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Aliases for NUTM2A Gene

Aliases for NUTM2A Gene

  • NUT Family Member 2A 2 3 5
  • Family With Sequence Similarity 22, Member A 2 3
  • FAM22A 3 4
  • Protein FAM22A 3
  • KIAA2020 4

External Ids for NUTM2A Gene

Previous HGNC Symbols for NUTM2A Gene

  • FAM22A

Previous GeneCards Identifiers for NUTM2A Gene

  • GC10P088985

Summaries for NUTM2A Gene

GeneCards Summary for NUTM2A Gene

NUTM2A (NUT Family Member 2A) is a Protein Coding gene. Diseases associated with NUTM2A include Endometrial Stromal Sarcoma and Endometrial Stromal Nodule. An important paralog of this gene is NUTM2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTM2A Gene

Genomics for NUTM2A Gene

Regulatory Elements for NUTM2A Gene

Enhancers for NUTM2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NUTM2A on UCSC Golden Path with GeneCards custom track

Genomic Location for NUTM2A Gene

Chromosome:
10
Start:
87,223,041 bp from pter
End:
87,236,908 bp from pter
Size:
13,868 bases
Orientation:
Plus strand

Genomic View for NUTM2A Gene

Genes around NUTM2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTM2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTM2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM2A Gene

Proteins for NUTM2A Gene

  • Protein details for NUTM2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVF1-NTM2A_HUMAN
    Recommended name:
    NUT family member 2A
    Protein Accession:
    Q8IVF1
    Secondary Accessions:
    • A6NMX5
    • C9JDI1
    • Q5VZW1

    Protein attributes for NUTM2A Gene

    Size:
    878 amino acids
    Molecular mass:
    93890 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC23116.1; Type=Frameshift; Positions=83; Evidence={ECO:0000305}; Sequence=CAH72466.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUTM2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUTM2A Gene

Post-translational modifications for NUTM2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUTM2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUTM2A Gene

Domains & Families for NUTM2A Gene

Protein Domains for NUTM2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUTM2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVF1

UniProtKB/Swiss-Prot:

NTM2A_HUMAN :
  • Belongs to the NUT family.
Family:
  • Belongs to the NUT family.
genes like me logo Genes that share domains with NUTM2A: view

No data available for Gene Families for NUTM2A Gene

Function for NUTM2A Gene

Animal Model Products

CRISPR Products

miRNA for NUTM2A Gene

miRTarBase miRNAs that target NUTM2A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTM2A Gene

Localization for NUTM2A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NUTM2A Gene

Pathways & Interactions for NUTM2A Gene

SuperPathways for NUTM2A Gene

No Data Available

Interacting Proteins for NUTM2A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371126%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000371126 for NUTM2A Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for NUTM2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NUTM2A Gene

Drugs & Compounds for NUTM2A Gene

No Compound Related Data Available

Transcripts for NUTM2A Gene

mRNA/cDNA for NUTM2A Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUTM2A Gene

NUT family member 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM2A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:

Relevant External Links for NUTM2A Gene

GeneLoc Exon Structure for
NUTM2A
ECgene alternative splicing isoforms for
NUTM2A

Expression for NUTM2A Gene

mRNA expression in normal human tissues for NUTM2A Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NUTM2A Gene



NURSA nuclear receptor signaling pathways regulating expression of NUTM2A Gene:

NUTM2A

SOURCE GeneReport for Unigene cluster for NUTM2A Gene:

Hs.710565
genes like me logo Genes that share expression patterns with NUTM2A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NUTM2A Gene

Orthologs for NUTM2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUTM2D 34
  • 70.57 (n)
  • 55.49 (a)
-- 35
  • 46 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NUTM2G 34
  • 67.85 (n)
  • 53.54 (a)
-- 35
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm806 34
  • 58.11 (n)
  • 41.65 (a)
Gm806 35
  • 39 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC738010 34
  • 98.82 (n)
  • 97.49 (a)
rat
(Rattus norvegicus)
Mammalia Nutm2f 34
  • 58.32 (n)
  • 42.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
Species where no ortholog for NUTM2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUTM2A Gene

ENSEMBL:
Gene Tree for NUTM2A (if available)
TreeFam:
Gene Tree for NUTM2A (if available)

Paralogs for NUTM2A Gene

Paralogs for NUTM2A Gene

(7) SIMAP similar genes for NUTM2A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for NUTM2A Gene

genes like me logo Genes that share paralogs with NUTM2A: view

Variants for NUTM2A Gene

Sequence variations from dbSNP and Humsavar for NUTM2A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3128226 -- 87,228,974(+) GTCCT(C/G/T)GGGGC intron-variant
rs3128238 -- 87,223,295(-) CAATT(C/T)GAGGA intron-variant, utr-variant-5-prime
rs3129338 -- 87,233,094(+) TTCCA(A/T)GGATT intron-variant
rs3129531 -- 87,226,154(+) TATTG(C/T)GGAAA reference, synonymous-codon
rs3897219 -- 87,232,884(+) AAGAG(A/G)GCGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NUTM2A Gene

Variant ID Type Subtype PubMed ID
dgv1281n54 CNV loss 21841781
dgv1282n54 CNV loss 21841781
dgv949n100 CNV gain 25217958
esv1011149 CNV gain 20482838
esv2759774 CNV gain+loss 17122850
esv2764246 CNV gain+loss 21179565
esv27973 CNV gain+loss 19812545
esv3577594 CNV gain 25503493
esv3624105 CNV loss 21293372
nsv1040871 CNV gain 25217958
nsv1128645 CNV duplication 24896259
nsv1139532 CNV duplication 24896259
nsv1141879 OTHER inversion 24896259
nsv1150601 CNV duplication 26484159
nsv428236 CNV loss 18775914
nsv482147 CNV gain 20164927
nsv498736 CNV loss 21111241
nsv551603 CNV loss 21841781
nsv551812 CNV gain 21841781
nsv7483 CNV deletion 18451855
nsv8703 CNV loss 18304495
nsv8715 CNV gain+loss 18304495
nsv948120 CNV duplication 23825009
nsv950986 CNV deletion 24416366

Variation tolerance for NUTM2A Gene

Gene Damage Index Score: 6.86; 79.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUTM2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTM2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTM2A Gene

Disorders for NUTM2A Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUTM2A Gene - From: Orphanet and DISEASES

Disorder Aliases PubMed IDs
endometrial stromal sarcoma
  • endometrial stromal sarcoma, high grade
endometrial stromal nodule
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NUTM2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUTM2A
genes like me logo Genes that share disorders with NUTM2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTM2A Gene

Publications for NUTM2A Gene

  1. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for NUTM2A Gene

Sources for NUTM2A Gene

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