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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXPE3 Gene

protein-coding   GIFtS: 35
GCID: GC03P101499

Neurexophilin And PC-Esterase Domain Family, Member 3

(Previous names: family with sequence similarity 55, member C)
(Previous symbol: FAM55C)
  Search for NXPE3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurexophilin And PC-Esterase Domain Family, Member 31 2
FAM55C1 2 3
Family With Sequence Similarity 55, Member C1 2
Protein FAM55C2 3
MST1152
NXPE Family Member 32

External Ids:    HGNC: 282381   Entrez Gene: 917752   Ensembl: ENSG000001448157   UniProtKB: Q969Y03   

Export aliases for NXPE3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NXPE3 Gene: 
NXPE3 (neurexophilin and PC-esterase domain family, member 3) is a protein-coding gene. An important paralog of this gene is NXPE2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NXPE3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXPE3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NXPE3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.3   Ensembl cytogenetic band:  3q12.3   HGNC cytogenetic band: 3q12.3

NXPE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXPE3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P101499:  view genomic region     (about GC identifiers)

Start:
101,498,029 bp from pter      End:
101,547,075 bp from pter
Size:
49,047 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NXPE3_HUMAN, Q969Y0 (See protein sequence)
Recommended Name: NXPE family member 3 precursor  
Size: 559 amino acids; 63800 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAQ13637.1; Type=Frameshift; Positions=345;
Secondary accessions: A8K0X4 D3DN53 Q7Z2S8

Explore the universe of human proteins at neXtProt for NXPE3: NX_Q969Y0

Explore proteomics data for NXPE3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969Y0

  • NXPE3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NXPE3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001127928.1  NP_659474.1  

    ENSEMBL proteins: 
     ENSP00000418381   ENSP00000273347   ENSP00000419667   ENSP00000417485   ENSP00000418369  
     ENSP00000396421  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    NXPE3 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR026845 NXPH/NXPE

    Graphical View of Domain Structure for InterPro Entry Q969Y0

    ProtoNet protein and cluster: Q969Y0

    UniProtKB/Swiss-Prot: NXPE3_HUMAN, Q969Y0
    Similarity: Belongs to the NXPE family


    NXPE3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for NXPE3:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NXPE3 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPE3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXPE3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXPE3

    Search CenterWatch for drugs/clinical trials and news about NXPE3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NXPE3 gene (2 alternative transcripts): 
    NM_001134456.1  NM_145037.2  

    Unigene Cluster for NXPE3:

    Neurexophilin and PC-esterase domain family, member 3
    Hs.595933  [show with all ESTs]
    Unigene Representative Sequence: NM_001134456
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495842 ENST00000273347 ENST00000474165 ENST00000491511 ENST00000487830
    ENST00000477909 ENST00000422132(uc003dvn.3 uc010hpn.3)
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPE3
    Sirion Biotech Customized lentivirus for stable overexpression of NXPE3 
                         Customized lentivirus expression plasmids for stable overexpression of NXPE3 
    Primer
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    OriGene qPCR primer pairs and template standards for NXPE3
    OriGene qSTAR qPCR primer pairs in human, mouse for NXPE3
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat NXPE3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPE3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPE3

    Additional mRNA sequence: 

    AF173890.1 AK054664.1 AK289689.1 AY358207.1 BC009431.1 

    15 DOTS entries:

    DT.432457  DT.100710283  DT.40257182  DT.97838054  DT.100718342  DT.120853864  DT.305179  DT.92035303 
    DT.95304428  DT.100710627  DT.120853852  DT.120853855  DT.401752  DT.92416247  DT.95263489 

    24/132 AceView cDNA sequences (see all 132):

    BM683085 AA909631 BM783065 BM783553 BU625881 BM783733 BM783216 BU193227 
    BM783054 BM783118 CR602317 AW074687 AK054664 BM719124 BM759927 BM783762 
    BX401790 AI670696 N55410 BP352800 BQ000568 AY358207 AA442414 CB127312 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXPE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NXPE3 Expression
    About this image


    See NXPE3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXPE3

    SOURCE GeneReport for Unigene cluster: Hs.595933
        SABiosciences Custom PCR Arrays for NXPE3
    Primer
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    OriGene qPCR primer pairs and template standards for NXPE3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NXPE3 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxpe31 , 5 family with sequence similarity 55, member C5
    neurexophilin and PC-esterase domain family, member more1
    85.09(n)1
    88.55(a)1
      16 (33.65 cM)5
    3856581  NM_001134457.11  NP_001127929.11 
     558399535 
    chicken
    (Gallus gallus)
    Aves FAM55C1 family with sequence similarity 55, member C 69.35(n)
    68.82(a)
      418403  XM_416618.3  XP_416618.2 
    lizard
    (Anolis carolinensis)
    Reptilia NXPE36
    neurexophilin and PC-esterase domain family, membe...
    61(a)
    1 ↔ 1
    3(173517985-173536396)
    zebrafish
    (Danio rerio)
    Actinopterygii nxpe31 neurexophilin and PC-esterase domain family, member more 56.62(n)
    52.13(a)
      564277  NM_001077381.1  NP_001070849.1 


    ENSEMBL Gene Tree for NXPE3 (if available)
    TreeFam Gene Tree for NXPE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXPE3 gene
    NXPE22  NXPE12  NXPE42  
    3 SIMAP similar genes for NXPE3 using alignment to 2 protein entries:     NXPE3_HUMAN (see all proteins):
    NXPE2    NXPE4    NXPE1

    NXPE3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/885 SNPs in NXPE3 are shown (see all 885)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467758441,2
    Cuntested1101520627(+) CTCTTC/TCGTTC 4 F syn10--------
    rs1140985231,2
    C,F--101496070(+) GCCTCC/TGTGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1415605231,2
    --101496093(+) AACACA/GGAGTC 1 -- us2k10--------
    rs1508986911,2
    --101496116(+) GAAATA/CTAAAA 1 -- us2k10--------
    rs1889262561,2
    --101496188(+) TGTCTA/GCTCTT 1 -- us2k10--------
    rs1932601731,2
    --101496240(+) TTAATA/TAACAC 1 -- us2k10--------
    rs670571501,2
    C--101496306(+) TATCA-/TTCCT 
            
    TCATA
    2 -- us2k10--------
    rs770664341,2
    C--101496306(+) ATATCT/ATCATA 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1841874071,2
    --101496478(+) ATGAGA/GTCCAA 2 -- us2k10--------
    rs1394280001,2
    --101496554(+) TGAGGC/TGGGGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NXPE3 (101498029 - 101547075 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NXPE3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NXPE3
    DNA2.0 Custom Variant and Variant Library Synthesis for NXPE3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXPE3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NXPE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91775 HGNC: 28238 AceView: MGC15606 Ensembl:ENSG00000144815 euGenes: HUgn91775
    ECgene: NXPE3 H-InvDB: NXPE3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXPE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NXPE3 gene:
    Search GeneIP for patents involving NXPE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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