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OAF Gene

protein-coding GIFtS: 40

GC11P119587

OAF homolog (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC52117 ^¹, ²
NS5ATP13TP2 ^², ³

Descriptions
HCV NS5A-transactivated protein 13 target protein 2 ^³
OAF homolog ^²
OAF homolog (Drosophila) ^²

External Ids
HGNC: 28752¹
Entrez Gene: 220323²
UniProtKB: Q86UD1³
Ensembl: ENSG00000184232⁷

Search outside databases for aliases for OAF gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the OAF gene

Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3

OAF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P119587: (about GC identifiers)

Start:	119,586,957 bp from pter
End:	119,605,860 bp from pter
Size:	18,904 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OAF_HUMAN, Q86UD1 (See protein sequence)

Recommended Name: Out at first protein homolog precursor

Size: 273 amino acids; 30688 Da

REFSEQ proteins: NP_848602.1

ENSEMBL proteins:

ENSP00000332613

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for OAF:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for OAF

Assays for OAF:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q86UD1

UniProtKB/Swiss-Prot: OAF_HUMAN, Q86UD1

Similarity: Belongs to the OAF family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OAF)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178507

Applied Biosystems Silencer® siRNAs for OAF

Sigma-Aldrich siRNA for OAF

Sigma-Aldrich shRNA for OAF

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_178507
Myc/DDK tagged cDNA clone in CMV expression vector: NM_178507
untagged cDNA clones in CMV expression vector (see all 2): NM_178507

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_178507

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Interacting proteins for OAF (ENSP00000332613³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL1B	ENSP00000263341³	STRING (score=.718)
ENSG00000173503	ENSP00000372991³	STRING (score=.716)
ENSG00000204496	ENSP00000365303³	STRING (score=.716)
PTH	ENSP00000282091³	STRING (score=.7)
--	ENSP00000372793³	STRING (score=.716)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for OAF

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (OAF)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178507

Sigma-Aldrich siRNA for OAF

Sigma-Aldrich shRNA for OAF

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_178507

REFSEQ mRNAs for OAF gene:

NM_178507.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_178507

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178507
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178507
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_178507

Additional cDNA sequence:

AK021720.1 AY459296.1 BC047726.1 CR600676.1 CR603084.1 CR606518.1 CR609690.1 CR610860.1

CR617263.1 CR617508.1

12 DOTS entries:

DT.95113993 DT.112735 DT.120746885 DT.120746972 DT.100739501 DT.95113989 DT.100783971 DT.120746898

DT.307659 DT.91758611 DT.91904293 DT.96086312

24/172 AceView cDNA sequences (see all 172 ):

CA420752 BG033561 CR617263 BU681607 AA317315 CR600676 BE677599 CR603084

CR617508 CR610860 CR606518 CR609690 BC047726 NM_178507 BX394807 AY459296

CD675070 AI537268 BM464380 AI086432 AL527913 BQ002411 AW473632 AI886774

highest scoring ESTs for OAF:

AI887362 AA142849 AA305475 AA317315 AA375759 AA452927 AA581519 AA582152 AA582243 AA745715

Unigene Cluster for OAF:

OAF homolog (Drosophila)

Hs.445081 [show with all ESTs]

Unigene Representative Sequence: BC047726

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for OAF

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6
SP1:					-		-
SP2:					-		-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for OAF

1 Ensembl transcript including schematic representation:

ENST00000328965

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OAF expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for OAF

¹ / ² / ³

5 probe-sets matching OAF gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
63838_at²^{, 3}	U95-C	1	0.56	1.00	1.00	1.00	AI887362	1.00	1.00	1.00	1
225510_at²^{, 3}	U133-B	2	1.00	0.95	--	--	BG033561	0.80	1.00	0.91	1
228939_at*²^{, 3}	U133-B	1	1.00	1.00	--	--	AU145346	0.40	1.00	0.76	1
225510_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
228939_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGTACGAGG

SOURCE GeneReport for Unigene cluster: Hs.445081

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OAF gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OAF¹	--	OAF homolog (Drosophila)	90.21(n) 91.24(a)	489361 XM_546479.2 XP_546479.2
chimpanzee (Pan troglodytes)	OAF¹	--	OAF homolog (Drosophila)	99.15(n) 98.9(a)	744430 XM_001166728.1 XP_001166728.1
cow (Bos taurus)	OAF¹	--	OAF homolog (Drosophila)	90.82(n) 90.57(a)	514557 XM_592427.3 XP_592427.2
rat (Rattus norvegicus)	Oaf¹	--	OAF homolog (Drosophila)	85.68(n) 87.04(a)	315594 NM_001014090.1 NP_001014112.1
mouse (Mus musculus)	Oaf^{1, 5}	9 (23.00 cM)⁵	OAF homolog (Drosophila)^{1, 5}	85.68(n)¹ 87.78(a)¹	102644¹ NM_178644.3¹ NP_848759.1¹ AI132668⁵ AK051349⁵ (see all 14)

About this table Species with no ortholog for OAF

ENSEMBL Gene Tree for OAF

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/131 NCBI SNPs in OAF are shown (see all 131 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 71)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2845705^1,2	A,C,F,H,O	119606302(+)	`CTGTTA/TGCCAT`	1	--	ng3¹		8		EU EA WA	832
	rs580174^1,2	A,C,F,H	119606077(+)	`ACATAA/GCTGCA`	1	--	ng3¹		10		NS MN EU EA WA	808
	rs9655^1,2	A,C,F,H	119605807(+)	`TTTTAA/GTGCAA`	1	--	ut3¹ ese³		19		NS MN EA NA EU WA	1418
	rs2508490^1,2	A,C,F,H	119604889(+)	`CTGCCG/ACTATG`	1	H/R	mis¹ ese³		5		EA EU WA	1918
	rs477863^1,2	C,F,H,O	119585094(-)	`ACATCA/CGGGAG`	1	--	ng5¹		8		EU EA WA	832
	rs3225^1,2	A,C,F,H	119605730(+)	`CTCTAC/GACAGA`	1	--	ut3¹ ese³		6		MN EU EA WA	790
--	rs476809^1,2	A,C,F	119585232(-)	`cactgC/Aactcc`	1	--	ng5¹		1		MN	184
	rs2508489^1,2	A,C,F	119604868(+)	`GGACCA/GCGGGA`	1	H/R	mis¹ ese³		1		EA	1474
	rs521841^1,2	A,C	119585736(+)	`GGTAGA/CGGGAA`	1	--	ng5¹		0	--	--	--	--
	rs14862^1,2	F	119605656(-)	`GTGATC/ATGTCT`	1	--	ut3¹ ese³		1		MN	184

About this table

HapMap Linkage Disequilibrium images for OAF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for OAF gene:

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 220323	HGNC: 28752	AceView: NS5ATP13TP2	Ensembl:ENSG00000184232	euGenes: HUgn220323
ECgene: OAF	H-InvDB: OAF

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for OAF
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for OAF:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for OAF-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OAF		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for OAF		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for OAF

Search Tocris compounds for OAF

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for OAF

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OAF Gene at Home site.
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OAF Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for OAF

Summaries
for OAF

Genomic Location
for OAF

Proteins
for OAF

Protein Domains/
Families
for OAF

Gene Function
for OAF

Pathways & Interactions
for OAF

Drugs & Compounds
for OAF

Transcripts
for OAF

Expression
for OAF

Orthologs
for OAF

Paralogs
for OAF

SNPs/Variants
for OAF

Disorders & Mutations
for OAF

Medical News
for OAF

Publications
for OAF

Search for OAF

Genome Databases showing OAF

Other Databases showing OAF

Specialized Databases showing OAF

Licensable Technologies
for OAF

Services
for OAF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

OAF Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor OAF

Summariesfor OAF

Genomic Locationfor OAF

Proteinsfor OAF

Protein Domains/Familiesfor OAF

Gene Functionfor OAF

Pathways & Interactionsfor OAF

Drugs & Compoundsfor OAF

Transcriptsfor OAF

Expression for OAF

Orthologsfor OAF

Paralogsfor OAF

SNPs/Variantsfor OAF

Disorders & Mutationsfor OAF

Medical Newsfor OAF

Publicationsfor OAF

Search for OAF

Genome Databases showing OAF

Other Databases showing OAF

Specialized Databases showing OAF

Licensable Technologiesfor OAF

Servicesfor OAF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for OAF

Summaries
for OAF

Genomic Location
for OAF

Proteins
for OAF

Protein Domains/
Families
for OAF

Gene Function
for OAF

Pathways & Interactions
for OAF

Drugs & Compounds
for OAF

Transcripts
for OAF

Expression
for OAF

Orthologs
for OAF

Paralogs
for OAF

SNPs/Variants
for OAF

Disorders & Mutations
for OAF

Medical News
for OAF

Publications
for OAF

Licensable Technologies
for OAF

Services
for OAF