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Aliases for NXPH4 Gene

Aliases for NXPH4 Gene

  • Neurexophilin 4 2 3 5
  • NPH4 3 4

External Ids for NXPH4 Gene

Previous GeneCards Identifiers for NXPH4 Gene

  • GC00U990505
  • GC12U900046
  • GC12P057327
  • GC12P055896
  • GC12P057610
  • GC12P054657

Summaries for NXPH4 Gene

GeneCards Summary for NXPH4 Gene

NXPH4 (Neurexophilin 4) is a Protein Coding gene. An important paralog of this gene is NXPH3.

UniProtKB/Swiss-Prot for NXPH4 Gene

  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH4 Gene

Genomics for NXPH4 Gene

Regulatory Elements for NXPH4 Gene

Enhancers for NXPH4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NXPH4 on UCSC Golden Path with GeneCards custom track

Promoters for NXPH4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NXPH4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXPH4 Gene

Chromosome:
12
Start:
57,216,795 bp from pter
End:
57,226,449 bp from pter
Size:
9,655 bases
Orientation:
Plus strand

Genomic View for NXPH4 Gene

Genes around NXPH4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH4 Gene

Proteins for NXPH4 Gene

  • Protein details for NXPH4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95158-NXPH4_HUMAN
    Recommended name:
    Neurexophilin-4
    Protein Accession:
    O95158
    Secondary Accessions:
    • A8K4I4
    • Q7Z6L3
    • Q8N462

    Protein attributes for NXPH4 Gene

    Size:
    308 amino acids
    Molecular mass:
    33065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH4 Gene

Proteomics data for NXPH4 Gene at MOPED

Post-translational modifications for NXPH4 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn 72, Asn 133, Asn 143, and Asn 149
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH4 Gene

Domains & Families for NXPH4 Gene

Protein Domains for NXPH4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NXPH4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95158

UniProtKB/Swiss-Prot:

NXPH4_HUMAN :
  • Belongs to the neurexophilin family.
Family:
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH4: view

No data available for Gene Families for NXPH4 Gene

Function for NXPH4 Gene

Molecular function for NXPH4 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
genes like me logo Genes that share phenotypes with NXPH4: view

Animal Models for NXPH4 Gene

MGI Knock Outs for NXPH4:

Animal Model Products

  • Taconic Biosciences Mouse Models for NXPH4

miRNA for NXPH4 Gene

miRTarBase miRNAs that target NXPH4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXPH4 Gene

Localization for NXPH4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXPH4 Gene COMPARTMENTS Subcellular localization image for NXPH4 gene
Compartment Confidence
extracellular 4
mitochondrion 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NXPH4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH4: view

Pathways & Interactions for NXPH4 Gene

SuperPathways for NXPH4 Gene

No Data Available

Interacting Proteins for NXPH4 Gene

Selected Interacting proteins: O95158-NXPH4_HUMAN for NXPH4 Gene via I2D

Symbol External ID(s) Details
TECPR1

Gene Ontology (GO) - Biological Process for NXPH4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NXPH4 Gene

Drugs & Compounds for NXPH4 Gene

No Compound Related Data Available

Transcripts for NXPH4 Gene

mRNA/cDNA for NXPH4 Gene

Unigene Clusters for NXPH4 Gene

Neurexophilin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for NXPH4 Gene

GeneLoc Exon Structure for
NXPH4
ECgene alternative splicing isoforms for
NXPH4

Expression for NXPH4 Gene

mRNA expression in normal human tissues for NXPH4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPH4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x8.3), Skin - Sun Exposed (Lower leg) (x6.8), Brain - Cerebellum (x6.3), and Brain - Cerebellar Hemisphere (x6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NXPH4 Gene



SOURCE GeneReport for Unigene cluster for NXPH4 Gene Hs.745023

mRNA Expression by UniProt/SwissProt for NXPH4 Gene

O95158-NXPH4_HUMAN
Tissue specificity: Expressed in brain, spleen, and testis.
genes like me logo Genes that share expression patterns with NXPH4: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for NXPH4 Gene

Orthologs for NXPH4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NXPH4 35
  • 87.85 (n)
  • 90.28 (a)
NXPH4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXPH4 35
  • 86.16 (n)
  • 87.89 (a)
NXPH4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nxph4 35
  • 86.84 (n)
  • 88.82 (a)
Nxph4 16
Nxph4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NXPH4 35
  • 99.78 (n)
  • 99.68 (a)
NXPH4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxph4 35
  • 86.4 (n)
  • 90.13 (a)
oppossum
(Monodelphis domestica)
Mammalia NXPH4 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NXPH4 36
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii NXPH4 (1 of 2) 36
  • 31 (a)
OneToMany
NXPH4 (2 of 2) 36
  • 54 (a)
OneToMany
Species with no ortholog for NXPH4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH4 Gene

ENSEMBL:
Gene Tree for NXPH4 (if available)
TreeFam:
Gene Tree for NXPH4 (if available)

Paralogs for NXPH4 Gene

Paralogs for NXPH4 Gene

(3) SIMAP similar genes for NXPH4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NXPH4: view

Variants for NXPH4 Gene

Sequence variations from dbSNP and Humsavar for NXPH4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7134826 -- 57,221,175(+) GTCCT(G/T)TCCAC intron-variant
rs7298340 -- 57,216,251(+) GGCGG(A/C)GGGCG upstream-variant-2KB
rs7311958 -- 57,219,642(+) TGGGC(C/T)ACTTA intron-variant
rs17853694 -- 57,225,707(+) GTGCC(A/C)AGACT reference, missense
rs17853695 -- 57,224,986(+) GGTCT(A/T)CGGAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NXPH4 Gene

Variant ID Type Subtype PubMed ID
dgv96n21 CNV Loss 19592680
nsv519293 CNV Loss 19592680
nsv899116 CNV Loss 21882294

Variation tolerance for NXPH4 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NXPH4 Gene

Disorders for NXPH4 Gene

Relevant External Links for NXPH4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXPH4

No disorders were found for NXPH4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPH4 Gene

Publications for NXPH4 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M. … Suedhof T.C. (J. Neurosci. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for NXPH4 Gene

Sources for NXPH4 Gene

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