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NUTM2G Gene

protein-coding   GIFtS: 22
GCID: GC09P099691

NUT Family Member 2G

(Previous names: family with sequence similarity 22, member G)
(Previous symbol: FAM22G)
  Search for NUTM2G
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NUT Family Member 2G1 2
FAM22G1 2 3
Family With Sequence Similarity 22, Member G1 2
NUTMG2
Family With Sequence Similarity 22, Pseudogene2
Protein FAM22G2

External Ids:    HGNC: 234491   Entrez Gene: 4414572   Ensembl: ENSG000001881527   UniProtKB: Q5VZR23   

Export aliases for NUTM2G gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUTM2G Gene:
NUTM2G (NUT family member 2G) is a protein-coding gene. An important paralog of this gene is NUTM1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NUTM2G
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NUTM2G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUTM2G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.33

NUTM2G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUTM2G gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P099691:  view genomic region     (about GC identifiers)

Start:
99,690,592 bp from pter      End:
99,704,572 bp from pter
Size:
13,981 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NTM2G_HUMAN, Q5VZR2 (See protein sequence)
Recommended Name: NUT family member 2G  
Size: 741 amino acids; 79011 Da
Secondary accessions: A6NNI5 Q5VZR3
Alternative splicing: 2 isoforms:  Q5VZR2-1   Q5VZR2-2   

Explore the universe of human proteins at neXtProt for NUTM2G: NX_Q5VZR2

Explore proteomics data for NUTM2G at MOPED


See NUTM2G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001038942.1  NP_001164212.1  

ENSEMBL proteins: 
 ENSP00000346670   ENSP00000361397  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR024309 NUT_N
 IPR024310 NUT/FAM22
 IPR024313 NUT_C

Graphical View of Domain Structure for InterPro Entry Q5VZR2

ProtoNet protein and cluster: Q5VZR2

UniProtKB/Swiss-Prot: NTM2G_HUMAN, Q5VZR2
Similarity: Belongs to the NUT family


Find genes that share domains with NUTM2G           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUTM2G
Interactions:

    Search GeneGlobe Interaction Network for NUTM2G

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for NUTM2G (NTM2G)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NUTM2G gene (2 alternative transcripts): 
NM_001045477.2  NM_001170741.1  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000354649(uc004awq.2) ENST00000372322(uc022bkp.1)
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3 AceView cDNA sequences:

BV197523 BV197525 BV197524 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NUTM2G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NUTM2G Expression
About this image

NUTM2G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NUTM2G Protein Expression
    Custom PCR Arrays for NUTM2G
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUTM2G

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NUTM2G gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
50(a)
1 → many
GL343220.1(852503-857458)
        Species with no ortholog for NUTM2G

ENSEMBL Gene Tree for NUTM2G (if available)
TreeFam Gene Tree for NUTM2G (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NUTM2G gene
NUTM2F1 2  NUTM12  NUTM2D2  NUTM2A2  NUTM2B2  NUTM2E2  
7 SIMAP similar genes for NUTM2G using alignment to 1 protein entry:     NTM2G_HUMAN:
NUTM2F    FAM22F    NUTM2A    NUTM2B    NUTM2D    NUTM2E
NUTM1

Find genes that share paralogs with NUTM2G           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NUTM2G (see all 288)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1412869231,2
--99689286(+) CTTTGA/GCCAGT 2 -- us2k10--------
rs1121780931,2
F--99689327(+) AACATC/GAGTGC 2 -- us2k11Minor allele frequency- G:0.00CSA 1
rs2016527491,2
C--99689347(+) TCATTC/TTGACG 2 -- us2k10--------
rs1429357421,2
C--99689716(+) AGAACA/GGTATA 2 -- us2k10--------
rs1474008201,2
--99689730(+) GCTACA/TCCTGA 2 -- us2k10--------
rs1887021341,2
--99689769(+) GTTTTC/TTGCAA 2 -- us2k10--------
rs1152742531,2
C,F--99689982(+) GTACTG/CTAAAT 2 -- us2k12Minor allele frequency- C:0.47WA EA 238
rs2001936751,2
C--99690339(+) ATCAGA/GTAACA 2 -- us2k10--------
rs2014971061,2
--99691265(+) ATTGCA/GGAAGC 2 -- us2k10--------
rs1445371641,2
C--99691351(+) TATCCG/TAGTCT 2 -- int10--------

HapMap Linkage Disequilibrium report for NUTM2G (99690592 - 99704572 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NUTM2G: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NUTM2G
DNA2.0 Custom Variant and Variant Library Synthesis for NUTM2G

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for NUTM2G gene integrated from 10 sources:
(articles sorted by number of sources associating them with NUTM2G)
    Utopia: connect your pdf to the dynamic
world of online information

  1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 441457 HGNC: 23449 AceView: LOC441457 Ensembl:ENSG00000188152 euGenes: HUgn441457
ECgene: NUTM2G H-InvDB: NUTM2G

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NUTM2G Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NUTM2G gene:
Search GeneIP for patents involving NUTM2G

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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