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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXPH3 Gene

protein-coding   GIFtS: 49
GCID: GC17P047653

neurexophilin 3

  Search for NXPH3
in our new
 Human Malady Compendium 
Biological research products
for NXPH3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neurexophilin 31 2
NPH31 2 3
Neurexophilin-31
KIAA11593

External Ids:    HGNC: 80771   Entrez Gene: 112482   Ensembl: ENSG000001825757   OMIM: 6046365   UniProtKB: O951573   

Export aliases for NXPH3 gene to outside databases

Previous GC identifers: GC17P047364 GC17P050133 GC17P047995 GC17P048127 GC17P045008 GC17P043018


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157
Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity)

Gene Wiki entry for NXPH3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NXPH3 gene promoter:
         MAZR   GCNF   GATA-2   POU2F1   CP2   HOXA5   POU2F1a   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXPH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NXPH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q

NXPH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXPH3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P047653:  view genomic region     (about GC identifiers)

Start:
47,653,220 bp from pter      End:
47,661,189 bp from pter
Size:
7,970 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157 (See protein sequence)
Recommended Name: Neurexophilin-3 precursor  
Size: 252 amino acids; 28127 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q8NDC3 Q8TBF6 Q9ULR1

Explore the universe of human proteins at neXtProt for NXPH3: NX_O95157

Post-translational modifications:

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain
  • in neuron-like cells (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95157

  • NXPH3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009156.2  
    ENSEMBL proteins: 
     ENSP00000329295   ENSP00000421168  

    Human Recombinant Protein Products: 
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    Novus Biologicals NXPH3 Protein
    Novus Biologicals NXPH3 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NXPH3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--


    NXPH3 for ontologies           About GeneDecksing



    NXPH3 Antibody Products: 
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    Uscn ELISAs and CLIAs for NXPH3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NXPH3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR010450 Neurexophilin
     IPR026845 NXPH/NXPE

    Graphical View of Domain Structure for InterPro Entry O95157

    ProtoNet protein and cluster: O95157

    1 Blocks protein family: IPB010450 Neurexophilin

    UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157
    Similarity: Belongs to the neurexophilin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157
    Function: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXPH3
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate NXPH3 (see all 47):
    hsa-miR-549 hsa-miR-328 hsa-miR-765 hsa-miR-516a-5p hsa-miR-764 hsa-miR-766 hsa-miR-4267 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidNXPH3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXPH3 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005102receptor binding IEA--


    NXPH3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for NXPH3:
     Decreased number of cells in m  Increased cell number in G1, a  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Nxph3tm1.1Mami for NXPH3
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nxph3):
     behavior/neurological  growth/size  mortality/aging  nervous system  normal 
     reproductive system 

    NXPH3 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXPH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for NXPH3 (O951571, 2, 3 ENSP000003292954) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-1752913,EBI-375543 MINT-8110587 I2D: score=3 STRING: ENSP00000361423
    CRKP461081, 3, ENSP000003005744EBI-1752913,EBI-886 I2D: score=2 STRING: ENSP00000300574
    TAB1Q157502, 3MINT-8260218 I2D: score=2 
    SRCP129311, 2, 3, ENSP000003509414EBI-1752913,EBI-621482 MINT-8113167 I2D: score=3 STRING: ENSP00000350941
    NCK1P163331, 3, ENSP000002889864EBI-1752913,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007218neuropeptide signaling pathway NAS9570794


    NXPH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXPH3
    Search CenterWatch for drugs/clinical trials and news about NXPH3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NXPH3 gene: 
    NM_007225.2  

    Unigene Cluster for NXPH3:

    Neurexophilin 3
    Hs.55069  [show with all ESTs]
    Unigene Representative Sequence: NM_007225
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328741(uc002ipa.3) ENST00000513748 ENST00000570453

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXPH3
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate NXPH3 (see all 47):
    hsa-miR-549 hsa-miR-328 hsa-miR-765 hsa-miR-516a-5p hsa-miR-764 hsa-miR-766 hsa-miR-4267 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidNXPH3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXPH3 (see all 7)
    OriGene shRNA RFP: NXPH3
    OriGene siRNA: NXPH3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXPH3
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH3
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPH3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPH3

    Additional cDNA sequence: 

    AB032985.1 AF043468.1 AK308928.1 AL834282.1 AY358526.1 BC022541.1 

    1 DOTS entry:

    DT.202259 

    24/48 AceView cDNA sequences (see all 48):

    AY358526 AL535326 AI369443 BM684247 CR600551 BM719416 BF221827 BM560110 
    AB032985 BF969281 BX283684 AA338636 BM810584 BM930998 AL834282 BX423307 
    AI937333 H38679 AI367153 AW449723 BX100608 NM_007225 BC022541 AF043468 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXPH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTGGATCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NXPH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXPH3

    SOURCE GeneReport for Unigene cluster: Hs.55069

    UniProtKB/Swiss-Prot: NXPH3_HUMAN, O95157
    Tissue specificity: Highest level in brain

        SABiosciences Custom PCR Arrays for NXPH3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NXPH3 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NXPH31 neurexophilin 3 69.15(n)
    63.6(a)
      429523  XM_427080.2  XP_427080.1 
    lizard
    (Anolis carolinensis)
    Reptilia NXPH36
    --
    66(a)
    1 ↔ 1
    6(76670860-76671324)
    zebrafish
    (Danio rerio)
    Actinopterygii BX649458.16
    --
    47(a)
    1 ↔ 1
    3(20294524-20354236)


    ENSEMBL Gene Tree for NXPH3 (if available)
    TreeFam Gene Tree for NXPH3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXPH3 gene
    NXPH42  NXPH12  NXPH22  
    3 SIMAP similar genes for NXPH3 using alignment to 3 protein entries:     NXPH3_HUMAN (see all proteins):
    NXPH1    Nbla00697    NXPH2

    NXPH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 NCBI SNPs in NXPH3 are shown (see all 167    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs747644641,2
    --43016828(+) GGGGGA/G/TTCTTT 1 -- us2k11NA 2
    rs795050841,2
    F,--43017128(+) CCACCG/ATGCTC 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs773606701,2
    C,F,--43017213(+) CAGGAC/TTTGAC 1 -- us2k11Minor allele frequency- T:0.21WA 118
    rs765435731,2
    F,--43017324(+) TCTCAG/TATCAG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1495288771,2
    --47651301(+) GGCACA/GGCGGA 2 -- nc-transcript-variantus2k10--------
    rs1862141211,2
    --47651311(+) ACAGGC/TTCGGC 2 -- us2k1 nc-transcript-variant0--------
    rs1910534681,2
    --47651400(+) AGCCTA/GGCAGG 2 -- nc-transcript-variantus2k10--------
    rs1486529151,2
    --47651437(+) AAGTGA/GAGGAG 2 -- us2k10--------
    rs1443075431,2
    --47651540(+) GAACAG/TATCAG 2 -- us2k10--------
    rs564006921,2
    C,--47651632(+) GAAAAC/TCTGTG 2 -- us2k14Minor allele frequency- T:0.10NA WA EA 360

    HapMap Linkage Disequilibrium report for NXPH3 (47653220 - 47661189 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NXPH3: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NXPH3 for disorders           About MalaCards

    NXPH3 for disorders           About GeneDecksing

    OMIM gene information: 604636    OMIM disorders: --


    Export disorders for NXPH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXPH3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with NXPH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PubMed id 9570794)1, 2, 3 Missler M. and Suedhof T.C. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    8. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11248 HGNC: 8077 AceView: NXPH3 Ensembl:ENSG00000182575 euGenes: HUgn11248
    ECgene: NXPH3 H-InvDB: NXPH3

    (According to HUGE)
    About This Section
    HUGE: KIAA1159

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXPH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NXPH3 gene:
    Search GeneIP for patents involving NXPH3

    GeneCards and IP:
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     Browse OriGene Antibodies   OriGene shRNA RFP for NXPH3  
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NXPH3
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     GenScript Custom Purified and Recombinant Proteins Services for NXPH3 GenScript cDNA clones with any tag delivered in your preferred vector for NXPH3
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     Regulatory tfbs in NXPH3 promoter
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     NXPH3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NXPH3
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH3
     SwitchGear 3'UTR luciferase reporter plasmids for NXPH3
     SwitchGear Promoter luciferase reporter plasmids for NXPH3
     Search ThermoFisher Antibodies for NXPH3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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