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Aliases for NXPE2 Gene

Aliases for NXPE2 Gene

  • Neurexophilin And PC-Esterase Domain Family, Member 2 2 3
  • Family With Sequence Similarity 55, Member B 2 3
  • Protein FAM55B 3 4
  • FAM55B 3 4

External Ids for NXPE2 Gene

Previous HGNC Symbols for NXPE2 Gene

  • FAM55B

Previous GeneCards Identifiers for NXPE2 Gene

  • GC11P114550

Summaries for NXPE2 Gene

GeneCards Summary for NXPE2 Gene

NXPE2 (Neurexophilin And PC-Esterase Domain Family, Member 2) is a Protein Coding gene. An important paralog of this gene is NXPE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE2 Gene

Genomics for NXPE2 Gene

Genomic Location for NXPE2 Gene

114,648,490 bp from pter
114,707,117 bp from pter
58,628 bases
Plus strand

Genomic View for NXPE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXPE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE2 Gene

No data available for Regulatory Elements for NXPE2 Gene

Proteins for NXPE2 Gene

  • Protein details for NXPE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NXPE family member 2
    Protein Accession:
    Secondary Accessions:
    • Q2NKI8

    Protein attributes for NXPE2 Gene

    559 amino acids
    Molecular mass:
    64901 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NXPE2 Gene


neXtProt entry for NXPE2 Gene

Proteomics data for NXPE2 Gene at MOPED

Post-translational modifications for NXPE2 Gene

No Post-translational modifications

Other Protein References for NXPE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXPE2 Gene

Domains & Families for NXPE2 Gene

Protein Domains for NXPE2 Gene


Suggested Antigen Peptide Sequences for NXPE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NXPE family.
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE2: view

No data available for Gene Families for NXPE2 Gene

Function for NXPE2 Gene

Phenotypes for NXPE2 Gene

genes like me logo Genes that share phenotypes with NXPE2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXPE2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPE2 Gene

Localization for NXPE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE2 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for NXPE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NXPE2: view

No data available for Subcellular locations from COMPARTMENTS for NXPE2 Gene

Pathways & Interactions for NXPE2 Gene

SuperPathways for NXPE2 Gene

No Data Available

Interacting Proteins for NXPE2 Gene

Gene Ontology (GO) - Biological Process for NXPE2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NXPE2 Gene

Drugs & Compounds for NXPE2 Gene

No Compound Related Data Available

Transcripts for NXPE2 Gene

mRNA/cDNA for NXPE2 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPE2 Gene

Neurexophilin and PC-esterase domain family, member 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXPE2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE2 Gene

No ASD Table

Relevant External Links for NXPE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXPE2 Gene

mRNA expression in normal human tissues for NXPE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXPE2 Gene

This gene is overexpressed in Colon - Transverse (x22.4) and Minor Salivary Gland (x9.5).

Protein differential expression in normal tissues from HIPED for NXPE2 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXPE2 Gene

SOURCE GeneReport for Unigene cluster for NXPE2 Gene Hs.446760

genes like me logo Genes that share expression patterns with NXPE2: view

Protein tissue co-expression partners for NXPE2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NXPE2 Gene

Orthologs for NXPE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXPE2 35
  • 82.53 (n)
  • 75.85 (a)
NXPE2 36
  • 75 (a)
(Mus musculus)
Mammalia Nxpe2 35
  • 76.89 (n)
  • 69.34 (a)
Nxpe2 16
Nxpe2 36
  • 69 (a)
(Pan troglodytes)
Mammalia NXPE2 35
  • 98.93 (n)
  • 97.67 (a)
NXPE2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Nxpe2 35
  • 78.04 (n)
  • 71.12 (a)
(Canis familiaris)
Mammalia -- 36
  • 29 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
-- 36
  • 55 (a)
-- 36
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
-- 36
  • 51 (a)
-- 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495331 35
  • 56.81 (n)
  • 49.9 (a)
(Danio rerio)
Actinopterygii si:dkey-105h11.2 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
-- 36
  • 24 (a)
-- 36
  • 21 (a)
-- 36
  • 22 (a)
-- 36
  • 23 (a)
-- 36
  • 23 (a)
-- 36
  • 23 (a)
-- 36
  • 23 (a)
-- 36
  • 22 (a)
Species with no ortholog for NXPE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE2 Gene

Gene Tree for NXPE2 (if available)
Gene Tree for NXPE2 (if available)

Paralogs for NXPE2 Gene

Paralogs for NXPE2 Gene

(3) SIMAP similar genes for NXPE2 Gene using alignment to 1 proteins: Pseudogenes for NXPE2 Gene

genes like me logo Genes that share paralogs with NXPE2: view

Variants for NXPE2 Gene

Sequence variations from dbSNP and Humsavar for NXPE2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs999750 -- 114,702,305(-) CCATG(C/T)ATTAA intron-variant
rs1001999 -- 114,702,095(-) AAGAA(A/G)AAGAC intron-variant
rs1104659 -- 114,671,661(+) aaata(A/G)aataa intron-variant
rs1120449 -- 114,669,586(-) GCTTG(A/G)TATTC intron-variant
rs1356425 -- 114,697,861(+) TGGCA(A/G)CAGAG intron-variant

Variation tolerance for NXPE2 Gene

Gene Damage Index Score: 4.73; 66.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPE2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NXPE2 Gene

Disorders for NXPE2 Gene

Relevant External Links for NXPE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NXPE2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE2 Gene

Publications for NXPE2 Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for NXPE2 Gene

Sources for NXPE2 Gene

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