NXPE4 Gene
protein-coding GIFtS: 37
GCID: GC11M114442
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neurexophilin and PC-esterase domain family, member 4(Previous names: chromosome 11 open reading frame 33, family with sequence...)
(Previous symbols: C11orf33, FAM55D)
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Aliases
for NXPE4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neurexophilin And PC-Esterase Domain Family, Member 41 2 | | Protein FAM55D2 3 | | C11orf331 2 3 | | FLJ201271 | | FAM55D1 2 3 | | Chromosome 11 Open Reading Frame 331 | | Family With Sequence Similarity 55, Member D1 2 | | NXPE Family Member 42 |
Export aliases for NXPE4 gene to outside databases |
Summaries
for NXPE4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NXPE4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NXPE4
Other transcription factors
Search SABiosciences Chromatin IP Primers for NXPE4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPE4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.2 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23.3NXPE4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M114442: view genomic region
(about GC identifiers)
Start:
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114,441,313 bp from pter |
End:
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114,466,484 bp from pter |
Size:
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25,172 bases |
Orientation:
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minus strand |
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Proteins
for NXPE4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NXPE4_HUMAN, Q6UWF7 (See
protein sequence)Recommended Name: NXPE family member 4 precursor Size: 544 amino acids; 62263 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=BAA90965.1; Type=Frameshift; Positions=427;
Secondary accessions: Q6QDB4 Q9NXP5Alternative splicing: 2 isoforms: Q6UWF7-1 Q6UWF7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NXPE4: NX_Q6UWF7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UWF7
NXPE4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001071107.1 NP_060148.2
ENSEMBL proteins: ENSP00000401503 ENSP00000364627
Human Recombinant Protein Products for NXPE4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
NXPE4 for ontologies About GeneDecksing
NXPE4 Antibody Products:
Assay Products for NXPE4: |
Protein
Domains /
Families
for NXPE4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NXPE4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UWF7ProtoNet protein and cluster: Q6UWF7 UniProtKB/Swiss-Prot: NXPE4_HUMAN, Q6UWF7Similarity: Belongs to the NXPE family |
Function
for NXPE4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for NXPE4:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for NXPE4 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPE4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NXPE4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPE4 |
|
Pathways & Interactions
for NXPE4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXPE4
|
Drugs & Compounds
for NXPE4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NXPE4
Search CenterWatch for drugs/clinical trials and news about NXPE4
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Transcripts
for NXPE4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NXPE4 gene (2 alternative transcripts): NM_001077639.1 NM_017678.2 Unigene Cluster for NXPE4: Neurexophilin and PC-esterase domain family, member 4 Hs.179100 [show with all ESTs]Unigene Representative Sequence: NM_0010776392 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000424261(uc001ppd.3) ENST00000375478(uc001ppc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE4 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for NXPE4 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPE4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NXPE4 |
Additional cDNA sequence: AK000134.1 AK225236.1 AY358805.1 AY547307.1 2 DOTS entries: DT.40118157 DT.99953479 9 AceView cDNA sequences: AI581835 BX090642 AY547307 AK000134 NM_017678 AY358805 AI833131 BG201797 BG199761
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for NXPE4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
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| SP1: | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NXPE4
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Expression
for NXPE4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See NXPE4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NXPE4
SOURCE GeneReport for Unigene cluster: Hs.179100
SABiosciences Custom PCR Arrays for NXPE4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXPE4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NXPE4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPE4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPE4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPE4 |
Orthologs
for NXPE4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NXPE4 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for NXPE4 (if available)
TreeFam Gene Tree for NXPE4 (if available) |
Paralogs
for NXPE4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NXPE4 gene
- NXPE22 NXPE12 NXPE32
3 SIMAP similar genes for NXPE4 using alignment to 1 protein entry: NXPE4_HUMAN:NXPE1 NXPE2 NXPE3
NXPE4 for paralogs About GeneDecksing
|
Genomic Variants
for NXPE4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NXPE4 (114441313 - 114466484 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NXPE4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPE4 |
|
Disorders
/ Diseases
for NXPE4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NXPE4 for disorders About GeneDecksing
1  disease for NXPE4: About MalaCardscolon cancer
Export disorders for NXPE4 gene to outside databases
|
Publications
for NXPE4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NXPE4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NXPE4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel eukaryotic enzymes modifying cell-surface biopo lymers. (PubMed id 20056006)1, 3 Anantharaman V. and Aravind L. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. (PubMed id 15375555)1, 2 Solmi R.... Strippoli P. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
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External Searches for NXPE4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NXPE4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NXPE4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NXPE4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NXPE4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NXPE4 gene:
Search GeneIP for patents involving NXPE4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NXPE4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NXPE4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXPE4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXPE4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NXPE4 | | OriGene 3'-UTR Clone for NXPE4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NXPE4 | | OriGene Custom Protein Services for NXPE4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NXPE4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPE4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPE4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXPE4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPE4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPE4 |
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 |  |  |  | |
| | | | Search Tocris compounds for NXPE4 |
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 | | | NXPE4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPE4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NXPE4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NXPE4 |
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