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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUTM2D Gene

protein-coding   GIFtS: 25
GCID: GC10P089120

NUT Family Member 2D

(Previous names: family with sequence similarity 22, member D)
(Previous symbol: FAM22D)
  Search for NUTM2D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NUT Family Member 2D1 2
FAM22D1 2 3
Family With Sequence Similarity 22, Member D1

External Ids:    HGNC: 234471   Entrez Gene: 7281302   Ensembl: ENSG000002145627   UniProtKB: Q5VT033   

Export aliases for NUTM2D gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NUTM2D Gene: 
NUTM2D (NUT family member 2D) is a protein-coding gene. An important paralog of this gene is NUTM1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NUTM2D
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NUTM2D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUTM2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.31

NUTM2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUTM2D gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P089120:  view genomic region     (about GC identifiers)

Start:
89,117,425 bp from pter      End:
89,130,452 bp from pter
Size:
13,028 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTM2D_HUMAN, Q5VT03 (See protein sequence)
Recommended Name: NUT family member 2D  
Size: 806 amino acids; 86276 Da
Secondary accessions: A6NGV9
Alternative splicing: 2 isoforms:  Q5VT03-1   Q5VT03-2   

Explore the universe of human proteins at neXtProt for NUTM2D: NX_Q5VT03

Explore proteomics data for NUTM2D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VT03

  • NUTM2D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUTM2D Protein Expression

    ENSEMBL proteins: 
     ENSP00000371116   ENSP00000396080   ENSP00000475197  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR024309 NUT_N
     IPR024310 NUT/FAM22
     IPR024313 NUT_C

    Graphical View of Domain Structure for InterPro Entry Q5VT03

    ProtoNet protein and cluster: Q5VT03

    UniProtKB/Swiss-Prot: NTM2D_HUMAN, Q5VT03
    Similarity: Belongs to the NUT family


    NUTM2D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUTM2D

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUTM2D (NTM2D)

    Search CenterWatch for drugs/clinical trials and news about NUTM2D / NTM2D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUTM2D gene: 
    NM_001009610.1  

    Unigene Cluster for NUTM2D:

    NUT family member 2D
    Hs.701044  [show with all ESTs]
    Unigene Representative Sequence: NR_075100
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381697(uc001kes.3) ENST00000412718(uc009xte.1) ENST00000465545

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    Additional mRNA sequence: NR_075100.1 

    4 DOTS entries:

    DT.102838481  DT.208297  DT.91895673  DT.97810837 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See NUTM2D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUTM2D

    SOURCE GeneReport for Unigene cluster: Hs.701044
        SABiosciences Custom PCR Arrays for NUTM2D
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUTM2D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NUTM2D gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    42(a)
    1 → many
    GL343220.1(852503-857458)
            Species with no ortholog for NUTM2D

    ENSEMBL Gene Tree for NUTM2D (if available)
    TreeFam Gene Tree for NUTM2D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUTM2D gene
    NUTM12  NUTM2G2  NUTM2F2  NUTM2A2  NUTM2B2  NUTM2E2  
    7 SIMAP similar genes for NUTM2D using alignment to 1 protein entry:     NTM2D_HUMAN:
    NUTM2A    NUTM2B    NUTM2E    FAM22F    NUTM2F    NUTM2G
    NUTM1

    NUTM2D for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NUTM2D
    PGOHUM00000262858


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 SNPs in NUTM2D are shown (see all 100)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2000943241,2
    C--89115741(+) TTCACA/GTTGAT 1 -- us2k10--------
    rs2003107891,2
    C--89115826(+) GTGGAA/GGAGCA 1 -- us2k10--------
    rs1473567621,2
    C--89115976(+) TTACCC/TTTGGC 1 -- us2k10--------
    rs2022275931,2
    C--89116126(+) GCCACA/GTGTGA 1 -- us2k10--------
    rs2015122201,2
    C--89117072(+) AATGAA/CGTTTT 1 -- us2k10--------
    rs3707563751,2
    C--89117852(+) TGAGT-/AGAGAAGG 1 -- nc-transcript-variant0--------
    rs2010730491,2
    C--89118023(+) GTCCTA/GTGTTC 1 -- nc-transcript-variant0--------
    rs771531161,2
    C,F--89118125(+) TTTCTC/TATTGT 1 -- nc-transcript-variant5Minor allele frequency- T:0.20NA WA EU 1433
    rs2020830891,2
    C--89118409(+) GGGGG-/AATACA 1 -- int10--------
    rs1932650571,2
    --89120525(+) TGGTCC/TTAACT 1 -- nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for NUTM2D (89117425 - 89130452 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NUTM2D: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NUTM2D
    DNA2.0 Custom Variant and Variant Library Synthesis for NUTM2D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for NUTM2D gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NUTM2D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 728130 HGNC: 23447 Ensembl:ENSG00000214562 euGenes: HUgn728130 ECgene: NUTM2D
    H-InvDB: NUTM2D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUTM2D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUTM2D gene:
    Search GeneIP for patents involving NUTM2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    transforming growth factor, beta 1
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