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Aliases for NUTF2 Gene

Aliases for NUTF2 Gene

  • Nuclear Transport Factor 2 2 3 5
  • Placental Protein 15 3 4
  • NTF-2 3 4
  • NTF2 3 4
  • PP15 3 4

External Ids for NUTF2 Gene

Previous GeneCards Identifiers for NUTF2 Gene

  • GC16P058575
  • GC16P068258
  • GC16P067616
  • GC16P067657
  • GC16P066438
  • GC16P067880
  • GC16P053772

Summaries for NUTF2 Gene

Entrez Gene Summary for NUTF2 Gene

  • This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]

GeneCards Summary for NUTF2 Gene

NUTF2 (Nuclear Transport Factor 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include transporter activity and Ran GTPase binding.

UniProtKB/Swiss-Prot for NUTF2 Gene

  • Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.

Gene Wiki entry for NUTF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTF2 Gene

Genomics for NUTF2 Gene

Regulatory Elements for NUTF2 Gene

Enhancers for NUTF2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUTF2 on UCSC Golden Path with GeneCards custom track

Promoters for NUTF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUTF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUTF2 Gene

Chromosome:
16
Start:
67,846,732 bp from pter
End:
67,872,567 bp from pter
Size:
25,836 bases
Orientation:
Plus strand

Genomic View for NUTF2 Gene

Genes around NUTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTF2 Gene

Proteins for NUTF2 Gene

  • Protein details for NUTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61970-NTF2_HUMAN
    Recommended name:
    Nuclear transport factor 2
    Protein Accession:
    P61970
    Secondary Accessions:
    • B2R4G7
    • P13662
    • Q6IB67

    Protein attributes for NUTF2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Homodimer (PubMed:7744965). Interacts with NUP58.

    Three dimensional structures from OCA and Proteopedia for NUTF2 Gene

neXtProt entry for NUTF2 Gene

Proteomics data for NUTF2 Gene at MOPED

Post-translational modifications for NUTF2 Gene

  • Ubiquitination at Lys 55
  • Modification sites at PhosphoSitePlus

Other Protein References for NUTF2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NUTF2 (NUTF2)
  • Abcam antibodies for NTF2

No data available for DME Specific Peptides for NUTF2 Gene

Domains & Families for NUTF2 Gene

Protein Domains for NUTF2 Gene

Suggested Antigen Peptide Sequences for NUTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61970

UniProtKB/Swiss-Prot:

NTF2_HUMAN :
  • Contains 1 NTF2 domain.
Domain:
  • Contains 1 NTF2 domain.
genes like me logo Genes that share domains with NUTF2: view

No data available for Gene Families for NUTF2 Gene

Function for NUTF2 Gene

Molecular function for NUTF2 Gene

UniProtKB/Swiss-Prot Function:
Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.
genes like me logo Genes that share phenotypes with NUTF2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUTF2 Gene

Localization for NUTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTF2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUTF2 Gene COMPARTMENTS Subcellular localization image for NUTF2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
cytoskeleton 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005640 nuclear outer membrane IEA --
GO:0005829 cytosol TAS 7744965
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with NUTF2: view

Pathways & Interactions for NUTF2 Gene

SuperPathways for NUTF2 Gene

Superpath Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with NUTF2: view

Pathways by source for NUTF2 Gene

1 Cell Signaling Technology pathway for NUTF2 Gene

Gene Ontology (GO) - Biological Process for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006611 protein export from nucleus IDA 16449645
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with NUTF2: view

No data available for SIGNOR curated interactions for NUTF2 Gene

Drugs & Compounds for NUTF2 Gene

(2) Additional Compounds for NUTF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUTF2: view

Transcripts for NUTF2 Gene

Unigene Clusters for NUTF2 Gene

Nuclear transport factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUTF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - - - -

Relevant External Links for NUTF2 Gene

GeneLoc Exon Structure for
NUTF2
ECgene alternative splicing isoforms for
NUTF2

Expression for NUTF2 Gene

mRNA expression in normal human tissues for NUTF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUTF2 Gene



SOURCE GeneReport for Unigene cluster for NUTF2 Gene Hs.356630

genes like me logo Genes that share expression patterns with NUTF2: view

Protein tissue co-expression partners for NUTF2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUTF2 Gene

Orthologs for NUTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUTF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUTF2 35
  • 95.8 (n)
  • 100 (a)
NUTF2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUTF2 35
  • 95.54 (n)
  • 100 (a)
NUTF2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nutf2 35
  • 94.23 (n)
  • 100 (a)
Nutf2-ps2 16
Nutf2 36
  • 100 (a)
OneToMany
Nutf2-ps1 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia NUTF2 35
  • 99.74 (n)
  • 100 (a)
NUTF2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nutf2 35
  • 93.18 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NUTF2 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUTF2 35
  • 76.12 (n)
  • 81.1 (a)
NUTF2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUTF2 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nutf2 35
  • 81.1 (n)
  • 88.19 (a)
Str.10710 35
African clawed frog
(Xenopus laevis)
Amphibia nutf2-prov 35
zebrafish
(Danio rerio)
Actinopterygii nutf2 35
  • 78.22 (n)
  • 92.13 (a)
wufb40a01 35
nutf2 36
  • 92 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9725 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007024 35
  • 53.33 (n)
  • 44.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ntf-2r 35
  • 51.82 (n)
  • 44.54 (a)
Ntf-2 36
  • 41 (a)
OneToMany
Ntf-2r 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-4 35
  • 54.4 (n)
  • 47.2 (a)
ran-4 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR013W 35
  • 51.01 (n)
  • 45.22 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13508g 35
  • 48.99 (n)
  • 44.35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTF2 35
  • 48.99 (n)
  • 45.22 (a)
NTF2 36
  • 40 (a)
OneToOne
NTF2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NTF2B 35
  • 49.42 (n)
  • 42.98 (a)
rice
(Oryza sativa)
Liliopsida Os08g0532300 35
  • 51.44 (n)
  • 45.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nxt2 35
  • 54.8 (n)
  • 47.46 (a)
Species with no ortholog for NUTF2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUTF2 Gene

ENSEMBL:
Gene Tree for NUTF2 (if available)
TreeFam:
Gene Tree for NUTF2 (if available)

Paralogs for NUTF2 Gene

genes like me logo Genes that share paralogs with NUTF2: view

No data available for Paralogs for NUTF2 Gene

Variants for NUTF2 Gene

Sequence variations from dbSNP and Humsavar for NUTF2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8062294 -- 67,851,554(+) tacaa(C/T)ttgca intron-variant
rs13331205 -- 67,853,629(+) ggatt(A/C)caggc intron-variant
rs13333801 -- 67,851,907(+) gctac(C/T)cagga intron-variant
rs13334918 -- 67,867,440(+) GCAGA(A/G)GCCCT intron-variant
rs61412497 -- 67,855,898(+) GGGGG(-/GG)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUTF2 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906813 CNV Loss 21882294
nsv1844 CNV Loss 18451855

Variation tolerance for NUTF2 Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.89% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NUTF2 Gene

Disorders for NUTF2 Gene

Relevant External Links for NUTF2

Genetic Association Database (GAD)
NUTF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUTF2

No disorders were found for NUTF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUTF2 Gene

Publications for NUTF2 Gene

  1. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (PMID: 7744965) Paschal B.M. … Gerace L. (J. Cell Biol. 1995) 2 3 4 23 67
  2. Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. (PMID: 19404486) Li B. … Tang S.B. (Mol. Vis. 2009) 3 23
  3. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K. … Gettemans J. (Traffic 2008) 3 23
  4. Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2. (PMID: 15522285) Cushman I. … Moore M.S. (J. Mol. Biol. 2004) 3 23
  5. Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha. (PMID: 11310559) Freire J. … Freire M. (Biochem. Cell Biol. 2001) 3 23

Products for NUTF2 Gene

Sources for NUTF2 Gene

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