NXPH1 Gene
protein-coding GIFtS : 54
GCID: GC07 P008440
neurexophilin 1
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Aliasesfor NXPH1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Neurexophilin 1 1 2 NPH12 3 Neurexophilin-11
Export aliases for NXPH1 gene to outside databases Previous GC identifers: GC07U990268 GC07P008117 GC07P008217 GC07P008246 GC07P008326
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Summariesfor NXPH1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for NXPH1 : This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417 Function : May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins andpossibly other receptors (Potential) Gene Wiki entry for NXPH1
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Genomic Viewsfor NXPH1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NXPH1 gene promoter: Nkx3-1 v2 AREB6 NRSF form 1 Nkx3-1 v3 Nkx3-1 v1 NRSF form 2 Other transcription factors Search SABiosciences Chromatin IP Primers for NXPH1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NXPH1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7p22 Ensembl cytogenetic band: 7p21.3 HGNC cytogenetic band: 7p22 NXPH1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P008440: view genomic region
(about GC identifiers )
Start:
8,473,585 bp from pter
End:
8,792,593 bp from pter
Size:
319,009 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 8,522,178-8,840,927
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Proteinsfor NXPH1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417 (See
protein sequence )Recommended Name: Neurexophilin-1 precursor Size : 271 amino acids; 31082 Da
Subcellular location : Secreted (Potential)
Secondary accessions : Q8NB31Explore the universe of human proteins at neXtProt for NXPH1: NX_P58417 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P58417 NXPH1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689958.1 ENSEMBL proteins: ENSP00000384551 ENSP00000404689 ENSP00000408216 ENSP00000391627 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
NXPH1 for ontologies About GeneDecksing NXPH1 Antibody Products: Assay Products for NXPH1:
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Protein
Domains / Familiesfor NXPH1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NXPH1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P58417 ProtoNet protein and cluster: P58417
1 Blocks protein family : IPB010450 Neurexophilin UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417 Similarity : Belongs to the neurexophilin family
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Functionfor NXPH1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417 Function : May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins andpossibly other receptors (Potential)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NXPH1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NXPH1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NXPH1 (NM_152745 ) Sino Biological Human cDNA Clone for NXPH1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPH1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NXPH1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005102 receptor binding
IEA --
NXPH1 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for NXPH1 :Animal Models: Mouse knock-out Nxph1 tm1Sud for NXPH1 3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nxph1) :
NXPH1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor NXPH1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXPH1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for NXPH1 (P58417 3 ENSP00000384551 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor NXPH1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for NXPH1 Search CenterWatch for drugs/clinical trials and news about NXPH1
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Transcriptsfor NXPH1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for NXPH1 gene: NM_152745.2 Unigene Cluster for NXPH1:
Neurexophilin 1 Hs.487564 [show with all ESTs ] Unigene Representative Sequence: NM_152745 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000405863 (uc003srv.3 uc011jxh.2 ) ENST00000438764 ENST00000429542 ENST00000497400 ENST00000417186 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NXPH1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NXPH1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: NXPH1 (NM_152745 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPH1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NXPH1
Additional cDNA sequence: AB047362.1 AB073665.1 AK091655.1 AK095624.1 AK296248.1 AK315141.1 BC047505.1
2 DOTS entries : DT.205841 DT.121099452
16 AceView cDNA sequences :
W01382 AI199172 NM_152745 AB047362 AA575925 BI752460 AK091655 BC047505 AK095624 BI669547 N62902 BX107562 AV707468 AU252730 T08230 AA057092 GeneLoc Exon Structure
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Expression for NXPH1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section NXPH1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAAGTTATAA
About this image NXPH1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See NXPH1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NXPH1 SOURCE GeneReport for Unigene cluster: Hs.487564 SABiosciences Custom PCR Arrays for NXPH1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NXPH1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat NXPH1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NXPH1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NXPH1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH1
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Orthologsfor NXPH1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for NXPH1 gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
NXPH11
neurexophilin 1
89.91(n) 96.31(a)
 
420582 XM_418683.3 XP_418683.2
lizard (Anolis carolinensis)
Reptilia
NXPH16
--
92(a)
1 ↔ 1
6(24138472-24139290)
zebrafish (Danio rerio)
Actinopterygii
Dr.148672
Transcribed sequence with weak similarity to protein more
80.09(n)
 
BM072575.1
ENSEMBL Gene Tree for NXPH1 (if available)TreeFam Gene Tree for NXPH1 (if available)
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Paralogsfor NXPH1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for NXPH1 gene NXPH4 2 NXPH3 2 NXPH2 2 4 SIMAP similar genes for NXPH1 using alignment to 3 protein entries: NXPH1_HUMAN (see all proteins ):Nbla00697 NXPH2 NXPH3 NXPH4
NXPH1 for paralogs About GeneDecksing
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Genomic Variantsfor NXPH1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for NXPH1 (8473585 - 8723585 bp, first 250kb of NXPH1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 13 variations for NXPH1 3 CNVs : 99859 10175 5396 10 Indels : 47401 47403 40949 99860 94367 62613 41838 28703 59423 81862 Human Gene Mutation Database (HGMD) : NXPH1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NXPH1
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Disorders
/ Diseasesfor NXPH1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NXPH1 for disorders About GeneDecksing
OMIM gene information: 604639
OMIM disorders : --4 diseases for NXPH1 : About MalaCards angelman syndrome prostate cancer neuroblastoma prostatitis Human Genome Epidemiology (HuGE) Navigator: NXPH1 (5 documents) Export disorders for NXPH1 gene to outside databases
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Publicationsfor NXPH1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for NXPH1 gene, integrated from 9 sources (see all 22 ): (articles sorted by number of sources associating them with NXPH1) Utopia : connect your pdf to the dynamic world of online information
Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PubMed id 9570794) 1 , 3, 9 Missler M. and Suedhof T.C. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961) 1 , 2 Ohira M.... Nakagawara A. (2003) The DNA sequence of human chromosome 7. (PubMed id 12853948) 1 , 2 Hillier L.W.... Wilson R.K. (2003) Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb. (PubMed id 12141453) 1 , 9 Clarris H.J....Key B. (2002) Genome-wide association study indicates variants assoc iated with insulin signaling and inflammation mediate lipoprotein responses to f enofibrate. (PubMed id 22890011) 1 Frazier-Wood A.C....Arnett D.K. (2012) Neurexophilin 1 suppresses the proliferation of hemat opoietic progenitor cells. (PubMed id 21628410) 1 Kinzfogl J....Broxmeyer H.E. (2011) Novel autosomal recessive nonsyndromic hearing impair ment locus DFNB90 maps to 7p22.1-p15.3. (PubMed id 21734401) 1 Ali G....Leal S.M. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010)
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External Searches for NXPH1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NXPH1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NXPH1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing NXPH1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for NXPH1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for NXPH1 gene: Search GeneIP for patents involving NXPH1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NXPH1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for NXPH1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for NXPH1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for NXPH1 OriGene Protein Over-expression Lysate for NXPH1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for NXPH1 OriGene 3'-UTR Clone for NXPH1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for NXPH1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for NXPH1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for NXPH1 OriGene Custom Protein Services for NXPH1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NXPH1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing NXPH1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat NXPH1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat NXPH1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat NXPH1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat NXPH1
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NXPH1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH1
ThermoFisher Antibody for NXPH1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat NXPH1
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Aliases for NXPH1
Databases for NXPH1
Disorders / Diseases for NXPH1
Domains / Families for NXPH1
Drugs / Compounds for NXPH1
Expression for NXPH1
Function for NXPH1
Genomic Views for NXPH1
Intellectual Property for NXPH1
Orthologs for NXPH1
Paralogs for NXPH1
Pathways / Interactions for NXPH1
Products for NXPH1
Proteins for NXPH1
Publications for NXPH1
Search Box for NXPH1
Summaries for NXPH1
Transcripts for NXPH1
Variants for NXPH1
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