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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OAF Gene

protein-coding   GIFtS: 45
GCID: GC11P120081

OAF Homolog (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
OAF Homolog (Drosophila)1 2
NS5ATP13TP22 3
HCV NS5A-Transactivated Protein 13 Target Protein 22 3
Out At First Protein Homolog2

External Ids:    HGNC: 287521   Entrez Gene: 2203232   Ensembl: ENSG000001842327   UniProtKB: Q86UD13   

Export aliases for OAF gene to outside databases

Previous GC identifers: GC11P119587 GC11P116021


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OAF Gene: 
OAF (OAF homolog (Drosophila)) is a protein-coding gene. Diseases associated with OAF include glottis carcinoma, and hypercalcemia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OAF gene promoter:
         AML1a   HNF-3beta   Ik-3   RORalpha2   PPAR-alpha   AREB6   POU2F1   POU2F1a   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOAF promoter sequence
   Search SABiosciences Chromatin IP Primers for OAF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OAF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

OAF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OAF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P120081:  view genomic region     (about GC identifiers)

Start:
120,081,475 bp from pter      End:
120,101,041 bp from pter
Size:
19,567 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OAF_HUMAN, Q86UD1 (See protein sequence)
Recommended Name: Out at first protein homolog precursor  
Size: 273 amino acids; 30688 Da

Explore the universe of human proteins at neXtProt for OAF: NX_Q86UD1

Explore proteomics data for OAF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UD1

  • OAF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OAF Protein Expression
    REFSEQ proteins: NP_848602.1  
    ENSEMBL proteins: 
     ENSP00000332613   ENSP00000431865  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026315 Oaf

    Graphical View of Domain Structure for InterPro Entry Q86UD1

    ProtoNet protein and cluster: Q86UD1

    UniProtKB/Swiss-Prot: OAF_HUMAN, Q86UD1
    Similarity: Belongs to the OAF family


    OAF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         3 GenomeRNAi human phenotypes for OAF:
     G2 arrest  Increased G2M DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OAF 
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    SwitchGear 3'UTR luciferase reporter plasmidOAF 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OAF

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OAF

    Search CenterWatch for drugs/clinical trials and news about OAF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OAF gene: 
    NM_178507.2  

    Unigene Cluster for OAF:

    OAF homolog (Drosophila)
    Hs.445081  [show with all ESTs]
    Unigene Representative Sequence: BC047726
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328965(uc001pxb.3) ENST00000531220 ENST00000534735
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidOAF 3' UTR sequence
    Inhib. RNA
    Products:
         
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                         Customized lentivirus expression plasmids for stable overexpression of OAF 
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    Additional mRNA sequence: 

    AK021720.1 AY459296.1 BC047726.1 

    11 DOTS entries:

    DT.95113993  DT.112735  DT.120746885  DT.120746972  DT.95113989  DT.100783971  DT.100739501  DT.120746898 
    DT.91758611  DT.96086312  DT.91904293 

    24/172 AceView cDNA sequences (see all 172):

    CA420752 BG033561 CR603084 CR606518 AI537268 NM_178507 BC047726 CD675070 
    BX394807 CR610860 AY459296 CR600676 CR617508 BU681607 CR609690 AA317315 
    BE677599 CR617263 AL578642 BX436563 AW474541 BU631085 AL556363 CK724948 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for OAF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
    SP1:              -     -                           
    SP2:              -     -     -                     
    SP3:                                                


    ECgene alternative splicing isoforms for OAF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OAF expression in normal human tissues (normalized intensities)      OAF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTACGAGG
    OAF Expression
    About this image


    OAF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Liver (Hepatobiliary System)

    See OAF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OAF

    SOURCE GeneReport for Unigene cluster: Hs.445081
        SABiosciences Custom PCR Arrays for OAF
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OAF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OAF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OAF gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oaf1 , 5 OAF homolog (Drosophila)1, 5 85.68(n)1
    87.78(a)1
      9 (24.24 cM)5
    1026441  NM_178644.31  NP_848759.11 
     432212785 
    chicken
    (Gallus gallus)
    Aves OAF1 OAF homolog (Drosophila) 77.44(n)
    73.31(a)
      395161  NM_204500.1  NP_989831.1 
    lizard
    (Anolis carolinensis)
    Reptilia OAF6
    Uncharacterized protein
    68(a)
    1 ↔ 1
    LGa(1194413-1224725)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.25082 Transcribed sequence with weak similarity to protein more 75.72(n)    AL900016.2 
    zebrafish
    (Danio rerio)
    Actinopterygii oafa1 OAF homolog a (Drosophila) 66.8(n)
    59.84(a)
      571744  XM_695363.5  XP_700455.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta oaf1 out at first 55.9(n)
    40.77(a)
      33435  NM_175949.1  NP_787963.2 


    ENSEMBL Gene Tree for OAF (if available)
    TreeFam Gene Tree for OAF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/508 SNPs in OAF are shown (see all 508)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1513313981,2
    C--119945668(+) ATCCAC/GCATCC 1 -- us2k10--------
    rs4778631,2
    C,F,O,H--120079884(-) ACATCA/CGGGAG 1 -- us2k129Minor allele frequency- C:0.14NS EA NA WA CSA 2774
    rs1911209861,2
    --120079906(+) CCTTAG/TGAGCC 1 -- us2k10--------
    rs3728270351,2
    C--120079954(+) TATGT-/TTTTG/T
    TTTGTTTTG
    TTTTG
    1 -- us2k10--------
    rs1385811121,2
    --120079955(+) TATGT-/TTTTG 
            
    TTTTG
    1 -- us2k10--------
    rs4768091,2
    C,A,H--120080022(-) CACTGC/AACTCC 1 -- us2k19Minor allele frequency- A:0.18MN NA WA CSA 198
    rs1837838331,2
    C--120080029(+) AGTGGC/TGCAAT 1 -- us2k10--------
    rs1469332981,2
    C--120080063(+) TCCTGG/TGTTCA 1 -- us2k10--------
    rs1883665631,2
    --120080095(+) TCCCGA/GGTAGC 1 -- us2k10--------
    rs1379481801,2
    C--120080159(+) AGAGAC/TGGGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OAF (120081475 - 120101041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OAF:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745145CNV Deletion23290073
    esv2745144CNV Deletion23290073
    nsv518CNV Insertion18451855
    nsv518464CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for OAF:    About MalaCards
    glottis carcinoma    hypercalcemia    sinusitis

    2 diseases from the University of Copenhagen DISEASES database for OAF:
    Glottis carcinoma     Sinusitis

    OAF for disorders           About GeneDecksing


    Export disorders for OAF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OAF gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OAF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 220323 HGNC: 28752 AceView: NS5ATP13TP2 Ensembl:ENSG00000184232 euGenes: HUgn220323
    ECgene: OAF H-InvDB: OAF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OAF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OAF gene:
    Search GeneIP for patents involving OAF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for OAF
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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