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Aliases for NXNL1 Gene

Aliases for NXNL1 Gene

  • Nucleoredoxin-Like 1 2 3
  • Thioredoxin-Like Protein 6 3 4
  • Thioredoxin-Like 6 2 3
  • TXNL6 3 4
  • Rod-Derived Cone Viability Factor 3
  • RDCVF 3

External Ids for NXNL1 Gene

Previous HGNC Symbols for NXNL1 Gene

  • TXNL6

Previous GeneCards Identifiers for NXNL1 Gene

  • GC19M017429
  • GC19M017566
  • GC19M017131

Summaries for NXNL1 Gene

GeneCards Summary for NXNL1 Gene

NXNL1 (Nucleoredoxin-Like 1) is a Protein Coding gene. Diseases associated with NXNL1 include retinitis pigmentosa autosomal recessive and bardet-biedl syndrome. An important paralog of this gene is NXNL2.

UniProtKB/Swiss-Prot for NXNL1 Gene

  • May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXNL1 Gene

Genomics for NXNL1 Gene

Regulatory Elements for NXNL1 Gene

Genomic Location for NXNL1 Gene

Chromosome:
19
Start:
17,455,425 bp from pter
End:
17,460,954 bp from pter
Size:
5,530 bases
Orientation:
Minus strand

Genomic View for NXNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXNL1 Gene

Proteins for NXNL1 Gene

  • Protein details for NXNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CM4-NXNL1_HUMAN
    Recommended name:
    Nucleoredoxin-like protein 1
    Protein Accession:
    Q96CM4
    Secondary Accessions:
    • Q0QD37

    Protein attributes for NXNL1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23943 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXNL1 Gene

Proteomics data for NXNL1 Gene at MOPED

Post-translational modifications for NXNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXNL1 Gene

Domains & Families for NXNL1 Gene

Protein Domains for NXNL1 Gene

Suggested Antigen Peptide Sequences for NXNL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CM4

UniProtKB/Swiss-Prot:

NXNL1_HUMAN :
  • Contains 1 thioredoxin domain.
  • Belongs to the nucleoredoxin family.
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the nucleoredoxin family.
genes like me logo Genes that share domains with NXNL1: view

No data available for Gene Families for NXNL1 Gene

Function for NXNL1 Gene

Molecular function for NXNL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.
genes like me logo Genes that share phenotypes with NXNL1: view

Animal Models for NXNL1 Gene

MGI Knock Outs for NXNL1:

Animal Model Products

miRNA for NXNL1 Gene

miRTarBase miRNAs that target NXNL1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXNL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for NXNL1 Gene

Localization for NXNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXNL1 Gene

Nucleus outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXNL1 Gene COMPARTMENTS Subcellular localization image for NXNL1 gene
Compartment Confidence
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NXNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005640 nuclear outer membrane IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NXNL1: view

Pathways & Interactions for NXNL1 Gene

SuperPathways for NXNL1 Gene

No Data Available

Interacting Proteins for NXNL1 Gene

Gene Ontology (GO) - Biological Process for NXNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045494 photoreceptor cell maintenance IEA --
genes like me logo Genes that share ontologies with NXNL1: view

No data available for Pathways by source and SIGNOR curated interactions for NXNL1 Gene

Drugs & Compounds for NXNL1 Gene

No Compound Related Data Available

Transcripts for NXNL1 Gene

mRNA/cDNA for NXNL1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXNL1 Gene

Nucleoredoxin-like 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXNL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXNL1 Gene

No ASD Table

Relevant External Links for NXNL1 Gene

GeneLoc Exon Structure for
NXNL1
ECgene alternative splicing isoforms for
NXNL1

Expression for NXNL1 Gene

mRNA expression in normal human tissues for NXNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NXNL1 Gene

This gene is overexpressed in Adrenal (29.7), Retina (20.8), Kidney (8.3), and Islet of Langerhans (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NXNL1 Gene



SOURCE GeneReport for Unigene cluster for NXNL1 Gene Hs.661836

genes like me logo Genes that share expression patterns with NXNL1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NXNL1 Gene

Orthologs for NXNL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXNL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NXNL1 35
  • 86.6 (n)
  • 87.3 (a)
NXNL1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXNL1 35
  • 87.79 (n)
  • 86.63 (a)
NXNL1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nxnl1 35
  • 80.18 (n)
  • 83.16 (a)
Nxnl1 16
Nxnl1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NXNL1 35
  • 98.55 (n)
  • 99.13 (a)
NXNL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxnl1 35
  • 81.58 (n)
  • 83.68 (a)
oppossum
(Monodelphis domestica)
Mammalia NXNL1 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves NXNL1 35
  • 66.84 (n)
  • 58.12 (a)
NXNL1 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NXNL1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxnl1 35
  • 61.55 (n)
  • 59.26 (a)
zebrafish
(Danio rerio)
Actinopterygii nxnl1 35
  • 61.38 (n)
  • 55.56 (a)
NXNL1 (1 of 2) 36
  • 50 (a)
OneToMany
NXNL1 (2 of 2) 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C30H6.8 36
  • 19 (a)
ManyToMany
C32D5.8 36
  • 25 (a)
ManyToMany
C35B1.5 36
  • 27 (a)
ManyToMany
F17B5.1 36
  • 4 (a)
ManyToMany
F29B9.5 36
  • 25 (a)
ManyToMany
R05H5.3 36
  • 28 (a)
ManyToMany
T05F1.11 36
  • 4 (a)
ManyToMany
T20D4.7 36
  • 28 (a)
ManyToMany
T28A11.13 36
  • 27 (a)
ManyToMany
trx-3 36
  • 19 (a)
ManyToMany
trx-5 36
  • 26 (a)
ManyToMany
Y52E8A.3 36
  • 28 (a)
ManyToMany
Species with no ortholog for NXNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXNL1 Gene

ENSEMBL:
Gene Tree for NXNL1 (if available)
TreeFam:
Gene Tree for NXNL1 (if available)

Paralogs for NXNL1 Gene

Paralogs for NXNL1 Gene

(1) SIMAP similar genes for NXNL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXNL1: view

Variants for NXNL1 Gene

Sequence variations from dbSNP and Humsavar for NXNL1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs890839 -- 17,460,957(-) GGTTT(C/T)CTAAA upstream-variant-2KB
rs1864006 -- 17,461,064(-) AATGC(A/G)TTTGC upstream-variant-2KB
rs2162778 -- 17,458,793(-) gaaac(A/C)ccgtc intron-variant
rs4808646 -- 17,456,187(+) TGGCT(A/G)TGCCC intron-variant
rs6512194 -- 17,459,393(+) CTGTA(A/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXNL1 Gene

Variant ID Type Subtype PubMed ID
nsv911182 CNV Loss 21882294
nsv833768 CNV Loss 17160897
dgv3761n71 CNV Loss 21882294
nsv911203 CNV Loss 21882294
nsv911205 CNV Loss 21882294

Variation tolerance for NXNL1 Gene

Residual Variation Intolerance Score: 81.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXNL1 Gene

HapMap Linkage Disequilibrium report
NXNL1
Human Gene Mutation Database (HGMD)
NXNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXNL1 Gene

Disorders for NXNL1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NXNL1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa autosomal recessive
  • retinitis pigmentosa
bardet-biedl syndrome
  • biedl-bardet syndrome
leber congenital amaurosis
  • leber's amaurosis
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association
Search NXNL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NXNL1

Genetic Association Database (GAD)
NXNL1
Human Genome Epidemiology (HuGE) Navigator
NXNL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXNL1
genes like me logo Genes that share disorders with NXNL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXNL1 Gene

Publications for NXNL1 Gene

  1. The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina. (PMID: 19843539) Reichman S. … LAcveillard T. (Hum. Mol. Genet. 2010) 23 67
  2. Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa. (PMID: 19277021) Yang Y. … Sahel J.A. (Mol. Ther. 2009) 23 67
  3. The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina. (PMID: 19279044) Fridlich R. … LAcveillard T. (Mol. Cell Proteomics 2009) 23 67
  4. Thioredoxin-like 6 protects retinal cell line from photooxidative damage by upregulating NF-kappaB activity. (PMID: 18474255) Wang X.W. … Ding J.L. (Free Radic. Biol. Med. 2008) 23 67
  5. An evolutionarily conserved 16-kDa thioredoxin-related protein is an antioxidant which regulates the NF-kappaB signaling pathway. (PMID: 17189830) Wang X.W. … Ding J.L. (Free Radic. Biol. Med. 2007) 23 67

Products for NXNL1 Gene

Sources for NXNL1 Gene

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