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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXN Gene

protein-coding   GIFtS: 56
GCID: GC17M000702

nucleoredoxin
 Explore 5 diseases affiliated with
NXN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NXN    

Aliases
for NXN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nucleoredoxin1
NRX1 2 3
EC 1.8.1.83 8
FLJ126141
TRG-42
Nucleoredoxin 12

External Ids:    HGNC: 180081   Entrez Gene: 643592   Ensembl: ENSG000001676937   OMIM: 6128955   UniProtKB: Q6DKJ43   

Export aliases for NXN gene to outside databases

Previous GC identifers: GC17M000778 GC17M000906 GC17M000656 GC17M000687 GC17M000649 GC17M000613


Summaries
for NXN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NXN_HUMAN, Q6DKJ4
Function: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing
ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator
of protein phosphatase 2A (PP2A) (By similarity)




Genomic Views
for NXN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NXN gene promoter:
         ER-alpha   ISGF-3   STAT1   STAT1beta   MIF-1   AP-2gamma   C/EBPalpha   STAT1alpha   CHOP-10   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NXN promoter sequence
   Search SABiosciences Chromatin IP Primers for NXN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

NXN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXN gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000702:  view genomic region     (about GC identifiers)

Start:
 702,553 bp from pter      End:
 883,010 bp from pter
Size:
 180,458 bases      Orientation:
 minus strand

Proteins
for NXN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NXN_HUMAN, Q6DKJ4 (See protein sequence)
Recommended Name: Nucleoredoxin  
Size: 435 amino acids; 48392 Da
Subunit: Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts
with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress (By similarity)
Subcellular location: Cytoplasm, cytosol (By similarity). Nucleus (By similarity)
Sequence caution: Sequence=BAB14171.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB55122.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DXQ0 D3DTH2 Q3SWW6 Q6P3U6 Q7L4C6 Q9H9Q1
Alternative splicing: 3 isoforms:  Q6DKJ4-1   Q6DKJ4-2   Q6DKJ4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NXN: NX_Q6DKJ4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6DKJ4

    • 4/14 DME Specific Peptides for NXN (Q6DKJ4) (see all 14)
     VCRNGLL  EVIAGPL  DMPWLALPY  RLEIVFVSSD 

    NXN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001192248.1  NP_071908.2  

    ENSEMBL proteins: 
     ENSP00000461038   ENSP00000337443   ENSP00000461562   ENSP00000446446   ENSP00000445087  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: NXN
    OriGene Protein Over-expression Lysate: NXN
    OriGene Custom Protein Services for NXN 
    GenScript Custom Purified and Recombinant Proteins Services for NXN
    Novus Biologicals NXN Protein
    Novus Biologicals NXN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NXN

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--


    NXN for ontologies           About GeneDecksing



    NXN Antibody Products: 
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    Search for Antibodies for NXN at Abcam  
    Uscn Antibodies for NXN
    Search ThermoFisher Antibodies for NXN

    Assay Products for NXN: 
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    GenScript Custom Assay Services for NXN
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    Uscn ELISAs and CLIAs for NXN

    Protein Domains /
    Families
    for NXN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NXN for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6DKJ4

    ProtoNet protein and cluster: Q6DKJ4

    1 Blocks protein family: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: NXN_HUMAN, Q6DKJ4
    Similarity: Belongs to the nucleoredoxin family
    Similarity: Contains 1 thioredoxin domain


    Function
    for NXN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NXN_HUMAN, Q6DKJ4
    Function: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing
    ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator
    of protein phosphatase 2A (PP2A) (By similarity)
    Catalytic activity: Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H

    Enzyme Number (IUBMB): EC 1.8.1.81 2

    miRNA
    Products:            		miRTarBase miRNAs that target NXN:
    hsa-let-7b (MIRT001611)

    OriGene 3'-UTR Clone: NXN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXN
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate NXN (see all 22):
    hsa-miR-765 hsa-miR-520a-5p hsa-miR-421 hsa-miR-515-5p hsa-miR-124 hsa-miR-3150b-3p hsa-miR-298 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmid: NXN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXN (see all 7)
    OriGene shRNA RFP: NXN
    OriGene siRNA: NXN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NXN

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXN (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXN (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NXN (NM_022463)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXN 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NXN
    Search LifeMap BioReagents cell lines for NXN

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXN

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004791thioredoxin-disulfide reductase activity IEA--
    GO:0005515protein binding ----
    GO:0047134protein-disulfide reductase activity IEA--


    NXN for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NXN:
     Decreased viability with pacli 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nxn):
     cardiovascular system  cellular  craniofacial  growth/size  mortality/aging 
     skeleton 

    NXN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NXN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/14 Interacting proteins for NXN (Q6DKJ42, 3 ENSP000003374434) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEC63Q9UGP82, 3, ENSP000003579984MINT-8085420 I2D: score=1 STRING: ENSP00000357998
    USP3Q9Y6I43, ENSP000003696814I2D: score=2 STRING: ENSP00000369681
    PPP2CAP677753, ENSP000004184474I2D: score=1 STRING: ENSP00000418447
    CHMP6Q96FZ73, ENSP000003174684I2D: score=1 STRING: ENSP00000317468
    DVL2O146413I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030154cell differentiation IEA--
    GO:0030178negative regulation of Wnt receptor signaling pathway ISS--
    GO:0031397negative regulation of protein ubiquitination ISS--
    GO:0072358cardiovascular system development ISS--


    NXN for ontologies           About GeneDecksing



    Drugs & Compounds
    for NXN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXN

    1 HMDB Compound for NXN    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Search CenterWatch for drugs/clinical trials and news about NXN 

    Transcripts
    for NXN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NXN gene (2 alternative transcripts): 
    NM_001205319.1  NM_022463.4  

    Unigene Cluster for NXN:

    Nucleoredoxin
    Hs.527989  [show with all ESTs]
    Unigene Representative Sequence: NM_022463
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575801(uc010vqd.2 uc010vqe.2) ENST00000336868(uc002fsa.3)
    ENST00000571281 ENST00000571684 ENST00000537628 ENST00000574018 ENST00000575455(uc002fsb.1)
    ENST00000577098 ENST00000571338 ENST00000575171 ENST00000576991 ENST00000571080
    ENST00000538650

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NXN
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXN
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate NXN (see all 22):
    hsa-miR-765 hsa-miR-520a-5p hsa-miR-421 hsa-miR-515-5p hsa-miR-124 hsa-miR-3150b-3p hsa-miR-298 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmid: NXN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXN (see all 7)
    OriGene shRNA RFP: NXN
    OriGene siRNA: NXN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXN
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXN (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXN (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NXN (NM_022463)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXN 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NXN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXN

    Additional cDNA sequence: 

    AF086523.1 AK022676.1 AK027451.1 AK297990.1 AK302073.1 AY189690.1 BC009327.2 BC063828.1 
    BC073845.1 BC104634.1 

    13 DOTS entries:

    DT.95333153  DT.95111358  DT.100778497  DT.95111351  DT.100778498  DT.91834863  DT.92432337  DT.95111355 
    DT.100778495  DT.92432338  DT.209516  DT.95096195  DT.95183258 

    24/162 AceView cDNA sequences (see all 162):

    AI698771 BQ645151 BM726154 AA481440 BC009327 BQ029102 BE879305 AA862671 
    BE905889 BQ102360 AI143516 AI675517 BQ644962 AW118286 BU184164 BQ652275 
    AA595689 BM994912 BU526468 CR607415 BQ881624 CA433758 BM682582 AJ572471 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NXN    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                          -                             -           -                     
    SP2:                                                                                          
    SP3:              -     -     -                                                               
    SP4:        -     -     -     -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NXN

    Expression
    for NXN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGCTCACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NXN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NXN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXN

    SOURCE GeneReport for Unigene cluster: Hs.527989
        SABiosciences Custom PCR Arrays for NXN
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXN
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXN

    Orthologs
    for NXN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NXN gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NXN1 nucleoredoxin 85.29(n)
    93.02(a)    		   417619  XM_003642433.1  XP_003642481.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NXN6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL344108.1(34952-43153)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.127492 Xenopus laevis transcribed sequence with moderate similarity more 77.31(n)    BJ075549.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nxn1 nucleoredoxin 73.21(n)
    77.27(a)    		   553621  NM_001020595.1  NP_001018431.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 27(a)
    		 1 ↔ 1
    		 GroupUn.98(74242-84265)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G312406
    AT1G604206
    		 putative nucleoredoxin 1
    		 23(a)
    19(a)
    		 possible ortholog
    possible ortholog
    		 4(15176455-15178768)
    1(22261888-22264408)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 protein disulfide isomerase, putative, expressed
    (see all 4)    		 23(a)
    22(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 1(33640910-33649951)
    4(30620539-30623344)


    ENSEMBL Gene Tree for NXN (if available)
    TreeFam Gene Tree for NXN (if available) 

    Paralogs
    for NXN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXN gene
    NXNL22  NXNL12  
    1 SIMAP similar gene for NXN using alignment to 3 protein entries:     NXN_HUMAN (see all proteins):
    NXNL2

    NXN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NXN
    PGOHUM00000259516


    Genomic Variants
    for NXN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4974 NCBI SNPs in NXN are shown (see all 4974)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs732857421,2
    		C,F,--702077(+) AGGTCG/AGCCAC 2 -- ds50013Minor allele frequency- A:0.17WA CSA 122
    rs5074571,2
    		C,F,A,H,--702155(-) CCAGCA/TGGTCC 2 -- ds500113Minor allele frequency- T:0.48MN NA WA CSA EA 559
    rs2015831871,2
    		--702156(+) GACCT-/GCTGGG 2 -- ds50010--------
    rs732857451,2
    		C,F,--702206(+) GACCCG/ATGCGT 2 -- ds50017Minor allele frequency- A:0.14WA CSA NA EA 365
    rs124495441,2
    		C,H,--702404(+) ATCCAA/CATGAG 2 -- ds50014Minor allele frequency- C:0.29NA WA EA 360
    rs768324531,2
    		C,F,--702434(+) CAAGAG/AGATGT 2 -- ds50013Minor allele frequency- A:0.12NA 124
    rs759750791,2
    		--702465(+) GGTCTC/GAAAAC 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1888142011,2
    		--702519(+) ACCCCA/GATAGA 2 -- ds50010--------
    rs1816101461,2
    		--702745(+) AGCGGA/GTGGGG 2 -- ut310--------
    rs1400874981,2
    		--702829(+) TTGGCC/TGAAGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NXN (702553 - 883010 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 57 variations for NXN
         15/31 CNVs (see all 31): 77493 77490 39192 49927 77488 88302 88307 3136 88306 88303 88297 88295 77494 88301 102376
         15/26 Indels (see all 26): 11859 40159 102375 41531 77487 67100 11858 88296 11857 77492 42462 77495 88298 25911 33639
    Human Gene Mutation Database (HGMD): NXN

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXN
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    Disorders / Diseases
    for NXN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NXN for disorders           About GeneDecksing

    OMIM gene information: 612895    OMIM disorders: --

    5 diseases for NXN:    About MalaCards
    rectum adenocarcinoma    vulvitis    proctitis    bipolar disorder
    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for NXN:
    Vulvitis
    Human Genome Epidemiology (HuGE) Navigator: NXN (1 document)

    Export disorders for NXN gene to outside databases

    Publications
    for NXN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXN gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with NXN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of nucleoredoxin with protein phosphatase 2A. (PubMed id 16764867)1, 2 Lechward K....Zolnierowicz S. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. An interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver disease. (PubMed id 21251912)1 MA1ller L....Zimmermann R. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for NXN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NXN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64359 HGNC: 18008 AceView: NXN Ensembl:ENSG00000167693 euGenes: HUgn64359
    ECgene: NXN H-InvDB: NXN

    Other Databases showing NXN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NXN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NXN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NXN gene:
    Search GeneIP for patents involving NXN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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