NYAP2 Gene
protein-coding GIFtS: 39
GCID: GC02P226265
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neuronal tyrosine-phosphorylated phosphoinositide-3-kinase...(Previous name: KIAA1486 )
(Previous symbol: KIAA1486)
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Aliases
for NYAP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 21 2 | | KIAA14861 2 3 | | Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adapter 22 |
Export aliases for NYAP2 gene to outside databases |
Summaries
for NYAP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NYAP2_HUMAN, Q9P242Function: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulatesneuronal morphogenesis (By similarity)
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Genomic Views
for NYAP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NYAP2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NYAP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NYAP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3NYAP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P226265: view genomic region
(about GC identifiers)
Start:
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226,265,364 bp from pter |
End:
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226,518,734 bp from pter |
Size:
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253,371 bases |
Orientation:
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plus strand |
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Proteins
for NYAP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NYAP2_HUMAN, Q9P242 (See
protein sequence)Recommended Name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 Size: 653 amino acids; 70548 Da
Subunit: Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1;this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity)
Sequence caution: Sequence=BAA96010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RRN4 Q96NL2Alternative splicing: 3 isoforms: Q9P242-1 Q9P242-2 Q9P242-3 Explore the universe of human proteins at neXtProt for NYAP2: NX_Q9P242
Post-translational modifications:
Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P242
NYAP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065915.1
ENSEMBL proteins: ENSP00000272907 ENSP00000386437
Human Recombinant Protein Products:
NYAP2 Antibody Products:
Assay Products for NYAP2: |
Protein
Domains /
Families
for NYAP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NYAP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P242ProtoNet protein and cluster: Q9P242 UniProtKB/Swiss-Prot: NYAP2_HUMAN, Q9P242Similarity: Belongs to the NYAP family |
Function
for NYAP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NYAP2_HUMAN, Q9P242Function: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulatesneuronal morphogenesis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NYAP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NYAP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for NYAP2 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NYAP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NYAP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NYAP2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005515 | protein binding |
-- | -- |
NYAP2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NYAP2:
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Pathways & Interactions
for NYAP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NYAP2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0014065 | phosphatidylinositol 3-kinase cascade |
ISS | -- | | GO:0048812 | neuron projection morphogenesis |
ISS | -- |
NYAP2 for ontologies About GeneDecksing
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Drugs & Compounds
for NYAP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NYAP2
Search CenterWatch for drugs/clinical trials and news about NYAP2
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Transcripts
for NYAP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NYAP2 gene: NM_020864.1 Unigene Cluster for NYAP2: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 Hs.224409 [show with all ESTs]Unigene Representative Sequence: NM_0208642 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000272907(uc002voe.2 uc010fxa.1 uc002vof.1) ENST00000409269
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NYAP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NYAP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for NYAP2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NYAP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NYAP2 |
Additional cDNA sequence: AB040919.1 AK055226.1 BC131727.1 3 DOTS entries: DT.120955947 DT.70103142 DT.97799197 8 AceView cDNA sequences: BI828006 AK055226 AB040919 AI825640 AI825189 C15204 BQ338801 AW235426
GeneLoc Exon Structure
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Expression
for NYAP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NYAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTCCTATA
About this image
See NYAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NYAP2
SOURCE GeneReport for Unigene cluster: Hs.224409
SABiosciences Custom PCR Arrays for NYAP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NYAP2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NYAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NYAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NYAP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NYAP2 |
Orthologs
for NYAP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NYAP2 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for NYAP2 (if available)
TreeFam Gene Tree for NYAP2 (if available) |
Paralogs
for NYAP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NYAP2 gene
- NYAP12
1 SIMAP similar gene for NYAP2 using alignment to 2 protein entries: NYAP2_HUMAN (see all proteins):MYO16
NYAP2 for paralogs About GeneDecksing
|
Genomic Variants
for NYAP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for NYAP2 (226265364 - 226515364 bp, first 250kb of NYAP2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NYAP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NYAP2 |
|
Disorders
/ Diseases
for NYAP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NYAP2 for disorders About GeneDecksing
1  disease for NYAP2: About MalaCardsneuronitis
Export disorders for NYAP2 gene to outside databases
|
Publications
for NYAP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NYAP2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with NYAP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
- NYAP: a phosphoprotein family that links PI3K to WAVE 1 signalling in neurons. (PubMed id 21946561)1, 3 Yokoyama K....Yamamoto T. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide pol ymorphisms. (PubMed id 20889853)1 de Miguel-Yanes J.M....Meigs J.B. (2010)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
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External Searches for NYAP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NYAP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NYAP2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NYAP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NYAP2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NYAP2 gene:
Search GeneIP for patents involving NYAP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NYAP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NYAP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NYAP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NYAP2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NYAP2 | | OriGene 3'-UTR Clone for NYAP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NYAP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NYAP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NYAP2 | | OriGene Custom Protein Services for NYAP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NYAP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NYAP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NYAP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NYAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NYAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NYAP2 |
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 |  |  |  | |
| | | | Search Tocris compounds for NYAP2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NYAP2 |
|  |  |  | | | | ThermoFisher Antibodies for NYAP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NYAP2 |
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