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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXNL1 Gene

protein-coding   GIFtS: 51
GCID: GC19M017566

Nucleoredoxin-Like 1

(Previous name: thioredoxin-like 6)
(Previous symbol: TXNL6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleoredoxin-Like 11 2     RDCVF2
TXNL61 2 3     Nucleoredoxin-Like Protein 12
Thioredoxin-Like 61 2     Rod-Derived Cone Viability Factor2
Thioredoxin-Like Protein 62 3     

External Ids:    HGNC: 251791   Entrez Gene: 1158612   Ensembl: ENSG000001717737   OMIM: 6087915   UniProtKB: Q96CM43   

Export aliases for NXNL1 gene to outside databases

Previous GC identifers: GC19M017429 GC19M017131


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NXNL1 Gene: 
NXNL1 (nucleoredoxin-like 1) is a protein-coding gene. Diseases associated with NXNL1 include bardet-biedl syndrome, and leber congenital amaurosis. An important paralog of this gene is NXNL2.

UniProtKB/Swiss-Prot: NXNL1_HUMAN, Q96CM4
Function: May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in
degenerating rods (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NXNL1 gene promoter:
         Sp1   MyoD   RORalpha2   Egr-2   PPAR-gamma1   c-Myb   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXNL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NXNL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.12

NXNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXNL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017566:  view genomic region     (about GC identifiers)

Start:
17,566,234 bp from pter      End:
17,571,763 bp from pter
Size:
5,530 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NXNL1_HUMAN, Q96CM4 (See protein sequence)
Recommended Name: Nucleoredoxin-like protein 1  
Size: 212 amino acids; 23943 Da
Subcellular location: Nucleus outer membrane (By similarity)

Explore the universe of human proteins at neXtProt for NXNL1: NX_Q96CM4

Explore proteomics data for NXNL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96CM4

  • NXNL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NXNL1 Protein Expression
    REFSEQ proteins: NP_612463.1  
    ENSEMBL proteins: 
     ENSP00000305631  

    Human Recombinant Protein Products for NXNL1: 
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    OriGene Custom Protein Services for NXNL1
    GenScript Custom Purified and Recombinant Proteins Services for NXNL1
    Novus Biologicals NXNL1 Proteins
    Novus Biologicals NXNL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NXNL1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005640nuclear outer membrane IEA--
    GO:0005739mitochondrion IEA--

    NXNL1 for ontologies           About GeneDecksing



    NXNL1 Antibody Products: 
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    Assay Products for NXNL1: 
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    Cloud-Clone Corp. ELISAs for NXNL1 
    Cloud-Clone Corp. CLIAs for NXNL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q96CM4

    ProtoNet protein and cluster: Q96CM4

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: NXNL1_HUMAN, Q96CM4
    Similarity: Belongs to the nucleoredoxin family
    Similarity: Contains 1 thioredoxin domain


    NXNL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXNL1_HUMAN, Q96CM4
    Function: May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in
    degenerating rods (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for NXNL1:

     Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nxnl1):
     hematopoietic system  homeostasis/metabolism  immune system  nervous system  no phenotypic analysis 
     vision/eye 

    NXNL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nxnl1tm1.2Tlev for NXNL1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NXNL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NXNL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXNL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NXNL1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXNL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NXNL1
    SwitchGear 3'UTR luciferase reporter plasmidNXNL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NXNL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXNL1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of NXNL1

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for NXNL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NXNL1 (NM_138454)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXNL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXNL1
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                         Customized lentivirus expression plasmids for stable overexpression of NXNL1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NXNL1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXNL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXNL1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for NXNL1 (Q96CM43 ENSP000003056314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLIIQ130453I2D: score=1 
    POT1ENSP000003502494STRING: ENSP00000350249
    TERF1ENSP000002766034STRING: ENSP00000276603
    TERF2ENSP000002549424STRING: ENSP00000254942
    TERF2IPENSP000003000864STRING: ENSP00000300086
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXNL1

    Search CenterWatch for drugs/clinical trials and news about NXNL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NXNL1 gene: 
    NM_138454.1  

    Unigene Cluster for NXNL1:

    Nucleoredoxin-like 1
    Hs.661836  [show with all ESTs]
    Unigene Representative Sequence: BM460222
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301944(uc002ngs.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXNL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NXNL1
    SwitchGear 3'UTR luciferase reporter plasmidNXNL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NXNL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXNL1
    Clone
    Products:
         
    OriGene clones in human, mouse for NXNL1 (see all 8)
    OriGene ORF clones in mouse, rat for NXNL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NXNL1 (NM_138454)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXNL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXNL1
    Sirion Biotech Customized lentivirus for stable overexpression of NXNL1 
                         Customized lentivirus expression plasmids for stable overexpression of NXNL1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NXNL1
    OriGene qSTAR qPCR primer pairs in human, mouse for NXNL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NXNL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXNL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXNL1

    Additional mRNA sequence: 

    BC014127.1 DQ426894.1 

    1 DOTS entry:

    DT.95240881 

    17 AceView cDNA sequences:

    BM846285 BM703164 BG395178 BQ638311 CB153710 BQ639327 BC014127 NM_138454 
    BM846283 BM664663 BM847087 BC039402 BM925642 BI560556 BM460222 BQ440125 
    BI598673 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXNL1 expression in normal human tissues (normalized intensities)      NXNL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAGAAAT
    NXNL1 Expression
    About this image


    NXNL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Mature Rod Cells Outer Nuclear Layer
             Retina
             retina   

    See NXNL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXNL1

    SOURCE GeneReport for Unigene cluster: Hs.661836
        SABiosciences Custom PCR Arrays for NXNL1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NXNL1
    OriGene qSTAR qPCR primer pairs in human, mouse for NXNL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NXNL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXNL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXNL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXNL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NXNL1 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxnl11 , 5 nucleoredoxin-like 11, 5 78.32(n)1
    80.1(a)1
      8 (34.43 cM)5
    2344041  NM_145598.21  NP_663573.11 
     715605565 
    chicken
    (Gallus gallus)
    Aves NXNL11 nucleoredoxin-like 1 66.17(n)
    56.65(a)
      426009  XM_423688.1  XP_423688.1 
    lizard
    (Anolis carolinensis)
    Reptilia NXNL16
    Uncharacterized protein
    54(a)
    1 ↔ 1
    GL343198.1(3876053-3880402)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003308841 nucleoredoxin-like protein 1-like 59.52(n)
    53.81(a)
      100330884  XM_002664746.1  XP_002664792.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R05H5.36
    C35B1.56
    (see all 6)
    Protein C35B1.5
    (see all 6)
    29(a)
    28(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    II(10197400-10198603)
    IV(4083588-4084215)


    ENSEMBL Gene Tree for NXNL1 (if available)
    TreeFam Gene Tree for NXNL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXNL1 gene
    NXNL22  NXN2  
    1 SIMAP similar gene for NXNL1 using alignment to 1 protein entry:     NXNL1_HUMAN:
    NXNL2

    NXNL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 SNPs in NXNL1 are shown (see all 214)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1140704741,2
    C--17565799(+) GGCAGG/ACTTTT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs2007360051,2
    C--17565857(+) AACAG-/CCCCCC 1 -- int10--------
    rs1118217791,2
    C,F--17565907(+) TCCGCC/TGGGGC 1 -- int11Minor allele frequency- T:0.23NA 120
    rs1146337941,2
    F--17566232(+) CTCAGC/GCTTCA 1 -- spd11Minor allele frequency- G:0.05WA 118
    rs1833714941,2
    --17566273(+) CACCGA/GGCTAA 1 -- ut310--------
    rs1877768731,2
    --17566357(+) CTCCCA/GCCTTG 1 -- ut310--------
    rs563842971,2
    C--17566409(+) TGGGGG/TTGGAG 1 -- ut313Minor allele frequency- T:0.23NA CSA 123
    rs560845151,2
    C--17566562(+) ACTCGG/ATGAGG 2 /T /I mis11Minor allele frequency- A:0.50NA 2
    rs2016241691,2
    --17566574(+) TCCGTA/GGCTCC 2 P L mis10--------
    rs2011590271,2
    --17566605(+) CAGCTG/TGAAGT 2 K Q mis10--------

    HapMap Linkage Disequilibrium report for NXNL1 (17566234 - 17571763 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NXNL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911182CNV Loss21882294
    dgv3761n71CNV Loss21882294
    nsv911205CNV Loss21882294
    nsv833768CNV Loss17160897
    nsv911203CNV Loss21882294


    Human Gene Mutation Database (HGMD): NXNL1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NXNL1
    DNA2.0 Custom Variant and Variant Library Synthesis for NXNL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608791    OMIM disorders: --

    6 diseases for NXNL1:    About MalaCards
    bardet-biedl syndrome    leber congenital amaurosis    retinitis pigmentosa    blindness
    retinal degeneration    retinitis

    1 disease from the University of Copenhagen DISEASES database for NXNL1:
    Retinitis pigmentosa

    NXNL1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for NXNL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 82.9 7 19843539 (4), 15639013 (1), 19277021 (1)
    blindness 46.3 3 19843539 (2)

    Genetic Association Database (GAD): NXNL1
    Human Genome Epidemiology (HuGE) Navigator: NXNL1 (1 document)

    Export disorders for NXNL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXNL1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with NXNL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population. (PubMed id 19402160)1, 4 Bin J....HAcon E. (2009)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Thioredoxin-like 6 protects retinal cell line from photooxidative damage by upregulating NF-kappaB activity. (PubMed id 18474255)1, 9 Wang X.W....Ding J.L. (2008)
    4. The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina. (PubMed id 19843539)1, 9 Reichman S....LAcveillard T. (2010)
    5. Identification and characterization of rod-derived cone viability factor. (PubMed id 15220920)1, 9 Leveillard T....Sahel J.A. (2004)
    6. Disease-associated variants of the rod-derived cone viability factor (RdCVF) in Leber congenital amaurosis. Rod-derived cone viability variants in LCA. (PubMed id 17249548)1, 9 Hanein S....Leveillard T. (2006)
    7. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    8. TXNL6 is a novel oxidative stress-induced reducing sy stem for methionine sulfoxide reductase a repair of I+-crystallin and cytochrome C in the eye lens. (PubMed id 21079812)1 Brennan L.A....Kantorow M. (2010)
    9. Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity. (PubMed id 20949100)1 Lambard S....Zack D.J. (2010)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115861 HGNC: 25179 AceView: TXNL6 Ensembl:ENSG00000171773 euGenes: HUgn115861
    ECgene: NXNL1 H-InvDB: NXNL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXNL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NXNL1 gene:
    Search GeneIP for patents involving NXNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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