Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NXPH1 Gene

protein-coding   GIFtS: 54
GCID: GC07P008440

Neurexophilin 1

  Search for NXPH1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Neurexophilin 11 2
NPH12 3
neurexophilin-12

External Ids:    HGNC: 206931   Entrez Gene: 300102   Ensembl: ENSG000001225847   OMIM: 6046395   UniProtKB: P584173   

Export aliases for NXPH1 gene to outside databases

Previous GC identifers: GC07U990268 GC07P008117 GC07P008217 GC07P008246 GC07P008326


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NXPH1 Gene:
This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal
domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal
domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion
between dendrites and axons. (provided by RefSeq, Jul 2008)

GeneCards Summary for NXPH1 Gene:
NXPH1 (neurexophilin 1) is a protein-coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is NXPH4.

UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417
Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and
possibly other receptors (Potential)

Gene Wiki entry for NXPH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NXPH1 gene promoter:
         Nkx3-1 v2   AREB6   NRSF form 1   Nkx3-1 v3   Nkx3-1 v1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NXPH1 promoter sequence
   Search Chromatin IP Primers for NXPH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NXPH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p22

NXPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXPH1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P008440:  view genomic region     (about GC identifiers)

Start:
8,473,585 bp from pter      End:
8,792,593 bp from pter
Size:
319,009 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 8,522,178-8,840,927     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417 (See protein sequence)
Recommended Name: Neurexophilin-1 precursor  
Size: 271 amino acids; 31082 Da
Secondary accessions: Q8NB31

Explore the universe of human proteins at neXtProt for NXPH1: NX_P58417

Explore proteomics data for NXPH1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn23, Asn68, Asn93, Asn146, Asn156, Asn162
  • Modification sites at PhosphoSitePlus

  • See NXPH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689958.1  
    ENSEMBL proteins: 
     ENSP00000384551   ENSP00000404689   ENSP00000408216   ENSP00000473269  

    NXPH1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NXPH1 (Neurexophilin-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NXPH1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NXPH1
    GenScript Custom Purified and Recombinant Proteins Services for NXPH1
    Novus Biologicals NXPH1 Protein
    Novus Biologicals NXPH1 Lysate
    Sino Biological Recombinant Protein for NXPH1
    Sino Biological Cell Lysate for NXPH1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NXPH1

     
    Search eBioscience for Proteins for NXPH1 

    NXPH1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NXPH1 (Neurexophilin-1)
    OriGene Antibodies for NXPH1
    OriGene Custom Antibody Services for NXPH1
    Novus Biologicals NXPH1 Antibodies
    Abcam antibodies for NXPH1
    Cloud-Clone Corp. Antibodies for NXPH1
    ThermoFisher Antibody for NXPH1
    LSBio Antibodies in human, mouse, rat for NXPH1

    NXPH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NXPH1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NXPH1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NXPH1
    Cloud-Clone Corp. CLIAs for NXPH1
    Search eBioscience for ELISAs for NXPH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR010450 Neurexophilin
     IPR026845 NXPH/NXPE

    Graphical View of Domain Structure for InterPro Entry P58417

    ProtoNet protein and cluster: P58417

    1 Blocks protein domain: IPB010450 Neurexophilin

    UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417
    Similarity: Belongs to the neurexophilin family


    Find genes that share domains with NXPH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXPH1_HUMAN, P58417
    Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and
    possibly other receptors (Potential)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--
         
    Find genes that share ontologies with NXPH1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NXPH1:
     Increased G1 DNA content  Increased cell size 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nxph1):
     growth/size/body  mortality/aging  reproductive system 

    Find genes that share phenotypes with NXPH1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nxph1tm1Sud for NXPH1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NXPH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NXPH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXPH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NXPH1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NXPH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NXPH1 (see all 25):
    hsa-miR-24-1* hsa-miR-15a hsa-miR-485-3p hsa-miR-346 hsa-miR-500a hsa-miR-24-2* hsa-miR-424 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidNXPH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NXPH1
    Predesigned siRNA for gene silencing in human, mouse, rat NXPH1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NXPH1

    Clone
    Products:
         
    OriGene clones in human, mouse for NXPH1 (see all 6)
    OriGene ORF clones in mouse, rat for NXPH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NXPH1 (NM_152745)
    Sino Biological Human cDNA Clone for NXPH1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXPH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NXPH1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NXPH1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NXPH1_HUMAN, P58417: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    lysosome1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with NXPH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NXPH1
    Interactions:

        Search GeneGlobe Interaction Network for NXPH1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NXPH1 (P584173 ENSP000003845514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRXN1Q9ULB13, ENSP000003851424I2D: score=1 STRING: ENSP00000385142
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NXPH1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NXPH1 gene: 
    NM_152745.2  

    Unigene Cluster for NXPH1:

    Neurexophilin 1
    Hs.487564  [show with all ESTs]
    Unigene Representative Sequence: NM_152745
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000405863(uc003srv.3 uc011jxh.2) ENST00000438764 ENST00000429542
    ENST00000497400 ENST00000602349
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NXPH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NXPH1 (see all 25):
    hsa-miR-24-1* hsa-miR-15a hsa-miR-485-3p hsa-miR-346 hsa-miR-500a hsa-miR-24-2* hsa-miR-424 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidNXPH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NXPH1
    Predesigned siRNA for gene silencing in human, mouse, rat NXPH1
    Clone
    Products:
         
    OriGene clones in human, mouse for NXPH1 (see all 6)
    OriGene ORF clones in mouse, rat for NXPH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NXPH1 (NM_152745)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXPH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NXPH1
    OriGene qSTAR qPCR primer pairs in human, mouse for NXPH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXPH1
      QuantiTect SYBR Green Assays in human, mouse, rat NXPH1
      QuantiFast Probe-based Assays in human, mouse, rat NXPH1

    Additional mRNA sequence: 

    AB047362.1 AB073665.1 AK091655.1 AK095624.1 AK296248.1 AK315141.1 BC047505.1 

    2 DOTS entries:

    DT.205841  DT.121099452 

    16 AceView cDNA sequences:

    AI199172 AA575925 NM_152745 AB047362 W01382 N62902 BX107562 AK091655 
    AK095624 BI669547 BI752460 AV707468 BC047505 T08230 AU252730 AA057092 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NXPH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGTTATAA
    NXPH1 Expression
    About this image


    NXPH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
     
     Neural Tube (Nervous System)
             Telencephalon
    NXPH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NXPH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487564
        Custom PCR Arrays for NXPH1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NXPH1
    OriGene qSTAR qPCR primer pairs in human, mouse for NXPH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXPH1
    QuantiTect SYBR Green Assays in human, mouse, rat NXPH1
    QuantiFast Probe-based Assays in human, mouse, rat NXPH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NXPH1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxph11 , 5 neurexophilin 11, 5 92.74(n)1
    99.63(a)1
      6 (4.38 cM)5
    182311  NM_008751.51  NP_032777.31 
     89484315 
    chicken
    (Gallus gallus)
    Aves NXPH11 neurexophilin 1 89.91(n)
    96.31(a)
      420582  XM_418683.4  XP_418683.2 
    lizard
    (Anolis carolinensis)
    Reptilia NXPH16
    neurexophilin 1
    95(a)
    1 ↔ 1
    6(23949714-24139290)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nxph11 neurexophilin 1 82.16(n)
    87.45(a)
      100145448  NM_001126902.1  NP_001120374.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148672 Transcribed sequence with weak similarity to protein more 80.09(n)    BM072575.1 


    ENSEMBL Gene Tree for NXPH1 (if available)
    TreeFam Gene Tree for NXPH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NXPH1 gene
    NXPH42  NXPH32  NXPH22  
    4 SIMAP similar genes for NXPH1 using alignment to 4 protein entries:     NXPH1_HUMAN (see all proteins):
    Nbla00697    NXPH2    NXPH3    NXPH4

    Find genes that share paralogs with NXPH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NXPH1 (see all 8076)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1905196201,2
    --8471649(+) AGTATG/TTTTTT 1 -- us2k10--------
    rs1819642201,2
    --8471714(+) CTTGGC/TATATT 1 -- us2k10--------
    rs1485287891,2
    C--8471733(+) AGCCGG/TATTCT 1 -- us2k10--------
    rs1862972461,2
    --8471743(+) TTTCTA/CATTTT 1 -- us2k10--------
    rs1169390781,2
    C,F--8471749(+) ATTTTC/TCCAAA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1898503381,2
    --8471762(+) TCAGAA/CAGAAG 1 -- us2k10--------
    rs77771031,2
    C,F,A--8471795(+) CTGGGA/CATCCA 1 -- us2k16Minor allele frequency- C:0.13NA CSA WA 246
    rs599411781,2
    C,F--8471816(+) GGCAAC/TATTTG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1827576271,2
    --8471963(+) AGATAC/TGGGTG 1 -- us2k10--------
    rs1878295711,2
    --8472016(+) AAGAAA/CATGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NXPH1 (8473585 - 8723585 bp, first 250kb of NXPH1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NXPH1 (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422215CNV Deletion17116639
    esv2032041CNV Deletion18987734
    esv2671627CNV Deletion23128226
    dgv1122e201CNV Deletion23290073
    esv2541093CNV Deletion19546169
    esv1995943CNV Deletion18987734
    esv2663047CNV Deletion23128226
    esv2733945CNV Deletion23290073
    esv2678359CNV Deletion23128226
    esv1006527CNV Deletion20482838

    Human Gene Mutation Database (HGMD): NXPH1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NXPH1
    DNA2.0 Custom Variant and Variant Library Synthesis for NXPH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604639    OMIM disorders: --


    Find genes that share disorders with NXPH1           About GenesLikeMe

    Genetic Association Database (GAD): NXPH1
    Human Genome Epidemiology (HuGE) Navigator: NXPH1 (5 documents)

    Export disorders for NXPH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NXPH1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with NXPH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PubMed id 9570794)1, 3, 9 Missler M. and Suedhof T.C. (J. Neurosci. 1998)
    2. Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. (PubMed id 20100581)1, 4 Shen L....Saykin A.J. (Neuroimage 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. Case-control genome-wide association study of attention-deficit/hyperactivity disorder. (PubMed id 20732627)1, 4 Neale B.M....Biederman J. (J Am Acad Child Adolesc Psychiatry 2010)
    6. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
    7. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. (PubMed id 18762592)1, 4 van den Oord E.J....Rujescu D. (Arch. Gen. Psychiatry 2008)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (Cancer Lett. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 30010 HGNC: 20693 AceView: NXPH1 Ensembl:ENSG00000122584 euGenes: HUgn30010
    ECgene: NXPH1 H-InvDB: NXPH1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NXPH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NXPH1 gene:
    Search GeneIP for patents involving NXPH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NXPH1 (Neurexophilin-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for NXPH1 (Neurexophilin-1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NXPH1   OriGene RNAi products in human, mouse, rat for NXPH1  
     OriGene qPCR primer pairs and template standards for NXPH1   OriGene Protein Over-expression Lysate for NXPH1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NXPH1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NXPH1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NXPH1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NXPH1   OriGene Custom Protein Services for NXPH1  

     
     
     Block miRNA regulation of human, mouse, rat NXPH1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NXPH1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NXPH1 Predesigned siRNA for gene silencing in human, mouse, rat NXPH1
     QuantiFast Probe-based Assays in human, mouse, rat NXPH1 QuantiTect SYBR Green Assays in human, mouse, rat NXPH1
     Custom PCR Arrays for NXPH1 Search Chromatin IP Primers for NXPH1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXPH1  Search GeneGlobe Interaction Network for NXPH1
     Regulatory tfbs in NXPH1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NXPH1 GenScript cDNA clones with any tag delivered in your preferred vector for NXPH1
     GenScript Custom Assay Services for NXPH1 GenScript Custom overexpressing Cell Line Services for NXPH1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NXPH1
     Proteins for NXPH1
     Cell Lysates for NXPH1
     cDNA Clones for NXPH1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NXPH1 antibodies
     NXPH1 proteins
     NXPH1 lysates
     Antibodies for NXPH1
     See all of Abcam's Antibodies, Kits and Proteins for NXPH1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NXPH1
     Antibodies for NXPH1
     ELISAs for NXPH1
     CLIAs for NXPH1



     Browse ESI BIO Cell Lines and PureStem Progenitors for NXPH1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH1
     SwitchGear 3'UTR luciferase reporter plasmids for NXPH1
     SwitchGear Promoter luciferase reporter plasmids for NXPH1
     ThermoFisher Antibody for NXPH1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NXPH1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NXPH1
     LSBio Antibodies in human, mouse, rat for NXPH1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NXPH1
      Search eBioscience for proteins for NXPH1
      Search eBioscience for elisas for NXPH1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NXPH1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4