External Ids for NXN Gene
Previous GeneCards Identifiers for NXN Gene
GeneCards Summary for NXN Gene
NXN (Nucleoredoxin) is a Protein Coding gene. Diseases associated with NXN include vulvitis and polycystic liver disease. GO annotations related to this gene include thioredoxin-disulfide reductase activity and protein-disulfide reductase activity. An important paralog of this gene is NXNL1.
UniProtKB/Swiss-Prot for NXN Gene
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).