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Aliases for NYAP2 Gene

Aliases for NYAP2 Gene

  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2 2 3
  • KIAA1486 2 3 4 6
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adapter 2 3
  • NYPA2 6

External Ids for NYAP2 Gene

Previous HGNC Symbols for NYAP2 Gene

  • KIAA1486

Previous GeneCards Identifiers for NYAP2 Gene

  • GC02P226265

Summaries for NYAP2 Gene

GeneCards Summary for NYAP2 Gene

NYAP2 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2) is a Protein Coding gene. An important paralog of this gene is NYAP1.

UniProtKB/Swiss-Prot for NYAP2 Gene

  • Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NYAP2 Gene

Genomics for NYAP2 Gene

Genomic Location for NYAP2 Gene

225,399,710 bp from pter
225,654,018 bp from pter
254,309 bases
Plus strand

Genomic View for NYAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NYAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYAP2 Gene

No data available for Regulatory Elements for NYAP2 Gene

Proteins for NYAP2 Gene

  • Protein details for NYAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
    Protein Accession:
    Secondary Accessions:
    • A2RRN4
    • Q96NL2

    Protein attributes for NYAP2 Gene

    653 amino acids
    Molecular mass:
    70548 Da
    Quaternary structure:
    • Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
    • Sequence=BAA96010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYAP2 Gene


neXtProt entry for NYAP2 Gene

Proteomics data for NYAP2 Gene at MOPED

Post-translational modifications for NYAP2 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NYAP2 Gene

Domains for NYAP2 Gene

Protein Domains for NYAP2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9P242
  • Belongs to the NYAP family.
genes like me logo Genes that share domains with NYAP2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NYAP2 Gene

Function for NYAP2 Gene

Molecular function for NYAP2 Gene

UniProtKB/Swiss-Prot Function: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

Gene Ontology (GO) - Molecular Function for NYAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NYAP2: view

Phenotypes for NYAP2 Gene

GenomeRNAi human phenotypes for NYAP2:
genes like me logo Genes that share phenotypes with NYAP2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NYAP2 Gene

Localization for NYAP2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NYAP2 Gene

Pathways for NYAP2 Gene

SuperPathways for NYAP2 Gene

No Data Available

Interacting Proteins for NYAP2 Gene

Gene Ontology (GO) - Biological Process for NYAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014065 phosphatidylinositol 3-kinase signaling ISS --
GO:0048812 neuron projection morphogenesis ISS --
genes like me logo Genes that share ontologies with NYAP2: view

No data available for Pathways by source for NYAP2 Gene

Transcripts for NYAP2 Gene

mRNA/cDNA for NYAP2 Gene

(3) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NYAP2 Gene

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NYAP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NYAP2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NYAP2 Gene

No ASD Table

Relevant External Links for NYAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NYAP2 Gene

mRNA expression in normal human tissues for NYAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NYAP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NYAP2 Gene

SOURCE GeneReport for Unigene cluster for NYAP2 Gene Hs.224409

genes like me logo Genes that share expressions with NYAP2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NYAP2 Gene

Orthologs for NYAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NYAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NYAP2 35
  • 99.18 (n)
  • 99.23 (a)
NYAP2 36
  • 99 (a)
(Bos Taurus)
Mammalia NYAP2 35
  • 86.65 (n)
  • 93.63 (a)
NYAP2 36
  • 87 (a)
(Canis familiaris)
Mammalia NYAP2 35
  • 85.25 (n)
  • 90.53 (a)
NYAP2 36
  • 81 (a)
(Mus musculus)
Mammalia Nyap2 35
  • 83.99 (n)
  • 91.42 (a)
Nyap2 16
Nyap2 36
  • 75 (a)
(Monodelphis domestica)
Mammalia NYAP2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia NYAP2 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Nyap2 35
  • 84.84 (n)
  • 91.9 (a)
(Gallus gallus)
Aves NYAP2 35
  • 78.86 (n)
  • 84.46 (a)
NYAP2 36
  • 75 (a)
(Anolis carolinensis)
Reptilia NYAP2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nyap2 35
  • 70.68 (n)
  • 75.27 (a)
(Danio rerio)
Actinopterygii LOC100000797 35
  • 59.99 (n)
  • 61.63 (a)
NYAP2 (1 of 2) 36
  • 49 (a)
NYAP2 (2 of 2) 36
  • 28 (a)
Species with no ortholog for NYAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NYAP2 Gene

Gene Tree for NYAP2 (if available)
Gene Tree for NYAP2 (if available)

Paralogs for NYAP2 Gene

Paralogs for NYAP2 Gene

Selected SIMAP similar genes for NYAP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NYAP2: view

Variants for NYAP2 Gene

Sequence variations from dbSNP and Humsavar for NYAP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs140814 -- 225,607,700(+) TGTTT(-/CTCT/TCTC)ATCAA intron-variant
rs715678 -- 225,600,693(+) TTCAT(C/T)CTTCC intron-variant
rs718659 -- 225,510,105(+) AAGAA(G/T)ATATG intron-variant
rs718660 -- 225,510,312(+) ACTCA(C/T)TAATG intron-variant
rs719762 -- 225,609,766(-) AATAT(C/T)ATTGA intron-variant

Relevant External Links for NYAP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NYAP2 Gene

Disorders for NYAP2 Gene

No disorders were found for NYAP2 Gene.

No data available for UniProtKB/Swiss-Prot for NYAP2 Gene

Publications for NYAP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K. … Yamamoto T. (EMBO J. 2011) 2 3
  4. A genome-wide association study of early menopause and the combined impact of identified variants. (PMID: 23307926) Perry J.R. … Murray A. (Hum. Mol. Genet. 2013) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for NYAP2 Gene

Sources for NYAP2 Gene

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