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Aliases for NXT2 Gene

Aliases for NXT2 Gene

  • Nuclear Transport Factor 2-Like Export Factor 2 2 3
  • Protein P15-2 3 4
  • NTF2-Related Export Protein 2 3
  • P15-2 3

External Ids for NXT2 Gene

Previous GeneCards Identifiers for NXT2 Gene

  • GC0XP105925
  • GC0XP106804
  • GC0XP107542
  • GC0XP108585
  • GC0XP108665
  • GC0XP108780
  • GC0XP098400

Summaries for NXT2 Gene

Entrez Gene Summary for NXT2 Gene

  • The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NXT2 Gene

NXT2 (Nuclear Transport Factor 2-Like Export Factor 2) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. An important paralog of this gene is NXT1.

UniProtKB/Swiss-Prot for NXT2 Gene

  • Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXT2 Gene

Genomics for NXT2 Gene

Regulatory Elements for NXT2 Gene

Genomic Location for NXT2 Gene

Start:
109,535,781 bp from pter
End:
109,544,698 bp from pter
Size:
8,918 bases
Orientation:
Plus strand

Genomic View for NXT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXT2 Gene

Proteins for NXT2 Gene

  • Protein details for NXT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPJ8-NXT2_HUMAN
    Recommended name:
    NTF2-related export protein 2
    Protein Accession:
    Q9NPJ8
    Secondary Accessions:
    • D3DUY1
    • Q0VAN8
    • Q5JYV5
    • Q5JYV6
    • Q5JYV7
    • Q9H8U0
    • Q9NQ64
    • Q9NRL7
    • Q9Y3M4
    • Q9Y3M5

    Protein attributes for NXT2 Gene

    Size:
    142 amino acids
    Molecular mass:
    16228 Da
    Quaternary structure:
    • Associates with NXF1, NXF2, NXF3 and NXF5
    SequenceCaution:
    • Sequence=BAB14511.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NXT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXT2 Gene

Proteomics data for NXT2 Gene at MOPED

Post-translational modifications for NXT2 Gene

  • Ubiquitination at Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for NXT2 Gene

No data available for DME Specific Peptides for NXT2 Gene

Domains for NXT2 Gene

Protein Domains for NXT2 Gene

Suggested Antigen Peptide Sequences for NXT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPJ8

UniProtKB/Swiss-Prot:

NXT2_HUMAN :
  • Q9NPJ8
Domain:
  • Contains 1 NTF2 domain.
genes like me logo Genes that share domains with NXT2: view

No data available for Gene Families for NXT2 Gene

Function for NXT2 Gene

Molecular function for NXT2 Gene

UniProtKB/Swiss-Prot Function: Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export

Gene Ontology (GO) - Molecular Function for NXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NXT2: view

Phenotypes for NXT2 Gene

GenomeRNAi human phenotypes for NXT2:
genes like me logo Genes that share phenotypes with NXT2: view

Animal Model Products

CRISPR Products

miRNA for NXT2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NXT2 Gene

Localization for NXT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXT2 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXT2 Gene COMPARTMENTS Subcellular localization image for NXT2 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NXT2: view

Pathways for NXT2 Gene

genes like me logo Genes that share pathways with NXT2: view

Pathways by source for NXT2 Gene

Gene Ontology (GO) - Biological Process for NXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0015031 protein transport IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with NXT2: view

Transcripts for NXT2 Gene

Unigene Clusters for NXT2 Gene

Nuclear transport factor 2-like export factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXT2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for NXT2 Gene

GeneLoc Exon Structure for
NXT2
ECgene alternative splicing isoforms for
NXT2

Expression for NXT2 Gene

mRNA expression in normal human tissues for NXT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NXT2 Gene

SOURCE GeneReport for Unigene cluster for NXT2 Gene Hs.25010

genes like me logo Genes that share expressions with NXT2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NXT2 Gene

Orthologs for NXT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473728 35
  • 90.31 (n)
  • 86.73 (a)
NXT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NXT2 35
  • 92.2 (n)
  • 90.07 (a)
NXT2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXT2 35
  • 87.48 (n)
  • 79.19 (a)
NXT2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nxt2 35
  • 87.71 (n)
  • 87.94 (a)
Nxt2 16
Nxt2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NXT2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxt2 35
  • 87.23 (n)
  • 87.94 (a)
chicken
(Gallus gallus)
Aves NXT2 35
  • 78.01 (n)
  • 88.65 (a)
NXT2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NXT2 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68570 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nxt2 35
  • 70.74 (n)
  • 71.94 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8809 35
zebrafish
(Danio rerio)
Actinopterygii nxt2 35
  • 67.86 (n)
  • 72.32 (a)
nxt2 36
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nxt1 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nxt-1 36
  • 30 (a)
OneToMany
Species with no ortholog for NXT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXT2 Gene

ENSEMBL:
Gene Tree for NXT2 (if available)
TreeFam:
Gene Tree for NXT2 (if available)

Paralogs for NXT2 Gene

Paralogs for NXT2 Gene

Selected SIMAP similar genes for NXT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXT2: view

Variants for NXT2 Gene

Sequence variations from dbSNP and Humsavar for NXT2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1321289 -- 109,544,744(-) AGTAA(C/T)CATTC downstream-variant-500B
rs3204027 -- 109,543,785(+) TTAAA(C/T)TTTAA utr-variant-3-prime
rs3761511 -- 109,536,514(-) CGTGC(A/G)TGACT upstream-variant-2KB, intron-variant
rs3827420 -- 109,535,288(-) CTGAC(C/T)ATTCC upstream-variant-2KB
rs3834689 -- 109,534,457(-) CTGCC(-/C)TTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NXT2 Gene

Variant ID Type Subtype PubMed ID
dgv2463e1 CNV Complex 17122850

Relevant External Links for NXT2 Gene

HapMap Linkage Disequilibrium report
NXT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXT2 Gene

Disorders for NXT2 Gene

(1) University of Copenhagen DISEASES for NXT2 Gene

genes like me logo Genes that share disorders with NXT2: view

No data available for UniProtKB/Swiss-Prot for NXT2 Gene

Publications for NXT2 Gene

  1. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PMID: 11073998) Herold A. … Izaurralde E. (Mol. Cell. Biol. 2000) 2 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for NXT2 Gene

Sources for NXT2 Gene

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