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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OAS1 Gene

protein-coding   GIFtS: 65
GCID: GC12P113344

2'-5'-oligoadenylate synthetase 1, 40/46kDa

(Previous name: 2',5'-oligoadenylate synthetase 1 (40-46 kD) )
(Previous symbol: OIAS)
 Explore 28 diseases affiliated with
OAS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OAS1    

Aliases
for OAS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
2'-5'-Oligoadenylate Synthetase 1, 40/46kDa1 2     2',5'-Oligo A Synthetase 12
OIAS1 2 3 5     2',5'-Oligoadenylate Synthetase 1, 40/46kDa2
IFI-41 2     2'-5' Oligoadenylate Synthetase 1 P48 Isoform2
OIASI1 2     2'-5' Oligoadenylate Synthetase 1 P52 Isoform2
(2-5')Oligo(A) Synthase 12 3     2'-5'-Oligoadenylate Synthase 12
2-5A Synthase 12 3     2'-5'-Oligoisoadenylate Synthetase 12
E18/E162 3     2-5A Synthetase 12
P46/P42 OAS2 3     EC 2.7.7.-3
2',5'-Oligoadenylate Synthetase 1 (40-46 KD)1     EC 2.7.78
(2-5')Oligo(A) Synthetase 12     

External Ids:    HGNC: 80861   Entrez Gene: 49382   Ensembl: ENSG000000891277   OMIM: 1643505   UniProtKB: P009733   

Export aliases for OAS1 gene to outside databases

Previous GC identifers: GC12P112239 GC12P112864 GC12P113127 GC12P111756 GC12P111807 GC12P110357


Summaries
for OAS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OAS1:
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to
viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific
nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L,
which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene
family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility
to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral
response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth,
differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then
bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation.
Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein
synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent
pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect
against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV)
and stimulates the alternative antiviral pathway independent of RNase L

Gene Wiki entry for OAS1


Genomic Views
for OAS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OAS1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OAS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OAS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.2

OAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAS1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113344:  view genomic region     (about GC identifiers)

Start:
 113,344,582 bp from pter      End:
 113,369,990 bp from pter
Size:
 25,409 bases      Orientation:
 plus strand

Proteins
for OAS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973 (See protein sequence)
Recommended Name: 2'-5'-oligoadenylate synthase 1  
Size: 400 amino acids; 46029 Da
Cofactor: Magnesium (Potential)
Subunit: Monomer (By similarity). Homotetramer
Subcellular location: Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted (By similarity).
Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal
fractions
Caution: PubMed:1651324 sequence was originally thought to originate from mouse
Sequence caution: Sequence=AAA39857.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA39858.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA59955.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD96726.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAA26497.1; Type=Erroneous gene model prediction;
Sequence=CAA30164.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for OAS1:
4IG8 (3D)    
Secondary accessions: A8K4N8 P04820 P29080 P29081 P78485 P78486 Q16700 Q16701 Q1PG42 Q3ZM01 Q53GC5
Q53YA4 Q6A1Z3 Q6IPC6 Q6P7N9 Q96J61
Alternative splicing: 4 isoforms:  P00973-1   P00973-2   P00973-3   P00973-4   (Ref.4 (AAA39858), Ref.6 (AAW63050) and Ref.16 (CAA26497) sequences are in conflict in position: 397:G->R)

Explore the universe of human proteins at neXtProt for OAS1: NX_P00973

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P00973

    • 4/5 DME Specific Peptides for OAS1 (P00973) (see all 5)
     LDPADPT  GEFSTCFT  SDADLVVF  KVVKGGSSGKGTTL 

    OAS1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001027581.1  NP_002525.2  NP_058132.2  

    ENSEMBL proteins: 
     ENSP00000202917   ENSP00000388001   ENSP00000415721   ENSP00000450286   ENSP00000449348  
     ENSP00000448790   ENSP00000448001   ENSP00000448348   ENSP00000449053  
    Reactome Protein details: P00973
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): OAS1
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    Novus Biologicals OAS1 Proteins
    Novus Biologicals OAS1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for OAS1
    Uscn Proteins for OAS1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA19923450
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--


    OAS1 for ontologies           About GeneDecksing



    OAS1 Antibody Products: 
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    Uscn Antibodies for OAS1
    ThermoFisher Antibodies for OAS1

    Assay Products for OAS1: 
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    Uscn ELISAs and CLIAs for OAS1

    Protein Domains /
    Families
    for OAS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    OAS1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002934 Nucleotidyltransferase
     IPR018952 2-5-oligoAdlate_synth_1_dom2/C
     IPR006117 2-5-oligoadenylate_synth_CS
     IPR006116 2-5-oligoadenylate_synth_N
     IPR026774 2-5A_synthase

    Graphical View of Domain Structure for InterPro Entry P00973

    ProtoNet protein and cluster: P00973

    1 Blocks protein family: IPB006117 2-5-oligoadenylate synthetase

    UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973
    Similarity: Belongs to the 2-5A synthase family


    Function
    for OAS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973
    Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral
    response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth,
    differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then
    bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation.
    Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein
    synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent
    pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect
    against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV)
    and stimulates the alternative antiviral pathway independent of RNase L
    Catalytic activity: Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the
    latent RNase L that, when activated, cleaves single-stranded RNAs
    Enzyme regulation: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral
    infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is
    tolerated. ssRNA or dsDNA do not act as activators
    Biophysicochemical properties: Kinetic parameters: KM=0.31 mM for ATP;
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for OAS1:
    2',5'-oligoisoadenylate synthetase 1,40kDa,46kDa,ubiquitously expressed,interferon induced

    Enzyme Numbers (IUBMB): EC 2.7.7.-1 EC 2.7.72

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OAS1
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    SwitchGear 3'UTR luciferase reporter plasmid: OAS1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: OAS1
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for OAS1

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): OAS1 (NM_002534)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00017302'-5'-oligoadenylate synthetase activity IDA12799444
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IDA12799444
    GO:0005524ATP binding TAS--
    GO:0008270zinc ion binding IDA11682059


    OAS1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for OAS1:
     Elongated cells 


    Pathways & Interactions
    for OAS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Prolactin receptor signaling
    		Development_Prolactin receptor signaling1.00
    		Development Prolactin receptor signaling1.00
    2Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61
    3Interferon gamma signaling
    		Interferon gamma signaling1.00
    		Expression of IFNG-stimulated genes0.72
    4Measles
    		Measles1.00
    		Influenza A0.35
    5Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for OAS1
        Development Prolactin receptor signaling


    1 GeneGo (Thomson Reuters) Pathway for OAS1
        Development Prolactin receptor signaling

    1 BioSystems Pathway for OAS1 
        Type II interferon signaling (IFNG)

    5/7        Reactome Pathways for OAS1 (see all 7)
        Interferon alpha/beta signaling
    Interferon gamma signaling
    Cytokine Signaling in Immune system
    Expression of IFN-induced genes
    Expression of IFNG-stimulated genes


    3         Kegg Pathways  (Kegg details for OAS1):
        Hepatitis C
    Measles
    Influenza A


    OAS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OAS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for OAS1 (ENSP000003880014) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADARENSP000003574594STRING: ENSP00000357459
    B2MENSP000003408584STRING: ENSP00000340858
    CD44ENSP000002783854STRING: ENSP00000278385
    CIITAENSP000003163284STRING: ENSP00000316328
    EGR1ENSP000002399384STRING: ENSP00000239938
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006164purine nucleotide biosynthetic process IDA11682059
    GO:0006955immune response ----
    GO:0009615response to virus IDA18931074
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0035457cellular response to interferon-alpha IDA3753689


    OAS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for OAS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OAS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OAS1

    1 DrugBank Compound for OAS1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cysteine-S-Acetamide-- --target--10592235

    2 Novoseek chemical compound relationships for OAS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 95.8 28 17024523 (2), 20121407 (1), 16014697 (1), 16824203 (1) (see all 19)
    atp 8.87 1 18421422 (1)

    Search CenterWatch for drugs/clinical trials and news about OAS1 

    Transcripts
    for OAS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for OAS1 gene (3 alternative transcripts): 
    NM_001032409.1  NM_002534.2  NM_016816.2  

    Unigene Cluster for OAS1:

    2'-5'-oligoadenylate synthetase 1, 40/46kDa
    Hs.524760  [show with all ESTs]
    Unigene Representative Sequence: NM_016816
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000202917(uc001tuc.3 uc001tud.3) ENST00000445409 ENST00000452357(uc001tub.3)
    ENST00000550883 ENST00000549820(uc010syn.2 uc010syo.2) ENST00000551241(uc009zwf.3)
    ENST00000553185 ENST00000550689 ENST00000553152 ENST00000552526 ENST00000540589


    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AJ629455.1 AK223006.1 AK225384.1 AK291003.1 AK300346.1 AK301498.1 AY730627.1 AY730628.1 
    BC000562.2 BC061587.1 BC071981.1 BT006785.1 D00068.1 DQ823040.1 DQ914956.1 X02661.1 
    X02874.1 X02875.1 X04371.1 

    9 DOTS entries:

    DT.451807  DT.100788721  DT.100788724  DT.91853434  DT.86852717  DT.75169681  DT.40224009  DT.100788722 
    DT.95300092 

    24/308 AceView cDNA sequences (see all 308):

    AI968952 BM768079 BE885446 CD368533 BM743882 BM754633 BI820655 AI372837 
    BM770573 AW014578 AW627809 CA309116 BU508005 BX104328 BE326976 AL560677 
    CA427212 CR590221 CB112445 BI909291 BQ223711 CD367657 AI424175 AU098772 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for OAS1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                -                                         -     -     -         
    SP2:                                -                                                               
    SP3:                                -                                         -     -               
    SP4:                                                                          -                     
    SP5:                                -     -                                                         


    ECgene alternative splicing isoforms for OAS1

    Expression
    for OAS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTACCCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    OAS1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OAS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OAS1

    SOURCE GeneReport for Unigene cluster: Hs.524760
        SABiosciences Expression via Pathway-Focused PCR Arrays including OAS1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for OAS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for OAS1 (if available)
    TreeFam Gene Tree for OAS1 (if available) 

    Paralogs
    for OAS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OAS1 gene
    OAS22  OASL2  OAS32  
    4 SIMAP similar genes for OAS1 using alignment to 11 protein entries:     OAS1_HUMAN (see all proteins):
    OAS3    OAS2    OASL    OASLd

    OAS1 for paralogs           About GeneDecksing



    Genomic Variants
    for OAS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/248 NCBI SNPs in OAS1 are shown (see all 248)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs11314541,2
    		C,F,H,other113348870(+) CTGGCA/C/GGCTAT 9 S R G mis136EA NS NA MN CSA WA EU 10722
    rs1903730801,2
    		--113343110(+) GAGCCC/TAGGAG 3 -- us2k10--------
    rs1452185661,2
    		--113343177(+) TGAGAC/GCCTGT 3 -- us2k10--------
    rs588573601,2
    		C,F,--113343312(+) GAGAAG/AAAAGA 3 -- us2k13Minor allele frequency- A:0.08WA 122
    rs21583901,2
    		C,F,A,H,--113343375(-) TGCAAC/GAGTTT 3 -- us2k128Minor allele frequency- G:0.11NS EA NA WA CSA 2304
    rs1825040871,2
    		--113343515(+) TGTCCC/TTGCAG 3 -- us2k10--------
    rs1858948641,2
    		--113343526(+) AGCAGA/GGCCAC 3 -- us2k10--------
    rs21074171,2
    		C,F,A,H,--113343563(-) TGCCCC/TGAGCT 3 -- us2k119Minor allele frequency- T:0.13NS NA WA CSA EA 1608
    rs1881595491,2
    		--113343698(+) CTGGTA/GCTCAT 3 -- us2k10--------
    rs1809595741,2
    		--113344001(+) TATTTC/GTGTAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for OAS1 (113344582 - 113369990 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OAS1: --
    Human Gene Mutation Database (HGMD): OAS1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for OAS1

    Disorders / Diseases
    for OAS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OAS1 for disorders           About GeneDecksing

    OMIM gene information: 164350   
    OMIM disorders: 222100  
    20/28 diseases for OAS1 (see all 28):    About MalaCards
    tick-borne encephalitis    west nile encephalitis    west nile virus    dengue hemorrhagic fever
    hemorrhagic fever    lupus erythematosus    systemic lupus erythematosus    cytomegalovirus infection
    encephalitis    multiple sclerosis    lupus nephritis    intrahepatic cholangiocarcinoma
    nephritis    rubella    hepatitis c    cholangiocarcinoma
    hepatitis b    measles    ovarian cancer    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for OAS1:
    West Nile encephalitis     Hepatitis C

    2 Novoseek disease relationships for OAS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 44.1 3 12944978 (1), 15732009 (1), 17822564 (1)
    lupus erythematosus systemic 35.2 1 16947629 (1)

    Genetic Association Database (GAD): OAS1
    Human Genome Epidemiology (HuGE) Navigator: OAS1 (21 documents)

    Export disorders for OAS1 gene to outside databases

    Publications
    for OAS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OAS1 gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with OAS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PubMed id 16014697)1, 4, 9 Tessier M.C....Polychronakos C. (2006)
    2. Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. (PubMed id 15766558)1, 4, 9 Hamano E....Keicho N. (2005)
    3. Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. (PubMed id 12944978)1, 4, 9 Knapp S....Thursz M.R. (2003)
    4. Distinct antiviral roles for human 2',5'-oligoadenyla te synthetase family members against dengue virus infection. (PubMed id 19923450)1, 2, 9 Lin R.J....Lin Y.L. (2009)
    5. Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family. (PubMed id 12799444)1, 2, 9 Eskildsen S....Hartmann R. (2003)
    6. Differential regulation of the OASL and OAS1 genes in response to viral infections. (PubMed id 19203244)1, 2 Melchjorsen J....Hartmann R. (2009)
    7. The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain. (PubMed id 18931074)1, 2 Marques J....Hartmann R. (2008)
    8. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for OAS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing OAS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4938 HGNC: 8086 AceView: OAS1 Ensembl:ENSG00000089127 euGenes: HUgn4938
    ECgene: OAS1 Kegg: 4938 H-InvDB: OAS1

    Other Databases showing OAS1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing OAS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OAS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OAS1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for OAS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for OAS1 gene:
    Search GeneIP for patents involving OAS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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