Aliases for OAS2 Gene
External Ids for OAS2 Gene
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for OAS2 Gene
OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa) is a Protein Coding gene. Diseases associated with OAS2 include west nile encephalitis and tick-borne encephalitis. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include double-stranded RNA binding and 2-5-oligoadenylate synthetase activity. An important paralog of this gene is OAS1.
UniProtKB/Swiss-Prot for OAS2 Gene
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.