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Aliases for NXPE4 Gene

Aliases for NXPE4 Gene

  • Neurexophilin And PC-Esterase Domain Family Member 4 2 3 5
  • Family With Sequence Similarity 55, Member D 2 3
  • Protein FAM55D 3 4
  • C11orf33 3 4
  • FAM55D 3 4
  • Neurexophilin And PC-Esterase Domain Family, Member 4 2
  • Chromosome 11 Open Reading Frame 33 2
  • NXPE Family Member 4 3

External Ids for NXPE4 Gene

Previous HGNC Symbols for NXPE4 Gene

  • C11orf33
  • FAM55D

Previous GeneCards Identifiers for NXPE4 Gene

  • GC11M114442

Summaries for NXPE4 Gene

GeneCards Summary for NXPE4 Gene

NXPE4 (Neurexophilin And PC-Esterase Domain Family Member 4) is a Protein Coding gene. An important paralog of this gene is NXPE2.

Additional gene information for NXPE4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE4 Gene

Genomics for NXPE4 Gene

Regulatory Elements for NXPE4 Gene

Enhancers for NXPE4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H114214 1.6 FANTOM5 ENCODE dbSUPER 11.4 +379.2 379215 3 PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ATF7 GTF2B NCOA1 RBM7 ZW10 NNMT NXPE4 NXPE1 TTC12 ENSG00000270179 ZBTB16 PIR38575 PIR57549
GH11H113872 1.1 ENCODE 9.8 +720.9 720897 4 PKNOX1 MLX ARNT ZFP64 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 RBM7 ENSG00000270179 ZW10 USP28 NXPE4 LRRC37A13P GC11M113865
GH11H115500 1.3 FANTOM5 ENCODE 4.5 -907.3 -907299 4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 YY1 ZNF121 GLIS2 ZNF143 NXPE4 CADM1 GC11P115411
GH11H115488 0.8 ENCODE 4.8 -893.2 -893185 1 ZBTB21 INSM2 SIN3A CEBPG HIC1 CTBP1 GATA3 ZNF366 FOS KLF8 NXPE4 CADM1 GC11P115411
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NXPE4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXPE4 Gene

Chromosome:
11
Start:
114,570,591 bp from pter
End:
114,595,840 bp from pter
Size:
25,250 bases
Orientation:
Minus strand

Genomic View for NXPE4 Gene

Genes around NXPE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE4 Gene

Proteins for NXPE4 Gene

  • Protein details for NXPE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWF7-NXPE4_HUMAN
    Recommended name:
    NXPE family member 4
    Protein Accession:
    Q6UWF7
    Secondary Accessions:
    • Q6QDB4
    • Q9NXP5

    Protein attributes for NXPE4 Gene

    Size:
    544 amino acids
    Molecular mass:
    62263 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90965.1; Type=Frameshift; Positions=427; Evidence={ECO:0000305};

    Alternative splice isoforms for NXPE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXPE4 Gene

Post-translational modifications for NXPE4 Gene

  • Glycosylation at posLast=2929, posLast=3838, posLast=4747, posLast=4848, Asn92, Asn160, and Asn210
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPE4 Gene

No data available for DME Specific Peptides for NXPE4 Gene

Domains & Families for NXPE4 Gene

Gene Families for NXPE4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NXPE4 Gene

Suggested Antigen Peptide Sequences for NXPE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWF7

UniProtKB/Swiss-Prot:

NXPE4_HUMAN :
  • Belongs to the NXPE family.
Family:
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE4: view

Function for NXPE4 Gene

Gene Ontology (GO) - Molecular Function for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NXPE4: view

Phenotypes for NXPE4 Gene

genes like me logo Genes that share phenotypes with NXPE4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NXPE4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NXPE4 Gene

Localization for NXPE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPE4 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with NXPE4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NXPE4 Gene

Pathways & Interactions for NXPE4 Gene

SuperPathways for NXPE4 Gene

No Data Available

Interacting Proteins for NXPE4 Gene

Gene Ontology (GO) - Biological Process for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NXPE4: view

No data available for Pathways by source and SIGNOR curated interactions for NXPE4 Gene

Drugs & Compounds for NXPE4 Gene

No Compound Related Data Available

Transcripts for NXPE4 Gene

mRNA/cDNA for NXPE4 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPE4 Gene

Neurexophilin and PC-esterase domain family, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NXPE4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2:

Relevant External Links for NXPE4 Gene

GeneLoc Exon Structure for
NXPE4
ECgene alternative splicing isoforms for
NXPE4

Expression for NXPE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NXPE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPE4 Gene

This gene is overexpressed in Colon - Transverse (x48.3).

Protein differential expression in normal tissues from HIPED for NXPE4 Gene

This gene is overexpressed in Salivary gland (42.3) and Testis (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXPE4 Gene



Protein tissue co-expression partners for NXPE4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NXPE4 Gene:

NXPE4

SOURCE GeneReport for Unigene cluster for NXPE4 Gene:

Hs.179100

Evidence on tissue expression from TISSUES for NXPE4 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with NXPE4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPE4 Gene

Orthologs for NXPE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXPE4 33 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia NXPE4 33 34
  • 84.66 (n)
cow
(Bos Taurus)
Mammalia NXPE4 33 34
  • 84.35 (n)
mouse
(Mus musculus)
Mammalia Nxpe4 33 16 34
  • 79.75 (n)
rat
(Rattus norvegicus)
Mammalia Fam55b 33
  • 78.79 (n)
oppossum
(Monodelphis domestica)
Mammalia NXPE4 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 59 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 54 (a)
ManyToMany
-- 34
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486856 33
  • 56.82 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-285b23.3 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
Species where no ortholog for NXPE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE4 Gene

ENSEMBL:
Gene Tree for NXPE4 (if available)
TreeFam:
Gene Tree for NXPE4 (if available)

Paralogs for NXPE4 Gene

Paralogs for NXPE4 Gene

(3) SIMAP similar genes for NXPE4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXPE4: view

Variants for NXPE4 Gene

Sequence variations from dbSNP and Humsavar for NXPE4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000121884 -- 114,573,969(+) AAAAC(A/G)AGTCT intron-variant
rs1000198194 -- 114,592,189(+) CAGAG(A/C)AATAA intron-variant
rs1000388872 -- 114,586,399(+) GGACC(C/G)CAACT intron-variant
rs1000461288 -- 114,590,472(+) TGAGA(G/T)AGATC intron-variant
rs1000502133 -- 114,586,508(+) CTTAC(A/G)AGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXPE4 Gene

Variant ID Type Subtype PubMed ID
esv2759865 CNV gain 17122850
esv3627794 CNV gain 21293372
nsv1053425 CNV loss 25217958
nsv472708 CNV novel sequence insertion 20440878
nsv832274 CNV gain 17160897
nsv975981 CNV duplication 23825009

Variation tolerance for NXPE4 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXPE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPE4 Gene

Disorders for NXPE4 Gene

Relevant External Links for NXPE4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXPE4

No disorders were found for NXPE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE4 Gene

Publications for NXPE4 Gene

  1. Novel eukaryotic enzymes modifying cell-surface biopolymers. (PMID: 20056006) Anantharaman V … Aravind L (Biology direct 2010) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. (PMID: 15375555) Solmi R … Strippoli P (International journal of oncology 2004) 3 4 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 60

Products for NXPE4 Gene

Sources for NXPE4 Gene

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