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Aliases for NXPH2 Gene

Aliases for NXPH2 Gene

  • Neurexophilin 2 2 3 5
  • NPH2 3 4

External Ids for NXPH2 Gene

Previous GeneCards Identifiers for NXPH2 Gene

  • GC02M137117
  • GC02M137736
  • GC02M139450
  • GC02M139639
  • GC02M139262
  • GC02M139144
  • GC02M131418

Summaries for NXPH2 Gene

GeneCards Summary for NXPH2 Gene

NXPH2 (Neurexophilin 2) is a Protein Coding gene. An important paralog of this gene is NXPH4.

UniProtKB/Swiss-Prot for NXPH2 Gene

  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH2 Gene

Genomics for NXPH2 Gene

Regulatory Elements for NXPH2 Gene

Enhancers for NXPH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NXPH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXPH2 Gene

138,669,157 bp from pter
138,780,348 bp from pter
111,192 bases
Minus strand

Genomic View for NXPH2 Gene

Genes around NXPH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH2 Gene

Proteins for NXPH2 Gene

  • Protein details for NXPH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7WP24
    • Q494R1
    • Q75QC3

    Protein attributes for NXPH2 Gene

    264 amino acids
    Molecular mass:
    29938 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH2 Gene

Proteomics data for NXPH2 Gene at MOPED

Post-translational modifications for NXPH2 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn 86, Asn 139, Asn 149, and Asn 155
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH2 Gene

Domains & Families for NXPH2 Gene

Protein Domains for NXPH2 Gene


Suggested Antigen Peptide Sequences for NXPH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neurexophilin family.
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH2: view

No data available for Gene Families for NXPH2 Gene

Function for NXPH2 Gene

Molecular function for NXPH2 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
genes like me logo Genes that share phenotypes with NXPH2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NXPH2

miRNA for NXPH2 Gene

miRTarBase miRNAs that target NXPH2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPH2 Gene

Localization for NXPH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH2 Gene


Subcellular locations from

Jensen Localization Image for NXPH2 Gene COMPARTMENTS Subcellular localization image for NXPH2 gene
Compartment Confidence
extracellular 5
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NXPH2 Gene

Pathways & Interactions for NXPH2 Gene

SuperPathways for NXPH2 Gene

No Data Available

Interacting Proteins for NXPH2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000272641 O95156-NXPH2_HUMAN for NXPH2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NXPH2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NXPH2 Gene

Drugs & Compounds for NXPH2 Gene

No Compound Related Data Available

Transcripts for NXPH2 Gene

mRNA/cDNA for NXPH2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPH2 Gene

Neurexophilin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH2 Gene

No ASD Table

Relevant External Links for NXPH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXPH2 Gene

mRNA expression in normal human tissues for NXPH2 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x9.0), Brain - Frontal Cortex (BA9) (x7.5), and Ovary (x6.1).

SOURCE GeneReport for Unigene cluster for NXPH2 Gene Hs.435019

mRNA Expression by UniProt/SwissProt for NXPH2 Gene

Tissue specificity: Expressed in brain and kidney.
genes like me logo Genes that share expression patterns with NXPH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NXPH2 Gene

Orthologs for NXPH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXPH2 35
  • 92.3 (n)
  • 97.35 (a)
NXPH2 36
  • 97 (a)
(Canis familiaris)
Mammalia NXPH2 35
  • 92.38 (n)
  • 96.33 (a)
NXPH2 36
  • 95 (a)
(Mus musculus)
Mammalia Nxph2 35
  • 85.06 (n)
  • 90.04 (a)
Nxph2 16
Nxph2 36
  • 90 (a)
(Pan troglodytes)
Mammalia NXPH2 35
  • 99.87 (n)
  • 100 (a)
NXPH2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nxph2 35
  • 84.56 (n)
  • 87.7 (a)
(Monodelphis domestica)
Mammalia NXPH2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia NXPH2 36
  • 73 (a)
(Gallus gallus)
Aves NXPH2 35
  • 80.93 (n)
  • 88.26 (a)
NXPH2 36
  • 88 (a)
(Anolis carolinensis)
Reptilia NXPH2 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph2 35
  • 73.38 (n)
  • 80.23 (a)
(Danio rerio)
Actinopterygii nxph2a 35
  • 66.93 (n)
  • 70.7 (a)
nxph2a 36
  • 66 (a)
Species with no ortholog for NXPH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH2 Gene

Gene Tree for NXPH2 (if available)
Gene Tree for NXPH2 (if available)

Paralogs for NXPH2 Gene

Paralogs for NXPH2 Gene

(4) SIMAP similar genes for NXPH2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NXPH2: view

Variants for NXPH2 Gene

Sequence variations from dbSNP and Humsavar for NXPH2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs952174 -- 138,691,260(+) CAAAA(C/T)TGAGG intron-variant
rs2938929 -- 138,687,518(-) aatta(C/T)catca intron-variant
rs2944441 -- 138,687,521(-) agaaa(C/T)tacca intron-variant
rs4954717 -- 138,694,802(+) AGTCA(A/G)CCACA intron-variant
rs4954718 -- 138,709,542(+) cacct(C/G)aagtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXPH2 Gene

Variant ID Type Subtype PubMed ID
nsv7329 OTHER Inversion 18451855
nsv875159 CNV Gain 21882294
nsv524273 CNV Gain 19592680
nsv525196 CNV Loss 19592680

Variation tolerance for NXPH2 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NXPH2 Gene

Disorders for NXPH2 Gene

Relevant External Links for NXPH2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NXPH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPH2 Gene

Publications for NXPH2 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M. … Suedhof T.C. (J. Neurosci. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. (PMID: 21956439) Zuo L. … Luo X. (Neuropsychopharmacology 2012) 3
  4. Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. (PMID: 19478329) Aston K.I. … Carrell D.T. (J. Androl. 2009) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for NXPH2 Gene

Sources for NXPH2 Gene