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Aliases for NXPE1 Gene

Aliases for NXPE1 Gene

  • Neurexophilin And PC-Esterase Domain Family, Member 1 2 3
  • Family With Sequence Similarity 55, Member A 2 3
  • Protein FAM55A 3 4
  • FAM55A 3 4

External Ids for NXPE1 Gene

Previous HGNC Symbols for NXPE1 Gene

  • FAM55A

Previous GeneCards Identifiers for NXPE1 Gene

  • GC11M114393

Summaries for NXPE1 Gene

GeneCards Summary for NXPE1 Gene

NXPE1 (Neurexophilin And PC-Esterase Domain Family, Member 1) is a Protein Coding gene. An important paralog of this gene is NXPE3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXPE1 Gene

Genomics for NXPE1 Gene

Genomic Location for NXPE1 Gene

Chromosome:
11
Start:
114,517,732 bp from pter
End:
114,559,895 bp from pter
Size:
42,164 bases
Orientation:
Minus strand

Genomic View for NXPE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXPE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXPE1 Gene

No data available for Regulatory Elements for NXPE1 Gene

Proteins for NXPE1 Gene

  • Protein details for NXPE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N323-NXPE1_HUMAN
    Recommended name:
    NXPE family member 1
    Protein Accession:
    Q8N323
    Secondary Accessions:
    • B0YJ13

    Protein attributes for NXPE1 Gene

    Size:
    547 amino acids
    Molecular mass:
    63178 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NXPE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXPE1 Gene

Proteomics data for NXPE1 Gene at MOPED

Post-translational modifications for NXPE1 Gene

  • Glycosylation at Asn 39 and Asn 211
  • Modification sites at PhosphoSitePlus

Other Protein References for NXPE1 Gene

No data available for DME Specific Peptides for NXPE1 Gene

Domains & Families for NXPE1 Gene

Protein Domains for NXPE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NXPE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N323

UniProtKB/Swiss-Prot:

NXPE1_HUMAN :
  • Belongs to the NXPE family.
Family:
  • Belongs to the NXPE family.
genes like me logo Genes that share domains with NXPE1: view

No data available for Gene Families for NXPE1 Gene

Function for NXPE1 Gene

Phenotypes for NXPE1 Gene

GenomeRNAi human phenotypes for NXPE1:
genes like me logo Genes that share phenotypes with NXPE1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXPE1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for NXPE1 Gene

Localization for NXPE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXPE1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXPE1 Gene COMPARTMENTS Subcellular localization image for NXPE1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for NXPE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with NXPE1: view

Pathways & Interactions for NXPE1 Gene

SuperPathways for NXPE1 Gene

No Data Available

Interacting Proteins for NXPE1 Gene

Gene Ontology (GO) - Biological Process for NXPE1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NXPE1 Gene

Drugs & Compounds for NXPE1 Gene

No Compound Related Data Available

Transcripts for NXPE1 Gene

mRNA/cDNA for NXPE1 Gene

(11) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXPE1 Gene

Neurexophilin and PC-esterase domain family, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXPE1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXPE1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - - - - -
SP3: -

Relevant External Links for NXPE1 Gene

GeneLoc Exon Structure for
NXPE1
ECgene alternative splicing isoforms for
NXPE1

Expression for NXPE1 Gene

mRNA expression in normal human tissues for NXPE1 Gene

mRNA differential expression in normal tissues according to GTEx for NXPE1 Gene

This gene is overexpressed in Colon - Transverse (x44.7).

Protein differential expression in normal tissues from HIPED for NXPE1 Gene

This gene is overexpressed in Rectum (50.7) and Colon (18.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXPE1 Gene



SOURCE GeneReport for Unigene cluster for NXPE1 Gene Hs.721328

genes like me logo Genes that share expression patterns with NXPE1: view

Protein tissue co-expression partners for NXPE1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NXPE1 Gene

Orthologs for NXPE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NXPE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXPE1 35
  • 98.68 (n)
  • 98.02 (a)
NXPE1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1566243 35
  • 76.82 (n)
  • 69.04 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 23 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nxpe5 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-162k9.5 36
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 12 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
-- 36
  • 12 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 12 (a)
ManyToMany
Species with no ortholog for NXPE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NXPE1 Gene

ENSEMBL:
Gene Tree for NXPE1 (if available)
TreeFam:
Gene Tree for NXPE1 (if available)

Paralogs for NXPE1 Gene

Paralogs for NXPE1 Gene

(3) SIMAP similar genes for NXPE1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NXPE1: view

Variants for NXPE1 Gene

Sequence variations from dbSNP and Humsavar for NXPE1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs475881 -- 114,519,275(-) TTTAT(C/T)ATTAA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs492840 -- 114,522,592(-) TAGGT(A/G)GGGTG intron-variant
rs507995 -- 114,552,907(-) TCATT(A/C)ATTTT intron-variant
rs515678 -- 114,549,255(-) TTTGG(A/G)AGCTT intron-variant
rs524679 -- 114,558,162(+) TTATA(A/T)TTATA intron-variant

Variation tolerance for NXPE1 Gene

Residual Variation Intolerance Score: 66.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.77; 94.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXPE1 Gene

HapMap Linkage Disequilibrium report
NXPE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NXPE1 Gene

Disorders for NXPE1 Gene

Relevant External Links for NXPE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXPE1
genes like me logo Genes that share disorders with NXPE1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXPE1 Gene

Publications for NXPE1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 67
  3. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 67
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for NXPE1 Gene

Sources for NXPE1 Gene

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