Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUTM2B Gene

Aliases for NUTM2B Gene

  • NUT Family Member 2B 2 3 5
  • Family With Sequence Similarity 22, Member B 2 3
  • FAM22B 3 4
  • Protein FAM22B 3
  • BA119F19.1 3

External Ids for NUTM2B Gene

Previous HGNC Symbols for NUTM2B Gene

  • FAM22B

Previous GeneCards Identifiers for NUTM2B Gene

  • GC10P081479
  • GC10P081573
  • GC10P080039
  • GC10P080065
  • GC10P080089
  • GC10P080111
  • GC10P080136
  • GC10P080158

Summaries for NUTM2B Gene

GeneCards Summary for NUTM2B Gene

NUTM2B (NUT Family Member 2B) is a Protein Coding gene. Diseases associated with NUTM2B include Kidney Clear Cell Sarcoma and Endometrial Stromal Sarcoma. An important paralog of this gene is NUTM2E.

Additional gene information for NUTM2B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTM2B Gene

Genomics for NUTM2B Gene

Regulatory Elements for NUTM2B Gene

Enhancers for NUTM2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H079110 1.5 Ensembl ENCODE dbSUPER 9.7 -585.4 -585397 6.6 PKNOX1 ATF1 FOXA2 ARNT ARID4B GLI4 TCF12 ZNF766 FOS RUNX3 PGGT1BP2 NPAP1P2 ENSG00000272489 NUTM2B ZMIZ1 GC10M079169
GH10H079825 0.9 ENCODE 9 +127.4 127401 2.2 HDAC1 PKNOX1 ATF1 ZNF76 SIN3A SCRT2 ZNF143 ZNF207 ATF7 EGR2 ZMIZ1-AS1 MBL1P ENSG00000272489 NUTM2E NUTM2B NUTM2B-AS1 PIR60133
GH10H079936 1.3 FANTOM5 Ensembl ENCODE 6 +238.6 238603 3.9 MAX CTBP1 EGR1 POLR2A EED ATF7 ETV6 IKZF2 SMARCE1 NRF1 SFTPD MBL1P ANXA11 SFTPA2 CTSLP6 LINC00857 SFTPD-AS1 NUTM2B
GH10H079482 0.7 ENCODE 6.8 -216.0 -215992 2.4 PKNOX1 ZSCAN4 KLF17 ZIC2 ZFHX2 GATA3 POLR2A RCOR1 EGR2 GFI1B ENSG00000224886 ENSG00000235426 ENSG00000235705 NUTM2B TPRX1P1 LOC105378383
GH10H079260 1.1 Ensembl ENCODE dbSUPER 4.2 -438.4 -438417 1.7 TFAP4 MAZ ESRRA ZNF398 THRB POLR2A KLF9 RCOR1 ZNF600 RXRB NUTM2B GC10P079375 PPIF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUTM2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for NUTM2B Gene

Genomic Locations for NUTM2B Gene
chr10:79,699,700-79,715,486
(GRCh38/hg38)
Size:
15,787 bases
Orientation:
Plus strand
chr10:81,462,983-81,474,437
(GRCh37/hg19)

Genomic View for NUTM2B Gene

Genes around NUTM2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTM2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTM2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM2B Gene

Proteins for NUTM2B Gene

  • Protein details for NUTM2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNL0-NTM2B_HUMAN
    Recommended name:
    NUT family member 2B
    Protein Accession:
    A6NNL0
    Secondary Accessions:
    • A6NM73

    Protein attributes for NUTM2B Gene

    Size:
    878 amino acids
    Molecular mass:
    93984 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAQ08562.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ08563.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUTM2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUTM2B Gene

Post-translational modifications for NUTM2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUTM2B Gene

No data available for DME Specific Peptides for NUTM2B Gene

Domains & Families for NUTM2B Gene

Gene Families for NUTM2B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for NUTM2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUTM2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NNL0

UniProtKB/Swiss-Prot:

NTM2B_HUMAN :
  • Belongs to the NUT family.
Family:
  • Belongs to the NUT family.
genes like me logo Genes that share domains with NUTM2B: view

Function for NUTM2B Gene

Animal Model Products

miRNA for NUTM2B Gene

miRTarBase miRNAs that target NUTM2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTM2B Gene

Localization for NUTM2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTM2B gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NUTM2B Gene

Pathways & Interactions for NUTM2B Gene

SuperPathways for NUTM2B Gene

No Data Available

Interacting Proteins for NUTM2B Gene

Selected Interacting proteins: A6NNL0-NTM2B_HUMAN for NUTM2B Gene via IID

Symbol External ID(s) Details
ATXN1

Gene Ontology (GO) - Biological Process for NUTM2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUTM2B Gene

Drugs & Compounds for NUTM2B Gene

No Compound Related Data Available

Transcripts for NUTM2B Gene

mRNA/cDNA for NUTM2B Gene

(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM2B Gene

No ASD Table

Relevant External Links for NUTM2B Gene

GeneLoc Exon Structure for
NUTM2B
ECgene alternative splicing isoforms for
NUTM2B

Expression for NUTM2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUTM2B Gene

NURSA nuclear receptor signaling pathways regulating expression of NUTM2B Gene:

NUTM2B
genes like me logo Genes that share expression patterns with NUTM2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTM2B Gene

Orthologs for NUTM2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC738010 33
  • 98.79 (n)
-- 34
  • 98 (a)
ManyToMany
-- 34
  • 97 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia NUTM2D 33
  • 70.33 (n)
-- 34
  • 46 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NUTM2G 33
  • 67.74 (n)
-- 34
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm806 33 34
  • 58.5 (n)
Nutm2 16
rat
(Rattus norvegicus)
Mammalia Nutm2f 33
  • 58.45 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
OneToMany
Species where no ortholog for NUTM2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUTM2B Gene

ENSEMBL:
Gene Tree for NUTM2B (if available)
TreeFam:
Gene Tree for NUTM2B (if available)

Paralogs for NUTM2B Gene

Paralogs for NUTM2B Gene

(7) SIMAP similar genes for NUTM2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUTM2B: view

Variants for NUTM2B Gene

Sequence variations from dbSNP and Humsavar for NUTM2B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000713405 -- 79,709,491(+) CTTCT(G/T)CCATA intron-variant
rs1002415764 -- 79,704,928(+) GATGG(C/T)TCTCT intron-variant
rs1006861341 -- 79,707,586(+) TGTGG(C/T)TTCAT intron-variant
rs1008513746 -- 79,701,433(+) AACTC(A/C)CTGAC intron-variant, upstream-variant-2KB
rs1009235261 -- 79,703,720(+) TGGAA(A/G)GGAAA intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NUTM2B Gene

Variant ID Type Subtype PubMed ID
nsv950982 CNV deletion 24416366
nsv948085 CNV duplication 23825009
nsv8697 CNV loss 18304495
nsv436110 CNV deletion 17901297
nsv1147914 CNV duplication 26484159
nsv1141879 OTHER inversion 24896259
nsv1110179 CNV duplication 24896259
esv3623921 CNV loss 21293372
esv3546549 CNV deletion 23714750
esv24649 CNV gain+loss 19812545
esv1005705 CNV gain 20482838

Variation tolerance for NUTM2B Gene

Gene Damage Index Score: 4.28; 62.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUTM2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTM2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTM2B Gene

Disorders for NUTM2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUTM2B Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
kidney clear cell sarcoma
  • childhood kidney clear cell sarcoma
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUTM2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUTM2B
genes like me logo Genes that share disorders with NUTM2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTM2B Gene

Publications for NUTM2B Gene

  1. The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney. (PMID: 26542179) Gooskens SL … O'Sullivan MJ (Genes, chromosomes & cancer 2016) 3 60
  2. Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney. (PMID: 26945340) Kao YC … Antonescu CR (The American journal of surgical pathology 2016) 3 60
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J … Zoghbi HY (Cell 2006) 3 60
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 60

Products for NUTM2B Gene

Sources for NUTM2B Gene

Content
Loading form....