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Aliases for OARD1 Gene

Aliases for OARD1 Gene

  • O-Acyl-ADP-Ribose Deacylase 1 2 3 5
  • Terminal ADP-Ribose Protein Glycohydrolase 1 2 3
  • C6orf130 3 4
  • O-Acetyl-ADP-Ribose Deacetylase C6orf130 3
  • Chromosome 6 Open Reading Frame 130 2
  • EC 3.5.1.- 4
  • DJ34B21.3 3
  • TARG1 3

External Ids for OARD1 Gene

Previous HGNC Symbols for OARD1 Gene

  • C6orf130

Summaries for OARD1 Gene

GeneCards Summary for OARD1 Gene

OARD1 (O-Acyl-ADP-Ribose Deacylase 1) is a Protein Coding gene. GO annotations related to this gene include deacetylase activity and purine nucleoside binding.

UniProtKB/Swiss-Prot for OARD1 Gene

  • Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OARD1 Gene

Genomics for OARD1 Gene

Regulatory Elements for OARD1 Gene

Enhancers for OARD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OARD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OARD1 Gene

Chromosome:
6
Start:
41,033,627 bp from pter
End:
41,097,787 bp from pter
Size:
64,161 bases
Orientation:
Minus strand

Genomic View for OARD1 Gene

Genes around OARD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OARD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OARD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OARD1 Gene

Proteins for OARD1 Gene

  • Protein details for OARD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y530-OARD1_HUMAN
    Recommended name:
    O-acetyl-ADP-ribose deacetylase 1
    Protein Accession:
    Q9Y530
    Secondary Accessions:
    • A6NEK4
    • A8K4H4
    • Q96F23

    Protein attributes for OARD1 Gene

    Size:
    152 amino acids
    Molecular mass:
    17025 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OARD1 Gene

neXtProt entry for OARD1 Gene

Proteomics data for OARD1 Gene at MOPED

Post-translational modifications for OARD1 Gene

  • Ubiquitination at Lys 104
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OARD1 Gene

Domains & Families for OARD1 Gene

Protein Domains for OARD1 Gene

Suggested Antigen Peptide Sequences for OARD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y530

UniProtKB/Swiss-Prot:

OARD1_HUMAN :
  • Contains 1 Macro domain.
Domain:
  • Contains 1 Macro domain.
genes like me logo Genes that share domains with OARD1: view

No data available for Gene Families for OARD1 Gene

Function for OARD1 Gene

Molecular function for OARD1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=182 uM for O-acetyl-ADP-ribose {ECO:0000269 PubMed:21849506};
UniProtKB/Swiss-Prot EnzymeRegulation:
Subject to competitive inhibition by the product ADP-ribose.
UniProtKB/Swiss-Prot Function:
Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively.

Enzyme Numbers (IUBMB) for OARD1 Gene

Gene Ontology (GO) - Molecular Function for OARD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23481255
genes like me logo Genes that share ontologies with OARD1: view
genes like me logo Genes that share phenotypes with OARD1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OARD1 Gene

Localization for OARD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OARD1 Gene COMPARTMENTS Subcellular localization image for OARD1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OARD1 Gene

Pathways & Interactions for OARD1 Gene

SuperPathways for OARD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OARD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OARD1 Gene

Drugs & Compounds for OARD1 Gene

No Compound Related Data Available

Transcripts for OARD1 Gene

Unigene Clusters for OARD1 Gene

O-acyl-ADP-ribose deacylase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OARD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11: - -

Relevant External Links for OARD1 Gene

GeneLoc Exon Structure for
OARD1
ECgene alternative splicing isoforms for
OARD1

Expression for OARD1 Gene

mRNA expression in normal human tissues for OARD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OARD1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OARD1 Gene



SOURCE GeneReport for Unigene cluster for OARD1 Gene Hs.227457

genes like me logo Genes that share expression patterns with OARD1: view

Protein tissue co-expression partners for OARD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OARD1 Gene

Orthologs for OARD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OARD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OARD1 35
  • 91.45 (n)
  • 94.74 (a)
OARD1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf130 35
  • 94.08 (n)
  • 96.71 (a)
OARD1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oard1 35
  • 91.23 (n)
  • 95.39 (a)
Oard1 16
Oard1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf130 35
  • 99.78 (n)
  • 100 (a)
OARD1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OARD1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OARD1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C26H6ORF130 35
  • 74.22 (n)
  • 78.67 (a)
C26H6ORF130 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OARD1 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii oard1 35
  • 61.97 (n)
  • 64.08 (a)
oard1 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1173 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002604 35
  • 56.14 (n)
  • 55.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33054 35
  • 56.83 (n)
  • 55.4 (a)
CG33054 36
  • 45 (a)
OneToMany
CG33056 36
  • 19 (a)
OneToMany
CG34261 36
  • 47 (a)
OneToMany
Species with no ortholog for OARD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OARD1 Gene

ENSEMBL:
Gene Tree for OARD1 (if available)
TreeFam:
Gene Tree for OARD1 (if available)

Paralogs for OARD1 Gene

(1) SIMAP similar genes for OARD1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with OARD1: view

No data available for Paralogs for OARD1 Gene

Variants for OARD1 Gene

Sequence variations from dbSNP and Humsavar for OARD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1060042 -- 41,066,852(-) AAATT(C/T)TACAT utr-variant-3-prime
rs11280 -- 41,067,119(-) AAAGT(A/G)AGGAG utr-variant-3-prime
rs11556586 -- 41,066,703(-) AAGGG(A/T)CCAAG downstream-variant-500B
rs7341340 -- 41,069,123(+) GAGAC(C/T)TTCAA intron-variant
rs7738684 -- 41,070,813(+) GAAGA(A/G)AAAGC intron-variant

Variation tolerance for OARD1 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OARD1 Gene

HapMap Linkage Disequilibrium report
OARD1
Human Gene Mutation Database (HGMD)
OARD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OARD1 Gene

Disorders for OARD1 Gene

Relevant External Links for OARD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OARD1

No disorders were found for OARD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OARD1 Gene

Publications for OARD1 Gene

  1. Orphan macrodomain (human C6ORF130) is an o-acyl-ADP-ribose deacylase: solution structure and catalytic properties. (PMID: 21849506) Peterson F.C. … Volkman B.F. (J. Biol. Chem. 2011) 2 3 4 67
  2. Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation. (PMID: 26091342) Barkauskaite E. … Ahel I. (Mol. Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. (PMID: 23481255) Sharifi R. … Ahel I. (EMBO J. 2013) 3

Products for OARD1 Gene

Sources for OARD1 Gene

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