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Aliases for NXNL2 Gene

Aliases for NXNL2 Gene

  • Nucleoredoxin-Like 2 2 3
  • RDCVF2 3 4 6
  • Rod-Derived Cone Viability Factor 2 3 4
  • C9orf121 3 4
  • Chromosome 9 Open Reading Frame 121 2
  • Nucleoredoxin-Like Protein 2 3

External Ids for NXNL2 Gene

Previous HGNC Symbols for NXNL2 Gene

  • C9orf121

Previous GeneCards Identifiers for NXNL2 Gene

  • GC09P090340
  • GC09P091150
  • GC09P060978

Summaries for NXNL2 Gene

GeneCards Summary for NXNL2 Gene

NXNL2 (Nucleoredoxin-Like 2) is a Protein Coding gene. An important paralog of this gene is NXNL1.

UniProtKB/Swiss-Prot for NXNL2 Gene

  • May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXNL2 Gene

Genomics for NXNL2 Gene

Regulatory Elements for NXNL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NXNL2 Gene

88,534,288 bp from pter
88,584,274 bp from pter
49,987 bases
Plus strand

Genomic View for NXNL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXNL2 Gene

Proteins for NXNL2 Gene

  • Protein details for NXNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoredoxin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B1AMD0
    • Q8TBG6

    Protein attributes for NXNL2 Gene

    156 amino acids
    Molecular mass:
    17614 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NXNL2 Gene


neXtProt entry for NXNL2 Gene

Proteomics data for NXNL2 Gene at MOPED

Post-translational modifications for NXNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXNL2 Gene

Antibody Products

No data available for DME Specific Peptides for NXNL2 Gene

Domains for NXNL2 Gene

Protein Domains for NXNL2 Gene


Suggested Antigen Peptide Sequences for NXNL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Belongs to the nucleoredoxin family.
  • Contains 1 thioredoxin domain.
  • Belongs to the nucleoredoxin family.
genes like me logo Genes that share domains with NXNL2: view

No data available for Gene Families for NXNL2 Gene

Function for NXNL2 Gene

Molecular function for NXNL2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons.
genes like me logo Genes that share phenotypes with NXNL2: view

Animal Model Products

CRISPR Products

miRNA for NXNL2 Gene

miRTarBase miRNAs that target NXNL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXNL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for NXNL2 Gene

Localization for NXNL2 Gene

Subcellular locations from

Jensen Localization Image for NXNL2 Gene COMPARTMENTS Subcellular localization image for NXNL2 gene
Compartment Confidence
extracellular 3
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NXNL2 Gene

Pathways for NXNL2 Gene

SuperPathways for NXNL2 Gene

No Data Available

Interacting Proteins for NXNL2 Gene

Gene Ontology (GO) - Biological Process for NXNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0007608 sensory perception of smell IEA --
GO:0045494 photoreceptor cell maintenance IEA --
genes like me logo Genes that share ontologies with NXNL2: view

No data available for Pathways by source for NXNL2 Gene

Transcripts for NXNL2 Gene

mRNA/cDNA for NXNL2 Gene

(5) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXNL2 Gene

Nucleoredoxin-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXNL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXNL2 Gene

No ASD Table

Relevant External Links for NXNL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXNL2 Gene

mRNA expression in normal human tissues for NXNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXNL2 Gene

This gene is overexpressed in Fallopian Tube (6.4) and Cervix - Endocervix (5.7).

Protein differential expression in normal tissues for NXNL2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NXNL2 Gene

SOURCE GeneReport for Unigene cluster for NXNL2 Gene Hs.734507

genes like me logo Genes that share expressions with NXNL2: view

Expression partners for NXNL2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NXNL2 Gene

Orthologs for NXNL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXNL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXNL2 35
  • 87.74 (n)
  • 85.81 (a)
NXNL2 36
  • 85 (a)
(Mus musculus)
Mammalia Nxnl2 35
  • 85.16 (n)
  • 85.16 (a)
Nxnl2 16
Nxnl2 36
  • 85 (a)
(Pan troglodytes)
Mammalia NXNL2 35
  • 99.36 (n)
  • 99.36 (a)
NXNL2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nxnl2 35
  • 84.95 (n)
  • 83.87 (a)
(Canis familiaris)
Mammalia NXNL2 36
  • 47 (a)
(Monodelphis domestica)
Mammalia NXNL2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
(Gallus gallus)
Aves NXNL2 35
  • 73.76 (n)
  • 66.45 (a)
NXNL2 36
  • 54 (a)
(Anolis carolinensis)
Reptilia NXNL2 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486090 35
  • 62.34 (n)
  • 59.74 (a)
(Danio rerio)
Actinopterygii Dr.14023 35
nxnl2 35
  • 70.75 (n)
  • 62.58 (a)
nxnl2 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea C32D5.8 35
  • 53.03 (n)
  • 44.55 (a)
C30H6.8 36
  • 21 (a)
C32D5.8 36
  • 28 (a)
C35B1.5 36
  • 36 (a)
F17B5.1 36
  • 6 (a)
F29B9.5 36
  • 30 (a)
R05H5.3 36
  • 36 (a)
T05F1.11 36
  • 7 (a)
T20D4.7 36
  • 35 (a)
T28A11.13 36
  • 36 (a)
trx-3 36
  • 25 (a)
trx-5 36
  • 35 (a)
Y52E8A.3 36
  • 34 (a)
Species with no ortholog for NXNL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXNL2 Gene

Gene Tree for NXNL2 (if available)
Gene Tree for NXNL2 (if available)

Paralogs for NXNL2 Gene

Paralogs for NXNL2 Gene

(2) SIMAP similar genes for NXNL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXNL2: view

Variants for NXNL2 Gene

Sequence variations from dbSNP and Humsavar for NXNL2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1411674 -- 88,553,388(-) AAGCA(A/T)GGGTT intron-variant
rs2039229 -- 88,541,235(-) GAGAA(C/T)GCAGA intron-variant
rs2104792 -- 88,562,103(-) cctgt(C/G)tagta intron-variant
rs2354559 -- 88,558,089(+) tggtt(A/G)ggggc intron-variant
rs2354560 -- 88,567,438(+) ggGCT(C/T)GAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXNL2 Gene

Variant ID Type Subtype PubMed ID
nsv6605 CNV Insertion 18451855
esv24600 CNV Gain 19812545
nsv511421 CNV Gain 21212237
esv2738719 CNV Deletion 23290073
esv2738720 CNV Deletion 23290073

Relevant External Links for NXNL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXNL2 Gene

Disorders for NXNL2 Gene

Relevant External Links for NXNL2

Genetic Association Database (GAD)

No disorders were found for NXNL2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NXNL2 Gene

Publications for NXNL2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential. (PMID: 17764561) Chalmel F. … Poch O. (BMC Mol. Biol. 2007) 3
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3

Products for NXNL2 Gene

Sources for NXNL2 Gene

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