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Aliases for NWD1 Gene

Aliases for NWD1 Gene

  • NACHT And WD Repeat Domain Containing 1 2 3 5

External Ids for NWD1 Gene

Previous GeneCards Identifiers for NWD1 Gene

  • GC19P016692
  • GC19P016830
  • GC19P016399

Summaries for NWD1 Gene

Entrez Gene Summary for NWD1 Gene

  • The protein encoded by this gene is thought to be a cytosolic protein and predicted to contain a NACHT domain and multiple WD40 repeats. Increased expression of this gene was observed in some prostate cancer cell lines. Knocking down expression of this gene results in decreased androgen receptor protein levels, indicating that this gene may be important in modulating androgen receptor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

GeneCards Summary for NWD1 Gene

NWD1 (NACHT And WD Repeat Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is NWD2.

UniProtKB/Swiss-Prot for NWD1 Gene

  • May play a role in the control of androgen receptor (AR) protein steady-state levels.

Gene Wiki entry for NWD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NWD1 Gene

Genomics for NWD1 Gene

Regulatory Elements for NWD1 Gene

Enhancers for NWD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G016717 1.3 Ensembl ENCODE 16 -0.7 -694 3.0 HDGF PKNOX1 ATF1 ARNT SIN3A YY1 GLIS2 GATA2 KLF7 KLF13 NWD1 GC19M016713
GH19G016733 1 Ensembl ENCODE 10.3 +14.4 14387 1.7 SAP130 ARID4B FEZF1 ZNF121 GATA3 PATZ1 SCRT2 ZNF600 PRDM10 SCRT1 SIN3B CPAMD8 NWD1 GC19M016767
GH19G016341 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -377.3 -377339 2.6 HDGF PKNOX1 INSM2 FEZF1 RAD21 ZNF335 EGR1 RELB ETV6 IKZF2 KLF2 C19orf44 MED26 NWD1 ENSG00000277825
GH19G016253 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -466.1 -466061 0.9 BCOR HDGF ZNF777 ARNT SUZ12 ZNF175 MAX ZMYM3 YBX1 CDC5L AP1M1 NWD1 GC19M016240 PIR54763
GH19G016282 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -435.0 -435049 5.4 NFXL1 ZNF2 EGR1 ZNF366 CREM EGR2 SMARCA5 ZNF654 MCM3 ZBTB11 KLF2 NWD1 PIR54763 GC19M016240
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NWD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NWD1 Gene

Chromosome:
19
Start:
16,719,853 bp from pter
End:
16,817,963 bp from pter
Size:
98,111 bases
Orientation:
Plus strand

Genomic View for NWD1 Gene

Genes around NWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NWD1 Gene

Proteins for NWD1 Gene

  • Protein details for NWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q149M9-NWD1_HUMAN
    Recommended name:
    NACHT domain- and WD repeat-containing protein 1
    Protein Accession:
    Q149M9
    Secondary Accessions:
    • C9J021
    • Q68CT3

    Protein attributes for NWD1 Gene

    Size:
    1564 amino acids
    Molecular mass:
    174552 Da
    Quaternary structure:
    • May interact with HSP90AA1, HSP90AB1 and BAG2.
    SequenceCaution:
    • Sequence=AAI17699.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NWD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NWD1 Gene

Post-translational modifications for NWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NWD1 Gene

Domains & Families for NWD1 Gene

Gene Families for NWD1 Gene

Suggested Antigen Peptide Sequences for NWD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NWD1: view

No data available for UniProtKB/Swiss-Prot for NWD1 Gene

Function for NWD1 Gene

Molecular function for NWD1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the control of androgen receptor (AR) protein steady-state levels.
UniProtKB/Swiss-Prot Induction:
May be up-regulated by SOX9 and SRY.

Gene Ontology (GO) - Molecular Function for NWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NWD1: view
genes like me logo Genes that share phenotypes with NWD1: view

Animal Model Products

CRISPR Products

miRNA for NWD1 Gene

miRTarBase miRNAs that target NWD1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NWD1 Gene

Localization for NWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NWD1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NWD1 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005682 U5 snRNP IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0071011 precatalytic spliceosome IBA --
GO:0071013 catalytic step 2 spliceosome IBA --
genes like me logo Genes that share ontologies with NWD1: view

Pathways & Interactions for NWD1 Gene

No Data Available

Interacting Proteins for NWD1 Gene

Gene Ontology (GO) - Biological Process for NWD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008380 RNA splicing IBA --
genes like me logo Genes that share ontologies with NWD1: view

No data available for Pathways by source and SIGNOR curated interactions for NWD1 Gene

Drugs & Compounds for NWD1 Gene

No Compound Related Data Available

Transcripts for NWD1 Gene

Unigene Clusters for NWD1 Gene

NACHT and WD repeat domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NWD1 Gene

No ASD Table

Relevant External Links for NWD1 Gene

GeneLoc Exon Structure for
NWD1
ECgene alternative splicing isoforms for
NWD1

Expression for NWD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NWD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NWD1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.7), Brain - Amygdala (x4.9), and Brain - Hippocampus (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of NWD1 Gene:

NWD1

SOURCE GeneReport for Unigene cluster for NWD1 Gene:

Hs.406014

mRNA Expression by UniProt/SwissProt for NWD1 Gene:

Q149M9-NWD1_HUMAN
Tissue specificity: Expressed at highest levels in prostate, followed by testis, retina, trachea and optic nerve. Also detected in brain, epididymis, lung, vagina and pituitary. In the prostate, tends to be up-regulated during malignant progression compared to normal epithelium (at protein level).

Evidence on tissue expression from TISSUES for NWD1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with NWD1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NWD1 Gene

Orthologs for NWD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NWD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NWD1 35 34
  • 97.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NWD1 34 35
  • 84.84 (n)
cow
(Bos Taurus)
Mammalia NWD1 34 35
  • 84.14 (n)
mouse
(Mus musculus)
Mammalia Nwd1 34 16 35
  • 78.61 (n)
rat
(Rattus norvegicus)
Mammalia LOC100364350 34
  • 75.65 (n)
oppossum
(Monodelphis domestica)
Mammalia NWD1 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NWD1 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nwd1 34
  • 53.53 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330908 34
  • 49.35 (n)
nwd1 35 35
  • 32 (a)
OneToMany
CR352328.3 35
  • 16 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10185 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T05C3.2 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for NWD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NWD1 Gene

ENSEMBL:
Gene Tree for NWD1 (if available)
TreeFam:
Gene Tree for NWD1 (if available)

Paralogs for NWD1 Gene

Paralogs for NWD1 Gene

genes like me logo Genes that share paralogs with NWD1: view

Variants for NWD1 Gene

Sequence variations from dbSNP and Humsavar for NWD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs193920843 Uncertain significance 16,800,094(+) CCACA(A/G)TGGAA downstream-variant-500B, reference, missense
rs1000070671 -- 16,760,695(+) CAGCG(A/G)TTCTC intron-variant
rs1000100392 -- 16,780,219(+) GGTGC(A/C)ATCTC intron-variant
rs1000156594 -- 16,738,210(+) TGACT(G/T)TCTGA intron-variant
rs1000174586 -- 16,809,736(+) ATTTT(C/T)TTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NWD1 Gene

Variant ID Type Subtype PubMed ID
esv2660627 CNV deletion 23128226
esv3556107 CNV deletion 23714750
esv3643804 CNV loss 21293372
nsv1071512 CNV deletion 25765185
nsv1072335 CNV deletion 25765185
nsv1134761 CNV deletion 24896259
nsv1144868 CNV deletion 24896259
nsv475160 CNV novel sequence insertion 20440878

Variation tolerance for NWD1 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.67; 97.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NWD1 Gene

Human Gene Mutation Database (HGMD)
NWD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NWD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NWD1 Gene

Disorders for NWD1 Gene

Relevant External Links for NWD1

Genetic Association Database (GAD)
NWD1
Human Genome Epidemiology (HuGE) Navigator
NWD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NWD1

No disorders were found for NWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NWD1 Gene

Publications for NWD1 Gene

  1. The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. (PMID: 24681825) Correa R.G. … Reed J.C. (Oncotarget 2014) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population. (PMID: 26706132) Watanabe Y. … Someya T. (Psychiatry Res 2016) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for NWD1 Gene

Sources for NWD1 Gene

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