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Aliases for NXF3 Gene

Aliases for NXF3 Gene

  • Nuclear RNA Export Factor 3 2 3
  • TAP-Like Protein 3 3 4
  • TAPL-3 3 4
  • TAPL3 4

External Ids for NXF3 Gene

Previous GeneCards Identifiers for NXF3 Gene

  • GC0XM097632
  • GC0XM099239
  • GC0XM100363
  • GC0XM101102
  • GC0XM102136
  • GC0XM102219
  • GC0XM102330
  • GC0XM091994

Summaries for NXF3 Gene

Entrez Gene Summary for NXF3 Gene

  • This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008]

GeneCards Summary for NXF3 Gene

NXF3 (Nuclear RNA Export Factor 3) is a Protein Coding gene. Diseases associated with NXF3 include pelizaeus-merzbacher disease. Among its related pathways are Influenza A and RNA transport. GO annotations related to this gene include nucleotide binding and mRNA binding. An important paralog of this gene is NXF5.

UniProtKB/Swiss-Prot for NXF3 Gene

  • May function as a tissue-specific nuclear mRNA export factor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXF3 Gene

Genomics for NXF3 Gene

Regulatory Elements for NXF3 Gene

Genomic Location for NXF3 Gene

103,075,810 bp from pter
103,093,125 bp from pter
17,316 bases
Minus strand

Genomic View for NXF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXF3 Gene

Proteins for NXF3 Gene

  • Protein details for NXF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear RNA export factor 3
    Protein Accession:
    Secondary Accessions:
    • B4DYS7
    • Q5H9I1
    • Q9H1A9

    Protein attributes for NXF3 Gene

    531 amino acids
    Molecular mass:
    60102 Da
    Quaternary structure:
    • Interacts with NXT1, NXT2, E1B-AP5 and CRM1 nuclear export factor
    • Sequence=CAC20434.1; Type=Frameshift; Positions=463; Evidence={ECO:0000305};

    Alternative splice isoforms for NXF3 Gene


neXtProt entry for NXF3 Gene

Proteomics data for NXF3 Gene at MOPED

Post-translational modifications for NXF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXF3 Gene

Domains for NXF3 Gene

Suggested Antigen Peptide Sequences for NXF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H4D5
  • Lacks C-terminal domain that mediates direct interactions with nucleoporins
  • Contains a novel CRM1-dependent nuclear export signal that compensates in cis for the loss of the nuclear pore targeting domain
  • The RNA-binding domain is a non-canonical RNP-type domain
  • Contains 1 NTF2 domain.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the NXF family.
genes like me logo Genes that share domains with NXF3: view

No data available for Gene Families for NXF3 Gene

Function for NXF3 Gene

Molecular function for NXF3 Gene

UniProtKB/Swiss-Prot Function:
May function as a tissue-specific nuclear mRNA export factor

Gene Ontology (GO) - Molecular Function for NXF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding --
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 11545741
genes like me logo Genes that share ontologies with NXF3: view

Phenotypes for NXF3 Gene

genes like me logo Genes that share phenotypes with NXF3: view

Animal Models for NXF3 Gene

MGI Knock Outs for NXF3:

Animal Model Products

miRNA for NXF3 Gene

miRTarBase miRNAs that target NXF3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NXF3 Gene

Localization for NXF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXF3 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

Jensen Localization Image for NXF3 Gene COMPARTMENTS Subcellular localization image for NXF3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for NXF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 11545741
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 11545741
GO:0042272 nuclear RNA export factor complex IDA 11545741
genes like me logo Genes that share ontologies with NXF3: view

Pathways for NXF3 Gene

genes like me logo Genes that share pathways with NXF3: view

Gene Ontology (GO) - Biological Process for NXF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus IDA 11545741
GO:0006810 transport --
GO:0016973 poly(A)+ mRNA export from nucleus IEA --
genes like me logo Genes that share ontologies with NXF3: view

Transcripts for NXF3 Gene

Unigene Clusters for NXF3 Gene

Nuclear RNA export factor 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP3: -

Relevant External Links for NXF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NXF3 Gene

mRNA expression in normal human tissues for NXF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NXF3 Gene

This gene is overexpressed in Testis (37.0).

Protein differential expression in normal tissues for NXF3 Gene

This gene is overexpressed in Testis (61.5) and Ovary (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NXF3 Gene

SOURCE GeneReport for Unigene cluster for NXF3 Gene Hs.60386

mRNA Expression by UniProt/SwissProt for NXF3 Gene

Tissue specificity: Expressed at high level in testis and at low level in a small number of tissues
genes like me logo Genes that share expressions with NXF3: view

Expression partners for NXF3 Gene

In Situ Assay Products

Orthologs for NXF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100337148 35
  • 74.4 (n)
  • 62.05 (a)
-- 36
  • 56 (a)
-- 36
  • 55 (a)
-- 36
  • 53 (a)
-- 36
  • 52 (a)
-- 36
  • 49 (a)
-- 36
  • 55 (a)
(Canis familiaris)
Mammalia NXF3 35
  • 79.17 (n)
  • 65.15 (a)
NXF3 36
  • 56 (a)
(Mus musculus)
Mammalia Nxf3 35
  • 69.44 (n)
  • 53.96 (a)
Nxf3 16
Nxf3 36
  • 47 (a)
(Pan troglodytes)
Mammalia NXF3 35
  • 99 (n)
  • 98.49 (a)
NXF3 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Nxf3 35
  • 69.89 (n)
  • 53.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta nxf2 36
  • 12 (a)
Nxf3 36
  • 14 (a)
sbr 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea nxf-1 36
  • 17 (a)
nxf-2 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for NXF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NXF3 Gene

Gene Tree for NXF3 (if available)
Gene Tree for NXF3 (if available)

Paralogs for NXF3 Gene

Paralogs for NXF3 Gene

Selected SIMAP similar genes for NXF3 Gene using alignment to 5 proteins: Pseudogenes for NXF3 Gene

genes like me logo Genes that share paralogs with NXF3: view

Variants for NXF3 Gene

Sequence variations from dbSNP and Humsavar for NXF3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs916218 -- 103,082,388(-) GTCTA(C/T)GTGGT intron-variant
rs1029305 -- 103,084,678(-) GTACC(A/G)GCCAG intron-variant
rs1894463 -- 103,081,468(-) AAGGC(A/G)TCAGC intron-variant
rs2027835 -- 103,094,071(-) GCCTC(A/G)GCCAG upstream-variant-2KB
rs2027836 -- 103,093,946(-) cagca(A/C)gctgt upstream-variant-2KB

Relevant External Links for NXF3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NXF3 Gene

Disorders for NXF3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NXF3 Gene in MalaCards »

(1) Diseases for NXF3 Gene including...

(1) University of Copenhagen DISEASES for NXF3 Gene

genes like me logo Genes that share disorders with NXF3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for NXF3 Gene

Publications for NXF3 Gene

  1. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PMID: 11073998) Herold A. … Izaurralde E. (Mol. Cell. Biol. 2000) 2 3 4 23
  2. Two closely related human nuclear export factors utilize entirely distinct export pathways. (PMID: 11545741) Yang J. … Cullen B.R. (Mol. Cell 2001) 3 4 23
  3. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. (PMID: 11566096) Jun L. … Froyen G. (Curr. Biol. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NXF3 Gene

Sources for NXF3 Gene

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