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Aliases for NXPE4 Gene

Aliases for NXPE4 Gene

  • Neurexophilin And PC-Esterase Domain Family Member 4 2 3 5
  • Neurexophilin And PC-Esterase Domain Family, Member 4 2 3
  • Family With Sequence Similarity 55, Member D 2 3
  • Protein FAM55D 3 4
  • C11orf33 3 4
  • FAM55D 3 4
  • Chromosome 11 Open Reading Frame 33 2

External Ids for NXPE4 Gene

Previous HGNC Symbols for NXPE4 Gene

  • C11orf33
  • FAM55D

Previous GeneCards Identifiers for NXPE4 Gene

  • GC11M114442

Summaries for NXPE4 Gene

GeneCards Summary for NXPE4 Gene

NXPE4 (Neurexophilin And PC-Esterase Domain Family Member 4) is a Protein Coding gene. An important paralog of this gene is NXPE1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE4 Gene

Genomics for NXPE4 Gene

Genomic Location for NXPE4 Gene

114,570,591 bp from pter
114,595,840 bp from pter
25,250 bases
Minus strand

Genomic View for NXPE4 Gene

Genes around NXPE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE4 Gene

No data available for Regulatory Elements for NXPE4 Gene

Proteins for NXPE4 Gene

  • Protein details for NXPE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NXPE family member 4
    Protein Accession:
    Secondary Accessions:
    • Q6QDB4
    • Q9NXP5

    Protein attributes for NXPE4 Gene

    544 amino acids
    Molecular mass:
    62263 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA90965.1; Type=Frameshift; Positions=427; Evidence={ECO:0000305};

    Alternative splice isoforms for NXPE4 Gene


neXtProt entry for NXPE4 Gene

Proteomics data for NXPE4 Gene at MOPED

Post-translational modifications for NXPE4 Gene

  • Glycosylation at Asn 29, Asn 38, Asn 47, Asn 48, Asn 92, Asn 160, and Asn 210
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPE4 Gene

Domains & Families for NXPE4 Gene

Protein Domains for NXPE4 Gene


Suggested Antigen Peptide Sequences for NXPE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NXPE family.
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE4: view

No data available for Gene Families for NXPE4 Gene

Function for NXPE4 Gene

Phenotypes for NXPE4 Gene

genes like me logo Genes that share phenotypes with NXPE4: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NXPE4 Gene

Localization for NXPE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE4 Gene


Subcellular locations from

Jensen Localization Image for NXPE4 Gene COMPARTMENTS Subcellular localization image for NXPE4 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NXPE4 Gene

Pathways & Interactions for NXPE4 Gene

SuperPathways for NXPE4 Gene

No Data Available

Interacting Proteins for NXPE4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000364627 for NXPE4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NXPE4 Gene


No data available for Pathways by source and SIGNOR curated interactions for NXPE4 Gene

Drugs & Compounds for NXPE4 Gene

No Compound Related Data Available

Transcripts for NXPE4 Gene

mRNA/cDNA for NXPE4 Gene

(6) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPE4 Gene

Neurexophilin and PC-esterase domain family, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -

Relevant External Links for NXPE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXPE4 Gene

mRNA expression in normal human tissues for NXPE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPE4 Gene

This gene is overexpressed in Colon - Transverse (x48.3).

Protein differential expression in normal tissues from HIPED for NXPE4 Gene

This gene is overexpressed in Salivary gland (42.3) and Testis (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXPE4 Gene

SOURCE GeneReport for Unigene cluster for NXPE4 Gene Hs.179100

genes like me logo Genes that share expression patterns with NXPE4: view

Protein tissue co-expression partners for NXPE4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NXPE4 Gene

Orthologs for NXPE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXPE4 35
  • 84.35 (n)
  • 78.59 (a)
NXPE4 36
  • 77 (a)
(Canis familiaris)
Mammalia NXPE4 35
  • 84.66 (n)
  • 79.78 (a)
NXPE4 36
  • 79 (a)
(Mus musculus)
Mammalia Nxpe4 35
  • 79.75 (n)
  • 73.15 (a)
Nxpe4 16
Nxpe4 36
  • 73 (a)
(Pan troglodytes)
Mammalia NXPE4 35
  • 99.14 (n)
  • 99.26 (a)
NXPE4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fam55b 35
  • 78.79 (n)
  • 72.73 (a)
(Monodelphis domestica)
Mammalia NXPE4 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
-- 36
  • 51 (a)
-- 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
-- 36
  • 55 (a)
-- 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486856 35
  • 56.82 (n)
  • 49.25 (a)
(Danio rerio)
Actinopterygii si:dkey-285b23.3 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
-- 36
  • 25 (a)
-- 36
  • 20 (a)
-- 36
  • 22 (a)
-- 36
  • 22 (a)
-- 36
  • 22 (a)
-- 36
  • 22 (a)
-- 36
  • 23 (a)
-- 36
  • 21 (a)
Species with no ortholog for NXPE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE4 Gene

Gene Tree for NXPE4 (if available)
Gene Tree for NXPE4 (if available)

Paralogs for NXPE4 Gene

Paralogs for NXPE4 Gene

(3) SIMAP similar genes for NXPE4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXPE4: view

Variants for NXPE4 Gene

Sequence variations from dbSNP and Humsavar for NXPE4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs550897 - 114,571,381(-) AAAAA(C/T)ATTGT reference, missense
rs10891705 - 114,571,221(+) TGAGG(A/G)CCCTT reference, missense
rs474427 -- 114,572,851(+) acaag(A/C)agctc intron-variant
rs476729 -- 114,581,428(-) ACCCA(C/G)TTCTT intron-variant, utr-variant-3-prime
rs477491 -- 114,581,388(-) ACTCC(C/T)ATCAC intron-variant, utr-variant-3-prime

Variation tolerance for NXPE4 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPE4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NXPE4 Gene

Disorders for NXPE4 Gene

Relevant External Links for NXPE4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NXPE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE4 Gene

Publications for NXPE4 Gene

  1. Novel eukaryotic enzymes modifying cell-surface biopolymers. (PMID: 20056006) Anantharaman V. … Aravind L. (Biol. Direct 2010) 2 3 67
  2. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  3. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). (PMID: 19199708) Gonzalez-Begne M. … Yates J.R. (J. Proteome Res. 2009) 3

Products for NXPE4 Gene

Sources for NXPE4 Gene

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