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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUTF2 Gene

protein-coding   GIFtS: 54
GCID: GC16P067880

nuclear transport factor 2
 Explore 11 diseases affiliated with
NUTF2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUTF2    

Aliases
for NUTF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Transport Factor 21 2
NTF21 2 3
PP151 2 3
Placental Protein 152 3
NTF-22 3

External Ids:    HGNC: 137221   Entrez Gene: 102042   Ensembl: ENSG000001028987   OMIM: 6058135   UniProtKB: P619703   

Export aliases for NUTF2 gene to outside databases

Previous GC identifers: GC16P058575 GC16P068258 GC16P067616 GC16P067657 GC16P066438 GC16P053772


Summaries
for NUTF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NUTF2:
The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It
interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of
nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is
thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear
import. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NTF2_HUMAN, P61970
Function: Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a
relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the
nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex
during nuclear import

Gene Wiki entry for NUTF2


Genomic Views
for NUTF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUTF2 gene promoter:
         Nkx3-1   RFX1   Nkx3-1 v4   ATF-2   MyoD   Nkx3-1 v1   GATA-2   CRE-BP1   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUTF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUTF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUTF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

NUTF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUTF2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067880:  view genomic region     (about GC identifiers)

Start:
 67,880,635 bp from pter      End:
 67,906,470 bp from pter
Size:
 25,836 bases      Orientation:
 plus strand

Proteins
for NUTF2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NTF2_HUMAN, P61970 (See protein sequence)
Recommended Name: Nuclear transport factor 2  
Size: 127 amino acids; 14478 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for NUTF2:
1GY5 (3D)    
Secondary accessions: B2R4G7 P13662 Q6IB67

Explore the universe of human proteins at neXtProt for NUTF2: NX_P61970

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61970

    • NUTF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005787.1  
    ENSEMBL proteins: 
     ENSP00000219169   ENSP00000464456   ENSP00000456428   ENSP00000457989   ENSP00000457022  

    Human Recombinant Protein Products: 
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    Novus Biologicals NUTF2 Proteins
    Novus Biologicals NUTF2 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NUTF2
    Uscn Proteins for NUTF2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005643nuclear pore TAS7744965
    GO:0005829cytosol TAS7744965
    GO:0015630microtubule cytoskeleton IDA--


    NUTF2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NUTF2

    Protein Domains /
    Families
    for NUTF2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUTF2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR002075 NTF2
     IPR018222 Nuclear_transport_factor_2_euk

    Graphical View of Domain Structure for InterPro Entry P61970

    ProtoNet protein and cluster: P61970

    UniProtKB/Swiss-Prot: NTF2_HUMAN, P61970
    Similarity: Contains 1 NTF2 domain


    Function
    for NUTF2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NTF2_HUMAN, P61970
    Function: Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a
    relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the
    nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex
    during nuclear import

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUTF2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NUTF2 (see all 13):
    hsa-miR-3910 hsa-miR-7-2* hsa-miR-765 hsa-miR-3647-3p hsa-miR-223 hsa-miR-9 hsa-miR-3658 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: NUTF2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUTF2 (see all 7)
    OriGene shRNA RFP: NUTF2
    OriGene siRNA: NUTF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUTF2

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for NUTF2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS7744965
    GO:0005515protein binding IPI7744965


    NUTF2 for ontologies           About GeneDecksing


    8 GenomeRNAi human phenotypes for NUTF2:
     Cell division defect  Decreased cell number, increas  Decreased influenza A virus in  Decreased viability of wild-ty 
     Increased gamma-H2AX phosphory  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects  Nucleoplasmic pre-40S maturati 


    Pathways & Interactions
    for NUTF2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NUTF2
        Cytoskeletal Signaling



    NUTF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUTF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for NUTF2 (P619702, 3 ENSP000002191694) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-63951 I2D: score=5 
    LUC7L2Q9Y3832, 3, ENSP000003470054MINT-63951 I2D: score=5 STRING: ENSP00000347005
    RANP628263, ENSP000003961274I2D: score=5 STRING: ENSP00000396127
    CDKN1BP465273, ENSP000002288724I2D: score=2 STRING: ENSP00000228872
    NUP54Q7Z3B43, ENSP000002648834I2D: score=2 STRING: ENSP00000264883
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006611protein export from nucleus IDA16449645
    GO:0006810transport ----


    NUTF2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NUTF2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NUTF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUTF2
    2 Novoseek chemical compound relationships for NUTF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 60.5 8 9533885 (2), 15155737 (2), 8755535 (1), 10679025 (1)
    gtp 49.2 3 8755535 (2)

    Search CenterWatch for drugs/clinical trials and news about NUTF2 / NTF2 

    Transcripts
    for NUTF2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUTF2 gene: 
    NM_005796.1  

    Unigene Cluster for NUTF2:

    Nuclear transport factor 2
    Hs.744185  [show with all ESTs]
    Unigene Representative Sequence: BX647782
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219169(uc002eup.3) ENST00000568390(uc010vkf.1) ENST00000568233
    ENST00000567105 ENST00000569436 ENST00000568396 ENST00000570026

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NUTF2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUTF2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate NUTF2 (see all 13):
    hsa-miR-3910 hsa-miR-7-2* hsa-miR-765 hsa-miR-3647-3p hsa-miR-223 hsa-miR-9 hsa-miR-3658 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmid: NUTF2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUTF2 (see all 7)
    OriGene shRNA RFP: NUTF2
    OriGene siRNA: NUTF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUTF2
    Clone
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    GenScript: all cDNA clones in your preferred vector: NUTF2 (NM_005796)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUTF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUTF2

    Additional cDNA sequence: 

    AK293739.1 AK311822.1 BC002348.2 BC033653.2 BX647782.1 CR456937.1 U43939.1 X07315.1 

    19 DOTS entries:

    DT.100741225  DT.100060431  DT.100694165  DT.95206076  DT.100741231  DT.100803779  DT.100720042  DT.100741249 
    DT.101987213  DT.100803270  DT.120914085  DT.92442526  DT.95323199  DT.100741241  DT.100850448  DT.101968257 
    DT.95190037  DT.95240525  DT.92442519 

    24/339 AceView cDNA sequences (see all 339):

    BX352783 BQ051424 BM798636 BQ878472 BQ674733 BU619940 CB113171 CR613501 
    AI004415 BX509927 BX347529 BG472769 U43939 BX385552 BX359804 N34463 
    AI686142 BQ772290 CR621393 BM479854 BQ006626 AA314085 CD679094 CR611844 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUTF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
    SP1:              -     -           -     -     -                       -                                 
    SP2:                                            -                       -                                 
    SP3:              -     -     -     -     -     -                       -                                 
    SP4:                                -     -     -                       -                                 
    SP5:                                      -     -                       -                                 


    ECgene alternative splicing isoforms for NUTF2

    Expression
    for NUTF2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUTF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATACAATAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NUTF2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    BoneEndochondral Facial BonesBone
    BrainCerebral CortexBrain
    KidneyMetanephrosKidney
    LiverLiver LobuleLiver
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeTelencephalonNeural Tube
    Primitive StreakNotochordPrimitive Streak
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NUTF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUTF2

    SOURCE GeneReport for Unigene cluster: Hs.744185
        SABiosciences Custom PCR Arrays for NUTF2
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    In Situ
    Assay Products:     
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    Orthologs
    for NUTF2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUTF2 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nutf21 , 5 nuclear transport factor 21, 5 94.23(n)1
    100(a)1    		   8 (53.05 cM)5
    680511  NM_026532.31  NP_080808.11 
     1058606345 
    chicken
    (Gallus gallus)    		 Aves NUTF21 nuclear transport factor 2 76.12(n)
    81.1(a)    		   415655  NM_001030562.1  NP_001025733.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NUTF26
    		 --
    		 96(a)
    		 1 ↔ 1
    		 GL343295.1(612257-619985)
    African clawed frog
    (Xenopus laevis)    		 Amphibia nutf2-prov2 nuclear transport factor 2 80.25(n)    BC054170.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb40a012 Transcribed sequence with strong similarity to protein more 79.28(n)    57040808 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ntf-2r1 Nuclear transport factor-2-related 51.82(n)
    44.54(a)    		   35101  NM_136034.1  NP_609878.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ran-41 Protein RAN-4 54.4(n)
    47.2(a)    		   172648  NM_059921.3  NP_492322.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NTF2A6
    NTL6
    (see all 3)    		 nuclear transport factor 2-like protein
    (see all 3)    		 36(a)
    36(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 1(9484316-9485896)
    1(3883280-3883956)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 nuclear transport factor, putative, expressed
    		 39(a)
    		 1 ↔ 1
    		 8(26532343-26534675)


    ENSEMBL Gene Tree for NUTF2 (if available)
    TreeFam Gene Tree for NUTF2 (if available) 

    Paralogs
    for NUTF2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUTF2 gene

    NUTF2 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for NUTF2 (see all 8)
    PGOHUM00000238676 PGOHUM00000248136 PGOHUM00000247088 PGOHUM00000237162 PGOHUM00000244851


    Genomic Variants
    for NUTF2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/339 NCBI SNPs in NUTF2 are shown (see all 339)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1487312481,2
    		--67878912(+) GTCTCC/GAGCTC 2 -- int1 us2k10--------
    rs582560131,2
    		C,F,--67878935(+) GATCCG/ACCTGC 2 -- int1 us2k15Minor allele frequency- A:0.22WA CSA 125
    rs1414263591,2
    		C,--67879103(+) AAGCTC/GTGGGT 2 -- us2k1 int10--------
    rs118664551,2
    		C,F,A,H,--67879285(+) GTTGGG/AAAAGT 2 -- int1 us2k112Minor allele frequency- A:0.02NS EA NA WA 1452
    rs1163110031,2
    		--67879311(+) AGACAT/CAGGTT 2 -- us2k1 int11Minor allele frequency- C:0.01WA 118
    rs38096301,2
    		C,F,H,--67879400(+) GCACTG/ACAGTG 2 -- int1 us2k118Minor allele frequency- A:0.09EA NS NA WA 3706
    rs1508339321,2
    		--67879444(+) CTTCCC/GGGTCG 2 -- us2k1 int10--------
    rs1398487641,2
    		--67879636(+) GTTCAC/TAGAGC 2 -- int1 us2k10--------
    rs11132321,2
    		C,F,H,--67879827(+) AAACTC/ATTGTG 2 -- us2k1 int115Minor allele frequency- A:0.03MN NS EA NA 1936
    rs1834925741,2
    		--67880035(+) AGGGCA/GATGGG 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for NUTF2 (67880635 - 67906470 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NUTF2
         1 CNV: 35395

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    Disorders / Diseases
    for NUTF2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUTF2 for disorders           About GeneDecksing

    OMIM gene information: 605813    OMIM disorders: --

    11 diseases for NUTF2:    About MalaCards
    skin tag    coronary heart disease    diabetic retinopathy    lung adenocarcinoma
    alzheimer's disease    retinoblastoma    adenocarcinoma    hypoxia
    tuberculosis    malaria    mycobacterium tuberculosis


    Export disorders for NUTF2 gene to outside databases

    Publications
    for NUTF2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUTF2 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with NUTF2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (PubMed id 7744965)1, 2, 3, 9 Paschal B.M. and Gerace L. (1995)
    2. Isolation of cDNA coding for the placental protein 15 (PP15). (PubMed id 3380696)1, 2, 3 Grundmann U....Kupper H.A. (1988)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. (PubMed id 9533885)1, 9 Stewart M....McCoy A.J. (1998)
    5. Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. (PubMed id 19404486)1, 9 Li B....Tang S.B. (2009)
    6. Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran. (PubMed id 9368653)1, 9 Clarkson W.D....Stewart M. (1997)
    7. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. (PubMed id 10679025)1, 9 Steggerda S.M....Paschal B.M. (2000)
    8. Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2). (PubMed id 11129791)1, 9 Stewart M. (2000)
    9. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PubMed id 18266911)1, 9 Van Impe K....Gettemans J. (2008)
    10. Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2. (PubMed id 15522285)1, 9 Cushman I....Moore M.S. (2004)

    External Searches for NUTF2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NUTF2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10204 HGNC: 13722 AceView: NUTF2 Ensembl:ENSG00000102898 euGenes: HUgn10204
    ECgene: NUTF2 H-InvDB: NUTF2

    Other Databases showing NUTF2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NUTF2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUTF2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUTF2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUTF2 gene:
    Search GeneIP for patents involving NUTF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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