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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NYNRIN Gene

protein-coding GIFtS: 45
GCID: GC14P024868

NYN domain and retroviral integrase containing

(Previous name: KIAA1305 )
(Previous symbol: KIAA1305)

Explore 1 disease affiliated with
NYNRIN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NYN Domain And Retroviral Integrase Containing¹ ²		NYN Domain And Retroviral Integrase Catalytic Domain-Containing Protein² ³
CGIN1¹ ² ³		FLJ11811¹
KIAA1305¹ ² ³		Cousin Of GIN1²
Protein Cousin Of GIN1² ³		Protein NYNRIN²

External Ids:	HGNC: 20165¹	Entrez Gene: 57523²	Ensembl: ENSG00000205978⁷	UniProtKB: Q9P2P1³

Export aliases for NYNRIN gene to outside databases

Previous GC identifers: GC14P023938 GC14P004982

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for NYNRIN
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NYNRIN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NYNRIN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11.2

NYNRIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NYNRIN gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P024868: view genomic region (about GC identifiers)

Start:	24,867,992 bp from pter	End:	24,888,494 bp from pter
Size:	20,503 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NYNRI_HUMAN, Q9P2P1 (See protein sequence)

Recommended Name: Protein NYNRIN

Size: 1898 amino acids; 208366 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Miscellaneous: The gene encoding this protein may have arisen from the fusion of a cellular gene with retroviral

sequences prior to the marsupial-eutherian split. Sequence and structural analyses suggest that the integrase

catalytic domain is inactive

Sequence caution: Sequence=AAH65283.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence;

Secondary accessions: Q6P153 Q86TR3 Q9HAC4

Alternative splicing: 2 isoforms: Q9P2P1-1 Q9P2P1-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NYNRIN: NX_Q9P2P1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P2P1

NYNRIN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079357.2

ENSEMBL proteins:

ENSP00000371994

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0016021	integral to membrane	IEA	--

NYNRIN for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NYNRIN for domains About GeneDecksing

3 InterPro domains/families:

IPR001584 Integrase_cat-core

IPR021869 RNase_Zc3h12

IPR012337 RNaseH-like_dom

Graphical View of Domain Structure for InterPro Entry Q9P2P1

ProtoNet protein and cluster: Q9P2P1

1 Blocks protein family: IPB001584 Integrase

UniProtKB/Swiss-Prot: NYNRI_HUMAN, Q9P2P1

Similarity: Contains 1 integrase catalytic domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003676	nucleic acid binding	IEA	--

NYNRIN for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NYNRIN:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NYNRIN

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for NYNRIN (Q9P2P1^{2, 3} ENSP00000371994⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGTPBP1	Q9UPW5²^,³, ENSP00000338512⁴	MINT-2875141 I2D: score=3 STRING: ENSP00000338512
CCDC115	ENSP00000259229⁴	STRING: ENSP00000259229

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--
GO:0015074	DNA integration	IEA	--

NYNRIN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for NYNRIN gene:

NM_025081.2

Unigene Cluster for NYNRIN:

NYN domain and retroviral integrase containing

Hs.288348 [show with all ESTs]

Unigene Representative Sequence: NM_025081

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382554(uc001wpf.4) ENST00000554505

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		hsa-miR-3164 hsa-let-7d hsa-miR-15a hsa-miR-503 hsa-miR-486-3p hsa-let-7g hsa-miR-124 hsa-miR-424

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Additional cDNA sequence:

AB037726.2 AK021873.1 BC008219.1 BC065283.1 BX248773.1

4 DOTS entries:

DT.212215 DT.100695763 DT.100775313 DT.97825991

24/78 AceView cDNA sequences (see all 78):

C00733 BU741587 AA904759 BU553982 BX248773 AB037726 BF820756 CR596800

BF928021 BF820599 AI193621 BU677990 BI826667 BQ016345 BX097429 AU119662

AA639626 T51307 AA478643 BM971859 BX480092 BE867659 CB133708 BC008219

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NYNRIN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAGGGTTC

About this image

NYNRIN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NYNRIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NYNRIN

SOURCE GeneReport for Unigene cluster: Hs.288348

SABiosciences Custom PCR Arrays for NYNRIN

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NYNRIN gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	27(a)	1 → many	GL343220.1(751424-765209)
zebrafish (Danio rerio)	Actinopterygii	BX571691.1⁶	--	25(a)	1 → many	7(1506079-1534415)
fruit fly (Drosophila melanogaster)	Insecta	CG42360⁶	--	16(a)	1 → many	2R(20494812-20498049)

ENSEMBL Gene Tree for NYNRIN (if available)
TreeFam Gene Tree for NYNRIN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NYNRIN gene

N4BP1² ZC3H12C² ZC3H12B² ZC3H12D² KHNYN² ZC3H12A²

NYNRIN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75860222^1,2		--	24866041(+)	`TTCTTC/ATTCCT`	1	--	us2k¹		1		NA	120
rs146820279^1,2		--	24866134(+)	`AATACA/GTGTTA`	1	--	us2k¹		0	--	--	--	--
rs181033031^1,2		--	24866155(+)	`ATAAGC/TGAATG`	1	--	us2k¹		0	--	--	--	--
rs185920418^1,2		--	24866169(+)	`TTGGTC/TCTATG`	1	--	us2k¹		0	--	--	--	--
rs191974304^1,2		--	24866201(+)	`CCATGC/GAGTTC`	1	--	us2k¹		0	--	--	--	--
rs113256174^1,2		--	24866414(+)	`GAAGAG/AACAAG`	1	--	us2k¹		1		CSA	2
rs183132147^1,2		--	24866493(+)	`CATGTA/TGTCTG`	1	--	us2k¹		0	--	--	--	--
rs75520893^1,2		--	24866544(+)	`ATGAGC/TTAAAG`	1	--	us2k¹		3		CSA WA NA	240
rs57437663^1,2	C,F,	--	24866685(+)	`CATGAA/GGATGA`	1	--	us2k¹		5		NA CSA WA EA	362
rs145625689^1,2		--	24866710(+)	`GTTCAC/TGGTCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NYNRIN (24867992 - 24888494 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NYNRIN: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NYNRIN for disorders About GeneDecksing

1 disease for NYNRIN: About MalaCards

ataxia

Export disorders for NYNRIN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NYNRIN gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with NYNRIN)

Utopia: connect your pdf to the dynamic
world of online information

CGIN1: a retroviral contribution to mammalian genomes . (PubMed id 19561090)^{1, 3} Marco A. and MarA-n I. (2009)
The NYN domains: novel predicted RNAses with a PIN do main-like fold. (PubMed id 17114934)^{1, 3} Anantharaman V. and Aravind L. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (2000)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)¹ Teslovich T.M....Kathiresan S. (2010)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)² Heilig R.... Weissenbach J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57523	HGNC: 20165	AceView: KIAA1305	Ensembl:ENSG00000205978	euGenes: HUgn57523
ECgene: NYNRIN	H-InvDB: NYNRIN

(According to HUGE)
About This Section

HUGE: KIAA1305

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NYNRIN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NYNRIN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NYNRIN gene:
Search GeneIP for patents involving NYNRIN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NYNRIN

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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NYNRIN Gene

NYN domain and retroviral integrase containing

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NYNRIN Gene

NYN domain and retroviral integrase containing

Aliasesfor NYNRIN gene

Summariesfor NYNRIN gene

Genomic Viewsfor NYNRIN gene

Proteinsfor NYNRIN gene

Protein Domains /Familiesfor NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

Expression
for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene

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for NYNRIN gene