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Aliases for NXPE1 Gene

Aliases for NXPE1 Gene

  • Neurexophilin And PC-Esterase Domain Family Member 1 2 3 5
  • Family With Sequence Similarity 55, Member A 2 3
  • Protein FAM55A 3 4
  • FAM55A 3 4
  • Neurexophilin And PC-Esterase Domain Family, Member 1 2
  • NXPE Family Member 1 3

External Ids for NXPE1 Gene

Previous HGNC Symbols for NXPE1 Gene

  • FAM55A

Previous GeneCards Identifiers for NXPE1 Gene

  • GC11M114393

Summaries for NXPE1 Gene

GeneCards Summary for NXPE1 Gene

NXPE1 (Neurexophilin And PC-Esterase Domain Family Member 1) is a Protein Coding gene. An important paralog of this gene is NXPE2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE1 Gene

Genomics for NXPE1 Gene

Regulatory Elements for NXPE1 Gene

Enhancers for NXPE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F114569 0.2 ENCODE 11 -10.0 -9950 1.5 CREB3L1 SIN3A DMAP1 ZNF48 GLIS2 FOS ZNF263 YY2 NCOA1 ETV4 NXPE1 LOC100132172
GH11F114288 0.9 ENCODE 9.7 +264.4 264441 13.1 PKNOX1 ARNT FEZF1 ZNF2 YY1 FOS ZNF263 SP3 SP5 REST RBM7 ZW10 LOC101928940 NNMT REXO2 ENSG00000270179 C11orf71 ENSG00000255663 NXPE1 GC11P114306
GH11F114152 2.2 FANTOM5 Ensembl ENCODE 9.7 +389.4 389373 35.9 PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 SP5 LRRC37A13P RBM7 ZW10 NXPE2P1 ZBTB16 NNMT LOC101928940 ENSG00000270179 REXO2 HTR3A
GH11F113772 0.5 ENCODE 9.7 +786.6 786552 1.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 RBM7 REXO2 ZW10 LOC101928940 NNMT ENSG00000270179 NXPE1 DRD2 ENSG00000256603
GH11F114566 0.2 ENCODE 0.4 -6.8 -6785 0.8 NXPE1 LOC100132172
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NXPE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXPE1 Gene

Chromosome:
11
Start:
114,517,732 bp from pter
End:
114,559,895 bp from pter
Size:
42,164 bases
Orientation:
Minus strand

Genomic View for NXPE1 Gene

Genes around NXPE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXPE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXPE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE1 Gene

Proteins for NXPE1 Gene

  • Protein details for NXPE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N323-NXPE1_HUMAN
    Recommended name:
    NXPE family member 1
    Protein Accession:
    Q8N323
    Secondary Accessions:
    • B0YJ13

    Protein attributes for NXPE1 Gene

    Size:
    547 amino acids
    Molecular mass:
    63178 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NXPE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXPE1 Gene

Post-translational modifications for NXPE1 Gene

  • Glycosylation at Asn 39 and Asn 211
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NXPE1 Gene

Domains & Families for NXPE1 Gene

Protein Domains for NXPE1 Gene

Suggested Antigen Peptide Sequences for NXPE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N323

UniProtKB/Swiss-Prot:

NXPE1_HUMAN :
  • Belongs to the NXPE family.
Family:
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE1: view

No data available for Gene Families for NXPE1 Gene

Function for NXPE1 Gene

genes like me logo Genes that share phenotypes with NXPE1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPE1 Gene

Localization for NXPE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXPE1 Gene COMPARTMENTS Subcellular localization image for NXPE1 gene
Compartment Confidence
extracellular 5
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for NXPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NXPE1: view

Pathways & Interactions for NXPE1 Gene

SuperPathways for NXPE1 Gene

No Data Available

Interacting Proteins for NXPE1 Gene

Gene Ontology (GO) - Biological Process for NXPE1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NXPE1 Gene

Transcripts for NXPE1 Gene

mRNA/cDNA for NXPE1 Gene

Unigene Clusters for NXPE1 Gene

Neurexophilin and PC-esterase domain family, member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - - - - -
SP3: -

Relevant External Links for NXPE1 Gene

GeneLoc Exon Structure for
NXPE1
ECgene alternative splicing isoforms for
NXPE1

Expression for NXPE1 Gene

mRNA expression in normal human tissues for NXPE1 Gene

mRNA differential expression in normal tissues according to GTEx for NXPE1 Gene

This gene is overexpressed in Colon - Transverse (x44.7).

Protein differential expression in normal tissues from HIPED for NXPE1 Gene

This gene is overexpressed in Rectum (50.7) and Colon (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXPE1 Gene



Protein tissue co-expression partners for NXPE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NXPE1 Gene:

NXPE1

SOURCE GeneReport for Unigene cluster for NXPE1 Gene:

Hs.721328
genes like me logo Genes that share expression patterns with NXPE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NXPE1 Gene

Orthologs for NXPE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXPE1 34 35
  • 98.68 (n)
rat
(Rattus norvegicus)
Mammalia RGD1566243 34
  • 76.82 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 23 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Nxpe5 35
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 43 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-162k9.5 35
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
-- 35
  • 18 (a)
ManyToMany
-- 35
  • 18 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
-- 35
  • 9 (a)
ManyToMany
Species where no ortholog for NXPE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE1 Gene

ENSEMBL:
Gene Tree for NXPE1 (if available)
TreeFam:
Gene Tree for NXPE1 (if available)

Paralogs for NXPE1 Gene

Paralogs for NXPE1 Gene

(3) SIMAP similar genes for NXPE1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NXPE1 Gene

genes like me logo Genes that share paralogs with NXPE1: view

Variants for NXPE1 Gene

Sequence variations from dbSNP and Humsavar for NXPE1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10431075 -- 114,553,856(+) TTGGT(A/G)GCTTG intron-variant, utr-variant-5-prime
rs10502190 -- 114,557,218(+) TATTA(A/G)TCAAA intron-variant
rs10582306 -- 114,559,620(+) TTTTT(-/TT)GTTTC intron-variant
rs10790019 -- 114,518,986(+) ACAGG(C/T)GTATT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs10790020 -- 114,537,576(+) ACTTC(A/G)GCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXPE1 Gene

Variant ID Type Subtype PubMed ID
dgv725n106 CNV duplication 24896259
esv2302049 CNV deletion 18987734
esv2400658 CNV deletion 18987734
esv2436910 CNV deletion 19546169
esv2543979 CNV deletion 19546169
esv2745094 CNV deletion 23290073
esv2745095 CNV deletion 23290073
esv2745096 CNV deletion 23290073
esv2745098 CNV deletion 23290073
esv2759865 CNV gain 17122850
esv3155800 CNV deletion 24192839
esv3255162 CNV deletion 24192839
esv3417966 CNV duplication 20981092
esv3627791 CNV loss 21293372
esv7013 CNV loss 19470904
nsv1053425 CNV loss 25217958
nsv1075840 CNV duplication 25765185
nsv1113435 CNV deletion 24896259
nsv1113436 CNV deletion 24896259
nsv1119914 CNV deletion 24896259
nsv1122668 CNV deletion 24896259
nsv1130661 CNV deletion 24896259
nsv1145570 CNV deletion 24896259
nsv1147639 CNV duplication 26484159
nsv38546 CNV deletion 16902084
nsv476305 CNV novel sequence insertion 20440878
nsv512241 CNV loss 21212237
nsv832274 CNV gain 17160897
nsv952736 CNV duplication 24416366
nsv975228 CNV duplication 23825009
nsv975980 CNV duplication 23825009

Variation tolerance for NXPE1 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.77; 94.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NXPE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXPE1 Gene

Disorders for NXPE1 Gene

Relevant External Links for NXPE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXPE1

No disorders were found for NXPE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE1 Gene

Publications for NXPE1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3 64
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for NXPE1 Gene

Sources for NXPE1 Gene

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