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Aliases for NWD1 Gene

Aliases for NWD1 Gene

  • NACHT And WD Repeat Domain Containing 1 2 3 5

External Ids for NWD1 Gene

Previous GeneCards Identifiers for NWD1 Gene

  • GC19P016692
  • GC19P016830
  • GC19P016399

Summaries for NWD1 Gene

GeneCards Summary for NWD1 Gene

NWD1 (NACHT And WD Repeat Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is NWD2.

UniProtKB/Swiss-Prot for NWD1 Gene

  • May play a role in the control of androgen receptor (AR) protein steady-state levels.

Gene Wiki entry for NWD1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NWD1 Gene

Genomics for NWD1 Gene

Regulatory Elements for NWD1 Gene

Enhancers for NWD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NWD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NWD1 Gene

16,719,853 bp from pter
16,817,963 bp from pter
98,111 bases
Plus strand

Genomic View for NWD1 Gene

Genes around NWD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NWD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NWD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NWD1 Gene

Proteins for NWD1 Gene

  • Protein details for NWD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT domain- and WD repeat-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • C9J021
    • Q68CT3

    Protein attributes for NWD1 Gene

    1564 amino acids
    Molecular mass:
    174552 Da
    Quaternary structure:
    • May interact with HSP90AA1, HSP90AB1 and BAG2.
    • Sequence=AAI17699.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for NWD1 Gene


neXtProt entry for NWD1 Gene

Proteomics data for NWD1 Gene at MOPED

Post-translational modifications for NWD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NWD1 Gene

No data available for DME Specific Peptides for NWD1 Gene

Domains & Families for NWD1 Gene

Gene Families for NWD1 Gene

Suggested Antigen Peptide Sequences for NWD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 NACHT domain.
  • Contains 14 WD repeats.
  • Contains 1 NACHT domain.
  • Contains 14 WD repeats.
genes like me logo Genes that share domains with NWD1: view

Function for NWD1 Gene

Molecular function for NWD1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the control of androgen receptor (AR) protein steady-state levels.
UniProtKB/Swiss-Prot Induction:
May be up-regulated by SOX9 and SRY.
genes like me logo Genes that share phenotypes with NWD1: view

Animal Model Products

miRNA for NWD1 Gene

miRTarBase miRNAs that target NWD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NWD1 Gene

Localization for NWD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NWD1 Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for NWD1 Gene COMPARTMENTS Subcellular localization image for NWD1 gene
Compartment Confidence
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NWD1 Gene

Pathways & Interactions for NWD1 Gene

SuperPathways for NWD1 Gene

No Data Available

Interacting Proteins for NWD1 Gene

Gene Ontology (GO) - Biological Process for NWD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for NWD1 Gene

Drugs & Compounds for NWD1 Gene

No Compound Related Data Available

Transcripts for NWD1 Gene

Unigene Clusters for NWD1 Gene

NACHT and WD repeat domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NWD1 Gene

No ASD Table

Relevant External Links for NWD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NWD1 Gene

mRNA expression in normal human tissues for NWD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NWD1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.0), Brain - Caudate (basal ganglia) (x5.7), Brain - Amygdala (x4.9), and Brain - Hippocampus (x4.1).

SOURCE GeneReport for Unigene cluster for NWD1 Gene Hs.406014

mRNA Expression by UniProt/SwissProt for NWD1 Gene

Tissue specificity: Expressed at highest levels in prostate, followed by testis, retina, trachea and optic nerve. Also detected in brain, epididymis, lung, vagina and pituitary. In the prostate, tends to be up-regulated during malignant progression compared to normal epithelium (at protein level).
genes like me logo Genes that share expression patterns with NWD1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NWD1 Gene

Orthologs for NWD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NWD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NWD1 35
  • 84.14 (n)
  • 82.09 (a)
NWD1 36
  • 74 (a)
(Canis familiaris)
Mammalia NWD1 35
  • 84.84 (n)
  • 83.26 (a)
NWD1 36
  • 76 (a)
(Mus musculus)
Mammalia Nwd1 35
  • 78.61 (n)
  • 77.48 (a)
Nwd1 16
Nwd1 36
  • 70 (a)
(Pan troglodytes)
Mammalia NWD1 35
  • 97.53 (n)
  • 96.68 (a)
NWD1 36
  • 87 (a)
(Rattus norvegicus)
Mammalia LOC100364350 35
  • 75.65 (n)
  • 73.47 (a)
(Monodelphis domestica)
Mammalia NWD1 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia NWD1 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nwd1 35
  • 53.53 (n)
  • 45.7 (a)
(Danio rerio)
Actinopterygii LOC100330908 35
  • 49.35 (n)
  • 38.55 (a)
CR352328.3 36
  • 16 (a)
nwd1 36
  • 32 (a)
nwd1 36
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10185 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea T05C3.2 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for NWD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NWD1 Gene

Gene Tree for NWD1 (if available)
Gene Tree for NWD1 (if available)

Paralogs for NWD1 Gene

Paralogs for NWD1 Gene

genes like me logo Genes that share paralogs with NWD1: view

Variants for NWD1 Gene

Sequence variations from dbSNP and Humsavar for NWD1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3888834 - 16,749,162(+) AGCGG(A/G)GCCTG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs11668502 - 16,749,273(+) ACCGG(C/T)TCGCG upstream-variant-2KB, reference, missense
rs706764 - 16,749,294(-) ATCAG(C/T)GTCCA upstream-variant-2KB, reference, missense
rs773930 - 16,779,432(-) ATGCT(C/G)CTCTT reference, missense
rs2608737 - 16,789,027(+) CGCCA(A/T)CTCTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NWD1 Gene

Variant ID Type Subtype PubMed ID
nsv911168 CNV Loss 21882294
esv2660627 CNV Deletion 23128226

Variation tolerance for NWD1 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.67; 97.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NWD1 Gene

Disorders for NWD1 Gene

Relevant External Links for NWD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NWD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NWD1 Gene

Publications for NWD1 Gene

  1. The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. (PMID: 24681825) Correa R.G. … Reed J.C. (Oncotarget 2014) 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for NWD1 Gene

Sources for NWD1 Gene