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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXT2 Gene

protein-coding   GIFtS: 56
GCID: GC0XP108780

nuclear transport factor 2-like export factor 2

 Explore 3 diseases affiliated with
NXT2 via our new
 Human Malady Compendium 
Biological research products
for NXT2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nuclear Transport Factor 2-Like Export Factor 21 2
P15-21 2
Protein P15-22 3
NTF2-Related Export Protein 22

External Ids:    HGNC: 181511   Entrez Gene: 559162   Ensembl: ENSG000001018887   OMIM: 3003205   UniProtKB: Q9NPJ83   

Export aliases for NXT2 gene to outside databases

Previous GC identifers: GC0XP105925 GC0XP106804 GC0XP107542 GC0XP108585 GC0XP108665 GC0XP098400


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NXT2:
The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in
the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also
have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been
noted for this gene. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: NXT2_HUMAN, Q9NPJ8
Function: Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NXT2 gene promoter:
         Sp1   Nkx2-5   RORalpha2   C/EBPalpha   GATA-1   S8   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NXT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NXT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq22.3

NXT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXT2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP108780:  view genomic region     (about GC identifiers)

Start:
108,779,010 bp from pter      End:
108,787,919 bp from pter
Size:
8,910 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NXT2_HUMAN, Q9NPJ8 (See protein sequence)
Recommended Name: NTF2-related export protein 2  
Size: 142 amino acids; 16228 Da
Subunit: Associates with NXF1, NXF2, NXF3 and NXF5
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm
Sequence caution: Sequence=BAB14511.1; Type=Erroneous initiation;
Secondary accessions: D3DUY1 Q0VAN8 Q5JYV5 Q5JYV6 Q5JYV7 Q9H8U0 Q9NQ64 Q9NRL7 Q9Y3M4 Q9Y3M5
Alternative splicing: 4 isoforms:  Q9NPJ8-1   Q9NPJ8-2   Q9NPJ8-3   Q9NPJ8-4   (Incomplete sequence)

Explore the universe of human proteins at neXtProt for NXT2: NX_Q9NPJ8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NPJ8

  • NXT2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229546.1  NP_001229547.1  NP_061168.2  

    ENSEMBL proteins: 
     ENSP00000218004   ENSP00000361179   ENSP00000361178   ENSP00000361175  

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    ProSpec Recombinant Protein for NXT2
    Uscn Proteins for NXT2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    NXT2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NXT2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002075 NTF2
     IPR018222 Nuclear_transport_factor_2_euk

    Graphical View of Domain Structure for InterPro Entry Q9NPJ8

    ProtoNet protein and cluster: Q9NPJ8

    1 Blocks protein family: IPB002075 Nuclear transport factor 2 (NTF2)

    UniProtKB/Swiss-Prot: NXT2_HUMAN, Q9NPJ8
    Similarity: Contains 1 NTF2 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NXT2_HUMAN, Q9NPJ8
    Function: Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export

    miRNA
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    miRTarBase miRNAs that target NXT2:
    hsa-let-7b (MIRT005043)

    OriGene 3'-UTR Clone: NXT2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXT2
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate NXT2 (see all 44):
    hsa-let-7d hsa-miR-128 hsa-miR-624* hsa-miR-218 hsa-let-7g hsa-miR-124 hsa-let-7a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidNXT2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXT2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    NXT2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NXT2:
     Decreased viability with pacli 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA surveillance pathway
    mRNA surveillance pathway1.00
    2Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes1.00
    3RNA transport
    RNA transport1.00
    4Measles
    Influenza A0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    4         Kegg Pathways  (Kegg details for NXT2):
        Ribosome biogenesis in eukaryotes
    RNA transport
    mRNA surveillance pathway
    Influenza A


    NXT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/10 Interacting proteins for NXT2 (Q9NPJ82, 3 ENSP000002180044) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF3Q9H4D53, ENSP000003785044I2D: score=5 STRING: ENSP00000378504
    NXF1Q9UBU93, ENSP000002941724I2D: score=2 STRING: ENSP00000294172
    AKR7A3O951543I2D: score=1 
    NUP98ENSP000003160324STRING: ENSP00000316032
    NXF5ENSP000002630324STRING: ENSP00000263032
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0051028mRNA transport IEA--


    NXT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXT2
    Search CenterWatch for drugs/clinical trials and news about NXT2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NXT2 gene (3 alternative transcripts): 
    NM_001242617.1  NM_001242618.1  NM_018698.4  

    Unigene Cluster for NXT2:

    Nuclear transport factor 2-like export factor 2
    Hs.25010  [show with all ESTs]
    Unigene Representative Sequence: NM_018698
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000218004(uc004eoe.2) ENST00000372107 ENST00000372106(uc004eof.2 uc004eog.2)
    ENST00000372103

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    hsa-let-7d hsa-miR-128 hsa-miR-624* hsa-miR-218 hsa-let-7g hsa-miR-124 hsa-let-7a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidNXT2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXT2
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    Additional cDNA sequence: 

    AF201942.1 AF212223.1 AF246127.1 AJ277591.1 AJ278323.1 AK023289.1 BC014888.1 BC120984.1 
    BC120985.1 

    5 DOTS entries:

    DT.313130  DT.92424216  DT.101979773  DT.95187453  DT.121307518 

    24/122 AceView cDNA sequences (see all 122):

    AA757334 AF246127 NM_018698 AA234442 BE887056 CB126767 AL707165 CB148705 
    AV716990 AI554438 AK023289 AA328722 AU133525 BF109045 AJ277591 BM975751 
    AA459145 AA236578 AF201942 AF212223 AJ278323 AW673772 AA354023 AI682474 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NXT2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
    SP1:        -     -           -                                 
    SP2:                          -                                 
    SP3:                          -                                 
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for NXT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCCTATTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NXT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXT2

    SOURCE GeneReport for Unigene cluster: Hs.25010
        SABiosciences Custom PCR Arrays for NXT2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NXT2 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NXT21 nuclear transport factor 2-like export factor 2 78.01(n)
    88.65(a)
      422346  NM_001006436.1  NP_001006436.1 
    lizard
    (Anolis carolinensis)
    Reptilia NXT26
    --
    78(a)
    1 → many
    GL343202.1(4342702-4344655)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685702 NTF2-like export factor 1 73.93(n)    BC058202.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nxt21 nuclear transport factor 2-like export factor 2 67.86(n)
    72.32(a)
      751738  NM_001045448.1  NP_001038913.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nxt16
    NTF2-related export protein 1
    41(a)
    1 → many
    2R(19698844-19699496)
    worm
    (Caenorhabditis elegans)
    Secernentea nxt-16
    NTF2-related export protein
    24(a)
    1 → many
    I(2929779-2931363)


    ENSEMBL Gene Tree for NXT2 (if available)
    TreeFam Gene Tree for NXT2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXT2 gene
    NXT12  
    1 SIMAP similar gene for NXT2 using alignment to 1 protein entry:     NXT2_HUMAN:
    NXT1

    NXT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 NCBI SNPs in NXT2 are shown (see all 104    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs128490141,2
    C,H--98399262(+) ACCCTC/GCCATA 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs65682621,2
    C,A,--98399892(+) agaagC/Tggggg 2 -- us2k12Minor allele frequency- T:0.25WA 4
    rs65682631,2
    C,F,A,H,--98400003(+) TTAGCC/TGGACG 2 -- us2k112Minor allele frequency- T:0.18NS EA NA WA 1422
    rs736391321,2
    C,--98400764(+) GCTGAA/GAAGAA 3 -- us2k1 ut511Minor allele frequency- G:0.00WA 2
    rs66434481,2
    C,H--98403684(+) TGGTCA/GAGTGA 3 -- int16Minor allele frequency- G:0.00NS EA NA 424
    rs735322501,2
    C,--98403803(+) AACCCG/ATTTAT 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1125965671,2
    C,--98404897(+) TTAATT/CCATCT 3 -- int11Minor allele frequency- C:0.00CSA 1
    rs128510771,2
    C,H--98405032(+) GGTGAA/TAACCA 3 -- int14Minor allele frequency- T:0.00NS EA 420
    rs594694181,2
    C,--98406799(+) GGGAAG/AGATTA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1134919081,2
    C,--98407048(+) TTTTCC/TTTTAT 3 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for NXT2 (108779010 - 108787919 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NXT2
         1 CNV: 4163

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    DNA2.0 Custom Variant and Variant Library Synthesis for NXT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NXT2 for disorders           About GeneDecksing

    OMIM gene information: 300320    OMIM disorders: --

    3 diseases for NXT2:    About MalaCards
    cri-du-chat syndrome    wolf-hirschhorn syndrome    influenza


    Export disorders for NXT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXT2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with NXT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PubMed id 11073998)1, 2, 3, 9 Herold A.... Izaurralde E. (2000)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55916 HGNC: 18151 AceView: NXT2 Ensembl:ENSG00000101888 euGenes: HUgn55916
    ECgene: NXT2 Kegg: 55916 H-InvDB: NXT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NXT2 gene:
    Search GeneIP for patents involving NXT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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