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Aliases for NYNRIN Gene

Aliases for NYNRIN Gene

  • NYN Domain And Retroviral Integrase Containing 2 3
  • KIAA1305 2 3 4
  • NYN Domain And Retroviral Integrase Catalytic Domain-Containing Protein 3 4
  • Protein Cousin Of GIN1 3 4
  • Cousin Of GIN1 2 3
  • CGIN1 3 4
  • Protein NYNRIN 3

External Ids for NYNRIN Gene

Previous HGNC Symbols for NYNRIN Gene

  • KIAA1305

Previous GeneCards Identifiers for NYNRIN Gene

  • GC14P023938
  • GC14P024868
  • GC14P004982

Summaries for NYNRIN Gene

GeneCards Summary for NYNRIN Gene

NYNRIN (NYN Domain And Retroviral Integrase Containing) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is N4BP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NYNRIN Gene

Genomics for NYNRIN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NYNRIN Gene

24,398,786 bp from pter
24,419,288 bp from pter
20,503 bases
Plus strand

Genomic View for NYNRIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NYNRIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYNRIN Gene

No data available for Regulatory Elements for NYNRIN Gene

Proteins for NYNRIN Gene

  • Protein details for NYNRIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NYNRIN
    Protein Accession:
    Secondary Accessions:
    • Q6P153
    • Q86TR3
    • Q9HAC4

    Protein attributes for NYNRIN Gene

    1898 amino acids
    Molecular mass:
    208366 Da
    Quaternary structure:
    No Data Available
    • The gene encoding this protein may have arisen from the fusion of a cellular gene with retroviral sequences prior to the marsupial-eutherian split. Sequence and structural analyses suggest that the integrase catalytic domain is inactive
    • Sequence=AAH65283.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYNRIN Gene


neXtProt entry for NYNRIN Gene

Proteomics data for NYNRIN Gene at MOPED

Post-translational modifications for NYNRIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYNRIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NYNRIN Gene

Domains for NYNRIN Gene

Protein Domains for NYNRIN Gene

Suggested Antigen Peptide Sequences for NYNRIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 integrase catalytic domain.
  • Contains 1 integrase catalytic domain.
genes like me logo Genes that share domains with NYNRIN: view

No data available for Gene Families for NYNRIN Gene

Function for NYNRIN Gene

Gene Ontology (GO) - Molecular Function for NYNRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding --
genes like me logo Genes that share ontologies with NYNRIN: view

Phenotypes for NYNRIN Gene

GenomeRNAi human phenotypes for NYNRIN:
genes like me logo Genes that share phenotypes with NYNRIN: view

Animal Model Products

CRISPR Products

miRNA for NYNRIN Gene

miRTarBase miRNAs that target NYNRIN

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NYNRIN

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NYNRIN Gene

Localization for NYNRIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NYNRIN Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NYNRIN Gene COMPARTMENTS Subcellular localization image for NYNRIN gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NYNRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NYNRIN: view

Pathways for NYNRIN Gene

SuperPathways for NYNRIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NYNRIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0015074 DNA integration IEA --
genes like me logo Genes that share ontologies with NYNRIN: view

No data available for Pathways by source for NYNRIN Gene

Drugs for NYNRIN Gene

(7) ApexBio Compounds for NYNRIN Gene

Compound Action Cas Number
Atazanavir HIV protease inhibitor,highly potent [198904-31-3]
BMS-707035 HIV-I integrase inhibitor,potent and specific [729607-74-3]
Elvitegravir (GS-9137) HIV-1 integrase inhibitor,potent [697761-98-1]
Fluorouracil (Adrucil) Antitumor agent;inhibitor of thymidylate synthase [51-21-8]
GSK744 (S/GSK1265744) HIV integrase inhibitor, oral active and long-acting [1051375-10-0]
MK-2048 Integrase inhibitor for HIV-1,second generation [869901-69-9]
Raltegravir (MK-0518) HIV-1 integrase inhibitor [518048-05-0]
genes like me logo Genes that share compounds with NYNRIN: view

Transcripts for NYNRIN Gene


Unigene Clusters for NYNRIN Gene

NYN domain and retroviral integrase containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NYNRIN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NYNRIN Gene

No ASD Table

Relevant External Links for NYNRIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NYNRIN Gene

mRNA expression in normal human tissues for NYNRIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NYNRIN Gene

This gene is overexpressed in Brain - Cerebellum (4.2) and Ovary (4.1).

Protein differential expression in normal tissues for NYNRIN Gene

This gene is overexpressed in Lung (38.8), Pancreatic juice (8.0), and Heart (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NYNRIN Gene

SOURCE GeneReport for Unigene cluster for NYNRIN Gene Hs.288348

genes like me logo Genes that share expressions with NYNRIN: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for NYNRIN Gene

Orthologs for NYNRIN Gene

This gene was present in the common ancestor of animals.

Orthologs for NYNRIN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NYNRIN 35
  • 86.25 (n)
  • 83.87 (a)
  • 84 (a)
(Canis familiaris)
Mammalia NYNRIN 35
  • 86.06 (n)
  • 85.65 (a)
  • 86 (a)
(Mus musculus)
Mammalia Nynrin 35
  • 81.63 (n)
  • 78.15 (a)
Nynrin 16
Nynrin 36
  • 78 (a)
(Pan troglodytes)
Mammalia NYNRIN 35
  • 99.37 (n)
  • 99.26 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100912447 35
  • 80.44 (n)
  • 76.26 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
(Danio rerio)
Actinopterygii KHNYN 36
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10889 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea C30F12.1 36
  • 17 (a)
Species with no ortholog for NYNRIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NYNRIN Gene

Gene Tree for NYNRIN (if available)
Gene Tree for NYNRIN (if available)

Paralogs for NYNRIN Gene

Paralogs for NYNRIN Gene

genes like me logo Genes that share paralogs with NYNRIN: view

Variants for NYNRIN Gene

Sequence variations from dbSNP and Humsavar for NYNRIN Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13841 -- 24,419,042(-) CTGGA(C/T)AGGGT utr-variant-3-prime
rs14076 -- 24,419,129(-) GAAAG(A/G)ATGGC utr-variant-3-prime
rs1535338 -- 24,410,612(-) AGCAG(A/G)GTCAG intron-variant
rs1951126 -- 24,399,956(-) CACTC(A/T)AGAAG intron-variant
rs2057322 -- 24,402,723(-) gggtg(A/G)ggggt intron-variant

Relevant External Links for NYNRIN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NYNRIN Gene

Disorders for NYNRIN Gene

Relevant External Links for NYNRIN

Genetic Association Database (GAD)

No disorders were found for NYNRIN Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NYNRIN Gene

Publications for NYNRIN Gene

  1. The NYN domains: novel predicted RNAses with a PIN domain-like fold. (PMID: 17114934) Anantharaman V. … Aravind L. (RNA Biol 2006) 2 3
  2. CGIN1: a retroviral contribution to mammalian genomes. (PMID: 19561090) Marco A. … MarA-n I. (Mol. Biol. Evol. 2009) 2 3
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NYNRIN Gene

Sources for NYNRIN Gene

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