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Aliases for NXF2 Gene

Aliases for NXF2 Gene

  • Nuclear RNA Export Factor 2 2 3 5
  • Cancer/Testis Antigen 39 2 3 4
  • TAP-Like Protein 2 3 4
  • TAPL-2 3 4
  • CT39 3 4
  • T-Complex Protein 11 Homolog 3
  • TAP Like Protein 2 2
  • NXF2 NXF2B 4
  • TCP11X2 3
  • TAPL2 4

External Ids for NXF2 Gene

Previous GeneCards Identifiers for NXF2 Gene

  • GC0XM096917
  • GC0XM098524
  • GC0XP099503
  • GC0XP100250
  • GC0XP101285
  • GC0XP101356
  • GC0XP101471
  • GC0XM091280

Summaries for NXF2 Gene

Entrez Gene Summary for NXF2 Gene

  • This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013]

GeneCards Summary for NXF2 Gene

NXF2 (Nuclear RNA Export Factor 2) is a Protein Coding gene. Among its related pathways are RNA transport and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is NXF2B.

UniProtKB/Swiss-Prot for NXF2 Gene

  • Involved in the export of mRNA from the nucleus to the cytoplasm.

Gene Wiki entry for NXF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXF2 Gene

Genomics for NXF2 Gene

Regulatory Elements for NXF2 Gene


Genomic Location for NXF2 Gene

Chromosome:
X
Start:
102,247,100 bp from pter
End:
102,326,720 bp from pter
Size:
79,621 bases
Orientation:
Plus strand

Genomic View for NXF2 Gene

Genes around NXF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXF2 Gene

Proteins for NXF2 Gene

  • Protein details for NXF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZY0-NXF2_HUMAN
    Recommended name:
    Nuclear RNA export factor 2
    Protein Accession:
    Q9GZY0
    Secondary Accessions:
    • Q9BXU4
    • Q9NSS1
    • Q9NX66

    Protein attributes for NXF2 Gene

    Size:
    626 amino acids
    Molecular mass:
    71627 Da
    Quaternary structure:
    • Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.
    • Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.
    SequenceCaution:
    • Sequence=AAK31975.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91154.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB75659.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to either intron retention or a splicing event.; Evidence={ECO:0000305};

neXtProt entry for NXF2 Gene

Proteomics data for NXF2 Gene at MOPED

Post-translational modifications for NXF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NXF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NXF2 Gene

Domains & Families for NXF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZY0

UniProtKB/Swiss-Prot:

NXF2_HUMAN :
  • The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.
  • Belongs to the NXF family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.
  • The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.
  • The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim.
  • The RNA-binding domain is a non-canonical RNP-type domain.
  • Contains 1 NTF2 domain.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 TAP-C domain.
Family:
  • Belongs to the NXF family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NXF2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NXF2 Gene

Function for NXF2 Gene

Molecular function for NXF2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the export of mRNA from the nucleus to the cytoplasm.

Gene Ontology (GO) - Molecular Function for NXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with NXF2: view

Phenotypes for NXF2 Gene

genes like me logo Genes that share phenotypes with NXF2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NXF2 Gene

Localization for NXF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXF2 Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXF2 Gene COMPARTMENTS Subcellular localization image for NXF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
genes like me logo Genes that share ontologies with NXF2: view

Pathways & Interactions for NXF2 Gene

genes like me logo Genes that share pathways with NXF2: view

Interacting Proteins for NXF2 Gene

Selected Interacting proteins: Q9GZY0-NXF2_HUMAN for NXF2 Gene via I2D

Gene Ontology (GO) - Biological Process for NXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0050658 RNA transport ISS --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with NXF2: view

No data available for SIGNOR curated interactions for NXF2 Gene

Drugs & Compounds for NXF2 Gene

No Compound Related Data Available

Transcripts for NXF2 Gene

mRNA/cDNA for NXF2 Gene

Unigene Clusters for NXF2 Gene

Nuclear RNA export factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NXF2 Gene

No ASD Table

Relevant External Links for NXF2 Gene

GeneLoc Exon Structure for
NXF2
ECgene alternative splicing isoforms for
NXF2

Expression for NXF2 Gene

mRNA expression in normal human tissues for NXF2 Gene

mRNA differential expression in normal tissues according to GTEx for NXF2 Gene

This gene is overexpressed in Testis (x23.6) and Pituitary (x10.7).

Protein differential expression in normal tissues from HIPED for NXF2 Gene

This gene is overexpressed in Testis (29.6), Urinary Bladder (27.1), and Ovary (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NXF2 Gene



SOURCE GeneReport for Unigene cluster for NXF2 Gene Hs.530358

mRNA Expression by UniProt/SwissProt for NXF2 Gene

Q9GZY0-NXF2_HUMAN
Tissue specificity: Expressed almost exclusively in testis. Also expressed in several cancers.
genes like me logo Genes that share expression patterns with NXF2: view

Protein tissue co-expression partners for NXF2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NXF2 Gene

Orthologs for NXF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NXF2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NXF2 35
  • 82.37 (n)
  • 73.72 (a)
mouse
(Mus musculus)
Mammalia Nxf2 35
  • 70.93 (n)
  • 57.85 (a)
chimpanzee
(Pan troglodytes)
Mammalia NXF2B 35
  • 98.87 (n)
  • 97.68 (a)
rat
(Rattus norvegicus)
Mammalia Nxf2 35
  • 71.49 (n)
  • 58.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta sbr 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea nxf-1 37
  • 28 (a)
Species with no ortholog for NXF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NXF2 Gene

ENSEMBL:
Gene Tree for NXF2 (if available)
TreeFam:
Gene Tree for NXF2 (if available)

Paralogs for NXF2 Gene

Paralogs for NXF2 Gene

(5) SIMAP similar genes for NXF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NXF2: view

Variants for NXF2 Gene

Sequence variations from dbSNP and Humsavar for NXF2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs13944 -- 102,326,490(-) GCCTC(C/T)GCGGG reference, synonymous-codon
rs480366 -- 102,297,473(+) actct(C/T)ggcct intron-variant
rs499306 -- 102,277,051(-) tcatt(A/C)atctt intron-variant
rs499851 -- 102,297,467(-) AGAGT(A/G)AACTT intron-variant
rs510766 -- 102,312,305(-) AGTGG(A/G)GAATC intron-variant

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for NXF2 Gene

Disorders for NXF2 Gene

Relevant External Links for NXF2

Genetic Association Database (GAD)
NXF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXF2

No disorders were found for NXF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NXF2 Gene

Publications for NXF2 Gene

  1. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PMID: 11073998) Herold A. … Izaurralde E. (Mol. Cell. Biol. 2000) 2 3 4 23 67
  2. Familial 1.1 Mb deletion in chromosome Xq22.1 associated with mental retardation and behavioural disorders in female patients. (PMID: 20096387) Grillo L. … Romano C. (Eur J Med Genet 2010) 3 23
  3. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  5. The cancera89testis antigen NXF2 is activated by the hypomethylating agent decitabine in acute leukemia cells in vitro and in vivo. (PMID: 24002123) Zhou J. … Yu L. (Mol Med Rep 2013) 3

Products for NXF2 Gene

Sources for NXF2 Gene

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