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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXF2 Gene

protein-coding   GIFtS: 55
GCID: GC0XP101471

Nuclear RNA Export Factor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear RNA Export Factor 21 2     TAP-Like Protein 22 3
Cancer/Testis Antigen 391 2 3     TAP Like Protein 21
CT392 3     T-Complex Protein 11 Homolog2
TAPL-22 3     TAPL23

External Ids:    HGNC: 80721   Entrez Gene: 560012   Ensembl: ENSG000001855547   OMIM: 3003155   UniProtKB: Q9GZY03   

Export aliases for NXF2 gene to outside databases

Previous GC identifers: GC0XM096917 GC0XM098524 GC0XP099503 GC0XP100250 GC0XP101285 GC0XP101356 GC0XM091280


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NXF2 Gene:
This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the
nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located
adjacent on chromosome X and on the opposite strand. (provided by RefSeq, Aug 2013)

GeneCards Summary for NXF2 Gene: 
NXF2 (nuclear RNA export factor 2) is a protein-coding gene. Diseases associated with NXF2 include spermatocytoma, and pelizaeus-merzbacher disease, and among its related super-pathways are Influenza A. An important paralog of this gene is NXF1.

UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0
Function: Involved in the export of mRNA from the nucleus to the cytoplasm

Gene Wiki entry for NXF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NXF2 gene promoter:
         Sox5   STAT1   AML1a   STAT1beta   GATA-1   STAT1alpha   GCNF-1   HSF2   Cart-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NXF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

NXF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXF2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP101471:  view genomic region     (about GC identifiers)

Start:
101,470,280 bp from pter      End:
101,581,634 bp from pter
Size:
111,355 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0 (See protein sequence)
Recommended Name: Nuclear RNA export factor 2  
Size: 626 amino acids; 71627 Da
Subunit: Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear
envelope. Shuttles between the nucleus and the cytoplasm
Sequence caution: Sequence=AAK31975.1; Type=Erroneous initiation; Sequence=BAA91154.1; Type=Erroneous initiation;
Sequence=CAB75659.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to either
intron retention or a splicing event;
Secondary accessions: Q9BXU4 Q9NSS1 Q9NX66

Explore the universe of human proteins at neXtProt for NXF2: NX_Q9GZY0

Explore proteomics data for NXF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZY0

  • NXF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NXF2 Protein Expression
    REFSEQ proteins: NP_071336.1  
    ENSEMBL proteins: 
     ENSP00000361849   ENSP00000361844   ENSP00000361843   ENSP00000378523   ENSP00000331471  

    Human Recombinant Protein Products for NXF2: 
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    Novus Biologicals NXF2 Proteins
    Novus Biologicals NXF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NXF2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0015629actin cytoskeleton ----
    GO:0042272nuclear RNA export factor complex ----

    NXF2 for ontologies           About GeneDecksing



    NXF2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for NXF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR002075 NTF2
     IPR015245 Tap_RNA-bd
     IPR005637 TAP_C_dom
     IPR001611 Leu-rich_rpt
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9GZY0

    ProtoNet protein and cluster: Q9GZY0

    2 Blocks protein domains:
    IPB002075 Nuclear transport factor 2 (NTF2)
    IPB005637 TAP C-terminal domain


    UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0
    Domain: The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required
    for NXF2-mediated nuclear mRNA export
    Domain: The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus
    Domain: The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like
    domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary
    and sufficient for localization of NXF2 to the nuclear rim
    Domain: The RNA-binding domain is a non-canonical RNP-type domain
    Similarity: Belongs to the NXF family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 NTF2 domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 TAP-C domain


    NXF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXF2_HUMAN, Q9GZY0
    Function: Involved in the export of mRNA from the nucleus to the cytoplasm

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding ----
         
    NXF2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NXF2:
     Decreased viability with pacli 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nxf2):
     cellular  endocrine/exocrine gland  mortality/aging  no phenotypic analysis  reproductive system 

    NXF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nxf2tm1.2Jw for NXF2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NXF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NXF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NXF2 

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NXF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    2mRNA surveillance pathway
    mRNA surveillance pathway
    3Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes
    4RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5         Kegg Pathways  (Kegg details for NXF2):
        Ribosome biogenesis in eukaryotes
    RNA transport
    mRNA surveillance pathway
    Influenza A
    Herpes simplex infection


    NXF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NXF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/19 Interacting proteins for NXF2 (Q9GZY03 ENSP000003618434) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP214P356583, ENSP000003524004I2D: score=1 STRING: ENSP00000352400
    NUP153P497903, ENSP000002620774I2D: score=1 STRING: ENSP00000262077
    NUP62P371983, ENSP000003055034I2D: score=1 STRING: ENSP00000305503
    NXF2BENSP000003618354STRING: ENSP00000361835
    NXF3ENSP000003785044STRING: ENSP00000378504
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006406mRNA export from nucleus ----
    GO:0006810transport ----
    GO:0007275multicellular organismal development ----
    GO:0050658RNA transport ----
    GO:0051028mRNA transport ----

    NXF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXF2

    Search CenterWatch for drugs/clinical trials and news about NXF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NXF2 gene (3 alternative transcripts): 
    NM_022053.3  NM_001039910.1  NM_017809.3  

    Unigene Clusters for NXF2:

    Nuclear RNA export factor 2
    Hs.530358  [show with all ESTs], Hs.737538  [show with all ESTs]
    Unigene Representative Sequences: AL157436, AK093310
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372763(uc004eiw.4) ENST00000372758 ENST00000372757(uc004eix.4)
    ENST00000472029 ENST00000395088(uc004eiv.4 uc022cau.1) ENST00000330252(uc010noa.1)

    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF2

    Additional mRNA sequence: 

    AK093310.1 AK303069.1 AK307893.1 

    10 DOTS entries:

    DT.100661159  DT.103434  DT.95367446  DT.121307660  DT.40297652  DT.121288452  DT.121307672  DT.95341451 
    DT.121288456  DT.121307669 

    24/28 AceView cDNA sequences (see all 28):

    AK057385 BX647232 AX748046 AA932377 AF285596 AK000423 AL157436 AK093310 
    BG720848 AI028725 BQ934860 BM905182 AI221983 BU165622 AI203928 BI088001 
    BE894918 AA918605 BE621990 AA947908 BM172215 CB243869 AI208506 BE934341 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXF2 expression in normal human tissues (normalized intensities)      NXF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCAGCTC
    NXF2 Expression
    About this image


    NXF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
             sperm   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
             airway epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See NXF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXF2

    SOURCE GeneReport for Unigene clusters: Hs.530358 Hs.737538

    UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0
    Tissue specificity: Expressed almost exclusively in testis. Also expressed in several cancers

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NXF2 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxf25
    Nxf71
    nuclear RNA export factor 25
    nuclear RNA export factor 71
    69.35(n)1
    55(a)1
      X (56.31 cM)5
    1707221  NM_130888.11  NP_570958.11 
     1349445265 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    possible ortholog
    GL343739.1(136184-168794)
    zebrafish
    (Danio rerio)
    Actinopterygii CU468164.16
    nxf16
    (see all 4)
    nuclear RNA export factor 1
    (see all 4)
    46(a)
    43(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    14(9002608-9013043)
    21(26058501-26071321)
    fruit fly
    (Drosophila melanogaster)
    Insecta sbr3 poly(A)+ mRNA-nucleus export 27(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nxf-13 Leucine Rich Repeat (2 copies) 28(a)   V(14415218-14418389)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MEX676
    Poly(A)RNA binding protein involved in nuclear mRN...
    18(a)
    1 → many
    XVI(229039-230838)


    ENSEMBL Gene Tree for NXF2 (if available)
    TreeFam Gene Tree for NXF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXF2 gene
    NXF2B1 2  NXF12  NXF32  NXF52  
    5 SIMAP similar genes for NXF2 using alignment to 1 protein entry:     NXF2_HUMAN:
    NXF2B    NXF5    DKFZp667O0311    NXF1    NXF3

    NXF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NXF2
    PGOHUM00000241918


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 SNPs in NXF2 are shown (see all 227)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419006151,2
    C--91234121(+) ATCCCA/GGGCTT 1 -- us2k10--------
    rs1900693611,2
    C--91234222(+) CTGGGA/TTGTGT 1 -- us2k10--------
    rs1439633421,2
    C--91234655(+) TTAACA/GCTACC 1 -- us2k10--------
    rs48983301,2
    C,H--91234717(+) tcaaaG/Taactt 1 -- us2k17Minor allele frequency- T:0.00WA NA CSA 9
    rs1441844081,2
    --91234778(+) GTTATC/TCAATT 1 -- us2k10--------
    rs1473627511,2
    C--91234844(+) TGCACC/TGTGGT 1 -- us2k10--------
    rs1822379021,2
    --91234894(+) GAGAAA/GTGTTT 1 -- us2k10--------
    rs1401879951,2
    C--91235059(+) TCAGTC/TTTTGC 1 -- us2k10--------
    rs1864741791,2
    --91235129(+) AGTCCC/TTTTGA 1 -- us2k10--------
    rs1909507611,2
    --91235277(+) CTTCAC/TTGGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NXF2 (101470280 - 101581634 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NXF2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NXF2
    DNA2.0 Custom Variant and Variant Library Synthesis for NXF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300315    OMIM disorders: --

    8 diseases for NXF2:    About MalaCards
    spermatocytoma    pelizaeus-merzbacher disease    intellectual disability    male infertility
    short stature    infertility    influenza    mental retardation

    1 disease from the University of Copenhagen DISEASES database for NXF2:
    Male infertility

    NXF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NXF2

    Export disorders for NXF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXF2 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with NXF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PubMed id 11073998)1, 2, 3, 9 Herold A.... Izaurralde E. (2000)
    2. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (2001)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PubMed id 12704671)1, 2 Loriot A.... De Smet C. (2003)
    7. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. (PubMed id 11566096)1, 2 Jun L.... Froyen G. (2001)
    8. Familial 1.1 Mb deletion in chromosome Xq22.1 associa ted with mental retardation and behavioural disorders in female patients. (PubMed id 20096387)1, 9 Grillo L....Romano C. (2010)
    9. De novo duplication of Xq22.1->q24 with a disruption o f the NXF gene cluster in a mentally retarded woman with short stature and prema ture ovarian failure. (PubMed id 22030050)1 Chen C.P....Wang W. (2011)
    10. Chromosome X-encoded cancer/testis antigens show disti nctive expression patterns in developing gonads and in testicular seminoma. (PubMed id 22016418)1 Chen Y.T....Old L.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56001 HGNC: 8072 AceView: NXF2.1 Ensembl:ENSG00000185554 euGenes: HUgn56001
    ECgene: NXF2 Kegg: 56001 H-InvDB: NXF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NXF2 gene:
    Search GeneIP for patents involving NXF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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