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OAS1 Gene

protein-coding GIFtS: 65

GC12P111807

2',5'-oligoadenylate synthetase 1, 40/46kDa
(Previous name: 2',5'-oligoadenylate synthetase 1 (40-46 kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: OIAS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
E18/E16 ^³
EC 2.7.7.- ^³
IFI-4 ^¹, ²
OIAS ^², ³, ⁵
OIASI ^¹, ²

Descriptions
(2-5')oligo(A) synthetase 1 ^³
2',5'-oligo A synthetase 1 ^²
2',5'-oligoadenylate synthetase 1 ^²
2',5'-oligoadenylate synthetase 1 (40-46 kD) ^¹, ²
2',5'-oligoadenylate synthetase 1, 40/46kDa ^²
2'-5' oligoadenylate synthetase 1 p48 isoform ^²
2'-5' oligoadenylate synthetase 1 p52 isoform ^²
2'-5'-oligoisoadenylate synthetase 1 ^²
2-5A synthetase 1 ^², ³
p46/p42 OAS ^³

External Ids
HGNC: 8086¹
Entrez Gene: 4938²
UniProtKB: P00973³
Ensembl: ENSG00000089127⁷

Search outside databases for aliases for OAS1 gene

Previous GC identifers: GC12P112239 GC12P112864 GC12P113127 GC12P111756

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for OAS1:

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate

immune response to viral infection. The encoded protein is induced by interferons and uses

adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize

2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in

viral RNA degradation and the inhibition of viral replication. The three known members of this

gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated

with host susceptibility to viral infection. Alternatively spliced transcript variants encoding

different isoforms have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973

Function: May play a role in mediating resistance to virus infection, control of cell growth,

differentiation, and apoptosis

Gene Wiki entry for OAS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OAS1 gene

Entrez Gene cytogenetic band: 12q24.1 Ensembl cytogenetic band: 12q24.13 HGNC cytogenetic band: 12q24.2

OAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P111807: (about GC identifiers)

Start:	111,829,122 bp from pter
End:	111,854,177 bp from pter
Size:	25,056 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973 (See protein sequence)

Recommended Name: 2'-5'-oligoadenylate synthetase 1

Size: 400 amino acids; 46059 Da

Subunit: Homotetramer

Subcellular location: Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Note=Associated

with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal

fractions

Caution: PubMed:1651324 sequence was originally thought to originate from mouse

Sequence caution: Sequence=CAA26497.1; Type=Frameshift; Positions=400;

Secondary accessions: A8K4N8 P04820 P29080 P29081 P78485 P78486 Q16700 Q16701 Q1PG42 Q3ZM01 Q53GC5

Q53YA4 Q6A1Z3 Q6IPC6 Q6P7N9 Q96J61

Alternative splicing: 4 isoforms: P00973-1 P00973-2 P00973-3 P00973-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001027581.1 NP_002525.2 NP_058132.2

ENSEMBL proteins:

ENSP00000366730 ENSP00000355339 ENSP00000202917

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (OAS1)
	Human Recombinant Proteins from Abnova (OAS1)

OriGene Purified Recombinant Human Protein: OAS1

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	TAS	3754863
GO:0005739	mitochondrion	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005792	microsome	IEA	--

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Antibodies for OAS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for OAS1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (OAS1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (OAS1)
	Novus Biologicals Antibodies for OAS1

Assays for OAS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P00973

ProtoNet protein and cluster: P00973

1 Blocks protein family: IPB006117 2-5-oligoadenylate synthetase

UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973

Similarity: Belongs to the 2-5A synthetase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OAS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OAS1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002534

Applied Biosystems Silencer® siRNAs for OAS1

Sigma-Aldrich siRNA for OAS1

Sigma-Aldrich shRNA for OAS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001032409
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001032409
untagged cDNA clones in CMV expression vector (see all 3): NM_001032409

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001032409

UniProtKB/Swiss-Prot: OAS1_HUMAN, P00973

Function: May play a role in mediating resistance to virus infection, control of cell growth,

differentiation, and apoptosis

Catalytic activity: Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers,

which activate the latent RNase L that, when activated, cleaves single-stranded RNAs

Induction: By interferons

Enzyme Number (IUBMB): EC 2.7.7.-

Genatlas biochemistry entry for OAS1:

2',5'-oligoisoadenylate synthetase 1,40kDa,46kDa,ubiquitously expressed,interferon induced

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--
GO:0016779	nucleotidyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for OAS1 (Your Favorite Gene powered by Ingenuity)

Interferon Signaling
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

GeneDecks OAS1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for OAS1

5/9 Interacting proteins for OAS1 (ENSP00000202917³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ISG15	ENSP00000368699³	STRING (score=.838)
POLDIP3	ENSP00000252115³	STRING (score=.805)
STAT1	ENSP00000354394³	STRING (score=.8)
IL29	ENSP00000329991³	STRING (score=.796)
IRF7	ENSP00000329411³	STRING (score=.776)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	TAS	2440675
GO:0006955	immune response	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OAS1
1 Novoseek chemical compound relationship for OAS1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	14.94	1	18421422 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OAS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (OAS1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002534

Sigma-Aldrich siRNA for OAS1

Sigma-Aldrich shRNA for OAS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001032409 NM_002534 NM_016816

REFSEQ mRNAs for OAS1 gene (3 alternative transcripts):

NM_001032409.1 NM_002534.2 NM_016816.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001032409 NM_002534 NM_016816

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001032409
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001032409
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001032409

Additional cDNA sequence:

AJ629455.1 AK223006.1 AK225384.1 AK291003.1 AK300346.1 AK301498.1 AY730627.1 AY730628.1

BC000562.2 BC061587.1 BC071981.1 BT006785.1 CR590221.1 CR603997.1 CR613331.1 CR621070.1

CR626748.1 D00068.1 DQ914956.1 X02661.1 X02874.1 X02875.1 X04371.1

9 DOTS entries:

DT.451807 DT.100788721 DT.100788724 DT.91853434 DT.86852717 DT.75169681 DT.40224009 DT.100788722

DT.95300092

24/308 AceView cDNA sequences (see all 308 ):

AL560677 CF272298 BC000562 CB119011 AL582281 BM754633 AA968953 AI424175

AW627809 AV654890 CA311314 AU098772 AA872654 AU076579 AA947218 BI909291

CR603997 BQ233142 CD366298 CR621070 CA427212 CD368533 BX104328 BE295499

highest scoring ESTs for OAS1:

AA053004 AA586776 AA721487 AA812259 AI214259 AI247323 AI687538 AI806136 AI832458 AI859271

Unigene Cluster for OAS1:

2',5'-oligoadenylate synthetase 1, 40/46kDa

Hs.524760 [show with all ESTs]

Unigene Representative Sequence: NM_016816

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for OAS1 (see all 7 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9
SP1:											-														-		-		-
SP2:											-
SP3:											-														-		-
SP4:																									-
SP5:											-		-

About this scheme

ECgene alternative splicing isoforms for OAS1

3 Ensembl transcripts including schematic representations:

ENST00000377508 ENST00000361629 ENST00000202917

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OAS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OAS1

¹ / ² / ³

6 probe-sets matching OAS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38389_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.92	X04371	0.80	1.00	0.91	1
38388_at²^{, 3}	U95-A	1	1.00	1.00	0.92	1.09	M11810	0.20	1.00	0.72	1
205552_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002534	0.60	1.00	0.82	1
202869_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016816	0.60	1.00	0.82	1
205552_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202869_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks OAS1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGTACCCTCA

SOURCE GeneReport for Unigene cluster: Hs.524760
Expression variation in blood from EXPOLDB for OAS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OAS1 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OAS1¹	--	2',5'-oligoadenylate synthetase 1, 40/46kDa	69.7(n) 62.03(a)	608778 XM_845646.1 XP_850739.1
cow (Bos taurus)	OAS1¹	--	2',5'-oligoadenylate synthetase 1, 40/46kDa	77.81(n) 71.85(a)	347699 NM_178108.2 NP_835209.1
rat (Rattus norvegicus)	Oas1a¹	--	2'-5' oligoadenylate synthetase 1A	74.58(n) 70.97(a)	192281 NM_138913.1 NP_620268.1
mouse (Mus musculus)	Oas1g^{1, 5}	5 (67.00 cM)⁵	2'-5' oligoadenylate synthetase 1G^{1, 5}	75(n)¹ 72.06(a)¹	23960¹ NM_011852.2¹ NP_035982.2¹ AF480417⁵ AI449562⁵ (see all 8)

About this table Species with no ortholog for OAS1

ENSEMBL Gene Tree for OAS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for OAS1 gene

OAS2² OASL² OAS3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/72 NCBI SNPs in OAS1 are shown (see all 72 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 80)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2158390^1,2	A,C,F,H	111827758(-)	`tgcaAC/Gagttt`	3	--	ng5¹		11		EU EA WA NA	976
	rs7135577^1,2	A,C,F,H	111842489(+)	`CATGTG/ATCAAA`	2	--	ng3¹		4		EU EA WA	414
	rs2660^1,2	A,C,F,H	111841825(+)	`AGAGAA/GGACAA`	2	G/R	mis¹ ut3¹ ese³		22		MN NA EU EA WA CSAM	1940
--	rs1051042^1,2	A,C,F,H	111841620(+)	`CAGGAC/GGTATC`	2	R/T	mis¹ int¹ ese³		22		MN EU EA WA NA CSAM	2004
	rs12322047^1,2	A,F,H	111828555(+)	`gttgcA/Gcgagt`	3	--	ng5¹		4		EU EA WA	420
	rs11836381^1,2	C,F,H	111841690(+)	`CTCCAG/AGCAGC`	2	S/G Q/Q	mis¹ syn¹ ese³		9		EU EA WA MN CSAM	828
--	rs1015542^1,2	A,C	111828529(-)	`TCAAGC/GGATCC`	3	--	ng5¹		0	--	--	--	--
--	rs2107417^1,2	A,C	111827946(-)	`tgcccC/Tgagct`	3	--	ng5¹		0	--	--	--	--
--	rs1131476^1,2	C	111841592(+)	`ACAGTA/GCAGAC`	2	A/T	mis¹ int¹		17		EU EA WA NA MN CSAM	1456
	rs35919998^1,2	F	111841599(+)	`AGACGA/GTGAGA`	2	D/G	mis¹ int¹		5		MN CSAM EA	408

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HapMap Linkage Disequilibrium images for OAS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164350

2 Novoseek disease relationships for OAS1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
virus infection	42.51	3	12944978 (1), 15732009 (1), 17822564 (1)
lupus erythematosus systemic	20.16	1	16947629 (1)

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Human Gene Mutation Database: OAS1
Genetic Association Database: OAS1
Human Genome Epidemiology Navigator: OAS1 (9 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/61 PubMed articles for OAS1 gene (see all 61 ):

Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PubMed id 16014697)^{1, 3, 6} Tessier M.C....Polychronakos C. (2006)
Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. (PubMed id 15766558)^{1, 3, 6} Hamano E....Keicho N. (2005)
Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. (PubMed id 12944978)^{1, 3, 6} Knapp S....Thursz M.R. (2003)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{3, 4} Scherer S.E.... Gibbs R.A. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: A pilot study. (PubMed id 12447867)^{3, 6} King J.K....Chen P.J. (2002)
The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases. (PubMed id 10464285)^{3, 4} Sarkar S.N.... Sen G.C. (1999)
Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein. (PubMed id 9407111)^{3, 4} Ghosh A.... Sen G.C. (1997)
Cloning, sequencing, and expression of two murine 2'-5'- oligoadenylate synthetases. Structure-function relationships. (PubMed id 1651324)^{3, 4} Ghosh S.K....Sen G.C. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4938	HGNC: 8086	AceView: OAS1	Ensembl:ENSG00000089127	euGenes: HUgn4938
ECgene: OAS1	H-InvDB: OAS1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for OAS1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for OAS1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for OAS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OAS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OAS1		Antibodies for OAS1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OAS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (OAS1)
	Antibodies (OAS1)
	Chimera RNAi (OAS1)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (OAS1)
	Antibodies (OAS1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for OAS1

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Antibodies for OAS1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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OAS1 Gene at Home site.
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OAS1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for OAS1

Summaries
for OAS1

Genomic Location
for OAS1

Proteins
for OAS1

Protein Domains/
Families
for OAS1

Gene Function
for OAS1

Pathways & Interactions
for OAS1

Drugs & Compounds
for OAS1

Transcripts
for OAS1

Expression
for OAS1

Orthologs
for OAS1

Paralogs
for OAS1

SNPs/Variants
for OAS1

Disorders & Mutations
for OAS1

Medical News
for OAS1

Publications
for OAS1

Search for OAS1

Genome Databases showing OAS1

Other Databases showing OAS1

Specialized Databases showing OAS1

Licensable Technologies
for OAS1

Services
for OAS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OAS1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor OAS1

Summariesfor OAS1

Genomic Locationfor OAS1

Proteinsfor OAS1

Protein Domains/Familiesfor OAS1

Gene Functionfor OAS1

Pathways & Interactionsfor OAS1

Drugs & Compoundsfor OAS1

Transcriptsfor OAS1

Expression for OAS1

Orthologsfor OAS1

Paralogsfor OAS1

SNPs/Variantsfor OAS1

Disorders & Mutationsfor OAS1

Medical Newsfor OAS1

Publicationsfor OAS1

Search for OAS1

Genome Databases showing OAS1

Other Databases showing OAS1

Specialized Databases showing OAS1

Licensable Technologiesfor OAS1

Servicesfor OAS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OAS1

Summaries
for OAS1

Genomic Location
for OAS1

Proteins
for OAS1

Protein Domains/
Families
for OAS1

Gene Function
for OAS1

Pathways & Interactions
for OAS1

Drugs & Compounds
for OAS1

Transcripts
for OAS1

Expression
for OAS1

Orthologs
for OAS1

Paralogs
for OAS1

SNPs/Variants
for OAS1

Disorders & Mutations
for OAS1

Medical News
for OAS1

Publications
for OAS1

Licensable Technologies
for OAS1

Services
for OAS1