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OAS2 Gene

protein-coding GIFtS: 63

GC12P111879

2'-5'-oligoadenylate synthetase 2, 69/71kDa
(Previous name: 2'-5'-oligoadenylate synthetase 2 (69-71 kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.7.- ^³
MGC78578 ^²

Descriptions
(2'-5')oligo(A) synthetase 2 ^²
(2-5')oligo(A) synthetase 2 ^³
2'-5'-oligoadenylate synthetase 2 ^²
2'-5'-oligoadenylate synthetase 2 (69-71 kD) ^¹, ²
2'-5'-oligoadenylate synthetase 2, 69/71kDa ^²
2'5' oligoadenylate synthetase 2 ^²
2-5A synthetase 2 ^², ³
p69 OAS / p71 OAS ^³
p69OAS / p71OAS ^³

External Ids
HGNC: 8087¹
Entrez Gene: 4939²
UniProtKB: P29728³
Ensembl: ENSG00000111335⁷

Search outside databases for aliases for OAS2 gene

Previous GC identifers: GC12P112311 GC12P112935 GC12P113199 GC12P111828

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OAS2:

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate

immune response to viral infection. The encoded protein is induced by interferons and uses

adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize

2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in

viral RNA degradation and the inhibition of viral replication. The three known members of this

gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants

encoding different isoforms have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728

Function: May play a role in mediating resistance to virus infection, control of cell growth,

differentiation, and apoptosis

Gene Wiki entry for OAS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OAS2 gene

Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.13 HGNC cytogenetic band: 12q24.2

OAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P111879: (about GC identifiers)

Start:	111,900,657 bp from pter
End:	111,933,911 bp from pter
Size:	33,255 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728 (See protein sequence)

Recommended Name: 2'-5'-oligoadenylate synthetase 2

Size: 719 amino acids; 82431 Da

Subunit: Homodimer

Subcellular location: Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated

with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal

fractions

Secondary accessions: Q86XX8

Alternative splicing: 2 isoforms: P29728-1 P29728-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001027903.1 NP_002526.2 NP_058197.2

ENSEMBL proteins:

ENSP00000342278 ENSP00000376362

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (OAS2)
	Human Recombinant Proteins from Abnova (OAS2)

OriGene Purified Recombinant Human Protein: OAS2

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005792	microsome	TAS	2440675
GO:0016020	membrane	TAS	2440675

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Antibodies for OAS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for OAS2
	Antibodies from Abcam (OAS2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (OAS2)
	Search Novus for antibodies for OAS2

Assays for OAS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P29728

ProtoNet protein and cluster: P29728

2 Blocks protein families:

IPB002934 DNA polymerase

IPB006117 2-5-oligoadenylate synthetase

UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728

Similarity: Belongs to the 2-5A synthetase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OAS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OAS2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_002535

Applied Biosystems Silencer® siRNAs for OAS2

Sigma-Aldrich siRNA for OAS2

Sigma-Aldrich shRNA for OAS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for OAS2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001032731
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001032731
untagged cDNA clones in CMV expression vector (see all 5): BC010625

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016817

UniProtKB/Swiss-Prot: OAS2_HUMAN, P29728

Function: May play a role in mediating resistance to virus infection, control of cell growth,

differentiation, and apoptosis

Catalytic activity: Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers,

which activate the latent RNase L that, when activated, cleaves single-stranded RNAs

Induction: By interferons

Enzyme Number (IUBMB): EC 2.7.7.-

Genatlas biochemistry entry for OAS2:

2',5'-oligoadenylate synthetase 2,with two alternatively spliced isoforms 69kDa,71kDa,interferon

induced

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--
GO:0016779	nucleotidyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for OAS2 (Your Favorite Gene powered by Ingenuity)

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

GeneDecks OAS2 for the pathways selected above

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2 Interacting proteins for OAS2 (ENSP00000342278³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
POLDIP3	ENSP00000252115³	STRING (score=.746)
--	ENSP00000369552³	STRING (score=.877)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	TAS	2440675
GO:0006955	immune response	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OAS2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OAS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OAS2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_002535

Sigma-Aldrich siRNA for OAS2

Sigma-Aldrich shRNA for OAS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001032731 NM_002535 NM_016817

REFSEQ mRNAs for OAS2 gene (3 alternative transcripts):

NM_001032731.1 NM_002535.2 NM_016817.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001032731 NM_002535 NM_016817

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001032731
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001032731
                                 untagged cDNA clones in CMV expression vector (see all 5): BC010625

Additional cDNA sequence:

AF074990.1 AK292796.1 AK292906.1 BC010625.1 BC023637.2 BC049215.1 BC053870.1 BC069052.1

CR592869.1 CR623050.1 M87284.1 M87434.1

7 DOTS entries:

DT.404686 DT.75168849 DT.100691521 DT.100785794 DT.121200003 DT.121200004 DT.100763558

24/184 AceView cDNA sequences (see all 184 ):

BC023637 BC049215 BE043940 BG292035 AA040536 BM927515 AW835144 AA040537

BX444261 AW835147 AW168226 AW835145 CR623050 AW835148 AW835142 BM909558

BE882346 BQ643017 BM471377 BQ007650 BM927608 CF137864 CR592869 BQ063465

highest scoring ESTs for OAS2:

M87434 AA040142 AA622883 AA769661 AA906523 AF074990 AI151437 AI521829 AI671680 AI761210

Unigene Cluster for OAS2:

2'-5'-oligoadenylate synthetase 2, 69/71kDa

Hs.414332 [show with all ESTs]

Unigene Representative Sequence: NM_002535

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for OAS2 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11
SP1:
SP2:											-
SP3:											-
SP4:
SP5:							-		-		-

About this scheme

ECgene alternative splicing isoforms for OAS2

2 Ensembl transcripts including schematic representations:

ENST00000342315 ENST00000392583

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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OAS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OAS2

¹ / ² / ³

10 probe-sets matching OAS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90662_at²^{, 3}	U95-E	1	1.00	1.00	0.94	1.13	AI340262	0.60	1.00	0.82	1
39263_at²^{, 3}	U95-A	1	1.00	1.00	0.90	1.20	M87434	1.00	1.00	1.00	1
54823_at²^{, 3}	U95-C	1	1.00	1.00	0.91	1.03	AI651594	0.60	1.00	0.82	1
39264_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.66	M87284	0.80	1.00	0.91	1
228607_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI651594	0.60	1.00	0.82	1
206553_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002535	0.60	1.00	0.82	1
204972_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016817	0.60	1.00	0.82	1
228607_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206553_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204972_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OAS2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACAGAGAAA

SOURCE GeneReport for Unigene cluster: Hs.414332
Expression variation in blood from EXPOLDB for OAS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OAS2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OAS2¹	--	2'-5'-oligoadenylate synthetase 2, 69/71kDa	79.12(n) 71.03(a)	611051 XM_848678.1 XP_853771.1
chimpanzee (Pan troglodytes)	OAS2¹	--	2'-5'-oligoadenylate synthetase 2, 69/71kDa	99.35(n) 99.03(a)	739230 XM_001151534.1 XP_001151534.1
cow (Bos taurus)	OAS2¹	--	2'-5'-oligoadenylate synthetase 2, 69/71kDa	78.37(n) 68.55(a)	529660 NM_001024557.1 NP_001019728.1
rat (Rattus norvegicus)	Oas2¹	--	2'-5'-oligoadenylate synthetase 2, 69/71kDa	70.2(n) 61.1(a)	363938 NM_001009715.1 NP_001009715.1
mouse (Mus musculus)	Oas2^{1, 5}	5 (67.20 cM)⁵	2'-5' oligoadenylate synthetase 2^{1, 5}	71.9(n)¹ 63.9(a)¹	246728¹ NM_145227.1¹ NP_660262.1¹ AB067535⁵ AF418010⁵ (see all 11)

About this table Species with no ortholog for OAS2

ENSEMBL Gene Tree for OAS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OAS2 gene

OASL² OAS1² OAS3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/224 NCBI SNPs in OAS2 are shown (see all 224 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 103)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs15895^1,2	A,C,F,H,O	111932671(-)	`ATCTCC/TAGAAG`	1	--	ut3¹ ese³		18	MN EU EA WA NA	1668
	rs2040807^1,2	A,C,F,H	111910563(-)	`TTTTCC/TTTTTC`	3	--	ut3¹ int¹ trp³		7	EU EA WA NA	558
	rs1293764^1,2	A,C,F,H	111910062(-)	`GTCTTG/AGGGAT`	3	--	ut3¹ int¹		8	EA NA EU WA	566
	rs13311^1,2	A,C,F,H	111933035(+)	`GTGATC/ATTGCT`	2	--	ut3¹ ng3¹		13	MN NA EU EA WA	1348
--	rs739901^1,2	A,C,F,H	111900046(+)	`AGAAAC/AAGACC`	3	--	ng5¹		4	EU EA WA	412
	rs1293743^1,2	A,C,F,H	111931955(-)	`AGGTAA/GCCACA`	2	--	int¹ ut3¹		5	MN EU EA WA	550
	rs1293766^1,2	A,C,F,H	111909665(-)	`TCCAGA/CGAAGA`	3	--	ut3¹ int¹ trp³		7	MN EA NA EU WA	618
	rs1058480^1,2	A,C,F,H	111933499(-)	`ccaggG/Catggg`	1	--	ut3¹ ese³		5	MN EU EA WA	580
	rs1296371^1,2	A,C,F,H	111934088(-)	`tgtagA/Gtccca`	1	--	ng3¹		4	EU EA WA	416
	rs12815666^1,2	C,F,H	111900137(+)	`tctgCC/TGCTTT`	3	--	ng5¹		8	EU EA WA	838

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HapMap Linkage Disequilibrium images for OAS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603350

1 PharmGKB disease relationship for OAS2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Human Gene Mutation Database: OAS2
Genetic Association Database: OAS2
Human Genome Epidemiology Navigator: OAS2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/23 PubMed articles for OAS2 gene (see all 23 ):

Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PubMed id 16014697)^{1, 3, 6} Tessier M.C....Polychronakos C. (2006)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{3, 4} Scherer S.E.... Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)^{3, 6} King J.K....Chen P.J. (2002)
The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases. (PubMed id 10464285)^{3, 4} Sarkar S.N.... Sen G.C. (1999)
The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. (PubMed id 9790745)^{2, 3} Hovnanian A....Hovanessian A.G. (1998)
The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains. (PubMed id 1577824)^{3, 4} Marie I. and Hovanessian A.G. (1992)
Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon. (PubMed id 2211721)^{3, 4} Marie I.... Hovanessian A.G. (1990)
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12086872)⁷ Yeoh E.J....Downing J.R. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4939	HGNC: 8087	AceView: OAS2	Ensembl:ENSG00000111335	euGenes: HUgn4939
ECgene: OAS2	H-InvDB: OAS2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for OAS2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OAS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OAS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OAS2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OAS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OAS2)
	Antibodies (OAS2)
	Chimera RNAi (OAS2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (OAS2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for OAS2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OAS2

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OAS2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for OAS2

Summaries
for OAS2

Genomic Location
for OAS2

Proteins
for OAS2

Protein Domains/
Families
for OAS2

Gene Function
for OAS2

Pathways & Interactions
for OAS2

Drugs & Compounds
for OAS2

Transcripts
for OAS2

Expression
for OAS2

Orthologs
for OAS2

Paralogs
for OAS2

SNPs/Variants
for OAS2

Disorders & Mutations
for OAS2

Medical News
for OAS2

Publications
for OAS2

Search for OAS2

Genome Databases showing OAS2

Other Databases showing OAS2

Specialized Databases showing OAS2

Licensable Technologies
for OAS2

Services
for OAS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OAS2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor OAS2

Summariesfor OAS2

Genomic Locationfor OAS2

Proteinsfor OAS2

Protein Domains/Familiesfor OAS2

Gene Functionfor OAS2

Pathways & Interactionsfor OAS2

Drugs & Compoundsfor OAS2

Transcriptsfor OAS2

Expression for OAS2

Orthologsfor OAS2

Paralogsfor OAS2

SNPs/Variantsfor OAS2

Disorders & Mutationsfor OAS2

Medical Newsfor OAS2

Publicationsfor OAS2

Search for OAS2

Genome Databases showing OAS2

Other Databases showing OAS2

Specialized Databases showing OAS2

Licensable Technologiesfor OAS2

Servicesfor OAS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OAS2

Summaries
for OAS2

Genomic Location
for OAS2

Proteins
for OAS2

Protein Domains/
Families
for OAS2

Gene Function
for OAS2

Pathways & Interactions
for OAS2

Drugs & Compounds
for OAS2

Transcripts
for OAS2

Expression
for OAS2

Orthologs
for OAS2

Paralogs
for OAS2

SNPs/Variants
for OAS2

Disorders & Mutations
for OAS2

Medical News
for OAS2

Publications
for OAS2

Licensable Technologies
for OAS2

Services
for OAS2