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Aliases for NUTM1 Gene

Aliases for NUTM1 Gene

  • NUT Midline Carcinoma, Family Member 1 2 3
  • Nuclear Protein In Testis 2 3 4
  • C15orf55 3 4
  • NUT 3 4
  • Chromosome 15 Open Reading Frame 55 2
  • NUT Family Member 1 3
  • FAM22H 3

External Ids for NUTM1 Gene

Previous Symbols for NUTM1 Gene

  • C15orf55

Summaries for NUTM1 Gene

GeneCards Summary for NUTM1 Gene

NUTM1 (NUT Midline Carcinoma, Family Member 1) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. An important paralog of this gene is NUTM2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTM1 Gene

Genomics for NUTM1 Gene

Genomic Location for NUTM1 Gene

Start:
34,343,315 bp from pter
End:
34,357,737 bp from pter
Size:
14,423 bases
Orientation:
Plus strand

Genomic View for NUTM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM1 Gene

No data available for Regulatory Elements for NUTM1 Gene

Proteins for NUTM1 Gene

  • Protein details for NUTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y26-NUTM1_HUMAN
    Recommended name:
    NUT family member 1
    Protein Accession:
    Q86Y26
    Secondary Accessions:
    • B4DZ00
    • B7Z7Y4
    • E7EVE8
    • F5H4I6
    • Q86YS8
    • Q8N7F2
    • Q9NTB3

    Protein attributes for NUTM1 Gene

    Size:
    1132 amino acids
    Molecular mass:
    120314 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO22237.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUTM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUTM1 Gene

Proteomics data for NUTM1 Gene at MOPED

Post-translational modifications for NUTM1 Gene

  • Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUTM1 Gene

No data available for DME Specific Peptides for NUTM1 Gene

Domains for NUTM1 Gene

Protein Domains for NUTM1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NUTM1_HUMAN
Family:
  • Belongs to the NUT family.:
    • Q86Y26
genes like me logo Genes that share domains with NUTM1: view

No data available for Gene Families for NUTM1 Gene

Function for NUTM1 Gene

Gene Ontology (GO) - Molecular Function for NUTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NUTM1: view

Phenotypes for NUTM1 Gene

genes like me logo Genes that share phenotypes with NUTM1: view

miRNA for NUTM1 Gene

miRTarBase miRNAs that target NUTM1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUTM1 Gene

Localization for NUTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTM1 Gene

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm.

Gene Ontology (GO) - Cellular Components for NUTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NUTM1: view

Pathways for NUTM1 Gene

genes like me logo Genes that share pathways with NUTM1: view

Pathways by source for NUTM1 Gene

1 Cell Signaling Technology pathway for NUTM1 Gene

Gene Ontology (GO) - Biological Process for NUTM1 Gene

None

Transcripts for NUTM1 Gene

Unigene Clusters for NUTM1 Gene

NUT midline carcinoma, family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM1 Gene

No ASD Table

Relevant External Links for NUTM1 Gene

GeneLoc Exon Structure for
NUTM1
ECgene alternative splicing isoforms for
NUTM1

Expression for NUTM1 Gene

mRNA expression in normal human tissues for NUTM1 Gene

mRNA differential expression in normal tissues according to GTEx for NUTM1 Gene

This gene is overexpressed in Testis (48.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NUTM1 Gene

SOURCE GeneReport for Unigene cluster for NUTM1 Gene Hs.525769

mRNA Expression by UniProt/SwissProt for NUTM1 Gene

Q86Y26-NUTM1_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expressions with NUTM1: view

Orthologs for NUTM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf55 36
  • 98.97 (n)
  • 97.93 (a)
NUTM1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUTM1 36
  • 80.07 (n)
  • 68.93 (a)
NUTM1 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C30H15orf55 36
  • 76.52 (n)
  • 63.88 (a)
NUTM1 37
  • 44 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC125332 16
Nutm1 36
  • 76.58 (n)
  • 66.31 (a)
Nutm1 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nutm1 36
  • 77.42 (n)
  • 66.94 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 54 (a)
OneToMany
Species with no ortholog for NUTM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUTM1 Gene

ENSEMBL:
Gene Tree for NUTM1 (if available)
TreeFam:
Gene Tree for NUTM1 (if available)

Paralogs for NUTM1 Gene

Paralogs for NUTM1 Gene

Selected SIMAP similar genes for NUTM1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NUTM1: view

Variants for NUTM1 Gene

Sequence variations from dbSNP and Humsavar for NUTM1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs182975 -- 34,351,308(-) agcct(C/T)tagag intron-variant
rs189420 -- 34,353,221(+) GCAGG(A/G)TCTCA intron-variant
rs347794 -- 34,351,945(-) TGATC(C/T)GCCTG intron-variant
rs347795 -- 34,351,893(-) ACGCC(C/T)AGCCT intron-variant
rs347796 -- 34,350,902(-) ACAAG(C/T)CTCTC intron-variant

Relevant External Links for NUTM1 Gene

HapMap Linkage Disequilibrium report
NUTM1

No data available for Structural Variations from Database of Genomic Variants (DGV) for NUTM1 Gene

Disorders for NUTM1 Gene

UniProtKB/Swiss-Prot

NUTM1_HUMAN
  • Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein. {ECO:0000269 PubMed:12543779}.
  • Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein. {ECO:0000269 PubMed:12543779}.

No disorders were found for NUTM1 Gene.

Publications for NUTM1 Gene

  1. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. (PMID: 12543779) French C.A. … Fletcher J.A. (Cancer Res. 2003) 2 3 4
  2. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. (PMID: 17934517) French C.A. … Aster J.C. (Oncogene 2008) 3 4
  3. NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract. (PMID: 18391746) Stelow E.B. … French C.A. (Am. J. Surg. Pathol. 2008) 3
  4. Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). (PMID: 19550370) Stelow E.B. … French C.A. (Adv Anat Pathol 2009) 3
  5. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. (PMID: 20676058) Reynoird N. … Khochbin S. (EMBO J. 2010) 3

Products for NUTM1 Gene

Sources for NUTM1 Gene

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