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Aliases for NUTF2 Gene

Aliases for NUTF2 Gene

  • Nuclear Transport Factor 2 2 3 5
  • Placental Protein 15 3 4
  • NTF-2 3 4
  • NTF2 3 4
  • PP15 3 4

External Ids for NUTF2 Gene

Previous GeneCards Identifiers for NUTF2 Gene

  • GC16P058575
  • GC16P068258
  • GC16P067616
  • GC16P067657
  • GC16P066438
  • GC16P067880
  • GC16P053772

Summaries for NUTF2 Gene

Entrez Gene Summary for NUTF2 Gene

  • This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

GeneCards Summary for NUTF2 Gene

NUTF2 (Nuclear Transport Factor 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot for NUTF2 Gene

  • Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Gene Wiki entry for NUTF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTF2 Gene

Genomics for NUTF2 Gene

Regulatory Elements for NUTF2 Gene

Enhancers for NUTF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F067909 0.2 ENCODE 10.8 +63.4 63446 1.1 TBP ELF3 ARID4B THRB RAD21 YY1 RARA SCRT2 CREM KLF13 NRN1L EDC4 NUTF2 THAP11 DUS2 ACD PARD6A DDX28 TPPP3 PSKH1
GH16F068021 0.5 ENCODE 9.9 +176.4 176373 3.0 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 ZNF263 ZDHHC1 PSKH1 B3GNT9 PRMT7 CENPT NUTF2 FHOD1 DDX28 GC16M068022 PIR37774
GH16F067403 1.1 Ensembl ENCODE 9.9 -441.1 -441126 5.1 PKNOX1 SIN3A ZBTB40 RAD21 ZNF121 SCRT2 RCOR1 FOS ZNF263 ZHX2 LRRC36 HSD11B2 PLEKHG4 NUTF2 LRRC29 TMEM208 ATP6V0D1 DPEP2 SLC7A6 PRMT7
GH16F068710 1.3 Ensembl ENCODE 9.9 +864.7 864669 1.6 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF207 FOS ZFP90 TERF2 NUTF2 CDH1 DUS2 GC16P068716 GC16P068687
GH16F066932 0.2 ENCODE 9.9 -911.4 -911431 5.0 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF302 ZNF143 FOS CES3 CES2 NUTF2 NAE1 ENSG00000265408
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NUTF2 on UCSC Golden Path with GeneCards custom track

Promoters for NUTF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000509055 368 2201 HDGF ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1
ENSR00001802338 1768 201

Genomic Location for NUTF2 Gene

Chromosome:
16
Start:
67,846,732 bp from pter
End:
67,872,567 bp from pter
Size:
25,836 bases
Orientation:
Plus strand

Genomic View for NUTF2 Gene

Genes around NUTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTF2 Gene

Proteins for NUTF2 Gene

  • Protein details for NUTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61970-NTF2_HUMAN
    Recommended name:
    Nuclear transport factor 2
    Protein Accession:
    P61970
    Secondary Accessions:
    • B2R4G7
    • P13662
    • Q6IB67

    Protein attributes for NUTF2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Homodimer (PubMed:7744965). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed:10679025). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed:7744965). Interacts with CAPG; mediates its nuclear import (PubMed:18266911).

    Three dimensional structures from OCA and Proteopedia for NUTF2 Gene

neXtProt entry for NUTF2 Gene

Post-translational modifications for NUTF2 Gene

  • Ubiquitination at Lys 55
  • Modification sites at PhosphoSitePlus

Other Protein References for NUTF2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NUTF2 (NUTF2)
  • Abcam antibodies for NUTF2
  • Cloud-Clone Corp. Antibodies for NUTF2

No data available for DME Specific Peptides for NUTF2 Gene

Domains & Families for NUTF2 Gene

Protein Domains for NUTF2 Gene

Suggested Antigen Peptide Sequences for NUTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61970

UniProtKB/Swiss-Prot:

NTF2_HUMAN :
  • Contains 1 NTF2 domain.
Domain:
  • Contains 1 NTF2 domain.
genes like me logo Genes that share domains with NUTF2: view

No data available for Gene Families for NUTF2 Gene

Function for NUTF2 Gene

Molecular function for NUTF2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.

Gene Ontology (GO) - Molecular Function for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7744965
GO:0008320 protein transmembrane transporter activity IDA 7744965
GO:0008536 Ran GTPase binding IPI 18266911
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with NUTF2: view
genes like me logo Genes that share phenotypes with NUTF2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTF2 Gene

Localization for NUTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTF2 Gene

Cytoplasm, cytosol. Nucleus outer membrane. Nucleus, nuclear pore complex. Nucleus inner membrane. Nucleus, nucleoplasm. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000269 PubMed:10679025}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUTF2 Gene COMPARTMENTS Subcellular localization image for NUTF2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005654 nucleoplasm IDA 10679025
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NUTF2: view

Pathways & Interactions for NUTF2 Gene

SuperPathways for NUTF2 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with NUTF2: view

Pathways by source for NUTF2 Gene

1 Cell Signaling Technology pathway for NUTF2 Gene

Gene Ontology (GO) - Biological Process for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 18266911
GO:0006606 protein import into nucleus IDA 7744965
GO:0006611 protein export from nucleus IDA 16449645
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NUTF2: view

No data available for SIGNOR curated interactions for NUTF2 Gene

Drugs & Compounds for NUTF2 Gene

(2) Additional Compounds for NUTF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUTF2: view

Transcripts for NUTF2 Gene

Unigene Clusters for NUTF2 Gene

Nuclear transport factor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUTF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - - - -

Relevant External Links for NUTF2 Gene

GeneLoc Exon Structure for
NUTF2
ECgene alternative splicing isoforms for
NUTF2

Expression for NUTF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NUTF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUTF2 Gene



Protein tissue co-expression partners for NUTF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUTF2 Gene:

NUTF2

SOURCE GeneReport for Unigene cluster for NUTF2 Gene:

Hs.356630
genes like me logo Genes that share expression patterns with NUTF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUTF2 Gene

Orthologs for NUTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUTF2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Nutf2-ps1 35
  • 100 (a)
OneToMany
Nutf2 34 35
  • 94.23 (n)
Nutf2-ps2 16
chimpanzee
(Pan troglodytes)
Mammalia NUTF2 34 35
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NUTF2 34 35
  • 95.8 (n)
dog
(Canis familiaris)
Mammalia NUTF2 34 35
  • 95.54 (n)
rat
(Rattus norvegicus)
Mammalia Nutf2 34
  • 93.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUTF2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUTF2 34 35
  • 76.12 (n)
lizard
(Anolis carolinensis)
Reptilia NUTF2 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nutf2 34
  • 81.1 (n)
Str.10710 34
African clawed frog
(Xenopus laevis)
Amphibia nutf2-prov 34
zebrafish
(Danio rerio)
Actinopterygii nutf2 34 35
  • 78.22 (n)
wufb40a01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9725 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007024 34
  • 53.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ntf-2r 34 35
  • 51.82 (n)
Ntf-2 35
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-4 34 35
  • 54.4 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR013W 34
  • 51.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13508g 34
  • 48.99 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTF2 34 35 37
  • 48.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NTF2B 34
  • 49.42 (n)
rice
(Oryza sativa)
Liliopsida Os08g0532300 34
  • 51.44 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nxt2 34
  • 54.8 (n)
Species where no ortholog for NUTF2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUTF2 Gene

ENSEMBL:
Gene Tree for NUTF2 (if available)
TreeFam:
Gene Tree for NUTF2 (if available)

Paralogs for NUTF2 Gene

No data available for Paralogs for NUTF2 Gene

Variants for NUTF2 Gene

Sequence variations from dbSNP and Humsavar for NUTF2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11075660 -- 67,851,877(+) TGAGC(A/G)TGGTG intron-variant
rs1110922 -- 67,855,419(+) TGTCT(G/T)GGGCG intron-variant
rs111315946 -- 67,855,890(+) GGCGG(C/G)GGGGG intron-variant
rs1113232 -- 67,845,924(+) AAACT(A/C)TTGTG intron-variant, upstream-variant-2KB
rs111402573 -- 67,850,508(+) GCCGT(C/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUTF2 Gene

Variant ID Type Subtype PubMed ID
nsv1131269 CNV deletion 24896259
nsv1844 CNV deletion 18451855
nsv478420 CNV novel sequence insertion 20440878
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv977988 CNV duplication 23825009
nsv984342 CNV duplication 23825009

Variation tolerance for NUTF2 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUTF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTF2 Gene

Disorders for NUTF2 Gene

Relevant External Links for NUTF2

Genetic Association Database (GAD)
NUTF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUTF2

No disorders were found for NUTF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUTF2 Gene

Publications for NUTF2 Gene

  1. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (PMID: 7744965) Paschal B.M. … Gerace L. (J. Cell Biol. 1995) 2 3 4 22 64
  2. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K. … Gettemans J. (Traffic 2008) 3 4 22 64
  3. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. (PMID: 10679025) Steggerda S.M. … Paschal B.M. (Mol. Biol. Cell 2000) 3 4 22 64
  4. Isolation of cDNA coding for the placental protein 15 (PP15). (PMID: 3380696) Grundmann U. … Kuepper H.A. (Nucleic Acids Res. 1988) 2 3 4 64
  5. Common variants at 30 loci contribute to polygenic dyslipidemia. (PMID: 19060906) Kathiresan S. … Cupples L.A. (Nat. Genet. 2009) 3 46 64

Products for NUTF2 Gene

Sources for NUTF2 Gene

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