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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NXF1 Gene

protein-coding   GIFtS: 62
GCID: GC11M062559

Nuclear RNA Export Factor 1

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear RNA Export Factor 11 2     Tip-Associating Protein2 3
TAP2 3 5     MRNA Export Factor TAP2 3
Tip Associating Protein1 2     MEX672 5
Tip-Associated Protein2 3     

External Ids:    HGNC: 80711   Entrez Gene: 104822   Ensembl: ENSG000001622317   OMIM: 6026475   UniProtKB: Q9UBU93   

Export aliases for NXF1 gene to outside databases

Previous GC identifers: GC11M065072 GC11M064135 GC11M062810 GC11M062335 GC11M062316 GC11M058888


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NXF1 Gene:
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are
a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2
(NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a
ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are
required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The
encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It
is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block
caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for NXF1 Gene: 
NXF1 (nuclear RNA export factor 1) is a protein-coding gene. Diseases associated with NXF1 include branchiootorenal syndrome, and genital herpes, and among its related super-pathways are mRNA Processing and Transport of Mature mRNAs Derived from Intronless Transcripts. GO annotations related to this gene include nucleocytoplasmic transporter activity and nucleotide binding. An important paralog of this gene is NXF3.

UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9
Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE)
and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export
of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5

Gene Wiki entry for NXF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NXF1 gene promoter:
         AML1a   Bach2   NRSF form 1   HNF-1   ARP-1   NRSF form 2   GATA-2   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNXF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NXF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NXF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12-q13

NXF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NXF1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062559:  view genomic region     (about GC identifiers)

Start:
62,559,595 bp from pter      End:
62,573,774 bp from pter
Size:
14,180 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9 (See protein sequence)
Recommended Name: Nuclear RNA export factor 1  
Size: 619 amino acids; 70182 Da
Subunit: Heterodimer with NXT1. Interacts (via NTF2 domain) with NXT1. The formation of NXF1/NXT1 heterodimers is
required for the NXF1-mediated nuclear mRNA export. Interacts with NXT2, E1B-AP5, RAE1, ALYREF/THOC4 and with
several nucleoporins. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1,
NXF1, UPF1, UPF2, UPF3A, UPF3B, ALYREF/THOC4 and/or REFBP2. Found in a mRNA complex with RENT3A and RENT3B.
Interacts with FYTTD1/UIF, EIF4A3, NUPL2 and THOC5. Interacts with Saimiriine herpesvirus 2 TIP protein.
Interacts with human herpes virus 1 (HHV-1) ICP27 protein; this interaction allows efficient export of HHV-1
early and late transcripts
Subcellular location: Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Note=Localized predominantly in the
nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the
nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA
6/12 PDB 3D structures from and Proteopedia for NXF1 (see all 12):
1FO1 (3D)        1FT8 (3D)        1GO5 (3D)        1JKG (3D)        1JN5 (3D)        1KOH (3D)    
Secondary accessions: B4E269 Q99799 Q9UQL2
Alternative splicing: 2 isoforms:  Q9UBU9-1   Q9UBU9-2   

Explore the universe of human proteins at neXtProt for NXF1: NX_Q9UBU9

Explore proteomics data for NXF1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBU9

  • NXF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NXF1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001074960.1  NP_006353.2  

    ENSEMBL proteins: 
     ENSP00000453885   ENSP00000436679   ENSP00000434301   ENSP00000435742   ENSP00000431381  
     ENSP00000432530   ENSP00000437296   ENSP00000294172   ENSP00000408864  
    Reactome Protein details: Q9UBU9
    Human Recombinant Protein Products for NXF1: 
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    Cloud-Clone Corp. Proteins for NXF1 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005643nuclear pore IEA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----

    NXF1 for ontologies           About GeneDecksing



    NXF1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR002075 NTF2
     IPR015245 Tap_RNA-bd
     IPR005637 TAP_C_dom
     IPR001611 Leu-rich_rpt
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9UBU9

    ProtoNet protein and cluster: Q9UBU9

    4 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB002075 Nuclear transport factor 2 (NTF2)
    IPB003603 Leucine-rich-associated
    IPB005637 TAP C-terminal domain


    UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9
    Domain: The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats
    Domain: The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain
    (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in
    the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs
    Domain: The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from
    the nucleus
    Domain: The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient
    for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical
    role in the interaction with nucleoporins
    Domain: The leucine-rich repeats are essential for the export of mRNA from the nucleus
    Domain: The RNA-binding domain is a non-canonical RNP-type domain
    Similarity: Belongs to the NXF family
    Similarity: Contains 4 LRR (leucine-rich) repeats
    Similarity: Contains 1 NTF2 domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain
    Similarity: Contains 1 TAP-C domain


    NXF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NXF1_HUMAN, Q9UBU9
    Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE)
    and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export
    of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IEA--
    GO:0005487nucleocytoplasmic transporter activity IEA--
    GO:0005515protein binding IPI10924507
         
    NXF1 for ontologies           About GeneDecksing


    Phenotypes:
         14 GenomeRNAi human phenotypes for NXF1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased cell number, increas 
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A virus in  Decreased influenza A/WSN/33 r 
     Decreased viability  Decreased viability of wild-ty  G0/1 arrest  Increased gamma-H2AX phosphory 
     Increased number of mitotic ce  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nxf1):
     behavior/neurological  hearing/vestibular/ear  integument  mortality/aging  nervous system 
     pigmentation  renal/urinary system 

    NXF1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NXF1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NXF1 
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    SwitchGear 3'UTR luciferase reporter plasmidNXF1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NXF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NXF1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    2Transport of Mature mRNA Derived from an Intronless Transcript
    Transport of Mature mRNAs Derived from Intronless Transcripts0.89
    Transport of Mature mRNA Derived from an Intronless Transcript0.89
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.85
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    4Transport of the SLBP independent Mature mRNA
    Transport of the SLBP Dependant Mature mRNA0.83
    Transport of the SLBP independent Mature mRNA0.83
    5Influenza A
    Influenza A0.34
    Herpes simplex infection0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NXF1
        Translational Control

    1 BioSystems Pathway for NXF1
        mRNA processing

    5/9        Reactome Pathways for NXF1 (see all 9)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA Derived from an Intronless Transcript
    Transport of the SLBP independent Mature mRNA
    Transport of the SLBP Dependant Mature mRNA


    5         Kegg Pathways  (Kegg details for NXF1):
        Ribosome biogenesis in eukaryotes
    RNA transport
    mRNA surveillance pathway
    Influenza A
    Herpes simplex infection


    NXF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NXF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/124 Interacting proteins for NXF1 (Q9UBU91, 2, 3 ENSP000002941724) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRSF7Q166292, 3, ENSP000003259054MINT-3380010 MINT-3380040 MINT-3380069 I2D: score=4 STRING: ENSP00000325905
    RAE1P784062, 3, ENSP000003602864MINT-14382 MINT-14383 I2D: score=3 STRING: ENSP00000360286
    NUP98P529482, 3, ENSP000003160324MINT-15768 I2D: score=4 STRING: ENSP00000316032
    NUP214P356582, 3, ENSP000003524004MINT-15076 I2D: score=3 STRING: ENSP00000352400
    SRSF1Q079551, 3, ENSP000002589624EBI-398874,EBI-398920 I2D: score=3 STRING: ENSP00000258962
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006405RNA export from nucleus ----
    GO:0006406mRNA export from nucleus TAS--
    GO:0006810transport ----
    GO:0010467gene expression TAS--
    GO:0016973poly(A)+ mRNA export from nucleus IEA--

    NXF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NXF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NXF1

    3 Novoseek inferred chemical compound relationships for NXF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 12.6 6 20129943 (2), 17668007 (1), 11358864 (1)
    serine 7.58 1 15210956 (1)
    atp 0 3 9408957 (1), 12473688 (1)

    Search CenterWatch for drugs/clinical trials and news about NXF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NXF1 gene (2 alternative transcripts): 
    NM_001081491.1  NM_006362.4  

    Unigene Cluster for NXF1:

    Nuclear RNA export factor 1
    Hs.523739  [show with all ESTs]
    Unigene Representative Sequence: NM_001081491
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531709(uc001nvg.1 uc010rmh.1) ENST00000532297 ENST00000527902
    ENST00000533048 ENST00000533499 ENST00000527497 ENST00000530875(uc009yog.1)
    ENST00000533440 ENST00000531872 ENST00000531579 ENST00000526163 ENST00000531131
    ENST00000533671 ENST00000525576 ENST00000531474 ENST00000527064 ENST00000294172(uc001nvf.1)
    ENST00000439713
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB209915.1 AF112880.1 AF126246.1 AJ132712.1 AK027192.1 AK304082.1 AK304137.1 AK304743.1 
    AK307961.1 AK307998.1 BC004904.2 BC017421.1 BC028041.1 CR749674.1 U80073.1 Z36505.1 

    24/30 DOTS entries (see all 30):

    DT.100643758  DT.100648210  DT.99934843  DT.120700981  DT.101983229  DT.40269943  DT.40286116  DT.100648211 
    DT.120700997  DT.91741762  DT.120700962  DT.97795449  DT.100648213  DT.120700941  DT.120700951  DT.120701041 
    DT.121430873  DT.40132239  DT.91667990  DT.95092191  DT.95092203  DT.120700933  DT.120700998  DT.120701010 

    24/617 AceView cDNA sequences (see all 617):

    BP376199 BC028041 D83883 BM151310 AW293492 BM770264 AI937892 CB108243 
    AI268369 BI062710 T17340 AW665636 AI364308 BM771520 CA435376 BM770258 
    AI362833 AU137756 BU633875 BE891374 BU188904 BM766917 AI343383 AI051543 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for NXF1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^
    SP1:                    -                                                                 -                                         -     -     -               
    SP2:                                                                                                                                                            
    SP3:                    -     -     -     -     -     -     -                 -     -     -     -     -     -           -           -     -     -     -         
    SP4:                                                                                                                                                            
    SP5:                    -                       -                                                                                                               

    ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24
    SP1:                                            -                     
    SP2:                                            -                     
    SP3:        -                                                         
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for NXF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NXF1 expression in normal human tissues (normalized intensities)      NXF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCAGAAGC
    NXF1 Expression
    About this image


    NXF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See NXF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NXF1

    SOURCE GeneReport for Unigene cluster: Hs.523739

    UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9
    Tissue specificity: Expressed ubiquitously

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NXF1 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nxf11 , 5 nuclear RNA export factor 1 homolog (S. cerevisiae)5
    nuclear RNA export factor 11
    87.54(n)1
    91.26(a)1
      19 (5.50 cM)5
    533191  NM_016813.21  NP_058093.21 
     87571035 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    possible ortholog
    GL343739.1(136184-168794)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB591324.12   -- 73.19(n)    CB591324.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mgab03e052 mgab03e05 71.4(n)   326948  BG727737.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sbr1 , 3 poly(A)+ mRNA-nucleus export3
    small bristles1
    32(a)3
    45.22(n)1
    36(a)1
      439441  NM_079921.31  NP_524660.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nxf-13
    nxf-21
    Leucine Rich Repeat (2 copies)3
    Protein NXF-21
    27(a)3
    42.95(n)1
    32.29(a)1
      V(14415218-14418389)3
    1799381  NM_074167.51  NP_506568.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MEX67(YPL169C)4
    MEX671
    Poly(A)RNA binding protein involved in nuclear mRNA more4
    Mex67p1
    37.16(n)1
    27.46(a)1
      16(230838-229039)4
    8559341, 4  NP_015156.11, 4 


    ENSEMBL Gene Tree for NXF1 (if available)
    TreeFam Gene Tree for NXF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NXF1 gene
    NXF32  NXF2B2  NXF22  NXF52  
    5 SIMAP similar genes for NXF1 using alignment to 6 protein entries:     NXF1_HUMAN (see all proteins):
    DKFZp667O0311    NXF2B    NXF2    NXF5    NXF3

    NXF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/301 SNPs in NXF1 are shown (see all 301)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776187591,2
    --62561563(+) GTGCCC/TAGGAA 2 -- int10--------
    rs1381938071,2
    C,F--62561743(+) CCACTC/G/TGAGGT 5 K Q E ut31 mis11NA 4552
    rs1813253491,2
    C--62561744(+) CACTCA/GAGGTT 3 L ut31 syn10--------
    rs2012748331,2
    --62561931(+) AGCACG/TTAAAA 2 -- int10--------
    rs1839163431,2
    C--62561946(+) AGACAA/GAGATA 2 -- int10--------
    rs1890440571,2
    C--62562009(+) GGTCCC/TCCTCC 2 -- int10--------
    rs1412137291,2
    C--62562110(+) CCAACA/GCATGG 2 -- int10--------
    rs1820704581,2
    --62562133(+) TTAATG/TCATCC 2 -- int10--------
    rs786944901,2
    F--62562161(+) AATGAA/GTATTG 2 -- int11Minor allele frequency- G:0.01WA 118
    rs784336861,2
    F--62562236(+) CCAGAC/TGGTAC 2 -- int11Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for NXF1 (62559595 - 62573774 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NXF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509416CNV Insertion20534489
    nsv897624CNV Loss21882294
    nsv483055CNV Loss15286789
    nsv508636CNV Loss20534489
    nsv897623CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602647    OMIM disorders: --

    17 diseases for NXF1:    About MalaCards
    branchiootorenal syndrome    genital herpes    chickenpox    kaposi's sarcoma
    conjunctivitis    intellectual disability    graves' disease    herpes simplex
    hepatocellular carcinoma    influenza    sarcoma    hepatitis c
    mental retardation    melanoma    hepatitis    gastric cancer
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NXF1:
    Branchiootorenal syndrome

    NXF1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for NXF1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 7.77 4 19776134 (1), 8597949 (1), 11259602 (1), 10951562 (1)
    virus infection 0 1 15096184 (1)
    hepatocellular carcinoma 0 1 8803612 (1)
    tumors 0 2 8803612 (1), 17278102 (1)


    Export disorders for NXF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NXF1 gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with NXF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. (PubMed id 9660949)1, 2, 3, 9 Gruter P....Izaurralde E. (1998)
    2. Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. (PubMed id 9175835)1, 2, 3, 9 Yoon D.-W.... Jung J.U. (1997)
    3. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. (PubMed id 10202158)1, 2, 9 Braun I.C.... Izaurralde E. (1999)
    4. Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. (PubMed id 11259411)1, 2, 9 Braun I.C.... Izaurralde E. (2001)
    5. The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain. (PubMed id 11060011)1, 2, 9 Liker E.... Conti E. (2000)
    6. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. (PubMed id 10228171)1, 2, 9 Katahira J....Hurt E. (1999)
    7. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. (PubMed id 11583626)1, 2, 9 Fribourg S.... Conti E. (2001)
    8. Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. (PubMed id 19165146)1, 2, 9 Katahira J.... Yoneda Y. (2009)
    9. Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolution. (PubMed id 12581645)1, 2, 9 Grant R.P.... Stewart M. (2003)
    10. Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. (PubMed id 11707413)1, 2, 9 Kataoka N.... Dreyfuss G. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10482 HGNC: 8071 AceView: NXF1andMGC3196 Ensembl:ENSG00000162231 euGenes: HUgn10482
    ECgene: NXF1 Kegg: 10482 H-InvDB: NXF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NXF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NXF1 gene:
    Search GeneIP for patents involving NXF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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