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NXF1 Gene

protein-coding GIFtS: 57

GC11M062316

nuclear RNA export factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp667O0311 ^¹, ²
MEX67 ^², ⁵
Mex67 ^¹
TAP ^¹, ², ³, ⁵

Descriptions
Tip-associated protein ^³
Tip-associating protein ^³
mRNA export factor TAP ^³
nuclear RNA export factor 1 ^²
tip associating protein ^²

External Ids
HGNC: 8071¹
Entrez Gene: 10482²
UniProtKB: Q9UBU9³
Ensembl: ENSG00000162231⁷

Search outside databases for aliases for NXF1 gene

Previous GC identifers: GC11M065072 GC11M064135 GC11M062810 GC11M062335

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NXF1:

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of

this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a

nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related

export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with

nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative

splicing seems to be a common mechanism in this gene family. The encoded protein of this gene

shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the

vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export

block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of

type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by

RefSeq]

UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9

Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport

elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm

Gene Wiki entry for NXF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NXF1 gene

Entrez Gene cytogenetic band: 11q12-q13 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12-q13

NXF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M062316: (about GC identifiers)

Start:	62,316,174 bp from pter
End:	62,329,540 bp from pter
Size:	13,367 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9 (See protein sequence)

Recommended Name: Nuclear RNA export factor 1

Size: 619 amino acids; 70182 Da

Subunit: Interacts with NXT1, NXT2, E1B-AP5, RAE1, THOC4 and with several nucleoporins. Is part of

the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, RENT1, RENT2,

RENT3A, RENT3B and THOC4. Found in a mRNA complex with RENT3A and RENT3B. Interacts with

Saimiriine herpesvirus 2 TIP protein. Interacts with NUPL2

Subcellular location: Nucleus, nucleoplasm. Cytoplasm. Note=Localized predominantly in the

nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex.

Shuttles between the nucleus and the cytoplasm

Miscellaneous: The RNA-binding domain is a non-canonical RNP-type domain

PDB structures from and Proteopedia :

1FO1 (3D)

1FT8 (3D)

1GO5 (3D)

1JKG (3D)

1JN5 (3D)

1KOH (3D)

1KOO (3D)

1OAI (3D)

2Z5K (3D)

2Z5M (3D)

Secondary accessions: Q99799 Q9UQL2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001074960.1 NP_006353.2

ENSEMBL proteins:

ENSP00000294172

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NXF1)
	Human Recombinant Proteins from Abnova (NXF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005643	nuclear pore	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0042405	nuclear inclusion body	IEA	--

About this table

Antibodies for NXF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for NXF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NXF1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for NXF1

Assays for NXF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UBU9

ProtoNet protein and cluster: Q9UBU9

4 Blocks protein families:

IPB001611 Leucine-rich repeat signature

IPB002075 Nuclear transport factor 2 (NTF2)

IPB003603 Leucine-rich-associated

IPB005637 TAP C-terminal domain

UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9

Domain: The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and

leucine-rich repeats

Domain: The nucleoporin binding domain consists of a NTF2-like domain and a TAP domain (also called

UBA-like domain). The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1

heterodimers is required for NXF1-mediated nuclear mRNA export. The TAP domain mediates direct

interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1

to the nuclear rim. The conserved loop 594-NWD-596 of the UBA domain has a critical role in the

interaction with nucleoporins

Domain: The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the

nucleus

Similarity: Belongs to the NXF family

Similarity: Contains 4 LRR (leucine-rich) repeats

Similarity: Contains 1 NTF2 domain

Similarity: Contains 1 RRM (RNA recognition motif) domain

Similarity: Contains 1 TAP-C domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NXF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NXF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006362

Applied Biosystems Silencer® siRNAs for NXF1

Sigma-Aldrich siRNA for NXF1

Sigma-Aldrich shRNA for NXF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NXF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001081491
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001081491
untagged cDNA clones in CMV expression vector (see all 2): NM_001081491

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006362

UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9

Function: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport

elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nxf1):

behavior/neurological	hearing/vestibular/ear	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system
renal/urinary system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003729	mRNA binding	IEA	--
GO:0005487	nucleocytoplasmic transporter activity	IEA	--
GO:0005515	protein binding	IPI	9175835 10924507 11583626 15184380

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for NXF1

5/62 Interacting proteins for NXF1 (ENSP00000294172³ Q9UBU9^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 62 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFRS3	P84103²	STRING (score=.978) MINT-3379978 MINT-3380604 MINT-3379948 MINT-3380578
RAE1	P78406²	STRING (score=.997) MINT-14382 MINT-14383
TNPO1	Q92973²	STRING (score=.805) MINT-15485 MINT-15486
NUP214	P35658²	STRING (score=.987) MINT-15076
NUP98	P52948²	STRING (score=.996) MINT-15768

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006405	RNA export from nucleus	IEA	--
GO:0006810	transport	IEA	--
GO:0016973	poly(A)+ mRNA export from nucleus	IEA	--
GO:0044419	interspecies interaction between organisms	IEA	--
GO:0051028	mRNA transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NXF1
1 Novoseek chemical compound relationship for NXF1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	0.00	3	9408957 (1), 12473688 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NXF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NXF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006362

Sigma-Aldrich siRNA for NXF1

Sigma-Aldrich shRNA for NXF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001081491 NM_006362

REFSEQ mRNAs for NXF1 gene (2 alternative transcripts):

NM_001081491.1 NM_006362.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001081491 NM_006362

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001081491
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001081491
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001081491

Additional cDNA sequence:

AB209915.1 AF112880.1 AF126246.1 AJ132712.1 AK027192.1 AK304082.1 AK304137.1 AK304743.1

AK307961.1 AK307998.1 BC004904.2 BC017421.1 BC028041.1 CR594029.1 CR597811.1 CR749674.1

U80073.1 Z36505.1

24/30 DOTS entries (see all 30 ):

DT.100643758 DT.100648210 DT.99934843 DT.120700981 DT.101983229 DT.40286116 DT.40269943 DT.100648211

DT.120700997 DT.91741762 DT.120700962 DT.97795449 DT.100648213 DT.120700941 DT.120700951 DT.120701041

DT.121430873 DT.40132239 DT.91667990 DT.95092191 DT.95092203 DT.120700933 DT.120700956 DT.120700998

24/617 AceView cDNA sequences (see all 617 ):

CB159023 AI922299 AA479748 BI962699 BU188904 BM842108 AI369653 BM975068

BP376199 BM996698 BQ072861 AI879044 BQ956729 BM756732 BI761681 BU077643

BM977521 AA346429 BU740212 BM835529 BM997736 AI910623 BM766761 AW293492

highest scoring ESTs for NXF1:

AW812073 AL602107 AL703317 AL709153 AU098854 AU129872 AU137484 AU137756 BE891374 BG897456

Unigene Cluster for NXF1:

Nuclear RNA export factor 1

Hs.523739 [show with all ESTs]

Unigene Representative Sequence: NM_001081491

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for NXF1 (see all 12 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^
SP1:							-																						-														-		-		-
SP2:
SP3:							-		-		-		-		-		-		-						-		-		-		-		-		-				-				-		-		-		-
SP4:
SP5:							-								-

ExUns:	16	^	17	^	18a	·	18b	^	19	^	20	^	21a	·	21b	^	22	^	23	^	24
SP1:															-
SP2:															-
SP3:			-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for NXF1

1 Ensembl transcript including schematic representation:

ENST00000294172

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NXF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NXF1

¹ / ² / ³

3 probe-sets matching NXF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35302_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	AJ132712	0.60	0.50	0.55	1
208922_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	BC004904	0.40	0.38	0.39	1
208922_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.523739
Expression variation in blood from EXPOLDB for NXF1
UniProtKB/Swiss-Prot: NXF1_HUMAN, Q9UBU9
Tissue specificity: Expressed ubiquitously

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NXF1 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NXF1¹	--	nuclear RNA export factor 1	88.51(n) 92.49(a)	483780 XM_540901.2 XP_540901.2
chimpanzee (Pan troglodytes)	NXF1¹	--	nuclear RNA export factor 1	99.73(n) 100(a)	451267 XM_001157986.1 XP_001157986.1
cow (Bos taurus)	NXF1¹	--	nuclear RNA export factor 1	88.3(n) 93.2(a)	512136 NM_001075555.1 NP_001069023.1
rat (Rattus norvegicus)	Nxf1¹	--	nuclear RNA export factor 1	88.13(n) 92.07(a)	59087 NM_021579.1 NP_067590.1
mouse (Mus musculus)	Nxf1^{1, 5}	19 (5.00 cM)⁵	nuclear RNA export factor 1 homolog (S. cerevisiae)^{1, 5}	87.54(n)¹ 91.26(a)¹	53319¹ NM_016813.2¹ NP_058093.2¹ AF093140⁵ AI452172⁵ (see all 17)

About this table Species with no ortholog for NXF1

ENSEMBL Gene Tree for NXF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NXF1 gene

NXF3² NXF4² NXF2B² NXF2² NXF5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/34 NCBI SNPs in NXF1 are shown (see all 34 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 33)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4693^1,2	A,C,F,H	62320585(-)	`GACCGG/ACAAGG`	2	R/R	syn¹ ut3¹ ese³		7		MN EU EA WA	2286
	rs631310^1,2	A,C,F,H	62324212(+)	`GCAAAC/TAGATA`	2	--	int¹ ut3¹		10		MN EA EU WA	2518
--	rs529220^1,2	A,C,F	62330057(-)	`AAATAC/TATGTT`	2	--	ng3¹		1		MN	184
	rs3881262^1,2	H	62323984(-)	`TTGTAC/TTGTGA`	2	--	int¹ ut3¹		4		EU EA WA	414
	rs3763851^1,2	A,C,F,H	62329009(+)	`CAAGAC/ACGACT`	2	--	int¹		9		EA EU WA	2138
--	rs7105855^1,2	A,C	62320989(+)	`acacaC/Tctgta`	2	--	int¹		0	--	--	--	--
	rs490791^1,2	C	62327721(+)	`TAATCA/CCTAAG`	2	--	int¹		1		MN	184
	rs539465^1,2	C	62319929(-)	`AGTCCT/CGAGTT`	2	--	int¹		1		MN	184
--	rs561520^1,2	F	62327196(+)	`accccG/Atctct`	2	--	int¹		2		NA	30
	rs2298634^1,2	H	62319917(+)	`GACCAC/TGCTAC`	2	--	int¹		5		EA EU WA	1920

About this table

HapMap Linkage Disequilibrium images for NXF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602647

4 Novoseek disease relationships for NXF1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	1.57	3	8597949 (1), 11259602 (1), 10951562 (1)
tumors	0.00	2	8803612 (1), 17278102 (1)
hepatocellular carcinoma	0.00	1	8803612 (1)
virus infection	0.00	1	15096184 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/99 PubMed articles for NXF1 gene (see all 99 ):

TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. (PubMed id 9660949)^{1, 2, 3, 4} Gruter P....Izaurralde E. (1998)
Tap: a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. (PubMed id 9175835)^{1, 2, 3, 4} Yoon D.-W.... Jung J.U. (1997)
TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus. (PubMed id 10202158)^{1, 3, 4} Braun I.C.... Izaurralde E. (1999)
Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. (PubMed id 11259411)^{1, 3, 4} Braun I.C.... Izaurralde E. (2001)
The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain. (PubMed id 11060011)^{1, 3, 4} Liker E.... Conti E. (2000)
The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. (PubMed id 10228171)^{1, 3, 4} Katahira J....Hurt E. (1999)
Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. (PubMed id 11583626)^{1, 3, 4} Fribourg S.... Conti E. (2001)
Structural basis for the interaction between the Tap/NXF1 UBA domain and FG nucleoporins at 1A resolution. (PubMed id 12581645)^{1, 3, 4} Grant R.P.... Stewart M. (2003)
Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex. (PubMed id 11707413)^{1, 3, 4} Kataoka N.... Dreyfuss G. (2001)
Role of the nonsense-mediated decay factor hUpf3 in the splicing- dependent exon-exon junction complex. (PubMed id 11546873)^{1, 3, 4} Kim V.N.... Dreyfuss G. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10482	HGNC: 8071	AceView: NXF1andMGC3196	Ensembl:ENSG00000162231	euGenes: HUgn10482
ECgene: NXF1	H-InvDB: NXF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NXF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NXF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NXF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NXF1		Antibodies for NXF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NXF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NXF1)
	Search for Antibodies
	Chimera RNAi (NXF1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (NXF1)
	Antibodies (NXF1)

Search OriGene for NXF1

Search Tocris compounds for NXF1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for NXF1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
NXF1 Gene at Home site.
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NXF1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for NXF1

Summaries
for NXF1

Genomic Location
for NXF1

Proteins
for NXF1

Protein Domains/
Families
for NXF1

Gene Function
for NXF1

Pathways & Interactions
for NXF1

Drugs & Compounds
for NXF1

Transcripts
for NXF1

Expression
for NXF1

Orthologs
for NXF1

Paralogs
for NXF1

SNPs/Variants
for NXF1

Disorders & Mutations
for NXF1

Medical News
for NXF1

Publications
for NXF1

Search for NXF1

Genome Databases showing NXF1

Other Databases showing NXF1

Specialized Databases showing NXF1

Licensable Technologies
for NXF1

Services
for NXF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NXF1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor NXF1

Summariesfor NXF1

Genomic Locationfor NXF1

Proteinsfor NXF1

Protein Domains/Familiesfor NXF1

Gene Functionfor NXF1

Pathways & Interactionsfor NXF1

Drugs & Compoundsfor NXF1

Transcriptsfor NXF1

Expression for NXF1

Orthologsfor NXF1

Paralogsfor NXF1

SNPs/Variantsfor NXF1

Disorders & Mutationsfor NXF1

Medical Newsfor NXF1

Publicationsfor NXF1

Search for NXF1

Genome Databases showing NXF1

Other Databases showing NXF1

Specialized Databases showing NXF1

Licensable Technologiesfor NXF1

Servicesfor NXF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NXF1

Summaries
for NXF1

Genomic Location
for NXF1

Proteins
for NXF1

Protein Domains/
Families
for NXF1

Gene Function
for NXF1

Pathways & Interactions
for NXF1

Drugs & Compounds
for NXF1

Transcripts
for NXF1

Expression
for NXF1

Orthologs
for NXF1

Paralogs
for NXF1

SNPs/Variants
for NXF1

Disorders & Mutations
for NXF1

Medical News
for NXF1

Publications
for NXF1

Licensable Technologies
for NXF1

Services
for NXF1