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NUTM2A Gene

protein-coding   GIFtS: 27
GCID: GC10P088985

NUT Family Member 2A

(Previous names: family with sequence similarity 22, member A)
(Previous symbol: FAM22A)
  Search for NUTM2A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NUT Family Member 2A1 2
FAM22A1 2 3
Family With Sequence Similarity 22, Member A1 2
Protein FAM22A2
KIAA20203

External Ids:    HGNC: 234381   Entrez Gene: 7281182   Ensembl: ENSG000001849237   UniProtKB: Q8IVF13   

Export aliases for NUTM2A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUTM2A Gene:
NUTM2A (NUT family member 2A) is a protein-coding gene. An important paralog of this gene is NUTM1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NUTM2A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NUTM2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUTM2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.2   Ensembl cytogenetic band:  10q23.2   HGNC cytogenetic band: 10q23.2

NUTM2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUTM2A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P088985:  view genomic region     (about GC identifiers)

Start:
88,985,205 bp from pter      End:
88,996,665 bp from pter
Size:
11,461 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NTM2A_HUMAN, Q8IVF1 (See protein sequence)
Recommended Name: NUT family member 2A  
Size: 878 amino acids; 93890 Da
Sequence caution: Sequence=BAC23116.1; Type=Frameshift; Positions=83; Sequence=CAH72466.1; Type=Erroneous gene
model prediction;
Secondary accessions: A6NMX5 C9JDI1 Q5VZW1
Alternative splicing: 2 isoforms:  Q8IVF1-1   Q8IVF1-2   

Explore the universe of human proteins at neXtProt for NUTM2A: NX_Q8IVF1

Explore proteomics data for NUTM2A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NUTM2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001092808.1  
    ENSEMBL proteins: 
     ENSP00000371126   ENSP00000371107  

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR024309 NUT_N
     IPR024310 NUT/FAM22
     IPR024313 NUT_C

    Graphical View of Domain Structure for InterPro Entry Q8IVF1

    ProtoNet protein and cluster: Q8IVF1

    UniProtKB/Swiss-Prot: NTM2A_HUMAN, Q8IVF1
    Similarity: Belongs to the NUT family


    NUTM2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUTM2A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUTM2A
    Interactions:

        Search GeneGlobe Interaction Network for NUTM2A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUTM2A (NTM2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUTM2A gene: 
    NM_001099338.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381707(uc001kek.3) ENST00000381689
    miRNA
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    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NUTM2A    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
    SP1:                                -           -                           
    SP2:                                            -                           
    SP3:                                            -                 -         
    SP4:                                -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for NUTM2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUTM2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NUTM2A Expression
    About this image

    NUTM2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUTM2A Protein Expression
        Custom PCR Arrays for NUTM2A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUTM2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NUTM2A gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm8061 predicted gene 806 58.11(n)
    41.65(a)
      328250  NM_001033400.2  NP_001028572.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    GL343220.1(852503-857458)


    ENSEMBL Gene Tree for NUTM2A (if available)
    TreeFam Gene Tree for NUTM2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUTM2A gene
    NUTM2B1 2  NUTM12  NUTM2D2  NUTM2G2  NUTM2F2  NUTM2E2  
    7 SIMAP similar genes for NUTM2A using alignment to 1 protein entry:     NTM2A_HUMAN:
    NUTM2D    NUTM2B    NUTM2E    FAM22F    NUTM2F    NUTM2G
    NUTM1

    NUTM2A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NUTM2A
    PGOHUM00000236269


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUTM2A (see all 80)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs566778891,2
    C--88983596(+) CTCTA-/CTGGGT 1 -- us2k10--------
    rs741504441,2
    C,F--88983629(+) CAGGGC/GATCCA 1 -- us2k11Minor allele frequency- G:0.00WA 2
    rs24787011,2
    C,F,A,H--88983638(+) CAAGCC/ACTGAG 1 -- us2k17Minor allele frequency- A:0.34NS EA NA WA 418
    rs1417607181,2
    --88983659(+) TCAGCC/TGTCAG 1 -- us2k10--------
    rs24787021,2
    C,H--88983725(+) AGCCAA/CCACCT 1 -- us2k14Minor allele frequency- C:0.00EA NS NA 182
    rs3753986081,2
    C--88983941(+) ACTGAC/TTGACA 1 -- us2k10--------
    rs2004256921,2
    C--88988051(+) ACCGCG/AAACCC 2 /A syn11Minor allele frequency- A:0.00EU 527
    rs2001685401,2
    C,F--88988115(+) GCCCAG/ACACAC 2 /T /A mis11Minor allele frequency- A:0.18EU 437
    rs2004253001,2
    F--88988232(+) GGGCCG/AGGGCT 2 /R /G mis11Minor allele frequency- A:0.00EU 593
    rs2013946281,2
    F--88988307(+) TGGTCC/TTAACT 2 L syn11Minor allele frequency- T:0.01EU 501

    HapMap Linkage Disequilibrium report for NUTM2A (88985205 - 88996665 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NUTM2A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUTM2A
    DNA2.0 Custom Variant and Variant Library Synthesis for NUTM2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUTM2A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NUTM2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (Nature 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 728118 HGNC: 23438 Ensembl:ENSG00000184923 euGenes: HUgn728118 ECgene: NUTM2A
    H-InvDB: NUTM2A

    (According to HUGE)
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    HUGE: KIAA2020

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUTM2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUTM2A gene:
    Search GeneIP for patents involving NUTM2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Browse SwitchGear Promoter luciferase reporter plasmids for NUTM2A
     Search ThermoFisher Antibodies for NUTM2A
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NUTM2A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUTM2A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUTM2A
     LSBio Antibodies in human, mouse, rat for NUTM2A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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