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Aliases for NYAP2 Gene

Aliases for NYAP2 Gene

  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2 2 3 5
  • KIAA1486 2 3 4
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adapter 2 3

External Ids for NYAP2 Gene

Previous HGNC Symbols for NYAP2 Gene

  • KIAA1486

Previous GeneCards Identifiers for NYAP2 Gene

  • GC02P226265

Summaries for NYAP2 Gene

GeneCards Summary for NYAP2 Gene

NYAP2 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2) is a Protein Coding gene. An important paralog of this gene is NYAP1.

UniProtKB/Swiss-Prot for NYAP2 Gene

  • Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NYAP2 Gene

Genomics for NYAP2 Gene

Regulatory Elements for NYAP2 Gene

Enhancers for NYAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F224951 0.4 ENCODE 8.4 -447.7 -447686 1.3 PKNOX1 TBL1XR1 ZBED1 IKZF1 EED JUNB ETV6 CREM GABPA NYAP2 DOCK10 PIR37983 MIR4439
GH02F224929 0.8 Ensembl ENCODE 8.2 -468.0 -468047 3.9 CTCF MXI1 MTA2 IKZF1 SMC3 ZBTB33 RAD21 SPI1 NYAP2 DOCK10 PIR37983 GC02P224823
GH02F224920 1.5 FANTOM5 Ensembl ENCODE 8.2 -475.0 -475033 9.4 HDGF PKNOX1 JUN BMI1 CBX5 EED ETV6 FOS CREM RFX1 DOCK10 NYAP2 CUL3 PIR37983 GC02P224823
GH02F224908 1.7 FANTOM5 Ensembl ENCODE 8 -489.4 -489379 2.9 PKNOX1 BMI1 FEZF1 CEBPG RFX5 GATA3 SCRT2 PRDM10 NFE2 RFX1 DOCK10 NYAP2 CUL3 PIR37983 GC02P224823
GH02F224943 1.1 FANTOM5 ENCODE 8 -453.2 -453169 6.9 HDGF CTCF TBP PKNOX1 JUN SIN3A EBF1 RAD21 ZBTB40 POLR2A DOCK10 NYAP2 CUL3 PIR37983 MIR4439
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NYAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NYAP2 Gene

Chromosome:
2
Start:
225,399,710 bp from pter
End:
225,703,653 bp from pter
Size:
303,944 bases
Orientation:
Plus strand

Genomic View for NYAP2 Gene

Genes around NYAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NYAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NYAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYAP2 Gene

Proteins for NYAP2 Gene

  • Protein details for NYAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P242-NYAP2_HUMAN
    Recommended name:
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
    Protein Accession:
    Q9P242
    Secondary Accessions:
    • A2RRN4
    • Q96NL2

    Protein attributes for NYAP2 Gene

    Size:
    653 amino acids
    Molecular mass:
    70548 Da
    Quaternary structure:
    • Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
    SequenceCaution:
    • Sequence=BAA96010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NYAP2 Gene

Post-translational modifications for NYAP2 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYAP2 Gene

No data available for DME Specific Peptides for NYAP2 Gene

Domains & Families for NYAP2 Gene

Protein Domains for NYAP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P242

UniProtKB/Swiss-Prot:

NYAP2_HUMAN :
  • Belongs to the NYAP family.
Family:
  • Belongs to the NYAP family.
genes like me logo Genes that share domains with NYAP2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NYAP2 Gene

Function for NYAP2 Gene

Molecular function for NYAP2 Gene

UniProtKB/Swiss-Prot Function:
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

Gene Ontology (GO) - Molecular Function for NYAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NYAP2: view

Phenotypes for NYAP2 Gene

GenomeRNAi human phenotypes for NYAP2:
genes like me logo Genes that share phenotypes with NYAP2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NYAP2 Gene

Localization for NYAP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NYAP2 Gene COMPARTMENTS Subcellular localization image for NYAP2 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for NYAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with NYAP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NYAP2 Gene

Pathways & Interactions for NYAP2 Gene

SuperPathways for NYAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NYAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014065 phosphatidylinositol 3-kinase signaling ISS --
GO:0048812 neuron projection morphogenesis ISS --
genes like me logo Genes that share ontologies with NYAP2: view

No data available for Pathways by source and SIGNOR curated interactions for NYAP2 Gene

Transcripts for NYAP2 Gene

mRNA/cDNA for NYAP2 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NYAP2 Gene

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NYAP2 Gene

No ASD Table

Relevant External Links for NYAP2 Gene

GeneLoc Exon Structure for
NYAP2
ECgene alternative splicing isoforms for
NYAP2

Expression for NYAP2 Gene

mRNA expression in normal human tissues for NYAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NYAP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for NYAP2 Gene

This gene is overexpressed in Fetal Brain (38.9), Frontal cortex (16.6), and Heart (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NYAP2 Gene



Protein tissue co-expression partners for NYAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NYAP2 Gene:

NYAP2

SOURCE GeneReport for Unigene cluster for NYAP2 Gene:

Hs.224409
genes like me logo Genes that share expression patterns with NYAP2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NYAP2 Gene

Orthologs for NYAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NYAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NYAP2 34 35
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia NYAP2 34 35
  • 86.65 (n)
dog
(Canis familiaris)
Mammalia NYAP2 34 35
  • 85.25 (n)
rat
(Rattus norvegicus)
Mammalia Nyap2 34
  • 84.84 (n)
mouse
(Mus musculus)
Mammalia Nyap2 34 16 35
  • 83.99 (n)
oppossum
(Monodelphis domestica)
Mammalia NYAP2 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NYAP2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves NYAP2 34 35
  • 78.86 (n)
lizard
(Anolis carolinensis)
Reptilia NYAP2 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nyap2 34
  • 70.68 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100000797 34
  • 59.99 (n)
NYAP2 (1 of 2) 35
  • 49 (a)
OneToMany
NYAP2 (2 of 2) 35
  • 28 (a)
OneToMany
Species where no ortholog for NYAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NYAP2 Gene

ENSEMBL:
Gene Tree for NYAP2 (if available)
TreeFam:
Gene Tree for NYAP2 (if available)

Paralogs for NYAP2 Gene

Paralogs for NYAP2 Gene

(1) SIMAP similar genes for NYAP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NYAP2: view

Variants for NYAP2 Gene

Sequence variations from dbSNP and Humsavar for NYAP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10153830 -- 225,621,895(+) ggctg(A/G)ataat intron-variant
rs10166417 -- 225,616,761(+) ACACA(C/T)CTTAC intron-variant
rs10167137 -- 225,405,765(+) GTTTC(C/T)TTATT intron-variant
rs10167138 -- 225,407,701(+) GAAAG(A/T)AAAAC intron-variant
rs10168306 -- 225,585,656(+) CTTTA(C/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NYAP2 Gene

Variant ID Type Subtype PubMed ID
esv1558776 CNV insertion 17803354
esv25689 CNV loss 19812545
esv2665271 CNV deletion 23128226
esv3427876 CNV insertion 20981092
esv3594490 CNV loss 21293372
esv3594493 CNV loss 21293372
nsv1131555 CNV deletion 24896259
nsv1138894 CNV deletion 24896259
nsv475737 CNV novel sequence insertion 20440878
nsv834556 CNV loss 17160897

Variation tolerance for NYAP2 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NYAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NYAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NYAP2 Gene

Disorders for NYAP2 Gene

Relevant External Links for NYAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NYAP2

No disorders were found for NYAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NYAP2 Gene

Publications for NYAP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K. … Yamamoto T. (EMBO J. 2011) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for NYAP2 Gene

Sources for NYAP2 Gene

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