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Aliases for NWD2 Gene

Aliases for NWD2 Gene

  • NACHT And WD Repeat Domain Containing 2 2 3
  • KIAA1239 2 3 4
  • Leucine-Rich Repeat And WD Repeat-Containing Protein KIAA1239 4
  • NACHT And WD Repeat Domain-Containing Protein 2 3

External Ids for NWD2 Gene

Previous Symbols for NWD2 Gene

  • KIAA1239

Summaries for NWD2 Gene

GeneCards Summary for NWD2 Gene

NWD2 (NACHT And WD Repeat Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is NWD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NWD2 Gene

Genomics for NWD2 Gene

Genomic Location for NWD2 Gene

37,244,220 bp from pter
37,449,465 bp from pter
205,246 bases
Plus strand

Genomic View for NWD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NWD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NWD2 Gene

No data available for Regulatory Elements for NWD2 Gene

Proteins for NWD2 Gene

  • Protein details for NWD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT and WD repeat domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8MRU1

    Protein attributes for NWD2 Gene

    1742 amino acids
    Molecular mass:
    197466 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NWD2 Gene

Proteomics data for NWD2 Gene at MOPED

Post-translational modifications for NWD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NWD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NWD2 Gene

Domains for NWD2 Gene


  • Contains 1 NACHT domain.:
    • Q9ULI1
  • Contains 5 LRR (leucine-rich) repeats.:
    • Q9ULI1
  • Contains 11 WD repeats.:
    • Q9ULI1
genes like me logo Genes that share domains with NWD2: view

No data available for Gene Families for NWD2 Gene

Function for NWD2 Gene

Gene Ontology (GO) - Molecular Function for NWD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NWD2: view

Phenotypes for NWD2 Gene

GenomeRNAi human phenotypes for NWD2:
genes like me logo Genes that share phenotypes with NWD2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NWD2 Gene

Localization for NWD2 Gene

No data available for Gene Ontology (GO) - Cellular Components for NWD2 Gene

Pathways for NWD2 Gene

SuperPathways for NWD2 Gene

No Data Available

Interacting Proteins for NWD2 Gene

Gene Ontology (GO) - Biological Process for NWD2 Gene


No data available for Pathways by source for NWD2 Gene

Transcripts for NWD2 Gene

mRNA/cDNA for NWD2 Gene

(1) REFSEQ mRNAs :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NWD2 Gene

No ASD Table

Relevant External Links for NWD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NWD2 Gene

mRNA expression in normal human tissues for NWD2 Gene

mRNA differential expression in normal tissues according to GTEx for NWD2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (8.3), Brain - Frontal Cortex (BA9) (8.0), Brain - Anterior cingulate cortex (BA24) (7.5), Brain - Cortex (6.9), and Brain - Hypothalamus (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NWD2 Gene

genes like me logo Genes that share expressions with NWD2: view

Orthologs for NWD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NWD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIAA1239 36
  • 99.62 (n)
  • 99.66 (a)
KIAA1239 37
  • 100 (a)
(Bos Taurus)
Mammalia KIAA1239 36
  • 90.05 (n)
  • 96.15 (a)
KIAA1239 37
  • 96 (a)
(Canis familiaris)
Mammalia KIAA1239 36
  • 90.05 (n)
  • 95.92 (a)
KIAA1239 37
  • 96 (a)
(Mus musculus)
Mammalia 3110047P20Rik 36
  • 88.17 (n)
  • 94.78 (a)
3110047P20Rik 16
3110047P20Rik 37
  • 95 (a)
(Monodelphis domestica)
Mammalia KIAA1239 37
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia KIAA1239 37
  • 76 (a)
(Rattus norvegicus)
Mammalia RGD1563065 36
  • 88 (n)
  • 94.19 (a)
(Gallus gallus)
Aves KIAA1239 36
  • 77.27 (n)
  • 83.76 (a)
KIAA1239 37
  • 85 (a)
(Anolis carolinensis)
Reptilia KIAA1239 37
  • 83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26394 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1239 36
  • 73.16 (n)
  • 77.93 (a)
Str.9989 36
(Danio rerio)
Actinopterygii AL935029.1 37
  • 72 (a)
LOC562320 36
  • 69.34 (n)
  • 73.18 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011163 36
  • 42.15 (n)
  • 28.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10185 36
  • 44.72 (n)
  • 31.28 (a)
CG10185 37
  • 23 (a)
(Caenorhabditis elegans)
Secernentea T05C3.2 37
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
Species with no ortholog for NWD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NWD2 Gene

Gene Tree for NWD2 (if available)
Gene Tree for NWD2 (if available)

Paralogs for NWD2 Gene

Paralogs for NWD2 Gene

genes like me logo Genes that share paralogs with NWD2: view

Variants for NWD2 Gene

Sequence variations from dbSNP and Humsavar for NWD2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1958 -- 37,359,195(+) TATGA(A/G)AGCAA intron-variant
rs718450 -- 37,360,846(+) CATCC(C/T)TCCAA intron-variant
rs720438 -- 37,406,195(-) TATCA(C/T)TTACT intron-variant
rs764882 -- 37,380,562(-) ATACT(A/G)TGGGT intron-variant
rs868291 -- 37,358,883(+) CCACT(C/G)TGACA intron-variant

Relevant External Links for NWD2 Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for NWD2 Gene

Disorders for NWD2 Gene

No disorders were found for NWD2 Gene.

No data available for UniProtKB/Swiss-Prot for NWD2 Gene

Publications for NWD2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3

Products for NWD2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NWD2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NWD2
    • Block miRNA regulation of NWD2 using miScript Target Protectors

    Sources for NWD2 Gene

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