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Aliases for NXPE3 Gene

Aliases for NXPE3 Gene

  • Neurexophilin And PC-Esterase Domain Family Member 3 2 3 5
  • Neurexophilin And PC-Esterase Domain Family, Member 3 2 3
  • Family With Sequence Similarity 55, Member C 2 3
  • Protein FAM55C 3 4
  • FAM55C 3 4
  • MSTP115 3
  • MST115 3

External Ids for NXPE3 Gene

Previous HGNC Symbols for NXPE3 Gene

  • FAM55C

Previous GeneCards Identifiers for NXPE3 Gene

  • GC03P101499

Summaries for NXPE3 Gene

GeneCards Summary for NXPE3 Gene

NXPE3 (Neurexophilin And PC-Esterase Domain Family Member 3) is a Protein Coding gene. An important paralog of this gene is NXPE1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE3 Gene

Genomics for NXPE3 Gene

Regulatory Elements for NXPE3 Gene

Enhancers for NXPE3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NXPE3 on UCSC Golden Path with GeneCards custom track

Promoters for NXPE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NXPE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXPE3 Gene

101,779,185 bp from pter
101,828,231 bp from pter
49,047 bases
Plus strand

Genomic View for NXPE3 Gene

Genes around NXPE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE3 Gene

Proteins for NXPE3 Gene

  • Protein details for NXPE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NXPE family member 3
    Protein Accession:
    Secondary Accessions:
    • A8K0X4
    • D3DN53
    • Q7Z2S8

    Protein attributes for NXPE3 Gene

    559 amino acids
    Molecular mass:
    63800 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ13637.1; Type=Frameshift; Positions=345; Evidence={ECO:0000305};

neXtProt entry for NXPE3 Gene

Proteomics data for NXPE3 Gene at MOPED

Post-translational modifications for NXPE3 Gene

  • Glycosylation at Asn 237, Asn 292, and Asn 346
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NXPE3 Gene

Domains & Families for NXPE3 Gene

Protein Domains for NXPE3 Gene


Suggested Antigen Peptide Sequences for NXPE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NXPE family.
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE3: view

No data available for Gene Families for NXPE3 Gene

Function for NXPE3 Gene

genes like me logo Genes that share phenotypes with NXPE3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPE3 Gene

Localization for NXPE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE3 Gene


Subcellular locations from

Jensen Localization Image for NXPE3 Gene COMPARTMENTS Subcellular localization image for NXPE3 gene
Compartment Confidence
extracellular 4
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NXPE3 Gene

Pathways & Interactions for NXPE3 Gene

SuperPathways for NXPE3 Gene

No Data Available

Interacting Proteins for NXPE3 Gene

Gene Ontology (GO) - Biological Process for NXPE3 Gene


No data available for Pathways by source and SIGNOR curated interactions for NXPE3 Gene

Drugs & Compounds for NXPE3 Gene

No Compound Related Data Available

Transcripts for NXPE3 Gene

Unigene Clusters for NXPE3 Gene

Neurexophilin and PC-esterase domain family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE3 Gene

No ASD Table

Relevant External Links for NXPE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXPE3 Gene

mRNA expression in normal human tissues for NXPE3 Gene

mRNA differential expression in normal tissues according to GTEx for NXPE3 Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for NXPE3 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NXPE3 Gene

SOURCE GeneReport for Unigene cluster for NXPE3 Gene Hs.595933

genes like me logo Genes that share expression patterns with NXPE3: view

Protein tissue co-expression partners for NXPE3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NXPE3 Gene

Orthologs for NXPE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXPE3 35
  • 90.52 (n)
  • 92.84 (a)
NXPE3 36
  • 93 (a)
(Canis familiaris)
Mammalia NXPE3 35
  • 92.31 (n)
  • 93.56 (a)
NXPE3 36
  • 94 (a)
(Mus musculus)
Mammalia Nxpe3 35
  • 85.09 (n)
  • 88.55 (a)
Nxpe3 16
Nxpe3 36
  • 89 (a)
(Pan troglodytes)
Mammalia NXPE3 35
  • 99.46 (n)
  • 99.64 (a)
NXPE3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nxpe3 35
  • 86.05 (n)
  • 88.55 (a)
(Monodelphis domestica)
Mammalia NXPE3 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia NXPE3 36
  • 78 (a)
(Gallus gallus)
Aves NXPE3 35
  • 69.35 (n)
  • 68.82 (a)
NXPE3 36
  • 68 (a)
(Anolis carolinensis)
Reptilia NXPE3 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nxpe3 35
  • 61.98 (n)
  • 62.96 (a)
(Danio rerio)
Actinopterygii nxpe3 35
  • 57.91 (n)
  • 54.38 (a)
nxpe3 36
  • 49 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12254 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
-- 36
  • 27 (a)
-- 36
  • 24 (a)
-- 36
  • 24 (a)
-- 36
  • 24 (a)
-- 36
  • 24 (a)
-- 36
  • 22 (a)
-- 36
  • 18 (a)
-- 36
  • 22 (a)
Species with no ortholog for NXPE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE3 Gene

Gene Tree for NXPE3 (if available)
Gene Tree for NXPE3 (if available)

Paralogs for NXPE3 Gene

Paralogs for NXPE3 Gene

(3) SIMAP similar genes for NXPE3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NXPE3: view

Variants for NXPE3 Gene

Sequence variations from dbSNP and Humsavar for NXPE3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3796277 - 101,821,794(-) GGATG(A/G)TGTCC reference, missense
rs771326 -- 101,815,981(-) GTCTC(A/G)CTCTG intron-variant
rs771327 -- 101,815,656(-) AAACT(C/T)CTGAT intron-variant
rs797777 -- 101,809,013(+) TCACA(C/G)ACTCG intron-variant
rs2290859 -- 101,806,781(-) ATTCT(A/G)GTTTG intron-variant

Variation tolerance for NXPE3 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NXPE3 Gene

Disorders for NXPE3 Gene

Relevant External Links for NXPE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NXPE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE3 Gene

Publications for NXPE3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for NXPE3 Gene

Sources for NXPE3 Gene