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OAS2 Gene

protein-coding   GIFtS: 64
GCID: GC12P113416

2'-5'-Oligoadenylate Synthetase 2, 69/71kDa

(Previous name: 2'-5'-oligoadenylate synthetase 2 (69-71 kD))
  See OAS2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
2'-5'-Oligoadenylate Synthetase 2, 69/71kDa1 2     2'-5'-Oligoadenylate Synthase 22
2-5A Synthase 22 3     (2-5')Oligo(A) Synthase 23
P69 OAS / P71 OAS2 3     EC 2.7.7.843
2'-5'-Oligoadenylate Synthetase 2 (69-71 KD)1     P69OAS / P71OAS3
(2'-5')Oligo(A) Synthetase 22     EC 2.7.78

External Ids:    HGNC: 80871   Entrez Gene: 49392   Ensembl: ENSG000001113357   OMIM: 6033505   UniProtKB: P297283   

Export aliases for OAS2 gene to outside databases

Previous GC identifers: GC12P112311 GC12P112935 GC12P113199 GC12P111828 GC12P111879 GC12P110428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OAS2 Gene:
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune
response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in
2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate
latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known
members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants
encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for OAS2 Gene:
OAS2 (2'-5'-oligoadenylate synthetase 2, 69/71kDa) is a protein-coding gene. Diseases associated with OAS2 include west nile encephalitis, and tick-borne encephalitis. GO annotations related to this gene include double-stranded RNA binding and 2'-5'-oligoadenylate synthetase activity. An important paralog of this gene is OASL.

UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate
antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell
growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from
ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and
subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in
the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the
classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L

Gene Wiki entry for OAS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OAS2 gene promoter:
         Elk-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOAS2 promoter sequence
   Search Chromatin IP Primers for OAS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.2

OAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAS2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113416:  view genomic region     (about GC identifiers)

Start:
113,416,200 bp from pter      End:
113,449,528 bp from pter
Size:
33,329 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728 (See protein sequence)
Recommended Name: 2'-5'-oligoadenylate synthase 2  
Size: 719 amino acids; 82431 Da
Cofactor: Magnesium (Potential)
Subunit: Homodimer
Secondary accessions: A8K9T1 Q6PJ33 Q86XX8
Alternative splicing: 3 isoforms:  P29728-1   P29728-2   P29728-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OAS2: NX_P29728

Explore proteomics data for OAS2 at MOPED

Post-translational modifications: 

  • Myristoylation is not essential for its activity1
  • Glycosylated. Glycosylation is essential for its activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for OAS2 (P29728)
     GEFSTCFT  SDADLVVF 


    See OAS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001027903.1  NP_002526.2  NP_058197.2  

    ENSEMBL proteins: 
     ENSP00000342278   ENSP00000376362   ENSP00000411763   ENSP00000446977   ENSP00000450307  
    Reactome Protein details: P29728

    OAS2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OAS2

     
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    antibodies-online proteins for OAS2 (2 products) 

     
    antibodies-online peptides for OAS2

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    antibodies-online antibodies for OAS2 (29 products) 

    OAS2 Assay Products:

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    Cloud-Clone Corp. ELISAs for OAS2
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    antibodies-online kits for OAS2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR002934 Nucleotidyltransferase
     IPR018952 2-5-oligoAdlate_synth_1_dom2/C
     IPR006117 2-5-oligoadenylate_synth_CS
     IPR006116 2-5-oligoadenylate_synth_N
     IPR026774 2-5A_synthase

    Graphical View of Domain Structure for InterPro Entry P29728

    ProtoNet protein and cluster: P29728

    2 Blocks protein domains:
    IPB002934 DNA polymerase
    IPB006117 2-5-oligoadenylate synthetase


    UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728
    Similarity: Belongs to the 2-5A synthase family


    Find genes that share domains with OAS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OAS2_HUMAN, P29728
    Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate
    antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell
    growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from
    ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and
    subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in
    the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the
    classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L
    Catalytic activity: 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate
    Enzyme regulation: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral
    infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group
    is tolerated. ssRNA or dsDNA do not act as activators
    Biophysicochemical properties: Kinetic parameters: KM=2.1 mM for ATP;
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for OAS2:
    2',5'-oligoadenylate synthetase 2,with two alternatively spliced isoforms 69kDa,71kDa,interferon induced

         Enzyme Numbers (IUBMB): EC 2.7.7.841 EC 2.7.72

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00017302'-5'-oligoadenylate synthetase activity IMP10464285
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IMP10464285
    GO:0005524ATP binding IMP10464285
    GO:0008270zinc ion binding IDA11682059
         
    Find genes that share ontologies with OAS2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OAS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target OAS2:
    hsa-mir-132-3p (MIRT021817), hsa-mir-335-5p (MIRT019125), hsa-mir-7-5p (MIRT025932)

    Block miRNA regulation of human, mouse, rat OAS2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate OAS2:
    hsa-miR-31 hsa-miR-644 hsa-miR-515-5p hsa-miR-182 hsa-miR-198 hsa-miR-1252 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidOAS2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for OAS2
    Predesigned siRNA for gene silencing in human, mouse, rat OAS2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): OAS2 (NM_016817)
    Sino Biological Human cDNA Clone for OAS2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OAS2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OAS2_HUMAN, P29728: Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic
    reticulum. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth
    microsomal fractions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA19923450
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with OAS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OAS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    3Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43
    4Hepatitis C
    Hepatitis C


    Find genes that share SuperPaths with OAS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for OAS2
        Interferon alpha/beta signaling
    Interferon gamma signaling


    4 Kegg Pathways  (Kegg details for OAS2):
        Hepatitis C
    Measles
    Influenza A
    Herpes simplex infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OAS2: 
              Antiviral Response in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OAS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OAS2 (P297283 ENSP000003422784) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOD2Q9HC293I2D: score=1 
    ADARENSP000003574594STRING: ENSP00000357459
    B2MENSP000003408584STRING: ENSP00000340858
    CIITAENSP000003163284STRING: ENSP00000316328
    ENSG00000235657ENSP000003885264STRING: ENSP00000388526
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS2440675
    GO:0006164purine nucleotide biosynthetic process IDA11682059
    GO:0006401RNA catabolic process IEA--
    GO:0006486protein glycosylation IDA9880569
    GO:0006955immune response ----

    Find genes that share ontologies with OAS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OAS2

    1 Novoseek inferred chemical compound relationship for OAS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 93 4 16014697 (1), 14728690 (1), 15749911 (1)



    Find genes that share compounds with OAS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OAS2 gene (3 alternative transcripts): 
    NM_001032731.1  NM_002535.2  NM_016817.2  

    Unigene Cluster for OAS2:

    2'-5'-oligoadenylate synthetase 2, 69/71kDa
    Hs.414332  [show with all ESTs]
    Unigene Representative Sequence: NM_002535
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342315(uc001tuj.3) ENST00000392583(uc001tui.1) ENST00000449768(uc001tuh.3)
    ENST00000552756 ENST00000551603 ENST00000548941
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate OAS2:
    hsa-miR-31 hsa-miR-644 hsa-miR-515-5p hsa-miR-182 hsa-miR-198 hsa-miR-1252 hsa-miR-519e*
    SwitchGear 3'UTR luciferase reporter plasmidOAS2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat OAS2

    Additional mRNA sequence: 

    AF074990.1 AK292796.1 AK292906.1 BC010625.1 BC023637.2 BC049215.1 BC053870.1 BC069052.1 
    M87284.1 M87434.1 

    7 DOTS entries:

    DT.404686  DT.75168849  DT.100691521  DT.100785794  DT.121200003  DT.121200004  DT.100763558 

    Selected AceView cDNA sequences (see all 184):

    BM909558 AW835142 AW835147 AW835148 BX444261 CR623050 BE882346 BC049215 
    BM927608 AA040537 AA040536 BE043940 BM471377 CR592869 BM927515 CF137864 
    BQ063465 BG292035 AW168226 AW835145 BQ007650 BC023637 BQ643017 AW835144 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OAS2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                                                                                                                                    
    SP2:                                -                                                                                                   
    SP3:                                -                                                                                                   
    SP4:                                                                                                                                    
    SP5:                    -     -     -                                                                                                   


    ECgene alternative splicing isoforms for OAS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OAS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGAGAAA
    OAS2 Expression
    About this image


    OAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Endothelial-like cells
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    OAS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OAS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414332
        Pathway & Disease-focused RT2 Profiler PCR Arrays including OAS2: 
              Antiviral Response in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for OAS2
    OriGene qSTAR qPCR primer pairs in human, mouse for OAS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OAS2
    QuantiTect SYBR Green Assays in human, mouse, rat OAS2
    QuantiFast Probe-based Assays in human, mouse, rat OAS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OAS2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oas21 , 5 2'-5' oligoadenylate synthetase 21, 5 71.83(n)1
    64.16(a)1
      5 (60.64 cM)5
    2467281  NM_145227.31  NP_660262.21 
     1207303335 


    ENSEMBL Gene Tree for OAS2 (if available)
    TreeFam Gene Tree for OAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OAS2 gene
    OASL2  OAS12  OAS32  
    2 SIMAP similar genes for OAS2 using alignment to 4 protein entries:     OAS2_HUMAN (see all proteins):
    OAS3    OAS1

    Find genes that share paralogs with OAS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OAS2 (see all 753)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899839661,2
    --113209970(+) AATTTA/TAAAAA 3 -- us2k10--------
    rs1498196361,2
    --113210376(+) ATCACA/GGGCAA 3 -- us2k10--------
    rs1139785771,2
    F--113210384(+) CAAATG/ATTTCC 3 -- us2k12Minor allele frequency- A:0.02CSA WA 119
    rs1816445091,2
    --113210391(+) TTCCAC/TCTTTG 3 -- us2k10--------
    rs1871585791,2
    --113210475(+) GCAGTA/CAAAGT 3 -- us2k10--------
    rs1903435541,2
    --113210593(+) GCTCAC/TGTGAT 3 -- us2k10--------
    rs2019139471,2
    C--113210647(-) GGGTCC/TCCCAC 3 -- us2k10--------
    rs1479389741,2
    --113210735(+) AGTCTA/GTTAAG 3 -- us2k10--------
    rs355538231,2
    C,F--113210870(+) ATAATG/TTTTGA 3 -- us2k16Minor allele frequency- T:0.19NA WA EA 364
    rs1146702051,2
    F--113210955(+) CCCCCA/GCTACA 3 -- us2k11Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for OAS2 (113416200 - 113449528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for OAS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507676CNV Insertion20534489
    nsv890CNV Insertion18451855
    nsv832516CNV Gain17160897

    Human Gene Mutation Database (HGMD): OAS2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OAS2
    DNA2.0 Custom Variant and Variant Library Synthesis for OAS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603350    OMIM disorders: --

    3 diseases for OAS2:    
    About MalaCards
    west nile encephalitis    tick-borne encephalitis    eczema herpeticum

    3 diseases from the University of Copenhagen DISEASES database for OAS2:
    West Nile encephalitis     tick-borne encephalitis     Eczema herpeticum

    Find genes that share disorders with OAS2           About GenesLikeMe

    Genetic Association Database (GAD): OAS2
    Human Genome Epidemiology (HuGE) Navigator: OAS2 (6 documents)

    Export disorders for OAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OAS2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with OAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PubMed id 19923450)1, 2, 9 Lin R.J.... Lin Y.L. (J. Immunol. 2009)
    2. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PubMed id 16014697)1, 4, 9 Tessier M.C....Polychronakos C. (J. Med. Genet. 2006)
    3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    4. Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. (PubMed id 21050126)1, 4 Barkhash A.V....Brinton M.A. (J. Infect. Dis. 2010)
    5. A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients. (PubMed id 19559055)1, 4 Wu X....Liu Y. (Antiviral Res. 2009)
    6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)1, 4 King J.K....Chen P.J. (Hepatology 2002)
    9. Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase. (PubMed id 9880569)1, 2 Sarkar S.N.... Sen G.C. (J. Biol. Chem. 1999)
    10. The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases. (PubMed id 10464285)1, 2 Sarkar S.N.... Sen G.C. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4939 HGNC: 8087 AceView: OAS2 Ensembl:ENSG00000111335 euGenes: HUgn4939
    ECgene: OAS2 Kegg: 4939 H-InvDB: OAS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OAS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OAS2 gene:
    Search GeneIP for patents involving OAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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