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Aliases for NXF1 Gene

Aliases for NXF1 Gene

  • Nuclear RNA Export Factor 1 2 3 5
  • Tip Associating Protein 2 3
  • Tip-Associating Protein 3 4
  • Tip-Associated Protein 3 4
  • MRNA Export Factor TAP 3 4
  • TAP 3 4
  • MEX67 3

External Ids for NXF1 Gene

Previous GeneCards Identifiers for NXF1 Gene

  • GC11M065072
  • GC11M064135
  • GC11M062810
  • GC11M062335
  • GC11M062316
  • GC11M062559
  • GC11M058888

Summaries for NXF1 Gene

Entrez Gene Summary for NXF1 Gene

  • This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for NXF1 Gene

NXF1 (Nuclear RNA Export Factor 1) is a Protein Coding gene. Diseases associated with NXF1 include influenza. Among its related pathways are Gene Expression and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include poly(A) RNA binding and nucleotide binding. An important paralog of this gene is NXF2.

UniProtKB/Swiss-Prot for NXF1 Gene

  • Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.

Gene Wiki entry for NXF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NXF1 Gene

Genomics for NXF1 Gene

Regulatory Elements for NXF1 Gene

Promoters for NXF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NXF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NXF1 Gene

Chromosome:
11
Start:
62,792,123 bp from pter
End:
62,806,302 bp from pter
Size:
14,180 bases
Orientation:
Minus strand

Genomic View for NXF1 Gene

Genes around NXF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NXF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NXF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NXF1 Gene

Proteins for NXF1 Gene

  • Protein details for NXF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU9-NXF1_HUMAN
    Recommended name:
    Nuclear RNA export factor 1
    Protein Accession:
    Q9UBU9
    Secondary Accessions:
    • B4E269
    • Q99799
    • Q9UQL2

    Protein attributes for NXF1 Gene

    Size:
    619 amino acids
    Molecular mass:
    70182 Da
    Quaternary structure:
    • Heterodimer with NXT1. Interacts (via NTF2 domain) with NXT1. The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export. Interacts with NXT2, E1B-AP5, RAE1, ALYREF/THOC4, DDX39B, FYTTD1/UIF, EIF4A3, NUPL2 and with several nucleoporins. Interacts with THOC5 and CHTOP; in a mutually exclusive manner. Associates with the exon junction complex (EJC) and with the transcription/export (TREX) complex. Found in a mRNA complex with RENT3A and RENT3B. Interacts with Saimiriine herpesvirus 2 TIP protein. Interacts with human herpes virus 1 (HHV-1) ICP27 protein; this interaction allows efficient export of HHV-1 early and late transcripts. Interacts with FRG1 (via N-terminus). Interacts with LUZP4.

    Three dimensional structures from OCA and Proteopedia for NXF1 Gene

    Alternative splice isoforms for NXF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NXF1 Gene

Proteomics data for NXF1 Gene at MOPED

Post-translational modifications for NXF1 Gene

  • Ubiquitination at Lys 117, Lys 173, and Lys 230
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NXF1 (NXF1)

No data available for DME Specific Peptides for NXF1 Gene

Domains & Families for NXF1 Gene

Suggested Antigen Peptide Sequences for NXF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBU9

UniProtKB/Swiss-Prot:

NXF1_HUMAN :
  • The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats.
  • Belongs to the NXF family.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats.
  • The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs.
  • The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from the nucleus. It inhibits RNA binding activity through an intramolecular interaction with the N-terminal RNA binding domain (RBD); the inhibition is removed by an association with the TREX complex, specifically involving ALYREF/THOC4 and THOC5.
  • The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in the interaction with nucleoporins.
  • The leucine-rich repeats are essential for the export of mRNA from the nucleus.
  • The RNA-binding domain is a non-canonical RNP-type domain.
  • Contains 1 NTF2 domain.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 TAP-C domain.
Family:
  • Belongs to the NXF family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NXF1: view

No data available for Gene Families for NXF1 Gene

Function for NXF1 Gene

Molecular function for NXF1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.

Gene Ontology (GO) - Molecular Function for NXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005487 nucleocytoplasmic transporter activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NXF1: view
genes like me logo Genes that share phenotypes with NXF1: view

Animal Model Products

miRNA for NXF1 Gene

miRTarBase miRNAs that target NXF1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NXF1 Gene

Localization for NXF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NXF1 Gene

Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Nucleus. Note=Localized predominantly in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. The association with the TREX complex seems to occur in regions surrounding nuclear speckles known as perispeckles (PubMed:23826332). Nucleus; nuclear rim (PubMed:25662211). {ECO:0000269 PubMed:23826332, ECO:0000269 PubMed:25662211}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NXF1 Gene COMPARTMENTS Subcellular localization image for NXF1 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for NXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 25662211
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IDA 23826332
genes like me logo Genes that share ontologies with NXF1: view

Pathways & Interactions for NXF1 Gene

genes like me logo Genes that share pathways with NXF1: view

SIGNOR curated interactions for NXF1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0016032 viral process IEA --
GO:0051028 mRNA transport IEA --
genes like me logo Genes that share ontologies with NXF1: view

Drugs & Compounds for NXF1 Gene

(3) Drugs for NXF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NXF1: view

Transcripts for NXF1 Gene

Unigene Clusters for NXF1 Gene

Nuclear RNA export factor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NXF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - - - - -
SP2:
SP3: - - - - - - - - - - - - - - - - - -
SP4:
SP5: - -
SP6:
SP7: - - -
SP8: - - - -
SP9:
SP10: - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12:

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for NXF1 Gene

GeneLoc Exon Structure for
NXF1
ECgene alternative splicing isoforms for
NXF1

Expression for NXF1 Gene

mRNA expression in normal human tissues for NXF1 Gene

Protein differential expression in normal tissues from HIPED for NXF1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.9) and Testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NXF1 Gene



SOURCE GeneReport for Unigene cluster for NXF1 Gene Hs.523739

mRNA Expression by UniProt/SwissProt for NXF1 Gene

Q9UBU9-NXF1_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expression patterns with NXF1: view

Protein tissue co-expression partners for NXF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NXF1 Gene

Orthologs for NXF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NXF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NXF1 36
  • 100 (a)
OneToOne
NXF1 35
  • 99.73 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia NXF1 35
  • 88.3 (n)
  • 93.2 (a)
NXF1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NXF1 36
  • 93 (a)
OneToOne
NXF1 35
  • 90.08 (n)
  • 94.66 (a)
mouse
(Mus musculus)
Mammalia Nxf1 16
Nxf1 36
  • 91 (a)
OneToOne
Nxf1 35
  • 87.54 (n)
  • 91.26 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NXF1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nxf1 35
  • 88.13 (n)
  • 92.07 (a)
lizard
(Anolis carolinensis)
Reptilia NXF1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nxf1 35
  • 63.96 (n)
  • 62.76 (a)
Str.6094 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2787 35
zebrafish
(Danio rerio)
Actinopterygii mgab03e05 35
nxf1 35
  • 62.47 (n)
  • 64.05 (a)
nxf1 36
  • 61 (a)
OneToMany
NXF1 (2 of 4) 36
  • 49 (a)
OneToMany
NXF1 (3 of 4) 36
  • 49 (a)
OneToMany
NXF1 (4 of 4) 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002193 35
  • 48.98 (n)
  • 41.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta sbr 37
  • 32 (a)
nxf2 36
  • 16 (a)
ManyToMany
Nxf3 36
  • 21 (a)
ManyToMany
sbr 36
  • 29 (a)
ManyToMany
sbr 35
  • 45.78 (n)
  • 37.35 (a)
worm
(Caenorhabditis elegans)
Secernentea nxf-1 37
  • 27 (a)
nxf-1 36
  • 25 (a)
ManyToMany
nxf-2 36
  • 26 (a)
ManyToMany
nxf-2 35
  • 43.18 (n)
  • 32.16 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL104C 35
  • 41.12 (n)
  • 29.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MEX67 35
  • 37.68 (n)
  • 29.44 (a)
MEX67 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09801g 35
  • 38.55 (n)
  • 28.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mex67 35
  • 42.42 (n)
  • 31.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for NXF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NXF1 Gene

ENSEMBL:
Gene Tree for NXF1 (if available)
TreeFam:
Gene Tree for NXF1 (if available)

Paralogs for NXF1 Gene

Paralogs for NXF1 Gene

(5) SIMAP similar genes for NXF1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NXF1: view

Variants for NXF1 Gene

Sequence variations from dbSNP and Humsavar for NXF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs4693 -- 62,796,537(-) GACCG(A/G)CAAGG reference, synonymous-codon, utr-variant-3-prime
rs489275 -- 62,799,911(+) CTTGG(C/T)GCAAG intron-variant, utr-variant-3-prime
rs2298634 -- 62,795,869(+) GACCA(C/T)GCTAC intron-variant
rs2850598 -- 62,798,240(-) atgtt(C/G)gccag intron-variant
rs3763851 -- 62,804,961(+) CAAGA(A/C)CGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NXF1 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
nsv897624 CNV Loss 21882294

Variation tolerance for NXF1 Gene

Residual Variation Intolerance Score: 5.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NXF1 Gene

HapMap Linkage Disequilibrium report
NXF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NXF1 Gene

Disorders for NXF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NXF1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
- elite association - COSMIC cancer census association via MalaCards
Search NXF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NXF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NXF1
genes like me logo Genes that share disorders with NXF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NXF1 Gene

Publications for NXF1 Gene

  1. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. (PMID: 9660949) Grueter P. … Izaurralde E. (Mol. Cell 1998) 2 3 4 23 67
  2. Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. (PMID: 9175835) Yoon D.-W. … Jung J.U. (Immunity 1997) 2 3 23
  3. TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation. (PMID: 20123736) Lee K.M. … Tarn W.Y. (Nucleic Acids Res. 2010) 3 23
  4. Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. (PMID: 19165146) Katahira J. … Yoneda Y. (EMBO J. 2009) 3 23
  5. Formation of a Tap/NXF1 homotypic complex is mediated through the amino-terminal domain of Tap and enhances interaction with nucleoporins. (PMID: 17978099) Matzat L.H. … LAcvesque L. (Mol. Biol. Cell 2008) 3 23

Products for NXF1 Gene

Sources for NXF1 Gene

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