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Aliases for NXNL1 Gene

Aliases for NXNL1 Gene

  • Nucleoredoxin-Like 1 2 3
  • TXNL6 3 4 6
  • Thioredoxin-Like Protein 6 3 4
  • Thioredoxin-Like 6 2 3
  • RDCVF 3 6
  • Rod-Derived Cone Viability Factor 3
  • Nucleoredoxin-Like Protein 1 3
  • LOC115861 6

External Ids for NXNL1 Gene

Previous HGNC Symbols for NXNL1 Gene

  • TXNL6

Previous GeneCards Identifiers for NXNL1 Gene

  • GC19M017429
  • GC19M017566
  • GC19M017131

Summaries for NXNL1 Gene

GeneCards Summary for NXNL1 Gene

NXNL1 (Nucleoredoxin-Like 1) is a Protein Coding gene. Diseases associated with NXNL1 include leber congenital amaurosis and bardet-biedl syndrome. An important paralog of this gene is NXNL2.

UniProtKB/Swiss-Prot for NXNL1 Gene

  • May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXNL1 Gene

Genomics for NXNL1 Gene

Regulatory Elements for NXNL1 Gene

Genomic Location for NXNL1 Gene

17,455,425 bp from pter
17,460,954 bp from pter
5,530 bases
Minus strand

Genomic View for NXNL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXNL1 Gene

Proteins for NXNL1 Gene

  • Protein details for NXNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleoredoxin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q0QD37

    Protein attributes for NXNL1 Gene

    212 amino acids
    Molecular mass:
    23943 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NXNL1 Gene

Proteomics data for NXNL1 Gene at MOPED

Post-translational modifications for NXNL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXNL1 Gene

Domains for NXNL1 Gene

Protein Domains for NXNL1 Gene

Suggested Antigen Peptide Sequences for NXNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96CM4
  • Contains 1 thioredoxin domain.
  • Belongs to the nucleoredoxin family.
genes like me logo Genes that share domains with NXNL1: view

No data available for Gene Families for NXNL1 Gene

Function for NXNL1 Gene

Molecular function for NXNL1 Gene

UniProtKB/Swiss-Prot Function: May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.
genes like me logo Genes that share phenotypes with NXNL1: view

Animal Models for NXNL1 Gene

MGI Knock Outs for NXNL1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXNL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targeting and HOMER Transcription for NXNL1 Gene

Localization for NXNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXNL1 Gene

Nucleus outer membrane.

Subcellular locations from

Jensen Localization Image for NXNL1 Gene COMPARTMENTS Subcellular localization image for NXNL1 gene
Compartment Confidence
cytosol 2
extracellular 2
mitochondrion 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NXNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005640 nuclear outer membrane IEA --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with NXNL1: view

Pathways for NXNL1 Gene

SuperPathways for NXNL1 Gene

No Data Available

Interacting Proteins for NXNL1 Gene

Gene Ontology (GO) - Biological Process for NXNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045494 photoreceptor cell maintenance IEA --
genes like me logo Genes that share ontologies with NXNL1: view

No data available for Pathways by source for NXNL1 Gene

Transcripts for NXNL1 Gene

mRNA/cDNA for NXNL1 Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXNL1 Gene

Nucleoredoxin-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXNL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXNL1 Gene

No ASD Table

Relevant External Links for NXNL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXNL1 Gene

mRNA expression in normal human tissues for NXNL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NXNL1 Gene

SOURCE GeneReport for Unigene cluster for NXNL1 Gene Hs.661836

genes like me logo Genes that share expressions with NXNL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NXNL1 Gene

Orthologs for NXNL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXNL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NXNL1 35
  • 98.55 (n)
  • 99.13 (a)
NXNL1 36
  • 100 (a)
(Bos Taurus)
Mammalia NXNL1 35
  • 86.6 (n)
  • 87.3 (a)
NXNL1 36
  • 79 (a)
(Canis familiaris)
Mammalia NXNL1 35
  • 87.79 (n)
  • 86.63 (a)
NXNL1 36
  • 81 (a)
(Mus musculus)
Mammalia Nxnl1 35
  • 80.18 (n)
  • 83.16 (a)
Nxnl1 16
Nxnl1 36
  • 74 (a)
(Monodelphis domestica)
Mammalia NXNL1 36
  • 59 (a)
(Rattus norvegicus)
Mammalia Nxnl1 35
  • 81.58 (n)
  • 83.68 (a)
(Gallus gallus)
Aves NXNL1 35
  • 66.84 (n)
  • 58.12 (a)
NXNL1 36
  • 55 (a)
(Anolis carolinensis)
Reptilia NXNL1 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nxnl1 35
  • 61.55 (n)
  • 59.26 (a)
(Danio rerio)
Actinopterygii nxnl1 35
  • 61.38 (n)
  • 55.56 (a)
NXNL1 (1 of 2) 36
  • 50 (a)
NXNL1 (2 of 2) 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea C30H6.8 36
  • 19 (a)
C32D5.8 36
  • 25 (a)
C35B1.5 36
  • 27 (a)
F17B5.1 36
  • 4 (a)
F29B9.5 36
  • 25 (a)
R05H5.3 36
  • 28 (a)
T05F1.11 36
  • 4 (a)
T20D4.7 36
  • 28 (a)
T28A11.13 36
  • 27 (a)
trx-3 36
  • 19 (a)
trx-5 36
  • 26 (a)
Y52E8A.3 36
  • 28 (a)
Species with no ortholog for NXNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXNL1 Gene

Gene Tree for NXNL1 (if available)
Gene Tree for NXNL1 (if available)

Paralogs for NXNL1 Gene

Paralogs for NXNL1 Gene

Selected SIMAP similar genes for NXNL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXNL1: view

Variants for NXNL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NXNL1 Gene

Variant ID Type Subtype PubMed ID
nsv911182 CNV Loss 21882294
nsv833768 CNV Loss 17160897
dgv3761n71 CNV Loss 21882294
nsv911203 CNV Loss 21882294
nsv911205 CNV Loss 21882294

Relevant External Links for NXNL1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NXNL1 Gene

Disorders for NXNL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for NXNL1 Gene including...

Search for NXNL1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NXNL1 Gene

(2) Novoseek inferred disease relationships for NXNL1 Gene

Disease -log(P) Hits PubMed IDs
retinitis pigmentosa 82.9 6
blindness 46.3 2

Relevant External Links for NXNL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NXNL1: view

No data available for UniProtKB/Swiss-Prot for NXNL1 Gene

Publications for NXNL1 Gene

  1. Identification and characterization of rod-derived cone viability factor. (PMID: 15220920) LAcveillard T. … Sahel J.A. (Nat. Genet. 2004) 3 23
  2. Disease-associated variants of the rod-derived cone viability factor (RdCVF) in Leber congenital amaurosis. Rod-derived cone viability variants in LCA. (PMID: 17249548) Hanein S. … Leveillard T. (Adv. Exp. Med. Biol. 2006) 3 23
  3. Thioredoxin-like 6 protects retinal cell line from photooxidative damage by upregulating NF-kappaB activity. (PMID: 18474255) Wang X.W. … Ding J.L. (Free Radic. Biol. Med. 2008) 3 23
  4. The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina. (PMID: 19843539) Reichman S. … LAcveillard T. (Hum. Mol. Genet. 2010) 3 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3

Products for NXNL1 Gene

Sources for NXNL1 Gene

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