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NXF2 Gene

protein-coding   GIFtS: 52
GCID: GC0XP101471

Nuclear RNA Export Factor 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear RNA Export Factor 21 2     TAP Like Protein 21
Cancer/Testis Antigen 391 2 3     TCP11X22
CT392 3     T-Complex Protein 11 Homolog2
TAPL-22 3     TAPL23
TAP-Like Protein 22 3     

External Ids:    HGNC: 80721   Entrez Gene: 560012   Ensembl: ENSG000001855547   OMIM: 3003155   UniProtKB: Q9GZY03   

Export aliases for NXF2 gene to outside databases

Previous GC identifers: GC0XM096917 GC0XM098524 GC0XP099503 GC0XP100250 GC0XP101285 GC0XP101356 GC0XM091280


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NXF2 Gene:
This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the
nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located
adjacent on chromosome X and on the opposite strand. (provided by RefSeq, Aug 2013)

GeneCards Summary for NXF2 Gene:
NXF2 (nuclear RNA export factor 2) is a protein-coding gene. An important paralog of this gene is NXF1.

UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0
Function: Involved in the export of mRNA from the nucleus to the cytoplasm

Gene Wiki entry for NXF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NXF2 gene promoter:
         Sox5   STAT1   AML1a   STAT1beta   GATA-1   STAT1alpha   GCNF-1   HSF2   Cart-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXF2 promoter sequence
   Search Chromatin IP Primers for NXF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NXF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.1   Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

NXF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXF2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP101471:  view genomic region     (about GC identifiers)

Start:
101,470,280 bp from pter      End:
101,581,634 bp from pter
Size:
111,355 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0 (See protein sequence)
Recommended Name: Nuclear RNA export factor 2  
Size: 626 amino acids; 71627 Da
Subunit: Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214
Sequence caution: Sequence=AAK31975.1; Type=Erroneous initiation; Sequence=BAA91154.1; Type=Erroneous initiation;
Sequence=CAB75659.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown due to either
intron retention or a splicing event;
Secondary accessions: Q9BXU4 Q9NSS1 Q9NX66

Explore the universe of human proteins at neXtProt for NXF2: NX_Q9GZY0

Explore proteomics data for NXF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NXF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071336.1  
    ENSEMBL proteins: 
     ENSP00000361849   ENSP00000361844   ENSP00000361843   ENSP00000378523   ENSP00000331471  

    NXF2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NXF2

     
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    Search eBioscience for ELISAs for NXF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR002075 NTF2
     IPR015245 Tap_RNA-bd
     IPR005637 TAP_C_dom
     IPR001611 Leu-rich_rpt
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9GZY0

    ProtoNet protein and cluster: Q9GZY0

    2 Blocks protein domains:
    IPB002075 Nuclear transport factor 2 (NTF2)
    IPB005637 TAP C-terminal domain


    UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0
    Domain: The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required
    for NXF2-mediated nuclear mRNA export
    Domain: The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus
    Domain: The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like
    domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary
    and sufficient for localization of NXF2 to the nuclear rim
    Domain: The RNA-binding domain is a non-canonical RNP-type domain
    Similarity: Belongs to the NXF family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 NTF2 domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 TAP-C domain


    Find genes that share domains with NXF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXF2_HUMAN, Q9GZY0
    Function: Involved in the export of mRNA from the nucleus to the cytoplasm

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NXF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NXF2:
     Decreased viability with pacli 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nxf2):
     cellular  endocrine/exocrine gland  mortality/aging  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with NXF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nxf2tm1.2Jw for NXF2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NXF2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXF2
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    GenScript: all cDNA clones in your preferred vector (see all 2): NXF2 (NM_017809)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NXF2_HUMAN, Q9GZY0: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in the nucleoplasm and at the nuclear
    envelope. Shuttles between the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0015629actin cytoskeleton ----
    GO:0042272nuclear RNA export factor complex ----

    Find genes that share ontologies with NXF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NXF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    2RNA transport
    RNA transport
    3Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes
    4mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with NXF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Kegg Pathways  (Kegg details for NXF2):
        Ribosome biogenesis in eukaryotes
    RNA transport
    mRNA surveillance pathway
    Influenza A
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NXF2
    Interactions:

        GeneGlobe Interaction Network for NXF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NXF2 (Q9GZY03 ENSP000003618434) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP214P356583, ENSP000003524004I2D: score=1 STRING: ENSP00000352400
    NUP153P497903, ENSP000002620774I2D: score=1 STRING: ENSP00000262077
    NUP62P371983, ENSP000003055034I2D: score=1 STRING: ENSP00000305503
    NXF3ENSP000003785044STRING: ENSP00000378504
    NXF2BENSP000003618354STRING: ENSP00000361835
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    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006406mRNA export from nucleus ----
    GO:0006810transport ----
    GO:0007275multicellular organismal development ----
    GO:0050658RNA transport ----
    GO:0051028mRNA transport ----

    Find genes that share ontologies with NXF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NXF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NXF2 gene (3 alternative transcripts): 
    NM_022053.3  NM_001039910.1  NM_017809.3  

    Unigene Cluster for NXF2:

    Nuclear RNA export factor 2
    Hs.530358  [show with all ESTs]
    Unigene Representative Sequence: AL157436
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372763(uc004eiw.4) ENST00000372758 ENST00000372757(uc004eix.4)
    ENST00000472029 ENST00000395088(uc004eiv.4 uc022cau.1) ENST00000330252(uc010noa.1)

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NXF2
      QuantiFast Probe-based Assays in human, mouse, rat NXF2

    Additional mRNA sequence: 

    AJ277526.1 AJ277659.1 AK057385.1 AL157436.1 BC015020.1 

    10 DOTS entries:

    DT.100661159  DT.103434  DT.95367446  DT.121288452  DT.121288456  DT.121307669  DT.121307672  DT.95341451 
    DT.121307660  DT.40297652 

    Selected AceView cDNA sequences (see all 28):

    AX748046 AK000423 AF285596 AA932377 AL157436 AK093310 AK057385 BX647232 
    BM905182 AI221983 BE894918 AI028725 BQ934860 BI088001 BG720848 BU165622 
    AI203928 BE621990 AA918605 AA947908 BM172215 CB243869 AI208506 BE934341 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NXF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCAGCTC
    NXF2 Expression
    About this image

    NXF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NXF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530358

    UniProtKB/Swiss-Prot: NXF2_HUMAN, Q9GZY0
    Tissue specificity: Expressed almost exclusively in testis. Also expressed in several cancers

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NXF2 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxf21 , 5 nuclear RNA export factor 21, 5 70.93(n)1
    57.85(a)1
      X (56.31 cM)5
    834541  NM_031259.11  NP_112549.11 
     1349445265 
    fruit fly
    (Drosophila melanogaster)
    Insecta sbr3 poly(A)+ mRNA-nucleus export 27(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea nxf-13 Leucine Rich Repeat (2 copies) 28(a)   V(14415218-14418389)   --


    ENSEMBL Gene Tree for NXF2 (if available)
    TreeFam Gene Tree for NXF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NXF2 gene
    NXF2B1 2  NXF12  NXF32  NXF52  
    5 SIMAP similar genes for NXF2 using alignment to 1 protein entry:     NXF2_HUMAN:
    NXF2B    NXF5    DKFZp667O0311    NXF1    NXF3

    Find genes that share paralogs with NXF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NXF2
    PGOHUM00000241918


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NXF2 (see all 227)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419006151,2
    C--91234121(+) ATCCCA/GGGCTT 1 -- us2k10--------
    rs1900693611,2
    C--91234222(+) CTGGGA/TTGTGT 1 -- us2k10--------
    rs1439633421,2
    C--91234655(+) TTAACA/GCTACC 1 -- us2k10--------
    rs48983301,2
    C,H--91234717(+) tcaaaG/Taactt 1 -- us2k17Minor allele frequency- T:0.00WA NA CSA 9
    rs1441844081,2
    --91234778(+) GTTATC/TCAATT 1 -- us2k10--------
    rs1473627511,2
    C--91234844(+) TGCACC/TGTGGT 1 -- us2k10--------
    rs1822379021,2
    --91234894(+) GAGAAA/GTGTTT 1 -- us2k10--------
    rs1401879951,2
    C--91235059(+) TCAGTC/TTTTGC 1 -- us2k10--------
    rs1864741791,2
    --91235129(+) AGTCCC/TTTTGA 1 -- us2k10--------
    rs1909507611,2
    --91235277(+) CTTCAC/TTGGTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NXF2 (101470280 - 101581634 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NXF2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NXF2
    DNA2.0 Custom Variant and Variant Library Synthesis for NXF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300315    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NXF2:
    Male infertility

    Find genes that share disorders with NXF2           About GenesLikeMe

    Genetic Association Database (GAD): NXF2

    Export disorders for NXF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NXF2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with NXF2)
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    1. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. (PubMed id 11073998)1, 2, 3, 9 Herold A.... Izaurralde E. (Mol. Cell. Biol. 2000)
    2. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (Nat. Genet. 2001)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PubMed id 12704671)1, 2 Loriot A.... De Smet C. (Int. J. Cancer 2003)
    7. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. (PubMed id 11566096)1, 2 Jun L.... Froyen G. (Curr. Biol. 2001)
    8. Familial 1.1 Mb deletion in chromosome Xq22.1 associated with mental retardation and behavioural disorders in female patients. (PubMed id 20096387)1, 9 Grillo L....Romano C. (Eur J Med Genet 2010)
    9. De novo duplication of Xq22.1a89q24 with a disruption of the NXF gene cluster in a mentally retarded woman with short stature and premature ovarian failure. (PubMed id 22030050)1 Chen C.P....Wang W. (amp 2011)
    10. Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma. (PubMed id 22016418)1 Chen Y.T....Old L.J. (Hum. Reprod. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56001 HGNC: 8072 AceView: NXF2.1 Ensembl:ENSG00000185554 euGenes: HUgn56001
    ECgene: NXF2 Kegg: 56001 H-InvDB: NXF2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NXF2 Pharmacogenomics, SNPs, Pathways

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