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NXN Gene

protein-coding   GIFtS: 57
GCID: GC17M000702

Nucleoredoxin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
nucleoredoxin1 2
NRX2 3
EC 1.8.1.83 8
TRG-42
Nucleoredoxin 12

External Ids:    HGNC: 180081   Entrez Gene: 643592   Ensembl: ENSG000001676937   OMIM: 6128955   UniProtKB: Q6DKJ43   

Export aliases for NXN gene to outside databases

Previous GC identifers: GC17M000778 GC17M000906 GC17M000656 GC17M000687 GC17M000649 GC17M000613


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NXN Gene:
NXN (nucleoredoxin) is a protein-coding gene. Diseases associated with NXN include rectum adenocarcinoma, and vulvitis. GO annotations related to this gene include thioredoxin-disulfide reductase activity and protein-disulfide reductase activity. An important paralog of this gene is NXNL2.

UniProtKB/Swiss-Prot: NXN_HUMAN, Q6DKJ4
Function: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing
ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a
regulator of protein phosphatase 2A (PP2A) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  NT_187613.1  NT_187664.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the NXN gene promoter:
         ER-alpha   ISGF-3   STAT1   STAT1beta   MIF-1   AP-2gamma   C/EBPalpha   STAT1alpha   CHOP-10   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXN promoter sequence
   Search Chromatin IP Primers for NXN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NXN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13

NXN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXN gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000702:  view genomic region     (about GC identifiers)

Start:
702,553 bp from pter      End:
883,010 bp from pter
Size:
180,458 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NXN_HUMAN, Q6DKJ4 (See protein sequence)
Recommended Name: Nucleoredoxin  
Size: 435 amino acids; 48392 Da
Subunit: Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct.
Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress (By similarity)
Sequence caution: Sequence=BAB14171.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB55122.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DXQ0 D3DTH2 Q3SWW6 Q6P3U6 Q7L4C6 Q9H9Q1
Alternative splicing: 3 isoforms:  Q6DKJ4-1   Q6DKJ4-2   Q6DKJ4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NXN: NX_Q6DKJ4

Explore proteomics data for NXN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NXN (Q6DKJ4) (see all 14)
     VCRNGLL  EVIAGPL  DMPWLALPY  RLEIVFVSSD 


    See NXN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001192248.1  NP_071908.2  

    ENSEMBL proteins: 
     ENSP00000461038   ENSP00000337443   ENSP00000461562   ENSP00000446446   ENSP00000445087  

    NXN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NXN
    OriGene Protein Over-expression Lysate for NXN
    OriGene MassSpec for NXN
    OriGene Custom Protein Services for NXN
    GenScript Custom Purified and Recombinant Proteins Services for NXN
    Novus Biologicals NXN Protein
    Novus Biologicals NXN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NXN

    NXN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NXN (Nucleoredoxin)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NXN
    Novus Biologicals NXN Antibodies
    Abcam antibodies for NXN
    Cloud-Clone Corp. Antibodies for NXN
    Search ThermoFisher Antibodies for NXN
    LSBio Antibodies in human, mouse, rat for NXN

    NXN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NXN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NXN
    Cloud-Clone Corp. CLIAs for NXN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6DKJ4

    ProtoNet protein and cluster: Q6DKJ4

    1 Blocks protein domain: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: NXN_HUMAN, Q6DKJ4
    Similarity: Belongs to the nucleoredoxin family
    Similarity: Contains 1 thioredoxin domain


    NXN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXN_HUMAN, Q6DKJ4
    Function: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing
    ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a
    regulator of protein phosphatase 2A (PP2A) (By similarity)
    Catalytic activity: Protein dithiol + NAD(P)(+) = protein disulfide + NAD(P)H

         Enzyme Number (IUBMB): EC 1.8.1.81 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004791thioredoxin-disulfide reductase activity IEA--
    GO:0005515protein binding ----
    GO:0016209antioxidant activity ----
    GO:0016491oxidoreductase activity ----
    GO:0047134protein-disulfide reductase activity IEA--
         
    NXN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NXN:
     Decreased viability with pacli 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nxn):
     cardiovascular system  cellular  craniofacial  growth/size/body  mortality/aging 
     skeleton 

    NXN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NXN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NXN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NXN

    miRNA
    Products:
        
    miRTarBase miRNAs that target NXN:
    hsa-mir-92a-3p (MIRT049102), hsa-mir-124-3p (MIRT022572), hsa-mir-652-3p (MIRT039562), hsa-mir-1 (MIRT023721), hsa-mir-186-5p (MIRT045235), hsa-let-7b-5p (MIRT001611)

    Block miRNA regulation of human, mouse, rat NXN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NXN (see all 22):
    hsa-miR-765 hsa-miR-520a-5p hsa-miR-421 hsa-miR-515-5p hsa-miR-124 hsa-miR-3150b-3p hsa-miR-298 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidNXN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NXN
    Predesigned siRNA for gene silencing in human, mouse, rat NXN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NXN

    Clone
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    OriGene clones in human, mouse for NXN (see all 7)
    OriGene ORF clones in mouse, rat for NXN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NXN (NM_022463)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NXN
    Browse ESI BIO Cell Lines and PureStem Progenitors for NXN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NXN_HUMAN, Q6DKJ4: Cytoplasm, cytosol (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    golgi apparatus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    NXN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NXN
    Interactions:

        Search GeneGlobe Interaction Network for NXN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for NXN (Q6DKJ42, 3 ENSP000003374434) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEC63Q9UGP82, 3, ENSP000003579984MINT-8085420 I2D: score=1 STRING: ENSP00000357998
    USP3Q9Y6I43, ENSP000003696814I2D: score=2 STRING: ENSP00000369681
    PPP2CAP677753, ENSP000004184474I2D: score=1 STRING: ENSP00000418447
    CHMP6Q96FZ73, ENSP000003174684I2D: score=1 STRING: ENSP00000317468
    DVL2O146413I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt signaling pathway IEA--
    GO:0030154cell differentiation IEA--
    GO:0030178negative regulation of Wnt signaling pathway ISS--
    GO:0031397negative regulation of protein ubiquitination ISS--
    GO:0045454cell redox homeostasis ----

    NXN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NXN

    1 HMDB Compound for NXN    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NXN gene (2 alternative transcripts): 
    NM_001205319.1  NM_022463.4  

    Unigene Cluster for NXN:

    Nucleoredoxin
    Hs.527989  [show with all ESTs]
    Unigene Representative Sequence: NM_022463
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575801(uc010vqd.2 uc010vqe.2) ENST00000336868(uc002fsa.3)
    ENST00000571281 ENST00000571684 ENST00000537628 ENST00000574018 ENST00000575455(uc002fsb.1)
    ENST00000577098 ENST00000571338 ENST00000575171 ENST00000576991 ENST00000571080
    ENST00000538650
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NXN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NXN (see all 22):
    hsa-miR-765 hsa-miR-520a-5p hsa-miR-421 hsa-miR-515-5p hsa-miR-124 hsa-miR-3150b-3p hsa-miR-298 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidNXN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NXN
    Predesigned siRNA for gene silencing in human, mouse, rat NXN
    Clone
    Products:
         
    OriGene clones in human, mouse for NXN (see all 7)
    OriGene ORF clones in mouse, rat for NXN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NXN (NM_022463)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NXN
    OriGene qSTAR qPCR primer pairs in human, mouse for NXN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXN
      QuantiTect SYBR Green Assays in human, mouse, rat NXN
      QuantiFast Probe-based Assays in human, mouse, rat NXN

    Additional mRNA sequence: 

    AF086523.1 AK022676.1 AK027451.1 AK297990.1 AK302073.1 AY189690.1 BC009327.2 BC063828.1 
    BC073845.1 BC104634.1 

    13 DOTS entries:

    DT.95333153  DT.95111358  DT.100778497  DT.95111351  DT.100778498  DT.91834863  DT.92432337  DT.95111355 
    DT.100778495  DT.92432338  DT.209516  DT.95096195  DT.95183258 

    Selected AceView cDNA sequences (see all 162):

    AI698771 BC009327 BE879305 AA481440 AA862671 BQ644962 BQ102360 AI143516 
    BE905889 BU184164 AI675517 AW118286 AA595689 BQ652275 BU526468 BQ881624 
    BM994912 CR607415 BQ645151 BQ029102 BM726154 AJ572471 BM682582 BE018926 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NXN    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b
    SP1:                          -                             -           -                     
    SP2:                                                                                          
    SP3:              -     -     -                                                               
    SP4:        -     -     -     -                                                               
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NXN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NXN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCTCACA
    NXN Expression
    About this image


    NXN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem cells
    NXN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NXN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.527989
        Custom PCR Arrays for NXN
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NXN
    OriGene qSTAR qPCR primer pairs in human, mouse for NXN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NXN
    QuantiTect SYBR Green Assays in human, mouse, rat NXN
    QuantiFast Probe-based Assays in human, mouse, rat NXN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NXN gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxn1 , 5 nucleoredoxin1, 5 91.8(n)1
    97.93(a)1
      11 (45.92 cM)5
    182301  NM_008750.51  NP_032776.11 
     762571985 
    chicken
    (Gallus gallus)
    Aves NXN1 nucleoredoxin 85.63(n)
    93.12(a)
      417619  XM_003642433.2  XP_003642481.2 
    lizard
    (Anolis carolinensis)
    Reptilia NXN6
    nucleoredoxin
    88(a)
    1 ↔ 1
    GL344108.1(34952-47091)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.127492 Xenopus laevis transcribed sequence with moderate similarity more 77.31(n)    BJ075549.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nxn1 nucleoredoxin 73.21(n)
    77.27(a)
      553621  NM_001020595.1  NP_001018431.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T05F1.116
    F17B5.16
    (see all 12)
    Protein T05F1.11 (T05F1.11) mRNA, complete cds
    Protein F17B5.1, isoform a (F17B5.1) mRNA, complet...
    (see all 12)
    7(a)
    6(a)
    (see all 12)
    many ↔ many
    many ↔ many
    (see all 12)
    I(9653101-9657040) WBGene00011495
    I(13184912-13188297) WBGene00008905


    ENSEMBL Gene Tree for NXN (if available)
    TreeFam Gene Tree for NXN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NXN gene
    NXNL22  NXNL12  
    1 SIMAP similar gene for NXN using alignment to 3 protein entries:     NXN_HUMAN (see all proteins):
    NXNL2

    NXN for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NXN
    PGOHUM00000259516


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NXN (see all 5718)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732857421,2
    C,F--702077(+) AGGTCG/AGCCAC 2 -- ds50013Minor allele frequency- A:0.17WA CSA 122
    rs5074571,2
    C,F,A,H--702155(-) CCAGCA/TGGTCC 2 -- ds500113Minor allele frequency- T:0.48MN NA WA CSA EA 559
    rs2015831871,2
    --702156(+) GACCT-/GCTGGG 2 -- ds50010--------
    rs732857451,2
    C,F--702206(+) GACCCG/ATGCGT 2 -- ds50017Minor allele frequency- A:0.14WA CSA NA EA 365
    rs124495441,2
    C,H--702404(+) ATCCAA/CATGAG 2 -- ds50014Minor allele frequency- C:0.29NA WA EA 360
    rs768324531,2
    C,F--702434(+) CAAGAG/AGATGT 2 -- ds50013Minor allele frequency- A:0.12NA 124
    rs759750791,2
    F--702465(+) GGTCTC/GAAAAC 2 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1888142011,2
    --702519(+) ACCCCA/GATAGA 2 -- ds50010--------
    rs1816101461,2
    --702745(+) AGCGGA/GTGGGG 2 -- ut310--------
    rs1400874981,2
    --702829(+) TTGGCC/TGAAGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NXN (702553 - 883010 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NXN (see all 109):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2522999CNV Deletion19546169
    esv2715389CNV Deletion23290073
    esv2715384CNV Deletion23290073
    esv1130070CNV Deletion17803354
    esv1228868CNV Deletion17803354
    esv3986CNV Deletion18987735
    esv2715391CNV Deletion23290073
    esv1468501CNV Deletion17803354
    dgv433e201CNV Deletion23290073
    esv997618CNV Deletion20482838

    Human Gene Mutation Database (HGMD): NXN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NXN
    DNA2.0 Custom Variant and Variant Library Synthesis for NXN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612895    OMIM disorders: --

    9 diseases for NXN:    
    About MalaCards
    rectum adenocarcinoma    vulvitis    polycystic liver disease    proctitis
    liver disease    bipolar disorder    adenocarcinoma    prostate cancer
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for NXN:
    Vulvitis

    NXN for disorders           About GeneDecksing

    Genetic Association Database (GAD): NXN
    Human Genome Epidemiology (HuGE) Navigator: NXN (1 document)

    Export disorders for NXN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NXN gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with NXN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)1, 4 Ollila H.M....Paunio T. (Mol. Psychiatry 2009)
    2. Interaction of nucleoredoxin with protein phosphatase 2A. (PubMed id 16764867)1, 2 Lechward K....Zolnierowicz S. (FEBS Lett. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. (PubMed id 23300278)1 Saxena R....Sanghera D.K. (Diabetes 2013)
    5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (Nat. Genet. 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. The genetic architecture of economic and political preferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 64359 HGNC: 18008 AceView: NXN Ensembl:ENSG00000167693 euGenes: HUgn64359
    ECgene: NXN H-InvDB: NXN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NXN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NXN gene:
    Search GeneIP for patents involving NXN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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