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Aliases for NWD2 Gene

Aliases for NWD2 Gene

  • NACHT And WD Repeat Domain Containing 2 2 3 5
  • KIAA1239 2 3 4
  • Leucine-Rich Repeat And WD Repeat-Containing Protein KIAA1239 4
  • NACHT And WD Repeat Domain-Containing Protein 2 3

External Ids for NWD2 Gene

Previous HGNC Symbols for NWD2 Gene

  • KIAA1239

Summaries for NWD2 Gene

GeneCards Summary for NWD2 Gene

NWD2 (NACHT And WD Repeat Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is NWD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NWD2 Gene

Genomics for NWD2 Gene

Regulatory Elements for NWD2 Gene

Enhancers for NWD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F037389 0.5 Ensembl 10.3 +145.1 145082 0.6 MAX MYC NWD2 C4orf19
GH04F037390 0.6 Ensembl 10.3 +145.8 145841 0.5 CTCF ZNF654 TRIM22 REST RAD21 SMC3 NBN KDM1A NWD2 C4orf19
GH04F037366 0.3 FANTOM5 10 +121.9 121905 0.2 TAL1 JUN ARID1B JUND ZNF589 ATF3 SMARCA4 NCOR1 IKZF1 HMBOX1 NWD2 C4orf19
GH04F037408 0.5 ENCODE 0.1 +164.2 164200 0.7 ZFHX2 FOXA3 NR2F6 YY1 ENSG00000248936 C4orf19 NWD2
GH04F037421 0.2 ENCODE 0.1 +177.7 177717 0.3 HNF4G YY1 C4orf19 NWD2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NWD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NWD2 Gene

Chromosome:
4
Start:
37,244,220 bp from pter
End:
37,449,465 bp from pter
Size:
205,246 bases
Orientation:
Plus strand

Genomic View for NWD2 Gene

Genes around NWD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NWD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NWD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NWD2 Gene

Proteins for NWD2 Gene

  • Protein details for NWD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULI1-NWD2_HUMAN
    Recommended name:
    NACHT and WD repeat domain-containing protein 2
    Protein Accession:
    Q9ULI1
    Secondary Accessions:
    • A8MRU1

    Protein attributes for NWD2 Gene

    Size:
    1742 amino acids
    Molecular mass:
    197466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NWD2 Gene

Post-translational modifications for NWD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NWD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NWD2 Gene

Domains & Families for NWD2 Gene

Suggested Antigen Peptide Sequences for NWD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULI1

UniProtKB/Swiss-Prot:

NWD2_HUMAN :
  • Contains 1 NACHT domain.
  • Contains 5 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 NACHT domain.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
  • Contains 11 WD repeats.
genes like me logo Genes that share domains with NWD2: view

No data available for Gene Families for NWD2 Gene

Function for NWD2 Gene

Phenotypes for NWD2 Gene

genes like me logo Genes that share phenotypes with NWD2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NWD2 Gene

Localization for NWD2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NWD2 Gene

Pathways & Interactions for NWD2 Gene

SuperPathways for NWD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NWD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NWD2 Gene

Transcripts for NWD2 Gene

mRNA/cDNA for NWD2 Gene

(1) REFSEQ mRNAs :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NWD2 Gene

No ASD Table

Relevant External Links for NWD2 Gene

GeneLoc Exon Structure for
NWD2
ECgene alternative splicing isoforms for
NWD2

Expression for NWD2 Gene

mRNA expression in normal human tissues for NWD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NWD2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.3), Brain - Frontal Cortex (BA9) (x8.0), Brain - Anterior cingulate cortex (BA24) (x7.5), Brain - Cortex (x6.9), and Brain - Hypothalamus (x4.0).

Protein differential expression in normal tissues from HIPED for NWD2 Gene

This gene is overexpressed in Ovary (30.2), Heart (29.3), and Fetal heart (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NWD2 Gene



Protein tissue co-expression partners for NWD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NWD2 Gene:

NWD2
genes like me logo Genes that share expression patterns with NWD2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NWD2 Gene

Orthologs for NWD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NWD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1239 34 35
  • 99.62 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1239 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1239 34 35
  • 90.05 (n)
dog
(Canis familiaris)
Mammalia KIAA1239 34 35
  • 90.05 (n)
mouse
(Mus musculus)
Mammalia 3110047P20Rik 34 35
  • 88.17 (n)
Nwd2 16
rat
(Rattus norvegicus)
Mammalia RGD1563065 34
  • 88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1239 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1239 34 35
  • 77.27 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1239 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1239 34
  • 73.16 (n)
Str.9989 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.26394 34
zebrafish
(Danio rerio)
Actinopterygii AL935029.1 35
  • 72 (a)
OneToOne
LOC562320 34
  • 69.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10185 34 35
  • 44.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011163 34
  • 42.15 (n)
worm
(Caenorhabditis elegans)
Secernentea T05C3.2 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
ManyToMany
Species where no ortholog for NWD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NWD2 Gene

ENSEMBL:
Gene Tree for NWD2 (if available)
TreeFam:
Gene Tree for NWD2 (if available)

Paralogs for NWD2 Gene

Paralogs for NWD2 Gene

genes like me logo Genes that share paralogs with NWD2: view

Variants for NWD2 Gene

Sequence variations from dbSNP and Humsavar for NWD2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001618 -- 37,339,049(+) TTGTT(C/T)AGTCA intron-variant
rs10001922 -- 37,324,306(+) ATGTA(C/T)GATTT intron-variant
rs10001995 -- 37,315,571(+) tcaac(A/C)tattt intron-variant
rs10005045 -- 37,316,373(+) ccctt(A/G)tatgt intron-variant
rs10006730 -- 37,321,580(+) TACAC(G/T)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NWD2 Gene

Variant ID Type Subtype PubMed ID
dgv1473e212 CNV loss 25503493
dgv2960e59 CNV duplication 20981092
dgv824e201 CNV deletion 23290073
dgv825e201 CNV deletion 23290073
esv1660515 CNV deletion 17803354
esv2445355 CNV deletion 19546169
esv26310 CNV gain 19812545
esv2727416 CNV deletion 23290073
esv2727417 CNV deletion 23290073
esv2727423 CNV deletion 23290073
esv2727426 CNV deletion 23290073
esv2727427 CNV deletion 23290073
esv2727428 CNV deletion 23290073
esv2763351 CNV loss 21179565
esv3303723 CNV mobile element insertion 20981092
esv3436556 CNV insertion 20981092
esv3569378 CNV loss 25503493
nsv4302 CNV insertion 18451855
nsv471989 CNV novel sequence insertion 20440878
nsv477990 CNV novel sequence insertion 20440878
nsv516377 CNV loss 19592680
nsv528187 CNV loss 19592680

Variation tolerance for NWD2 Gene

Gene Damage Index Score: 7.71; 83.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NWD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NWD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NWD2 Gene

Disorders for NWD2 Gene

Relevant External Links for NWD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NWD2

No disorders were found for NWD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NWD2 Gene

Publications for NWD2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 4 64
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3 64

Products for NWD2 Gene

Sources for NWD2 Gene

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