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Aliases for NXT1 Gene

Aliases for NXT1 Gene

  • Nuclear Transport Factor 2-Like Export Factor 1 2 3
  • NTF2-Like Export Factor 1 2 3
  • NTX2-Like Export Factor1 2 3
  • Protein P15 3 4
  • MTr2 3 6
  • NTF2-Related Export Protein 1 3
  • NUTF-Like Export Factor 1 3
  • P15 3

External Ids for NXT1 Gene

Previous GeneCards Identifiers for NXT1 Gene

  • GC20P023319
  • GC20P023326
  • GC20P023279

Summaries for NXT1 Gene

Entrez Gene Summary for NXT1 Gene

  • The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NXT1 Gene

NXT1 (Nuclear Transport Factor 2-Like Export Factor 1) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include Ran GTPase binding. An important paralog of this gene is NXT2.

UniProtKB/Swiss-Prot for NXT1 Gene

  • Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.

Gene Wiki entry for NXT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXT1 Gene

Genomics for NXT1 Gene

Regulatory Elements for NXT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NXT1 Gene

Start:
23,350,736 bp from pter
End:
23,354,777 bp from pter
Size:
4,042 bases
Orientation:
Plus strand

Genomic View for NXT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXT1 Gene

Proteins for NXT1 Gene

  • Protein details for NXT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKK6-NXT1_HUMAN
    Recommended name:
    NTF2-related export protein 1
    Protein Accession:
    Q9UKK6
    Secondary Accessions:

    Protein attributes for NXT1 Gene

    Size:
    140 amino acids
    Molecular mass:
    15847 Da
    Quaternary structure:
    • Heterodimer with NXF1. Interacts (via NTF2 domain) with NXF1. Stablizes the NTF2 domain of NXF1 by heterodimerization. The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export. Preferentially binds Ran-GTP. Associates with NXF2, NXF3 and NXF5. Does not bind nucleoporins (NPC) directly, its association to NPC is mediated by NXF1.

    Three dimensional structures from OCA and Proteopedia for NXT1 Gene

neXtProt entry for NXT1 Gene

Proteomics data for NXT1 Gene at MOPED

Post-translational modifications for NXT1 Gene

  • Ubiquitination at Lys7 and Lys30
  • Modification sites at PhosphoSitePlus

Other Protein References for NXT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXT1 Gene

Domains for NXT1 Gene

Protein Domains for NXT1 Gene

Suggested Antigen Peptide Sequences for NXT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKK6

UniProtKB/Swiss-Prot:

NXT1_HUMAN :
  • Q9UKK6
Domain:
  • Contains 1 NTF2 domain.
genes like me logo Genes that share domains with NXT1: view

No data available for Gene Families for NXT1 Gene

Function for NXT1 Gene

Molecular function for NXT1 Gene

UniProtKB/Swiss-Prot Function: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.

Gene Ontology (GO) - Molecular Function for NXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11566096
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with NXT1: view

Phenotypes for NXT1 Gene

GenomeRNAi human phenotypes for NXT1:
genes like me logo Genes that share phenotypes with NXT1: view

Animal Model Products

CRISPR Products

miRNA for NXT1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NXT1 Gene

Localization for NXT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXT1 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXT1 Gene COMPARTMENTS Subcellular localization image for NXT1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005643 nuclear pore IEA --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with NXT1: view

Pathways for NXT1 Gene

genes like me logo Genes that share pathways with NXT1: view

Pathways by source for NXT1 Gene

Gene Ontology (GO) - Biological Process for NXT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006405 RNA export from nucleus IEA --
GO:0006611 protein export from nucleus IEA --
GO:0006810 transport --
genes like me logo Genes that share ontologies with NXT1: view

Compounds for NXT1 Gene

(1) HMDB Compounds for NXT1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for NXT1 Gene

Compound -log(P) Hits PubMed IDs
leptomycin b 81.1 2
genes like me logo Genes that share compounds with NXT1: view

Transcripts for NXT1 Gene

mRNA/cDNA for NXT1 Gene

Unigene Clusters for NXT1 Gene

NTF2-like export factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXT1 Gene

No ASD Table

Relevant External Links for NXT1 Gene

GeneLoc Exon Structure for
NXT1
ECgene alternative splicing isoforms for
NXT1

Expression for NXT1 Gene

mRNA expression in normal human tissues for NXT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NXT1 Gene

SOURCE GeneReport for Unigene cluster for NXT1 Gene Hs.516933

genes like me logo Genes that share expressions with NXT1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NXT1 Gene

Orthologs for NXT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXT1 35
  • 99.29 (n)
  • 100 (a)
NXT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NXT1 35
  • 89.21 (n)
  • 97.12 (a)
NXT1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXT1 35
  • 91.19 (n)
  • 98.57 (a)
mouse
(Mus musculus)
Mammalia Nxt1 35
  • 91.43 (n)
  • 98.57 (a)
Nxt1 16
Nxt1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxt1 35
  • 91.43 (n)
  • 97.86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1856 35
zebrafish
(Danio rerio)
Actinopterygii nxt2 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008234 35
  • 54.26 (n)
  • 46.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nxt1 35
  • 52.2 (n)
  • 42.64 (a)
Nxt1 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nxt-1 36
  • 29 (a)
OneToMany
Species with no ortholog for NXT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXT1 Gene

ENSEMBL:
Gene Tree for NXT1 (if available)
TreeFam:
Gene Tree for NXT1 (if available)

Paralogs for NXT1 Gene

Paralogs for NXT1 Gene

Selected SIMAP similar genes for NXT1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NXT1 Gene

genes like me logo Genes that share paralogs with NXT1: view

Variants for NXT1 Gene

Sequence variations from dbSNP and Humsavar for NXT1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2683 -- 23,354,662(-) ACTAT(A/G)ACAAA utr-variant-3-prime
rs761722 -- 23,350,205(-) ACTTA(C/G)AGGCG upstream-variant-2KB
rs761723 -- 23,350,083(-) GGCTC(C/T)CCACT upstream-variant-2KB
rs1046125 -- 23,354,608(+) GAACT(C/T)TTTTT utr-variant-3-prime
rs1046128 -- 23,354,615(+) TTTTT(G/T)TTGCT utr-variant-3-prime

Relevant External Links for NXT1 Gene

HapMap Linkage Disequilibrium report
NXT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NXT1 Gene

Disorders for NXT1 Gene

No disorders were found for NXT1 Gene.

No data available for UniProtKB/Swiss-Prot for NXT1 Gene

Publications for NXT1 Gene

  1. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. (PMID: 11259602) Guzik B.W. … Hammarskjold M.L. (Mol. Cell. Biol. 2001) 2 3 4 23
  2. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. (PMID: 10567585) Black B.E. … Paschal B.M. (Mol. Cell. Biol. 1999) 2 3 4 23
  3. RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro. (PMID: 10848583) Ossareh-Nazari B. … Dargemont C. (Mol. Cell. Biol. 2000) 3 4 23
  4. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. (PMID: 11583626) Fribourg S. … Conti E. (Mol. Cell 2001) 3 4 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NXT1 Gene

Sources for NXT1 Gene

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