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Aliases for NWD2 Gene

Aliases for NWD2 Gene

  • NACHT And WD Repeat Domain Containing 2 2 3 5
  • KIAA1239 2 3 4
  • Leucine-Rich Repeat And WD Repeat-Containing Protein KIAA1239 4
  • NACHT And WD Repeat Domain-Containing Protein 2 3

External Ids for NWD2 Gene

Previous HGNC Symbols for NWD2 Gene

  • KIAA1239

Summaries for NWD2 Gene

GeneCards Summary for NWD2 Gene

NWD2 (NACHT And WD Repeat Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is NWD1.

Additional gene information for NWD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NWD2 Gene

Genomics for NWD2 Gene

GeneHancer (GH) Regulatory Elements for NWD2 Gene

Promoters and enhancers for NWD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I037244 Promoter 0.8 EPDnew 550.8 -0.1 -55 0.1 CTCF MXI1 L3MBTL2 CTBP2 EZH2 NWD2 MIR4801
GH04I037390 Enhancer 0.6 Ensembl 10.3 +145.9 145881 0.2 SMARCA5 CTCF ZNF654 TRIM22 REST PAX8 RAD21 NBN SMC3 ZNF143 NWD2 C4orf19
GH04I037366 Enhancer 0.6 FANTOM5 10 +121.9 121905 0.2 TEAD4 JUN CBFA2T3 DPF2 EP300 TCF12 FOSL1 NCOR1 SMARCA4 IKZF1 NWD2 C4orf19
GH04I037429 Enhancer 1.1 ENCODE dbSUPER 0.1 +186.6 186580 3.1 ELF3 FOXA2 ARID4B FEZF1 RARA YY1 SCRT2 ATF7 IKZF2 THAP11 C4orf19 NWD2
GH04I037438 Enhancer 1 ENCODE dbSUPER 0.1 +196.9 196878 5.6 PKNOX1 CLOCK FOXA2 NEUROD1 RARA ZNF366 SCRT2 ATF7 FOS SP3 ENSG00000248936 C4orf19 PGM2 NWD2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NWD2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NWD2 Gene

Genomic Locations for NWD2 Gene
chr4:37,244,220-37,449,465
(GRCh38/hg38)
Size:
205,246 bases
Orientation:
Plus strand
chr4:37,245,842-37,451,087
(GRCh37/hg19)

Genomic View for NWD2 Gene

Genes around NWD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NWD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NWD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NWD2 Gene

Proteins for NWD2 Gene

  • Protein details for NWD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULI1-NWD2_HUMAN
    Recommended name:
    NACHT and WD repeat domain-containing protein 2
    Protein Accession:
    Q9ULI1
    Secondary Accessions:
    • A8MRU1

    Protein attributes for NWD2 Gene

    Size:
    1742 amino acids
    Molecular mass:
    197466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NWD2 Gene

Post-translational modifications for NWD2 Gene

No Post-translational modifications

Other Protein References for NWD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NWD2 Gene

Domains & Families for NWD2 Gene

Gene Families for NWD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NWD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NWD2: view

No data available for UniProtKB/Swiss-Prot for NWD2 Gene

Function for NWD2 Gene

Phenotypes From GWAS Catalog for NWD2 Gene

Phenotypes for NWD2 Gene

genes like me logo Genes that share phenotypes with NWD2: view

Animal Model Products

CRISPR Products

miRNA for NWD2 Gene

miRTarBase miRNAs that target NWD2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NWD2 Gene

Localization for NWD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NWD2 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NWD2 Gene

Pathways & Interactions for NWD2 Gene

No Data Available

Interacting Proteins for NWD2 Gene

Gene Ontology (GO) - Biological Process for NWD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NWD2 Gene

Drugs & Compounds for NWD2 Gene

No Compound Related Data Available

Transcripts for NWD2 Gene

mRNA/cDNA for NWD2 Gene

(1) REFSEQ mRNAs :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NWD2 Gene

No ASD Table

Relevant External Links for NWD2 Gene

GeneLoc Exon Structure for
NWD2
ECgene alternative splicing isoforms for
NWD2

Expression for NWD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NWD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NWD2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.3), Brain - Frontal Cortex (BA9) (x8.0), Brain - Anterior cingulate cortex (BA24) (x7.5), Brain - Cortex (x6.9), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for NWD2 Gene

This gene is overexpressed in Ovary (30.2), Heart (29.3), and Fetal heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NWD2 Gene



Protein tissue co-expression partners for NWD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NWD2 Gene:

NWD2
genes like me logo Genes that share expression patterns with NWD2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NWD2 Gene

Orthologs for NWD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NWD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1239 33 34
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1239 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1239 33 34
  • 90.05 (n)
dog
(Canis familiaris)
Mammalia KIAA1239 33 34
  • 90.05 (n)
mouse
(Mus musculus)
Mammalia 3110047P20Rik 33 34
  • 88.17 (n)
Nwd2 16
rat
(Rattus norvegicus)
Mammalia RGD1563065 33
  • 88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1239 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1239 33 34
  • 77.27 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1239 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1239 33
  • 73.16 (n)
Str.9989 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.26394 33
zebrafish
(Danio rerio)
Actinopterygii AL935029.1 34
  • 72 (a)
OneToOne
LOC562320 33
  • 69.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10185 33 34
  • 44.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011163 33
  • 42.15 (n)
worm
(Caenorhabditis elegans)
Secernentea T05C3.2 34
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
ManyToMany
Species where no ortholog for NWD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NWD2 Gene

ENSEMBL:
Gene Tree for NWD2 (if available)
TreeFam:
Gene Tree for NWD2 (if available)

Paralogs for NWD2 Gene

Paralogs for NWD2 Gene

genes like me logo Genes that share paralogs with NWD2: view

Variants for NWD2 Gene

Sequence variations from dbSNP and Humsavar for NWD2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000003249 -- 37,432,176(+) T/C intron_variant
rs1000029480 -- 37,447,358(+) T/C 3_prime_UTR_variant
rs1000046728 -- 37,353,663(+) G/A intron_variant
rs1000052435 -- 37,314,462(+) T/G intron_variant
rs1000099230 -- 37,440,260(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NWD2 Gene

Variant ID Type Subtype PubMed ID
dgv1473e212 CNV loss 25503493
dgv2960e59 CNV duplication 20981092
dgv824e201 CNV deletion 23290073
dgv825e201 CNV deletion 23290073
esv1660515 CNV deletion 17803354
esv2445355 CNV deletion 19546169
esv26310 CNV gain 19812545
esv2727416 CNV deletion 23290073
esv2727417 CNV deletion 23290073
esv2727423 CNV deletion 23290073
esv2727426 CNV deletion 23290073
esv2727427 CNV deletion 23290073
esv2727428 CNV deletion 23290073
esv2763351 CNV loss 21179565
esv3303723 CNV mobile element insertion 20981092
esv3436556 CNV insertion 20981092
esv3569378 CNV loss 25503493
nsv4302 CNV insertion 18451855
nsv471989 CNV novel sequence insertion 20440878
nsv477990 CNV novel sequence insertion 20440878
nsv516377 CNV loss 19592680
nsv528187 CNV loss 19592680

Variation tolerance for NWD2 Gene

Gene Damage Index Score: 7.71; 83.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NWD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NWD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NWD2 Gene

Disorders for NWD2 Gene

Additional Disease Information for NWD2

No disorders were found for NWD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NWD2 Gene

Publications for NWD2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 4 58
  5. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3 58

Products for NWD2 Gene

Sources for NWD2 Gene

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