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Aliases for OAF Gene

Aliases for OAF Gene

  • Out At First Homolog 2 3 5
  • HCV NS5A-Transactivated Protein 13 Target Protein 2 3 4
  • NS5ATP13TP2 3 4
  • OAF Homolog (Drosophila) 2
  • OAF Homolog 3

External Ids for OAF Gene

Previous GeneCards Identifiers for OAF Gene

  • GC11P119587
  • GC11P120081
  • GC11P116021

Summaries for OAF Gene

GeneCards Summary for OAF Gene

OAF (Out At First Homolog) is a Protein Coding gene. Diseases associated with OAF include Chronic Maxillary Sinusitis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAF Gene

Genomics for OAF Gene

Regulatory Elements for OAF Gene

Enhancers for OAF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OAF on UCSC Golden Path with GeneCards custom track

Promoters for OAF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OAF on UCSC Golden Path with GeneCards custom track

Genomic Location for OAF Gene

120,210,767 bp from pter
120,230,332 bp from pter
19,566 bases
Plus strand

Genomic View for OAF Gene

Genes around OAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAF Gene

Proteins for OAF Gene

  • Protein details for OAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Out at first protein homolog
    Protein Accession:

    Protein attributes for OAF Gene

    273 amino acids
    Molecular mass:
    30688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OAF Gene

Proteomics data for OAF Gene at MOPED

Post-translational modifications for OAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OAF Gene

Domains & Families for OAF Gene

Protein Domains for OAF Gene


Suggested Antigen Peptide Sequences for OAF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the OAF family.
  • Belongs to the OAF family.
genes like me logo Genes that share domains with OAF: view

No data available for Gene Families for OAF Gene

Function for OAF Gene

genes like me logo Genes that share phenotypes with OAF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OAF

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OAF Gene

Localization for OAF Gene

Subcellular locations from

Jensen Localization Image for OAF Gene COMPARTMENTS Subcellular localization image for OAF gene
Compartment Confidence
extracellular 5
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for OAF Gene

Pathways & Interactions for OAF Gene

SuperPathways for OAF Gene

No Data Available

Interacting Proteins for OAF Gene

Gene Ontology (GO) - Biological Process for OAF Gene


No data available for Pathways by source and SIGNOR curated interactions for OAF Gene

Drugs & Compounds for OAF Gene

No Compound Related Data Available

Transcripts for OAF Gene

mRNA/cDNA for OAF Gene

Unigene Clusters for OAF Gene

OAF homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OAF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - - -

Relevant External Links for OAF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OAF Gene

mRNA expression in normal human tissues for OAF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAF Gene

This gene is overexpressed in Liver (x9.4).

Protein differential expression in normal tissues from HIPED for OAF Gene

This gene is overexpressed in Serum (35.6) and Vitreous humor (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for OAF Gene

SOURCE GeneReport for Unigene cluster for OAF Gene Hs.445081

genes like me logo Genes that share expression patterns with OAF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OAF Gene

Orthologs for OAF Gene

This gene was present in the common ancestor of animals.

Orthologs for OAF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OAF 35
  • 91.74 (n)
  • 91.32 (a)
OAF 36
  • 85 (a)
(Canis familiaris)
Mammalia OAF 35
  • 89.39 (n)
  • 89.9 (a)
OAF 36
  • 74 (a)
(Mus musculus)
Mammalia Oaf 35
  • 86.04 (n)
  • 88.62 (a)
Oaf 16
Oaf 36
  • 83 (a)
(Pan troglodytes)
Mammalia OAF 35
  • 99.15 (n)
  • 98.9 (a)
OAF 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Oaf 35
  • 86.26 (n)
  • 88.16 (a)
(Monodelphis domestica)
Mammalia OAF 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 73 (a)
(Gallus gallus)
Aves OAF 35
  • 78.64 (n)
  • 73.88 (a)
OAF 36
  • 69 (a)
(Anolis carolinensis)
Reptilia OAF 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia oaf 35
  • 68.06 (n)
  • 68.75 (a)
Str.2508 35
(Danio rerio)
Actinopterygii oafa 35
  • 68.32 (n)
  • 61.57 (a)
OAF (2 of 2) 36
  • 50 (a)
oafa 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008944 35
  • 52.63 (n)
  • 40.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta oaf 35
  • 57.26 (n)
  • 41.91 (a)
oaf 36
  • 31 (a)
Species with no ortholog for OAF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OAF Gene

Gene Tree for OAF (if available)
Gene Tree for OAF (if available)

Paralogs for OAF Gene

No data available for Paralogs for OAF Gene

Variants for OAF Gene

Sequence variations from dbSNP and Humsavar for OAF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2508489 - 120,228,949(+) GGACC(A/G)CGGGA reference, missense
rs2508490 - 120,228,970(+) CTGCC(A/G)CTATG reference, missense
rs521841 -- 120,209,818(+) GGTAG(A/C)GGGAA upstream-variant-2KB
rs531698 -- 120,217,249(-) CCAAG(A/G)GGCCA intron-variant
rs541857 -- 120,214,761(-) TTGAC(A/G)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OAF Gene

Variant ID Type Subtype PubMed ID
nsv518464 CNV Loss 19592680
nsv518 CNV Insertion 18451855
esv2745144 CNV Deletion 23290073
esv2745145 CNV Deletion 23290073

Variation tolerance for OAF Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OAF Gene

Disorders for OAF Gene

MalaCards: The human disease database

(1) MalaCards diseases for OAF Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic maxillary sinusitis
  • chronic antritis
- elite association - COSMIC cancer census association via MalaCards
Search OAF in MalaCards View complete list of genes associated with diseases

Relevant External Links for OAF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with OAF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OAF Gene

Publications for OAF Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for OAF Gene

Sources for OAF Gene