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Aliases for NXNL2 Gene

Aliases for NXNL2 Gene

  • Nucleoredoxin-Like 2 2 3 5
  • Rod-Derived Cone Viability Factor 2 3 4
  • C9orf121 3 4
  • RDCVF2 3 4
  • Chromosome 9 Open Reading Frame 121 2
  • Nucleoredoxin-Like Protein 2 3

External Ids for NXNL2 Gene

Previous HGNC Symbols for NXNL2 Gene

  • C9orf121

Previous GeneCards Identifiers for NXNL2 Gene

  • GC09P090340
  • GC09P091150
  • GC09P060978

Summaries for NXNL2 Gene

GeneCards Summary for NXNL2 Gene

NXNL2 (Nucleoredoxin-Like 2) is a Protein Coding gene. An important paralog of this gene is NXNL1.

UniProtKB/Swiss-Prot for NXNL2 Gene

  • May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXNL2 Gene

Genomics for NXNL2 Gene

Regulatory Elements for NXNL2 Gene

Enhancers for NXNL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NXNL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXNL2 Gene

88,535,073 bp from pter
88,584,466 bp from pter
49,394 bases
Plus strand

Genomic View for NXNL2 Gene

Genes around NXNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXNL2 Gene

Proteins for NXNL2 Gene

  • Protein details for NXNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoredoxin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B1AMD0
    • Q8TBG6

    Protein attributes for NXNL2 Gene

    156 amino acids
    Molecular mass:
    17614 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NXNL2 Gene


neXtProt entry for NXNL2 Gene

Post-translational modifications for NXNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXNL2 Gene

No data available for DME Specific Peptides for NXNL2 Gene

Domains & Families for NXNL2 Gene

Protein Domains for NXNL2 Gene


Suggested Antigen Peptide Sequences for NXNL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Belongs to the nucleoredoxin family.
  • Contains 1 thioredoxin domain.
  • Belongs to the nucleoredoxin family.
genes like me logo Genes that share domains with NXNL2: view

No data available for Gene Families for NXNL2 Gene

Function for NXNL2 Gene

Molecular function for NXNL2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons.
genes like me logo Genes that share phenotypes with NXNL2: view

Animal Models for NXNL2 Gene

MGI Knock Outs for NXNL2:

Animal Model Products

CRISPR Products

miRNA for NXNL2 Gene

miRTarBase miRNAs that target NXNL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXNL2 Gene

Localization for NXNL2 Gene

Subcellular locations from

Jensen Localization Image for NXNL2 Gene COMPARTMENTS Subcellular localization image for NXNL2 gene
Compartment Confidence
extracellular 3
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NXNL2 Gene

Pathways & Interactions for NXNL2 Gene

SuperPathways for NXNL2 Gene

No Data Available

Interacting Proteins for NXNL2 Gene

Gene Ontology (GO) - Biological Process for NXNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0007608 sensory perception of smell IEA --
GO:0045494 photoreceptor cell maintenance IEA --
genes like me logo Genes that share ontologies with NXNL2: view

No data available for Pathways by source and SIGNOR curated interactions for NXNL2 Gene

Drugs & Compounds for NXNL2 Gene

No Compound Related Data Available

Transcripts for NXNL2 Gene

mRNA/cDNA for NXNL2 Gene

(5) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXNL2 Gene

Nucleoredoxin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXNL2 Gene

No ASD Table

Relevant External Links for NXNL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXNL2 Gene

mRNA expression in normal human tissues for NXNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXNL2 Gene

This gene is overexpressed in Fallopian Tube (x6.4) and Cervix - Endocervix (x5.7).

Protein differential expression in normal tissues from HIPED for NXNL2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NXNL2 Gene

Protein tissue co-expression partners for NXNL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NXNL2 Gene:


SOURCE GeneReport for Unigene cluster for NXNL2 Gene:

genes like me logo Genes that share expression patterns with NXNL2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NXNL2 Gene

Orthologs for NXNL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXNL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXNL2 34
  • 87.74 (n)
  • 85.81 (a)
NXNL2 35
  • 85 (a)
(Mus musculus)
Mammalia Nxnl2 34
  • 85.16 (n)
  • 85.16 (a)
Nxnl2 16
Nxnl2 35
  • 85 (a)
(Pan troglodytes)
Mammalia NXNL2 34
  • 99.36 (n)
  • 99.36 (a)
NXNL2 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Nxnl2 34
  • 84.95 (n)
  • 83.87 (a)
(Canis familiaris)
Mammalia NXNL2 35
  • 47 (a)
(Monodelphis domestica)
Mammalia NXNL2 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
(Gallus gallus)
Aves NXNL2 34
  • 73.76 (n)
  • 66.45 (a)
NXNL2 35
  • 54 (a)
(Anolis carolinensis)
Reptilia NXNL2 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486090 34
  • 62.34 (n)
  • 59.74 (a)
(Danio rerio)
Actinopterygii Dr.14023 34
nxnl2 34
  • 70.75 (n)
  • 62.58 (a)
nxnl2 35
  • 46 (a)
(Caenorhabditis elegans)
Secernentea C32D5.8 34
  • 53.03 (n)
  • 44.55 (a)
C30H6.8 35
  • 21 (a)
C32D5.8 35
  • 28 (a)
C35B1.5 35
  • 36 (a)
F17B5.1 35
  • 6 (a)
F29B9.5 35
  • 30 (a)
R05H5.3 35
  • 36 (a)
T05F1.11 35
  • 7 (a)
T20D4.7 35
  • 35 (a)
T28A11.13 35
  • 36 (a)
trx-3 35
  • 25 (a)
trx-5 35
  • 35 (a)
Y52E8A.3 35
  • 34 (a)
Species where no ortholog for NXNL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXNL2 Gene

Gene Tree for NXNL2 (if available)
Gene Tree for NXNL2 (if available)

Paralogs for NXNL2 Gene

Paralogs for NXNL2 Gene

(2) SIMAP similar genes for NXNL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXNL2: view

Variants for NXNL2 Gene

Sequence variations from dbSNP and Humsavar for NXNL2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_025755 -
rs7855312 -- 88,558,482(+) gtttc(C/T)ttgat intron-variant
rs7856133 -- 88,553,203(+) tagcc(C/T)ggctt intron-variant
rs7856627 -- 88,546,205(+) AAAAG(A/G)TAGAG intron-variant
rs7856725 -- 88,537,311(+) GTGAG(C/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXNL2 Gene

Variant ID Type Subtype PubMed ID
esv24600 CNV gain 19812545
esv2738719 CNV deletion 23290073
esv2738720 CNV deletion 23290073
esv3573287 CNV loss 25503493
nsv1075252 CNV deletion 25765185
nsv1133734 CNV deletion 24896259
nsv511421 CNV gain 21212237
nsv614812 CNV gain 21841781
nsv614814 CNV gain 21841781
nsv6605 CNV insertion 18451855

Variation tolerance for NXNL2 Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.69; 46.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXNL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXNL2 Gene

Disorders for NXNL2 Gene

Relevant External Links for NXNL2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NXNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXNL2 Gene

Publications for NXNL2 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. (PMID: 22331829) Chasman D.I. … Ridker P.M. (Circ Cardiovasc Genet 2012) 46 65
  5. Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity. (PMID: 20949100) Lambard S. … Zack D.J. (PLoS ONE 2010) 3 65

Products for NXNL2 Gene

Sources for NXNL2 Gene

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