NXPH3 Gene
protein-coding GIFtS: 49
GCID: GC17P047653
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|
neurexophilin 3
| |
Aliases for NXPH3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Neurexophilin 31 2 | | NPH31 2 3 | | Neurexophilin-31 | | KIAA11593 |
Export aliases for NXPH3 gene to outside databasesPrevious GC identifers: GC17P047364 GC17P050133 GC17P047995 GC17P048127 GC17P045008 GC17P043018 |
Summaries for NXPH3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) Gene Wiki entry for NXPH3
|
Genomic Views for NXPH3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NXPH3 gene promoter: MAZR GCNF GATA-2 POU2F1 CP2 HOXA5 POU2F1a GCNF-1 GCNF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for NXPH3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPH3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17qNXPH3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P047653: view genomic region
(about GC identifiers)
Start:
|
47,653,220 bp from pter |
End:
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47,661,189 bp from pter |
Size:
|
7,970 bases |
Orientation:
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plus strand |
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Proteins for NXPH3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157 (See
protein sequence)Recommended Name: Neurexophilin-3 precursor Size: 252 amino acids; 28127 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q8NDC3 Q8TBF6 Q9ULR1Explore the universe of human proteins at neXtProt for NXPH3: NX_O95157
Post-translational modifications:
May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domainin neuron-like cells (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95157 NXPH3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009156.2 ENSEMBL proteins: ENSP00000329295 ENSP00000421168 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- |
NXPH3 for ontologies About GeneDecksing
NXPH3 Antibody Products: Assay Products for NXPH3: |
Protein
Domains / Families for NXPH3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NXPH3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95157ProtoNet protein and cluster: O95157 1 Blocks protein family: IPB010450 Neurexophilin
UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157Similarity: Belongs to the neurexophilin family |
Function for NXPH3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NXPH3 (NM_007225) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPH3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH3  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005102 | receptor binding |
IEA | -- |
NXPH3 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for NXPH3: Animal Models: Mouse knock-out Nxph3tm1.1Mami for NXPH3 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Nxph3):
NXPH3 for phenotypes About GeneDecksing
|
Pathways & Interactions for NXPH3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXPH3
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
 5/8 Interacting proteins for NXPH3 (O951571, 2, 3 ENSP000003292954) via UniProtKB, MINT, STRING, and/or I2D (see all 8)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ABL1 | P005191, 2, 3, ENSP000003614234 | EBI-1752913,EBI-375543 MINT-8110587 I2D:
score=3 STRING: ENSP00000361423 | | CRK | P461081, 3, ENSP000003005744 | EBI-1752913,EBI-886 I2D:
score=2 STRING: ENSP00000300574 | | TAB1 | Q157502, 3 | MINT-8260218 I2D:
score=2 | | SRC | P129311, 2, 3, ENSP000003509414 | EBI-1752913,EBI-621482 MINT-8113167 I2D:
score=3 STRING: ENSP00000350941 | | NCK1 | P163331, 3, ENSP000002889864 | EBI-1752913,EBI-389883 I2D:
score=2 STRING: ENSP00000288986 | About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007218 | neuropeptide signaling pathway |
NAS | 9570794 |
NXPH3 for ontologies About GeneDecksing
|
Drugs & Compounds for NXPH3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for NXPH3 Search CenterWatch for drugs/clinical trials and news about NXPH3 
|
Transcripts for NXPH3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for NXPH3 gene: NM_007225.2 Unigene Cluster for NXPH3: Neurexophilin 3 Hs.55069 [show with all ESTs]Unigene Representative Sequence: NM_0072253 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000328741(uc002ipa.3) ENST00000513748 ENST00000570453
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NXPH3 (NM_007225) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPH3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH3  |
Additional cDNA sequence: AB032985.1 AF043468.1 AK308928.1 AL834282.1 AY358526.1 BC022541.1 1 DOTS entry: DT.202259 24/48 AceView cDNA sequences (see all 48): AY358526 AL535326 AI369443 BM684247 CR600551 BM719416 BF221827 BM560110 AB032985 BF969281 BX283684 AA338636 BM810584 BM930998 AL834282 BX423307 AI937333 H38679 AI367153 AW449723 BX100608 NM_007225 BC022541 AF043468 GeneLoc Exon Structure
|
Expression for NXPH3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NXPH3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGCTGGATCT
About this image See NXPH3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NXPH3
SOURCE GeneReport for Unigene cluster: Hs.55069 UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157Tissue specificity: Highest level in brain SABiosciences Custom PCR Arrays for NXPH3
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXPH3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NXPH3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPH3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPH3 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH3 |
Orthologs for NXPH3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NXPH3 gene from 3/8 species (see all 8) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
NXPH31 |
neurexophilin 3 |
69.15(n) 63.6(a) |
  |
429523 XM_427080.2 XP_427080.1 |
lizard (Anolis carolinensis) |
Reptilia |
NXPH36 |
-- |
66(a) |
1 ↔ 1 |
6(76670860-76671324) |
zebrafish (Danio rerio) |
Actinopterygii |
BX649458.16 |
-- |
47(a) |
1 ↔ 1 |
3(20294524-20354236) |
ENSEMBL Gene Tree for NXPH3 (if available) TreeFam Gene Tree for NXPH3 (if available)  |
Paralogs for NXPH3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for NXPH3 gene
- NXPH42 NXPH12 NXPH22
3 SIMAP similar genes for NXPH3 using alignment to 3 protein entries: NXPH3_HUMAN (see all proteins):NXPH1 Nbla00697 NXPH2
NXPH3 for paralogs About GeneDecksing
|
Genomic Variants for NXPH3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for NXPH3 (47653220 - 47661189 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NXPH3: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPH3 |
|
Disorders
/ Diseases for NXPH3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NXPH3 for disorders About MalaCards
NXPH3 for disorders About GeneDecksing
OMIM gene information: 604636
OMIM disorders: --
Export disorders for NXPH3 gene to outside databases
|
Publications for NXPH3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NXPH3 gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with NXPH3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PubMed id 9570794)1, 2, 3 Missler M. and Suedhof T.C. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NXPH3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NXPH3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NXPH3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing NXPH3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for NXPH3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NXPH3 gene: Search GeneIP for patents involving NXPH3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for NXPH3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for NXPH3 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXPH3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXPH3 | | OriGene Protein Over-expression Lysate for NXPH3 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for NXPH3 | | OriGene 3'-UTR Clone for NXPH3 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH3 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for NXPH3 | | OriGene Custom Protein Services for NXPH3 | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NXPH3 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPH3 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPH3 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXPH3 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPH3 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPH3 |
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| | | Search Tocris compounds for NXPH3 |
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 | | NXPH3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH3 |
|  |  |  | | | Search ThermoFisher Antibodies for NXPH3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH3 |
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