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Aliases for NXPE2 Gene

Aliases for NXPE2 Gene

  • Neurexophilin And PC-Esterase Domain Family Member 2 2 3 5
  • Family With Sequence Similarity 55, Member B 2 3
  • Protein FAM55B 3 4
  • FAM55B 3 4
  • Neurexophilin And PC-Esterase Domain Family, Member 2 2
  • NXPE Family Member 2 3

External Ids for NXPE2 Gene

Previous HGNC Symbols for NXPE2 Gene

  • FAM55B

Previous GeneCards Identifiers for NXPE2 Gene

  • GC11P114550

Summaries for NXPE2 Gene

GeneCards Summary for NXPE2 Gene

NXPE2 (Neurexophilin And PC-Esterase Domain Family Member 2) is a Protein Coding gene. An important paralog of this gene is NXPE4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE2 Gene

Genomics for NXPE2 Gene

Genomic Location for NXPE2 Gene

Chromosome:
11
Start:
114,648,490 bp from pter
End:
114,707,117 bp from pter
Size:
58,628 bases
Orientation:
Plus strand

Genomic View for NXPE2 Gene

Genes around NXPE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE2 Gene

No data available for Regulatory Elements for NXPE2 Gene

Proteins for NXPE2 Gene

  • Protein details for NXPE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DL1-NXPE2_HUMAN
    Recommended name:
    NXPE family member 2
    Protein Accession:
    Q96DL1
    Secondary Accessions:
    • Q2NKI8

    Protein attributes for NXPE2 Gene

    Size:
    559 amino acids
    Molecular mass:
    64901 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NXPE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXPE2 Gene

Post-translational modifications for NXPE2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NXPE2 Gene

Domains & Families for NXPE2 Gene

Protein Domains for NXPE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NXPE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DL1

UniProtKB/Swiss-Prot:

NXPE2_HUMAN :
  • Belongs to the NXPE family.
Family:
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE2: view

No data available for Gene Families for NXPE2 Gene

Function for NXPE2 Gene

genes like me logo Genes that share phenotypes with NXPE2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NXPE2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPE2 Gene

Localization for NXPE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NXPE2 gene
Compartment Confidence
golgi apparatus 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NXPE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NXPE2: view

Pathways & Interactions for NXPE2 Gene

SuperPathways for NXPE2 Gene

No Data Available

Interacting Proteins for NXPE2 Gene

Gene Ontology (GO) - Biological Process for NXPE2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NXPE2 Gene

Transcripts for NXPE2 Gene

mRNA/cDNA for NXPE2 Gene

(9) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPE2 Gene

Neurexophilin and PC-esterase domain family, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE2 Gene

No ASD Table

Relevant External Links for NXPE2 Gene

GeneLoc Exon Structure for
NXPE2
ECgene alternative splicing isoforms for
NXPE2

Expression for NXPE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NXPE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPE2 Gene

This gene is overexpressed in Colon - Transverse (x22.4) and Minor Salivary Gland (x9.5).

Protein differential expression in normal tissues from HIPED for NXPE2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXPE2 Gene



Protein tissue co-expression partners for NXPE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NXPE2 Gene:

NXPE2

SOURCE GeneReport for Unigene cluster for NXPE2 Gene:

Hs.446760
genes like me logo Genes that share expression patterns with NXPE2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NXPE2 Gene

Orthologs for NXPE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXPE2 34 35
  • 98.93 (n)
cow
(Bos Taurus)
Mammalia NXPE2 34 35
  • 82.53 (n)
rat
(Rattus norvegicus)
Mammalia Nxpe2 34
  • 78.04 (n)
mouse
(Mus musculus)
Mammalia Nxpe2 34 16 35
  • 76.89 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 52 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 51 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495331 34
  • 56.81 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-105h11.2 35
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
Species where no ortholog for NXPE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE2 Gene

ENSEMBL:
Gene Tree for NXPE2 (if available)
TreeFam:
Gene Tree for NXPE2 (if available)

Paralogs for NXPE2 Gene

Paralogs for NXPE2 Gene

(3) SIMAP similar genes for NXPE2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NXPE2 Gene

genes like me logo Genes that share paralogs with NXPE2: view

Variants for NXPE2 Gene

Sequence variations from dbSNP and Humsavar for NXPE2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001999 -- 114,702,095(-) AAGAA(A/G)AAGAC intron-variant
rs10082692 -- 114,772,296(+) ACATT(C/T)GTGGT intron-variant
rs10160431 -- 114,501,161(+) aaacc(C/T)agcag intron-variant, utr-variant-5-prime
rs10219293 -- 114,631,237(+) ATTGC(A/G)GCATT intron-variant
rs10431075 -- 114,553,856(+) TTGGT(A/G)GCTTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NXPE2 Gene

Variant ID Type Subtype PubMed ID
esv3627797 CNV gain 21293372
nsv1053425 CNV loss 25217958
nsv832274 CNV gain 17160897
nsv832275 CNV gain 17160897
nsv975982 CNV duplication 23825009

Variation tolerance for NXPE2 Gene

Gene Damage Index Score: 4.73; 66.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXPE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPE2 Gene

Disorders for NXPE2 Gene

Relevant External Links for NXPE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXPE2

No disorders were found for NXPE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE2 Gene

Publications for NXPE2 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for NXPE2 Gene

Sources for NXPE2 Gene

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