NXF1 Gene
protein-coding GIFtS: 62
GCID: GC11M062559
|
|
nuclear RNA export factor 1
| |
Aliases
for NXF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nuclear RNA Export Factor 11 2 | | MEX672 5 | | TAP1 2 3 5 | | DKFZp667O03111 | | Tip-Associated Protein2 3 | | Mex671 | | Tip-Associating Protein2 3 | | Tip Associating Protein2 | | MRNA Export Factor TAP2 3 | | |
Export aliases for NXF1 gene to outside databasesPrevious GC identifers: GC11M065072 GC11M064135 GC11M062810 GC11M062335 GC11M062316 GC11M058888 |
Summaries
for NXF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NXF1:
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are anoncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2(NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and aubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are requiredfor export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein ofthis gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebratehomologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence ofsaturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results inmultiple transcript variants. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) andin the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70mRNA in conjunction with ALYREF/THOC4 and THOC5
Gene Wiki entry for NXF1
|
Genomic Views
for NXF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NXF1 gene promoter:
AML1a Bach2 NRSF form 1 HNF-1 ARP-1 NRSF form 2 GATA-2 HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for NXF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12-q13 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12-q13NXF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M062559: view genomic region
(about GC identifiers)
Start:
|
62,559,598 bp from pter |
End:
|
62,573,774 bp from pter |
Size:
|
14,177 bases |
Orientation:
|
minus strand |
|
Proteins
for NXF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9 (See
protein sequence)Recommended Name: Nuclear RNA export factor 1 Size: 619 amino acids; 70182 Da
Subunit: Heterodimer with NXT1. Interacts (via NTF2 domain) with NXT1. The formation of NXF1/NXT1 heterodimers isrequired for the NXF1-mediated nuclear mRNA export. Interacts with NXT2, E1B-AP5, RAE1, ALYREF/THOC4 and with severalnucleoporins. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF1,UPF2, UPF3A, UPF3B, ALYREF/THOC4 and/or REFBP2. Found in a mRNA complex with RENT3A and RENT3B. Interacts withFYTTD1/UIF, EIF4A3, NUPL2 and THOC5. Interacts with Saimiriine herpesvirus 2 TIP protein. Interacts with human herpesvirus 1 (HHV-1) ICP27 protein; this interaction allows efficient export of HHV-1 early and late transcripts
Subcellular location: Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the nucleoplasmand at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and thecytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA
6/12 PDB 3D structures from  and Proteopedia  for NXF1 (see all 12):1FO1 (3D)
1FT8 (3D)
1GO5 (3D)
1JKG (3D)
1JN5 (3D)
1KOH (3D)
Secondary accessions: B4E269 Q99799 Q9UQL2Alternative splicing: 2 isoforms: Q9UBU9-1 Q9UBU9-2 Explore the universe of human proteins at neXtProt for NXF1: NX_Q9UBU9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBU9
NXF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001074960.1 NP_006353.2
ENSEMBL proteins: ENSP00000453885 ENSP00000436679 ENSP00000434301 ENSP00000435742 ENSP00000431381 ENSP00000432530 ENSP00000437296 ENSP00000294172 ENSP00000408864 Reactome Protein details: Q9UBU9
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
NXF1 for ontologies About GeneDecksing
NXF1 Antibody Products:
Assay Products for NXF1: |
Protein
Domains /
Families
for NXF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NXF1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9UBU9ProtoNet protein and cluster: Q9UBU9 4 Blocks protein families: IPB001611 Leucine-rich repeat signature IPB002075 Nuclear transport factor 2 (NTF2) IPB003603 Leucine-rich-associated IPB005637 TAP C-terminal domain
UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9Domain: The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeatsDomain: The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain(also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in theTAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAsDomain: The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from thenucleusDomain: The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient forlocalization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in theinteraction with nucleoporinsDomain: The leucine-rich repeats are essential for the export of mRNA from the nucleusDomain: The RNA-binding domain is a non-canonical RNP-type domainSimilarity: Belongs to the NXF familySimilarity: Contains 4 LRR (leucine-rich) repeatsSimilarity: Contains 1 NTF2 domainSimilarity: Contains 1 RRM (RNA recognition motif) domainSimilarity: Contains 1 TAP-C domain |
Function
for NXF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) andin the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70mRNA in conjunction with ALYREF/THOC4 and THOC5
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXF1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NXF1 (NM_001081491) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
NXF1 for ontologies About GeneDecksing
14 GenomeRNAi human phenotypes for NXF1:
Animal Models:
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Nxf1):
NXF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NXF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | Transport of the SLBP independent Mature mRNA | | | 3 | Transport of Mature mRNA Derived from an Intronless Transcript | | | 4 | Transport of Mature Transcript to Cytoplasm | | | 5 | mRNA surveillance pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for NXF1
5/9 
Reactome Pathways for NXF1 (see all 9)
4 
Kegg Pathways (Kegg details for NXF1):
NXF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NXF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/118 Interacting proteins for NXF1 (Q9UBU91, 2, 3 ENSP000002941724) via UniProtKB, MINT, STRING, and/or I2D (see all 118)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SRSF7 | Q166292, 3, ENSP000003259054 | MINT-3380010 MINT-3380040 MINT-3380069 I2D:
score=4 STRING: ENSP00000325905 | | RAE1 | P784062, 3, ENSP000003602864 | MINT-14382 MINT-14383 I2D:
score=3 STRING: ENSP00000360286 | | NUP98 | P529482, 3, ENSP000003160324 | MINT-15768 I2D:
score=4 STRING: ENSP00000316032 | | NUP214 | P356582, 3, ENSP000003524004 | MINT-15076 I2D:
score=3 STRING: ENSP00000352400 | | SRSF1 | Q079551, 3, ENSP000002589624 | EBI-398874,EBI-398920 I2D:
score=3 STRING: ENSP00000258962 |
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
NXF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NXF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NXF1 for compounds About GeneDecksing
 Browse Tocris compounds for NXF1
3 Novoseek chemical compound relationships for NXF1 gene About this table
Search CenterWatch for drugs/clinical trials and news about NXF1
|
Transcripts
for NXF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NXF1 gene (2 alternative transcripts): NM_001081491.1 NM_006362.4 Unigene Cluster for NXF1: Nuclear RNA export factor 1 Hs.523739 [show with all ESTs]Unigene Representative Sequence: NM_00108149118 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531709(uc001nvg.1 uc010rmh.1) ENST00000532297 ENST00000527902
ENST00000533048 ENST00000533499 ENST00000527497 ENST00000530875(uc009yog.1)
ENST00000533440 ENST00000531872 ENST00000531579 ENST00000526163 ENST00000531131
ENST00000533671 ENST00000525576 ENST00000531474 ENST00000527064 ENST00000294172(uc001nvf.1)
ENST00000439713
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXF1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NXF1 (NM_001081491) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NXF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF1 |
Additional cDNA sequence: AB209915.1 AF112880.1 AF126246.1 AJ132712.1 AK027192.1 AK304082.1 AK304137.1 AK304743.1 AK307961.1 AK307998.1 BC004904.2 BC017421.1 BC028041.1 CR749674.1 U80073.1 Z36505.1 24/30 DOTS entries (see all 30): DT.100643758 DT.100648210 DT.99934843 DT.120700981 DT.101983229 DT.40269943 DT.40286116 DT.100648211 DT.120700997 DT.91741762 DT.120700962 DT.97795449 DT.100648213 DT.120700941 DT.120700951 DT.120701041 DT.121430873 DT.40132239 DT.91667990 DT.95092191 DT.95092203 DT.120700933 DT.120700998 DT.120701010 24/617 AceView cDNA sequences (see all 617): BQ446225 AI922299 AI268362 BX410198 BG236316 BM844329 BI062712 AI088461 BU616344 BC017421 CA310153 CA487229 U80073 BM756732 AV652902 BM766761 BQ670320 CR597811 BM771024 AI672668 BC004904 BM770218 BQ722357 AI394581
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for NXF1 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | - | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NXF1
|
Expression
for NXF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NXF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCAGAAGC
About this image
See NXF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NXF1
SOURCE GeneReport for Unigene cluster: Hs.523739
UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9Tissue specificity: Expressed ubiquitously
SABiosciences Custom PCR Arrays for NXF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NXF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF1 |
Orthologs
for NXF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for NXF1 gene from 6/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
66(a) |
1 → many |
GL343739.1(139249-168794) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CB591324.12 |
-- |
73.19(n) |
|
CB591324.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mgab03e052 |
mgab03e05 |
71.4(n) |
|
326948 BG727737.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
sbr1 , 3 |
poly(A)+ mRNA-nucleus export3
small bristles1 |
32(a)3
45.22(n)1
36(a)1 |
|
439441 NM_079921.31 NP_524660.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
nxf-13
nxf-21 |
Leucine Rich Repeat (2 copies)3
Protein NXF-21 |
27(a)3
42.95(n)1
32.29(a)1 |
|
V(14415218-14418389)3
1799381 NM_074167.51 NP_506568.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
MEX67(YPL169C)4
MEX671 |
Poly(A)RNA binding protein involved in nuclear mRNA more4
Mex67p1 |
37.16(n)1
27.46(a)1 |
|
16(230838-229039)4
8559341, 4 NP_015156.11, 4 |
ENSEMBL Gene Tree for NXF1 (if available)
TreeFam Gene Tree for NXF1 (if available) |
Paralogs
for NXF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NXF1 gene
- NXF32 NXF2B2 NXF22 NXF52
5 SIMAP similar genes for NXF1 using alignment to 6 protein entries: NXF1_HUMAN (see all proteins):DKFZp667O0311 NXF2B NXF2 NXF3 NXF5
NXF1 for paralogs About GeneDecksing
|
Genomic Variants
for NXF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NXF1 (62559598 - 62573774 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NXF1
1 CNV: 0150 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXF1 |
|
Disorders
/ Diseases
for NXF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NXF1 for disorders About GeneDecksing
OMIM gene information: 602647
OMIM disorders: --
20  diseases for NXF1: About MalaCardsgenital herpes branchiootorenal syndrome intellectual disability chickenpox
herpes simplex kaposi's sarcoma myeloid malignancy graves' disease
hepatocellular carcinoma embryonal carcinoma hepatitis c conjunctivitis
sarcoma influenza immunodeficiency carcinoma
ataxia hepatitis melanoma neuronitis
1 disease from the University of Copenhagen DISEASES database for NXF1:Branchiootorenal syndrome 4 Novoseek disease relationships for NXF1 gene About this table
Export disorders for NXF1 gene to outside databases
|
Publications
for NXF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NXF1 gene, integrated from 9 sources (see all 135):
(articles sorted by number of sources associating them with NXF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. (PubMed id 9660949)1, 2, 3, 9 Gruter P....Izaurralde E. (1998)
- Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. (PubMed id 9175835)1, 2, 3, 9 Yoon D.-W.... Jung J.U. (1997)
- TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. (PubMed id 10202158)1, 2, 9 Braun I.C.... Izaurralde E. (1999)
- Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. (PubMed id 11259411)1, 2, 9 Braun I.C.... Izaurralde E. (2001)
- The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain. (PubMed id 11060011)1, 2, 9 Liker E.... Conti E. (2000)
- The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. (PubMed id 10228171)1, 2, 9 Katahira J....Hurt E. (1999)
- Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. (PubMed id 11583626)1, 2, 9 Fribourg S.... Conti E. (2001)
- Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. (PubMed id 19165146)1, 2, 9 Katahira J.... Yoneda Y. (2009)
- Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolution. (PubMed id 12581645)1, 2, 9 Grant R.P.... Stewart M. (2003)
- Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. (PubMed id 11707413)1, 2, 9 Kataoka N.... Dreyfuss G. (2001)
|
External Searches for NXF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NXF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NXF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NXF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NXF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NXF1 gene:
Search GeneIP for patents involving NXF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NXF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NXF1 | | OriGene shRNA RFP for NXF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NXF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NXF1 | | | OriGene Protein Over-expression Lysate for NXF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NXF1 | | OriGene 3'-UTR Clone for NXF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NXF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NXF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NXF1 | | OriGene Custom Protein Services for NXF1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NXF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NXF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NXF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NXF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NXF1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for NXF1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | NXF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF1 |
|  |  |  | | | | ThermoFisher Antibody for NXF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NXF1 |
|
|
|
|
