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OAS1 Gene

protein-coding   GIFtS: 69
GCID: GC12P113344

2'-5'-Oligoadenylate Synthetase 1, 40/46kDa

(Previous name: 2',5'-oligoadenylate synthetase 1 (40-46 kD))
(Previous symbol: OIAS)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
2'-5'-Oligoadenylate Synthetase 1, 40/46kDa1 2     2'-5' Oligoadenylate Synthetase 1 P48 Isoform2
OIAS1 2 3 5     2'-5' Oligoadenylate Synthetase 1 P52 Isoform2
(2-5')Oligo(A) Synthase 12 3     2'-5'-Oligoadenylate Synthase 12
2-5A Synthase 12 3     2'-5'-Oligoisoadenylate Synthetase 12
E18/E162 3     2-5A Synthetase 12
P46/P42 OAS2 3     IFI-42
2',5'-Oligoadenylate Synthetase 1 (40-46 KD)1     OIASI2
(2-5')Oligo(A) Synthetase 12     EC 2.7.7.843
2',5'-Oligo A Synthetase 12     EC 2.7.78
2',5'-Oligoadenylate Synthetase 1, 40/46kDa2     

External Ids:    HGNC: 80861   Entrez Gene: 49382   Ensembl: ENSG000000891277   OMIM: 1643505   UniProtKB: P009733   

Export aliases for OAS1 gene to outside databases

Previous GC identifers: GC12P112239 GC12P112864 GC12P113127 GC12P111756 GC12P111807 GC12P110357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OAS1 Gene:
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune
response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in
2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate
latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known
members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been
associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding
different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for OAS1 Gene:
OAS1 (2'-5'-oligoadenylate synthetase 1, 40/46kDa) is a protein-coding gene. Diseases associated with OAS1 include tick-borne encephalitis, and west nile encephalitis. GO annotations related to this gene include double-stranded RNA binding and 2'-5'-oligoadenylate synthetase activity. An important paralog of this gene is OAS2.

UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973
Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate
antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell
growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from
ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and
subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in
the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the
classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form
displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and
encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L

Gene Wiki entry for OAS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OAS1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): OAS1 promoter sequence
   Search Chromatin IP Primers for OAS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.13   HGNC cytogenetic band: 12q24.2

OAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAS1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P113344:  view genomic region     (about GC identifiers)

Start:
113,344,582 bp from pter      End:
113,369,990 bp from pter
Size:
25,409 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973 (See protein sequence)
Recommended Name: 2'-5'-oligoadenylate synthase 1  
Size: 400 amino acids; 46029 Da
Cofactor: Magnesium
Subunit: Monomer (By similarity). Homotetramer
Caution: PubMed:1651324 sequence was originally thought to originate from mouse
Sequence caution: Sequence=AAA39857.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAA39858.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAA59955.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD96726.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAA26497.1; Type=Erroneous gene model prediction;
Sequence=CAA30164.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for OAS1:
4IG8 (3D)    
Secondary accessions: A8K4N8 P04820 P29080 P29081 P78485 P78486 Q16700 Q16701 Q1PG42 Q3ZM01
Q53GC5 Q53YA4 Q6A1Z3 Q6IPC6 Q6P7N9 Q96J61
Alternative splicing: 4 isoforms:  P00973-1   P00973-2   P00973-3   P00973-4   (Ref.4 (AAA39858), Ref.6 (AAW63050) and Ref.16 (CAA26497) sequences are in conflict in position: 397:G->R)

Explore the universe of human proteins at neXtProt for OAS1: NX_P00973

Explore proteomics data for OAS1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for OAS1 (P00973) (see all 5)
     LDPADPT  GEFSTCFT  SDADLVVF  KVVKGGSSGKGTTL 


    See OAS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001027581.1  NP_002525.2  NP_058132.2  

    ENSEMBL proteins: 
     ENSP00000202917   ENSP00000388001   ENSP00000415721   ENSP00000450286   ENSP00000448790  
     ENSP00000448001   ENSP00000448348   ENSP00000449053   ENSP00000475139   ENSP00000474083  
    Reactome Protein details: P00973

    OAS1 Human Recombinant Protein Products:

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    OriGene MassSpec for OAS1
    OriGene Custom Protein Services for OAS1
    GenScript Custom Purified and Recombinant Proteins Services for OAS1
    Novus Biologicals OAS1 Proteins
    Novus Biologicals OAS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for OAS1
    Cloud-Clone Corp. Proteins for OAS1

    OAS1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for OAS1
    Cloud-Clone Corp. Antibodies for OAS1
    ThermoFisher Antibodies for OAS1
    LSBio Antibodies in human, mouse, rat for OAS1

    OAS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OAS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OAS1
    Cloud-Clone Corp. CLIAs for OAS1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR002934 Nucleotidyltransferase
     IPR018952 2-5-oligoAdlate_synth_1_dom2/C
     IPR006117 2-5-oligoadenylate_synth_CS
     IPR006116 2-5-oligoadenylate_synth_N
     IPR026774 2-5A_synthase

    Graphical View of Domain Structure for InterPro Entry P00973

    ProtoNet protein and cluster: P00973

    1 Blocks protein domain: IPB006117 2-5-oligoadenylate synthetase

    UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973
    Similarity: Belongs to the 2-5A synthase family


    OAS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OAS1_HUMAN, P00973
    Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate
    antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell
    growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from
    ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and
    subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in
    the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the
    classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form
    displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and
    encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L
    Catalytic activity: 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate
    Enzyme regulation: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral
    infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group
    is tolerated. ssRNA or dsDNA do not act as activators
    Biophysicochemical properties: Kinetic parameters: KM=0.31 mM for ATP;
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for OAS1:
    2',5'-oligoisoadenylate synthetase 1,40kDa,46kDa,ubiquitously expressed,interferon induced

         Enzyme Numbers (IUBMB): EC 2.7.7.841 EC 2.7.72

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00017302'-5'-oligoadenylate synthetase activity IDA11682059
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding IDA12799444
    GO:0005515protein binding IPI--
    GO:0005524ATP binding TAS--
         
    OAS1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OAS1:
     Elongated cells 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Oas1g):
     skeleton 

    OAS1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OAS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OAS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OAS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OAS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target OAS1:
    hsa-mir-335-5p (MIRT018171)

    Block miRNA regulation of human, mouse, rat OAS1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate OAS1
    SwitchGear 3'UTR luciferase reporter plasmidOAS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OAS1
    Predesigned siRNA for gene silencing in human, mouse, rat OAS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OAS1

    Clone
    Products:
         
    OriGene clones in human, mouse for OAS1 (see all 17)
    OriGene ORF clones in mouse, rat for OAS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): OAS1 (NM_002534)
    Sino Biological Human cDNA Clone for OAS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OAS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OAS1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for OAS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for OAS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OAS1_HUMAN, P00973: Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted (By
    similarity). Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and
    rough/smooth microsomal fractions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytosol4
    extracellular2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA19923450
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--

    OAS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OAS1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34
    3Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43
    4Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    5Type II interferon signaling (IFNG)
    Type II interferon signaling (IFNG)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for OAS1
        Development Prolactin receptor signaling

    1 BioSystems Pathway for OAS1
        Type II interferon signaling (IFNG)


    2 Reactome Pathways for OAS1
        Interferon alpha/beta signaling
    Interferon gamma signaling


    4 Kegg Pathways  (Kegg details for OAS1):
        Hepatitis C
    Measles
    Influenza A
    Herpes simplex infection


    OAS1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OAS1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OAS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OAS1 (P009731 ENSP000003880014) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT6Q96LA81EBI-3932815,EBI-912440
    ADARENSP000003574594STRING: ENSP00000357459
    B2MENSP000003408584STRING: ENSP00000340858
    CD44ENSP000002783854STRING: ENSP00000278385
    CIITAENSP000003163284STRING: ENSP00000316328
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006006glucose metabolic process IMP--
    GO:0006164purine nucleotide biosynthetic process IDA11682059
    GO:0006955immune response ----
    GO:0009615response to virus IDA18931074
    GO:0019221cytokine-mediated signaling pathway TAS--

    OAS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OAS1

    1 DrugBank Compound for OAS1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cysteine-S-Acetamide-- --target--10592235

    2 Novoseek inferred chemical compound relationships for OAS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 95.8 28 17024523 (2), 20121407 (1), 16014697 (1), 16824203 (1) (see all 19)
    atp 8.87 1 18421422 (1)



    OAS1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OAS1 gene (3 alternative transcripts): 
    NM_001032409.1  NM_002534.2  NM_016816.2  

    Unigene Cluster for OAS1:

    2'-5'-oligoadenylate synthetase 1, 40/46kDa
    Hs.524760  [show with all ESTs]
    Unigene Representative Sequence: NM_016816
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000202917(uc001tuc.3 uc001tud.3) ENST00000445409 ENST00000452357(uc001tub.3)
    ENST00000550883 ENST00000549820(uc010syn.2 uc010syo.2) ENST00000551241(uc009zwf.3)
    ENST00000553185 ENST00000550689 ENST00000553152 ENST00000552526 ENST00000540589

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): OAS1 (NM_002534)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OAS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OAS1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat OAS1
      QuantiFast Probe-based Assays in human, mouse, rat OAS1

    Additional mRNA sequence: 

    AJ629455.1 AK223006.1 AK225384.1 AK291003.1 AK300346.1 AK301498.1 AY730627.1 AY730628.1 
    BC000562.2 BC061587.1 BC071981.1 BT006785.1 D00068.1 DQ823040.1 DQ914956.1 X02661.1 
    X02874.1 X02875.1 X04371.1 

    9 DOTS entries:

    DT.451807  DT.100788721  DT.100788724  DT.91853434  DT.86852717  DT.75169681  DT.40224009  DT.100788722 
    DT.95300092 

    Selected AceView cDNA sequences (see all 308):

    AU076579 CD367657 AW627809 CB112445 BU626674 AI424175 AA053004 CD366472 
    BI820655 AI471376 BM754633 BM743882 CA309116 CA432570 AV654890 AI968952 
    AW014578 CA443364 BF795933 CR621070 AA968953 BM745160 BM768079 BC000562 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OAS1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                -                                         -     -     -         
    SP2:                                -                                                               
    SP3:                                -                                         -     -               
    SP4:                                                                          -                     
    SP5:                                -     -                                                         


    ECgene alternative splicing isoforms for OAS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTACCCTCA
    OAS1 Expression
    About this image


    OAS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
     
     Colon (Gastrointestinal Tract)
     
     Stomach (Gastrointestinal Tract)
    OAS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OAS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524760
        Pathway & Disease-focused RT2 Profiler PCR Arrays including OAS1: 
              Interferons & Receptors in human mouse rat
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OAS1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oas1g1 , 5 2'-5' oligoadenylate synthetase 1G1, 5 75(n)1
    72.06(a)1
      5 (60.65 cM)5
    239601  NM_011852.21  NP_035982.21 
     1208761425 


    ENSEMBL Gene Tree for OAS1 (if available)
    TreeFam Gene Tree for OAS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OAS1 gene
    OAS22  OASL2  OAS32  
    3 SIMAP similar genes for OAS1 using alignment to 11 protein entries:     OAS1_HUMAN (see all proteins):
    OAS3    OAS2    OASL

    OAS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OAS1 (see all 334)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11314541,2,,4
    C,F,Hother1113144361(+) CTGGCA/C/GGCTAT 6 S G mis136EA NS NA MN CSA WA EU 10722
    rs1903730801,2
    --113138601(+) GAGCCC/TAGGAG 3 -- us2k10--------
    rs1452185661,2
    --113138668(+) TGAGAC/GCCTGT 3 -- us2k10--------
    rs588573601,2
    C,F--113138803(+) GAGAAG/AAAAGA 3 -- us2k13Minor allele frequency- A:0.08WA 122
    rs21583901,2
    C,F,A,H--113138866(-) tgcaAC/Gagttt 3 -- us2k128Minor allele frequency- G:0.11NS EA NA WA CSA 2304
    rs1825040871,2
    --113139006(+) TGTCCC/TTGCAG 3 -- us2k10--------
    rs1858948641,2
    --113139017(+) AGCAGA/GGCCAC 3 -- us2k10--------
    rs21074171,2
    C,F,A,H--113139054(-) tgcccC/Tgagct 3 -- us2k119Minor allele frequency- T:0.13NS NA WA CSA EA 1608
    rs1881595491,2
    --113139189(+) CTGGTA/GCTCAT 3 -- us2k10--------
    rs1809595741,2
    --113139492(+) TATTTC/GTGTAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for OAS1 (113344582 - 113369990 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OAS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832516CNV Gain17160897
    nsv832515CNV Gain17160897

    Human Gene Mutation Database (HGMD): OAS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OAS1
    DNA2.0 Custom Variant and Variant Library Synthesis for OAS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164350   
    OMIM disorders: 222100  
    Selected diseases for OAS1 (see all 32):    
    About MalaCards
    tick-borne encephalitis    west nile encephalitis    viral infectious disease    west nile virus
    type 1 diabetes    rubella    dengue hemorrhagic fever    cytomegalovirus infection
    encephalitis    hepatitis b virus infection    hepatitis c virus    hemorrhagic fever
    stomatitis    lupus nephritis    measles    hepatitis b
    nephritis    lupus erythematosus    herpes simplex    intrahepatic cholangiocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for OAS1:
    West Nile encephalitis     Hepatitis C

    OAS1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for OAS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 44.1 3 12944978 (1), 15732009 (1), 17822564 (1)
    lupus erythematosus systemic 35.2 1 16947629 (1)

    Genetic Association Database (GAD): OAS1
    Human Genome Epidemiology (HuGE) Navigator: OAS1 (21 documents)

    Export disorders for OAS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OAS1 gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with OAS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication. (PubMed id 19515215)1, 4, 9 Li C.Z....Omata M. (Liver Int. 2009)
    2. OAS1 gene haplotype confers susceptibility to multiple sclerosis. (PubMed id 17092260)1, 4, 9 Fedetz M....Alcina A. (Tissue Antigens 2006)
    3. Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case-control study. (PubMed id 16824203)1, 4, 9 He J....Cao W. (BMC Infect. Dis. 2006)
    4. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PubMed id 16014697)1, 4, 9 Tessier M.C....Polychronakos C. (J. Med. Genet. 2006)
    5. Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. (PubMed id 15766558)1, 4, 9 Hamano E....Keicho N. (Biochem. Biophys. Res. Commun. 2005)
    6. Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. (PubMed id 12944978)1, 4, 9 Knapp S....Thursz M.R. (Genes Immun. 2003)
    7. Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection. (PubMed id 19923450)1, 2, 9 Lin R.J.... Lin Y.L. (J. Immunol. 2009)
    8. Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin- like family. (PubMed id 12799444)1, 2, 9 Eskildsen S.... Hartmann R. (Nucleic Acids Res. 2003)
    9. Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1. (PubMed id 23319625)1, 2 Donovan J....Korennykh A. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    10. Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. (PubMed id 21050126)1, 4 Barkhash A.V....Brinton M.A. (J. Infect. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4938 HGNC: 8086 AceView: OAS1 Ensembl:ENSG00000089127 euGenes: HUgn4938
    ECgene: OAS1 Kegg: 4938 H-InvDB: OAS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OAS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OAS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OAS1 gene:
    Search GeneIP for patents involving OAS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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