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Aliases for NXPH3 Gene

Aliases for NXPH3 Gene

  • Neurexophilin 3 2 3 5
  • NPH3 3 4
  • KIAA1159 4

External Ids for NXPH3 Gene

Previous GeneCards Identifiers for NXPH3 Gene

  • GC17P047364
  • GC17P050133
  • GC17P047995
  • GC17P048127
  • GC17P045008
  • GC17P047653
  • GC17P043018

Summaries for NXPH3 Gene

GeneCards Summary for NXPH3 Gene

NXPH3 (Neurexophilin 3) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is NXPH4.

UniProtKB/Swiss-Prot for NXPH3 Gene

  • May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Gene Wiki entry for NXPH3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH3 Gene

Genomics for NXPH3 Gene

Regulatory Elements for NXPH3 Gene

Enhancers for NXPH3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NXPH3 on UCSC Golden Path with GeneCards custom track

Promoters for NXPH3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NXPH3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXPH3 Gene

49,575,858 bp from pter
49,583,827 bp from pter
7,970 bases
Plus strand

Genomic View for NXPH3 Gene

Genes around NXPH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH3 Gene

Proteins for NXPH3 Gene

  • Protein details for NXPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8NDC3
    • Q8TBF6
    • Q9ULR1

    Protein attributes for NXPH3 Gene

    252 amino acids
    Molecular mass:
    28127 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH3 Gene

Proteomics data for NXPH3 Gene at MOPED

Post-translational modifications for NXPH3 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn 62, Asn 127, Asn 137, and Asn 143
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NXPH3 (Neurexophilin-3)

No data available for DME Specific Peptides for NXPH3 Gene

Domains & Families for NXPH3 Gene

Protein Domains for NXPH3 Gene


Suggested Antigen Peptide Sequences for NXPH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neurexophilin family.
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH3: view

No data available for Gene Families for NXPH3 Gene

Function for NXPH3 Gene

Molecular function for NXPH3 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Gene Ontology (GO) - Molecular Function for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with NXPH3: view
genes like me logo Genes that share phenotypes with NXPH3: view

Animal Models for NXPH3 Gene

MGI Knock Outs for NXPH3:

Animal Model Products

  • Taconic Biosciences Mouse Models for NXPH3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXPH3 Gene

Localization for NXPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH3 Gene


Subcellular locations from

Jensen Localization Image for NXPH3 Gene COMPARTMENTS Subcellular localization image for NXPH3 gene
Compartment Confidence
extracellular 4
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NXPH3 Gene

Pathways & Interactions for NXPH3 Gene

SuperPathways for NXPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NXPH3 Gene


No data available for Pathways by source and SIGNOR curated interactions for NXPH3 Gene

Drugs & Compounds for NXPH3 Gene

No Compound Related Data Available

Transcripts for NXPH3 Gene

mRNA/cDNA for NXPH3 Gene

Unigene Clusters for NXPH3 Gene

Neurexophilin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH3 Gene

No ASD Table

Relevant External Links for NXPH3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXPH3 Gene

mRNA expression in normal human tissues for NXPH3 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH3 Gene

This gene is overexpressed in Artery - Aorta (x7.9), Artery - Tibial (x4.8), Brain - Cerebellar Hemisphere (x4.7), and Brain - Cerebellum (x4.5).

SOURCE GeneReport for Unigene cluster for NXPH3 Gene Hs.55069

mRNA Expression by UniProt/SwissProt for NXPH3 Gene

Tissue specificity: Highest level in brain.
genes like me logo Genes that share expression patterns with NXPH3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NXPH3 Gene

Orthologs for NXPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXPH3 35
  • 91.53 (n)
  • 95.24 (a)
NXPH3 36
  • 95 (a)
(Canis familiaris)
Mammalia NXPH3 35
  • 94.05 (n)
  • 97.22 (a)
NXPH3 36
  • 97 (a)
(Mus musculus)
Mammalia Nxph3 35
  • 89.55 (n)
  • 96.43 (a)
Nxph3 16
Nxph3 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Nxph3 35
  • 89.95 (n)
  • 96.03 (a)
(Monodelphis domestica)
Mammalia NXPH3 36
  • 87 (a)
(Gallus gallus)
Aves NXPH3 35
  • 69.51 (n)
  • 63.41 (a)
(Anolis carolinensis)
Reptilia NXPH3 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph3 35
  • 60.71 (n)
  • 57.94 (a)
(Danio rerio)
Actinopterygii nxph2b 36
  • 45 (a)
Species with no ortholog for NXPH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH3 Gene

Gene Tree for NXPH3 (if available)
Gene Tree for NXPH3 (if available)

Paralogs for NXPH3 Gene

Paralogs for NXPH3 Gene

(3) SIMAP similar genes for NXPH3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NXPH3: view

Variants for NXPH3 Gene

Sequence variations from dbSNP and Humsavar for NXPH3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2537729 -- 49,576,913(+) CTCGG(A/C)GACCC intron-variant
rs2537730 -- 49,580,462(+) CAGGG(A/C)TCCAA utr-variant-3-prime
rs2676791 -- 49,576,442(+) TGGAC(A/T)GATAG intron-variant
rs2676792 -- 49,577,731(+) GCCCC(A/G)GTGTC intron-variant
rs2676793 -- 49,579,826(+) GCCCT(C/G)AGCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NXPH3 Gene

Variant ID Type Subtype PubMed ID
nsv908585 CNV Loss 21882294
nsv2078 CNV Loss 18451855

Variation tolerance for NXPH3 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPH3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPH3 Gene

Disorders for NXPH3 Gene

Relevant External Links for NXPH3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NXPH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPH3 Gene

Publications for NXPH3 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M. … Suedhof T.C. (J. Neurosci. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for NXPH3 Gene

Sources for NXPH3 Gene