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Aliases for NYAP1 Gene

Aliases for NYAP1 Gene

  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 1 2 3
  • C7orf51 3 4
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adapter 1 3
  • Chromosome 7 Open Reading Frame 51 2
  • KIAA1486-Like 2
  • NYPA1 6

External Ids for NYAP1 Gene

Previous HGNC Symbols for NYAP1 Gene

  • C7orf51
  • KIAA1486L

Previous GeneCards Identifiers for NYAP1 Gene

  • GC07P100082

Summaries for NYAP1 Gene

GeneCards Summary for NYAP1 Gene

NYAP1 (Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 1) is a Protein Coding gene. An important paralog of this gene is NYAP2.

UniProtKB/Swiss-Prot for NYAP1 Gene

  • Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NYAP1 Gene

Genomics for NYAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NYAP1 Gene

Start:
100,483,869 bp from pter
End:
100,494,802 bp from pter
Size:
10,934 bases
Orientation:
Plus strand

Genomic View for NYAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NYAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYAP1 Gene

No data available for Regulatory Elements for NYAP1 Gene

Proteins for NYAP1 Gene

  • Protein details for NYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVC0-NYAP1_HUMAN
    Recommended name:
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
    Protein Accession:
    Q6ZVC0
    Secondary Accessions:
    • Q6U9Y3
    • Q8N1V0

    Protein attributes for NYAP1 Gene

    Size:
    841 amino acids
    Molecular mass:
    87928 Da
    Quaternary structure:
    • Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
    SequenceCaution:
    • Sequence=BAC04437.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NYAP1 Gene

Proteomics data for NYAP1 Gene at MOPED

Post-translational modifications for NYAP1 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NYAP1 Gene

Domains for NYAP1 Gene

Protein Domains for NYAP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6ZVC0

UniProtKB/Swiss-Prot:

NYAP1_HUMAN :
  • Q6ZVC0
Family:
  • Belongs to the NYAP family.
genes like me logo Genes that share domains with NYAP1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NYAP1 Gene

Function for NYAP1 Gene

Molecular function for NYAP1 Gene

UniProtKB/Swiss-Prot Function: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

Gene Ontology (GO) - Molecular Function for NYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NYAP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NYAP1 Gene

Localization for NYAP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NYAP1 Gene

Pathways for NYAP1 Gene

SuperPathways for NYAP1 Gene

No Data Available

Interacting Proteins for NYAP1 Gene

Gene Ontology (GO) - Biological Process for NYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014065 phosphatidylinositol 3-kinase signaling ISS --
GO:0048812 neuron projection morphogenesis ISS --
genes like me logo Genes that share ontologies with NYAP1: view

No data available for Pathways by source for NYAP1 Gene

Transcripts for NYAP1 Gene

mRNA/cDNA for NYAP1 Gene

(4) REFSEQ mRNAs :
(13) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NYAP1 Gene

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NYAP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NYAP1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NYAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3:

Relevant External Links for NYAP1 Gene

GeneLoc Exon Structure for
NYAP1
ECgene alternative splicing isoforms for
NYAP1

Expression for NYAP1 Gene

mRNA expression in normal human tissues for NYAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NYAP1 Gene

This gene is overexpressed in Brain - Cortex (4.9), Brain - Frontal Cortex (BA9) (4.4), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NYAP1 Gene

SOURCE GeneReport for Unigene cluster for NYAP1 Gene Hs.320086

genes like me logo Genes that share expressions with NYAP1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NYAP1 Gene

Orthologs for NYAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NYAP1 35
  • 99.37 (n)
  • 99.52 (a)
NYAP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NYAP1 35
  • 90.45 (n)
  • 92.96 (a)
NYAP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NYAP1 35
  • 91.61 (n)
  • 94.03 (a)
NYAP1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nyap1 35
  • 87.59 (n)
  • 92.53 (a)
Nyap1 16
Nyap1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NYAP1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nyap1 35
  • 87.22 (n)
  • 92.31 (a)
lizard
(Anolis carolinensis)
Reptilia NYAP1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486355 35
  • 58.63 (n)
  • 56.65 (a)
Species with no ortholog for NYAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NYAP1 Gene

ENSEMBL:
Gene Tree for NYAP1 (if available)
TreeFam:
Gene Tree for NYAP1 (if available)

Paralogs for NYAP1 Gene

Paralogs for NYAP1 Gene

Pseudogenes.org Pseudogenes for NYAP1 Gene

genes like me logo Genes that share paralogs with NYAP1: view

Variants for NYAP1 Gene

Sequence variations from dbSNP and Humsavar for NYAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2897358 -- 100,491,017(-) GAGGC(C/G)GAGCC reference, synonymous-codon
rs4388389 -- 100,492,908(+) aagaa(A/G)aaGag intron-variant
rs4727456 -- 100,492,558(+) CACCA(C/T)AGCAC intron-variant
rs6971558 -- 100,482,234(+) AGCCT(A/T)TAATA upstream-variant-2KB
rs6972167 -- 100,482,390(+) GTTTT(G/T)GTTTT upstream-variant-2KB

Relevant External Links for NYAP1 Gene

HapMap Linkage Disequilibrium report
NYAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NYAP1 Gene

Disorders for NYAP1 Gene

No disorders were found for NYAP1 Gene.

No data available for UniProtKB/Swiss-Prot for NYAP1 Gene

Publications for NYAP1 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K. … Yamamoto T. (EMBO J. 2011) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for NYAP1 Gene

Sources for NYAP1 Gene

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