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Aliases for NUTF2 Gene

Aliases for NUTF2 Gene

  • Nuclear Transport Factor 2 2 3 5
  • Placental Protein 15 3 4
  • NTF-2 3 4
  • NTF2 3 4
  • PP15 3 4

External Ids for NUTF2 Gene

Previous GeneCards Identifiers for NUTF2 Gene

  • GC16P058575
  • GC16P068258
  • GC16P067616
  • GC16P067657
  • GC16P066438
  • GC16P067880
  • GC16P053772

Summaries for NUTF2 Gene

Entrez Gene Summary for NUTF2 Gene

  • This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

GeneCards Summary for NUTF2 Gene

NUTF2 (Nuclear Transport Factor 2) is a Protein Coding gene. Diseases associated with NUTF2 include Retinitis Pigmentosa 7 And Digenic. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot for NUTF2 Gene

  • Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Gene Wiki entry for NUTF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTF2 Gene

Genomics for NUTF2 Gene

Regulatory Elements for NUTF2 Gene

Enhancers for NUTF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G067909 1.2 ENCODE dbSUPER 10.8 +63.4 63446 1.1 FOXA2 AGO1 ARID4B YY1 KLF13 SP5 ZHX2 KAT8 NFIL3 SSRP1 NRN1L EDC4 NUTF2 THAP11 DUS2 ACD PARD6A DDX28 TPPP3 PSKH1
GH16G067908 0.8 dbSUPER 10.8 +62.0 62031 0.5 AGO1 ARID4B DMAP1 RAD21 ZNF143 MIXL1 PAF1 PPARG SSRP1 KLF16 NRN1L EDC4 NUTF2 THAP11 DUS2 ACD PARD6A DDX28 PSKH1 CTRL
GH16G067560 1.7 FANTOM5 ENCODE dbSUPER 4.7 -283.6 -283557 5.8 HDGF FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ATP6V0D1 ZDHHC1 ENKD1 ENSG00000261386 ENSG00000259804 SLC7A6OS SLC7A6 NFATC3 DUS2 NUTF2
GH16G067841 1.2 ENCODE 0.7 -1.7 -1743 7.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ZDHHC1 ENKD1 RANBP10 DUS2 SLC7A6OS ENSG00000261386 PRMT7 ENSG00000259804 DPEP2 HSD11B2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUTF2 on UCSC Golden Path with GeneCards custom track

Promoters for NUTF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087184 368 1801 HDGF HNRNPUL1 CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for NUTF2 Gene

Chromosome:
16
Start:
67,846,732 bp from pter
End:
67,872,567 bp from pter
Size:
25,836 bases
Orientation:
Plus strand

Genomic View for NUTF2 Gene

Genes around NUTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTF2 Gene

Proteins for NUTF2 Gene

  • Protein details for NUTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61970-NTF2_HUMAN
    Recommended name:
    Nuclear transport factor 2
    Protein Accession:
    P61970
    Secondary Accessions:
    • B2R4G7
    • P13662
    • Q6IB67

    Protein attributes for NUTF2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Homodimer (PubMed:7744965). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed:10679025). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed:7744965). Interacts with CAPG; mediates its nuclear import (PubMed:18266911).

    Three dimensional structures from OCA and Proteopedia for NUTF2 Gene

neXtProt entry for NUTF2 Gene

Post-translational modifications for NUTF2 Gene

  • Ubiquitination at Lys55
  • Modification sites at PhosphoSitePlus

Other Protein References for NUTF2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NUTF2 (NUTF2)
  • Abcam antibodies for NUTF2
  • Cloud-Clone Corp. Antibodies for NUTF2

No data available for DME Specific Peptides for NUTF2 Gene

Domains & Families for NUTF2 Gene

Protein Domains for NUTF2 Gene

Suggested Antigen Peptide Sequences for NUTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUTF2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NUTF2 Gene

Function for NUTF2 Gene

Molecular function for NUTF2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Gene Ontology (GO) - Molecular Function for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IDA 7744965
GO:0005515 protein binding IPI 7744965
GO:0008320 protein transmembrane transporter activity IDA --
GO:0008536 Ran GTPase binding IPI 18266911
genes like me logo Genes that share ontologies with NUTF2: view
genes like me logo Genes that share phenotypes with NUTF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTF2 Gene

Localization for NUTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTF2 Gene

Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000269 PubMed:10679025}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUTF2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005643 nuclear pore IEA --
genes like me logo Genes that share ontologies with NUTF2: view

Pathways & Interactions for NUTF2 Gene

SuperPathways for NUTF2 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with NUTF2: view

Pathways by source for NUTF2 Gene

1 Cell Signaling Technology pathway for NUTF2 Gene

Gene Ontology (GO) - Biological Process for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 18266911
GO:0006606 protein import into nucleus IDA 7744965
GO:0006611 protein export from nucleus IDA 16449645
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NUTF2: view

No data available for SIGNOR curated interactions for NUTF2 Gene

Drugs & Compounds for NUTF2 Gene

(2) Additional Compounds for NUTF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUTF2: view

Transcripts for NUTF2 Gene

Unigene Clusters for NUTF2 Gene

Nuclear transport factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUTF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - - - -

Relevant External Links for NUTF2 Gene

GeneLoc Exon Structure for
NUTF2
ECgene alternative splicing isoforms for
NUTF2

Expression for NUTF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUTF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUTF2 Gene



Protein tissue co-expression partners for NUTF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUTF2 Gene:

NUTF2

SOURCE GeneReport for Unigene cluster for NUTF2 Gene:

Hs.356630

Evidence on tissue expression from TISSUES for NUTF2 Gene

  • Lung(4.3)
  • Nervous system(3.5)
  • Muscle(2)
genes like me logo Genes that share expression patterns with NUTF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUTF2 Gene

Orthologs for NUTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUTF2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Nutf2-ps1 35
  • 100 (a)
OneToMany
Nutf2 34 35
  • 94.23 (n)
Nutf2-ps2 16
chimpanzee
(Pan troglodytes)
Mammalia NUTF2 34 35
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NUTF2 34 35
  • 95.8 (n)
dog
(Canis familiaris)
Mammalia NUTF2 34 35
  • 95.54 (n)
rat
(Rattus norvegicus)
Mammalia Nutf2 34
  • 93.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUTF2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUTF2 34 35
  • 76.12 (n)
lizard
(Anolis carolinensis)
Reptilia NUTF2 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nutf2 34
  • 81.1 (n)
Str.10710 34
African clawed frog
(Xenopus laevis)
Amphibia nutf2-prov 34
zebrafish
(Danio rerio)
Actinopterygii nutf2 34 35
  • 78.22 (n)
wufb40a01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9725 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007024 34
  • 53.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ntf-2r 34 35
  • 51.82 (n)
Ntf-2 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-4 34 35
  • 54.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR013W 34
  • 51.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13508g 34
  • 48.99 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTF2 34 35 37
  • 48.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NTF2B 34
  • 49.42 (n)
rice
(Oryza sativa)
Liliopsida Os08g0532300 34
  • 51.44 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nxt2 34
  • 54.8 (n)
Species where no ortholog for NUTF2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUTF2 Gene

ENSEMBL:
Gene Tree for NUTF2 (if available)
TreeFam:
Gene Tree for NUTF2 (if available)

Paralogs for NUTF2 Gene

No data available for Paralogs for NUTF2 Gene

Variants for NUTF2 Gene

Sequence variations from dbSNP and Humsavar for NUTF2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000000842 -- 67,853,556(+) TTTCA(C/T)CATAT intron-variant
rs1000082581 -- 67,845,853(+) AAAAA(C/T)AGAAG intron-variant, upstream-variant-2KB
rs1000108866 -- 67,856,514(+) CTTTT(G/T)TTTTC intron-variant
rs1000112117 -- 67,860,436(+) TGCCC(A/G/T)GCTAA intron-variant
rs1000150548 -- 67,863,380(+) ATAAA(-/GCTG)GCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUTF2 Gene

Variant ID Type Subtype PubMed ID
nsv1131269 CNV deletion 24896259
nsv1844 CNV deletion 18451855
nsv478420 CNV novel sequence insertion 20440878
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv977988 CNV duplication 23825009
nsv984342 CNV duplication 23825009

Variation tolerance for NUTF2 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUTF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTF2 Gene

Disorders for NUTF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUTF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 7 and digenic
  • leber congenital amaurosis 18
- elite association - COSMIC cancer census association via MalaCards
Search NUTF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUTF2

Genetic Association Database (GAD)
NUTF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUTF2
genes like me logo Genes that share disorders with NUTF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUTF2 Gene

Publications for NUTF2 Gene

  1. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (PMID: 7744965) Paschal B.M. … Gerace L. (J. Cell Biol. 1995) 2 3 4 22 64
  2. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K. … Gettemans J. (Traffic 2008) 3 4 22 64
  3. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. (PMID: 10679025) Steggerda S.M. … Paschal B.M. (Mol. Biol. Cell 2000) 3 4 22 64
  4. Isolation of cDNA coding for the placental protein 15 (PP15). (PMID: 3380696) Grundmann U. … Kuepper H.A. (Nucleic Acids Res. 1988) 2 3 4 64
  5. Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. (PMID: 19404486) Li B. … Tang S.B. (Mol. Vis. 2009) 3 22 64

Products for NUTF2 Gene

Sources for NUTF2 Gene

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