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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXPH1 Gene

protein-coding   GIFtS: 54
GCID: GC07P008440

neurexophilin 1

 Explore 4 diseases affiliated with
NXPH1 via our new
 Human Malady Compendium 
Biological research products
for NXPH1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neurexophilin 11 2
NPH12 3
Neurexophilin-11

External Ids:    HGNC: 206931   Entrez Gene: 300102   Ensembl: ENSG000001225847   OMIM: 6046395   UniProtKB: P584173   

Export aliases for NXPH1 gene to outside databases

Previous GC identifers: GC07U990268 GC07P008117 GC07P008217 GC07P008246 GC07P008326


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NXPH1:
This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a
highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This
protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites
and axons. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417
Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and
possibly other receptors (Potential)

Gene Wiki entry for NXPH1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NXPH1 gene promoter:
         Nkx3-1 v2   AREB6   NRSF form 1   Nkx3-1 v3   Nkx3-1 v1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NXPH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NXPH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p22

NXPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXPH1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P008440:  view genomic region     (about GC identifiers)

Start:
8,473,585 bp from pter      End:
8,792,593 bp from pter
Size:
319,009 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 8,522,178-8,840,927     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417 (See protein sequence)
Recommended Name: Neurexophilin-1 precursor  
Size: 271 amino acids; 31082 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q8NB31

Explore the universe of human proteins at neXtProt for NXPH1: NX_P58417

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P58417

  • NXPH1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689958.1  
    ENSEMBL proteins: 
     ENSP00000384551   ENSP00000404689   ENSP00000408216   ENSP00000391627  

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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NXPH1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    NXPH1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NXPH1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NXPH1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR010450 Neurexophilin
     IPR026845 NXPH/NXPE

    Graphical View of Domain Structure for InterPro Entry P58417

    ProtoNet protein and cluster: P58417

    1 Blocks protein family: IPB010450 Neurexophilin

    UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417
    Similarity: Belongs to the neurexophilin family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NXPH1_HUMAN, P58417
    Function: May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and
    possibly other receptors (Potential)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXPH1
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    hsa-miR-24-1* hsa-miR-15a hsa-miR-485-3p hsa-miR-346 hsa-miR-500a hsa-miR-24-2* hsa-miR-424 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidNXPH1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXPH1 (see all 7)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IEA--


    NXPH1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NXPH1:
     Increased G1 DNA content  Increased cell size 

    Animal Models:
         Mouse knock-out Nxph1tm1Sud for NXPH1
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nxph1):
     growth/size  mortality/aging  reproductive system 

    NXPH1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXPH1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for NXPH1 (P584173 ENSP000003845514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRXN1Q9ULB13, ENSP000003851424I2D: score=1 STRING: ENSP00000385142
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXPH1
    Search CenterWatch for drugs/clinical trials and news about NXPH1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NXPH1 gene: 
    NM_152745.2  

    Unigene Cluster for NXPH1:

    Neurexophilin 1
    Hs.487564  [show with all ESTs]
    Unigene Representative Sequence: NM_152745
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000405863(uc003srv.3 uc011jxh.2) ENST00000438764 ENST00000429542
    ENST00000497400 ENST00000417186

    miRNA
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    OriGene 3'-UTR Clone: NXPH1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXPH1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate NXPH1 (see all 25):
    hsa-miR-24-1* hsa-miR-15a hsa-miR-485-3p hsa-miR-346 hsa-miR-500a hsa-miR-24-2* hsa-miR-424 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidNXPH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXPH1 (see all 7)
    OriGene shRNA RFP: NXPH1
    OriGene siRNA: NXPH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXPH1
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPH1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPH1

    Additional cDNA sequence: 

    AB047362.1 AB073665.1 AK091655.1 AK095624.1 AK296248.1 AK315141.1 BC047505.1 

    2 DOTS entries:

    DT.205841  DT.121099452 

    16 AceView cDNA sequences:

    W01382 AI199172 NM_152745 AB047362 AA575925 BI752460 AK091655 BC047505 
    AK095624 BI669547 N62902 BX107562 AV707468 AU252730 T08230 AA057092 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXPH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGTTATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    NXPH1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerType1 Off Cone Bipolar CellsBipolar, Retina
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb

    See NXPH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXPH1

    SOURCE GeneReport for Unigene cluster: Hs.487564
        SABiosciences Custom PCR Arrays for NXPH1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NXPH1 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NXPH11 neurexophilin 1 89.91(n)
    96.31(a)
      420582  XM_418683.3  XP_418683.2 
    lizard
    (Anolis carolinensis)
    Reptilia NXPH16
    --
    92(a)
    1 ↔ 1
    6(24138472-24139290)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148672 Transcribed sequence with weak similarity to protein more 80.09(n)    BM072575.1 


    ENSEMBL Gene Tree for NXPH1 (if available)
    TreeFam Gene Tree for NXPH1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXPH1 gene
    NXPH42  NXPH32  NXPH22  
    4 SIMAP similar genes for NXPH1 using alignment to 3 protein entries:     NXPH1_HUMAN (see all proteins):
    Nbla00697    NXPH2    NXPH3    NXPH4

    NXPH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7208 NCBI SNPs in NXPH1 are shown (see all 7208    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1905196201,2
    --8471649(+) AGTATG/TTTTTT 1 -- us2k10--------
    rs1819642201,2
    --8471714(+) CTTGGC/TATATT 1 -- us2k10--------
    rs1485287891,2
    --8471733(+) AGCCGG/TATTCT 1 -- us2k10--------
    rs1862972461,2
    --8471743(+) TTTCTA/CATTTT 1 -- us2k10--------
    rs1169390781,2
    F,--8471749(+) ATTTTC/TCCAAA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1898503381,2
    --8471762(+) TCAGAA/CAGAAG 1 -- us2k10--------
    rs77771031,2
    C,F,A,--8471795(+) CTGGGA/CATCCA 1 -- us2k16Minor allele frequency- C:0.13NA CSA WA 246
    rs599411781,2
    C,F,--8471816(+) GGCAAC/TATTTG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1827576271,2
    --8471963(+) AGATAC/TGGGTG 1 -- us2k10--------
    rs1878295711,2
    --8472016(+) AAGAAA/CATGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NXPH1 (8473585 - 8723585 bp, first 250kb of NXPH1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for NXPH1
         3 CNVs: 99859 10175 5396
         10 Indels: 47401 47403 40949 99860 94367 62613 41838 28703 59423 81862
    Human Gene Mutation Database (HGMD): NXPH1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPH1
    DNA2.0 Custom Variant and Variant Library Synthesis for NXPH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NXPH1 for disorders           About GeneDecksing

    OMIM gene information: 604639    OMIM disorders: --

    4 diseases for NXPH1:    About MalaCards
    angelman syndrome    prostate cancer    neuroblastoma    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: NXPH1 (5 documents)

    Export disorders for NXPH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXPH1 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with NXPH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. (PubMed id 9570794)1, 3, 9 Missler M. and Suedhof T.C. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb. (PubMed id 12141453)1, 9 Clarris H.J....Key B. (2002)
    7. Genome-wide association study indicates variants assoc iated with insulin signaling and inflammation mediate lipoprotein responses to f enofibrate. (PubMed id 22890011)1 Frazier-Wood A.C....Arnett D.K. (2012)
    8. Neurexophilin 1 suppresses the proliferation of hemat opoietic progenitor cells. (PubMed id 21628410)1 Kinzfogl J....Broxmeyer H.E. (2011)
    9. Novel autosomal recessive nonsyndromic hearing impair ment locus DFNB90 maps to 7p22.1-p15.3. (PubMed id 21734401)1 Ali G....Leal S.M. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 30010 HGNC: 20693 AceView: NXPH1 Ensembl:ENSG00000122584 euGenes: HUgn30010
    ECgene: NXPH1 H-InvDB: NXPH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXPH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NXPH1 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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