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Aliases for NXN Gene

Aliases for NXN Gene

  • Nucleoredoxin 2 3 5
  • EC 4 63
  • NRX 3 4
  • Nucleoredoxin 1 3
  • TRG-4 3

External Ids for NXN Gene

Previous GeneCards Identifiers for NXN Gene

  • GC17M000778
  • GC17M000906
  • GC17M000656
  • GC17M000687
  • GC17M000649
  • GC17M000702
  • GC17M000613

Summaries for NXN Gene

Entrez Gene Summary for NXN Gene

  • This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]

GeneCards Summary for NXN Gene

NXN (Nucleoredoxin) is a Protein Coding gene. Diseases associated with NXN include Vulvitis and Vulvar Disease. GO annotations related to this gene include oxidoreductase activity and thioredoxin-disulfide reductase activity. An important paralog of this gene is NXNL1.

UniProtKB/Swiss-Prot for NXN Gene

  • Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXN Gene

Genomics for NXN Gene

Regulatory Elements for NXN Gene

Enhancers for NXN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NXN on UCSC Golden Path with GeneCards custom track

Promoters for NXN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NXN on UCSC Golden Path with GeneCards custom track

Genomic Location for NXN Gene

799,313 bp from pter
979,770 bp from pter
180,458 bases
Minus strand

Genomic View for NXN Gene

Genes around NXN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXN Gene

Proteins for NXN Gene

  • Protein details for NXN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B4DXQ0
    • D3DTH2
    • Q3SWW6
    • Q6P3U6
    • Q7L4C6
    • Q9H9Q1

    Protein attributes for NXN Gene

    435 amino acids
    Molecular mass:
    48392 Da
    Quaternary structure:
    • Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress (By similarity).
    • Sequence=BAB14171.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55122.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NXN Gene


neXtProt entry for NXN Gene

Proteomics data for NXN Gene at MOPED

Post-translational modifications for NXN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXN Gene

Domains & Families for NXN Gene

Protein Domains for NXN Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Belongs to the nucleoredoxin family.
  • Contains 1 thioredoxin domain.
  • Belongs to the nucleoredoxin family.
genes like me logo Genes that share domains with NXN: view

No data available for Gene Families for NXN Gene

Function for NXN Gene

Molecular function for NXN Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).

Enzyme Numbers (IUBMB) for NXN Gene

genes like me logo Genes that share phenotypes with NXN: view

Animal Models for NXN Gene

MGI Knock Outs for NXN:
  • Nxn tm1Hmik
  • Nxn tm1b(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for NXN

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXN Gene

Localization for NXN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXN Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

Jensen Localization Image for NXN Gene COMPARTMENTS Subcellular localization image for NXN gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for NXN Gene

Pathways & Interactions for NXN Gene

SuperPathways for NXN Gene

No Data Available

Gene Ontology (GO) - Biological Process for NXN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
GO:0030178 negative regulation of Wnt signaling pathway IEA,ISS --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with NXN: view

No data available for Pathways by source and SIGNOR curated interactions for NXN Gene

Drugs & Compounds for NXN Gene

(1) Drugs for NXN Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NAD Pharma Full agonist, Agonist 0
genes like me logo Genes that share compounds with NXN: view

Transcripts for NXN Gene

Unigene Clusters for NXN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXN Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - - -
SP3: - - -
SP4: - - - -

Relevant External Links for NXN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXN Gene

mRNA expression in normal human tissues for NXN Gene

mRNA differential expression in normal tissues according to GTEx for NXN Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for NXN Gene

This gene is overexpressed in Cervix (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NXN Gene

SOURCE GeneReport for Unigene cluster for NXN Gene Hs.527989

genes like me logo Genes that share expression patterns with NXN: view

Protein tissue co-expression partners for NXN Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NXN Gene

Orthologs for NXN Gene

This gene was present in the common ancestor of animals.

Orthologs for NXN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NXN 35
  • 93.79 (n)
  • 97.7 (a)
NXN 36
  • 97 (a)
(Canis familiaris)
Mammalia NXN 35
  • 93.18 (n)
  • 98.16 (a)
NXN 36
  • 95 (a)
(Mus musculus)
Mammalia Nxn 35
  • 91.8 (n)
  • 97.93 (a)
Nxn 16
Nxn 36
  • 98 (a)
(Pan troglodytes)
Mammalia NXN 35
  • 99.31 (n)
  • 99.77 (a)
NXN 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nxn 35
  • 91.15 (n)
  • 97.83 (a)
(Monodelphis domestica)
Mammalia NXN 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia NXN 36
  • 91 (a)
(Gallus gallus)
Aves NXN 35
  • 85.63 (n)
  • 93.12 (a)
NXN 36
  • 90 (a)
(Anolis carolinensis)
Reptilia NXN 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nxn 35
  • 74.96 (n)
  • 83.17 (a)
Str.10653 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12749 35
(Danio rerio)
Actinopterygii nxn 35
  • 73.21 (n)
  • 77.27 (a)
nxn 36
  • 78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2967 35
(Caenorhabditis elegans)
Secernentea C30H6.8 36
  • 24 (a)
C32D5.8 36
  • 33 (a)
C35B1.5 36
  • 29 (a)
F17B5.1 36
  • 6 (a)
F29B9.5 36
  • 30 (a)
R05H5.3 36
  • 31 (a)
T05F1.11 36
  • 7 (a)
T20D4.7 36
  • 35 (a)
T28A11.13 36
  • 38 (a)
trx-3 36
  • 24 (a)
trx-5 36
  • 35 (a)
Y52E8A.3 36
  • 33 (a)
Species with no ortholog for NXN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXN Gene

Gene Tree for NXN (if available)
Gene Tree for NXN (if available)

Paralogs for NXN Gene

Paralogs for NXN Gene

(1) SIMAP similar genes for NXN Gene using alignment to 3 proteins: Pseudogenes for NXN Gene

genes like me logo Genes that share paralogs with NXN: view

Variants for NXN Gene

Sequence variations from dbSNP and Humsavar for NXN Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2114 -- 896,607(-) AAACA(C/T)GAAGA intron-variant
rs2115 -- 896,557(-) CAACA(A/G/T)GGAGA intron-variant
rs14637 -- 799,502(+) ATTAG(C/T)GGGTG utr-variant-3-prime
rs168000 -- 970,868(-) TCCAA(A/C)GAACT intron-variant
rs474176 -- 901,187(+) AAGTG(A/C)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXN Gene

Variant ID Type Subtype PubMed ID
esv2422420 CNV Duplication 17116639
nsv457631 CNV Gain 19166990
nsv469891 CNV Complex 16826518
dgv925e1 CNV Complex 17122850
esv673 CNV CNV 17122850
nsv907457 CNV Loss 21882294
nsv907458 CNV Gain 21882294
esv35056 CNV Gain 17911159
nsv817749 CNV Gain 17921354
nsv509643 CNV Insertion 20534489
esv2675441 CNV Deletion 23128226
nsv907459 CNV Gain 21882294
nsv907460 CNV Gain 21882294
esv2715364 CNV Deletion 23290073
nsv9486 CNV Loss 18304495
esv2715365 CNV Deletion 23290073
esv24100 CNV Loss 19812545
esv1653674 CNV Insertion 17803354
esv1062480 CNV Insertion 17803354
esv1751565 CNV Insertion 17803354
esv990845 CNV Deletion 20482838
esv2715366 CNV Deletion 23290073
esv2715367 CNV Deletion 23290073
esv2715368 CNV Deletion 23290073
dgv172n21 CNV Gain 19592680
esv2652373 CNV Deletion 19546169
esv2715369 CNV Deletion 23290073
esv1468501 CNV Deletion 17803354
esv26221 CNV Loss 19812545
nsv820321 CNV Deletion 20802225
nsv457633 CNV Loss 19166990
dgv3019n71 CNV Gain 21882294
esv270880 CNV Insertion 20981092
esv2751769 CNV Gain 17911159
esv2187086 CNV Deletion 18987734
nsv112227 CNV Loss 16902084
nsv111968 CNV Loss 16902084
esv1000293 CNV Deletion 20482838
esv1262780 CNV Deletion 17803354
esv2715370 CNV Deletion 23290073
esv2551425 CNV Insertion 19546169
esv2715371 CNV Deletion 23290073
esv1421971 CNV Insertion 17803354
esv3986 CNV Deletion 18987735
esv1130070 CNV Deletion 17803354
esv2715372 CNV Deletion 23290073
esv2715373 CNV Deletion 23290073
nsv469582 CNV Complex 16826518
essv3392 CNV CNV 17122850
nsv517783 CNV Gain 19592680
esv1296417 CNV Insertion 17803354
esv2715375 CNV Deletion 23290073
esv2666176 CNV Deletion 23128226
esv2715376 CNV Deletion 23290073
esv1781837 CNV Insertion 17803354
esv2715377 CNV Deletion 23290073
esv2715378 CNV Deletion 23290073
esv2522999 CNV Deletion 19546169
esv2715379 CNV Deletion 23290073
dgv431e201 CNV Deletion 23290073
esv2715381 CNV Deletion 23290073
nsv112186 CNV Loss 16902084
esv1098416 CNV Deletion 17803354
esv2715383 CNV Deletion 23290073
esv2715384 CNV Deletion 23290073
dgv3020n71 CNV Gain 21882294
nsv907465 CNV Loss 21882294
nsv512463 CNV Loss 21212237
esv2445764 CNV Deletion 19546169
esv3732 CNV Deletion 18987735
esv2675496 CNV Deletion 23128226
nsv112140 CNV Loss 16902084
esv2715386 CNV Deletion 23290073
nsv907467 CNV Gain 21882294
nsv112506 CNV Loss 16902084
esv2715387 CNV Deletion 23290073
esv4552 CNV Deletion 18987735
esv997618 CNV Deletion 20482838
esv1608317 CNV Deletion 17803354
nsv112448 CNV Loss 16902084
nsv112116 CNV Insertion 16902084
esv2661899 CNV Deletion 23128226
nsv521627 CNV Gain 19592680
nsv907468 CNV Loss 21882294
nsv907469 CNV Gain 21882294
esv29359 CNV Gain+Loss 19812545
esv2715388 CNV Deletion 23290073
esv1228868 CNV Deletion 17803354
esv1758019 CNV Deletion 17803354
esv1681339 CNV Deletion 17803354
esv2715389 CNV Deletion 23290073
dgv432e201 CNV Deletion 23290073
dgv433e201 CNV Deletion 23290073
dgv3021n71 CNV Loss 21882294
dgv3022n71 CNV Loss 21882294
esv24016 CNV Loss 19812545
esv2715391 CNV Deletion 23290073
essv8 CNV CNV 17122850
nsv827852 CNV Gain 20364138
esv2715392 CNV Deletion 23290073
esv2715393 CNV Deletion 23290073
esv1008136 CNV Loss 20482838
esv2715394 CNV Deletion 23290073
esv27012 CNV Gain+Loss 19812545
esv2715395 CNV Deletion 23290073
esv1316976 CNV Insertion 17803354
nsv907472 CNV Loss 21882294
dgv3023n71 CNV Loss 21882294
dgv3024n71 CNV Loss 21882294

Variation tolerance for NXN Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXN Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXN Gene

Disorders for NXN Gene

MalaCards: The human disease database

(3) MalaCards diseases for NXN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vulvar disease
  • vulvar diseases
polycystic liver disease
  • isolated autosomal dominant polycystic liver disease
- elite association - COSMIC cancer census association via MalaCards
Search NXN in MalaCards View complete list of genes associated with diseases

Relevant External Links for NXN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NXN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXN Gene

Publications for NXN Gene

  1. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PMID: 19308021) Ollila H.M. … Paunio T. (Mol. Psychiatry 2009) 3 48 67
  2. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. (PMID: 24836286) Zhang B. … Zheng W. (Nat. Genet. 2014) 3
  5. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3

Products for NXN Gene

Sources for NXN Gene