External Ids for NXF3 Gene
Previous GeneCards Identifiers for NXF3 Gene
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
GeneCards Summary for NXF3 Gene
NXF3 (Nuclear RNA Export Factor 3) is a Protein Coding gene. Diseases associated with NXF3 include Pelizaeus-Merzbacher Disease. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include RNA binding and mRNA binding. An important paralog of this gene is NXF2.
UniProtKB/Swiss-Prot for NXF3 Gene
May function as a tissue-specific nuclear mRNA export factor.