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Aliases for NXPH2 Gene

Aliases for NXPH2 Gene

  • Neurexophilin 2 2 3 5
  • NPH2 3 4
  • Neurexophilin-2 3

External Ids for NXPH2 Gene

Previous GeneCards Identifiers for NXPH2 Gene

  • GC02M137117
  • GC02M137736
  • GC02M139450
  • GC02M139639
  • GC02M139262
  • GC02M139144
  • GC02M131418

Summaries for NXPH2 Gene

GeneCards Summary for NXPH2 Gene

NXPH2 (Neurexophilin 2) is a Protein Coding gene. An important paralog of this gene is NXPH1.

UniProtKB/Swiss-Prot for NXPH2 Gene

  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Additional gene information for NXPH2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH2 Gene

Genomics for NXPH2 Gene

Regulatory Elements for NXPH2 Gene

Enhancers for NXPH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H138707 0.3 FANTOM5 18.9 +73.3 73251 0 NXPH2 PIR53619 GC02M138620
GH02H138777 0.7 ENCODE 0.7 +2.2 2154 0.5 SOX5 SOX13 GATAD2A FOXA2 ATF1 TEAD1 FOXA3 MAX HMG20A FEZF1 NXPH2 GC02M138620 PIR53619
GH02H138814 0.5 ENCODE 0.3 -34.4 -34398 0.2 CTCF FOXA3 RAD21 NXPH2 RN7SKP286
GH02H138752 0.5 ENCODE 0.3 +27.2 27201 2.1 NFIC LCORL NFIB NXPH2 GC02M138620 PIR53619
GH02H138708 0.7 Ensembl ENCODE 0.2 +71.3 71320 0.5 FOXA2 FOXK2 FEZF1 NXPH2 GC02M138620 PIR53619
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NXPH2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NXPH2 Gene

Genomic Locations for NXPH2 Gene
111,192 bases
Minus strand

Genomic View for NXPH2 Gene

Genes around NXPH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH2 Gene

Proteins for NXPH2 Gene

  • Protein details for NXPH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B7WP24
    • Q494R1
    • Q75QC3

    Protein attributes for NXPH2 Gene

    264 amino acids
    Molecular mass:
    29938 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH2 Gene

Post-translational modifications for NXPH2 Gene

  • May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells.
  • Glycosylation at Asn86, posLast=139139, Asn149, and posLast=155155
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPH2 Gene

Domains & Families for NXPH2 Gene

Gene Families for NXPH2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NXPH2 Gene


Suggested Antigen Peptide Sequences for NXPH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neurexophilin family.
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH2: view

Function for NXPH2 Gene

Molecular function for NXPH2 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Phenotypes From GWAS Catalog for NXPH2 Gene

Gene Ontology (GO) - Molecular Function for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with NXPH2: view
genes like me logo Genes that share phenotypes with NXPH2: view

miRNA for NXPH2 Gene

miRTarBase miRNAs that target NXPH2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPH2 Gene

Localization for NXPH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPH2 gene
Compartment Confidence
extracellular 5
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NXPH2 Gene

Pathways & Interactions for NXPH2 Gene

SuperPathways for NXPH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NXPH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway NAS 9570794
genes like me logo Genes that share ontologies with NXPH2: view

No data available for Pathways by source and SIGNOR curated interactions for NXPH2 Gene

Drugs & Compounds for NXPH2 Gene

No Compound Related Data Available

Transcripts for NXPH2 Gene

mRNA/cDNA for NXPH2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPH2 Gene

Neurexophilin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH2 Gene

No ASD Table

Relevant External Links for NXPH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXPH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NXPH2 Gene

mRNA differential expression in normal tissues according to GTEx for NXPH2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x9.0), Brain - Frontal Cortex (BA9) (x7.5), and Ovary (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of NXPH2 Gene:


SOURCE GeneReport for Unigene cluster for NXPH2 Gene:


mRNA Expression by UniProt/SwissProt for NXPH2 Gene:

Tissue specificity: Expressed in brain and kidney.
genes like me logo Genes that share expression patterns with NXPH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPH2 Gene

Orthologs for NXPH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NXPH2 33 34
  • 99.87 (n)
(Monodelphis domestica)
Mammalia NXPH2 34
  • 94 (a)
(Canis familiaris)
Mammalia NXPH2 33 34
  • 92.38 (n)
(Bos Taurus)
Mammalia NXPH2 33 34
  • 92.3 (n)
(Mus musculus)
Mammalia Nxph2 33 16 34
  • 85.06 (n)
(Rattus norvegicus)
Mammalia Nxph2 33
  • 84.56 (n)
(Ornithorhynchus anatinus)
Mammalia NXPH2 34
  • 73 (a)
(Gallus gallus)
Aves NXPH2 33 34
  • 80.93 (n)
(Anolis carolinensis)
Reptilia NXPH2 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph2 33
  • 73.38 (n)
(Danio rerio)
Actinopterygii nxph2a 33 34
  • 66.93 (n)
Species where no ortholog for NXPH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH2 Gene

Gene Tree for NXPH2 (if available)
Gene Tree for NXPH2 (if available)

Paralogs for NXPH2 Gene

Paralogs for NXPH2 Gene

(4) SIMAP similar genes for NXPH2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NXPH2: view

Variants for NXPH2 Gene

Sequence variations from dbSNP and Humsavar for NXPH2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000000247 -- 138,779,427(+) GAGAG(A/G)AGAGA intron-variant
rs1000010733 -- 138,735,477(+) GACTT(A/C)TTCAC intron-variant
rs1000014753 -- 138,721,479(+) TTTTA(A/T)TGGAG intron-variant
rs1000056237 -- 138,738,469(+) AGATA(C/T)ATCTA intron-variant
rs1000058245 -- 138,781,005(+) CGCCC(A/T)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NXPH2 Gene

Variant ID Type Subtype PubMed ID
nsv7329 OTHER inversion 18451855
nsv525196 CNV loss 19592680
nsv524273 CNV gain 19592680
esv3412361 CNV insertion 20981092

Variation tolerance for NXPH2 Gene

Residual Variation Intolerance Score: 30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPH2 Gene

Disorders for NXPH2 Gene

Relevant External Links for NXPH2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NXPH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPH2 Gene

Publications for NXPH2 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M … Südhof TC (The Journal of neuroscience : the official journal of the Society for Neuroscience 1998) 2 3 4 60
  2. Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. (PMID: 21956439) Zuo L … Luo X (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012) 3 45 60
  3. Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. (PMID: 19478329) Aston KI … Carrell DT (Journal of andrology 2009) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for NXPH2 Gene

Sources for NXPH2 Gene

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