Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NYAP2 Gene

Aliases for NYAP2 Gene

  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2 2 3 5
  • KIAA1486 2 3 4

External Ids for NYAP2 Gene

Previous HGNC Symbols for NYAP2 Gene

  • KIAA1486

Previous GeneCards Identifiers for NYAP2 Gene

  • GC02P226265

Summaries for NYAP2 Gene

GeneCards Summary for NYAP2 Gene

NYAP2 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 2) is a Protein Coding gene. An important paralog of this gene is NYAP1.

UniProtKB/Swiss-Prot for NYAP2 Gene

  • Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NYAP2 Gene

Genomics for NYAP2 Gene

Regulatory Elements for NYAP2 Gene

Enhancers for NYAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NYAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NYAP2 Gene

225,399,710 bp from pter
225,703,653 bp from pter
303,944 bases
Plus strand

Genomic View for NYAP2 Gene

Genes around NYAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NYAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NYAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYAP2 Gene

Proteins for NYAP2 Gene

  • Protein details for NYAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
    Protein Accession:
    Secondary Accessions:
    • A2RRN4
    • Q96NL2

    Protein attributes for NYAP2 Gene

    653 amino acids
    Molecular mass:
    70548 Da
    Quaternary structure:
    • Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
    • Sequence=BAA96010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYAP2 Gene


neXtProt entry for NYAP2 Gene

Proteomics data for NYAP2 Gene at MOPED

Post-translational modifications for NYAP2 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NYAP2 Gene

Domains & Families for NYAP2 Gene

Protein Domains for NYAP2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NYAP family.
  • Belongs to the NYAP family.
genes like me logo Genes that share domains with NYAP2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NYAP2 Gene

Function for NYAP2 Gene

Molecular function for NYAP2 Gene

UniProtKB/Swiss-Prot Function:
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

Phenotypes for NYAP2 Gene

GenomeRNAi human phenotypes for NYAP2:
genes like me logo Genes that share phenotypes with NYAP2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NYAP2 Gene

Localization for NYAP2 Gene

Subcellular locations from

Jensen Localization Image for NYAP2 Gene COMPARTMENTS Subcellular localization image for NYAP2 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NYAP2 Gene

Pathways & Interactions for NYAP2 Gene

SuperPathways for NYAP2 Gene

No Data Available

Interacting Proteins for NYAP2 Gene

Gene Ontology (GO) - Biological Process for NYAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048812 neuron projection morphogenesis ISS --
genes like me logo Genes that share ontologies with NYAP2: view

No data available for Pathways by source and SIGNOR curated interactions for NYAP2 Gene

Drugs & Compounds for NYAP2 Gene

No Compound Related Data Available

Transcripts for NYAP2 Gene

mRNA/cDNA for NYAP2 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NYAP2 Gene

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NYAP2 Gene

No ASD Table

Relevant External Links for NYAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NYAP2 Gene

mRNA expression in normal human tissues for NYAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NYAP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for NYAP2 Gene

This gene is overexpressed in Fetal Brain (38.9), Frontal cortex (16.6), and Heart (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NYAP2 Gene

SOURCE GeneReport for Unigene cluster for NYAP2 Gene Hs.224409

genes like me logo Genes that share expression patterns with NYAP2: view

Protein tissue co-expression partners for NYAP2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NYAP2 Gene

Orthologs for NYAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NYAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NYAP2 35
  • 86.65 (n)
  • 93.63 (a)
NYAP2 36
  • 87 (a)
(Canis familiaris)
Mammalia NYAP2 35
  • 85.25 (n)
  • 90.53 (a)
NYAP2 36
  • 81 (a)
(Mus musculus)
Mammalia Nyap2 35
  • 83.99 (n)
  • 91.42 (a)
Nyap2 16
Nyap2 36
  • 75 (a)
(Pan troglodytes)
Mammalia NYAP2 35
  • 99.18 (n)
  • 99.23 (a)
NYAP2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nyap2 35
  • 84.84 (n)
  • 91.9 (a)
(Monodelphis domestica)
Mammalia NYAP2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia NYAP2 36
  • 77 (a)
(Gallus gallus)
Aves NYAP2 35
  • 78.86 (n)
  • 84.46 (a)
NYAP2 36
  • 75 (a)
(Anolis carolinensis)
Reptilia NYAP2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nyap2 35
  • 70.68 (n)
  • 75.27 (a)
(Danio rerio)
Actinopterygii LOC100000797 35
  • 59.99 (n)
  • 61.63 (a)
NYAP2 (1 of 2) 36
  • 49 (a)
NYAP2 (2 of 2) 36
  • 28 (a)
Species with no ortholog for NYAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NYAP2 Gene

Gene Tree for NYAP2 (if available)
Gene Tree for NYAP2 (if available)

Paralogs for NYAP2 Gene

Paralogs for NYAP2 Gene

(1) SIMAP similar genes for NYAP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NYAP2: view

Variants for NYAP2 Gene

Sequence variations from dbSNP and Humsavar for NYAP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs7422680 - 225,582,030(+) TGAGC(A/G)CATCT reference, missense
rs3748993 - 225,627,054(+) CAGGG(A/C)CACCT reference, missense
rs715678 -- 225,600,693(+) TTCAT(C/T)CTTCC intron-variant
rs718659 -- 225,510,105(+) AAGAA(G/T)ATATG intron-variant
rs718660 -- 225,510,312(+) ACTCA(C/T)TAATG intron-variant

Variation tolerance for NYAP2 Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.93% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NYAP2 Gene

Disorders for NYAP2 Gene

Relevant External Links for NYAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NYAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NYAP2 Gene

Publications for NYAP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K. … Yamamoto T. (EMBO J. 2011) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A genome-wide association study of early menopause and the combined impact of identified variants. (PMID: 23307926) Perry J.R. … Murray A. (Hum. Mol. Genet. 2013) 3

Products for NYAP2 Gene

Sources for NYAP2 Gene