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Aliases for NYAP1 Gene

Aliases for NYAP1 Gene

  • Neuronal Tyrosine Phosphorylated Phosphoinositide-3-Kinase Adaptor 1 2 3
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 1 2 3 5
  • C7orf51 3 4
  • Chromosome 7 Open Reading Frame 51 2
  • KIAA1486-Like 2

External Ids for NYAP1 Gene

Previous HGNC Symbols for NYAP1 Gene

  • C7orf51
  • KIAA1486L

Previous GeneCards Identifiers for NYAP1 Gene

  • GC07P100082

Summaries for NYAP1 Gene

GeneCards Summary for NYAP1 Gene

NYAP1 (Neuronal Tyrosine Phosphorylated Phosphoinositide-3-Kinase Adaptor 1) is a Protein Coding gene. An important paralog of this gene is NYAP2.

UniProtKB/Swiss-Prot for NYAP1 Gene

  • Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NYAP1 Gene

Genomics for NYAP1 Gene

Regulatory Elements for NYAP1 Gene

Enhancers for NYAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NYAP1 on UCSC Golden Path with GeneCards custom track

Promoters for NYAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NYAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NYAP1 Gene

100,483,862 bp from pter
100,494,802 bp from pter
10,941 bases
Plus strand

Genomic View for NYAP1 Gene

Genes around NYAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NYAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NYAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYAP1 Gene

Proteins for NYAP1 Gene

  • Protein details for NYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
    Protein Accession:
    Secondary Accessions:
    • Q6U9Y3
    • Q8N1V0

    Protein attributes for NYAP1 Gene

    841 amino acids
    Molecular mass:
    87928 Da
    Quaternary structure:
    • Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
    • Sequence=BAC04437.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYAP1 Gene


neXtProt entry for NYAP1 Gene

Proteomics data for NYAP1 Gene at MOPED

Post-translational modifications for NYAP1 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NYAP1 Gene

Domains & Families for NYAP1 Gene

Protein Domains for NYAP1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NYAP family.
  • Belongs to the NYAP family.
genes like me logo Genes that share domains with NYAP1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NYAP1 Gene

Function for NYAP1 Gene

Molecular function for NYAP1 Gene

UniProtKB/Swiss-Prot Function:
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

Phenotypes for NYAP1 Gene

GenomeRNAi human phenotypes for NYAP1:
genes like me logo Genes that share phenotypes with NYAP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NYAP1 Gene

Localization for NYAP1 Gene

Subcellular locations from

Jensen Localization Image for NYAP1 Gene COMPARTMENTS Subcellular localization image for NYAP1 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NYAP1 Gene

Pathways & Interactions for NYAP1 Gene

SuperPathways for NYAP1 Gene

No Data Available

Interacting Proteins for NYAP1 Gene

Gene Ontology (GO) - Biological Process for NYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048812 neuron projection morphogenesis IEA,ISS --
genes like me logo Genes that share ontologies with NYAP1: view

No data available for Pathways by source and SIGNOR curated interactions for NYAP1 Gene

Drugs & Compounds for NYAP1 Gene

No Compound Related Data Available

Transcripts for NYAP1 Gene

mRNA/cDNA for NYAP1 Gene

Unigene Clusters for NYAP1 Gene

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NYAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6

Relevant External Links for NYAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NYAP1 Gene

mRNA expression in normal human tissues for NYAP1 Gene

mRNA differential expression in normal tissues according to GTEx for NYAP1 Gene

This gene is overexpressed in Brain - Cortex (x4.9), Brain - Frontal Cortex (BA9) (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for NYAP1 Gene

This gene is overexpressed in Breast (26.8), Esophagus (14.1), Heart (9.3), and Fetal Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NYAP1 Gene

SOURCE GeneReport for Unigene cluster for NYAP1 Gene Hs.320086

genes like me logo Genes that share expression patterns with NYAP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NYAP1 Gene

Orthologs for NYAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NYAP1 35
  • 90.45 (n)
  • 92.96 (a)
NYAP1 36
  • 93 (a)
(Canis familiaris)
Mammalia NYAP1 35
  • 91.61 (n)
  • 94.03 (a)
NYAP1 36
  • 93 (a)
(Mus musculus)
Mammalia Nyap1 35
  • 87.59 (n)
  • 92.53 (a)
Nyap1 16
Nyap1 36
  • 91 (a)
(Pan troglodytes)
Mammalia NYAP1 35
  • 99.37 (n)
  • 99.52 (a)
NYAP1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nyap1 35
  • 87.22 (n)
  • 92.31 (a)
(Monodelphis domestica)
Mammalia NYAP1 36
  • 76 (a)
(Anolis carolinensis)
Reptilia NYAP1 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486355 35
  • 58.63 (n)
  • 56.65 (a)
Species with no ortholog for NYAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NYAP1 Gene

Gene Tree for NYAP1 (if available)
Gene Tree for NYAP1 (if available)

Paralogs for NYAP1 Gene

Paralogs for NYAP1 Gene Pseudogenes for NYAP1 Gene

genes like me logo Genes that share paralogs with NYAP1: view

Variants for NYAP1 Gene

Sequence variations from dbSNP and Humsavar for NYAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6971558 -- 100,482,234(+) AGCCT(A/T)TAATA upstream-variant-2KB
rs6972167 -- 100,482,390(+) GTTTT(G/T)GTTTT upstream-variant-2KB
rs13224019 -- 100,493,877(+) AGCAC(A/T)CGGTC reference, missense
rs13224304 -- 100,493,863(+) GCCCT(A/G)CCGCC reference, missense
rs13229812 -- 100,483,088(+) CCGTA(C/G)CGGCC upstream-variant-2KB

Variation tolerance for NYAP1 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NYAP1 Gene

Disorders for NYAP1 Gene

Relevant External Links for NYAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NYAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NYAP1 Gene

Publications for NYAP1 Gene

  1. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K. … Yamamoto T. (EMBO J. 2011) 2 3 67
  2. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking D.E. … Newton-Cheh C. (Nat. Genet. 2014) 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3

Products for NYAP1 Gene

Sources for NYAP1 Gene