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Aliases for NXT2 Gene

Aliases for NXT2 Gene

  • Nuclear Transport Factor 2 Like Export Factor 2 2 3 5
  • Protein P15-2 3 4
  • Nuclear Transport Factor 2-Like Export Factor 2 2
  • NTF2-Related Export Protein 2 3
  • P15-2 3

External Ids for NXT2 Gene

Previous GeneCards Identifiers for NXT2 Gene

  • GC0XP105925
  • GC0XP106804
  • GC0XP107542
  • GC0XP108585
  • GC0XP108665
  • GC0XP108780
  • GC0XP098400

Summaries for NXT2 Gene

Entrez Gene Summary for NXT2 Gene

  • The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NXT2 Gene

NXT2 (Nuclear Transport Factor 2 Like Export Factor 2) is a Protein Coding gene. Diseases associated with NXT2 include Diversion Colitis. Among its related pathways are mRNA surveillance pathway and Ribosome biogenesis in eukaryotes. An important paralog of this gene is NXT1.

UniProtKB/Swiss-Prot for NXT2 Gene

  • Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.

Additional gene information for NXT2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXT2 Gene

Genomics for NXT2 Gene

Regulatory Elements for NXT2 Gene

Enhancers for NXT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH109774 1.1 Ensembl ENCODE 12.1 +239.0 238980 1 RAD21 BATF RARA TCF12 FOS ETV6 ATF7 RUNX3 CREM IKZF2 NXT2 ENSG00000252069 GC0XM109745 RPS5P7
GH0XH109839 1.5 FANTOM5 Ensembl ENCODE 7 +305.3 305259 2 ATF1 NFRKB FEZF1 TCF12 GLIS2 EGR1 FOS IKZF2 CREM EGR2 ACSL4 NXT2 RPS5P7 ENSG00000252069 GC0XM109745
GH0XH109829 1.5 FANTOM5 Ensembl ENCODE 6.5 +295.2 295164 2 ELF3 FOXA2 RARA CREM HMG20B ELF1 PPARG KAT8 SREBF1 NFIL3 NXT2 RPS5P7 ENSG00000252069 GC0XM109745
GH0XH109773 0.7 FANTOM5 ENCODE 12.1 +237.8 237770 0 RUNX3 CREM ACSL4 NXT2 ENSG00000252069 GC0XM109745 RPS5P7
GH0XH109739 1.6 FANTOM5 Ensembl ENCODE 4.8 +204.4 204368 1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 ATF7 SP5 PPARG KAT8 NXT2 TMEM164 GC0XM109745 ENSG00000252069 ACSL4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NXT2 on UCSC Golden Path with GeneCards custom track

Promoters for NXT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247931 1420 2000 PKNOX1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 SP3

Genomic Location for NXT2 Gene

Chromosome:
X
Start:
109,535,781 bp from pter
End:
109,544,698 bp from pter
Size:
8,918 bases
Orientation:
Plus strand

Genomic View for NXT2 Gene

Genes around NXT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXT2 Gene

Proteins for NXT2 Gene

  • Protein details for NXT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPJ8-NXT2_HUMAN
    Recommended name:
    NTF2-related export protein 2
    Protein Accession:
    Q9NPJ8
    Secondary Accessions:
    • D3DUY1
    • Q0VAN8
    • Q5JYV5
    • Q5JYV6
    • Q5JYV7
    • Q9H8U0
    • Q9NQ64
    • Q9NRL7
    • Q9Y3M4
    • Q9Y3M5

    Protein attributes for NXT2 Gene

    Size:
    142 amino acids
    Molecular mass:
    16228 Da
    Quaternary structure:
    • Associates with NXF1, NXF2, NXF3 and NXF5.
    SequenceCaution:
    • Sequence=BAB14511.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NXT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXT2 Gene

Post-translational modifications for NXT2 Gene

  • Ubiquitination at posLast=106106
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NXT2 Gene

Domains & Families for NXT2 Gene

Gene Families for NXT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NXT2 Gene

Suggested Antigen Peptide Sequences for NXT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NXT2: view

No data available for UniProtKB/Swiss-Prot for NXT2 Gene

Function for NXT2 Gene

Molecular function for NXT2 Gene

UniProtKB/Swiss-Prot Function:
Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.

Gene Ontology (GO) - Molecular Function for NXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NXT2: view
genes like me logo Genes that share phenotypes with NXT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NXT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXT2 Gene

Localization for NXT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXT2 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXT2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NXT2: view

Pathways & Interactions for NXT2 Gene

genes like me logo Genes that share pathways with NXT2: view

Pathways by source for NXT2 Gene

Gene Ontology (GO) - Biological Process for NXT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with NXT2: view

No data available for SIGNOR curated interactions for NXT2 Gene

Drugs & Compounds for NXT2 Gene

No Compound Related Data Available

Transcripts for NXT2 Gene

Unigene Clusters for NXT2 Gene

Nuclear transport factor 2-like export factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NXT2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NXT2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for NXT2 Gene

GeneLoc Exon Structure for
NXT2
ECgene alternative splicing isoforms for
NXT2

Expression for NXT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NXT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NXT2 Gene

This gene is overexpressed in Ovary (24.1), Bone (21.8), Peripheral blood mononuclear cells (6.2), and Placenta (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NXT2 Gene



NURSA nuclear receptor signaling pathways regulating expression of NXT2 Gene:

NXT2

SOURCE GeneReport for Unigene cluster for NXT2 Gene:

Hs.25010

Evidence on tissue expression from TISSUES for NXT2 Gene

  • Bone marrow(4.2)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with NXT2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXT2 Gene

Orthologs for NXT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXT2 34
  • 99 (a)
OneToOne
LOC473728 33
  • 90.31 (n)
cow
(Bos Taurus)
Mammalia NXT2 33 34
  • 92.2 (n)
mouse
(Mus musculus)
Mammalia Nxt2 33 16 34
  • 87.71 (n)
dog
(Canis familiaris)
Mammalia NXT2 33 34
  • 87.48 (n)
rat
(Rattus norvegicus)
Mammalia Nxt2 33
  • 87.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NXT2 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves NXT2 33 34
  • 78.01 (n)
lizard
(Anolis carolinensis)
Reptilia NXT2 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxt2 33
  • 70.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68570 33
zebrafish
(Danio rerio)
Actinopterygii nxt2 33 34
  • 67.86 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8809 33
fruit fly
(Drosophila melanogaster)
Insecta Nxt1 34
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nxt-1 34
  • 30 (a)
OneToMany
Species where no ortholog for NXT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXT2 Gene

ENSEMBL:
Gene Tree for NXT2 (if available)
TreeFam:
Gene Tree for NXT2 (if available)

Paralogs for NXT2 Gene

Paralogs for NXT2 Gene

(1) SIMAP similar genes for NXT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXT2: view

Variants for NXT2 Gene

Sequence variations from dbSNP and Humsavar for NXT2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000139108 -- 109,537,304(+) TCTCT(C/T)GATTA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000298598 -- 109,540,024(+) GAAGG(A/G)GTCCA intron-variant
rs1001050667 -- 109,539,874(+) TTTGG(G/T)TTTTA intron-variant
rs1001627280 -- 109,538,704(+) CTGCA(C/T)CATAT intron-variant
rs1001923401 -- 109,540,411(+) CAACC(A/T)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXT2 Gene

Variant ID Type Subtype PubMed ID
esv2758883 CNV loss 17122850

Variation tolerance for NXT2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXT2 Gene

Disorders for NXT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NXT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diversion colitis
- elite association - COSMIC cancer census association via MalaCards
Search NXT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NXT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXT2
genes like me logo Genes that share disorders with NXT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXT2 Gene

Publications for NXT2 Gene

  1. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PMID: 11073998) Herold A … Izaurralde E (Molecular and cellular biology 2000) 2 3 4 22 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 60

Products for NXT2 Gene

Sources for NXT2 Gene

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