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Aliases for NVL Gene

Aliases for NVL Gene

  • Nuclear VCP-Like 2 3
  • Nuclear Valosin-Containing Protein-Like 2 3
  • Nuclear VCP-Like Protein 2 4
  • NVLp 3 4

External Ids for NVL Gene

Previous GeneCards Identifiers for NVL Gene

  • GC01M222845
  • GC01M220232
  • GC01M220822
  • GC01M221389
  • GC01M220721
  • GC01M222482
  • GC01M224416
  • GC01M194934

Summaries for NVL Gene

Entrez Gene Summary for NVL Gene

  • This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]

GeneCards Summary for NVL Gene

NVL (Nuclear VCP-Like) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include nucleoside-triphosphatase activity.

Gene Wiki entry for NVL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NVL Gene

Genomics for NVL Gene

Regulatory Elements for NVL Gene

Genomic Location for NVL Gene

Start:
224,227,334 bp from pter
End:
224,330,387 bp from pter
Size:
103,054 bases
Orientation:
Minus strand

Genomic View for NVL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NVL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NVL Gene

Proteins for NVL Gene

  • Protein details for NVL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15381-NVL_HUMAN
    Recommended name:
    Nuclear valosin-containing protein-like
    Protein Accession:
    O15381
    Secondary Accessions:
    • B4DMC4
    • B4DP98
    • Q96EM7

    Protein attributes for NVL Gene

    Size:
    856 amino acids
    Molecular mass:
    95051 Da
    Quaternary structure:
    • Interacts with NCL/nucleolin.

    Three dimensional structures from OCA and Proteopedia for NVL Gene

    Alternative splice isoforms for NVL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NVL Gene

Proteomics data for NVL Gene at MOPED

Post-translational modifications for NVL Gene

  • Ubiquitination at Lys759
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NVL Gene

Domains for NVL Gene

Gene Families for NVL Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for NVL Gene

Graphical View of Domain Structure for InterPro Entry

O15381

UniProtKB/Swiss-Prot:

NVL_HUMAN :
  • O15381
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with NVL: view

Function for NVL Gene

Molecular function for NVL Gene

GENATLAS Biochemistry: nuclear valosin containing protein like 1,with two alternatively spliced forms NVL1,83kDa,not phosphorylated,NVL2 phosphorylated,95-110kDa

Gene Ontology (GO) - Molecular Function for NVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0009378 four-way junction helicase activity --
GO:0016301 kinase activity --
GO:0016887 ATPase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NVL: view
genes like me logo Genes that share phenotypes with NVL: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NVL Gene

Localization for NVL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NVL Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NVL Gene COMPARTMENTS Subcellular localization image for NVL gene
Compartment Confidence
nucleus 5
cytosol 3
chloroplast 1

Gene Ontology (GO) - Cellular Components for NVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NVL: view

Pathways for NVL Gene

genes like me logo Genes that share pathways with NVL: view

Pathways by source for NVL Gene

1 KEGG pathway for NVL Gene

Gene Ontology (GO) - Biological Process for NVL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair --
GO:0006310 DNA recombination --
genes like me logo Genes that share ontologies with NVL: view

Transcripts for NVL Gene

Unigene Clusters for NVL Gene

Nuclear VCP-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NVL Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b · 8c ^ 9 ^
SP1: - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - -
SP5:
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9: -
SP10: - - - - -
SP11: - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - -
SP15:
SP16:
SP17:

ExUns: 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -

Relevant External Links for NVL Gene

GeneLoc Exon Structure for
NVL
ECgene alternative splicing isoforms for
NVL

Expression for NVL Gene

mRNA expression in normal human tissues for NVL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NVL Gene

SOURCE GeneReport for Unigene cluster for NVL Gene Hs.497867

mRNA Expression by UniProt/SwissProt for NVL Gene

O15381-NVL_HUMAN
Tissue specificity: Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
genes like me logo Genes that share expressions with NVL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NVL Gene

Orthologs for NVL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NVL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NVL 35
  • 99.72 (n)
  • 99.64 (a)
cow
(Bos Taurus)
Mammalia NVL 35
  • 89.82 (n)
  • 89.82 (a)
NVL 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NVL 35
  • 84.32 (n)
  • 87.38 (a)
NVL 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nvl 35
  • 86.67 (n)
  • 87.95 (a)
Nvl 16
Nvl 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NVL 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NVL 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nvl 35
  • 84.76 (n)
  • 85.73 (a)
chicken
(Gallus gallus)
Aves NVL 35
  • 73.02 (n)
  • 76.88 (a)
NVL 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NVL 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52979 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nvl 35
  • 68.15 (n)
  • 73.82 (a)
zebrafish
(Danio rerio)
Actinopterygii nvl 35
  • 63.5 (n)
  • 68.1 (a)
nvl 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006205 35
  • 55.42 (n)
  • 57.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta smid 35
  • 52.47 (n)
  • 47.78 (a)
smid 36
  • 39 (a)
OneToOne
smid 37
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea mac-1 35
  • 57.25 (n)
  • 55.44 (a)
mac-1 36
  • 44 (a)
OneToOne
mac-1 37
  • 50 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR188W 35
  • 54.85 (n)
  • 53.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIX7 35
  • 54.17 (n)
  • 52.53 (a)
RIX7 36
  • 41 (a)
OneToOne
RIX7 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E00837g 35
  • 55.96 (n)
  • 53.95 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CDC48C 35
  • 54.98 (n)
  • 48.66 (a)
rice
(Oryza sativa)
Liliopsida Os06g0109400 35
  • 54.32 (n)
  • 48.38 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC16E9.10c 35
  • 55.8 (n)
  • 54.21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9449 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for NVL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NVL Gene

ENSEMBL:
Gene Tree for NVL (if available)
TreeFam:
Gene Tree for NVL (if available)

Paralogs for NVL Gene

genes like me logo Genes that share paralogs with NVL: view

No data available for Paralogs for NVL Gene

Variants for NVL Gene

Sequence variations from dbSNP and Humsavar for NVL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs908797 -- 224,247,067(-) ttttt(G/T)ttttt intron-variant
rs925927 -- 224,251,933(-) ATAAC(A/G)CTAGC intron-variant
rs925928 -- 224,248,396(-) GCTTG(A/G)AAGCC intron-variant
rs1401318 -- 224,233,464(-) TCTTA(C/T)ATAAA intron-variant
rs1533589 -- 224,245,320(-) GCAGA(G/T)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NVL Gene

Variant ID Type Subtype PubMed ID
nsv873223 CNV Gain 21882294
nsv8868 CNV Loss 18304495
nsv469889 CNV Complex 16826518
esv2723739 CNV Deletion 23290073
esv2723750 CNV Deletion 23290073
esv2328653 CNV Deletion 18987734

Relevant External Links for NVL Gene

HapMap Linkage Disequilibrium report
NVL
Human Gene Mutation Database (HGMD)
NVL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NVL Gene

Disorders for NVL Gene

Relevant External Links for NVL

Genetic Association Database (GAD)
NVL
Human Genome Epidemiology (HuGE) Navigator
NVL
genes like me logo Genes that share disorders with NVL: view

No data available for UniProtKB/Swiss-Prot for NVL Gene

Publications for NVL Gene

  1. NVL: a new member of the AAA family of ATPases localized to the nucleus. (PMID: 9286697) Germain-Lee E.L. … Valle D. (Genomics 1997) 2 3 4 23
  2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48
  4. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. (PMID: 21042317) Wray N.R. … Sullivan P.F. (Mol. Psychiatry 2012) 3 48
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4

Products for NVL Gene

Sources for NVL Gene

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