External Ids for NXF5 Gene
Previous GeneCards Identifiers for NXF5 Gene
This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Alternatively spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Jul 2009]
GeneCards Summary for NXF5 Gene
NXF5 (Nuclear RNA Export Factor 5) is a Protein Coding gene. Diseases associated with NXF5 include non-syndromic x-linked intellectual disability. Among its related pathways are RNA transport and mRNA surveillance pathway. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is NXF2.
UniProtKB/Swiss-Prot for NXF5 Gene
Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.