Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NXPH1 Gene

Aliases for NXPH1 Gene

  • Neurexophilin 1 2 3 5
  • NPH1 3 4
  • Neurexophilin-1 3
  • Nbla00697 3

External Ids for NXPH1 Gene

Previous GeneCards Identifiers for NXPH1 Gene

  • GC07U990268
  • GC07P008117
  • GC07P008217
  • GC07P008246
  • GC07P008326

Summaries for NXPH1 Gene

Entrez Gene Summary for NXPH1 Gene

  • This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. [provided by RefSeq, Jul 2008]

GeneCards Summary for NXPH1 Gene

NXPH1 (Neurexophilin 1) is a Protein Coding gene. Diseases associated with NXPH1 include Paranoid Schizophrenia. GO annotations related to this gene include receptor binding. An important paralog of this gene is NXPH2.

UniProtKB/Swiss-Prot for NXPH1 Gene

  • May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Gene Wiki entry for NXPH1 Gene

Additional gene information for NXPH1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPH1 Gene

Genomics for NXPH1 Gene

Regulatory Elements for NXPH1 Gene

Enhancers for NXPH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H008389 0.9 Ensembl ENCODE 10.6 -43.9 -43910 1 PKNOX1 NRF1 ATF2 FOXK2 POLR2A IKZF1 SCRT2 NFYB TRIM28 NXPH1 GC07P008388
GH07H008442 0.9 FANTOM5 ENCODE 5.1 +9.0 9039 0 RAD51 SUZ12 ZNF143 USF2 MIER2 REST EZH2 NXPH1 GC07P008505
GH07H008739 0.3 FANTOM5 10.5 +305.2 305228 0 NXPH1 PIR39779 GC07M008865
GH07H008624 0.3 FANTOM5 3.2 +190.3 190296 0 NXPH1 LOC105375144 GC07M008552
GH07H008161 0.3 FANTOM5 2.3 -273.1 -273072 0 ENSG00000227719 NXPH1 GC07P008190
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NXPH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXPH1 Gene

Chromosome:
7
Start:
8,433,955 bp from pter
End:
8,752,963 bp from pter
Size:
319,009 bases
Orientation:
Plus strand

Genomic View for NXPH1 Gene

Genes around NXPH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPH1 Gene

Proteins for NXPH1 Gene

  • Protein details for NXPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58417-NXPH1_HUMAN
    Recommended name:
    Neurexophilin-1
    Protein Accession:
    P58417
    Secondary Accessions:
    • Q8NB31

    Protein attributes for NXPH1 Gene

    Size:
    271 amino acids
    Molecular mass:
    31082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXPH1 Gene

Post-translational modifications for NXPH1 Gene

  • Glycosylation at Asn23, posLast=6868, posLast=9393, posLast=146146, posLast=156156, and posLast=162162
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPH1 Gene

Antibody Products

  • R&D Systems Antibodies for NXPH1 (Neurexophilin-1)
  • Abcam antibodies for NXPH1

Protein Products

  • Abcam proteins for NXPH1

No data available for DME Specific Peptides for NXPH1 Gene

Domains & Families for NXPH1 Gene

Gene Families for NXPH1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NXPH1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NXPH1 Gene

Graphical View of Domain Structure for InterPro Entry

P58417

UniProtKB/Swiss-Prot:

NXPH1_HUMAN :
  • Belongs to the neurexophilin family.
Family:
  • Belongs to the neurexophilin family.
genes like me logo Genes that share domains with NXPH1: view

Function for NXPH1 Gene

Molecular function for NXPH1 Gene

UniProtKB/Swiss-Prot Function:
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

Phenotypes From GWAS Catalog for NXPH1 Gene

Gene Ontology (GO) - Molecular Function for NXPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with NXPH1: view
genes like me logo Genes that share phenotypes with NXPH1: view

Animal Models for NXPH1 Gene

MGI Knock Outs for NXPH1:

Animal Model Products

CRISPR Products

miRNA for NXPH1 Gene

miRTarBase miRNAs that target NXPH1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NXPH1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXPH1 Gene

Localization for NXPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPH1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPH1 gene
Compartment Confidence
extracellular 4
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NXPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPH1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NXPH1 Gene

Pathways & Interactions for NXPH1 Gene

SuperPathways for NXPH1 Gene

No Data Available

Interacting Proteins for NXPH1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000384551%0d%0a9606.ENSP00000385142%0d%0a
Selected Interacting proteins: ENSP00000384551 P58417-NXPH1_HUMAN for NXPH1 Gene via STRING IID

SIGNOR curated interactions for NXPH1 Gene

Activates:

Gene Ontology (GO) - Biological Process for NXPH1 Gene

None

No data available for Pathways by source for NXPH1 Gene

Drugs & Compounds for NXPH1 Gene

No Compound Related Data Available

Transcripts for NXPH1 Gene

mRNA/cDNA for NXPH1 Gene

Unigene Clusters for NXPH1 Gene

Neurexophilin 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NXPH1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NXPH1 Gene

No ASD Table

Relevant External Links for NXPH1 Gene

GeneLoc Exon Structure for
NXPH1
ECgene alternative splicing isoforms for
NXPH1

Expression for NXPH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NXPH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPH1 Gene

This gene is overexpressed in Adrenal Gland (x7.2), Brain - Hypothalamus (x6.2), Brain - Anterior cingulate cortex (BA24) (x6.2), Brain - Amygdala (x4.6), and Brain - Frontal Cortex (BA9) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of NXPH1 Gene:

NXPH1

SOURCE GeneReport for Unigene cluster for NXPH1 Gene:

Hs.487564

Evidence on tissue expression from TISSUES for NXPH1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with NXPH1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPH1 Gene

Orthologs for NXPH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXPH1 33 34
  • 99.51 (n)
oppossum
(Monodelphis domestica)
Mammalia NXPH1 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXPH1 33 34
  • 96.68 (n)
cow
(Bos Taurus)
Mammalia NXPH1 33 34
  • 94.96 (n)
mouse
(Mus musculus)
Mammalia Nxph1 33 16 34
  • 92.74 (n)
rat
(Rattus norvegicus)
Mammalia Nxph1 33
  • 92.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NXPH1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves NXPH1 33 34
  • 89.91 (n)
lizard
(Anolis carolinensis)
Reptilia NXPH1 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxph1 33
  • 82.16 (n)
zebrafish
(Danio rerio)
Actinopterygii nxph1 33 34
  • 76.01 (n)
Dr.14867 33
Species where no ortholog for NXPH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPH1 Gene

ENSEMBL:
Gene Tree for NXPH1 (if available)
TreeFam:
Gene Tree for NXPH1 (if available)

Paralogs for NXPH1 Gene

Paralogs for NXPH1 Gene

(4) SIMAP similar genes for NXPH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NXPH1: view

Variants for NXPH1 Gene

Sequence variations from dbSNP and Humsavar for NXPH1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000005918 -- 8,485,563(+) TCTCC(A/G)GGCCC intron-variant
rs1000030661 -- 8,528,707(+) ACTGC(A/G)CATAC intron-variant
rs1000041039 -- 8,732,808(+) TAGGA(C/T)ACAAC intron-variant
rs1000045808 -- 8,472,309(+) AAGGC(A/C)CTTCT intron-variant
rs1000057748 -- 8,723,438(+) TTGTC(A/C)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXPH1 Gene

Variant ID Type Subtype PubMed ID
dgv1075e201 CNV deletion 23290073
dgv11178n54 CNV gain 21841781
dgv11184n54 CNV gain 21841781
dgv1256e214 CNV gain 21293372
dgv6253n100 CNV gain 25217958
dgv6254n100 CNV loss 25217958
dgv6255n100 CNV loss 25217958
dgv6256n100 CNV gain 25217958
esv1006527 CNV deletion 20482838
esv1763008 CNV deletion 17803354
esv1995943 CNV deletion 18987734
esv2032041 CNV deletion 18987734
esv2422215 CNV deletion 17116639
esv2493792 CNV deletion 19546169
esv2541093 CNV deletion 19546169
esv2633635 CNV deletion 19546169
esv2663047 CNV deletion 23128226
esv2671627 CNV deletion 23128226
esv2678359 CNV deletion 23128226
esv2733945 CNV deletion 23290073
esv2733946 CNV deletion 23290073
esv2761144 CNV gain+loss 21179565
esv3131 CNV loss 18987735
esv3307727 CNV mobile element insertion 20981092
esv3339626 CNV insertion 20981092
esv3405546 CNV insertion 20981092
esv3541143 CNV deletion 23714750
esv3541144 CNV deletion 23714750
esv3571618 CNV loss 25503493
esv3612108 CNV loss 21293372
esv3612110 CNV loss 21293372
esv3612113 CNV loss 21293372
esv3612114 CNV loss 21293372
esv3612116 CNV loss 21293372
esv3891041 CNV loss 25118596
esv6164 CNV loss 19470904
nsv1019184 CNV gain 25217958
nsv1021226 CNV loss 25217958
nsv1022414 CNV gain 25217958
nsv1025549 CNV gain 25217958
nsv1026683 CNV loss 25217958
nsv1028240 CNV gain 25217958
nsv1030264 CNV loss 25217958
nsv1032652 CNV loss 25217958
nsv1074629 CNV deletion 25765185
nsv1124172 CNV deletion 24896259
nsv1140745 CNV deletion 24896259
nsv1147531 CNV deletion 26484159
nsv1148346 CNV deletion 26484159
nsv464305 CNV gain 19166990
nsv464308 CNV gain 19166990
nsv464310 CNV loss 19166990
nsv469922 CNV loss 18288195
nsv518729 CNV gain 19592680
nsv519262 CNV loss 19592680
nsv519648 CNV loss 19592680
nsv520962 CNV loss 19592680
nsv606054 CNV gain 21841781
nsv606087 CNV loss 21841781
nsv606088 CNV gain 21841781
nsv606089 CNV loss 21841781
nsv606092 CNV loss 21841781
nsv606093 CNV loss 21841781
nsv606094 CNV loss 21841781
nsv818477 CNV loss 17921354
nsv819939 CNV gain 19587683
nsv830896 CNV gain 17160897
nsv830897 CNV gain 17160897
nsv955975 CNV deletion 24416366

Variation tolerance for NXPH1 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPH1 Gene

Human Gene Mutation Database (HGMD)
NXPH1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXPH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPH1 Gene

Disorders for NXPH1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NXPH1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
paranoid schizophrenia
  • chronic paranoid schizophrenia
- elite association - COSMIC cancer census association via MalaCards
Search NXPH1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NXPH1

Genetic Association Database (GAD)
NXPH1
Human Genome Epidemiology (HuGE) Navigator
NXPH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXPH1
genes like me logo Genes that share disorders with NXPH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXPH1 Gene

Publications for NXPH1 Gene

  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PMID: 9570794) Missler M … Südhof TC (The Journal of neuroscience : the official journal of the Society for Neuroscience 1998) 2 3 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Case-control genome-wide association study of attention-deficit/hyperactivity disorder. (PMID: 20732627) Neale BM … IMAGE II Consortium Group (Journal of the American Academy of Child and Adolescent Psychiatry 2010) 3 45 60
  4. Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. (PMID: 20100581) Shen L … Alzheimer's Disease Neuroimaging Initiative (NeuroImage 2010) 3 45 60
  5. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 45 60

Products for NXPH1 Gene

Sources for NXPH1 Gene

Content
Loading form....