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Aliases for OAF Gene

Aliases for OAF Gene

  • Out At First Homolog 2 3 5
  • HCV NS5A-Transactivated Protein 13 Target Protein 2 3 4
  • NS5ATP13TP2 3 4
  • Out At First Protein Homolog 3
  • OAF Homolog (Drosophila) 2
  • OAF Homolog 3

External Ids for OAF Gene

Previous GeneCards Identifiers for OAF Gene

  • GC11P119587
  • GC11P120081
  • GC11P116021

Summaries for OAF Gene

GeneCards Summary for OAF Gene

OAF (Out At First Homolog) is a Protein Coding gene. Diseases associated with OAF include Chronic Maxillary Sinusitis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OAF Gene

Genomics for OAF Gene

Regulatory Elements for OAF Gene

Enhancers for OAF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F120181 0.8 Ensembl ENCODE 18.1 -24.4 -24424 9.0 HDGF WRNIP1 ZFP64 ARID4B DMAP1 ZNF48 YY1 ZNF143 FOS ZNF263 OAF POU2F3 TRIM29 LOC729173 LOC105369530
GH11F120180 0.9 Ensembl ENCODE 15.8 -30.0 -29967 1.2 CTCF ZNF341 SMC3 FOS RAD21 NFE2L2 OAF TRIM29 LOC729173
GH11F120195 0.2 ENCODE 15.4 -11.7 -11743 7.4 PKNOX1 ZFP64 ARID4B FEZF1 DMAP1 TBX21 KAT8 ZSCAN16 SMARCA4 GLIS1 OAF LOC729173 TMEM136 TRIM29 LOC105369530
GH11F120168 0.7 ENCODE 14.9 -41.6 -41559 1.0 CTCF SAP130 HINFP TEAD4 ARID4B ZNF48 RAD21 ZFHX2 POLR2A EGR1 OAF LOC729173 TRIM29
GH11F120207 0.9 FANTOM5 ENCODE 11 +0.4 402 6.9 CREB3L1 SIN3A ARID4B DMAP1 YY1 GLIS2 SP3 SP5 MIER2 REST POU2F3 TRIM29 LOC729173 OAF ARHGEF12 GRIK4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OAF on UCSC Golden Path with GeneCards custom track

Promoters for OAF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000570024 833 2801 SIN3A ARID4B ZSCAN9 RAD21 GLIS2 HCFC1 REST TGIF2 TFDP1 RCOR2

Genomic Location for OAF Gene

Chromosome:
11
Start:
120,210,767 bp from pter
End:
120,230,332 bp from pter
Size:
19,566 bases
Orientation:
Plus strand

Genomic View for OAF Gene

Genes around OAF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OAF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OAF Gene

Proteins for OAF Gene

  • Protein details for OAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UD1-OAF_HUMAN
    Recommended name:
    Out at first protein homolog
    Protein Accession:
    Q86UD1

    Protein attributes for OAF Gene

    Size:
    273 amino acids
    Molecular mass:
    30688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OAF Gene

Post-translational modifications for OAF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OAF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OAF Gene

Domains & Families for OAF Gene

Protein Domains for OAF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OAF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UD1

UniProtKB/Swiss-Prot:

OAF_HUMAN :
  • Belongs to the OAF family.
Family:
  • Belongs to the OAF family.
genes like me logo Genes that share domains with OAF: view

No data available for Gene Families for OAF Gene

Function for OAF Gene

genes like me logo Genes that share phenotypes with OAF: view

Animal Models for OAF Gene

MGI Knock Outs for OAF:
  • Oaf tm1a(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for OAF

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OAF Gene

Localization for OAF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OAF Gene COMPARTMENTS Subcellular localization image for OAF gene
Compartment Confidence
extracellular 5
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for OAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with OAF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OAF Gene

Pathways & Interactions for OAF Gene

SuperPathways for OAF Gene

No Data Available

Interacting Proteins for OAF Gene

Gene Ontology (GO) - Biological Process for OAF Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OAF Gene

Transcripts for OAF Gene

mRNA/cDNA for OAF Gene

Unigene Clusters for OAF Gene

OAF homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OAF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:

Relevant External Links for OAF Gene

GeneLoc Exon Structure for
OAF
ECgene alternative splicing isoforms for
OAF

Expression for OAF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OAF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OAF Gene

This gene is overexpressed in Liver (x9.4).

Protein differential expression in normal tissues from HIPED for OAF Gene

This gene is overexpressed in Serum (35.6) and Vitreous humor (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OAF Gene



NURSA nuclear receptor signaling pathways regulating expression of OAF Gene:

OAF

SOURCE GeneReport for Unigene cluster for OAF Gene:

Hs.445081
genes like me logo Genes that share expression patterns with OAF: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OAF Gene

Orthologs for OAF Gene

This gene was present in the common ancestor of animals.

Orthologs for OAF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OAF 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia OAF 34 35
  • 91.74 (n)
dog
(Canis familiaris)
Mammalia OAF 34 35
  • 89.39 (n)
rat
(Rattus norvegicus)
Mammalia Oaf 34
  • 86.26 (n)
mouse
(Mus musculus)
Mammalia Oaf 34 16 35
  • 86.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OAF 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves OAF 34 35
  • 78.64 (n)
lizard
(Anolis carolinensis)
Reptilia OAF 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oaf 34
  • 68.06 (n)
Str.2508 34
zebrafish
(Danio rerio)
Actinopterygii oafa 34 35
  • 68.32 (n)
OAF (2 of 2) 35
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta oaf 34 35
  • 57.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008944 34
  • 52.63 (n)
Species where no ortholog for OAF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OAF Gene

ENSEMBL:
Gene Tree for OAF (if available)
TreeFam:
Gene Tree for OAF (if available)

Paralogs for OAF Gene

No data available for Paralogs for OAF Gene

Variants for OAF Gene

Sequence variations from dbSNP and Humsavar for OAF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1045849 -- 120,229,523(+) GACAC(A/C)CACCT utr-variant-3-prime
rs111273426 -- 120,222,635(+) GAGGC(C/T)GGGTG intron-variant
rs111332078 -- 120,212,263(+) GTGGG(-/TGGG)TGTGG intron-variant
rs111371593 -- 120,214,663(+) CAGCC(C/T)TTCCC intron-variant
rs111659217 -- 120,211,250(+) CGCGC(C/G)GGGGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for OAF Gene

Variant ID Type Subtype PubMed ID
esv2745144 CNV deletion 23290073
esv2745145 CNV deletion 23290073
nsv518 CNV insertion 18451855
nsv518464 CNV loss 19592680

Variation tolerance for OAF Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.43; 88.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OAF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OAF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OAF Gene

Disorders for OAF Gene

MalaCards: The human disease database

(1) MalaCards diseases for OAF Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic maxillary sinusitis
  • chronic antritis
- elite association - COSMIC cancer census association via MalaCards
Search OAF in MalaCards View complete list of genes associated with diseases

Relevant External Links for OAF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OAF
genes like me logo Genes that share disorders with OAF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OAF Gene

Publications for OAF Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for OAF Gene

Sources for OAF Gene

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