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NXNL1 Gene

protein-coding   GIFtS: 49
GCID: GC19M017566

Nucleoredoxin-Like 1

(Previous name: thioredoxin-like 6)
(Previous symbol: TXNL6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoredoxin-Like 11 2     RDCVF2 5
TXNL61 2 3 5     Nucleoredoxin-Like Protein 12
Thioredoxin-Like 61 2     Rod-Derived Cone Viability Factor2
Thioredoxin-Like Protein 62 3     LOC1158615

External Ids:    HGNC: 251791   Entrez Gene: 1158612   Ensembl: ENSG000001717737   OMIM: 6087915   UniProtKB: Q96CM43   

Export aliases for NXNL1 gene to outside databases

Previous GC identifers: GC19M017429 GC19M017131


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NXNL1 Gene:
NXNL1 (nucleoredoxin-like 1) is a protein-coding gene. Diseases associated with NXNL1 include cone dystrophy, and bardet-biedl syndrome. An important paralog of this gene is NXNL2.

UniProtKB/Swiss-Prot: NXNL1_HUMAN, Q96CM4
Function: May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in
degenerating rods (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the NXNL1 gene promoter:
         Sp1   MyoD   RORalpha2   Egr-2   PPAR-gamma1   c-Myb   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXNL1 promoter sequence
   Search Chromatin IP Primers for NXNL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NXNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.12

NXNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXNL1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017566:  view genomic region     (about GC identifiers)

Start:
17,566,234 bp from pter      End:
17,571,763 bp from pter
Size:
5,530 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NXNL1_HUMAN, Q96CM4 (See protein sequence)
Recommended Name: Nucleoredoxin-like protein 1  
Size: 212 amino acids; 23943 Da
Secondary accessions: Q0QD37

Explore the universe of human proteins at neXtProt for NXNL1: NX_Q96CM4

Explore proteomics data for NXNL1 at MOPED


See NXNL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_612463.1  
ENSEMBL proteins: 
 ENSP00000305631  

NXNL1 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for NXNL1

NXNL1 Assay Products:

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Cloud-Clone Corp. CLIAs for NXNL1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR012336 Thioredoxin-like_fold

Graphical View of Domain Structure for InterPro Entry Q96CM4

ProtoNet protein and cluster: Q96CM4

1 Blocks protein domain: IPB006662 Thioredoxin type domain

UniProtKB/Swiss-Prot: NXNL1_HUMAN, Q96CM4
Similarity: Belongs to the nucleoredoxin family
Similarity: Contains 1 thioredoxin domain


NXNL1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NXNL1_HUMAN, Q96CM4
Function: May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in
degenerating rods (By similarity)

Phenotypes:
     1 GenomeRNAi human phenotype for NXNL1:

 Decreased viability of wild-ty 

     6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nxnl1):
 hematopoietic system  homeostasis/metabolism  immune system  nervous system  no phenotypic analysis 
 vision/eye 

NXNL1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Nxnl1tm1.2Tlev for NXNL1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NXNL1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NXNL1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXNL1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NXNL1

miRNA
Products:
    
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SwitchGear 3'UTR luciferase reporter plasmidNXNL1 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for NXNL1
Predesigned siRNA for gene silencing in human, mouse, rat NXNL1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for NXNL1

Clone
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OriGene clones in human, mouse for NXNL1 (see all 7)
OriGene ORF clones in mouse, rat for NXNL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NXNL1 (NM_138454)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXNL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXNL1

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for NXNL1 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXNL1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NXNL1_HUMAN, Q96CM4: Nucleus outer membrane (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
extracellular2
mitochondrion2
nucleus2
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005640nuclear outer membrane IEA--
GO:0005739mitochondrion IEA--

NXNL1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NXNL1
Interactions:

    Search GeneGlobe Interaction Network for NXNL1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for NXNL1 (Q96CM43 ENSP000003056314) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
FLIIQ130453I2D: score=1 
POT1ENSP000003502494STRING: ENSP00000350249
TERF1ENSP000002766034STRING: ENSP00000276603
TERF2ENSP000002549424STRING: ENSP00000254942
TERF2IPENSP000003000864STRING: ENSP00000300086
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NXNL1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NXNL1 gene: 
NM_138454.1  

Unigene Cluster for NXNL1:

Nucleoredoxin-like 1
Hs.661836  [show with all ESTs]
Unigene Representative Sequence: BM460222
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000301944(uc002ngs.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NXNL1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate NXNL1
SwitchGear 3'UTR luciferase reporter plasmidNXNL1 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for NXNL1
Predesigned siRNA for gene silencing in human, mouse, rat NXNL1
Clone
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OriGene clones in human, mouse for NXNL1 (see all 7)
OriGene ORF clones in mouse, rat for NXNL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NXNL1 (NM_138454)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXNL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXNL1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for NXNL1
OriGene qSTAR qPCR primer pairs in human, mouse for NXNL1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXNL1
  QuantiTect SYBR Green Assays in human, mouse, rat NXNL1
  QuantiFast Probe-based Assays in human, mouse, rat NXNL1

Additional mRNA sequence: 

BC014127.1 DQ426894.1 

1 DOTS entry:

DT.95240881 

17 AceView cDNA sequences:

BM703164 BM664663 BC014127 BM846283 BQ639327 BG395178 CB153710 BM846285 
BQ638311 NM_138454 BM847087 BQ440125 BI560556 BM460222 BC039402 BM925642 
BI598673 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NXNL1 expression in normal human tissues (normalized intensities)      NXNL1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCAAAGAAAT
NXNL1 Expression
About this image


NXNL1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Mature Rod Cells Outer Nuclear Layer
         Retina
 
 Neurons
         Mature Rod Cells Outer Nuclear Layer
NXNL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NXNL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.661836
    Custom PCR Arrays for NXNL1
Primer
Products:
OriGene qPCR primer pairs and template standards for NXNL1
OriGene qSTAR qPCR primer pairs in human, mouse for NXNL1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXNL1
QuantiTect SYBR Green Assays in human, mouse, rat NXNL1
QuantiFast Probe-based Assays in human, mouse, rat NXNL1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXNL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NXNL1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nxnl11 , 5 nucleoredoxin-like 11, 5 80.18(n)1
83.16(a)1
  8 (34.43 cM)5
2344041  NM_145598.21  NP_663573.11 
 715605565 
chicken
(Gallus gallus)
Aves NXNL11 nucleoredoxin-like 1 66.84(n)
58.12(a)
  426009  XM_423688.2  XP_423688.1 
lizard
(Anolis carolinensis)
Reptilia NXNL16
nucleoredoxin-like 1
54(a)
1 ↔ 1
GL343198.1(3876053-3880402)
tropical clawed frog
(Xenopus tropicalis)
Amphibia nxnl11 nucleoredoxin-like 1 61.55(n)
59.26(a)
  100491275  XM_002935423.2  XP_002935469.1 
zebrafish
(Danio rerio)
Actinopterygii nxnl11 novel protein similar to vertebrate thioredoxin-like more 61.38(n)
55.56(a)
  567911  NM_001110760.1  NP_001104230.1 
worm
(Caenorhabditis elegans)
Secernentea F17B5.16
T05F1.116
(see all 12)
Protein T05F1.11 (T05F1.11) mRNA, complete cds
(see all 12)
4(a)
4(a)
(see all 12)
many ↔ many
many ↔ many
(see all 12)
I(13184912-13188297) WBGene00008905
I(9653101-9657040) WBGene00011495


ENSEMBL Gene Tree for NXNL1 (if available)
TreeFam Gene Tree for NXNL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NXNL1 gene
NXNL22  NXN2  
1 SIMAP similar gene for NXNL1 using alignment to 1 protein entry:     NXNL1_HUMAN:
NXNL2

NXNL1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NXNL1 (see all 214)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1140704741,2
C--17565799(+) GGCAGG/ACTTTT 1 -- int11Minor allele frequency- A:0.01WA 118
rs2007360051,2
C--17565857(+) AACAG-/CCCCCC 1 -- int10--------
rs1118217791,2
C,F--17565907(+) TCCGCC/TGGGGC 1 -- int11Minor allele frequency- T:0.23NA 120
rs1146337941,2
F--17566232(+) CTCAGC/GCTTCA 1 -- spd11Minor allele frequency- G:0.05WA 118
rs1833714941,2
--17566273(+) CACCGA/GGCTAA 1 -- ut310--------
rs1877768731,2
--17566357(+) CTCCCA/GCCTTG 1 -- ut310--------
rs563842971,2
C--17566409(+) TGGGGG/TTGGAG 1 -- ut313Minor allele frequency- T:0.23NA CSA 123
rs560845151,2
C--17566562(+) ACTCGG/ATGAGG 2 /T /I mis11Minor allele frequency- A:0.50NA 2
rs2016241691,2
--17566574(+) TCCGTA/GGCTCC 2 P L mis10--------
rs2011590271,2
--17566605(+) CAGCTG/TGAAGT 2 K Q mis10--------

HapMap Linkage Disequilibrium report for NXNL1 (17566234 - 17571763 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for NXNL1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv911182CNV Loss21882294
dgv3761n71CNV Loss21882294
nsv911205CNV Loss21882294
nsv833768CNV Loss17160897
nsv911203CNV Loss21882294

Human Gene Mutation Database (HGMD): NXNL1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NXNL1
DNA2.0 Custom Variant and Variant Library Synthesis for NXNL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608791    OMIM disorders: --

7 diseases for NXNL1:    About MalaCards
cone dystrophy    bardet-biedl syndrome    leber congenital amaurosis    blindness
retinitis pigmentosa    retinal degeneration    retinitis

1 disease from the University of Copenhagen DISEASES database for NXNL1:
Retinitis pigmentosa

NXNL1 for disorders           About GeneDecksing

2 Novoseek inferred disease relationships for NXNL1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
retinitis pigmentosa 82.9 7 19843539 (4), 15639013 (1), 19277021 (1)
blindness 46.3 3 19843539 (2)

Genetic Association Database (GAD): NXNL1
Human Genome Epidemiology (HuGE) Navigator: NXNL1 (1 document)

Export disorders for NXNL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NXNL1 gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with NXNL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population. (PubMed id 19402160)1, 4 Bin J....HAcon E. (Hum. Mutat. 2009)
  2. Mapping of transcription start sites of human retina expressed genes. (PubMed id 17286855)1, 2 Roni V.... Wissinger B. (BMC Genomics 2007)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Thioredoxin-like 6 protects retinal cell line from photooxidative damage by upregulating NF-kappaB activity. (PubMed id 18474255)1, 9 Wang X.W....Ding J.L. (amp 2008)
  5. The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina. (PubMed id 19843539)1, 9 Reichman S....LAcveillard T. (Hum. Mol. Genet. 2010)
  6. Identification and characterization of rod-derived cone viability factor. (PubMed id 15220920)1, 9 LAcveillard T....Sahel J.A. (Nat. Genet. 2004)
  7. Disease-associated variants of the rod-derived cone viability factor (RdCVF) in Leber congenital amaurosis. Rod-derived cone viability variants in LCA. (PubMed id 17249548)1, 9 Hanein S....Leveillard T. (Adv. Exp. Med. Biol. 2006)
  8. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
  9. TXNL6 is a novel oxidative stress-induced reducing system for methionine sulfoxide reductase a repair of I+-crystallin and cytochrome C in the eye lens. (PubMed id 21079812)1 Brennan L.A....Kantorow M. (PLoS ONE 2010)
  10. Expression of rod-derived cone viability factor: dual role of CRX in regulating promoter activity and cell-type specificity. (PubMed id 20949100)1 Lambard S....Zack D.J. (PLoS ONE 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 115861 HGNC: 25179 AceView: TXNL6 Ensembl:ENSG00000171773 euGenes: HUgn115861
ECgene: NXNL1 H-InvDB: NXNL1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NXNL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NXNL1 gene:
Search GeneIP for patents involving NXNL1

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NXNL1  
 OriGene qPCR primer pairs and template standards for NXNL1   OriGene Protein Over-expression Lysate for NXNL1  
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 Block miRNA regulation of human, mouse, rat NXNL1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NXNL1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NXNL1 Predesigned siRNA for gene silencing in human, mouse, rat NXNL1
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 Novus Tissue Slides
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 Browse ESI BIO Cell Lines and PureStem Progenitors for NXNL1
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXNL1
 SwitchGear 3'UTR luciferase reporter plasmids for NXNL1
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 Search ThermoFisher Antibodies for NXNL1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXNL1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NXNL1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NXNL1
 LSBio Antibodies in human, mouse, rat for NXNL1
Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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