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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OAF Gene

protein-coding GIFtS: 43
GCID: GC11P120081

OAF homolog (Drosophila)

Explore 4 diseases affiliated with
OAF via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
OAF Homolog (Drosophila)¹ ²
NS5ATP13TP2² ³
HCV NS5A-Transactivated Protein 13 Target Protein 2² ³
MGC52117¹
Out At First Protein Homolog²

External Ids:	HGNC: 28752¹	Entrez Gene: 220323²	Ensembl: ENSG00000184232⁷	UniProtKB: Q86UD1³

Export aliases for OAF gene to outside databases

Previous GC identifers: GC11P119587 GC11P116021

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OAF gene promoter:
AML1a HNF-3beta Ik-3 RORalpha2 PPAR-alpha AREB6 POU2F1 POU2F1a FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OAF promoter sequence

Search SABiosciences Chromatin IP Primers for OAF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OAF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

OAF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAF gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P120081: view genomic region (about GC identifiers)

Start:	120,081,475 bp from pter	End:	120,101,001 bp from pter
Size:	19,527 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OAF_HUMAN, Q86UD1 (See protein sequence)

Recommended Name: Out at first protein homolog precursor

Size: 273 amino acids; 30688 Da

Explore the universe of human proteins at neXtProt for OAF: NX_Q86UD1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86UD1

OAF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_848602.1

ENSEMBL proteins:

ENSP00000332613 ENSP00000431865

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OAF for domains About GeneDecksing

1 InterPro domain/family:

IPR026315 Oaf

Graphical View of Domain Structure for InterPro Entry Q86UD1

ProtoNet protein and cluster: Q86UD1

UniProtKB/Swiss-Prot: OAF_HUMAN, Q86UD1

Similarity: Belongs to the OAF family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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3 GenomeRNAi human phenotypes for OAF:

G2 arrest

Increased G2M DNA content

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OAF

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for OAF gene:

NM_178507.2

Unigene Cluster for OAF:

OAF homolog (Drosophila)

Hs.445081 [show with all ESTs]

Unigene Representative Sequence: BC047726

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000328965(uc001pxb.3) ENST00000531220 ENST00000534735

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Additional cDNA sequence:

AK021720.1 AY459296.1 BC047726.1

11 DOTS entries:

DT.95113993 DT.112735 DT.120746885 DT.120746972 DT.95113989 DT.100783971 DT.100739501 DT.120746898

DT.91758611 DT.96086312 DT.91904293

24/172 AceView cDNA sequences (see all 172):

AA317315 BE677599 CA420752 CR606518 NM_178507 CR609690 CD675070 BX394807

BG033561 AI537268 CR600676 AY459296 CR610860 CR617263 BC047726 BU681607

CR603084 CR617508 BG036222 AW272308 AI886774 AA581519 AI818480 CK724948

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for OAF About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6
SP1:					-		-
SP2:					-		-		-
SP3:

ECgene alternative splicing isoforms for OAF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OAF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTACGAGG

About this image

OAF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OAF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OAF

SOURCE GeneReport for Unigene cluster: Hs.445081

SABiosciences Custom PCR Arrays for OAF

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for OAF gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Oaf^{1 , 5}	OAF homolog (Drosophila)^{1, 5}	85.68(n)¹ 87.78(a)¹		9 (24.24 cM)⁵ 102644¹ NM_178644.3¹ NP_848759.1¹ 43221278⁵
chicken (Gallus gallus)	Aves	OAF¹	OAF homolog (Drosophila)	77.44(n) 73.31(a)		395161 NM_204500.1 NP_989831.1
lizard (Anolis carolinensis)	Reptilia	OAF⁶	--	68(a)	1 ↔ 1	LGa(1194572-1224719)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.2508²	Transcribed sequence with weak similarity to protein more	75.72(n)		AL900016.2
zebrafish (Danio rerio)	Actinopterygii	oafa¹	OAF homolog a (Drosophila)	66.8(n) 59.84(a)		571744 XM_695363.5 XP_700455.3
fruit fly (Drosophila melanogaster)	Insecta	oaf¹	out at first	55.9(n) 40.77(a)		33435 NM_175949.1 NP_787963.2

ENSEMBL Gene Tree for OAF (if available)
TreeFam Gene Tree for OAF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs477863^1,2	C,F,O,H,	--	120079884(-)	`ACATCA/CGGGAG`	1	--	us2k¹		29		NS EA NA WA CSA	2774
rs191120986^1,2		--	120079906(+)	`CCTTAG/TGAGCC`	1	--	us2k¹		0	--	--	--	--
rs138581112^1,2		--	120079955(+)	`TATGT-/TTTTG TTTTG`	1	--	us2k¹		0	--	--	--	--
rs476809^1,2	C,A,H,	--	120080022(-)	`CACTGC/AACTCC`	1	--	us2k¹		9		MN NA WA CSA	198
rs183783833^1,2		--	120080029(+)	`AGTGGC/TGCAAT`	1	--	us2k¹		0	--	--	--	--
rs146933298^1,2		--	120080063(+)	`TCCTGG/TGTTCA`	1	--	us2k¹		0	--	--	--	--
rs188366563^1,2		--	120080095(+)	`TCCCGA/GGTAGC`	1	--	us2k¹		0	--	--	--	--
rs137948180^1,2		--	120080159(+)	`AGAGAC/TGGGAT`	1	--	us2k¹		0	--	--	--	--
rs141957777^1,2		--	120080176(+)	`TTGTTC/GCCCAG`	1	--	us2k¹		0	--	--	--	--
rs192471544^1,2		--	120080404(+)	`GATTCA/GGGAAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for OAF (120081475 - 120101001 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OAF: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OAF for disorders About GeneDecksing

4 diseases for OAF: About MalaCards

glottis carcinoma hypercalcemia myeloma carcinoma

2 diseases from the University of Copenhagen DISEASES database for OAF:

Glottis carcinoma Sinusitis

Export disorders for OAF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OAF gene integrated from 9 sources:
(articles sorted by number of sources associating them with OAF)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 220323	HGNC: 28752	AceView: NS5ATP13TP2	Ensembl:ENSG00000184232	euGenes: HUgn220323
ECgene: OAF	H-InvDB: OAF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OAF	Pharmacogenomics, SNPs, Pathways

Intellectual Property for OAF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OAF gene:
Search GeneIP for patents involving OAF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAF

	SwitchGear 3'UTR luciferase reporter plasmids for OAF
	SwitchGear Promoter luciferase reporter plasmids for OAF

Search ThermoFisher Antibodies for OAF

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OAF

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OAF gene at Home site.

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OAF Gene

OAF homolog (Drosophila)

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Export list of displayed genes

OAF Gene

OAF homolog (Drosophila)

Aliasesfor OAF gene

Summariesfor OAF gene

Genomic Viewsfor OAF gene

Proteinsfor OAF gene

Protein Domains /Familiesfor OAF gene

Functionfor OAF gene

Pathways & Interactionsfor OAF gene

Drugs & Compoundsfor OAF gene

Transcriptsfor OAF gene

Expression for OAF gene

Orthologsfor OAF gene

Paralogsfor OAF gene

Genomic Variantsfor OAF gene

Disorders / Diseasesfor OAF gene

Publicationsfor OAF gene

External Searches for OAF gene

Genome Databases showing OAF gene

Other Databases showing OAF gene

Specialized Databases showing OAF gene

Intellectual Propertyfor OAF gene

Productsfor OAF gene

View Random Gene

Aliases
for OAF gene

Summaries
for OAF gene

Genomic Views
for OAF gene

Proteins
for OAF gene

Protein Domains /
Families
for OAF gene

Function
for OAF gene

Pathways & Interactions
for OAF gene

Drugs & Compounds
for OAF gene

Transcripts
for OAF gene

Expression
for OAF gene

Orthologs
for OAF gene

Paralogs
for OAF gene

Genomic Variants
for OAF gene

Disorders / Diseases
for OAF gene

Publications
for OAF gene

Intellectual Property
for OAF gene

Products
for OAF gene