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Aliases for NXPE3 Gene

Aliases for NXPE3 Gene

  • Neurexophilin And PC-Esterase Domain Family Member 3 2 3 5
  • Family With Sequence Similarity 55, Member C 2 3
  • FAM55C 3 4
  • Neurexophilin And PC-Esterase Domain Family, Member 3 2
  • NXPE Family Member 3 3
  • Protein FAM55C 4
  • MSTP115 3
  • MST115 3

External Ids for NXPE3 Gene

Previous HGNC Symbols for NXPE3 Gene

  • FAM55C

Previous GeneCards Identifiers for NXPE3 Gene

  • GC03P101499

Summaries for NXPE3 Gene

Entrez Gene Summary for NXPE3 Gene

  • This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for NXPE3 Gene

NXPE3 (Neurexophilin And PC-Esterase Domain Family Member 3) is a Protein Coding gene. An important paralog of this gene is NXPE4.

Additional gene information for NXPE3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE3 Gene

Genomics for NXPE3 Gene

GeneHancer (GH) Regulatory Elements for NXPE3 Gene

Promoters and enhancers for NXPE3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I101778 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 577.2 +0.8 841 3.4 HDGF PKNOX1 ATF1 ARID4B SIN3A ZBTB7B ZNF48 GLIS2 ZNF207 ZNF143 NXPE3 CEP97 RPL24 SENP7 ENSG00000249474
GH03I101723 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.5 -53.9 -53891 3 PKNOX1 ATF1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 NCOA2 ETS1 CEP97 ZBTB11-AS1 NXPE3 ZNF90P1
GH03I101825 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.1 +48.9 48903 5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 IRF4 YY1 NFKBIZ GC03P101828 NXPE3 ABI3BP ZBTB11
GH03I101674 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 -102.5 -102465 3.7 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 E2F8 ZBTB11 ZBTB11-AS1 NXPE3 SENP7 CEP97
GH03I101720 Enhancer 1 Ensembl ENCODE 29.6 -57.4 -57365 2.4 RB1 IRF4 NCOA2 ZNF143 ETV6 BCLAF1 IKZF2 RUNX3 SMARCA5 ELF1 GC03P101720 GC03P101721 NXPE3 ZBTB11 ZBTB11-AS1 RPL24 CEP97
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NXPE3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NXPE3 Gene

Genomic Locations for NXPE3 Gene
49,047 bases
Plus strand

Genomic View for NXPE3 Gene

Genes around NXPE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE3 Gene

Proteins for NXPE3 Gene

  • Protein details for NXPE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NXPE family member 3
    Protein Accession:
    Secondary Accessions:
    • A8K0X4
    • D3DN53
    • Q7Z2S8

    Protein attributes for NXPE3 Gene

    559 amino acids
    Molecular mass:
    63800 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ13637.1; Type=Frameshift; Positions=345; Evidence={ECO:0000305};

neXtProt entry for NXPE3 Gene

Post-translational modifications for NXPE3 Gene

  • Glycosylation at Asn237, Asn292, and isoforms=346

No data available for DME Specific Peptides for NXPE3 Gene

Domains & Families for NXPE3 Gene

Gene Families for NXPE3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for NXPE3 Gene

Suggested Antigen Peptide Sequences for NXPE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NXPE family.
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE3: view

Function for NXPE3 Gene

genes like me logo Genes that share phenotypes with NXPE3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPE3 Gene

Localization for NXPE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPE3 gene
Compartment Confidence
extracellular 4
nucleus 2
golgi apparatus 2
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NXPE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPE3: view

Pathways & Interactions for NXPE3 Gene

SuperPathways for NXPE3 Gene

No Data Available

Interacting Proteins for NXPE3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000273347 Q969Y0-NXPE3_HUMAN for NXPE3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NXPE3 Gene


No data available for Pathways by source and SIGNOR curated interactions for NXPE3 Gene

Drugs & Compounds for NXPE3 Gene

No Compound Related Data Available

Transcripts for NXPE3 Gene

Unigene Clusters for NXPE3 Gene

Neurexophilin and PC-esterase domain family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE3 Gene

No ASD Table

Relevant External Links for NXPE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXPE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NXPE3 Gene

mRNA differential expression in normal tissues according to GTEx for NXPE3 Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for NXPE3 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NXPE3 Gene

Protein tissue co-expression partners for NXPE3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NXPE3 Gene:


SOURCE GeneReport for Unigene cluster for NXPE3 Gene:


Evidence on tissue expression from TISSUES for NXPE3 Gene

  • Nervous system(4.6)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with NXPE3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NXPE3 Gene

Orthologs for NXPE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NXPE3 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia NXPE3 33 34
  • 92.31 (n)
(Bos Taurus)
Mammalia NXPE3 33 34
  • 90.52 (n)
(Rattus norvegicus)
Mammalia Nxpe3 33
  • 86.05 (n)
(Mus musculus)
Mammalia Nxpe3 33 16 34
  • 85.09 (n)
(Monodelphis domestica)
Mammalia NXPE3 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia NXPE3 34
  • 78 (a)
(Gallus gallus)
Aves NXPE3 33 34
  • 69.35 (n)
(Anolis carolinensis)
Reptilia NXPE3 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nxpe3 33
  • 61.98 (n)
(Danio rerio)
Actinopterygii nxpe3 33 34
  • 57.91 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12254 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
-- 34
  • 27 (a)
-- 34
  • 24 (a)
-- 34
  • 24 (a)
-- 34
  • 24 (a)
-- 34
  • 24 (a)
-- 34
  • 22 (a)
-- 34
  • 22 (a)
-- 34
  • 18 (a)
Species where no ortholog for NXPE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE3 Gene

Gene Tree for NXPE3 (if available)
Gene Tree for NXPE3 (if available)

Paralogs for NXPE3 Gene

Paralogs for NXPE3 Gene

(3) SIMAP similar genes for NXPE3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NXPE3: view

Variants for NXPE3 Gene

Sequence variations from dbSNP and Humsavar for NXPE3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs140150886 benign, Abnormality of neuronal migration 101,816,828(+) G/C coding_sequence_variant, missense_variant
rs863223380 benign, Abnormality of neuronal migration 101,801,593(+) TCAAGCTG/ coding_sequence_variant, frameshift
rs863223381 benign, Abnormality of neuronal migration 101,801,603(+) GG/G coding_sequence_variant, frameshift
rs1000049659 -- 101,800,571(+) C/T intron_variant
rs1000101115 -- 101,779,402(+) C/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NXPE3 Gene

Variant ID Type Subtype PubMed ID
esv2666056 CNV deletion 23128226
esv3597196 CNV loss 21293372
esv3597197 CNV loss 21293372
nsv953238 CNV duplication 24416366

Variation tolerance for NXPE3 Gene

Residual Variation Intolerance Score: 13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NXPE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPE3 Gene

Disorders for NXPE3 Gene

Additional Disease Information for NXPE3

No disorders were found for NXPE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE3 Gene

Publications for NXPE3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Genome-wide DNA methylation analysis in hepatocellular carcinoma. (PMID: 26883180) Yamada N … Itoh Y (Oncology reports 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for NXPE3 Gene

Sources for NXPE3 Gene

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