External Ids for NXF3 Gene
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]
GeneCards Summary for NXF3 Gene
NXF3 (Nuclear RNA Export Factor 3) is a Protein Coding gene. Diseases associated with NXF3 include pelizaeus-merzbacher disease. Among its related pathways are Influenza A and RNA transport. GO annotations related to this gene include nucleotide binding and mRNA binding. An important paralog of this gene is NXF5.
UniProtKB/Swiss-Prot for NXF3 Gene
May function as a tissue-specific nuclear mRNA export factor