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NXT1 Gene

protein-coding   GIFtS: 55
GCID: GC20P023331

NTF2-Like Export Factor 1

(Previous name: NTX2-like export factor1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NTF2-Like Export Factor 11 2     P152
NTX2-Like Export Factor11 2     NTF2-Related Export Protein 12
Protein P152 3     NUTF-Like Export Factor 12
MTR22 5     

External Ids:    HGNC: 159131   Entrez Gene: 291072   Ensembl: ENSG000001326617   OMIM: 6058115   UniProtKB: Q9UKK63   

Export aliases for NXT1 gene to outside databases

Previous GC identifers: GC20P023319 GC20P023326 GC20P023279


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NXT1 Gene:
The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear
transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)-
and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of
U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The
encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear
mRNA export. The use of alternate polyadenylation sites has been found for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for NXT1 Gene:
NXT1 (NTF2-like export factor 1) is a protein-coding gene. Diseases associated with NXT1 include conjunctivitis, and influenza. GO annotations related to this gene include Ran GTPase binding. An important paralog of this gene is NXT2.

UniProtKB/Swiss-Prot: NXT1_HUMAN, Q9UKK6
Function: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1
snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with
ALYREF/THOC4 and THOC5

Gene Wiki entry for NXT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the NXT1 gene promoter:
         Elk-1   p53   Cdc5   POU3F2   Max   E2F-1   E2F   ZIC2/Zic2   Zic3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXT1 promoter sequence
   Search Chromatin IP Primers for NXT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NXT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12-p11.2   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p12-p11.2

NXT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXT1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P023331:  view genomic region     (about GC identifiers)

Start:
23,331,373 bp from pter      End:
23,335,414 bp from pter
Size:
4,042 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NXT1_HUMAN, Q9UKK6 (See protein sequence)
Recommended Name: NTF2-related export protein 1  
Size: 140 amino acids; 15847 Da
Subunit: Heterodimer with NXF1. Interacts (via NTF2 domain) with NXF1. Stablizes the NTF2 domain of NXF1 by
heterodimerization. The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA
export. Preferentially binds Ran-GTP. Associates with NXF2, NXF3 and NXF5. Does not bind nucleoporins (NPC)
directly, its association to NPC is mediated by NXF1
2 PDB 3D structures from and Proteopedia for NXT1:
1JKG (3D)        1JN5 (3D)    

Explore the universe of human proteins at neXtProt for NXT1: NX_Q9UKK6

Explore proteomics data for NXT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys30
  • Modification sites at PhosphoSitePlus

  • See NXT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037380.1  
    ENSEMBL proteins: 
     ENSP00000254998  

    NXT1 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for NXT1
    Cloud-Clone Corp. Proteins for NXT1

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    NXT1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NXT1
    Cloud-Clone Corp. CLIAs for NXT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002075 NTF2
     IPR018222 Nuclear_transport_factor_2_euk

    Graphical View of Domain Structure for InterPro Entry Q9UKK6

    ProtoNet protein and cluster: Q9UKK6

    1 Blocks protein domain: IPB002075 Nuclear transport factor 2 (NTF2)

    UniProtKB/Swiss-Prot: NXT1_HUMAN, Q9UKK6
    Similarity: Contains 1 NTF2 domain


    NXT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXT1_HUMAN, Q9UKK6
    Function: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1
    snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with
    ALYREF/THOC4 and THOC5

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11566096
    GO:0008536Ran GTPase binding IEA--
         
    NXT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NXT1:
     Increased G1 DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NXT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NXT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NXT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NXT1:
    hsa-mir-128-3p (MIRT021904), hsa-mir-30a-5p (MIRT028425), hsa-mir-331-3p (MIRT043373), hsa-mir-320a (MIRT044814)

    Block miRNA regulation of human, mouse, rat NXT1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NXT1:
    hsa-miR-525-5p hsa-miR-3121-3p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidNXT1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NXT1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NXT1 (NM_013248)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXT1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NXT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NXT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NXT1_HUMAN, Q9UKK6: Nucleus. Nucleus speckle (Probable). Cytoplasm. Note=Shuttles between the nucleus and the
    cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005643nuclear pore IEA--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IEA--

    NXT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NXT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34
    2RNA transport
    RNA transport
    3Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes
    4mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Kegg Pathways  (Kegg details for NXT1):
        Ribosome biogenesis in eukaryotes
    RNA transport
    mRNA surveillance pathway
    Influenza A


    NXT1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NXT1
    Interactions:

        GeneGlobe Interaction Network for NXT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NXT1 (Q9UKK61, 2, 3 ENSP000002549984) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU91, 2, 3, ENSP000002941724EBI-301889,EBI-398874 MINT-25019 I2D: score=8 STRING: ENSP00000294172
    NXF3Q9H4D51, 3, ENSP000003785044EBI-301889,EBI-750038 I2D: score=4 STRING: ENSP00000378504
    RANP628263, ENSP000003961274I2D: score=1 STRING: ENSP00000396127
    ALYREFQ86V812, ENSP000003318174MINT-7040261 STRING: ENSP00000331817
    PRKAB1Q9Y4783, ENSP000002293284I2D: score=1 STRING: ENSP00000229328
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006405RNA export from nucleus IEA--
    GO:0006611protein export from nucleus IEA--
    GO:0006810transport ----

    NXT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NXT1

    1 HMDB Compound for NXT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for NXT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leptomycin b 81.1 2 10567585 (1), 12743041 (1)



    NXT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NXT1 gene: 
    NM_013248.2  

    Unigene Cluster for NXT1:

    NTF2-like export factor 1
    Hs.516933  [show with all ESTs]
    Unigene Representative Sequence: BM809200
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000254998(uc002wsx.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat NXT1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NXT1:
    hsa-miR-525-5p hsa-miR-3121-3p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidNXT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NXT1
    Predesigned siRNA for gene silencing in human, mouse, rat NXT1
    Clone
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    OriGene clones in human, mouse for NXT1 (see all 7)
    OriGene ORF clones in mouse, rat for NXT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NXT1 (NM_013248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXT1
    Primer
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    OriGene qPCR primer pairs and template standards for NXT1
    OriGene qSTAR qPCR primer pairs in human, mouse for NXT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXT1
      QuantiTect SYBR Green Assays in human, mouse, rat NXT1
      QuantiFast Probe-based Assays in human, mouse, rat NXT1

    Additional mRNA sequence: 

    AF156957.1 AK026360.1 BC000759.2 BC002687.2 BC003029.1 BC003410.1 

    3 DOTS entries:

    DT.314295  DT.95370113  DT.120773750 

    Selected AceView cDNA sequences (see all 126):

    AK026360 BQ937662 AI167905 NM_013248 BU521391 BM675619 BC002687 BG109830 
    BQ187897 AA223284 BQ581596 AW082583 BM789812 BX113437 AI206974 AI479307 
    BE893090 BM552305 BU602316 BI913135 AW246842 AW274482 AA872518 CB305847 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NXT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCTTCTTA
    NXT1 Expression
    About this image

    NXT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NXT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516933
        Custom PCR Arrays for NXT1
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    QuantiFast Probe-based Assays in human, mouse, rat NXT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NXT1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxt11 , 5 NTF2-related export protein 11, 5 91.43(n)1
    98.57(a)1
      2 (73.53 cM)5
    564881  NM_001110159.11  NP_001103629.11 
     1486726015 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.18562 Transcribed sequence with moderate similarity to protein more 75.84(n)    137720472 
    zebrafish
    (Danio rerio)
    Actinopterygii nxt26
    nuclear transport factor 2-like export factor 2
    71(a)
    1 → many
    14(29479556-29484083) ENSDARG00000061527
    fruit fly
    (Drosophila melanogaster)
    Insecta Nxt11 NTF2-related export protein 1 52.2(n)
    42.64(a)
      37769  NM_137989.2  NP_611833.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nxt-16
    Protein NXT-1, isoform a (nxt-1) mRNA, complete cd...
    29(a)
    1 → many
    I(2929777-2931361) WBGene00003836


    ENSEMBL Gene Tree for NXT1 (if available)
    TreeFam Gene Tree for NXT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NXT1 gene
    NXT22  
    1 SIMAP similar gene for NXT1 using alignment to 1 protein entry:     NXT1_HUMAN:
    NXT2

    NXT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NXT1
    PGOHUM00000248372


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NXT1 (see all 152)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018819121,2
    C--23329406(+) TCAATA/TGATCA 1 -- us2k10--------
    rs746504131,2
    C--23329411(+) TGATCA/GTGACC 1 -- us2k10--------
    rs2010881291,2
    C--23329423(+) TCTCAC/TGTGGA 1 -- us2k10--------
    rs1997112531,2
    C--23329425(+) TCACGC/TGGACC 1 -- us2k10--------
    rs1411956921,2
    C--23329437(+) CCTTAA/GAGTTG 1 -- us2k10--------
    rs749873891,2
    C--23329553(+) TTGGTG/TTCTGA 1 -- us2k10--------
    rs1924141111,2
    --23329587(+) TGCTAC/TAAATA 1 -- us2k10--------
    rs790776071,2
    C,F--23329628(+) GAGAGC/GAGGGA 1 -- us2k11Minor allele frequency- G:0.11EA 120
    rs1858341331,2
    --23329641(+) GAGTGC/TTGAGG 1 -- us2k10--------
    rs1507530411,2
    --23329682(+) CATGAC/TTTGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NXT1 (23331373 - 23335414 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NXT1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NXT1
    DNA2.0 Custom Variant and Variant Library Synthesis for NXT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605811    OMIM disorders: --

    5 diseases for NXT1:    About MalaCards
    conjunctivitis    influenza    mental retardation    malaria
    obesity


    NXT1 for disorders           About GeneDecksing


    Export disorders for NXT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NXT1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with NXT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. (PubMed id 11259602)1, 2, 3, 9 Guzik B.W.... Hammarskjold M.L. (Mol. Cell. Biol. 2001)
    2. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. (PubMed id 10567585)1, 2, 3, 9 Black B.E.... Paschal B.M. (Mol. Cell. Biol. 1999)
    3. RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro. (PubMed id 10848583)1, 2, 9 Ossareh-Nazari B....Dargemont C. (Mol. Cell. Biol. 2000)
    4. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. (PubMed id 11583626)1, 2, 9 Fribourg S.... Conti E. (Mol. Cell 2001)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PubMed id 11073998)1, 9 Herold A.... Izaurralde E. (Mol. Cell. Biol. 2000)
    8. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. (PubMed id 10228171)1, 9 Katahira J....Hurt E. (EMBO J. 1999)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Entrez Gene: 29107 HGNC: 15913 AceView: NXT1 Ensembl:ENSG00000132661 euGenes: HUgn29107
    ECgene: NXT1 Kegg: 29107 H-InvDB: NXT1

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NXT1 Pharmacogenomics, SNPs, Pathways

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