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Aliases for NXPH2 Gene

Aliases for NXPH2 Gene

  • Neurexophilin 2 2 3 5
  • NPH2 3 4
  • Neurexophilin-2 3

External Ids for NXPH2 Gene

Previous GeneCards Identifiers for NXPH2 Gene

  • GC02M137117
  • GC02M137736
  • GC02M139450
  • GC02M139639
  • GC02M139262
  • GC02M139144
  • GC02M131418

Summaries for NXPH2 Gene

GeneCards Summary for NXPH2 Gene

NXPH2 (Neurexophilin 2) is a Protein Coding gene. An important paralog of this gene is NXPH1.

UniProtKB/Swiss-Prot for NXPH2 Gene

  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH2 Gene

Genomics for NXPH2 Gene

Regulatory Elements for NXPH2 Gene

Enhancers for NXPH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F138707 0.3 FANTOM5 18.9 +73.3 73251 0.0 NXPH2 PIR53619 GC02M138620
GH02F138777 0.7 ENCODE 0.8 +2.2 2154 0.5 SOX13 GATAD2A SOX5 ATF1 TEAD1 FOXA3 TEAD4 MAX HMG20A FEZF1 NXPH2 GC02M138620 PIR53619
GH02F138814 0.5 ENCODE 0.3 -34.4 -34398 0.2 CTCF FOXA3 RAD21 NXPH2 RN7SKP286
GH02F138709 0.7 Ensembl ENCODE 0.2 +72.6 72590 1.2 JUND HLF FOS NXPH2 PIR53619 GC02M138620
GH02F138744 0.4 ENCODE 0.3 +34.9 34883 2.3 ZNF263 NXPH2 GC02M138620 PIR53619
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NXPH2 on UCSC Golden Path with GeneCards custom track

Promoters for NXPH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001827627 -52 801 CTCF ZNF2 HIC1 ZFHX2 GLIS2 ZBTB48 ZNF600 EZH2 EGR2 L3MBTL2

Genomic Location for NXPH2 Gene

Chromosome:
2
Start:
138,669,157 bp from pter
End:
138,780,348 bp from pter
Size:
111,192 bases
Orientation:
Minus strand

Genomic View for NXPH2 Gene

Genes around NXPH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH2 Gene

Proteins for NXPH2 Gene

  • Protein details for NXPH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95156-NXPH2_HUMAN
    Recommended name:
    Neurexophilin-2
    Protein Accession:
    O95156
    Secondary Accessions:
    • B7WP24
    • Q494R1
    • Q75QC3

    Protein attributes for NXPH2 Gene

    Size:
    264 amino acids
    Molecular mass:
    29938 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH2 Gene

Post-translational modifications for NXPH2 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn 86, Asn 139, Asn 149, and Asn 155
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH2 Gene

Domains & Families for NXPH2 Gene

Protein Domains for NXPH2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NXPH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95156

UniProtKB/Swiss-Prot:

NXPH2_HUMAN :
  • Belongs to the neurexophilin family.
Family:
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH2: view

No data available for Gene Families for NXPH2 Gene

Function for NXPH2 Gene

Molecular function for NXPH2 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Gene Ontology (GO) - Molecular Function for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with NXPH2: view
genes like me logo Genes that share phenotypes with NXPH2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NXPH2

miRNA for NXPH2 Gene

miRTarBase miRNAs that target NXPH2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPH2 Gene

Localization for NXPH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPH2 gene
Compartment Confidence
extracellular 5
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH2: view

Pathways & Interactions for NXPH2 Gene

SuperPathways for NXPH2 Gene

No Data Available

Interacting Proteins for NXPH2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000272641%0d%0a9606.ENSP00000385142%0d%0a
Selected Interacting proteins: ENSP00000272641 O95156-NXPH2_HUMAN for NXPH2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 9570794
genes like me logo Genes that share ontologies with NXPH2: view

No data available for Pathways by source and SIGNOR curated interactions for NXPH2 Gene

Transcripts for NXPH2 Gene

mRNA/cDNA for NXPH2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPH2 Gene

Neurexophilin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH2 Gene

No ASD Table

Relevant External Links for NXPH2 Gene

GeneLoc Exon Structure for
NXPH2
ECgene alternative splicing isoforms for
NXPH2

Expression for NXPH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NXPH2 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x9.0), Brain - Frontal Cortex (BA9) (x7.5), and Ovary (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of NXPH2 Gene:

NXPH2

SOURCE GeneReport for Unigene cluster for NXPH2 Gene:

Hs.435019

mRNA Expression by UniProt/SwissProt for NXPH2 Gene:

O95156-NXPH2_HUMAN
Tissue specificity: Expressed in brain and kidney.
genes like me logo Genes that share expression patterns with NXPH2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NXPH2 Gene

Orthologs for NXPH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXPH2 34 35
  • 99.87 (n)
oppossum
(Monodelphis domestica)
Mammalia NXPH2 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXPH2 34 35
  • 92.38 (n)
cow
(Bos Taurus)
Mammalia NXPH2 34 35
  • 92.3 (n)
mouse
(Mus musculus)
Mammalia Nxph2 34 16 35
  • 85.06 (n)
rat
(Rattus norvegicus)
Mammalia Nxph2 34
  • 84.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NXPH2 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves NXPH2 34 35
  • 80.93 (n)
lizard
(Anolis carolinensis)
Reptilia NXPH2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph2 34
  • 73.38 (n)
zebrafish
(Danio rerio)
Actinopterygii nxph2a 34 35
  • 66.93 (n)
Species where no ortholog for NXPH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH2 Gene

ENSEMBL:
Gene Tree for NXPH2 (if available)
TreeFam:
Gene Tree for NXPH2 (if available)

Paralogs for NXPH2 Gene

Paralogs for NXPH2 Gene

(4) SIMAP similar genes for NXPH2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NXPH2: view

Variants for NXPH2 Gene

Sequence variations from dbSNP and Humsavar for NXPH2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10153824 -- 138,700,884(+) ACTGC(A/T)GGAGA intron-variant
rs10164612 -- 138,677,796(+) TATTC(A/G)CTATA intron-variant
rs10171162 -- 138,733,722(+) TATCA(A/G)AGGAG intron-variant
rs10174964 -- 138,774,037(+) TAAAA(C/G)TATTT intron-variant
rs10178501 -- 138,736,412(+) ttgca(A/C)cctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXPH2 Gene

Variant ID Type Subtype PubMed ID
esv3412361 CNV insertion 20981092
nsv524273 CNV gain 19592680
nsv525196 CNV loss 19592680
nsv7329 OTHER inversion 18451855

Variation tolerance for NXPH2 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXPH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPH2 Gene

Disorders for NXPH2 Gene

Relevant External Links for NXPH2

Genetic Association Database (GAD)
NXPH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXPH2

No disorders were found for NXPH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPH2 Gene

Publications for NXPH2 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M. … Suedhof T.C. (J. Neurosci. 1998) 2 3 4 64
  2. Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. (PMID: 21956439) Zuo L. … Luo X. (Neuropsychopharmacology 2012) 3 46 64
  3. Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. (PMID: 19478329) Aston K.I. … Carrell D.T. (J. Androl. 2009) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for NXPH2 Gene

Sources for NXPH2 Gene

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