NXF2B Gene
protein-coding GIFtS: 43
GCID: GC0XM101615
|
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nuclear RNA export factor 2B
| |
Aliases for NXF2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Nuclear RNA Export Factor 2B1 2 | | Nuclear RNA Export Factor 22 | | BA353J17.11 | | CT393 | | Cancer/Testis Antigen 392 3 | | TAPL-23 | | TAP-Like Protein 22 3 | | TAPL23 |
Export aliases for NXF2B gene to outside databasesPrevious GC identifer: GC0XM101503 |
Summaries for NXF2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0Function: Involved in the export of mRNA from the nucleus to the cytoplasm
|
Genomic Views for NXF2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_018934.1 NC_000023.10 NT_011651.17
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NXF2B gene promoter: STAT1 AML1a GCNF STAT1beta GATA-1 STAT1alpha CP2 HSF2 GCNF-1 GCNF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for NXF2B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF2B |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22NXF2B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM101615: view genomic region
(about GC identifiers)
Start:
|
101,615,316 bp from pter |
End:
|
101,726,732 bp from pter |
Size:
|
111,417 bases |
Orientation:
|
minus strand |
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Proteins for NXF2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0 (See
protein sequence)Recommended Name: Nuclear RNA export factor 2 Size: 626 amino acids; 71627 Da
Subunit: Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope.Shuttles between the nucleus and the cytoplasm
Sequence caution: Sequence=AAK31975.1; Type=Erroneous initiation; Sequence=BAA91154.1; Type=Erroneous initiation;Sequence=CAB75659.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to either intronretention or a splicing event;
Secondary accessions: Q9BXU4 Q9NSS1 Q9NX66Explore the universe of human proteins at neXtProt for NXF2B: NX_Q9GZY0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9GZY0 NXF2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001093156.1 ENSEMBL proteins: ENSP00000361838 ENSP00000361835 ENSP00000361836 ENSP00000396447 ENSP00000413087 Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
NXF2B for ontologies About GeneDecksing
NXF2B Antibody Products: Assay Products for NXF2B: |
Protein
Domains / Families for NXF2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NXF2B for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9GZY0ProtoNet protein and cluster: Q9GZY0 2 Blocks protein families: IPB002075 Nuclear transport factor 2 (NTF2) IPB005637 TAP C-terminal domain
UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0Domain: The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required forNXF2-mediated nuclear mRNA exportDomain: The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleusDomain: The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-likedomain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary andsufficient for localization of NXF2 to the nuclear rimDomain: The RNA-binding domain is a non-canonical RNP-type domainSimilarity: Belongs to the NXF familySimilarity: Contains 4 LRR (leucine-rich) repeatsSimilarity: Contains 1 NTF2 domainSimilarity: Contains 1 RRM (RNA recognition motif) domainSimilarity: Contains 1 TAP-C domain |
Function for NXF2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0Function: Involved in the export of mRNA from the nucleus to the cytoplasm
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXF2B OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXF2B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NXF2B (NM_001099686) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXF2B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NXF2B  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF2B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NXF2B for ontologies About GeneDecksing
|
Pathways & Interactions for NXF2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA surveillance pathway | | | 2 | Ribosome biogenesis in eukaryotes | | | 3 | RNA transport | | | 4 | Measles | |
Pathway sources See GeneCards unified pathways Show all pathways
4
Kegg Pathways (Kegg details for NXF2B):
NXF2B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NXF2B
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
 5 Interacting proteins for NXF2B (Q9GZY03 ENSP000003618354) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
NXF2B for ontologies About GeneDecksing
|
Drugs & Compounds for NXF2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for NXF2B Search CenterWatch for drugs/clinical trials and news about NXF2B / NXF2 
|
Transcripts for NXF2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for NXF2B gene: NM_001099686.2 Unigene Cluster for NXF2B: Nuclear RNA export factor 2B Hs.648337 [show with all ESTs]Unigene Representative Sequence: BX6472326 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372752(uc004eiz.4) ENST00000372749(uc004eiy.4) ENST00000372750 ENST00000489531 ENST00000457521(uc022cav.1 uc004ejb.4) ENST00000412230(uc010nob.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXF2B OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXF2B OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NXF2B (NM_001099686) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXF2B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NXF2B  |
Additional cDNA sequence: AF285596.1 AK000423.1 AK308255.1 BX647232.1 4 DOTS entries: DT.103434 DT.121307672 DT.95341451 DT.95367446 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NXF2B About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for NXF2B
|
Expression for NXF2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NXF2B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See NXF2B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NXF2B
SOURCE GeneReport for Unigene cluster: Hs.648337 UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0Tissue specificity: Expressed almost exclusively in testis. Also expressed in several cancers SABiosciences Custom PCR Arrays for NXF2B
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXF2B Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NXF2B | |  | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF2B | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF2B | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF2B |
Orthologs for NXF2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NXF2B gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for NXF2B (if available) TreeFam Gene Tree for NXF2B (if available)  |
Paralogs for NXF2B gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for NXF2B gene
- NXF21 2 NXF12 NXF32 NXF52
5 SIMAP similar genes for NXF2B using alignment to 3 protein entries: NXF2_HUMAN (see all proteins):NXF2 NXF5 NXF1 DKFZp667O0311 NXF3
NXF2B for paralogs About GeneDecksing
|
Genomic Variants for NXF2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr X pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for NXF2B (101615316 - 101726732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NXF2B: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXF2B |
|
Disorders
/ Diseases for NXF2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NXF2B for disorders About GeneDecksing
3 diseases for NXF2B: About MalaCardspelizaeus-merzbacher disease spermatocytoma influenza 2 diseases from the University of Copenhagen DISEASES database for NXF2B:Male infertility Spermatocytoma Export disorders for NXF2B gene to outside databases
|
Publications for NXF2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NXF2B gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with NXF2B) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PubMed id 16382448)1, 3 Chen Y.T....Jongeneel C.V. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PubMed id 12704671)1, 2 Loriot A.... De Smet C. (2003)
- NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. (PubMed id 11566096)1, 2 Jun L.... Froyen G. (2001)
- An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2 Wang P.J.... Page D.C. (2001)
- TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PubMed id 11073998)1, 2 Herold A.... Izaurralde E. (2000)
- Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. (PubMed id 10567585)1, 2 Black B.E.... Paschal B.M. (1999)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for NXF2B gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NXF2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NXF2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NXF2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for NXF2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NXF2B gene: Search GeneIP for patents involving NXF2B
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for NXF2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| |
 |  |  |  | |
| | | Search Tocris compounds for NXF2B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF2B |
|  |  |  | | | Search ThermoFisher Antibodies for NXF2B |
| | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NXF2B |
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