NXPH2 Gene
protein-coding GIFtS: 45
GCID: GC02M139450
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|
neurexophilin 2
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Aliases
for NXPH2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neurexophilin 21 2 | | NPH21 2 3 | | Neurexophilin-21 |
Export aliases for NXPH2 gene to outside databasesPrevious GC identifers: GC02M137117 GC02M137736 GC02M139639 GC02M139262 GC02M139144 GC02M131418 |
Summaries
for NXPH2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NXPH2_HUMAN, O95156Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins andpossibly other receptors (Potential)
|
Genomic Views
for NXPH2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NXPH2 gene promoter:
Tal-1beta NF-AT Evi-1 MEF-2A NF-AT2 NF-AT3 aMEF-2 ITF-2 Pax-4a NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NXPH2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPH2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q22.1 Ensembl cytogenetic band: 2q22.1 HGNC cytogenetic band: 2q22.1NXPH2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M139450: view genomic region
(about GC identifiers)
Start:
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139,426,727 bp from pter |
End:
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139,537,918 bp from pter |
Size:
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111,192 bases |
Orientation:
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minus strand |
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Proteins
for NXPH2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NXPH2_HUMAN, O95156 (See
protein sequence)Recommended Name: Neurexophilin-2 precursor Size: 264 amino acids; 29938 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B7WP24 Q494R1 Q75QC3Explore the universe of human proteins at neXtProt for NXPH2: NX_O95156
Post-translational modifications:
May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domainin neuron-like cells (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95156
NXPH2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009157.1
ENSEMBL proteins: ENSP00000272641
Human Recombinant Protein Products for NXPH2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- |
NXPH2 for ontologies About GeneDecksing
NXPH2 Antibody Products:
Assay Products for NXPH2: |
Protein
Domains /
Families
for NXPH2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NXPH2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95156ProtoNet protein and cluster: O95156 1 Blocks protein family: IPB010450 Neurexophilin
UniProtKB/Swiss-Prot: NXPH2_HUMAN, O95156Similarity: Belongs to the neurexophilin family |
Function
for NXPH2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NXPH2_HUMAN, O95156Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins andpossibly other receptors (Potential) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
NXPH2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NXPH2 (NM_007226) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPH2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH2 |
|
Pathways & Interactions
for NXPH2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXPH2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for NXPH2 (O951563 ENSP000002726414) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007218 | neuropeptide signaling pathway |
NAS | 9570794 |
NXPH2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NXPH2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NXPH2
Search CenterWatch for drugs/clinical trials and news about NXPH2
|
Transcripts
for NXPH2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NXPH2 gene: NM_007226.2 Unigene Cluster for NXPH2: Neurexophilin 2 Hs.435019 [show with all ESTs]Unigene Representative Sequence: NM_0072261 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000272641(uc002tvi.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NXPH2 (NM_007226) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPH2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH2 |
Additional cDNA sequence: AB162675.1 AF043467.1 BC101461.1 BC101462.1 BC101463.1 BC104741.1 3 DOTS entries: DT.105533 DT.440922 DT.92416554 19 AceView cDNA sequences: BM722360 F01760 F01766 F05498 BU740195 AB162675 Z42233 BV175274 AW015458 AW418941 BG429614 NM_007226 AI765540 AI039520 AF043467 H17216 CA336449 R57197 AW473162
GeneLoc Exon Structure
|
Expression
for NXPH2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NXPH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTGTAAT
About this image
See NXPH2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NXPH2
SOURCE GeneReport for Unigene cluster: Hs.435019
UniProtKB/Swiss-Prot: NXPH2_HUMAN, O95156Tissue specificity: Expressed in brain and kidney
SABiosciences Custom PCR Arrays for NXPH2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXPH2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NXPH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPH2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH2 |
Orthologs
for NXPH2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NXPH2 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for NXPH2 (if available)
TreeFam Gene Tree for NXPH2 (if available) |
Paralogs
for NXPH2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NXPH2 gene
- NXPH42 NXPH32 NXPH12
4 SIMAP similar genes for NXPH2 using alignment to 2 protein entries: NXPH2_HUMAN (see all proteins):NXPH1 Nbla00697 NXPH3 NXPH4
NXPH2 for paralogs About GeneDecksing
|
Genomic Variants
for NXPH2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NXPH2 (139426727 - 139537918 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NXPH2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPH2 |
|
Disorders
/ Diseases
for NXPH2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NXPH2 for disorders About GeneDecksing
OMIM gene information: 604635
OMIM disorders: --
2  diseases for NXPH2: About MalaCardsazoospermia neuronitis
Export disorders for NXPH2 gene to outside databases
|
Publications
for NXPH2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NXPH2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NXPH2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PubMed id 9570794)1, 2, 3 Missler M. and Suedhof T.C. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genome-wide association study of alcohol dependence im plicates KIAA0040 on chromosome 1q. (PubMed id 21956439)1 Zuo L....Luo X. (2012)
- Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. (PubMed id 19478329)1 Aston K.I. and Carrell D.T. (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Structure and evolution of neurexophilin. (PubMed id 8699246)1 Petrenko A.G....Sudhof T.C. (1996)
|
External Searches for NXPH2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NXPH2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NXPH2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NXPH2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NXPH2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NXPH2 gene:
Search GeneIP for patents involving NXPH2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NXPH2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXPH2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXPH2 | | | OriGene Protein Over-expression Lysate for NXPH2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NXPH2 | | OriGene 3'-UTR Clone for NXPH2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPH2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NXPH2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPH2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPH2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXPH2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPH2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPH2 |
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 | | | NXPH2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH2 |
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