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Aliases for NXPH3 Gene

Aliases for NXPH3 Gene

  • Neurexophilin 3 2 3
  • NPH3 3 4
  • Neurexophilin-3 3
  • KIAA1159 4

External Ids for NXPH3 Gene

Summaries for NXPH3 Gene

GeneCards Summary for NXPH3 Gene

NXPH3 (Neurexophilin 3) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is NXPH4.

UniProtKB/Swiss-Prot for NXPH3 Gene

  • May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Gene Wiki entry for NXPH3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH3 Gene

Genomics for NXPH3 Gene

Genomic Location for NXPH3 Gene

Start:
49,575,858 bp from pter
End:
49,583,827 bp from pter
Size:
7,970 bases
Orientation:
Plus strand

Genomic View for NXPH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH3 Gene

Regulatory Elements for NXPH3 Gene

Proteins for NXPH3 Gene

  • Protein details for NXPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95157-NXPH3_HUMAN
    Recommended name:
    Neurexophilin-3
    Protein Accession:
    O95157
    Secondary Accessions:
    • Q8NDC3
    • Q8TBF6
    • Q9ULR1

    Protein attributes for NXPH3 Gene

    Size:
    252 amino acids
    Molecular mass:
    28127 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH3 Gene

Proteomics data for NXPH3 Gene at MOPED

Post-translational modifications for NXPH3 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn62, Asn127, Asn137, and Asn143

Other Protein References for NXPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH3 Gene

Domains for NXPH3 Gene

Protein Domains for NXPH3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NXPH3_HUMAN
Family:
  • Belongs to the neurexophilin family.:
    • O95157
genes like me logo Genes that share domains with NXPH3: view

No data available for Gene Families for NXPH3 Gene

Function for NXPH3 Gene

Molecular function for NXPH3 Gene

UniProtKB/Swiss-Prot Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Gene Ontology (GO) - Molecular Function for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with NXPH3: view
genes like me logo Genes that share phenotypes with NXPH3: view

Animal Models for NXPH3 Gene

MGI Knock Outs for NXPH3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NXPH3 Gene

Localization for NXPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXPH3 Gene COMPARTMENTS Subcellular localization image for NXPH3 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH3: view

Pathways for NXPH3 Gene

SuperPathways for NXPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 9570794
genes like me logo Genes that share ontologies with NXPH3: view

No data available for Pathways by source for NXPH3 Gene

Transcripts for NXPH3 Gene

mRNA/cDNA for NXPH3 Gene

Unigene Clusters for NXPH3 Gene

Neurexophilin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH3 Gene

No ASD Table

Relevant External Links for NXPH3 Gene

GeneLoc Exon Structure for
NXPH3
ECgene alternative splicing isoforms for
NXPH3

Expression for NXPH3 Gene

mRNA expression in normal human tissues for NXPH3 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH3 Gene

This gene is overexpressed in Artery - Aorta (7.9), Artery - Tibial (4.8), Brain - Cerebellar Hemisphere (4.7), and Brain - Cerebellum (4.5).

SOURCE GeneReport for Unigene cluster for NXPH3 Gene Hs.55069

mRNA Expression by UniProt/SwissProt for NXPH3 Gene

O95157-NXPH3_HUMAN
Tissue specificity: Highest level in brain
genes like me logo Genes that share expressions with NXPH3: view

Orthologs for NXPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NXPH3 36
  • 91.53 (n)
  • 95.24 (a)
NXPH3 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXPH3 36
  • 94.05 (n)
  • 97.22 (a)
NXPH3 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nxph3 36
  • 89.55 (n)
  • 96.43 (a)
Nxph3 16
Nxph3 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NXPH3 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxph3 36
  • 89.95 (n)
  • 96.03 (a)
chicken
(Gallus gallus)
Aves NXPH3 36
  • 69.51 (n)
  • 63.41 (a)
lizard
(Anolis carolinensis)
Reptilia NXPH3 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph3 36
  • 60.71 (n)
  • 57.94 (a)
zebrafish
(Danio rerio)
Actinopterygii nxph2b 37
  • 45 (a)
ManyToMany
Species with no ortholog for NXPH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH3 Gene

ENSEMBL:
Gene Tree for NXPH3 (if available)
TreeFam:
Gene Tree for NXPH3 (if available)

Paralogs for NXPH3 Gene

Paralogs for NXPH3 Gene

Selected SIMAP similar genes for NXPH3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NXPH3: view

Variants for NXPH3 Gene

Sequence variations from dbSNP and Humsavar for NXPH3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2537729 -- 49,576,913(+) CTCGG(A/C)GACCC intron-variant
rs2537730 -- 49,580,462(+) CAGGG(A/C)TCCAA utr-variant-3-prime
rs2676791 -- 49,576,442(+) TGGAC(A/T)GATAG intron-variant
rs2676792 -- 49,577,731(+) GCCCC(A/G)GTGTC intron-variant
rs2676793 -- 49,579,826(+) GCCCT(C/G)AGCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NXPH3 Gene

Variant ID Type Subtype PubMed ID
nsv908585 CNV Loss 21882294
nsv2078 CNV Loss 18451855

Relevant External Links for NXPH3 Gene

HapMap Linkage Disequilibrium report
NXPH3
Human Gene Mutation Database (HGMD)
NXPH3

Disorders for NXPH3 Gene

No disorders were found for NXPH3 Gene.

No data available for UniProtKB/Swiss-Prot for NXPH3 Gene

Publications for NXPH3 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M. … Suedhof T.C. (J. Neurosci. 1998) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4

Products for NXPH3 Gene

Sources for NXPH3 Gene

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