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Aliases for OAS1 Gene

Aliases for OAS1 Gene

  • 2'-5'-Oligoadenylate Synthetase 1, 40/46kDa 2
  • OIAS 3 4 6
  • 2-5-Oligoadenylate Synthetase 1, 40/46kDa 2 3
  • (2-5)Oligo(A) Synthase 1 3 4
  • 2-5A Synthase 1 3 4
  • P46/P42 OAS 3 4
  • E18/E16 3 4
  • 2-5 Oligoadenylate Synthetase 1 P48 Isoform 3
  • 2-5 Oligoadenylate Synthetase 1 P52 Isoform 3
  • 2,5-Oligoadenylate Synthetase 1 (40-46 KD) 2
  • 2,5-Oligoadenylate Synthetase 1, 40/46kDa 3
  • 2-5-Oligoisoadenylate Synthetase 1 3
  • 2-5-Oligoadenylate Synthase 1 3
  • (2-5)Oligo(A) Synthetase 1 3
  • 2,5-Oligo A Synthetase 1 3
  • 2-5A Synthetase 1 3
  • EC 2.7.7.84 4
  • EC 2.7.7 63
  • IFI-4 3
  • OIASI 3

External Ids for OAS1 Gene

Previous Symbols for OAS1 Gene

  • OIAS

Summaries for OAS1 Gene

Entrez Gene Summary for OAS1 Gene

  • This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for OAS1 Gene

OAS1 (2'-5'-Oligoadenylate Synthetase 1, 40/46kDa) is a Protein Coding gene. Diseases associated with OAS1 include tick-borne encephalitis and west nile encephalitis. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include double-stranded RNA binding and 2-5-oligoadenylate synthetase activity. An important paralog of this gene is OAS2.

UniProtKB/Swiss-Prot for OAS1 Gene

  • Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Gene Wiki entry for OAS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAS1 Gene

Genomics for OAS1 Gene

Genomic Location for OAS1 Gene

Start:
112,906,777 bp from pter
End:
112,932,185 bp from pter
Size:
25,409 bases
Orientation:
Plus strand

Genomic View for OAS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAS1 Gene

Regulatory Elements for OAS1 Gene

Transcription factor binding sites by QIAGEN in the OAS1 gene promoter:

Proteins for OAS1 Gene

  • Protein details for OAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00973-OAS1_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase 1
    Protein Accession:
    P00973
    Secondary Accessions:
    • A8K4N8
    • P04820
    • P29080
    • P29081
    • P78485
    • P78486
    • Q16700
    • Q16701
    • Q1PG42
    • Q3ZM01
    • Q53GC5
    • Q53YA4
    • Q6A1Z3
    • Q6IPC6
    • Q6P7N9
    • Q96J61

    Protein attributes for OAS1 Gene

    Size:
    400 amino acids
    Molecular mass:
    46029 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer (By similarity). Homotetramer.
    SequenceCaution:
    • Sequence=AAA39857.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA39858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA59955.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96726.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA26497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAA30164.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OAS1 Gene

    Alternative splice isoforms for OAS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OAS1 Gene

Proteomics data for OAS1 Gene at MOPED

Selected DME Specific Peptides for OAS1 Gene

Post-translational modifications for OAS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for OAS1 Gene

Graphical View of Domain Structure for InterPro Entry

P00973

UniProtKB/Swiss-Prot:

OAS1_HUMAN
Family:
  • Belongs to the 2-5A synthase family.:
    • P00973
genes like me logo Genes that share domains with OAS1: view

No data available for Gene Families for OAS1 Gene

Function for OAS1 Gene

Molecular function for OAS1 Gene

GENATLAS Biochemistry: 2,5-oligoisoadenylate synthetase 1,40kDa,46kDa,ubiquitously expressed,interferon induced
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.31 mM for ATP {ECO:0000269 PubMed:12799444};
UniProtKB/Swiss-Prot CatalyticActivity: 3 ATP = pppA2p5A2p5A + 2 diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators.
UniProtKB/Swiss-Prot Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2-5-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
UniProtKB/Swiss-Prot Induction: By type I interferon (IFN) and viruses.

Enzyme Numbers (IUBMB) for OAS1 Gene

Gene Ontology (GO) - Molecular Function for OAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 2-5-oligoadenylate synthetase activity IDA 11682059
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IDA 12799444
GO:0005515 protein binding IPI 15039538
GO:0005524 ATP binding TAS 21142819
genes like me logo Genes that share ontologies with OAS1: view

Phenotypes for OAS1 Gene

MGI mutant phenotypes for OAS1:
inferred from 1 alleles
GenomeRNAi human phenotypes for OAS1:
genes like me logo Genes that share phenotypes with OAS1: view

miRNA for OAS1 Gene

miRTarBase miRNAs that target OAS1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for OAS1 Gene

Localization for OAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OAS1 Gene

Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OAS1 Gene COMPARTMENTS Subcellular localization image for OAS1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 4
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for OAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 19923450
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with OAS1: view

Pathways for OAS1 Gene

genes like me logo Genes that share pathways with OAS1: view

Pathways by source for OAS1 Gene

Gene Ontology (GO) - Biological Process for OAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process IMP 23575436
GO:0006164 purine nucleotide biosynthetic process IDA 11682059
GO:0006955 immune response --
GO:0008152 metabolic process --
GO:0009615 response to virus IDA 18931074
genes like me logo Genes that share ontologies with OAS1: view

Compounds for OAS1 Gene

(1) Drugbank Compounds for OAS1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cysteine-S-Acetamide
target

(2) Novoseek inferred chemical compound relationships for OAS1 Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 95.8 20
atp 8.87 1
genes like me logo Genes that share compounds with OAS1: view

Transcripts for OAS1 Gene

Unigene Clusters for OAS1 Gene

2-5-oligoadenylate synthetase 1, 40/46kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OAS1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - - -
SP2: -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7: - - - - - -

Relevant External Links for OAS1 Gene

GeneLoc Exon Structure for
OAS1
ECgene alternative splicing isoforms for
OAS1

Expression for OAS1 Gene

mRNA expression in normal human tissues for OAS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAS1 Gene

This gene is overexpressed in Whole Blood (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OAS1 Gene

SOURCE GeneReport for Unigene cluster for OAS1 Gene Hs.524760

genes like me logo Genes that share expressions with OAS1: view

No data available for mRNA Expression by UniProt/SwissProt for OAS1 Gene

Orthologs for OAS1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAS1 35
  • 98.67 (n)
  • 96.25 (a)
OAS1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OAS1X 35
  • 77.81 (n)
  • 71.85 (a)
OAS1Y 36
  • 67 (a)
OneToMany
OAS1Z 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OAS1 35
  • 77.84 (n)
  • 73.01 (a)
OAS1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oas1a 36
  • 66 (a)
OneToMany
Oas1b 36
  • 58 (a)
OneToMany
Oas1c 36
  • 50 (a)
OneToMany
Oas1d 36
  • 50 (a)
OneToMany
Oas1e 36
  • 51 (a)
OneToMany
Oas1f 36
  • 55 (a)
OneToMany
Oas1g 35
  • 75 (n)
  • 72.06 (a)
Oas1g 16
Oas1g 36
  • 67 (a)
OneToMany
Oas1h 36
  • 49 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OAS1 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oas1a 35
  • 74.58 (n)
  • 70.97 (a)
Species with no ortholog for OAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OAS1 Gene

ENSEMBL:
Gene Tree for OAS1 (if available)
TreeFam:
Gene Tree for OAS1 (if available)

Paralogs for OAS1 Gene

Paralogs for OAS1 Gene

genes like me logo Genes that share paralogs with OAS1: view

Variants for OAS1 Gene

Sequence variations from dbSNP and Humsavar for OAS1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2660 -- 112,919,637(+) AGAGA(A/G)GACAA missense, reference, utr-variant-3-prime
rs757398 -- 112,909,277(-) TTTTA(C/T)CAATT intron-variant
rs1015542 -- 112,906,341(-) TCAAG(C/G)GATCC upstream-variant-2KB
rs1050994 - 112,907,130(+) AAATC(A/G)ACCAT reference, missense
rs1050995 -- 112,908,698(+) GAGCA(C/T)TTTCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OAS1 Gene

Variant ID Type Subtype PubMed ID
nsv832515 CNV Gain 17160897
nsv832516 CNV Gain 17160897

Relevant External Links for OAS1 Gene

HapMap Linkage Disequilibrium report
OAS1
Human Gene Mutation Database (HGMD)
OAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAS1 Gene

Disorders for OAS1 Gene

(1) OMIM Diseases for OAS1 Gene (164350)

(2) University of Copenhagen DISEASES for OAS1 Gene

(2) Novoseek inferred disease relationships for OAS1 Gene

Disease -log(P) Hits PubMed IDs
virus infection 44.1 3
lupus erythematosus systemic 35.2 1

Relevant External Links for OAS1

Genetic Association Database (GAD)
OAS1
Human Genome Epidemiology (HuGE) Navigator
OAS1
genes like me logo Genes that share disorders with OAS1: view

No data available for UniProtKB/Swiss-Prot for OAS1 Gene

Publications for OAS1 Gene

  1. Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin- like family. (PMID: 12799444) Eskildsen S. … Hartmann R. (Nucleic Acids Res. 2003) 3 4 23
  2. Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. (PMID: 12944978) Knapp S. … Thursz M.R. (Genes Immun. 2003) 3 23 48
  3. Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. (PMID: 15766558) Hamano E. … Keicho N. (Biochem. Biophys. Res. Commun. 2005) 3 23 48
  4. Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype? (PMID: 16014697) Tessier M.C. … Polychronakos C. (J. Med. Genet. 2006) 3 23 48
  5. OAS1 gene haplotype confers susceptibility to multiple sclerosis. (PMID: 17092260) Fedetz M. … Alcina A. (Tissue Antigens 2006) 3 23 48

Products for OAS1 Gene

Sources for OAS1 Gene

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