NXF5 Gene
protein-coding GIFtS: 51
GCID: GC0XM101087
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|
nuclear RNA export factor 5
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Aliases
for NXF5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Nuclear RNA Export Factor 51 2 | | TAPL-12 3 | | TAP-Like Protein 12 3 | | TAPL13 |
| External Ids: | HGNC: 80751 | Entrez Gene: 559982 | Ensembl: ENSG000001269527 | OMIM: 3003195 | UniProtKB: Q9H1B43 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n408139 | |
Export aliases for NXF5 gene to outside databasesPrevious GC identifers: GC0XM096378 GC0XM098028 GC0XM099122 GC0XM099858 GC0XM100893 GC0XM100973 GC0XM090894
Summaries
for NXF5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NXF5:
This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and isimplicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in otherfamily members that are required for export activity, and may be an evolving pseudogene. Alternatively splicedtranscript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not expressproteins in vivo. (provided by RefSeq, Jul 2009)
UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4Function: Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role inpolarized cytoplasmic transport and localization of mRNA in neurons
|
Genomic Views
for NXF5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NXF5
Other transcription factors
Search SABiosciences Chromatin IP Primers for NXF5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22NXF5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM101087: view genomic region
(about GC identifiers)
Start:
|
101,087,085 bp from pter |
End:
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101,112,549 bp from pter |
Size:
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25,465 bases |
Orientation:
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minus strand |
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Proteins
for NXF5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4 (See
protein sequence)Recommended Name: Nuclear RNA export factor 5 Size: 397 amino acids; 45628 Da
Subunit: Interacts with NXT1 and NXT2
Subcellular location: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in thecell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclearrim
Secondary accessions: A2RRM0 B1AV82 B1AV83 B1AV84 B1AV85 Q9H1B0 Q9H1B1 Q9H1B2 Q9H1B3Alternative splicing: 6 isoforms: Q9H1B4-1 Q9H1B4-2 Q9H1B4-3 Q9H1B4-4 Q9H1B4-5 Q9H1B4-6 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for NXF5: NX_Q9H1B4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1B4
NXF5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116564.2
ENSEMBL proteins: ENSP00000263032 ENSP00000361889 ENSP00000422976 ENSP00000354539 ENSP00000331535 ENSP00000426978 ENSP00000442401 ENSP00000355286
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NXF5 for ontologies About GeneDecksing
NXF5 Antibody Products:
Assay Products for NXF5: |
Protein
Domains /
Families
for NXF5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NXF5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H1B4ProtoNet protein and cluster: Q9H1B4 1 Blocks protein family: IPB002075 Nuclear transport factor 2 (NTF2)
UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4Domain: The NTF2 domain heterodimerizes with NXT1 and NXT2 (By similarity)Domain: The RNA-binding domain is a non-canonical RNP-type domainSimilarity: Belongs to the NXF familySimilarity: Contains 4 LRR (leucine-rich) repeatsSimilarity: Contains 1 NTF2 domainSimilarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for NXF5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4Function: Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role inpolarized cytoplasmic transport and localization of mRNA in neurons
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF5 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NXF5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NXF5:
|
Pathways & Interactions
for NXF5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA surveillance pathway | | | 2 | Ribosome biogenesis in eukaryotes | | | 3 | RNA transport | | | 4 | Measles | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Kegg Pathways (Kegg details for NXF5):
NXF5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXF5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/11 Interacting proteins for NXF5 (ENSP000002630324) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
NXF5 for ontologies About GeneDecksing
|
Drugs & Compounds
for NXF5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NXF5
Search CenterWatch for drugs/clinical trials and news about NXF5
|
Transcripts
for NXF5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NXF5 gene (5 alternative transcripts): NM_032946.2 NM_033152.1 NM_033153.1 NM_033154.1 NM_033155.1 Unigene Cluster for NXF5: Nuclear RNA export factor 5 Hs.307077 Unigene Representative Sequence: AJ2776548 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263032(uc004eih.1) ENST00000372803(uc004eij.1) ENST00000493509(uc004eii.1)
ENST00000361330(uc004eik.1) ENST00000332614(uc004eil.1) ENST00000473265
ENST00000537026(uc011mrk.1) ENST00000361708
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXF5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXF5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NXF5 (NM_032946) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXF5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF5 |
Additional cDNA sequence: AJ277654.1 AJ277655.1 AJ277656.1 AJ277657.1 AJ277658.1 BC131708.1 NR_028089.1 1 DOTS entry: DT.91758145 10 AceView cDNA sequences: NM_033152 NM_033154 AJ277657 AJ277656 AJ277658 NM_033155 NM_033153 NM_032946 AJ277654 AJ277655
GeneLoc Exon Structure
|
Expression
for NXF5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NXF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NXF5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NXF5
SOURCE GeneReport for Unigene cluster: Hs.307077
SABiosciences Custom PCR Arrays for NXF5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXF5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NXF5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF5 |
Orthologs
for NXF5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NXF5 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for NXF5 (if available)
TreeFam Gene Tree for NXF5 (if available) |
Paralogs
for NXF5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NXF5 gene
- NXF12 NXF32 NXF2B2 NXF22
4 SIMAP similar genes for NXF5 using alignment to 2 protein entries: NXF5_HUMAN (see all proteins):NXF2B NXF2 NXF1 NXF3
NXF5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NXF5
PGOHUM00000241917
|
Genomic Variants
for NXF5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NXF5 (101087085 - 101112549 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NXF5: --
Human Gene Mutation Database (HGMD): NXF5
Locus Specific Mutation Databases (LSDB): NXF5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXF5 |
|
Disorders
/ Diseases
for NXF5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NXF5 for disorders About GeneDecksing
OMIM gene information: 300319
OMIM disorders: --
UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4
Note=A chromosomal aberration involving NXF5 has been observed in one patient with a syndromic form of mentalretardation and short stature. Pericentric inversion inv(X)(p21.1;q22) that interrupts NXF5
6  diseases for NXF5: About MalaCardspelizaeus-merzbacher disease premature ovarian failure short stature intellectual disability
influenza neuronitis
1 disease from the University of Copenhagen DISEASES database for NXF5:Premature ovarian failure Export disorders for NXF5 gene to outside databases
|
Publications
for NXF5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NXF5 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with NXF5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. (PubMed id 11566096)1, 2, 3, 9 Jun L.... Froyen G. (2001)
- An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
- Inv(X)(p21.1;q22.1) in a man with mental retardation, short stature, general muscle wasting, and facial dysmorphism: clinical study and mutation analysis of the NXF5 gene. (PubMed id 12784308)1, 9 Frints S.G....Froyen G. (2003)
- A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PubMed id 19377476)1 Tarpey P.S.... Stratton M.R. (2009)
- Formation of a Tap/NXF1 Homotypic Complex Is Mediated through the Amino-Terminal Domain of Tap and Enhances Interaction with Nucleoporins. (PubMed id 17978099)1 Matzat L.H....Levesque L. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PubMed id 11073998)1 Herold A.... Izaurralde E. (2000)
|
External Searches for NXF5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NXF5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NXF5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NXF5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NXF5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NXF5 gene:
Search GeneIP for patents involving NXF5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NXF5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | NXF5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF5 |
|  |  |  | | | | Search ThermoFisher Antibodies for NXF5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF5 |
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