977,858(+) AGAAG(A/C)AGACC upstream-variant-2KB
rs739902 -- 112,977,857(+) CAGAA(A/G)CAGAC upstream-variant-2KB
rs757401 -- 112,991,663(-) aaatg(C/T)gtatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OAS2 Gene

Variant ID Type Subtype PubMed ID
nsv832516 CNV Gain 17160897
nsv890 CNV Insertion 18451855
nsv507676 CNV Insertion 20534489

Relevant External Links for OAS2 Gene

HapMap Linkage Disequilibrium report
OAS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAS2 Gene

Disorders for OAS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for OAS2 Gene including...

Search for OAS2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for OAS2 Gene

Relevant External Links for OAS2

Genetic Association Database (GAD)
OAS2
Human Genome Epidemiology (HuGE) Navigator
OAS2
genes like me logo Genes that share disorders with OAS2: view

No data available for UniProtKB/Swiss-Prot for OAS2 Gene

Publications for OAS2 Gene

  1. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PMID: 16014697) Tessier M.C. … Polychronakos C. (J. Med. Genet. 2006) 3 23 48
  2. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PMID: 19923450) Lin R.J. … Lin Y.L. (J. Immunol. 2009) 3 4 23
  3. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains. (PMID: 1577824) Marie I. … Hovanessian A.G. (J. Biol. Chem. 1992) 3 4
  4. Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon. (PMID: 2211721) Marie I. … Hovanessian A.G. (J. Biol. Chem. 1990) 3 4
  5. The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. (PMID: 9790745) Hovnanian A. … Hovanessian A.G. (Genomics 1998) 2 3

Products for OAS2 Gene

Sources for OAS2 Gene

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