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Aliases for NXPE4 Gene

Aliases for NXPE4 Gene

  • Neurexophilin And PC-Esterase Domain Family, Member 4 2 3
  • Family With Sequence Similarity 55, Member D 2 3
  • Protein FAM55D 3 4
  • C11orf33 3 4
  • FAM55D 3 4
  • Chromosome 11 Open Reading Frame 33 2
  • NXPE Family Member 4 3

External Ids for NXPE4 Gene

Previous HGNC Symbols for NXPE4 Gene

  • C11orf33
  • FAM55D

Previous GeneCards Identifiers for NXPE4 Gene

  • GC11M114442

Summaries for NXPE4 Gene

GeneCards Summary for NXPE4 Gene

NXPE4 (Neurexophilin And PC-Esterase Domain Family, Member 4) is a Protein Coding gene. An important paralog of this gene is NXPE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE4 Gene

Genomics for NXPE4 Gene

Genomic Location for NXPE4 Gene

Start:
114,570,591 bp from pter
End:
114,595,762 bp from pter
Size:
25,172 bases
Orientation:
Minus strand

Genomic View for NXPE4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXPE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE4 Gene

No data available for Regulatory Elements for NXPE4 Gene

Proteins for NXPE4 Gene

  • Protein details for NXPE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWF7-NXPE4_HUMAN
    Recommended name:
    NXPE family member 4
    Protein Accession:
    Q6UWF7
    Secondary Accessions:
    • Q6QDB4
    • Q9NXP5

    Protein attributes for NXPE4 Gene

    Size:
    544 amino acids
    Molecular mass:
    62263 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90965.1; Type=Frameshift; Positions=427; Evidence={ECO:0000305};

    Alternative splice isoforms for NXPE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXPE4 Gene

Proteomics data for NXPE4 Gene at MOPED

Post-translational modifications for NXPE4 Gene

  • Glycosylation at Asn29, Asn38, Asn47, Asn48, Asn92, Asn160, and Asn210
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPE4 Gene

Domains for NXPE4 Gene

Protein Domains for NXPE4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6UWF7

UniProtKB/Swiss-Prot:

NXPE4_HUMAN :
  • Q6UWF7
Family:
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NXPE4 Gene

Function for NXPE4 Gene

Gene Ontology (GO) - Molecular Function for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NXPE4: view

Phenotypes for NXPE4 Gene

GenomeRNAi human phenotypes for NXPE4:
genes like me logo Genes that share phenotypes with NXPE4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NXPE4 Gene

Localization for NXPE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE4 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with NXPE4: view

No data available for Subcellular locations from COMPARTMENTS for NXPE4 Gene

Pathways for NXPE4 Gene

SuperPathways for NXPE4 Gene

No Data Available

Interacting Proteins for NXPE4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364627%0d%0a9606.ENSP00000309591%0d%0a
Selected Interacting proteins: ENSP00000364627 for NXPE4 Gene via STRING

Symbol External ID(s) Details
PRKACA

Gene Ontology (GO) - Biological Process for NXPE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NXPE4: view

No data available for Pathways by source for NXPE4 Gene

Transcripts for NXPE4 Gene

mRNA/cDNA for NXPE4 Gene

(9) Selected AceView cDNA sequences:
(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPE4 Gene

Neurexophilin and PC-esterase domain family, member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXPE4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NXPE4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2:

Relevant External Links for NXPE4 Gene

GeneLoc Exon Structure for
NXPE4
ECgene alternative splicing isoforms for
NXPE4

Expression for NXPE4 Gene

mRNA expression in normal human tissues for NXPE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPE4 Gene

This gene is overexpressed in Colon - Transverse (48.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NXPE4 Gene

SOURCE GeneReport for Unigene cluster for NXPE4 Gene Hs.179100

genes like me logo Genes that share expressions with NXPE4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NXPE4 Gene

Orthologs for NXPE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXPE4 35
  • 99.14 (n)
  • 99.26 (a)
NXPE4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NXPE4 35
  • 84.35 (n)
  • 78.59 (a)
NXPE4 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXPE4 35
  • 84.66 (n)
  • 79.78 (a)
NXPE4 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nxpe4 35
  • 79.75 (n)
  • 73.15 (a)
Nxpe4 16
Nxpe4 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NXPE4 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fam55b 35
  • 78.79 (n)
  • 72.73 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486856 35
  • 56.82 (n)
  • 49.25 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-285b23.3 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
Species with no ortholog for NXPE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE4 Gene

ENSEMBL:
Gene Tree for NXPE4 (if available)
TreeFam:
Gene Tree for NXPE4 (if available)

Paralogs for NXPE4 Gene

Paralogs for NXPE4 Gene

Selected SIMAP similar genes for NXPE4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXPE4: view

Variants for NXPE4 Gene

Sequence variations from dbSNP and Humsavar for NXPE4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs474427 -- 114,572,851(+) acaag(A/C)agctc intron-variant
rs476729 -- 114,581,428(-) ACCCA(C/G)TTCTT intron-variant
rs477491 -- 114,581,388(-) ACTCC(C/T)ATCAC intron-variant
rs481080 -- 114,571,543(-) TCTTC(C/T)ATCTT intron-variant
rs487707 -- 114,579,986(+) AGGAA(A/G)GATAA intron-variant, downstream-variant-500B

Relevant External Links for NXPE4 Gene

HapMap Linkage Disequilibrium report
NXPE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NXPE4 Gene

Disorders for NXPE4 Gene

No disorders were found for NXPE4 Gene.

No data available for UniProtKB/Swiss-Prot for NXPE4 Gene

Publications for NXPE4 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. (PMID: 15375555) Solmi R. … Strippoli P. (Int. J. Oncol. 2004) 3 4
  4. Novel eukaryotic enzymes modifying cell-surface biopolymers. (PMID: 20056006) Anantharaman V. … Aravind L. (Biol. Direct 2010) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for NXPE4 Gene

Sources for NXPE4 Gene

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