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Aliases for NWD1 Gene

Aliases for NWD1 Gene

  • NACHT And WD Repeat Domain Containing 1 2 3

External Ids for NWD1 Gene

Summaries for NWD1 Gene

GeneCards Summary for NWD1 Gene

NWD1 (NACHT And WD Repeat Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is NWD2.

UniProtKB/Swiss-Prot for NWD1 Gene

  • May play a role in the control of androgen receptor (AR) protein steady-state levels.

Gene Wiki entry for NWD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NWD1 Gene

Genomics for NWD1 Gene

Genomic Location for NWD1 Gene

Start:
16,719,976 bp from pter
End:
16,817,963 bp from pter
Size:
97,988 bases
Orientation:
Plus strand

Genomic View for NWD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NWD1 Gene

Regulatory Elements for NWD1 Gene

Proteins for NWD1 Gene

  • Protein details for NWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q149M9-NWD1_HUMAN
    Recommended name:
    NACHT domain- and WD repeat-containing protein 1
    Protein Accession:
    Q149M9
    Secondary Accessions:
    • C9J021
    • Q68CT3

    Protein attributes for NWD1 Gene

    Size:
    1564 amino acids
    Molecular mass:
    174552 Da
    Quaternary structure:
    • May interact with HSP90AA1, HSP90AB1 and BAG2.
    SequenceCaution:
    • Sequence=AAI17699.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NWD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NWD1 Gene

Proteomics data for NWD1 Gene at MOPED

Post-translational modifications for NWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NWD1 Gene

No data available for DME Specific Peptides for NWD1 Gene

Domains for NWD1 Gene

Gene Families for NWD1 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

NWD1_HUMAN
Domain:
  • Contains 1 NACHT domain.:
    • Q149M9
Similarity:
  • Contains 14 WD repeats.:
    • Q149M9
genes like me logo Genes that share domains with NWD1: view

Function for NWD1 Gene

Molecular function for NWD1 Gene

UniProtKB/Swiss-Prot Function: May play a role in the control of androgen receptor (AR) protein steady-state levels.
UniProtKB/Swiss-Prot Induction: May be up-regulated by SOX9 and SRY.

Gene Ontology (GO) - Molecular Function for NWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NWD1: view

Phenotypes for NWD1 Gene

genes like me logo Genes that share phenotypes with NWD1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NWD1 Gene

Localization for NWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NWD1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NWD1 Gene COMPARTMENTS Subcellular localization image for NWD1 gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NWD1 Gene

Pathways for NWD1 Gene

SuperPathways for NWD1 Gene

No Data Available

Interacting Proteins for NWD1 Gene

Gene Ontology (GO) - Biological Process for NWD1 Gene

None

No data available for Pathways by source for NWD1 Gene

Transcripts for NWD1 Gene

Unigene Clusters for NWD1 Gene

NACHT and WD repeat domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NWD1 Gene

No ASD Table

Relevant External Links for NWD1 Gene

GeneLoc Exon Structure for
NWD1
ECgene alternative splicing isoforms for
NWD1

Expression for NWD1 Gene

mRNA expression in normal human tissues for NWD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NWD1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.0), Brain - Caudate (basal ganglia) (5.7), Brain - Amygdala (4.9), and Brain - Hippocampus (4.1).

SOURCE GeneReport for Unigene cluster for NWD1 Gene Hs.406014

mRNA Expression by UniProt/SwissProt for NWD1 Gene

Q149M9-NWD1_HUMAN
Tissue specificity: Expressed at highest levels in prostate, followed by testis, retina, trachea and optic nerve. Also detected in brain, epididymis, lung, vagina and pituitary. In the prostate, tends to be up-regulated during malignant progression compared to normal epithelium (at protein level).
genes like me logo Genes that share expressions with NWD1: view

Orthologs for NWD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NWD1 36
  • 97.53 (n)
  • 96.68 (a)
NWD1 37
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NWD1 36
  • 84.14 (n)
  • 82.09 (a)
NWD1 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NWD1 36
  • 84.84 (n)
  • 83.26 (a)
NWD1 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nwd1 36
  • 78.61 (n)
  • 77.48 (a)
Nwd1 16
Nwd1 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NWD1 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NWD1 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100364350 36
  • 75.65 (n)
  • 73.47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nwd1 36
  • 53.53 (n)
  • 45.7 (a)
zebrafish
(Danio rerio)
Actinopterygii CR352328.3 37
  • 16 (a)
OneToMany
LOC100330908 36
  • 49.35 (n)
  • 38.55 (a)
nwd1 37
  • 32 (a)
OneToMany
nwd1 37
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10185 37
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T05C3.2 37
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToOne
Species with no ortholog for NWD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NWD1 Gene

ENSEMBL:
Gene Tree for NWD1 (if available)
TreeFam:
Gene Tree for NWD1 (if available)

Paralogs for NWD1 Gene

Paralogs for NWD1 Gene

genes like me logo Genes that share paralogs with NWD1: view

Variants for NWD1 Gene

Sequence variations from dbSNP and Humsavar for NWD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs706763 -- 16,749,581(-) CGTCC(A/G)CAGAA reference, synonymous-codon
rs706764 - 16,749,294(-) ATCAG(C/T)GTCCA missense, reference
rs773835 -- 16,773,101(-) ACTAA(A/G)TTGCC intron-variant
rs773836 -- 16,772,140(-) tatcc(A/T)ccttc intron-variant
rs773837 -- 16,771,610(-) TTAAA(A/C)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NWD1 Gene

Variant ID Type Subtype PubMed ID
nsv911168 CNV Loss 21882294
esv2660627 CNV Deletion 23128226

Relevant External Links for NWD1 Gene

HapMap Linkage Disequilibrium report
NWD1

Disorders for NWD1 Gene

Relevant External Links for NWD1

Genetic Association Database (GAD)
NWD1
Human Genome Epidemiology (HuGE) Navigator
NWD1
genes like me logo Genes that share disorders with NWD1: view

No data available for UniProtKB/Swiss-Prot for NWD1 Gene

Publications for NWD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. (PMID: 24681825) Correa R.G. … Reed J.C. (Oncotarget 2014) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for NWD1 Gene

Sources for NWD1 Gene

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