Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXF5 Gene

protein-coding   GIFtS: 51
GCID: GC0XM101087

Nuclear RNA Export Factor 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nuclear RNA Export Factor 51 2
TAPL-12 3
TAP-Like Protein 12 3
TAPL13

External Ids:    HGNC: 80751   Entrez Gene: 559982   Ensembl: ENSG000001269527   OMIM: 3003195   UniProtKB: Q9H1B43   
ORGUL members:         
NONCODE14:n408139      

Export aliases for NXF5 gene to outside databases

Previous GC identifers: GC0XM096378 GC0XM098028 GC0XM099122 GC0XM099858 GC0XM100893 GC0XM100973 GC0XM090894


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NXF5 Gene:
This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is
implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in
other family members that are required for export activity, and may be an evolving pseudogene. Alternatively
spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and
may not express proteins in vivo. (provided by RefSeq, Jul 2009)

GeneCards Summary for NXF5 Gene: 
NXF5 (nuclear RNA export factor 5) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NXF5 include pelizaeus-merzbacher disease, and intellectual disability, and among its related super-pathways are Influenza A. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is NXF1.

UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4
Function: Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in
polarized cytoplasmic transport and localization of mRNA in neurons




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NXF5
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for NXF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22

NXF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXF5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM101087:  view genomic region     (about GC identifiers)

Start:
101,087,085 bp from pter      End:
101,112,549 bp from pter
Size:
25,465 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4 (See protein sequence)
Recommended Name: Nuclear RNA export factor 5  
Size: 397 amino acids; 45628 Da
Subunit: Interacts with NXT1 and NXT2
Subcellular location: Cytoplasm. Nucleus. Note=Mainly localized in the cytoplasm of cells and more particularly in
the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected
at nuclear rim
Secondary accessions: A2RRM0 B1AV82 B1AV83 B1AV84 B1AV85 Q9H1B0 Q9H1B1 Q9H1B2 Q9H1B3
Alternative splicing: 6 isoforms:  Q9H1B4-1   Q9H1B4-2   Q9H1B4-3   Q9H1B4-4   Q9H1B4-5   Q9H1B4-6   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for NXF5: NX_Q9H1B4

Explore proteomics data for NXF5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H1B4

  • NXF5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NXF5 Protein Expression
    REFSEQ proteins: NP_116564.2  
    ENSEMBL proteins: 
     ENSP00000263032   ENSP00000361889   ENSP00000422976   ENSP00000354539   ENSP00000331535  
     ENSP00000426978   ENSP00000442401   ENSP00000355286  

    Human Recombinant Protein Products for NXF5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NXF5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NXF5
    GenScript Custom Purified and Recombinant Proteins Services for NXF5
    Novus Biologicals NXF5 Protein
    Novus Biologicals NXF5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NXF5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015629actin cytoskeleton IDA--

    NXF5 for ontologies           About GeneDecksing



    NXF5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NXF5
    GenScript Custom Superior Antibodies Services for NXF5
    Novus Biologicals NXF5 Antibodies
    Abcam antibodies for NXF5
    Cloud-Clone Corp. Antibodies for NXF5 
    Search ThermoFisher Antibodies for NXF5
    LSBio Antibodies in human, mouse, rat for NXF5 

    Assay Products for NXF5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NXF5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NXF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NXF5 
    Cloud-Clone Corp. CLIAs for NXF5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015245 Tap_RNA-bd
     IPR001611 Leu-rich_rpt
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9H1B4

    ProtoNet protein and cluster: Q9H1B4

    1 Blocks protein domain: IPB002075 Nuclear transport factor 2 (NTF2)

    UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4
    Domain: The NTF2 domain heterodimerizes with NXT1 and NXT2 (By similarity)
    Domain: The RNA-binding domain is a non-canonical RNP-type domain
    Similarity: Belongs to the NXF family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 NTF2 domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    NXF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXF5_HUMAN, Q9H1B4
    Function: Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in
    polarized cytoplasmic transport and localization of mRNA in neurons

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IDA11566096
    GO:0005515protein binding IPI11566096
         
    NXF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NXF5:
     Cell cycle / mitosis defect 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NXF5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NXF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXF5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NXF5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXF5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NXF5
    SwitchGear 3'UTR luciferase reporter plasmidNXF5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NXF5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXF5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NXF5
    Sirion Biotech Customized adenovirus for overexpression of NXF5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NXF5 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NXF5 (NM_032946)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF5
    Sirion Biotech Customized lentivirus for stable overexpression of NXF5 
                         Customized lentivirus expression plasmids for stable overexpression of NXF5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NXF5
    Search LifeMap BioReagents cell lines for NXF5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NXF5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    2mRNA surveillance pathway
    mRNA surveillance pathway
    3Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes
    4RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5         Kegg Pathways  (Kegg details for NXF5):
        Ribosome biogenesis in eukaryotes
    RNA transport
    mRNA surveillance pathway
    Influenza A
    Herpes simplex infection


    NXF5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for NXF5 (ENSP000002630324) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALYREFENSP000003318174STRING: ENSP00000331817
    EIF4A3ENSP000002693494STRING: ENSP00000269349
    NUP98ENSP000003160324STRING: ENSP00000316032
    NUPL2ENSP000002587424STRING: ENSP00000258742
    NXT1ENSP000002549984STRING: ENSP00000254998
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006406mRNA export from nucleus IDA11566096
    GO:0007275multicellular organismal development IEP11566096
    GO:0050658RNA transport IDA11566096

    NXF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXF5

    Search CenterWatch for drugs/clinical trials and news about NXF5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NXF5 gene (5 alternative transcripts): 
    NM_032946.2  NM_033152.1  NM_033153.1  NM_033154.1  NM_033155.1  

    Unigene Cluster for NXF5:

    Nuclear RNA export factor 5
    Hs.307077
    Unigene Representative Sequence: AJ277654
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263032(uc004eih.1) ENST00000372803(uc004eij.1) ENST00000493509(uc004eii.1)
    ENST00000361330(uc004eik.1) ENST00000332614(uc004eil.1) ENST00000473265
    ENST00000537026(uc011mrk.1) ENST00000361708
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NXF5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NXF5
    SwitchGear 3'UTR luciferase reporter plasmidNXF5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NXF5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXF5
    Clone
    Products:
         
    OriGene clones in human, mouse for NXF5 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NXF5 (NM_032946)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NXF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF5
    Sirion Biotech Customized lentivirus for stable overexpression of NXF5 
                         Customized lentivirus expression plasmids for stable overexpression of NXF5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NXF5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NXF5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF5

    Additional mRNA sequence: 

    AJ277654.1 AJ277655.1 AJ277656.1 AJ277657.1 AJ277658.1 BC131708.1 NR_028089.1 

    1 DOTS entry:

    DT.91758145 

    10 AceView cDNA sequences:

    AJ277656 NM_033154 AJ277657 NM_033153 AJ277658 NM_033155 NM_033152 AJ277654 
    AJ277655 NM_032946 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXF5 expression in normal human tissues (normalized intensities)      NXF5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NXF5 Expression
    About this image


    NXF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See NXF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXF5

    SOURCE GeneReport for Unigene cluster: Hs.307077
        SABiosciences Custom PCR Arrays for NXF5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NXF5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NXF5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NXF5 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    32(a)
    possible ortholog
    GL343739.1(136184-168794)
    zebrafish
    (Danio rerio)
    Actinopterygii CU468164.16
    nxf16
    (see all 4)
    nuclear RNA export factor 1
    (see all 4)
    45(a)
    27(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    14(9002608-9013043)
    21(26058501-26071321)
    fruit fly
    (Drosophila melanogaster)
    Insecta sbr6
    Nxf36
    (see all 3)
    Nuclear export factor 3
    (see all 3)
    15(a)
    13(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    X(10726785-10741125)
    3L(13958303-13965106)
    worm
    (Caenorhabditis elegans)
    Secernentea nxf-26
    nxf-16
    Nuclear RNA export factor 1
    16(a)
    14(a)
    many ↔ many
    many ↔ many
    V(14416115-14417829)
    V(14412405-14415792)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MEX676
    Poly(A)RNA binding protein involved in nuclear mRN...
    11(a)
    1 → many
    XVI(229039-230838)
            Species with no ortholog for NXF5

    ENSEMBL Gene Tree for NXF5 (if available)
    TreeFam Gene Tree for NXF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXF5 gene
    NXF12  NXF32  NXF2B2  NXF22  
    4 SIMAP similar genes for NXF5 using alignment to 2 protein entries:     NXF5_HUMAN (see all proteins):
    NXF2B    NXF2    NXF1    NXF3

    NXF5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NXF5
    PGOHUM00000241917


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/500 SNPs in NXF5 are shown (see all 500)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904867601,2
    --101054239(+) AATGTC/GAGATT 2 -- ds50010--------
    rs1817991521,2
    --101054290(+) TGAACC/TCCTTC 2 -- ds50010--------
    rs1474580011,2
    C--101054373(+) CCCACC/TGCAGG 2 -- ds50010--------
    rs59450791,2
    C,F,A,H--101054445(+) TGGAAG/CCCCCT 2 -- ds50015Minor allele frequency- C:0.02NS EA NA 410
    rs1405803361,2
    --101054493(+) AGGTCA/GAGCAT 2 -- ds50010--------
    rs1896031401,2
    --101054545(+) GGGCGC/TGTGTC 2 -- ds50010--------
    rs1445316941,2
    --101054599(+) GCCAGA/TTCATT 2 -- ds50010--------
    rs66163051,2
    C,F,A,H--101054674(+) CTCATG/CGTTGG 2 -- ds50018Minor allele frequency- C:0.10NS EA NA WA 426
    rs1813221251,2
    --101054681(+) TTGGGG/TCAGGG 2 -- ds50010--------
    rs1854552681,2
    --101054705(+) GGGCAC/TACAAC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for NXF5 (101087085 - 101112549 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NXF5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv987918CNV Deletion20482838
    esv2740360CNV Deletion23290073
    esv2740359CNV Deletion23290073
    nsv7015CNV Loss18451855


    Human Gene Mutation Database (HGMD): NXF5

    Locus Specific Mutation Databases (LSDB): NXF5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NXF5
    DNA2.0 Custom Variant and Variant Library Synthesis for NXF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300319    OMIM disorders: --

    UniProtKB/Swiss-Prot: NXF5_HUMAN, Q9H1B4
  • Note=A chromosomal aberration involving NXF5 has been observed in one patient with a syndromic form of
    mental retardation and short stature. Pericentric inversion inv(X)(p21.1;q22) that interrupts NXF5

  • 7 diseases for NXF5:    About MalaCards
    pelizaeus-merzbacher disease    intellectual disability    premature ovarian failure    short stature
    influenza    mental retardation    neuronitis


    NXF5 for disorders           About GeneDecksing


    Export disorders for NXF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXF5 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with NXF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. (PubMed id 11566096)1, 2, 3, 9 Jun L.... Froyen G. (2001)
    2. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    3. Inv(X)(p21.1;q22.1) in a man with mental retardation, short stature, general muscle wasting, and facial dysmorphism: clinical study and mutation analysis of the NXF5 gene. (PubMed id 12784308)1, 9 Frints S.G....Froyen G. (2003)
    4. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PubMed id 19377476)1 Tarpey P.S.... Stratton M.R. (2009)
    5. Formation of a Tap/NXF1 Homotypic Complex Is Mediated through the Amino-Terminal Domain of Tap and Enhances Interaction with Nucleoporins. (PubMed id 17978099)1 Matzat L.H....Levesque L. (2008)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PubMed id 11073998)1 Herold A.... Izaurralde E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55998 HGNC: 8075 AceView: NXF5 Ensembl:ENSG00000126952 euGenes: HUgn55998
    ECgene: NXF5 Kegg: 55998 H-InvDB: NXF5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NXF5 gene:
    Search GeneIP for patents involving NXF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NXF5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NXF5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NXF5  
     OriGene qSTAR qPCR primer pairs in human, mouse for NXF5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NXF5   OriGene Custom Protein Services for NXF5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NXF5
     QIAGEN SeqTarget long-range PCR primers for resequencing NXF5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXF5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF5
     GenScript Custom Purified and Recombinant Proteins Services for NXF5 GenScript cDNA clones with any tag delivered in your preferred vector for NXF5
     GenScript Custom Assay Services for NXF5 GenScript Custom Superior Antibodies Services for NXF5
     GenScript Custom overexpressing Cell Line Services for NXF5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for NXF5
     Search Chromatin IP Primers for NXF5
     RT2 qPCR Primer Assay in human, mouse / rat NXF5
     Search GNC Networks for NXF5
     SABiosciences Custom PCR Arrays for NXF5
     Search Tocris compounds for NXF5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NXF5 antibodies
     NXF5 proteins
     NXF5 lysates
     Antibodies for NXF5
     See all of Abcam's Antibodies, Kits and Proteins for NXF5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NXF5
     Antibodies for NXF5
     ELISAs for NXF5
     CLIAs for NXF5
     Search LifeMap BioReagents cell lines for NXF5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF5
     SwitchGear 3'UTR luciferase reporter plasmids for NXF5
     SwitchGear Promoter luciferase reporter plasmids for NXF5
     Search ThermoFisher Antibodies for NXF5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NXF5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NXF5
    Customized:
     lentivirus for stable overexpression of NXF5
     lentivirus expression plasmids for stable overexpression of NXF5
     adenovirus for overexpression of NXF5
     LSBio Antibodies in human, mouse, rat for NXF5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NXF5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4