Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUTF2 Gene

protein-coding   GIFtS: 56
GCID: GC16P067880

Nuclear Transport Factor 2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Transport Factor 21 2
Placental Protein 152 3
NTF-22 3
NTF22 3
PP152 3

External Ids:    HGNC: 137221   Entrez Gene: 102042   Ensembl: ENSG000001028987   OMIM: 6058135   UniProtKB: P619703   

Export aliases for NUTF2 gene to outside databases

Previous GC identifers: GC16P058575 GC16P068258 GC16P067616 GC16P067657 GC16P066438 GC16P053772


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUTF2 Gene:
The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It
interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of
nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is
thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during
nuclear import. (provided by RefSeq, Jul 2008)

GeneCards Summary for NUTF2 Gene: 
NUTF2 (nuclear transport factor 2) is a protein-coding gene. Diseases associated with NUTF2 include skin tag, and lung adenocarcinoma. GO annotations related to this gene include protein binding and transporter activity.

UniProtKB/Swiss-Prot: NTF2_HUMAN, P61970
Function: Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at
a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at
the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore
complex during nuclear import

Gene Wiki entry for NUTF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUTF2 gene promoter:
         Nkx3-1   RFX1   Nkx3-1 v4   ATF-2   MyoD   Nkx3-1 v1   GATA-2   CRE-BP1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUTF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUTF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUTF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

NUTF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUTF2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067880:  view genomic region     (about GC identifiers)

Start:
67,880,635 bp from pter      End:
67,906,470 bp from pter
Size:
25,836 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTF2_HUMAN, P61970 (See protein sequence)
Recommended Name: Nuclear transport factor 2  
Size: 127 amino acids; 14478 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for NUTF2:
1GY5 (3D)    
Secondary accessions: B2R4G7 P13662 Q6IB67

Explore the universe of human proteins at neXtProt for NUTF2: NX_P61970

Explore proteomics data for NUTF2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61970

  • NUTF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUTF2 Protein Expression
    REFSEQ proteins: NP_005787.1  
    ENSEMBL proteins: 
     ENSP00000219169   ENSP00000456428   ENSP00000457989   ENSP00000457022  

    Human Recombinant Protein Products for NUTF2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NUTF2
    OriGene Protein Over-expression Lysate for NUTF2
    OriGene MassSpec for NUTF2 
    OriGene Custom Protein Services for NUTF2
    GenScript Custom Purified and Recombinant Proteins Services for NUTF2
    Novus Biologicals NUTF2 Proteins
    Novus Biologicals NUTF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NUTF2
    Cloud-Clone Corp. Proteins for NUTF2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005643nuclear pore TAS7744965
    GO:0005829cytosol TAS7744965
    GO:0015630microtubule cytoskeleton IDA--

    NUTF2 for ontologies           About GeneDecksing



    NUTF2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NUTF2 
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NUTF2
    GenScript Custom Superior Antibodies Services for NUTF2
    Novus Biologicals NUTF2 Antibodies
    Abcam antibodies for NUTF2
    Cloud-Clone Corp. Antibodies for NUTF2 
    ThermoFisher Antibodies for NUTF2
    LSBio Antibodies in human, mouse, rat for NUTF2 

    Assay Products for NUTF2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NUTF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUTF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NUTF2 
    Cloud-Clone Corp. CLIAs for NUTF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002075 NTF2
     IPR018222 Nuclear_transport_factor_2_euk

    Graphical View of Domain Structure for InterPro Entry P61970

    ProtoNet protein and cluster: P61970

    UniProtKB/Swiss-Prot: NTF2_HUMAN, P61970
    Similarity: Contains 1 NTF2 domain


    NUTF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTF2_HUMAN, P61970
    Function: Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at
    a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at
    the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore
    complex during nuclear import

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS7744965
    GO:0005515protein binding IPI7744965
         
    NUTF2 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for NUTF2:
     Cell division defect  Decreased cell number, increas  Decreased influenza A virus in  Decreased viability of wild-ty 
     Increased gamma-H2AX phosphory  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects  Nucleoplasmic pre-40S maturati 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUTF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUTF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUTF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUTF2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUTF2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NUTF2 (see all 13):
    hsa-miR-3910 hsa-miR-7-2* hsa-miR-765 hsa-miR-3647-3p hsa-miR-223 hsa-miR-9 hsa-miR-3658 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidNUTF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUTF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUTF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NUTF2
    Sirion Biotech Customized adenovirus for overexpression of NUTF2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NUTF2 (see all 7)
    OriGene ORF clones in mouse, rat for NUTF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUTF2 (NM_005796)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUTF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUTF2
    Sirion Biotech Customized lentivirus for stable overexpression of NUTF2 
                         Customized lentivirus expression plasmids for stable overexpression of NUTF2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NUTF2
    Search LifeMap BioReagents cell lines for NUTF2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUTF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUTF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NUTF2
        Cytoskeletal Signaling



    NUTF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUTF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for NUTF2 (P619702, 3 ENSP000002191694) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LUC7L2Q9Y3832, 3MINT-63951 I2D: score=5 
    C7orf55-LUC7L2Q9Y3832, 3, ENSP000003470054MINT-63951 I2D: score=5 STRING: ENSP00000347005
    RANP628263, ENSP000003961274I2D: score=5 STRING: ENSP00000396127
    CDKN1BP465273, ENSP000002288724I2D: score=2 STRING: ENSP00000228872
    NUP54Q7Z3B43, ENSP000002648834I2D: score=2 STRING: ENSP00000264883
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006611protein export from nucleus IDA16449645
    GO:0006810transport ----

    NUTF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NUTF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUTF2 (NTF2)

    2 Novoseek inferred chemical compound relationships for NUTF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 60.5 8 9533885 (2), 15155737 (2), 8755535 (1), 10679025 (1)
    gtp 49.2 3 8755535 (2)

    Search CenterWatch for drugs/clinical trials and news about NUTF2 / NTF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUTF2 gene: 
    NM_005796.1  

    Unigene Cluster for NUTF2:

    Nuclear transport factor 2
    Hs.356630  [show with all ESTs]
    Unigene Representative Sequence: BX647782
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219169(uc002eup.3) ENST00000568390(uc010vkf.1) ENST00000568233
    ENST00000567105 ENST00000569436 ENST00000568396 ENST00000570026

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUTF2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NUTF2 (see all 13):
    hsa-miR-3910 hsa-miR-7-2* hsa-miR-765 hsa-miR-3647-3p hsa-miR-223 hsa-miR-9 hsa-miR-3658 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidNUTF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUTF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUTF2
    Clone
    Products:
         
    OriGene clones in human, mouse for NUTF2 (see all 7)
    OriGene ORF clones in mouse, rat for NUTF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUTF2 (NM_005796)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUTF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUTF2
    Sirion Biotech Customized lentivirus for stable overexpression of NUTF2 
                         Customized lentivirus expression plasmids for stable overexpression of NUTF2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NUTF2
    OriGene qSTAR qPCR primer pairs in human, mouse for NUTF2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUTF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUTF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUTF2

    Additional mRNA sequence: 

    AK293739.1 AK311822.1 BC002348.2 BC033653.2 BX647782.1 CR456937.1 U43939.1 X07315.1 

    19 DOTS entries:

    DT.100741225  DT.100060431  DT.100694165  DT.95206076  DT.100741231  DT.100803779  DT.100720042  DT.100741249 
    DT.101987213  DT.92442526  DT.100803270  DT.120914085  DT.95323199  DT.100741241  DT.100850448  DT.101968257 
    DT.95190037  DT.95240525  DT.92442519 

    24/339 AceView cDNA sequences (see all 339):

    BM785274 AI565697 BX282465 BM784668 BE409333 F26545 X07315 CB162894 
    CR621534 BF036275 CR621108 BX352783 BX647782 BQ223004 BQ878472 BQ687109 
    CR610795 BX347529 AI343249 BQ051424 BP346802 BQ674733 BM695805 AA775831 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUTF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
    SP1:              -     -           -     -     -                       -                                 
    SP2:                                            -                       -                                 
    SP3:              -     -     -     -     -     -                       -                                 
    SP4:                                -     -     -                       -                                 
    SP5:                                      -     -                       -                                 


    ECgene alternative splicing isoforms for NUTF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUTF2 expression in normal human tissues (normalized intensities)      NUTF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACAATAAA
    NUTF2 Expression
    About this image


    NUTF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Tooth (Integumentary System)    fully expand to see all 5 entries
             visceral organ/oral region/upper jaw   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Intervertebral Disc Nucleus Pulposus Cells Lumbar Intervertebral Disc
             sensory organ/ear/inner ear   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Endochondral Facial Bones
             sensory organ/ear/inner ear   

    See NUTF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUTF2

    SOURCE GeneReport for Unigene cluster: Hs.356630
        SABiosciences Custom PCR Arrays for NUTF2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NUTF2
    OriGene qSTAR qPCR primer pairs in human, mouse for NUTF2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUTF2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUTF2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUTF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUTF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NUTF2 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nutf21 , 5 nuclear transport factor 21, 5 94.23(n)1
    100(a)1
      8 (53.05 cM)5
    680511  NM_026532.31  NP_080808.11 
     1058606345 
    chicken
    (Gallus gallus)
    Aves NUTF21 nuclear transport factor 2 76.12(n)
    81.1(a)
      415655  NM_001030562.1  NP_001025733.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUTF26
    nuclear transport factor 2
    80(a)
    1 ↔ 1
    GL343295.1(609635-626317)
    African clawed frog
    (Xenopus laevis)
    Amphibia nutf2-prov2 nuclear transport factor 2 80.25(n)    BC054170.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb40a012 Transcribed sequence with strong similarity to protein more 79.28(n)    57040808 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ntf-2r1 Nuclear transport factor-2-related 51.82(n)
    44.54(a)
      35101  NM_136034.1  NP_609878.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ran-41 Protein RAN-4 54.4(n)
    47.2(a)
      172648  NM_059921.3  NP_492322.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTF2(YER009W)4 Nuclear envelope protein, interacts with GDP-bound more   --   5(172115-172492) 856727  NP_010925.1 


    ENSEMBL Gene Tree for NUTF2 (if available)
    TreeFam Gene Tree for NUTF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUTF2 gene

    NUTF2 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for NUTF2 (see all 8)
    PGOHUM00000238676 PGOHUM00000248136 PGOHUM00000247088 PGOHUM00000237162 PGOHUM00000244851


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/327 SNPs in NUTF2 are shown (see all 327)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474826851,2
    --67883393(+) GCGCAC/TGCCAC 1 -- int10--------
    rs1383383511,2
    --67883540(+) ATCCCA/GGCCTA 1 -- int10--------
    rs1832448511,2
    --67883556(+) ATTTTC/TATTTT 1 -- int10--------
    rs1891005181,2
    --67883657(+) CCCGGA/GTTCAC 1 -- int10--------
    rs1437941571,2
    --67883763(+) TCACCA/GTGTTA 1 -- int10--------
    rs99332681,2
    C,F,H--67883783(+) gtctcG/Aatctc 1 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1405836711,2
    --67883829(+) GTGCCA/GGGATT 1 -- int10--------
    rs1908717341,2
    --67883966(+) CTGGGA/CTTACA 1 -- int10--------
    rs595480581,2
    C,F--67884015(+) CAGGGA/TCAAAA 1 -- int14Minor allele frequency- T:0.21WA CSA 124
    rs1167077511,2
    C,F--67884040(+) CTCCAA/TCGTTA 1 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for NUTF2 (67880635 - 67906470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUTF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1844CNV Loss18451855
    nsv906813CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NUTF2
    DNA2.0 Custom Variant and Variant Library Synthesis for NUTF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605813    OMIM disorders: --

    9 diseases for NUTF2:    About MalaCards
    skin tag    lung adenocarcinoma    diabetic retinopathy    coronary heart disease
    retinoblastoma    hypoxia    tuberculosis    alzheimer's disease
    adenocarcinoma


    NUTF2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NUTF2

    Export disorders for NUTF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUTF2 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with NUTF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (PubMed id 7744965)1, 2, 3, 9 Paschal B.M. and Gerace L. (1995)
    2. Isolation of cDNA coding for the placental protein 15 (PP15). (PubMed id 3380696)1, 2, 3 Grundmann U....Kupper H.A. (1988)
    3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (2009)
    4. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1, 4 Aulchenko Y.S....Peltonen L. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. (PubMed id 9533885)1, 9 Stewart M....McCoy A.J. (1998)
    7. Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. (PubMed id 19404486)1, 9 Li B....Tang S.B. (2009)
    8. Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran. (PubMed id 9368653)1, 9 Clarkson W.D....Stewart M. (1997)
    9. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. (PubMed id 10679025)1, 9 Steggerda S.M....Paschal B.M. (2000)
    10. Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2). (PubMed id 11129791)1, 9 Stewart M. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10204 HGNC: 13722 AceView: NUTF2 Ensembl:ENSG00000102898 euGenes: HUgn10204
    ECgene: NUTF2 H-InvDB: NUTF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUTF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUTF2 gene:
    Search GeneIP for patents involving NUTF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NUTF2  
     OriGene qPCR primer pairs and template standards for NUTF2   OriGene Protein Over-expression Lysate for NUTF2  
     OriGene MassSpec something-or-other for NUTF2   OriGene clones in human, mouse for NUTF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NUTF2   OriGene Purified Protein for NUTF2  
     OriGene ORF clones in mouse, rat for NUTF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUTF2   OriGene Custom Protein Services for NUTF2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUTF2
     QIAGEN SeqTarget long-range PCR primers for resequencing NUTF2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUTF2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUTF2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUTF2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUTF2
     GenScript Custom Purified and Recombinant Proteins Services for NUTF2 GenScript cDNA clones with any tag delivered in your preferred vector for NUTF2
     GenScript Custom Assay Services for NUTF2 GenScript Custom Superior Antibodies Services for NUTF2
     GenScript Custom overexpressing Cell Line Services for NUTF2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for NUTF2 

     Regulatory tfbs in NUTF2 promoter
     Search Chromatin IP Primers for NUTF2
     RT2 qPCR Primer Assay in human, mouse, rat NUTF2
     GNC Network for NUTF2
     SABiosciences Custom PCR Arrays for NUTF2
     Search Tocris compounds for NUTF2 (NTF2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NUTF2 antibodies
     NUTF2 proteins
     NUTF2 lysates
     Antibodies for NUTF2
     See all of Abcam's Antibodies, Kits and Proteins for NUTF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NUTF2




     Proteins for NUTF2
     Antibodies for NUTF2
     ELISAs for NUTF2
     CLIAs for NUTF2
     Search LifeMap BioReagents cell lines for NUTF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUTF2
     SwitchGear 3'UTR luciferase reporter plasmids for NUTF2
     SwitchGear Promoter luciferase reporter plasmids for NUTF2
     ThermoFisher Antibodies for NUTF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUTF2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NUTF2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUTF2
    Customized:
     lentivirus for stable overexpression of NUTF2
     lentivirus expression plasmids for stable overexpression of NUTF2
     adenovirus for overexpression of NUTF2
     LSBio Antibodies in human, mouse, rat for NUTF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NUTF2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4