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NXPH3 Gene

protein-coding   GIFtS: 50
GCID: GC17P047653

Neurexophilin 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neurexophilin 31 2
NPH32 3
neurexophilin-32
KIAA11593

External Ids:    HGNC: 80771   Entrez Gene: 112482   Ensembl: ENSG000001825757   OMIM: 6046365   UniProtKB: O951573   

Export aliases for NXPH3 gene to outside databases

Previous GC identifers: GC17P047364 GC17P050133 GC17P047995 GC17P048127 GC17P045008 GC17P043018


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NXPH3 Gene:
NXPH3 (neurexophilin 3) is a protein-coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is NXPH4.

UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157
Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity)

Gene Wiki entry for NXPH3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NXPH3 gene promoter:
         MAZR   GCNF   GATA-2   POU2F1   CP2   HOXA5   POU2F1a   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXPH3 promoter sequence
   Search Chromatin IP Primers for NXPH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NXPH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q

NXPH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXPH3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P047653:  view genomic region     (about GC identifiers)

Start:
47,653,220 bp from pter      End:
47,661,189 bp from pter
Size:
7,970 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157 (See protein sequence)
Recommended Name: Neurexophilin-3 precursor  
Size: 252 amino acids; 28127 Da
Secondary accessions: Q8NDC3 Q8TBF6 Q9ULR1

Explore the universe of human proteins at neXtProt for NXPH3: NX_O95157

Explore proteomics data for NXPH3 at MOPED

Post-translational modifications: 

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved
    domain in neuron-like cells (By similarity)1
  • Glycosylation2 at Asn62, Asn127, Asn137, Asn143
  • Modification sites at PhosphoSitePlus

  • See NXPH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009156.2  
    ENSEMBL proteins: 
     ENSP00000329295   ENSP00000421168  

    NXPH3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NXPH3

     
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    antibodies-online proteins for NXPH3 (4 products) 

     
    antibodies-online peptides for NXPH3

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    antibodies-online antibodies for NXPH3 (34 products) 

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    Cloud-Clone Corp. CLIAs for NXPH3
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    antibodies-online kits for NXPH3 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010450 Neurexophilin
     IPR026845 NXPH/NXPE

    Graphical View of Domain Structure for InterPro Entry O95157

    ProtoNet protein and cluster: O95157

    1 Blocks protein domain: IPB010450 Neurexophilin

    UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157
    Similarity: Belongs to the neurexophilin family


    Find genes that share domains with NXPH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXPH3_HUMAN, O95157
    Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005102receptor binding IEA--
         
    Find genes that share ontologies with NXPH3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NXPH3:
     Decreased number of cells in m  Increased cell number in G1, a  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nxph3):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  normal 
     reproductive system 

    Find genes that share phenotypes with NXPH3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NXPH3: Nxph3tm1.1Mami Nxph3tm1Lex

       genOway: Develop your customized and physiologically relevant rodent model for NXPH3

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NXPH3 (see all 47):
    hsa-miR-549 hsa-miR-328 hsa-miR-765 hsa-miR-516a-5p hsa-miR-764 hsa-miR-766 hsa-miR-4267 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidNXPH3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NXPH3_HUMAN, O95157: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with NXPH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NXPH3
    Interactions:

        Search GeneGlobe Interaction Network for NXPH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for NXPH3 (O951571, 2, 3 ENSP000003292954) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-1752913,EBI-375543 MINT-8110587 I2D: score=3 STRING: ENSP00000361423
    CRKP461081, 3, ENSP000003005744EBI-1752913,EBI-886 I2D: score=2 STRING: ENSP00000300574
    TAB1Q157502, 3MINT-8260218 I2D: score=2 
    SRCP129311, 2, 3, ENSP000003509414EBI-1752913,EBI-621482 MINT-8113167 I2D: score=3 STRING: ENSP00000350941
    NCK1P163331, 3, ENSP000002889864EBI-1752913,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007218neuropeptide signaling pathway NAS9570794

    Find genes that share ontologies with NXPH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NXPH3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NXPH3 gene: 
    NM_007225.2  

    Unigene Cluster for NXPH3:

    Neurexophilin 3
    Hs.55069  [show with all ESTs]
    Unigene Representative Sequence: NM_007225
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328741(uc002ipa.3) ENST00000513748 ENST00000570453
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NXPH3 (see all 47):
    hsa-miR-549 hsa-miR-328 hsa-miR-765 hsa-miR-516a-5p hsa-miR-764 hsa-miR-766 hsa-miR-4267 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidNXPH3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NXPH3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXPH3
      QuantiTect SYBR Green Assays in human, mouse, rat NXPH3
      QuantiFast Probe-based Assays in human, mouse, rat NXPH3

    Additional mRNA sequence: 

    AB032985.1 AF043468.1 AK308928.1 AL834282.1 AY358526.1 BC022541.1 

    1 DOTS entry:

    DT.202259 

    Selected AceView cDNA sequences (see all 48):

    BM719416 CR600551 AY358526 BM930998 AL834282 BM810584 AL535326 AB032985 
    BM560110 AA338636 BX283684 BF969281 BF221827 AI369443 BM684247 BX452179 
    AW449723 H38679 BX423307 AI937333 BI916355 BF507962 AA325618 BX461235 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NXPH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGGATCT
    NXPH3 Expression
    About this image

    NXPH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NXPH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.55069

    UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157
    Tissue specificity: Highest level in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NXPH3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxph31 , 5 neurexophilin 31, 5 89.55(n)1
    96.43(a)1
      11 (59.01 cM)5
    1040791  NM_130858.31  NP_570928.11 
     955098455 
    chicken
    (Gallus gallus)
    Aves NXPH31 neurexophilin 3 69.51(n)
    63.41(a)
      429523  XM_004948548.1  XP_004948605.1 
    lizard
    (Anolis carolinensis)
    Reptilia NXPH36
    neurexophilin 3
    57(a)
    1 ↔ 1
    6(76651415-76676192)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nxph31 neurexophilin 3 60.71(n)
    57.94(a)
      100125096  NM_001103007.1  NP_001096477.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nxph2b6
    neurexophilin 2b
    45(a)
    many ↔ many
    11(34683134-34684155) ENSDARG00000079188


    ENSEMBL Gene Tree for NXPH3 (if available)
    TreeFam Gene Tree for NXPH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NXPH3 gene
    NXPH42  NXPH12  NXPH22  
    3 SIMAP similar genes for NXPH3 using alignment to 3 protein entries:     NXPH3_HUMAN (see all proteins):
    NXPH1    Nbla00697    NXPH2

    Find genes that share paralogs with NXPH3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NXPH3 (see all 163)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420931721,2
    Cuntested147656171(+) ACAGCC/TCCCCA 2 P S mis11Minor allele frequency- T:0.00NA 4106
    rs2005354761,2
    --47653535(+) GGGACA/CCCGAA 1 -- ut510--------
    rs1453586701,2
    C--47653545(+) AAAGAA/GAAGGG 1 -- ut510--------
    rs751057941,2
    C--47653607(+) CTTCGC/TGTTCC 2 A V mis10--------
    rs26767911,2
    C,F,A,H--47653804(+) TGGACT/AGATAG 1 -- int19Minor allele frequency- A:0.29NS EA WA NA 774
    rs129522981,2
    C--47654052(+) CCCCAG/TAGCAC 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1450770181,2
    --47654112(+) TCCCTC/GCCGCT 1 -- int10--------
    rs1920283581,2
    --47654185(+) GGACTC/TGGGCA 1 -- int10--------
    rs25377291,2
    C,A--47654275(+) CTCGGA/CGACCC 1 -- int16Minor allele frequency- C:0.31NA WA EA 364
    rs787380141,2
    C,F--47654400(+) CTGCCC/TCTTTA 1 -- int11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for NXPH3 (47653220 - 47661189 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NXPH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2078CNV Loss18451855
    nsv908585CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NXPH3
    DNA2.0 Custom Variant and Variant Library Synthesis for NXPH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604636    OMIM disorders: --


    Find genes that share disorders with NXPH3           About GenesLikeMe


    Export disorders for NXPH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NXPH3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with NXPH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PubMed id 9570794)1, 2, 3 Missler M. and Suedhof T.C. (J. Neurosci. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    6. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    7. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    8. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11248 HGNC: 8077 AceView: NXPH3 Ensembl:ENSG00000182575 euGenes: HUgn11248
    ECgene: NXPH3 H-InvDB: NXPH3

    (According to HUGE)
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    HUGE: KIAA1159

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NXPH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NXPH3 gene:
    Search GeneIP for patents involving NXPH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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