Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NXF1 Gene

Aliases for NXF1 Gene

  • Nuclear RNA Export Factor 1 2 3
  • TAP 3 4 6
  • Tip Associating Protein 2 3
  • Tip-Associating Protein 3 4
  • Tip-Associated Protein 3 4
  • MRNA Export Factor TAP 3 4
  • MEX67 3 6

External Ids for NXF1 Gene

Previous GeneCards Identifiers for NXF1 Gene

  • GC11M065072
  • GC11M064135
  • GC11M062810
  • GC11M062335
  • GC11M062316
  • GC11M062559
  • GC11M058888

Summaries for NXF1 Gene

Entrez Gene Summary for NXF1 Gene

  • This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NXF1 Gene

NXF1 (Nuclear RNA Export Factor 1) is a Protein Coding gene. Diseases associated with NXF1 include branchiootorenal syndrome and genital herpes. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include nucleotide binding and nucleocytoplasmic transporter activity. An important paralog of this gene is NXF5.

UniProtKB/Swiss-Prot for NXF1 Gene

  • Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.

Gene Wiki entry for NXF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXF1 Gene

Genomics for NXF1 Gene

Regulatory Elements for NXF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NXF1 Gene

Start:
62,792,123 bp from pter
End:
62,806,302 bp from pter
Size:
14,180 bases
Orientation:
Minus strand

Genomic View for NXF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NXF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXF1 Gene

Proteins for NXF1 Gene

  • Protein details for NXF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU9-NXF1_HUMAN
    Recommended name:
    Nuclear RNA export factor 1
    Protein Accession:
    Q9UBU9
    Secondary Accessions:
    • B4E269
    • Q99799
    • Q9UQL2

    Protein attributes for NXF1 Gene

    Size:
    619 amino acids
    Molecular mass:
    70182 Da
    Quaternary structure:
    • Heterodimer with NXT1. Interacts (via NTF2 domain) with NXT1. The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export. Interacts with NXT2, E1B-AP5, RAE1, ALYREF/THOC4, DDX39B, FYTTD1/UIF, EIF4A3, NUPL2 and with several nucleoporins. Interacts with THOC5 and CHTOP; in a mutually exclusive manner. Associates with the exon junction complex (EJC) and with the transcription/export (TREX) complex. Found in a mRNA complex with RENT3A and RENT3B. Interacts with Saimiriine herpesvirus 2 TIP protein. Interacts with human herpes virus 1 (HHV-1) ICP27 protein; this interaction allows efficient export of HHV-1 early and late transcripts. Interacts with FRG1 (via N-terminus).

    Three dimensional structures from OCA and Proteopedia for NXF1 Gene

    Alternative splice isoforms for NXF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXF1 Gene

Proteomics data for NXF1 Gene at MOPED

Post-translational modifications for NXF1 Gene

  • Ubiquitination at Lys117, Lys173, and Lys230
  • Modification sites at PhosphoSitePlus

Other Protein References for NXF1 Gene

No data available for DME Specific Peptides for NXF1 Gene

Domains for NXF1 Gene

Suggested Antigen Peptide Sequences for NXF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBU9

UniProtKB/Swiss-Prot:

NXF1_HUMAN :
  • Q9UBU9
Domain:
  • The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats.
  • The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs.
  • The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from the nucleus. It inhibits RNA binding activity through an intramolecular interaction with the N-terminal RNA binding domain (RBD); the inhibition is removed by an association with the TREX complex, specifically involving ALYREF/THOC4 and THOC5.
  • The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in the interaction with nucleoporins.
  • The leucine-rich repeats are essential for the export of mRNA from the nucleus.
  • The RNA-binding domain is a non-canonical RNP-type domain.
  • Contains 1 NTF2 domain.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 TAP-C domain.
Family:
  • Belongs to the NXF family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NXF1: view

No data available for Gene Families for NXF1 Gene

Function for NXF1 Gene

Molecular function for NXF1 Gene

UniProtKB/Swiss-Prot Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.

Gene Ontology (GO) - Molecular Function for NXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding --
GO:0003729 mRNA binding IEA --
GO:0005487 nucleocytoplasmic transporter activity IEA --
GO:0005515 protein binding IPI 10924507
genes like me logo Genes that share ontologies with NXF1: view
genes like me logo Genes that share phenotypes with NXF1: view

Animal Model Products

CRISPR Products

miRNA for NXF1 Gene

miRTarBase miRNAs that target NXF1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NXF1 Gene

Localization for NXF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXF1 Gene

Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXF1 Gene COMPARTMENTS Subcellular localization image for NXF1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 colocalizes_with transcription export complex IDA 23299939
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with NXF1: view

Pathways for NXF1 Gene

genes like me logo Genes that share pathways with NXF1: view

Gene Ontology (GO) - Biological Process for NXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006405 RNA export from nucleus --
GO:0006406 mRNA export from nucleus TAS --
GO:0006810 transport --
GO:0010467 gene expression TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with NXF1: view

Compounds for NXF1 Gene

(3) Novoseek inferred chemical compound relationships for NXF1 Gene

Compound -log(P) Hits PubMed IDs
arginine 12.6 4
serine 7.58 1
atp 0 2
genes like me logo Genes that share compounds with NXF1: view

Transcripts for NXF1 Gene

Unigene Clusters for NXF1 Gene

Nuclear RNA export factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NXF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - -
SP2:
SP3: - - - - - - - - - - - - - - - - - -
SP4:
SP5: - -
SP6:
SP7: - - -
SP8: - - - -
SP9:
SP10: - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12:

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NXF1 Gene

GeneLoc Exon Structure for
NXF1
ECgene alternative splicing isoforms for
NXF1

Expression for NXF1 Gene

mRNA expression in normal human tissues for NXF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NXF1 Gene

SOURCE GeneReport for Unigene cluster for NXF1 Gene Hs.523739

mRNA Expression by UniProt/SwissProt for NXF1 Gene

Q9UBU9-NXF1_HUMAN
Tissue specificity: Expressed ubiquitously
genes like me logo Genes that share expressions with NXF1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NXF1 Gene

Orthologs for NXF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NXF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXF1 35
  • 99.73 (n)
  • 100 (a)
NXF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NXF1 35
  • 88.3 (n)
  • 93.2 (a)
NXF1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXF1 35
  • 90.08 (n)
  • 94.66 (a)
NXF1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nxf1 35
  • 87.54 (n)
  • 91.26 (a)
Nxf1 16
Nxf1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NXF1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxf1 35
  • 88.13 (n)
  • 92.07 (a)
lizard
(Anolis carolinensis)
Reptilia NXF1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxf1 35
  • 63.96 (n)
  • 62.76 (a)
Str.6094 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2787 35
zebrafish
(Danio rerio)
Actinopterygii mgab03e05 35
nxf1 35
  • 62.47 (n)
  • 64.05 (a)
nxf1 36
  • 61 (a)
OneToMany
NXF1 (2 of 4) 36
  • 49 (a)
OneToMany
NXF1 (3 of 4) 36
  • 49 (a)
OneToMany
NXF1 (4 of 4) 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002193 35
  • 48.98 (n)
  • 41.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta nxf2 36
  • 16 (a)
ManyToMany
Nxf3 36
  • 21 (a)
ManyToMany
sbr 35
  • 45.78 (n)
  • 37.35 (a)
sbr 36
  • 29 (a)
ManyToMany
sbr 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea nxf-1 36
  • 25 (a)
ManyToMany
nxf-2 35
  • 43.18 (n)
  • 32.16 (a)
nxf-2 36
  • 26 (a)
ManyToMany
nxf-1 37
  • 27 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL104C 35
  • 41.12 (n)
  • 29.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEX67 35
  • 37.68 (n)
  • 29.44 (a)
MEX67 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09801g 35
  • 38.55 (n)
  • 28.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mex67 35
  • 42.42 (n)
  • 31.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for NXF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXF1 Gene

ENSEMBL:
Gene Tree for NXF1 (if available)
TreeFam:
Gene Tree for NXF1 (if available)

Paralogs for NXF1 Gene

Paralogs for NXF1 Gene

Selected SIMAP similar genes for NXF1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NXF1: view

Variants for NXF1 Gene

Sequence variations from dbSNP and Humsavar for NXF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4693 -- 62,796,537(-) GACCG(A/G)CAAGG utr-variant-3-prime, reference, synonymous-codon
rs489275 -- 62,799,911(+) CTTGG(C/T)GCAAG utr-variant-3-prime, intron-variant
rs490791 -- 62,803,673(+) TAATC(A/C)CTAAG intron-variant
rs529220 -- 62,806,009(-) AAATA(C/T)ATGTT upstream-variant-2KB
rs539465 -- 62,795,881(-) AGTCC(C/T)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXF1 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
nsv897624 CNV Loss 21882294

Relevant External Links for NXF1 Gene

HapMap Linkage Disequilibrium report
NXF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXF1 Gene

Disorders for NXF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NXF1 Gene including...

Search for NXF1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NXF1 Gene

(4) Novoseek inferred disease relationships for NXF1 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 7.77 4
virus infection 0 1
hepatocellular carcinoma 0 1
tumors 0 2
genes like me logo Genes that share disorders with NXF1: view

No data available for UniProtKB/Swiss-Prot for NXF1 Gene

Publications for NXF1 Gene

  1. Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. (PMID: 9175835) Yoon D.-W. … Jung J.U. (Immunity 1997) 2 3 4 23
  2. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. (PMID: 9660949) Grueter P. … Izaurralde E. (Mol. Cell 1998) 2 3 4 23
  3. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. (PMID: 10202158) Braun I.C. … Izaurralde E. (EMBO J. 1999) 3 4 23
  4. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. (PMID: 10228171) Katahira J. … Hurt E. (EMBO J. 1999) 3 4 23
  5. The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain. (PMID: 11060011) Liker E. … Conti E. (EMBO J. 2000) 3 4 23

Products for NXF1 Gene

Sources for NXF1 Gene

Back to Top

Content