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Aliases for NUTM1 Gene

Aliases for NUTM1 Gene

  • NUT Midline Carcinoma Family Member 1 2 3
  • Nuclear Protein In Testis 2 3 4
  • NUT Midline Carcinoma, Family Member 1 3 5
  • C15orf55 3 4
  • NUT 3 4
  • Chromosome 15 Open Reading Frame 55 2
  • FAM22H 3

External Ids for NUTM1 Gene

Previous HGNC Symbols for NUTM1 Gene

  • C15orf55

Previous GeneCards Identifiers for NUTM1 Gene

  • GC15P034636

Summaries for NUTM1 Gene

GeneCards Summary for NUTM1 Gene

NUTM1 (NUT Midline Carcinoma Family Member 1) is a Protein Coding gene. Diseases associated with NUTM1 include Nut Midline Carcinoma and Nut Allergy. Among its related pathways are Chromatin Regulation / Acetylation. An important paralog of this gene is NUTM2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTM1 Gene

Genomics for NUTM1 Gene

Regulatory Elements for NUTM1 Gene

Enhancers for NUTM1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUTM1 on UCSC Golden Path with GeneCards custom track

Promoters for NUTM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUTM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUTM1 Gene

34,343,251 bp from pter
34,357,737 bp from pter
14,487 bases
Plus strand

Genomic View for NUTM1 Gene

Genes around NUTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM1 Gene

Proteins for NUTM1 Gene

  • Protein details for NUTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NUT family member 1
    Protein Accession:
    Secondary Accessions:
    • B4DZ00
    • B7Z7Y4
    • E7EVE8
    • F5H4I6
    • Q86YS8
    • Q8N7F2
    • Q9NTB3

    Protein attributes for NUTM1 Gene

    1132 amino acids
    Molecular mass:
    120314 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO22237.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUTM1 Gene


neXtProt entry for NUTM1 Gene

Proteomics data for NUTM1 Gene at MOPED

Post-translational modifications for NUTM1 Gene

  • Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUTM1 Gene

No data available for DME Specific Peptides for NUTM1 Gene

Domains & Families for NUTM1 Gene

Protein Domains for NUTM1 Gene


Suggested Antigen Peptide Sequences for NUTM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NUT family.
  • Belongs to the NUT family.
genes like me logo Genes that share domains with NUTM1: view

No data available for Gene Families for NUTM1 Gene

Function for NUTM1 Gene

genes like me logo Genes that share phenotypes with NUTM1: view

Animal Model Products

CRISPR Products

miRNA for NUTM1 Gene

miRTarBase miRNAs that target NUTM1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTM1 Gene

Localization for NUTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTM1 Gene

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NUTM1 Gene

Pathways & Interactions for NUTM1 Gene

genes like me logo Genes that share pathways with NUTM1: view

Pathways by source for NUTM1 Gene

1 Cell Signaling Technology pathway for NUTM1 Gene

Gene Ontology (GO) - Biological Process for NUTM1 Gene


No data available for SIGNOR curated interactions for NUTM1 Gene

Drugs & Compounds for NUTM1 Gene

No Compound Related Data Available

Transcripts for NUTM1 Gene

Unigene Clusters for NUTM1 Gene

NUT midline carcinoma, family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM1 Gene

No ASD Table

Relevant External Links for NUTM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUTM1 Gene

mRNA expression in normal human tissues for NUTM1 Gene

mRNA differential expression in normal tissues according to GTEx for NUTM1 Gene

This gene is overexpressed in Testis (x48.7).

Protein differential expression in normal tissues from HIPED for NUTM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.9) and Heart (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUTM1 Gene

SOURCE GeneReport for Unigene cluster for NUTM1 Gene Hs.525769

mRNA Expression by UniProt/SwissProt for NUTM1 Gene

Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expression patterns with NUTM1: view

Protein tissue co-expression partners for NUTM1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NUTM1 Gene

Orthologs for NUTM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUTM1 35
  • 80.07 (n)
  • 68.93 (a)
NUTM1 36
  • 66 (a)
(Canis familiaris)
Mammalia C30H15orf55 35
  • 76.52 (n)
  • 63.88 (a)
NUTM1 36
  • 44 (a)
(Mus musculus)
Mammalia Nutm1 35
  • 76.58 (n)
  • 66.31 (a)
Nutm1 16
Nutm1 36
  • 65 (a)
(Pan troglodytes)
Mammalia C15H15orf55 35
  • 98.97 (n)
  • 97.93 (a)
NUTM1 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Nutm1 35
  • 77.42 (n)
  • 66.94 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
Species with no ortholog for NUTM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUTM1 Gene

Gene Tree for NUTM1 (if available)
Gene Tree for NUTM1 (if available)

Paralogs for NUTM1 Gene

Paralogs for NUTM1 Gene

(7) SIMAP similar genes for NUTM1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NUTM1: view

Variants for NUTM1 Gene

Sequence variations from dbSNP and Humsavar for NUTM1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs374230 - 34,348,017(-) GAGAC(A/G)GGGCG reference, missense
rs16959028 - 34,356,434(+) GGATA(C/T)GGAGA reference, missense
rs17236868 - 34,356,446(+) CAGTG(A/T)GATTC reference, missense
rs2279683 - 34,357,010(+) AAGCA(A/C)TTTGC reference, missense
rs2279684 - 34,357,046(+) AGTTC(C/G/T)GAGAG reference, missense

Variation tolerance for NUTM1 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.00; 87.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NUTM1 Gene

Disorders for NUTM1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NUTM1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
nut allergy
  • allergy to nuts
extragonadal seminoma
  • primary extragonadal seminoma
- elite association - COSMIC cancer census association via MalaCards
Search NUTM1 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein. {ECO:0000269 PubMed:12543779}.
  • Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein. {ECO:0000269 PubMed:12543779}.

Relevant External Links for NUTM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NUTM1: view

No data available for Genatlas for NUTM1 Gene

Publications for NUTM1 Gene

  1. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. (PMID: 12543779) French C.A. … Fletcher J.A. (Cancer Res. 2003) 2 3 4 67
  2. Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation. (PMID: 25512383) Wang R. … You J. (J. Biol. Chem. 2015) 3
  3. NUT protein immunoreactivity in ovarian germ cell tumours. (PMID: 25551299) Iacobelli J.F. … Stewart C.J. (Pathology 2015) 3
  4. Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. (PMID: 26001144) Sholl L.M. … Lathan C. (J Thorac Oncol 2015) 3
  5. The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. (PMID: 26220994) Alekseyenko A.A. … French C.A. (Genes Dev. 2015) 3

Products for NUTM1 Gene

Sources for NUTM1 Gene