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Aliases for NXPH2 Gene

Aliases for NXPH2 Gene

  • Neurexophilin 2 2 3
  • NPH2 3 4
  • Neurexophilin-2 3

External Ids for NXPH2 Gene

Previous GeneCards Identifiers for NXPH2 Gene

  • GC02M137117
  • GC02M137736
  • GC02M139450
  • GC02M139639
  • GC02M139262
  • GC02M139144
  • GC02M131418

Summaries for NXPH2 Gene

GeneCards Summary for NXPH2 Gene

NXPH2 (Neurexophilin 2) is a Protein Coding gene. An important paralog of this gene is NXPH4.

UniProtKB/Swiss-Prot for NXPH2 Gene

  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH2 Gene

Genomics for NXPH2 Gene

Regulatory Elements for NXPH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NXPH2 Gene

Start:
138,669,157 bp from pter
End:
138,780,348 bp from pter
Size:
111,192 bases
Orientation:
Minus strand

Genomic View for NXPH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXPH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH2 Gene

Proteins for NXPH2 Gene

  • Protein details for NXPH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95156-NXPH2_HUMAN
    Recommended name:
    Neurexophilin-2
    Protein Accession:
    O95156
    Secondary Accessions:
    • B7WP24
    • Q494R1
    • Q75QC3

    Protein attributes for NXPH2 Gene

    Size:
    264 amino acids
    Molecular mass:
    29938 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH2 Gene

Proteomics data for NXPH2 Gene at MOPED

Post-translational modifications for NXPH2 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn86, Asn139, Asn149, and Asn155
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH2 Gene

Domains for NXPH2 Gene

Protein Domains for NXPH2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NXPH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95156

UniProtKB/Swiss-Prot:

NXPH2_HUMAN :
  • O95156
Family:
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH2: view

No data available for Gene Families for NXPH2 Gene

Function for NXPH2 Gene

Molecular function for NXPH2 Gene

UniProtKB/Swiss-Prot Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Gene Ontology (GO) - Molecular Function for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NXPH2: view

Animal Model Products

miRNA for NXPH2 Gene

miRTarBase miRNAs that target NXPH2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NXPH2 Gene

Localization for NXPH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXPH2 Gene COMPARTMENTS Subcellular localization image for NXPH2 gene
Compartment Confidence
extracellular 5
cytosol 1
golgi apparatus 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH2: view

Pathways for NXPH2 Gene

SuperPathways for NXPH2 Gene

No Data Available

Interacting Proteins for NXPH2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000272641%0d%0a9606.ENSP00000385142%0d%0a
Selected Interacting proteins: ENSP00000272641 O95156-NXPH2_HUMAN for NXPH2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 9570794
genes like me logo Genes that share ontologies with NXPH2: view

No data available for Pathways by source for NXPH2 Gene

Transcripts for NXPH2 Gene

mRNA/cDNA for NXPH2 Gene

(19) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPH2 Gene

Neurexophilin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXPH2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NXPH2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH2 Gene

No ASD Table

Relevant External Links for NXPH2 Gene

GeneLoc Exon Structure for
NXPH2
ECgene alternative splicing isoforms for
NXPH2

Expression for NXPH2 Gene

mRNA expression in normal human tissues for NXPH2 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (9.0), Brain - Frontal Cortex (BA9) (7.5), and Ovary (6.1).

SOURCE GeneReport for Unigene cluster for NXPH2 Gene Hs.435019

mRNA Expression by UniProt/SwissProt for NXPH2 Gene

O95156-NXPH2_HUMAN
Tissue specificity: Expressed in brain and kidney
genes like me logo Genes that share expressions with NXPH2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for NXPH2 Gene

Orthologs for NXPH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXPH2 35
  • 99.87 (n)
  • 100 (a)
NXPH2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NXPH2 35
  • 92.3 (n)
  • 97.35 (a)
NXPH2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXPH2 35
  • 92.38 (n)
  • 96.33 (a)
NXPH2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nxph2 35
  • 85.06 (n)
  • 90.04 (a)
Nxph2 16
Nxph2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NXPH2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NXPH2 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxph2 35
  • 84.56 (n)
  • 87.7 (a)
chicken
(Gallus gallus)
Aves NXPH2 35
  • 80.93 (n)
  • 88.26 (a)
NXPH2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NXPH2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph2 35
  • 73.38 (n)
  • 80.23 (a)
zebrafish
(Danio rerio)
Actinopterygii nxph2a 35
  • 66.93 (n)
  • 70.7 (a)
nxph2a 36
  • 66 (a)
OneToOne
Species with no ortholog for NXPH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH2 Gene

ENSEMBL:
Gene Tree for NXPH2 (if available)
TreeFam:
Gene Tree for NXPH2 (if available)

Paralogs for NXPH2 Gene

Paralogs for NXPH2 Gene

Selected SIMAP similar genes for NXPH2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NXPH2: view

Variants for NXPH2 Gene

Sequence variations from dbSNP and Humsavar for NXPH2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs952174 -- 138,691,260(+) CAAAA(C/T)TGAGG intron-variant
rs2139991 -- 138,691,268(+) AGGCC(C/T)TTAAA intron-variant
rs2177070 -- 138,690,161(+) TGTCC(A/G)CCTTC intron-variant
rs2938929 -- 138,687,518(-) aatta(C/T)catca intron-variant
rs2944441 -- 138,687,521(-) agaaa(C/T)tacca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXPH2 Gene

Variant ID Type Subtype PubMed ID
nsv7329 OTHER Inversion 18451855
nsv875159 CNV Gain 21882294
nsv524273 CNV Gain 19592680
nsv525196 CNV Loss 19592680

Relevant External Links for NXPH2 Gene

HapMap Linkage Disequilibrium report
NXPH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPH2 Gene

Disorders for NXPH2 Gene

Relevant External Links for NXPH2

Genetic Association Database (GAD)
NXPH2
genes like me logo Genes that share disorders with NXPH2: view

No data available for UniProtKB/Swiss-Prot for NXPH2 Gene

Publications for NXPH2 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M. … Suedhof T.C. (J. Neurosci. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. (PMID: 19478329) Aston K.I. … Carrell D.T. (J. Androl. 2009) 3 48
  4. Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. (PMID: 21956439) Zuo L. … Luo X. (Neuropsychopharmacology 2012) 3 48
  5. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PMID: 17903298) Meigs J.B. … Dupuis J. (BMC Med. Genet. 2007) 48

Products for NXPH2 Gene

Sources for NXPH2 Gene

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