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Aliases for NXF3 Gene

Aliases for NXF3 Gene

  • Nuclear RNA Export Factor 3 2 3 5
  • TAP-Like Protein 3 3 4
  • TAPL-3 3 4
  • TAPL3 4

External Ids for NXF3 Gene

Previous GeneCards Identifiers for NXF3 Gene

  • GC0XM097632
  • GC0XM099239
  • GC0XM100363
  • GC0XM101102
  • GC0XM102136
  • GC0XM102219
  • GC0XM102330
  • GC0XM091994

Summaries for NXF3 Gene

Entrez Gene Summary for NXF3 Gene

  • This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]

GeneCards Summary for NXF3 Gene

NXF3 (Nuclear RNA Export Factor 3) is a Protein Coding gene. Diseases associated with NXF3 include Pelizaeus-Merzbacher Disease. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include RNA binding and mRNA binding. An important paralog of this gene is NXF2.

UniProtKB/Swiss-Prot for NXF3 Gene

  • May function as a tissue-specific nuclear mRNA export factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXF3 Gene

Genomics for NXF3 Gene

Regulatory Elements for NXF3 Gene


Promoters for NXF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NXF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXF3 Gene

Chromosome:
X
Start:
103,075,810 bp from pter
End:
103,093,125 bp from pter
Size:
17,316 bases
Orientation:
Minus strand

Genomic View for NXF3 Gene

Genes around NXF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXF3 Gene

Proteins for NXF3 Gene

  • Protein details for NXF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4D5-NXF3_HUMAN
    Recommended name:
    Nuclear RNA export factor 3
    Protein Accession:
    Q9H4D5
    Secondary Accessions:
    • B4DYS7
    • Q5H9I1
    • Q9H1A9

    Protein attributes for NXF3 Gene

    Size:
    531 amino acids
    Molecular mass:
    60102 Da
    Quaternary structure:
    • Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor.
    SequenceCaution:
    • Sequence=CAC20434.1; Type=Frameshift; Positions=463; Evidence={ECO:0000305};

    Alternative splice isoforms for NXF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXF3 Gene

Proteomics data for NXF3 Gene at MOPED

Post-translational modifications for NXF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NXF3
  • Santa Cruz Biotechnology (SCBT) Antibodies for NXF3

No data available for DME Specific Peptides for NXF3 Gene

Domains & Families for NXF3 Gene

Suggested Antigen Peptide Sequences for NXF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4D5

UniProtKB/Swiss-Prot:

NXF3_HUMAN :
  • Lacks C-terminal domain that mediates direct interactions with nucleoporins.
  • Belongs to the NXF family.
Domain:
  • Lacks C-terminal domain that mediates direct interactions with nucleoporins.
  • Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain.
  • The RNA-binding domain is a non-canonical RNP-type domain.
  • Contains 1 NTF2 domain.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the NXF family.
genes like me logo Genes that share domains with NXF3: view

No data available for Gene Families for NXF3 Gene

Function for NXF3 Gene

Molecular function for NXF3 Gene

UniProtKB/Swiss-Prot Function:
May function as a tissue-specific nuclear mRNA export factor.

Gene Ontology (GO) - Molecular Function for NXF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IEA --
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with NXF3: view
genes like me logo Genes that share phenotypes with NXF3: view

Animal Models for NXF3 Gene

MGI Knock Outs for NXF3:

Animal Model Products

miRNA for NXF3 Gene

miRTarBase miRNAs that target NXF3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NXF3 Gene

Localization for NXF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXF3 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXF3 Gene COMPARTMENTS Subcellular localization image for NXF3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NXF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 11545741
genes like me logo Genes that share ontologies with NXF3: view

Pathways & Interactions for NXF3 Gene

genes like me logo Genes that share pathways with NXF3: view

Gene Ontology (GO) - Biological Process for NXF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with NXF3: view

No data available for SIGNOR curated interactions for NXF3 Gene

Drugs & Compounds for NXF3 Gene

No Compound Related Data Available

Transcripts for NXF3 Gene

Unigene Clusters for NXF3 Gene

Nuclear RNA export factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2:
SP3: -

Relevant External Links for NXF3 Gene

GeneLoc Exon Structure for
NXF3
ECgene alternative splicing isoforms for
NXF3

Expression for NXF3 Gene

mRNA expression in normal human tissues for NXF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXF3 Gene

This gene is overexpressed in Testis (x37.0).

Protein differential expression in normal tissues from HIPED for NXF3 Gene

This gene is overexpressed in Testis (61.5) and Ovary (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NXF3 Gene



SOURCE GeneReport for Unigene cluster for NXF3 Gene Hs.60386

mRNA Expression by UniProt/SwissProt for NXF3 Gene

Q9H4D5-NXF3_HUMAN
Tissue specificity: Expressed at high level in testis and at low level in a small number of tissues.
genes like me logo Genes that share expression patterns with NXF3: view

Protein tissue co-expression partners for NXF3 Gene

- Elite partner

Primer Products

Orthologs for NXF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100337148 35
  • 74.4 (n)
  • 62.05 (a)
-- 36
  • 56 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NXF3 35
  • 79.17 (n)
  • 65.15 (a)
NXF3 36
  • 56 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nxf3 35
  • 69.44 (n)
  • 53.96 (a)
Nxf3 16
Nxf3 36
  • 47 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NXF3 35
  • 99 (n)
  • 98.49 (a)
NXF3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxf3 35
  • 69.89 (n)
  • 53.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta nxf2 36
  • 12 (a)
ManyToMany
Nxf3 36
  • 14 (a)
ManyToMany
sbr 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nxf-1 36
  • 17 (a)
ManyToMany
nxf-2 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for NXF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NXF3 Gene

ENSEMBL:
Gene Tree for NXF3 (if available)
TreeFam:
Gene Tree for NXF3 (if available)

Paralogs for NXF3 Gene

Paralogs for NXF3 Gene

(5) SIMAP similar genes for NXF3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NXF3 Gene

genes like me logo Genes that share paralogs with NXF3: view

Variants for NXF3 Gene

Sequence variations from dbSNP and Humsavar for NXF3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs2301387 - 103,083,257(-) TGTCA(A/T)CCCTG reference, missense
rs747670072 -- 103,077,731(+) TTGTC(A/G)TTCAC reference, synonymous-codon
rs747678542 -- 103,094,828(+) AAAAT(G/T)TGGTT upstream-variant-2KB
rs747735783 -- 103,093,519(+) TCCTG(A/C)AGGTG upstream-variant-2KB
rs747782077 -- 103,083,298(+) GGCTG(A/C)GTAAA intron-variant

Variation tolerance for NXF3 Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXF3 Gene

Human Gene Mutation Database (HGMD)
NXF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NXF3 Gene

Disorders for NXF3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NXF3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pelizaeus-merzbacher disease
  • leukodystrophy, sudanophilic
- elite association - COSMIC cancer census association via MalaCards
Search NXF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NXF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXF3
genes like me logo Genes that share disorders with NXF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXF3 Gene

Publications for NXF3 Gene

  1. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PMID: 11073998) Herold A. … Izaurralde E. (Mol. Cell. Biol. 2000) 2 3 4 23 67
  2. Two closely related human nuclear export factors utilize entirely distinct export pathways. (PMID: 11545741) Yang J. … Cullen B.R. (Mol. Cell 2001) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M. … Hayward S.D. (J. Virol. 2012) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for NXF3 Gene

Sources for NXF3 Gene

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