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Aliases for NXPH1 Gene

Aliases for NXPH1 Gene

  • Neurexophilin 1 2 3
  • NPH1 3 4
  • Neurexophilin-1 3
  • Nbla00697 3

External Ids for NXPH1 Gene

Previous GeneCards Identifiers for NXPH1 Gene

  • GC07U990268
  • GC07P008117
  • GC07P008217
  • GC07P008246
  • GC07P008326

Summaries for NXPH1 Gene

Entrez Gene Summary for NXPH1 Gene

  • This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. [provided by RefSeq, Jul 2008]

GeneCards Summary for NXPH1 Gene

NXPH1 (Neurexophilin 1) is a Protein Coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is NXPH4.

UniProtKB/Swiss-Prot for NXPH1 Gene

  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Gene Wiki entry for NXPH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH1 Gene

Genomics for NXPH1 Gene

Regulatory Elements for NXPH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NXPH1 Gene

8,433,955 bp from pter
8,752,963 bp from pter
319,009 bases
Plus strand

Genomic View for NXPH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH1 Gene

Proteins for NXPH1 Gene

  • Protein details for NXPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8NB31

    Protein attributes for NXPH1 Gene

    271 amino acids
    Molecular mass:
    31082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH1 Gene

Proteomics data for NXPH1 Gene at MOPED

Post-translational modifications for NXPH1 Gene

  • Glycosylation at Asn23, Asn68, Asn93, Asn146, Asn156, and Asn162
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH1 Gene

Antibody Products

  • R&D Systems Antibodies for NXPH1 (Neurexophilin-1)

No data available for DME Specific Peptides for NXPH1 Gene

Domains for NXPH1 Gene

Protein Domains for NXPH1 Gene


Suggested Antigen Peptide Sequences for NXPH1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the neurexophilin family.
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH1: view

No data available for Gene Families for NXPH1 Gene

Function for NXPH1 Gene

Molecular function for NXPH1 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Gene Ontology (GO) - Molecular Function for NXPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with NXPH1: view

Phenotypes for NXPH1 Gene

genes like me logo Genes that share phenotypes with NXPH1: view

Animal Models for NXPH1 Gene

MGI Knock Outs for NXPH1:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXPH1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for NXPH1 Gene

Localization for NXPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH1 Gene


Subcellular locations from

Jensen Localization Image for NXPH1 Gene COMPARTMENTS Subcellular localization image for NXPH1 gene
Compartment Confidence
extracellular 3
cytosol 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NXPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH1: view

Pathways for NXPH1 Gene

SuperPathways for NXPH1 Gene

No Data Available

Interacting Proteins for NXPH1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000384551 P58417-NXPH1_HUMAN for NXPH1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NXPH1 Gene


No data available for Pathways by source for NXPH1 Gene

Transcripts for NXPH1 Gene

mRNA/cDNA for NXPH1 Gene

Unigene Clusters for NXPH1 Gene

Neurexophilin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXPH1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH1 Gene

No ASD Table

Relevant External Links for NXPH1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXPH1 Gene

mRNA expression in normal human tissues for NXPH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPH1 Gene

This gene is overexpressed in Adrenal Gland (7.2), Brain - Hypothalamus (6.2), Brain - Anterior cingulate cortex (BA24) (6.2), Brain - Amygdala (4.6), and Brain - Frontal Cortex (BA9) (4.2).

SOURCE GeneReport for Unigene cluster for NXPH1 Gene Hs.487564

genes like me logo Genes that share expressions with NXPH1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for NXPH1 Gene

Orthologs for NXPH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXPH1 35
  • 94.96 (n)
  • 99.26 (a)
NXPH1 36
  • 95 (a)
(Canis familiaris)
Mammalia NXPH1 35
  • 96.68 (n)
  • 99.63 (a)
NXPH1 36
  • 99 (a)
(Mus musculus)
Mammalia Nxph1 35
  • 92.74 (n)
  • 99.63 (a)
Nxph1 16
Nxph1 36
  • 100 (a)
(Pan troglodytes)
Mammalia NXPH1 35
  • 99.51 (n)
  • 100 (a)
NXPH1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nxph1 35
  • 92.62 (n)
  • 98.89 (a)
(Monodelphis domestica)
Mammalia NXPH1 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia NXPH1 36
  • 85 (a)
(Gallus gallus)
Aves NXPH1 35
  • 89.91 (n)
  • 96.31 (a)
NXPH1 36
  • 96 (a)
(Anolis carolinensis)
Reptilia NXPH1 36
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph1 35
  • 82.16 (n)
  • 87.45 (a)
(Danio rerio)
Actinopterygii Dr.14867 35
nxph1 35
  • 76.01 (n)
  • 87.45 (a)
nxph1 36
  • 88 (a)
Species with no ortholog for NXPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH1 Gene

Gene Tree for NXPH1 (if available)
Gene Tree for NXPH1 (if available)

Paralogs for NXPH1 Gene

Paralogs for NXPH1 Gene

(4) SIMAP similar genes for NXPH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NXPH1: view

Variants for NXPH1 Gene

Sequence variations from dbSNP and Humsavar for NXPH1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs338 -- 8,644,051(+) GTGTT(C/T)CACAG intron-variant
rs16449 -- 8,668,649(+) gcctg(-/AGTCTG)caggg intron-variant
rs726307 -- 8,689,624(+) GGGCA(G/T)GAGAA intron-variant
rs732234 -- 8,695,105(+) GATAT(G/T)ATTCC intron-variant
rs735032 -- 8,464,831(+) TAGCA(A/G)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXPH1 Gene

Variant ID Type Subtype PubMed ID
nsv887492 CNV Gain 21882294
nsv464305 CNV Gain 19166990
nsv464308 CNV Gain 19166990
nsv887494 CNV Loss 21882294
nsv887495 CNV Gain 21882294
nsv887496 CNV Gain 21882294
nsv830896 CNV Gain 17160897
nsv818477 CNV Loss 17921354
nsv830897 CNV Gain 17160897
nsv887497 CNV Gain 21882294
esv272001 CNV Insertion 20981092
esv2663047 CNV Deletion 23128226
nsv887498 CNV Gain 21882294
nsv519262 CNV Loss 19592680
esv2541093 CNV Deletion 19546169
esv1995943 CNV Deletion 18987734
esv3131 CNV Deletion 18987735
dgv1122e201 CNV Deletion 23290073
esv6164 CNV Loss 19470904
esv1006527 CNV Deletion 20482838
esv2671627 CNV Deletion 23128226
esv1763008 CNV Deletion 17803354
nsv518729 CNV Gain 19592680
nsv469922 CNV Loss 18288195
nsv464310 CNV Loss 19166990
esv2032041 CNV Deletion 18987734
esv2633635 CNV Deletion 19546169
esv2733945 CNV Deletion 23290073
esv2493792 CNV Deletion 19546169
esv2678359 CNV Deletion 23128226
nsv519648 CNV Loss 19592680
nsv520962 CNV Loss 19592680
esv2422215 CNV Deletion 17116639
esv2733946 CNV Deletion 23290073
nsv887499 CNV Loss 21882294
nsv819939 CNV Gain 19587683

Relevant External Links for NXPH1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPH1 Gene

Disorders for NXPH1 Gene

Relevant External Links for NXPH1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NXPH1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NXPH1 Gene

Publications for NXPH1 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M. … Suedhof T.C. (J. Neurosci. 1998) 2 3 23
  2. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 48
  3. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. (PMID: 18762592) van den Oord E.J. … Rujescu D. (Arch. Gen. Psychiatry 2008) 3 48
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M. … Nakagawara A. (Cancer Lett. 2003) 3 4

Products for NXPH1 Gene

Sources for NXPH1 Gene

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