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Aliases for NWD2 Gene

Aliases for NWD2 Gene

  • NACHT And WD Repeat Domain Containing 2 2 3 5
  • KIAA1239 2 3 4
  • Leucine-Rich Repeat And WD Repeat-Containing Protein KIAA1239 4

External Ids for NWD2 Gene

Previous HGNC Symbols for NWD2 Gene

  • KIAA1239

Summaries for NWD2 Gene

GeneCards Summary for NWD2 Gene

NWD2 (NACHT And WD Repeat Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is NWD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NWD2 Gene

Genomics for NWD2 Gene

Genomic Location for NWD2 Gene

Chromosome:
4
Start:
37,244,220 bp from pter
End:
37,449,465 bp from pter
Size:
205,246 bases
Orientation:
Plus strand

Genomic View for NWD2 Gene

Genes around NWD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NWD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NWD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NWD2 Gene

No data available for Regulatory Elements for NWD2 Gene

Proteins for NWD2 Gene

  • Protein details for NWD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULI1-NWD2_HUMAN
    Recommended name:
    NACHT and WD repeat domain-containing protein 2
    Protein Accession:
    Q9ULI1
    Secondary Accessions:
    • A8MRU1

    Protein attributes for NWD2 Gene

    Size:
    1742 amino acids
    Molecular mass:
    197466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NWD2 Gene

Proteomics data for NWD2 Gene at MOPED

Post-translational modifications for NWD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NWD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NWD2 Gene

Domains & Families for NWD2 Gene

Suggested Antigen Peptide Sequences for NWD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULI1

UniProtKB/Swiss-Prot:

NWD2_HUMAN :
  • Contains 1 NACHT domain.
  • Contains 5 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 NACHT domain.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
  • Contains 11 WD repeats.
genes like me logo Genes that share domains with NWD2: view

No data available for Gene Families for NWD2 Gene

Function for NWD2 Gene

Phenotypes for NWD2 Gene

genes like me logo Genes that share phenotypes with NWD2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NWD2 Gene

Localization for NWD2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NWD2 Gene

Pathways & Interactions for NWD2 Gene

SuperPathways for NWD2 Gene

No Data Available

Interacting Proteins for NWD2 Gene

Gene Ontology (GO) - Biological Process for NWD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NWD2 Gene

Drugs & Compounds for NWD2 Gene

No Compound Related Data Available

Transcripts for NWD2 Gene

mRNA/cDNA for NWD2 Gene

(1) REFSEQ mRNAs :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NWD2 Gene

No ASD Table

Relevant External Links for NWD2 Gene

GeneLoc Exon Structure for
NWD2
ECgene alternative splicing isoforms for
NWD2

Expression for NWD2 Gene

mRNA expression in normal human tissues for NWD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NWD2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.3), Brain - Frontal Cortex (BA9) (x8.0), Brain - Anterior cingulate cortex (BA24) (x7.5), Brain - Cortex (x6.9), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for NWD2 Gene

This gene is overexpressed in Ovary (30.2), Heart (29.3), and Fetal heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NWD2 Gene



genes like me logo Genes that share expression patterns with NWD2: view

Protein tissue co-expression partners for NWD2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NWD2 Gene

Orthologs for NWD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NWD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1239 36
  • 100 (a)
OneToOne
KIAA1239 35
  • 99.62 (n)
  • 99.66 (a)
cow
(Bos Taurus)
Mammalia KIAA1239 35
  • 90.05 (n)
  • 96.15 (a)
KIAA1239 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1239 36
  • 96 (a)
OneToOne
KIAA1239 35
  • 90.05 (n)
  • 95.92 (a)
mouse
(Mus musculus)
Mammalia 3110047P20Rik 36
  • 95 (a)
OneToOne
Nwd2 16
3110047P20Rik 35
  • 88.17 (n)
  • 94.78 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA1239 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1239 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563065 35
  • 88 (n)
  • 94.19 (a)
chicken
(Gallus gallus)
Aves KIAA1239 35
  • 77.27 (n)
  • 83.76 (a)
KIAA1239 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1239 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26394 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1239 35
  • 73.16 (n)
  • 77.93 (a)
Str.9989 35
zebrafish
(Danio rerio)
Actinopterygii AL935029.1 36
  • 72 (a)
OneToOne
LOC562320 35
  • 69.34 (n)
  • 73.18 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011163 35
  • 42.15 (n)
  • 28.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10185 36
  • 23 (a)
OneToMany
CG10185 35
  • 44.72 (n)
  • 31.28 (a)
worm
(Caenorhabditis elegans)
Secernentea T05C3.2 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
ManyToMany
Species with no ortholog for NWD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NWD2 Gene

ENSEMBL:
Gene Tree for NWD2 (if available)
TreeFam:
Gene Tree for NWD2 (if available)

Paralogs for NWD2 Gene

Paralogs for NWD2 Gene

genes like me logo Genes that share paralogs with NWD2: view

Variants for NWD2 Gene

Sequence variations from dbSNP and Humsavar for NWD2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4634233 - 37,443,693(+) TCGAG(A/C)TGATT reference, missense
rs930303 -- 37,254,155(-) AACAT(A/G)TGTCA intron-variant
rs720438 -- 37,406,195(-) TATCA(C/T)TTACT intron-variant
rs1002362 -- 37,355,909(+) TTTTT(C/T)TTTTA intron-variant
rs1002363 -- 37,355,937(+) ACTTG(A/G)AATCA intron-variant

Variation tolerance for NWD2 Gene

Gene Damage Index Score: 7.71; 83.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NWD2 Gene

HapMap Linkage Disequilibrium report
NWD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NWD2 Gene

Disorders for NWD2 Gene

Relevant External Links for NWD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NWD2

No disorders were found for NWD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NWD2 Gene

Publications for NWD2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3

Products for NWD2 Gene

Sources for NWD2 Gene

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