NXF2 Gene
protein-coding GIFtS: 54
GCID: GC0XP101471
|
|
nuclear RNA export factor 2
| |
Aliases
for NXF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear RNA Export Factor 21 2 | | TAP-Like Protein 22 3 | | CT391 2 3 | | T-Complex Protein 11 Homolog2 | | TAPL-21 2 3 | | TAPL23 | | Cancer/Testis Antigen 392 3 | | |
Export aliases for NXF2 gene to outside databasesPrevious GC identifers: GC0XM096917 GC0XM098524 GC0XP099503 GC0XP100250 GC0XP101285 GC0XP101356 GC0XM091280 |
Summaries
for NXF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NXF2:
This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export,is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a commonmechanism in this gene family. Two variants have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0Function: Involved in the export of mRNA from the nucleus to the cytoplasm
Gene Wiki entry for NXF2
|
Genomic Views
for NXF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NXF2 gene promoter:
Sox5 STAT1 AML1a STAT1beta GATA-1 STAT1alpha GCNF-1 HSF2 Cart-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NXF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1NXF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP101471: view genomic region
(about GC identifiers)
Start:
|
101,470,280 bp from pter |
End:
|
101,581,634 bp from pter |
Size:
|
111,355 bases |
Orientation:
|
plus strand |
|
Proteins
for NXF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0 (See
protein sequence)Recommended Name: Nuclear RNA export factor 2 Size: 626 amino acids; 71627 Da
Subunit: Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214
Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear envelope.Shuttles between the nucleus and the cytoplasm
Sequence caution: Sequence=AAK31975.1; Type=Erroneous initiation; Sequence=BAA91154.1; Type=Erroneous initiation;Sequence=CAB75659.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to either intronretention or a splicing event;
Secondary accessions: Q9BXU4 Q9NSS1 Q9NX66Explore the universe of human proteins at neXtProt for NXF2: NX_Q9GZY0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9GZY0
NXF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071336.1
ENSEMBL proteins: ENSP00000361849 ENSP00000361844 ENSP00000361843 ENSP00000378523 ENSP00000331471
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NXF2 for ontologies About GeneDecksing
NXF2 Antibody Products:
Assay Products for NXF2: |
Protein
Domains /
Families
for NXF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NXF2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9GZY0ProtoNet protein and cluster: Q9GZY0 2 Blocks protein families: IPB002075 Nuclear transport factor 2 (NTF2) IPB005637 TAP C-terminal domain
UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0Domain: The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required forNXF2-mediated nuclear mRNA exportDomain: The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleusDomain: The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-likedomain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary andsufficient for localization of NXF2 to the nuclear rimDomain: The RNA-binding domain is a non-canonical RNP-type domainSimilarity: Belongs to the NXF familySimilarity: Contains 4 LRR (leucine-rich) repeatsSimilarity: Contains 1 NTF2 domainSimilarity: Contains 1 RRM (RNA recognition motif) domainSimilarity: Contains 1 TAP-C domain |
Function
for NXF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0Function: Involved in the export of mRNA from the nucleus to the cytoplasm
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXF2 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NXF2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NXF2:
Animal Models:
Mouse knock-out Nxf2tm1.2Jw for NXF2
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Nxf2):
NXF2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NXF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA surveillance pathway | | | 2 | Ribosome biogenesis in eukaryotes | | | 3 | RNA transport | | | 4 | Measles | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Kegg Pathways (Kegg details for NXF2):
NXF2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NXF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/19 Interacting proteins for NXF2 (Q9GZY03 ENSP000003618434) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006406 | mRNA export from nucleus |
-- | -- | | GO:0007275 | multicellular organismal development |
-- | -- | | GO:0050658 | RNA transport |
-- | -- |
NXF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NXF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NXF2
Search CenterWatch for drugs/clinical trials and news about NXF2
|
Transcripts
for NXF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NXF2 gene (3 alternative transcripts): NM_022053.2 NM_001039910.1 NM_017809.3 Unigene Clusters for NXF2: Nuclear RNA export factor 2 Hs.530358 [show with all ESTs], Hs.737538 [show with all ESTs]Unigene Representative Sequences: AL157436, AK0933106 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372763(uc004eiw.4) ENST00000372758 ENST00000372757(uc004eix.4)
ENST00000472029 ENST00000395088(uc004eiv.4 uc022cau.1) ENST00000330252(uc010noa.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXF2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NXF2 (NM_017809) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF2 |
Additional cDNA sequence: AK093310.1 AK303069.1 AK307893.1 10 DOTS entries: DT.100661159 DT.103434 DT.95367446 DT.121307660 DT.40297652 DT.121288452 DT.121307672 DT.95341451 DT.121288456 DT.121307669 24/28 AceView cDNA sequences (see all 28): AK093310 BX647232 AK057385 AL157436 AK000423 AX748046 AF285596 AA932377 BI088001 BG720848 AI203928 AI221983 BU165622 AI028725 BQ934860 BM905182 BE894918 AA918605 BM172215 AA947908 BE621990 CB243869 AI208506 BE934341
GeneLoc Exon Structure
|
Expression
for NXF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NXF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTCAGCTC
About this image
See NXF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NXF2
SOURCE GeneReport for Unigene clusters: Hs.530358 Hs.737538
UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0Tissue specificity: Expressed almost exclusively in testis. Also expressed in several cancers
SABiosciences Custom PCR Arrays for NXF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXF2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NXF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF2 |
Orthologs
for NXF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NXF2 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
50(a) |
1 → many |
GL343739.1(139249-168794) |
zebrafish
(Danio rerio) |
Actinopterygii |
CU468164.26nxf16(see all 4) |
nuclear RNA export factor 1(see all 4) |
46(a)45(a)(see all 4) |
many ↔ manymany ↔ many(see all 4) |
14(9002608-9013043) 21(26058501-26071321) |
fruit fly
(Drosophila melanogaster) |
Insecta |
sbr3 |
poly(A)+ mRNA-nucleus export |
27(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
nxf-13 |
Leucine Rich Repeat (2 copies) |
28(a) |
|
V(14415218-14418389) -- |
ENSEMBL Gene Tree for NXF2 (if available)
TreeFam Gene Tree for NXF2 (if available) |
Paralogs
for NXF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NXF2 gene
- NXF2B1 2 NXF12 NXF32 NXF52
5 SIMAP similar genes for NXF2 using alignment to 1 protein entry: NXF2_HUMAN:NXF2B NXF5 DKFZp667O0311 NXF1 NXF3
NXF2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NXF2
PGOHUM00000241918
|
Genomic Variants
for NXF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NXF2 (101470280 - 101581634 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NXF2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXF2 |
|
Disorders
/ Diseases
for NXF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NXF2 for disorders About GeneDecksing
OMIM gene information: 300315
OMIM disorders: --
7  diseases for NXF2: About MalaCardspelizaeus-merzbacher disease spermatocytoma short stature intellectual disability
male infertility infertility influenza
2 diseases from the University of Copenhagen DISEASES database for NXF2:Male infertility Spermatocytoma Export disorders for NXF2 gene to outside databases
|
Publications
for NXF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NXF2 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with NXF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PubMed id 11073998)1, 2, 3, 9 Herold A.... Izaurralde E. (2000)
- An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (2001)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. (PubMed id 11566096)1, 2 Jun L.... Froyen G. (2001)
- Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. (PubMed id 10567585)1, 2 Black B.E.... Paschal B.M. (1999)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Is there a role for the nuclear export factor 2 gene in male infertility? (PubMed id 18258234)1 Stouffs K....Lissens W. (2008)
- Formation of a Tap/NXF1 Homotypic Complex Is Mediated through the Amino-Terminal Domain of Tap and Enhances Interaction with Nucleoporins. (PubMed id 17978099)1 Matzat L.H....Levesque L. (2008)
|
External Searches for NXF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NXF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NXF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NXF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NXF2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NXF2 gene:
Search GeneIP for patents involving NXF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NXF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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