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Aliases for NYAP1 Gene

Aliases for NYAP1 Gene

  • Neuronal Tyrosine Phosphorylated Phosphoinositide-3-Kinase Adaptor 1 2 3 5
  • C7orf51 3 4
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adaptor 1 2
  • Neuronal Tyrosine-Phosphorylated Phosphoinositide-3-Kinase Adapter 1 3
  • Chromosome 7 Open Reading Frame 51 2
  • KIAA1486-Like 2

External Ids for NYAP1 Gene

Previous HGNC Symbols for NYAP1 Gene

  • C7orf51
  • KIAA1486L

Previous GeneCards Identifiers for NYAP1 Gene

  • GC07P100082

Summaries for NYAP1 Gene

GeneCards Summary for NYAP1 Gene

NYAP1 (Neuronal Tyrosine Phosphorylated Phosphoinositide-3-Kinase Adaptor 1) is a Protein Coding gene. An important paralog of this gene is NYAP2.

UniProtKB/Swiss-Prot for NYAP1 Gene

  • Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

Additional gene information for NYAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NYAP1 Gene

Genomics for NYAP1 Gene

Regulatory Elements for NYAP1 Gene

Enhancers for NYAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H100514 1.1 Ensembl ENCODE 23.6 +31.9 31941 2.3 TBL1XR1 ZEB1 SCRT2 FOS ATF7 RUNX3 IKZF2 ZNF202 ZNF680 ZC3H11A SRRT ZSCAN25 GIGYF1 AP4M1 ENSG00000242798 STAG3L5P ZSCAN21 ZNF655 ZNF3 TRIM4
GH07H100538 2 FANTOM5 Ensembl ENCODE dbSUPER 12.6 +60.8 60752 12.6 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 GLIS1 RCOR2 SAP25 SRRT MEPCE PPP1R35 ZSCAN25 GIGYF1 AP4M1 PCOLCE-AS1 FBXO24 LRCH4
GH07H100438 1.7 FANTOM5 Ensembl ENCODE 12.4 -41.0 -41040 8 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF766 FOS PILRA C7orf61 TSC22D4 NYAP1 IRS3P SAP25 LRCH4 FBXO24 GPC2 PVRIG
GH07H101159 1.5 Ensembl ENCODE dbSUPER 12.5 +678.2 678232 5.5 PKNOX1 ARID4B SIN3A GLI4 ZNF121 GLIS2 FOS KLF7 SP3 TSHZ1 AP1S1 SRRT NAT16 PPP1R35 GIGYF1 ZCWPW1 STAG3L5P MEPCE PCOLCE-AS1 RN7SL750P
GH07H100493 1.3 Ensembl ENCODE dbSUPER 13.5 +10.1 10149 1.3 ELF3 CTCF TFAP4 ZNF792 RB1 SAP130 ARID4B RAD21 THRB KMT2B PILRA NYAP1 SAP25 GC07P100507
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NYAP1 on UCSC Golden Path with GeneCards custom track

Promoters for NYAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215800 -262 1201 HDGF ARNT ARID4B SIN3A ZBTB7B ZNF143 ZNF207 SP3 REST SMARCB1

Genomic Locations for NYAP1 Gene

Genomic Locations for NYAP1 Gene
chr7:100,483,862-100,494,802
(GRCh38/hg38)
Size:
10,941 bases
Orientation:
Plus strand
chr7:100,081,550-100,092,422
(GRCh37/hg19)

Genomic View for NYAP1 Gene

Genes around NYAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NYAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NYAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NYAP1 Gene

Proteins for NYAP1 Gene

  • Protein details for NYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVC0-NYAP1_HUMAN
    Recommended name:
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1
    Protein Accession:
    Q6ZVC0
    Secondary Accessions:
    • Q6U9Y3
    • Q8N1V0

    Protein attributes for NYAP1 Gene

    Size:
    841 amino acids
    Molecular mass:
    87928 Da
    Quaternary structure:
    • Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
    SequenceCaution:
    • Sequence=BAC04437.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NYAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NYAP1 Gene

Post-translational modifications for NYAP1 Gene

  • Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NYAP1 Gene

No data available for DME Specific Peptides for NYAP1 Gene

Domains & Families for NYAP1 Gene

Gene Families for NYAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NYAP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6ZVC0

UniProtKB/Swiss-Prot:

NYAP1_HUMAN :
  • Belongs to the NYAP family.
Family:
  • Belongs to the NYAP family.
genes like me logo Genes that share domains with NYAP1: view

No data available for Suggested Antigen Peptide Sequences for NYAP1 Gene

Function for NYAP1 Gene

Molecular function for NYAP1 Gene

UniProtKB/Swiss-Prot Function:
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

Phenotypes From GWAS Catalog for NYAP1 Gene

Phenotypes for NYAP1 Gene

GenomeRNAi human phenotypes for NYAP1:
genes like me logo Genes that share phenotypes with NYAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NYAP1 Gene

Localization for NYAP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NYAP1 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with NYAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NYAP1 Gene

Pathways & Interactions for NYAP1 Gene

SuperPathways for NYAP1 Gene

No Data Available

Interacting Proteins for NYAP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300179%0d%0a9606.ENSP00000293373%0d%0a
Selected Interacting proteins: ENSP00000300179 Q6ZVC0-NYAP1_HUMAN for NYAP1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014065 phosphatidylinositol 3-kinase signaling IEA,ISS --
GO:0048812 neuron projection morphogenesis IEA,ISS --
genes like me logo Genes that share ontologies with NYAP1: view

No data available for Pathways by source and SIGNOR curated interactions for NYAP1 Gene

Drugs & Compounds for NYAP1 Gene

No Compound Related Data Available

Transcripts for NYAP1 Gene

mRNA/cDNA for NYAP1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NYAP1 Gene

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NYAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2:
SP3:

Relevant External Links for NYAP1 Gene

GeneLoc Exon Structure for
NYAP1
ECgene alternative splicing isoforms for
NYAP1

Expression for NYAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NYAP1 Gene

mRNA differential expression in normal tissues according to GTEx for NYAP1 Gene

This gene is overexpressed in Brain - Cortex (x4.9), Brain - Frontal Cortex (BA9) (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for NYAP1 Gene

This gene is overexpressed in Breast (26.8), Esophagus (14.1), Heart (9.3), and Fetal Brain (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NYAP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NYAP1 Gene:

NYAP1

SOURCE GeneReport for Unigene cluster for NYAP1 Gene:

Hs.320086

Evidence on tissue expression from TISSUES for NYAP1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NYAP1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NYAP1 Gene

Orthologs for NYAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NYAP1 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia NYAP1 33 34
  • 91.61 (n)
cow
(Bos Taurus)
Mammalia NYAP1 33 34
  • 90.45 (n)
mouse
(Mus musculus)
Mammalia Nyap1 33 16 34
  • 87.59 (n)
rat
(Rattus norvegicus)
Mammalia Nyap1 33
  • 87.22 (n)
oppossum
(Monodelphis domestica)
Mammalia NYAP1 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NYAP1 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486355 33
  • 58.63 (n)
Species where no ortholog for NYAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NYAP1 Gene

ENSEMBL:
Gene Tree for NYAP1 (if available)
TreeFam:
Gene Tree for NYAP1 (if available)

Paralogs for NYAP1 Gene

Paralogs for NYAP1 Gene

Pseudogenes.org Pseudogenes for NYAP1 Gene

genes like me logo Genes that share paralogs with NYAP1: view

Variants for NYAP1 Gene

Sequence variations from dbSNP and Humsavar for NYAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000423028 -- 100,493,116(+) TGAGA(C/G)GATCC intron-variant
rs1000513451 -- 100,482,034(+) GGCGT(C/T)TCATC upstream-variant-2KB
rs1000780836 -- 100,492,741(+) AAAAA(A/G)TTTAA intron-variant
rs1000800040 -- 100,490,242(+) GCTGC(A/G)GTTGG intron-variant, reference, missense
rs1000868194 -- 100,488,785(+) GGTCT(C/T)AAGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NYAP1 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv527050 CNV loss 19592680
nsv951385 CNV deletion 24416366
nsv831071 CNV loss 17160897

Variation tolerance for NYAP1 Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NYAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NYAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NYAP1 Gene

Disorders for NYAP1 Gene

Relevant External Links for NYAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NYAP1

No disorders were found for NYAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NYAP1 Gene

Publications for NYAP1 Gene

  1. NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. (PMID: 21946561) Yokoyama K … Yamamoto T (The EMBO journal 2011) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 60
  4. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking DE … Newton-Cheh C (Nature genetics 2014) 3 60
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 60

Products for NYAP1 Gene

Sources for NYAP1 Gene

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