Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NYNRIN Gene

Aliases for NYNRIN Gene

  • NYN Domain And Retroviral Integrase Containing 2 3 5
  • KIAA1305 2 3 4
  • NYN Domain And Retroviral Integrase Catalytic Domain-Containing Protein 3 4
  • Protein Cousin Of GIN1 3 4
  • Cousin Of GIN1 2 3
  • CGIN1 3 4
  • Protein NYNRIN 3

External Ids for NYNRIN Gene

Previous HGNC Symbols for NYNRIN Gene

  • KIAA1305

Previous GeneCards Identifiers for NYNRIN Gene

  • GC14P023938
  • GC14P024868
  • GC14P004982

Summaries for NYNRIN Gene

GeneCards Summary for NYNRIN Gene

NYNRIN (NYN Domain And Retroviral Integrase Containing) is a Protein Coding gene. Diseases associated with NYNRIN include Endocervical Carcinoma. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is KHNYN.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NYNRIN Gene

Genomics for NYNRIN Gene

Regulatory Elements for NYNRIN Gene

Enhancers for NYNRIN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G023445 1.1 ENCODE dbSUPER 48.2 -951.7 -951716 3.1 ZFP64 ZNF121 ZNF202 ZNF680 ZBTB11 ZNF426 REST ZNF623 ZNF781 ZNF518A NYNRIN KHNYN NFATC4 RNA5SP383 MMP14 MIR208B HOMEZ MYH6 THTPA SLC22A17
GH14G024397 1.2 ENCODE dbSUPER 28.4 +2.0 2030 6.7 FOXA2 KLF17 PLRG1 ZNF48 RARA GLIS2 FOS PCBP1 SP3 ZHX2 NYNRIN KHNYN ADCY4 RIPK3 CBLN3 NFATC4 LTB4R
GH14G023566 1.4 Ensembl ENCODE 22 -830.5 -830463 3.7 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 KHNYN RNA5SP383 MMP14 NYNRIN AP1G2 C14orf119 LOC102724814 NFATC4 HOMEZ ABHD4
GH14G024441 1.4 ENCODE dbSUPER 20.8 +43.8 43780 2.5 HDGF PKNOX1 FOXA2 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 SDR39U1 NYNRIN NFATC4 KHNYN RNA5SP383 MDP1 ENSG00000258744 GC14P024445 PIR37686 CBLN3
GH14G024435 1.1 ENCODE dbSUPER 22.1 +38.3 38326 3.1 ELF3 ARID4B THRB RAD21 YY1 ZNF143 FOS ZNF548 IKZF2 BCLAF1 SDR39U1 NYNRIN NOP9 KHNYN RNA5SP383 ADCY4 CIDEB LTB4R LTB4R2 DHRS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NYNRIN on UCSC Golden Path with GeneCards custom track

Promoters for NYNRIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066875 214 801 KLF1 KLF17 ZNF48 ZNF7 GLIS2 ZBTB48 POLR2A PATZ1 PCBP1 ZNF652

Genomic Location for NYNRIN Gene

Chromosome:
14
Start:
24,398,786 bp from pter
End:
24,419,288 bp from pter
Size:
20,503 bases
Orientation:
Plus strand

Genomic View for NYNRIN Gene

Genes around NYNRIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NYNRIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NYNRIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYNRIN Gene

Proteins for NYNRIN Gene

  • Protein details for NYNRIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2P1-NYNRI_HUMAN
    Recommended name:
    Protein NYNRIN
    Protein Accession:
    Q9P2P1
    Secondary Accessions:
    • Q6P153
    • Q86TR3
    • Q9HAC4

    Protein attributes for NYNRIN Gene

    Size:
    1898 amino acids
    Molecular mass:
    208366 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene encoding this protein may have arisen from the fusion of a cellular gene with retroviral sequences prior to the marsupial-eutherian split. Sequence and structural analyses suggest that the integrase catalytic domain is inactive.
    SequenceCaution:
    • Sequence=AAH65283.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYNRIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NYNRIN Gene

Post-translational modifications for NYNRIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYNRIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NYNRIN Gene

Domains & Families for NYNRIN Gene

Protein Domains for NYNRIN Gene

Suggested Antigen Peptide Sequences for NYNRIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NYNRIN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NYNRIN Gene

Function for NYNRIN Gene

Gene Ontology (GO) - Molecular Function for NYNRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with NYNRIN: view
genes like me logo Genes that share phenotypes with NYNRIN: view

Animal Model Products

CRISPR Products

miRNA for NYNRIN Gene

miRTarBase miRNAs that target NYNRIN

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NYNRIN Gene

Localization for NYNRIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NYNRIN Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NYNRIN gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NYNRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NYNRIN: view

Pathways & Interactions for NYNRIN Gene

SuperPathways for NYNRIN Gene

No Data Available

Interacting Proteins for NYNRIN Gene

Gene Ontology (GO) - Biological Process for NYNRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0015074 DNA integration IEA --
genes like me logo Genes that share ontologies with NYNRIN: view

No data available for Pathways by source and SIGNOR curated interactions for NYNRIN Gene

Drugs & Compounds for NYNRIN Gene

(7) Drugs for NYNRIN Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atazanavir Approved, Investigational Pharma HIV protease inhibitor,highly potent 0
BMS-707035 Pharma HIV-I integrase inhibitor,potent and specific 0
Elvitegravir (GS-9137) Pharma HIV-1 integrase inhibitor,potent 0
Fluorouracil (Adrucil) Pharma Antitumor agent;inhibitor of thymidylate synthase 0
GSK744 (S/GSK1265744) Pharma HIV integrase inhibitor, oral active and long-acting 0

(7) ApexBio Compounds for NYNRIN Gene

Compound Action Cas Number
Atazanavir HIV protease inhibitor,highly potent 198904-31-3
BMS-707035 HIV-I integrase inhibitor,potent and specific 729607-74-3
Elvitegravir (GS-9137) HIV-1 integrase inhibitor,potent 697761-98-1
Fluorouracil (Adrucil) Antitumor agent;inhibitor of thymidylate synthase 51-21-8
GSK744 (S/GSK1265744) HIV integrase inhibitor, oral active and long-acting 1051375-10-0
MK-2048 Integrase inhibitor for HIV-1,second generation 869901-69-9
Raltegravir (MK-0518) HIV-1 integrase inhibitor 518048-05-0
genes like me logo Genes that share compounds with NYNRIN: view

Drug Products

Transcripts for NYNRIN Gene

mRNA/cDNA for NYNRIN Gene

Unigene Clusters for NYNRIN Gene

NYN domain and retroviral integrase containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NYNRIN Gene

No ASD Table

Relevant External Links for NYNRIN Gene

GeneLoc Exon Structure for
NYNRIN
ECgene alternative splicing isoforms for
NYNRIN

Expression for NYNRIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NYNRIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NYNRIN Gene

This gene is overexpressed in Brain - Cerebellum (x4.2) and Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for NYNRIN Gene

This gene is overexpressed in Lung (38.8), Pancreatic juice (8.0), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NYNRIN Gene



NURSA nuclear receptor signaling pathways regulating expression of NYNRIN Gene:

NYNRIN

SOURCE GeneReport for Unigene cluster for NYNRIN Gene:

Hs.288348

Evidence on tissue expression from TISSUES for NYNRIN Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with NYNRIN: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NYNRIN Gene

Orthologs for NYNRIN Gene

This gene was present in the common ancestor of animals.

Orthologs for NYNRIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NYNRIN 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia NYNRIN 34 35
  • 86.25 (n)
dog
(Canis familiaris)
Mammalia NYNRIN 34 35
  • 86.06 (n)
mouse
(Mus musculus)
Mammalia Nynrin 34 16 35
  • 81.63 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912447 34
  • 80.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii KHNYN 35
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10889 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30F12.1 35
  • 17 (a)
OneToMany
Species where no ortholog for NYNRIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NYNRIN Gene

ENSEMBL:
Gene Tree for NYNRIN (if available)
TreeFam:
Gene Tree for NYNRIN (if available)

Paralogs for NYNRIN Gene

Paralogs for NYNRIN Gene

genes like me logo Genes that share paralogs with NYNRIN: view

Variants for NYNRIN Gene

Sequence variations from dbSNP and Humsavar for NYNRIN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000110992 -- 24,406,350(+) TTTTC(A/G)TGTTG intron-variant
rs1000123539 -- 24,402,600(+) GAGTT(C/G)GCTCC intron-variant
rs1000712896 -- 24,407,835(+) AACGG(A/G)CTGAC intron-variant
rs1000775267 -- 24,413,711(+) ATTCA(C/T)GTAGC intron-variant
rs1000777789 -- 24,409,339(+) CCAGT(A/G)CTGCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NYNRIN Gene

Variant ID Type Subtype PubMed ID
nsv1112645 CNV deletion 24896259

Variation tolerance for NYNRIN Gene

Residual Variation Intolerance Score: 3.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NYNRIN Gene

Human Gene Mutation Database (HGMD)
NYNRIN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NYNRIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NYNRIN Gene

Disorders for NYNRIN Gene

MalaCards: The human disease database

(1) MalaCards diseases for NYNRIN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endocervical carcinoma
  • carcinoma of endocervix
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NYNRIN

Genetic Association Database (GAD)
NYNRIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NYNRIN
genes like me logo Genes that share disorders with NYNRIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NYNRIN Gene

Publications for NYNRIN Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 46 64
  2. CGIN1: a retroviral contribution to mammalian genomes. (PMID: 19561090) Marco A. … MarA-n I. (Mol. Biol. Evol. 2009) 2 3 64
  3. The NYN domains: novel predicted RNAses with a PIN domain-like fold. (PMID: 17114934) Anantharaman V. … Aravind L. (RNA Biol 2006) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for NYNRIN Gene

Sources for NYNRIN Gene

Content
Loading form....