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Aliases for NXF2B Gene

Aliases for NXF2B Gene

  • Nuclear RNA Export Factor 2B 2 3
  • Cancer/Testis Antigen 39 3 4
  • TAP-Like Protein 2 3 4
  • BA353J17.1 3
  • NXF2 NXF2B 4
  • TCP11X1 3
  • TAPL-2 4
  • TAPL2 4
  • CT39 4

External Ids for NXF2B Gene

Previous GeneCards Identifiers for NXF2B Gene

  • GC0XM101503
  • GC0XM101615

Summaries for NXF2B Gene

Entrez Gene Summary for NXF2B Gene

  • This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Jun 2015]

GeneCards Summary for NXF2B Gene

NXF2B (Nuclear RNA Export Factor 2B) is a Protein Coding gene. Among its related pathways are Influenza A and RNA transport. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is NXF2.

UniProtKB/Swiss-Prot for NXF2B Gene

  • Involved in the export of mRNA from the nucleus to the cytoplasm

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXF2B Gene

Genomics for NXF2B Gene

Regulatory Elements for NXF2B Gene

Genomic Location for NXF2B Gene

Chromosome:
X
Start:
102,360,395 bp from pter
End:
102,463,274 bp from pter
Size:
102,880 bases
Orientation:
Minus strand

Genomic View for NXF2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXF2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXF2B Gene

Proteins for NXF2B Gene

  • Protein details for NXF2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZY0-NXF2_HUMAN
    Recommended name:
    Nuclear RNA export factor 2
    Protein Accession:
    Q9GZY0
    Secondary Accessions:
    • Q9BXU4
    • Q9NSS1
    • Q9NX66

    Protein attributes for NXF2B Gene

    Size:
    626 amino acids
    Molecular mass:
    71627 Da
    Quaternary structure:
    • Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.
    • Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.
    SequenceCaution:
    • Sequence=AAK31975.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91154.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB75659.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to either intron retention or a splicing event.; Evidence={ECO:0000305};

neXtProt entry for NXF2B Gene

Proteomics data for NXF2B Gene at MOPED

Post-translational modifications for NXF2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXF2B Gene

No data available for DME Specific Peptides for NXF2B Gene

Domains & Families for NXF2B Gene

Suggested Antigen Peptide Sequences for NXF2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZY0

UniProtKB/Swiss-Prot:

NXF2_HUMAN :
  • The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export
  • Belongs to the NXF family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export
  • The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus
  • The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim
  • The RNA-binding domain is a non-canonical RNP-type domain
  • Contains 1 NTF2 domain.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 TAP-C domain.
Family:
  • Belongs to the NXF family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NXF2B: view

No data available for Gene Families for NXF2B Gene

Function for NXF2B Gene

Molecular function for NXF2B Gene

UniProtKB/Swiss-Prot Function:
Involved in the export of mRNA from the nucleus to the cytoplasm

Gene Ontology (GO) - Molecular Function for NXF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding NAS 11073998
GO:0005515 protein binding IPI 25662211
GO:0044822 poly(A) RNA binding IBA --
genes like me logo Genes that share ontologies with NXF2B: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NXF2B Gene

Localization for NXF2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXF2B Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXF2B Gene COMPARTMENTS Subcellular localization image for NXF2B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NXF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0042272 nuclear RNA export factor complex NAS 11073998
genes like me logo Genes that share ontologies with NXF2B: view

Pathways & Interactions for NXF2B Gene

genes like me logo Genes that share pathways with NXF2B: view

Pathways by source for NXF2B Gene

Interacting Proteins for NXF2B Gene

Selected Interacting proteins: Q9GZY0-NXF2_HUMAN for NXF2B Gene via I2D

Gene Ontology (GO) - Biological Process for NXF2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus NAS 11073998
GO:0006810 transport --
GO:0007275 multicellular organismal development ISS --
GO:0016973 poly(A)+ mRNA export from nucleus IBA --
GO:0050658 RNA transport ISS --
genes like me logo Genes that share ontologies with NXF2B: view

No data available for SIGNOR curated interactions for NXF2B Gene

Drugs & Compounds for NXF2B Gene

No Compound Related Data Available

Transcripts for NXF2B Gene

mRNA/cDNA for NXF2B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NXF2B Gene

Nuclear RNA export factor 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXF2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXF2B Gene

No ASD Table

Relevant External Links for NXF2B Gene

GeneLoc Exon Structure for
NXF2B
ECgene alternative splicing isoforms for
NXF2B

Expression for NXF2B Gene

mRNA expression in normal human tissues for NXF2B Gene

mRNA differential expression in normal tissues according to GTEx for NXF2B Gene

This gene is overexpressed in Testis (x27.3) and Pituitary (x11.6).

Protein differential expression in normal tissues from HIPED for NXF2B Gene

This gene is overexpressed in Testis (29.6), Urinary Bladder (27.1), and Ovary (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXF2B Gene



SOURCE GeneReport for Unigene cluster for NXF2B Gene Hs.648337

mRNA Expression by UniProt/SwissProt for NXF2B Gene

Q9GZY0-NXF2_HUMAN
Tissue specificity: Expressed almost exclusively in testis. Also expressed in several cancers.
genes like me logo Genes that share expression patterns with NXF2B: view

Protein tissue co-expression partners for NXF2B Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NXF2B Gene

Orthologs for NXF2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for NXF2B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NXF2 35
  • 82.37 (n)
  • 73.72 (a)
mouse
(Mus musculus)
Mammalia Nxf2 35
  • 70.93 (n)
  • 57.85 (a)
chimpanzee
(Pan troglodytes)
Mammalia NXF2B 35
  • 98.87 (n)
  • 97.68 (a)
rat
(Rattus norvegicus)
Mammalia Nxf2 35
  • 71.49 (n)
  • 58.89 (a)
Species with no ortholog for NXF2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NXF2B Gene

ENSEMBL:
Gene Tree for NXF2B (if available)
TreeFam:
Gene Tree for NXF2B (if available)

Paralogs for NXF2B Gene

Paralogs for NXF2B Gene

(5) SIMAP similar genes for NXF2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NXF2B: view

Variants for NXF2B Gene

Sequence variations from dbSNP and Humsavar for NXF2B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs491159 -- 102,399,787(+) GAACA(C/T)TGGTA intron-variant
rs493312 -- 102,388,923(+) gtcag(A/C)aagat intron-variant
rs498308 -- 102,440,588(+) ATGGT(C/G)TCCCT upstream-variant-2KB
rs500479 -- 102,381,722(-) AGTGT(C/T)AGGCT intron-variant
rs532182 -- 102,404,768(+) GCATT(A/T)GTGAA intron-variant

Relevant External Links for NXF2B Gene

HapMap Linkage Disequilibrium report
NXF2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NXF2B Gene

Disorders for NXF2B Gene

Relevant External Links for NXF2B

Genetic Association Database (GAD)
NXF2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXF2B
genes like me logo Genes that share disorders with NXF2B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXF2B Gene

Publications for NXF2B Gene

  1. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. (PMID: 16382448) Chen Y.-T. … Jongeneel C.V. (Genes Chromosomes Cancer 2006) 2 67
  2. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 67
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox C.S. … Atwood L.D. (BMC Med. Genet. 2007) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for NXF2B Gene

Sources for NXF2B Gene

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