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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OAS2 Gene

protein-coding   GIFtS: 61
GCID: GC12P113416

2'-5'-oligoadenylate synthetase 2, 69/71kDa

(Previous name: 2'-5'-oligoadenylate synthetase 2 (69-71 kD) )
 Explore 12 diseases affiliated with
OAS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OAS2    

Aliases
for OAS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
2'-5'-Oligoadenylate Synthetase 2, 69/71kDa1 2     2'-5'-Oligoadenylate Synthase 22
2-5A Synthase 22 3     (2-5')Oligo(A) Synthase 23
P69 OAS / P71 OAS2 3     EC 2.7.7.-3
2'-5'-Oligoadenylate Synthetase 2 (69-71 KD)1     P69OAS / P71OAS3
(2'-5')Oligo(A) Synthetase 22     EC 2.7.78

External Ids:    HGNC: 80871   Entrez Gene: 49392   Ensembl: ENSG000001113357   OMIM: 6033505   UniProtKB: P297283   

Export aliases for OAS2 gene to outside databases

Previous GC identifers: GC12P112311 GC12P112935 GC12P113199 GC12P111828 GC12P111879 GC12P110428


Summaries
for OAS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OAS2:
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to
viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific
nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L,
which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene
family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different
isoforms have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral
response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth,
differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then
bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation.
Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein
synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent
pathway or an alternative antiviral pathway independent of RNase L

Gene Wiki entry for OAS2


Genomic Views
for OAS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OAS2 gene promoter:
         Elk-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OAS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OAS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.2

OAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAS2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113416:  view genomic region     (about GC identifiers)

Start:
 113,416,200 bp from pter      End:
 113,449,528 bp from pter
Size:
 33,329 bases      Orientation:
 plus strand

Proteins
for OAS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728 (See protein sequence)
Recommended Name: 2'-5'-oligoadenylate synthase 2  
Size: 719 amino acids; 82431 Da
Cofactor: Magnesium (Potential)
Subunit: Homodimer
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic
reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth
microsomal fractions
Secondary accessions: A8K9T1 Q6PJ33 Q86XX8
Alternative splicing: 3 isoforms:  P29728-1   P29728-2   P29728-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OAS2: NX_P29728

Post-translational modifications:

  • Myristoylation is not essential for its activity1
  • Glycosylated. Glycosylation is essential for its activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P29728

    • 2 DME Specific Peptides for OAS2 (P29728)
     GEFSTCFT  SDADLVVF 

    OAS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001027903.1  NP_002526.2  NP_058197.2  

    ENSEMBL proteins: 
     ENSP00000342278   ENSP00000376362   ENSP00000411763   ENSP00000446977   ENSP00000450307  
    Reactome Protein details: P29728
    Human Recombinant Protein Products: 
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    Novus Biologicals OAS2 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for OAS2

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA19923450
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005792microsome ----


    OAS2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for OAS2

    Protein Domains /
    Families
    for OAS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OAS2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002934 Nucleotidyltransferase
     IPR018952 2-5-oligoAdlate_synth_1_dom2/C
     IPR006117 2-5-oligoadenylate_synth_CS
     IPR006116 2-5-oligoadenylate_synth_N
     IPR026774 2-5A_synthase

    Graphical View of Domain Structure for InterPro Entry P29728

    ProtoNet protein and cluster: P29728

    2 Blocks protein families:
    IPB002934 DNA polymerase
    IPB006117 2-5-oligoadenylate synthetase


    UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728
    Similarity: Belongs to the 2-5A synthase family


    Function
    for OAS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728
    Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral
    response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth,
    differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then
    bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation.
    Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein
    synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent
    pathway or an alternative antiviral pathway independent of RNase L
    Catalytic activity: Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the
    latent RNase L that, when activated, cleaves single-stranded RNAs
    Enzyme regulation: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral
    infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is
    tolerated. ssRNA or dsDNA do not act as activators
    Biophysicochemical properties: Kinetic parameters: KM=2.1 mM for ATP;
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for OAS2:
    2',5'-oligoadenylate synthetase 2,with two alternatively spliced isoforms 69kDa,71kDa,interferon induced

    Enzyme Numbers (IUBMB): EC 2.7.7.-1 EC 2.7.72

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: OAS2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00017302'-5'-oligoadenylate synthetase activity IMP10464285
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IMP10464285
    GO:0005524ATP binding IMP10464285
    GO:0008270zinc ion binding IDA11682059


    OAS2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for OAS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61
    2Interferon gamma signaling
    		Interferon gamma signaling1.00
    		Expression of IFNG-stimulated genes0.72
    3Measles
    		Measles1.00
    		Influenza A0.35
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    5Immune System
    		Immune System1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/7        Reactome Pathways for OAS2 (see all 7)
        Interferon alpha/beta signaling
    Interferon gamma signaling
    Cytokine Signaling in Immune system
    Expression of IFN-induced genes
    Expression of IFNG-stimulated genes


    3         Kegg Pathways  (Kegg details for OAS2):
        Hepatitis C
    Measles
    Influenza A


    OAS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OAS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for OAS2 (P297283 ENSP000003422784) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOD2Q9HC293I2D: score=1 
    ADARENSP000003574594STRING: ENSP00000357459
    B2MENSP000003408584STRING: ENSP00000340858
    CIITAENSP000003163284STRING: ENSP00000316328
    ENSG00000235657ENSP000003885264STRING: ENSP00000388526
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS2440675
    GO:0006164purine nucleotide biosynthetic process IDA11682059
    GO:0006401RNA catabolic process IEA--
    GO:0006486protein glycosylation IDA9880569
    GO:0006955immune response ----


    OAS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OAS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OAS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OAS2
    1 Novoseek chemical compound relationship for OAS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 93 4 16014697 (1), 14728690 (1), 15749911 (1)

    Search CenterWatch for drugs/clinical trials and news about OAS2 

    Transcripts
    for OAS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OAS2 gene (3 alternative transcripts): 
    NM_001032731.1  NM_002535.2  NM_016817.2  

    Unigene Cluster for OAS2:

    2'-5'-oligoadenylate synthetase 2, 69/71kDa
    Hs.414332  [show with all ESTs]
    Unigene Representative Sequence: NM_002535
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342315(uc001tuj.3) ENST00000392583(uc001tui.1) ENST00000449768(uc001tuh.3)
    ENST00000552756 ENST00000551603 ENST00000548941

    miRNA
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    hsa-miR-31 hsa-miR-644 hsa-miR-515-5p hsa-miR-182 hsa-miR-198 hsa-miR-1252 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmid: OAS2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF074990.1 AK292796.1 AK292906.1 BC010625.1 BC023637.2 BC049215.1 BC053870.1 BC069052.1 
    M87284.1 M87434.1 

    7 DOTS entries:

    DT.404686  DT.75168849  DT.100691521  DT.100785794  DT.121200003  DT.121200004  DT.100763558 

    24/184 AceView cDNA sequences (see all 184):

    CF137864 CR623050 AW835144 BQ007650 BM909558 CR592869 BC049215 BM927515 
    BM471377 AW835147 BE882346 BC023637 AA040536 AA040537 BX444261 BQ643017 
    AW835142 BM927608 AW835145 AW168226 AW835148 BE043940 BQ063465 BG292035 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for OAS2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                                                                                                                                    
    SP2:                                -                                                                                                   
    SP3:                                -                                                                                                   
    SP4:                                                                                                                                    
    SP5:                    -     -     -                                                                                                   


    ECgene alternative splicing isoforms for OAS2

    Expression
    for OAS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OAS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAGAGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OAS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OAS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OAS2

    SOURCE GeneReport for Unigene cluster: Hs.414332
        SABiosciences Expression via Pathway-Focused PCR Arrays including OAS2: 
              Antiviral Response in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for OAS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for OAS2 (if available)
    TreeFam Gene Tree for OAS2 (if available) 

    Paralogs
    for OAS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OAS2 gene
    OASL2  OAS12  OAS32  
    2 SIMAP similar genes for OAS2 using alignment to 4 protein entries:     OAS2_HUMAN (see all proteins):
    OAS3    OAS1

    OAS2 for paralogs           About GeneDecksing



    Genomic Variants
    for OAS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/628 NCBI SNPs in OAS2 are shown (see all 628)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1899839661,2
    		--113414399(+) AATTTA/TAAAAA 3 -- us2k10--------
    rs1498196361,2
    		--113414805(+) ATCACA/GGGCAA 3 -- us2k10--------
    rs1139785771,2
    		--113414813(+) CAAATG/ATTTCC 3 -- us2k12Minor allele frequency- A:0.02CSA WA 119
    rs1816445091,2
    		--113414820(+) TTCCAC/TCTTTG 3 -- us2k10--------
    rs1871585791,2
    		--113414904(+) GCAGTA/CAAAGT 3 -- us2k10--------
    rs1903435541,2
    		--113415022(+) GCTCAC/TGTGAT 3 -- us2k10--------
    rs2019139471,2
    		C--113415076(-) GGGTCC/TCCCAC 3 -- us2k10--------
    rs1479389741,2
    		--113415164(+) AGTCTA/GTTAAG 3 -- us2k10--------
    rs355538231,2
    		C,F,--113415299(+) ATAATG/TTTTGA 3 -- us2k16Minor allele frequency- T:0.19NA WA EA 364
    rs1146702051,2
    		F,--113415384(+) CCCCCA/GCTACA 3 -- us2k11Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for OAS2 (113416200 - 113449528 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OAS2: --
    Human Gene Mutation Database (HGMD): OAS2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OAS2
    DNA2.0 Custom Variant and Variant Library Synthesis for OAS2

    Disorders / Diseases
    for OAS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OAS2 for disorders           About GeneDecksing

    OMIM gene information: 603350    OMIM disorders: --

    12 diseases for OAS2:    About MalaCards
    tick-borne encephalitis    west nile encephalitis    eczema herpeticum    dengue hemorrhagic fever
    hemorrhagic fever    encephalitis    eczema    hepatitis c
    hepatitis b    measles    hepatitis    influenza

    3 diseases from the University of Copenhagen DISEASES database for OAS2:
    West Nile encephalitis     tick-borne encephalitis     Eczema herpeticum
    Genetic Association Database (GAD): OAS2
    Human Genome Epidemiology (HuGE) Navigator: OAS2 (6 documents)

    Export disorders for OAS2 gene to outside databases

    Publications
    for OAS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OAS2 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with OAS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct antiviral roles for human 2',5'-oligoadenyla te synthetase family members against dengue virus infection. (PubMed id 19923450)1, 2, 9 Lin R.J....Lin Y.L. (2009)
    2. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PubMed id 16014697)1, 4, 9 Tessier M.C....Polychronakos C. (2006)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)1, 4 King J.K....Chen P.J. (2002)
    6. Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase. (PubMed id 9880569)1, 2 Sarkar S.N.... Sen G.C. (1999)
    7. The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases. (PubMed id 10464285)1, 2 Sarkar S.N.... Sen G.C. (1999)
    8. The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. (PubMed id 9790745)1, 3 Hovnanian A....Hovanessian A.G. (1998)
    9. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains. (PubMed id 1577824)1, 2 Marie I. and Hovanessian A.G. (1992)
    10. Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon. (PubMed id 2211721)1, 2 Marie I.... Hovanessian A.G. (1990)

    External Searches for OAS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing OAS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4939 HGNC: 8087 AceView: OAS2 Ensembl:ENSG00000111335 euGenes: HUgn4939
    ECgene: OAS2 Kegg: 4939 H-InvDB: OAS2

    Other Databases showing OAS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OAS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OAS2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for OAS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OAS2 gene:
    Search GeneIP for patents involving OAS2

    GeneCards and IP:
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