Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NYX Gene

protein-coding   GIFtS: 55
GCID: GC0XP041306

Nyctalopin


(Previous symbols: CSNB1, CSNB4)
  See NYX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
nyctalopin1 2     CSNB1A2 5
CSNB11 2     NBM12 5
CSNB41 2     Leucine-Rich Repeat Protein2
CLRP2 3     

External Ids:    HGNC: 80821   Entrez Gene: 605062   Ensembl: ENSG000001889377   OMIM: 3002785   UniProtKB: Q9GZU53   

Export aliases for NYX gene to outside databases

Previous GC identifers: GC0XP039333 GC0XP039555 GC0XP040151 GC0XP040337 GC0XP041062 GC0XP041191 GC0XP039038


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NYX Gene:
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this
gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital
stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired
scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests
that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading
to the visual losses seen in patients with complete CSNB. (provided by RefSeq, Oct 2008)

GeneCards Summary for NYX Gene:
NYX (nyctalopin) is a protein-coding gene. Diseases associated with NYX include nyx-related x-linked congenital stationary night blindness, and irregular astigmatism. An important paralog of this gene is LRRC53.

Gene Wiki entry for NYX (Nyctalopin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NYX gene promoter:
         LHX3b/Lhx3b   AML1a   Tal-1beta   HNF-3beta   Arnt   E47   C/EBPalpha   SRY   LHX3a/Lhx3a   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNYX promoter sequence
   Search Chromatin IP Primers for NYX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NYX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4   Ensembl cytogenetic band:  Xp11.4   HGNC cytogenetic band: Xp11.4

NYX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NYX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP041306:  view genomic region     (about GC identifiers)

Start:
41,306,687 bp from pter      End:
41,334,963 bp from pter
Size:
28,277 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NYX_HUMAN, Q9GZU5 (See protein sequence)
Recommended Name: Nyctalopin precursor  
Size: 481 amino acids; 52000 Da
Secondary accessions: D3DWC0 Q2M1S4 Q5H983 Q9H4J0

Explore the universe of human proteins at neXtProt for NYX: NX_Q9GZU5

Explore proteomics data for NYX at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn97, Asn183, Asn300, Asn393, Asn432, Asn439
  • Modification sites at PhosphoSitePlus

  • See NYX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_072089.1  
    ENSEMBL proteins: 
     ENSP00000340328   ENSP00000367465  

    NYX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NYX
    OriGene Protein Over-expression Lysate for NYX
    OriGene MassSpec for NYX
    OriGene Custom Protein Services for NYX
    GenScript Custom Purified and Recombinant Proteins Services for NYX
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NYX

     
    Search eBioscience for Proteins for NYX 

    NYX Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NYX
    Abcam antibodies for NYX
    Cloud-Clone Corp. Antibodies for NYX
    ThermoFisher Antibodies for NYX
    LSBio Antibodies in human, mouse, rat for NYX

    NYX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NYX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NYX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NYX
    Cloud-Clone Corp. CLIAs for NYX
    Search eBioscience for ELISAs for NYX 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q9GZU5

    ProtoNet protein and cluster: Q9GZU5

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: NYX_HUMAN, Q9GZU5
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily
    Similarity: Contains 11 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with NYX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NYX           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NYX:
     Decreased G3BP1 protein expres  Increased circadian period len 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nyx):
     vision/eye 

    Find genes that share phenotypes with NYX           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NYX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NYX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NYX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NYX

    miRNA
    Products:
        
    miRTarBase miRNAs that target NYX:
    hsa-mir-26b-5p (MIRT028759)

    Block miRNA regulation of human, mouse, rat NYX using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate NYX:
    hsa-miR-2116* hsa-miR-516b hsa-miR-3116 hsa-miR-3612 hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidNYX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NYX
    Predesigned siRNA for gene silencing in human, mouse, rat NYX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NYX

    Clone
    Products:
         
    OriGene clones in human, mouse for NYX (see all 5)
    OriGene ORF clones in mouse, rat for NYX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NYX (NM_022567)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NYX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NYX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NYX
    Browse ESI BIO Cell Lines and PureStem Progenitors for NYX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NYX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NYX_HUMAN, Q9GZU5: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005622intracellular IDA11062471

    Find genes that share ontologies with NYX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NYX
    Interactions:

        Search GeneGlobe Interaction Network for NYX

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007601visual perception IEA--
    GO:0008150biological_process ND--
    GO:0050896response to stimulus IEA--

    Find genes that share ontologies with NYX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NYX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NYX gene: 
    NM_022567.2  

    Unigene Cluster for NYX:

    Nyctalopin
    Hs.302019  [show with all ESTs]
    Unigene Representative Sequence: AJ278865
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342595(uc004dfh.2) ENST00000378220(uc011mku.1) ENST00000486842

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NYX using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate NYX:
    hsa-miR-2116* hsa-miR-516b hsa-miR-3116 hsa-miR-3612 hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidNYX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NYX
    Predesigned siRNA for gene silencing in human, mouse, rat NYX
    Clone
    Products:
         
    OriGene clones in human, mouse for NYX (see all 5)
    OriGene ORF clones in mouse, rat for NYX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NYX (NM_022567)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NYX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NYX
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NYX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NYX
      QuantiTect SYBR Green Assays in human, mouse, rat NYX
      QuantiFast Probe-based Assays in human, mouse, rat NYX

    Additional mRNA sequence: 

    AF254868.1 AJ278865.1 BC112242.1 

    1 DOTS entry:

    DT.75185711 

    5 AceView cDNA sequences:

    AJ278865 AF254868 NM_022567 AI861796 BX280145 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NYX    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                    -               
    SP2:                                    
    SP3:                    -               


    ECgene alternative splicing isoforms for NYX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NYX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCCTCCT
    NYX Expression
    About this image


    NYX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    NYX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NYX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302019

    UniProtKB/Swiss-Prot: NYX_HUMAN, Q9GZU5
    Tissue specificity: Expressed in kidney and retina. Also at low levels in brain, testis and muscle. Within the
    retina, expressed in the inner segment of photoreceptors, outer and inner nuclear layers and the ganglion cell
    layer

        Custom PCR Arrays for NYX
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NYX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NYX
    QuantiTect SYBR Green Assays in human, mouse, rat NYX
    QuantiFast Probe-based Assays in human, mouse, rat NYX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NYX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NYX gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nyx1 , 5 nyctalopin1, 5 85.51(n)1
    85.81(a)1
      X (8.37 cM)5
    2366901  NM_173415.41  NP_775591.11 
     134661105 
    chicken
    (Gallus gallus)
    Aves NYX1 nyctalopin 63.08(n)
    60.77(a)
      418566  XM_004934610.1  XP_004934667.1 
    lizard
    (Anolis carolinensis)
    Reptilia NYX6
    nyctalopin
    53(a)
    1 ↔ 1
    3(134143264-134145101)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nyx1 nyctalopin 55.91(n)
    56.4(a)
      100495354  XM_002932799.2  XP_002932845.2 
    zebrafish
    (Danio rerio)
    Actinopterygii 570958282   -- 70.56(n)    57095828 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15046
    --
    21(a)
    1 → many
    X(20181336-20186734)
    worm
    (Caenorhabditis elegans)
    Secernentea lron-126
    Protein LRON-12 (lron-12) mRNA, complete cds
    17(a)
    1 → many
    III(12114564-12118470) WBGene00013542


    ENSEMBL Gene Tree for NYX (if available)
    TreeFam Gene Tree for NYX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NYX gene
    LRRC532  RTN4R2  LRRC702  RTN4RL12  RTN4RL22  

    Find genes that share paralogs with NYX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NYX (see all 512)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0138794
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138792 L P mis40--------
    VAR_0138824
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138822 G V mis40--------
    VAR_0138744
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138742 N S mis40--------
    VAR_0138714
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138712 L P mis40--------
    VAR_0138784
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138782 F S mis40--------
    VAR_0138674
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138672 C S mis40--------
    VAR_0138734
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138732 L Q mis40--------
    VAR_0138764
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138762 N K mis40--------
    VAR_0138754
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138752 L P mis40--------
    VAR_0138704
    Night blindness, congenital stationary, 1A (CSNB1A)4--see VAR_0138702 P R mis40--------

    HapMap Linkage Disequilibrium report for NYX (41306687 - 41334963 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NYX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508763CNV Insertion20534489
    esv33720CNV Loss17666407
    esv25432CNV Loss19812545

    Human Gene Mutation Database (HGMD): NYX
    Locus Specific Mutation Databases (LSDB): NYX

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NYX
    DNA2.0 Custom Variant and Variant Library Synthesis for NYX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300278   
    OMIM disorders: 310500  
    UniProtKB/Swiss-Prot: NYX_HUMAN, Q9GZU5
  • Night blindness, congenital stationary, 1A (CSNB1A) [MIM:310500]: A non-progressive retinal disorder
    characterized by impaired night vision. Congenital stationary night blindness type 1A is characterized by
    impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 17 diseases for NYX:    
    About MalaCards
    nyx-related x-linked congenital stationary night blindness    irregular astigmatism    hereditary night blindness    night blindness, congenital stationary , 1a, x-linked
    x-linked congenital stationary night blindness    hyperopia    night blindness    astigmatism
    blindness    congenital stationary night blindness    blue cone monochromacy    aland island eye disease
    myopia    night blindness, congenital stationary , 1d, autosomal recessive    achromatopsia    eye disease
    retinal disease

    7 diseases from the University of Copenhagen DISEASES database for NYX:
    Congenital stationary night blindness     Myopia     Aland Island eye disease     Irregular astigmatism
    Hereditary night blindness     Achromatopsia     Blue cone monochromacy

    Find genes that share disorders with NYX           About GenesLikeMe

    8 Novoseek inferred disease relationships for NYX gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    csnb1 99 26 12610835 (3), 15584351 (2), 11581222 (2), 12714669 (2) (see all 15)
    night blindness, congenital stationary 98.1 19 12397430 (2), 17392683 (2), 14507859 (2), 15331616 (1) (see all 11)
    csnb2 93.9 4 15584351 (1), 15583843 (1), 12610835 (1)
    night blindness 84.8 6 17392683 (3), 11581222 (1), 15905181 (1)
    oguchis disease 82.8 1 15584351 (1)
    myopia 61 6 17392683 (6)
    retinopathy 50 3 15905181 (1), 11408949 (1)
    genetic disorder 38.2 1 15331616 (1)

    GeneTests: NYX
    GeneReviews: NYX
    Genetic Association Database (GAD): NYX
    Human Genome Epidemiology (HuGE) Navigator: NYX (3 documents)

    Export disorders for NYX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NYX gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with NYX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness. (PubMed id 11062471)1, 2, 3, 9 Bech-Hansen N.T.... Weleber R.G. (Nat. Genet. 2000)
    2. The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein. (PubMed id 11062472)1, 2, 3, 9 Pusch C.M.... Meindl A. (Nat. Genet. 2000)
    3. Mutations in NYX of individuals with high myopia, but without night blindness. (PubMed id 17392683)1, 4, 9 Zhang Q....Hejtmancik J.F. (Mol. Vis. 2007)
    4. Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip. (PubMed id 20801516)1, 4 Booij J.C....Florijn R.J. (Ophthalmology 2011)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. NYX (nyctalopin on chromosome X), the gene mutated in congenital stationary night blindness, encodes a cell surface protein. (PubMed id 14507859)1, 9 Zeitz C....Berger W. (amp 2003)
    8. A common NYX mutation in Flemish patients with X linked CSNB. (PubMed id 18617546)1, 9 Leroy B.P....Zeitz C. (Br J Ophthalmol 2009)
    9. Localization of nyctalopin in the mammalian retina. (PubMed id 16553780)1, 9 Morgans C.W....Akileswaran L. (Eur. J. Neurosci. 2006)
    10. Novel mutations in CACNA1F and NYX in Dutch families with X-linked congenital stationary night blindness. (PubMed id 15761389)1, 9 Zeitz C....Berger W. (Mol. Vis. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 60506 HGNC: 8082 AceView: NYX Ensembl:ENSG00000188937 euGenes: HUgn60506
    ECgene: NYX H-InvDB: NYX

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NYX Pharmacogenomics, SNPs, Pathways
    Mutations of the NYX genehttp://www.retina-international.org/files/sci-news/nyxmut.htm

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NYX gene:
    Search GeneIP for patents involving NYX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NYX  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NYX  
     OriGene MassSpec something-or-other for NYX   OriGene clones in human, mouse for NYX  
     OriGene qSTAR qPCR primer pairs in human, mouse for NYX   OriGene Purified Protein for NYX  
     OriGene ORF clones in mouse, rat for NYX   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NYX   OriGene Custom Protein Services for NYX  

     
     
     Block miRNA regulation of human, mouse, rat NYX using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NYX
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NYX Predesigned siRNA for gene silencing in human, mouse, rat NYX
     QuantiFast Probe-based Assays in human, mouse, rat NYX QuantiTect SYBR Green Assays in human, mouse, rat NYX
     Custom PCR Arrays for NYX Search Chromatin IP Primers for NYX
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NYX  Search GeneGlobe Interaction Network for NYX
     Regulatory tfbs in NYX promoter
     GenScript Custom Purified and Recombinant Proteins Services for NYX GenScript cDNA clones with any tag delivered in your preferred vector for NYX
     GenScript Custom Assay Services for NYX GenScript Custom overexpressing Cell Line Services for NYX
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NYX
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for NYX
     See all of Abcam's Antibodies, Kits and Proteins for NYX
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NYX
     Antibodies for NYX
     ELISAs for NYX
     CLIAs for NYX



     Browse ESI BIO Cell Lines and PureStem Progenitors for NYX
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NYX
     SwitchGear 3'UTR luciferase reporter plasmids for NYX
     SwitchGear Promoter luciferase reporter plasmids for NYX
     ThermoFisher Antibodies for NYX
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NYX
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NYX
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NYX
     LSBio Antibodies in human, mouse, rat for NYX
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NYX
      Search eBioscience for proteins for NYX
      Search eBioscience for elisas for NYX
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NYX gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4