NXPE3 Gene
protein-coding GIFtS: 36
GCID: GC03P101499
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neurexophilin and PC-esterase domain family, member 3(Previous names: family with sequence similarity 55, member C )
(Previous symbol: FAM55C)
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Aliases
for NXPE3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neurexophilin And PC-Esterase Domain Family, Member 31 2 | | MGC156061 | | FAM55C1 2 3 | | MST1152 | | Family With Sequence Similarity 55, Member C1 2 | | NXPE Family Member 32 | | Protein FAM55C2 3 | | |
Export aliases for NXPE3 gene to outside databases |
Summaries
for NXPE3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NXPE3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NXPE3
Other transcription factors
Search SABiosciences Chromatin IP Primers for NXPE3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPE3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q12.3 Ensembl cytogenetic band: 3q12.3 HGNC cytogenetic band: 3q12.3NXPE3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P101499: view genomic region
(about GC identifiers)
Start:
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101,498,029 bp from pter |
End:
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101,547,075 bp from pter |
Size:
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49,047 bases |
Orientation:
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plus strand |
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Proteins
for NXPE3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NXPE3_HUMAN, Q969Y0 (See
protein sequence)Recommended Name: NXPE family member 3 precursor Size: 559 amino acids; 63800 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAQ13637.1; Type=Frameshift; Positions=345;
Secondary accessions: A8K0X4 D3DN53 Q7Z2S8Explore the universe of human proteins at neXtProt for NXPE3: NX_Q969Y0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969Y0
NXPE3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001127928.1 NP_659474.1
ENSEMBL proteins: ENSP00000418381 ENSP00000273347 ENSP00000419667 ENSP00000417485 ENSP00000418369 ENSP00000396421
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
NXPE3 for ontologies About GeneDecksing
NXPE3 Antibody Products:
Assay Products for NXPE3: |
Protein
Domains /
Families
for NXPE3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NXPE3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969Y0ProtoNet protein and cluster: Q969Y0 UniProtKB/Swiss-Prot: NXPE3_HUMAN, Q969Y0Similarity: Belongs to the NXPE family |
Function
for NXPE3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for NXPE3 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPE3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPE3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPE3 |
1 GenomeRNAi human phenotype for NXPE3:
|
Pathways & Interactions
for NXPE3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXPE3
|
Drugs & Compounds
for NXPE3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NXPE3
Search CenterWatch for drugs/clinical trials and news about NXPE3
|
Transcripts
for NXPE3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NXPE3 gene (2 alternative transcripts): NM_001134456.1 NM_145037.2 Unigene Cluster for NXPE3: Neurexophilin and PC-esterase domain family, member 3 Hs.595933 [show with all ESTs]Unigene Representative Sequence: NM_0011344567 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495842 ENST00000273347 ENST00000474165 ENST00000491511 ENST00000487830
ENST00000477909 ENST00000422132(uc003dvn.3 uc010hpn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for NXPE3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXPE3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPE3 |
Additional cDNA sequence: AF173890.1 AK054664.1 AK289689.1 AY358207.1 BC009431.1 15 DOTS entries: DT.432457 DT.100710283 DT.40257182 DT.97838054 DT.100718342 DT.120853864 DT.305179 DT.92035303 DT.95304428 DT.100710627 DT.120853852 DT.120853855 DT.401752 DT.92416247 DT.95263489 24/132 AceView cDNA sequences (see all 132): AY358207 AI185004 BM719124 BQ000568 AA442414 CR602317 BM758649 BM783118 CB127312 N55410 AA909631 BM783216 BM783054 BM783762 BM783553 BM759927 BP352800 BM783065 BU193227 BU625881 AI670696 AK054664 AW469462 BX401790
GeneLoc Exon Structure
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Expression
for NXPE3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See NXPE3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NXPE3
SOURCE GeneReport for Unigene cluster: Hs.595933
SABiosciences Custom PCR Arrays for NXPE3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXPE3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NXPE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPE3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPE3 |
Orthologs
for NXPE3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NXPE3 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for NXPE3 (if available)
TreeFam Gene Tree for NXPE3 (if available) |
Paralogs
for NXPE3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NXPE3 gene
- NXPE22 NXPE12 NXPE42
3 SIMAP similar genes for NXPE3 using alignment to 2 protein entries: NXPE3_HUMAN (see all proteins):NXPE2 NXPE4 NXPE1
NXPE3 for paralogs About GeneDecksing
|
Genomic Variants
for NXPE3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NXPE3 (101498029 - 101547075 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NXPE3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPE3 |
|
Disorders
/ Diseases
for NXPE3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for NXPE3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NXPE3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NXPE3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NXPE3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NXPE3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing NXPE3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NXPE3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NXPE3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NXPE3 gene:
Search GeneIP for patents involving NXPE3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NXPE3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NXPE3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXPE3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXPE3 | | | OriGene Protein Over-expression Lysate for NXPE3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NXPE3 | | OriGene 3'-UTR Clone for NXPE3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXPE3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NXPE3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NXPE3 | | OriGene Custom Protein Services for NXPE3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NXPE3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXPE3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXPE3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXPE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXPE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXPE3 |
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 |  |  |  | |
| | | | Search Tocris compounds for NXPE3 |
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 | | | NXPE3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXPE3 |
|  |  |  | | | | Search ThermoFisher Antibodies for NXPE3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXPE3 |
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