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Aliases for NXPH3 Gene

Aliases for NXPH3 Gene

  • Neurexophilin 3 2 3 5
  • NPH3 3 4
  • Neurexophilin-3 3
  • KIAA1159 4

External Ids for NXPH3 Gene

Previous GeneCards Identifiers for NXPH3 Gene

  • GC17P047364
  • GC17P050133
  • GC17P047995
  • GC17P048127
  • GC17P045008
  • GC17P047653
  • GC17P043018

Summaries for NXPH3 Gene

GeneCards Summary for NXPH3 Gene

NXPH3 (Neurexophilin 3) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is NXPH1.

UniProtKB/Swiss-Prot for NXPH3 Gene

  • May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Gene Wiki entry for NXPH3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH3 Gene

Genomics for NXPH3 Gene

Regulatory Elements for NXPH3 Gene


Enhancers around NXPH3 on UCSC Golden Path with GeneCards custom track

Promoters for NXPH3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095501 442 1401 ARNT ARID4B SIN3A ZNF2 ZNF121 GLIS2 CBX5 ELK1 ZNF416 ZNF143

Genomic Location for NXPH3 Gene

Chromosome:
17
Start:
49,575,858 bp from pter
End:
49,583,827 bp from pter
Size:
7,970 bases
Orientation:
Plus strand

Genomic View for NXPH3 Gene

Genes around NXPH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH3 Gene

Proteins for NXPH3 Gene

  • Protein details for NXPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95157-NXPH3_HUMAN
    Recommended name:
    Neurexophilin-3
    Protein Accession:
    O95157
    Secondary Accessions:
    • Q8NDC3
    • Q8TBF6
    • Q9ULR1

    Protein attributes for NXPH3 Gene

    Size:
    252 amino acids
    Molecular mass:
    28127 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH3 Gene

Post-translational modifications for NXPH3 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn62, Asn127, Asn137, and Asn143
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH3 Gene

Domains & Families for NXPH3 Gene

Protein Domains for NXPH3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NXPH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95157

UniProtKB/Swiss-Prot:

NXPH3_HUMAN :
  • Belongs to the neurexophilin family.
Family:
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH3: view

No data available for Gene Families for NXPH3 Gene

Function for NXPH3 Gene

Molecular function for NXPH3 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity).

Gene Ontology (GO) - Molecular Function for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 receptor binding IBA,IEA --
genes like me logo Genes that share ontologies with NXPH3: view
genes like me logo Genes that share phenotypes with NXPH3: view

Animal Models for NXPH3 Gene

MGI Knock Outs for NXPH3:

Animal Model Products

  • Taconic Biosciences Mouse Models for NXPH3

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXPH3 Gene

Localization for NXPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPH3 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH3: view

Pathways & Interactions for NXPH3 Gene

SuperPathways for NXPH3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NXPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 9570794
genes like me logo Genes that share ontologies with NXPH3: view

No data available for Pathways by source and SIGNOR curated interactions for NXPH3 Gene

Drugs & Compounds for NXPH3 Gene

No Compound Related Data Available

Transcripts for NXPH3 Gene

mRNA/cDNA for NXPH3 Gene

Unigene Clusters for NXPH3 Gene

Neurexophilin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH3 Gene

No ASD Table

Relevant External Links for NXPH3 Gene

GeneLoc Exon Structure for
NXPH3
ECgene alternative splicing isoforms for
NXPH3

Expression for NXPH3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NXPH3 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH3 Gene

This gene is overexpressed in Artery - Aorta (x7.9), Artery - Tibial (x4.8), Brain - Cerebellar Hemisphere (x4.7), and Brain - Cerebellum (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of NXPH3 Gene:

NXPH3

SOURCE GeneReport for Unigene cluster for NXPH3 Gene:

Hs.55069

mRNA Expression by UniProt/SwissProt for NXPH3 Gene:

O95157-NXPH3_HUMAN
Tissue specificity: Highest level in brain.

Evidence on tissue expression from TISSUES for NXPH3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NXPH3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPH3 Gene

Orthologs for NXPH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NXPH3 34 35
  • 94.05 (n)
cow
(Bos Taurus)
Mammalia NXPH3 34 35
  • 91.53 (n)
rat
(Rattus norvegicus)
Mammalia Nxph3 34
  • 89.95 (n)
mouse
(Mus musculus)
Mammalia Nxph3 34 16 35
  • 89.55 (n)
oppossum
(Monodelphis domestica)
Mammalia NXPH3 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NXPH3 34
  • 69.51 (n)
lizard
(Anolis carolinensis)
Reptilia NXPH3 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph3 34
  • 60.71 (n)
zebrafish
(Danio rerio)
Actinopterygii nxph2b 35
  • 45 (a)
ManyToMany
Species where no ortholog for NXPH3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH3 Gene

ENSEMBL:
Gene Tree for NXPH3 (if available)
TreeFam:
Gene Tree for NXPH3 (if available)

Paralogs for NXPH3 Gene

Paralogs for NXPH3 Gene

(3) SIMAP similar genes for NXPH3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NXPH3: view

Variants for NXPH3 Gene

Sequence variations from dbSNP and Humsavar for NXPH3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000007055 -- 49,582,191(+) TGATG(-/C)CCCCC utr-variant-3-prime
rs1000060935 -- 49,582,385(+) TTTAG(C/T)GGTCC utr-variant-3-prime
rs1000068528 -- 49,577,004(+) ATACT(C/G)TCGTG intron-variant
rs1000222754 -- 49,581,233(+) CAGTG(G/T)CACCT utr-variant-3-prime
rs1000349968 -- 49,575,384(+) AAAAG(G/T)ATCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NXPH3 Gene

Variant ID Type Subtype PubMed ID
nsv2078 CNV deletion 18451855

Variation tolerance for NXPH3 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPH3 Gene

Human Gene Mutation Database (HGMD)
NXPH3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXPH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPH3 Gene

Disorders for NXPH3 Gene

Relevant External Links for NXPH3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXPH3

No disorders were found for NXPH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPH3 Gene

Publications for NXPH3 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M. … Suedhof T.C. (J. Neurosci. 1998) 2 3 4 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4 64

Products for NXPH3 Gene

Sources for NXPH3 Gene

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