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Aliases for NUTM1 Gene

Aliases for NUTM1 Gene

  • NUT Midline Carcinoma Family Member 1 2 3 5
  • Nuclear Protein In Testis 2 3 4
  • C15orf55 3 4
  • NUT 3 4
  • Chromosome 15 Open Reading Frame 55 2
  • NUT Family Member 1 3
  • FAM22H 3

External Ids for NUTM1 Gene

Previous HGNC Symbols for NUTM1 Gene

  • C15orf55

Previous GeneCards Identifiers for NUTM1 Gene

  • GC15P034636

Summaries for NUTM1 Gene

GeneCards Summary for NUTM1 Gene

NUTM1 (NUT Midline Carcinoma Family Member 1) is a Protein Coding gene. Diseases associated with NUTM1 include Nut Midline Carcinoma and Extragonadal Nonseminomatous Germ Cell Tumor. Among its related pathways are Chromatin Regulation / Acetylation. An important paralog of this gene is NUTM2D.

Additional gene information for NUTM1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTM1 Gene

Genomics for NUTM1 Gene

Regulatory Elements for NUTM1 Gene

Enhancers for NUTM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H034513 1.3 Ensembl ENCODE 30.1 +171.5 171450 2 PKNOX1 ARNT ARID4B FEZF1 DMAP1 YBX1 ZNF2 ZNF766 ZNF302 SP3 AQR HNRNPLP2 GOLGA8A ENSG00000259287 LOC101929988 NUTM1 LINC02252 ENSG00000259468 FSCN1P1 ENSG00000259336
GH15H033984 1.2 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -357.8 -357809 1 JUND NUTM1 CHRM5 AVEN ENSG00000259505 ENSG00000278472
GH15H034223 1.1 ENCODE 21.7 -118.3 -118347 2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 NOP10 AQR HNRNPLP2 NUTM1 SLC12A6 ENSG00000259287 ENSG00000259336 KATNBL1 EMC4
GH15H034968 1.1 ENCODE 21.7 +626.2 626217 1 HDGF FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 AQR HNRNPLP2 NUTM1 ENSG00000259336 GOLGA8A GOLGA8B ENSG00000259665 ZNF770 GC15P034944
GH15H034238 1 Ensembl ENCODE 11.5 -103.1 -103051 4 CTCF JUN BATF RAD21 FOSL1 GATA3 ZNF316 POLR2A SMC3 ZNF143 NOP10 KATNBL1 SLC12A6 NUTM1 EMC4 ENSG00000259468
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUTM1 on UCSC Golden Path with GeneCards custom track

Promoters for NUTM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000074790 -451 1201 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for NUTM1 Gene

Chromosome:
15
Start:
34,343,251 bp from pter
End:
34,357,737 bp from pter
Size:
14,487 bases
Orientation:
Plus strand

Genomic View for NUTM1 Gene

Genes around NUTM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTM1 Gene

Proteins for NUTM1 Gene

  • Protein details for NUTM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y26-NUTM1_HUMAN
    Recommended name:
    NUT family member 1
    Protein Accession:
    Q86Y26
    Secondary Accessions:
    • B4DZ00
    • B7Z7Y4
    • E7EVE8
    • F5H4I6
    • Q86YS8
    • Q8N7F2
    • Q9NTB3

    Protein attributes for NUTM1 Gene

    Size:
    1132 amino acids
    Molecular mass:
    120314 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO22237.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUTM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUTM1 Gene

Post-translational modifications for NUTM1 Gene

  • Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUTM1 Gene

No data available for DME Specific Peptides for NUTM1 Gene

Domains & Families for NUTM1 Gene

Gene Families for NUTM1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for NUTM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUTM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86Y26

UniProtKB/Swiss-Prot:

NUTM1_HUMAN :
  • Belongs to the NUT family.
Family:
  • Belongs to the NUT family.
genes like me logo Genes that share domains with NUTM1: view

Function for NUTM1 Gene

Phenotypes From GWAS Catalog for NUTM1 Gene

Gene Ontology (GO) - Molecular Function for NUTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NUTM1: view
genes like me logo Genes that share phenotypes with NUTM1: view

Animal Model Products

CRISPR Products

miRNA for NUTM1 Gene

miRTarBase miRNAs that target NUTM1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTM1 Gene

Localization for NUTM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTM1 Gene

Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTM1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NUTM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NUTM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUTM1 Gene

Pathways & Interactions for NUTM1 Gene

genes like me logo Genes that share pathways with NUTM1: view

Pathways by source for NUTM1 Gene

1 Cell Signaling Technology pathway for NUTM1 Gene

Gene Ontology (GO) - Biological Process for NUTM1 Gene

None

No data available for SIGNOR curated interactions for NUTM1 Gene

Drugs & Compounds for NUTM1 Gene

No Compound Related Data Available

Transcripts for NUTM1 Gene

Unigene Clusters for NUTM1 Gene

NUT midline carcinoma, family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUTM1 Gene

No ASD Table

Relevant External Links for NUTM1 Gene

GeneLoc Exon Structure for
NUTM1
ECgene alternative splicing isoforms for
NUTM1

Expression for NUTM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUTM1 Gene

mRNA differential expression in normal tissues according to GTEx for NUTM1 Gene

This gene is overexpressed in Testis (x48.7).

Protein differential expression in normal tissues from HIPED for NUTM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.9) and Heart (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUTM1 Gene



Protein tissue co-expression partners for NUTM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUTM1 Gene:

NUTM1

SOURCE GeneReport for Unigene cluster for NUTM1 Gene:

Hs.525769

mRNA Expression by UniProt/SwissProt for NUTM1 Gene:

Q86Y26-NUTM1_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expression patterns with NUTM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTM1 Gene

Orthologs for NUTM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUTM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf55 33
  • 98.97 (n)
NUTM1 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUTM1 33 34
  • 80.07 (n)
rat
(Rattus norvegicus)
Mammalia Nutm1 33
  • 77.42 (n)
mouse
(Mus musculus)
Mammalia Nutm1 33 16 34
  • 76.58 (n)
dog
(Canis familiaris)
Mammalia C30H15orf55 33
  • 76.52 (n)
NUTM1 34
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
OneToMany
Species where no ortholog for NUTM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUTM1 Gene

ENSEMBL:
Gene Tree for NUTM1 (if available)
TreeFam:
Gene Tree for NUTM1 (if available)

Paralogs for NUTM1 Gene

Paralogs for NUTM1 Gene

(7) SIMAP similar genes for NUTM1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NUTM1: view

Variants for NUTM1 Gene

Sequence variations from dbSNP and Humsavar for NUTM1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs121908092 Pathogenic 34,342,063(-) CTGCT(C/T)GGTTC upstream-variant-2KB, reference, missense
rs115413508 Likely benign 34,341,839(+) TCAAT(C/T)GCCAC upstream-variant-2KB, utr-variant-3-prime
rs146261631 Likely benign 34,343,040(+) TCGAT(C/G)TCCCT upstream-variant-2KB, reference, missense
rs2169480 Likely benign 34,343,168(+) CCTGC(A/G)TAACC upstream-variant-2KB
rs3063 Likely benign 34,341,832(+) AGCAT(A/G/T)ATCAA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NUTM1 Gene

Variant ID Type Subtype PubMed ID
dgv4456n54 CNV gain 21841781
esv1006076 CNV insertion 20482838
esv2760024 CNV gain+loss 17122850
esv33337 CNV gain+loss 17666407
esv3397576 CNV duplication 20981092
esv3569431 CNV gain 25503493
esv3636114 CNV loss 21293372
nsv1052620 CNV gain 25217958
nsv1485 CNV deletion 18451855
nsv428303 CNV gain 18775914
nsv469547 CNV loss 16826518
nsv471682 CNV gain+loss 15918152
nsv509567 CNV insertion 20534489
nsv513428 CNV insertion 21212237
nsv517751 CNV gain+loss 19592680

Variation tolerance for NUTM1 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.00; 87.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUTM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTM1 Gene

Disorders for NUTM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NUTM1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
extragonadal nonseminomatous germ cell tumor
  • primary malignant extragonadal nonseminoma
extragonadal germ cell cancer
  • extragonadal germ cell malignant tumor
nasal cavity squamous cell carcinoma
  • squamous cell carcinoma of nasal cavity
extragonadal seminoma
  • primary extragonadal seminoma
- elite association - COSMIC cancer census association via MalaCards
Search NUTM1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NUTM1_HUMAN
  • Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein. {ECO:0000269 PubMed:12543779}.
  • Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein. {ECO:0000269 PubMed:12543779}.

Relevant External Links for NUTM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUTM1
genes like me logo Genes that share disorders with NUTM1: view

No data available for Genatlas for NUTM1 Gene

Publications for NUTM1 Gene

  1. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. (PMID: 12543779) French CA … Fletcher JA (Cancer research 2003) 2 3 4 60
  2. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. (PMID: 17934517) French CA … Aster JC (Oncogene 2008) 3 4 60
  3. Complex Chromosomal Rearrangements by Single Catastrophic Pathogenesis in NUT Midline Carcinoma. (PMID: 28203693) Lee JK … Ju YS (Annals of oncology : official journal of the European Society for Medical Oncology 2017) 3 60
  4. The Oncoprotein BRD4-NUT Generates Aberrant Histone Modification Patterns. (PMID: 27698495) Zee BM … Kuroda MI (PloS one 2016) 3 60
  5. The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. (PMID: 26220994) Alekseyenko AA … French CA (Genes & development 2015) 3 60

Products for NUTM1 Gene

Sources for NUTM1 Gene

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