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Aliases for NUTF2 Gene

Aliases for NUTF2 Gene

  • Nuclear Transport Factor 2 2 3
  • Placental Protein 15 3 4
  • NTF-2 3 4
  • NTF2 3 4
  • PP15 3 4

External Ids for NUTF2 Gene

Summaries for NUTF2 Gene

Entrez Gene Summary for NUTF2 Gene

  • The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUTF2 Gene

NUTF2 (Nuclear Transport Factor 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling. GO annotations related to this gene include transporter activity.

UniProtKB/Swiss-Prot for NUTF2 Gene

  • Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import

Gene Wiki entry for NUTF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUTF2 Gene

Genomics for NUTF2 Gene

Genomic Location for NUTF2 Gene

Start:
67,846,732 bp from pter
End:
67,872,567 bp from pter
Size:
25,836 bases
Orientation:
Plus strand

Genomic View for NUTF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUTF2 Gene

Regulatory Elements for NUTF2 Gene

Proteins for NUTF2 Gene

  • Protein details for NUTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61970-NTF2_HUMAN
    Recommended name:
    Nuclear transport factor 2
    Protein Accession:
    P61970
    Secondary Accessions:
    • B2R4G7
    • P13662
    • Q6IB67

    Protein attributes for NUTF2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14478 Da
    Quaternary structure:
    • Homodimer

    Three dimensional structures from OCA and Proteopedia for NUTF2 Gene

neXtProt entry for NUTF2 Gene

Proteomics data for NUTF2 Gene at MOPED

Post-translational modifications for NUTF2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys55

Other Protein References for NUTF2 Gene

No data available for DME Specific Peptides for NUTF2 Gene

Domains for NUTF2 Gene

Protein Domains for NUTF2 Gene

Suggested Antigen Peptide Sequences for NUTF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61970

UniProtKB/Swiss-Prot:

NTF2_HUMAN
Domain:
  • Contains 1 NTF2 domain.:
    • P61970
genes like me logo Genes that share domains with NUTF2: view

No data available for Gene Families for NUTF2 Gene

Function for NUTF2 Gene

Molecular function for NUTF2 Gene

UniProtKB/Swiss-Prot Function: Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import

Gene Ontology (GO) - Molecular Function for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 7744965
GO:0005515 protein binding IPI 18266911
GO:0008536 Ran GTPase binding IPI 18266911
genes like me logo Genes that share ontologies with NUTF2: view
genes like me logo Genes that share phenotypes with NUTF2: view

miRNA for NUTF2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUTF2 Gene

Localization for NUTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUTF2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUTF2 Gene COMPARTMENTS Subcellular localization image for NUTF2 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005643 nuclear pore TAS 7744965
GO:0005829 cytosol TAS 7744965
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with NUTF2: view

Pathways for NUTF2 Gene

SuperPathways for NUTF2 Gene

Superpath Contained pathways
1 Cytoskeletal Signaling
genes like me logo Genes that share pathways with NUTF2: view

Pathways by source for NUTF2 Gene

1 Cell Signaling Technology pathway for NUTF2 Gene

Gene Ontology (GO) - Biological Process for NUTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 18266911
GO:0006611 protein export from nucleus IDA 16449645
GO:0006810 transport --
genes like me logo Genes that share ontologies with NUTF2: view

Compounds for NUTF2 Gene

(2) Novoseek inferred chemical compound relationships for NUTF2 Gene

Compound -log(P) Hits PubMed IDs
gdp 60.5 6
gtp 49.2 2
genes like me logo Genes that share compounds with NUTF2: view

Transcripts for NUTF2 Gene

Unigene Clusters for NUTF2 Gene

Nuclear transport factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUTF2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - - - - - -

Relevant External Links for NUTF2 Gene

GeneLoc Exon Structure for
NUTF2
ECgene alternative splicing isoforms for
NUTF2

Expression for NUTF2 Gene

mRNA expression in normal human tissues for NUTF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUTF2 Gene

SOURCE GeneReport for Unigene cluster for NUTF2 Gene Hs.356630

genes like me logo Genes that share expressions with NUTF2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUTF2 Gene

Orthologs for NUTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUTF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUTF2 35
  • 99.74 (n)
  • 100 (a)
NUTF2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUTF2 35
  • 95.8 (n)
  • 100 (a)
NUTF2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUTF2 35
  • 95.54 (n)
  • 100 (a)
NUTF2 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nutf2 35
  • 94.23 (n)
  • 100 (a)
Nutf2 16
Nutf2 36
  • 100 (a)
OneToMany
Nutf2-ps1 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NUTF2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nutf2 35
  • 93.18 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves NUTF2 35
  • 76.12 (n)
  • 81.1 (a)
NUTF2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUTF2 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nutf2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nutf2 35
  • 81.1 (n)
  • 88.19 (a)
Str.10710 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9725 35
zebrafish
(Danio rerio)
Actinopterygii nutf2 35
  • 78.22 (n)
  • 92.13 (a)
nutf2 36
  • 92 (a)
OneToOne
wufb40a01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007024 35
  • 53.33 (n)
  • 44.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ntf-2 36
  • 41 (a)
OneToMany
Ntf-2r 35
  • 51.82 (n)
  • 44.54 (a)
Ntf-2r 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-4 35
  • 54.4 (n)
  • 47.2 (a)
ran-4 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR013W 35
  • 51.01 (n)
  • 45.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTF2 35
  • 48.99 (n)
  • 45.22 (a)
NTF2 36
  • 40 (a)
OneToOne
NTF2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13508g 35
  • 48.99 (n)
  • 44.35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NTF2B 35
  • 49.42 (n)
  • 42.98 (a)
rice
(Oryza sativa)
Liliopsida Os08g0532300 35
  • 51.44 (n)
  • 45.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nxt2 35
  • 54.8 (n)
  • 47.46 (a)
Species with no ortholog for NUTF2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUTF2 Gene

ENSEMBL:
Gene Tree for NUTF2 (if available)
TreeFam:
Gene Tree for NUTF2 (if available)

Paralogs for NUTF2 Gene

genes like me logo Genes that share paralogs with NUTF2: view

No data available for Paralogs for NUTF2 Gene

Variants for NUTF2 Gene

Sequence variations from dbSNP and Humsavar for NUTF2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1110922 -- 67,855,419(+) TGTCT(G/T)GGGCG intron-variant
rs1123072 -- 67,864,894(-) AGCCT(C/T)TCCTT intron-variant
rs1124324 -- 67,863,584(+) ACCAC(C/T)GGCAC intron-variant
rs2271293 -- 67,868,167(+) GGGTA(A/G)AAGAT intron-variant
rs2271294 -- 67,868,423(+) AGGGA(A/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUTF2 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906813 CNV Loss 21882294
nsv1844 CNV Loss 18451855

Relevant External Links for NUTF2 Gene

HapMap Linkage Disequilibrium report
NUTF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUTF2 Gene

Disorders for NUTF2 Gene

Relevant External Links for NUTF2

Genetic Association Database (GAD)
NUTF2
genes like me logo Genes that share disorders with NUTF2: view

No data available for UniProtKB/Swiss-Prot for NUTF2 Gene

Publications for NUTF2 Gene

  1. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. (PMID: 7744965) Paschal B.M. … Gerace L. (J. Cell Biol. 1995) 2 3 4 23
  2. Isolation of cDNA coding for the placental protein 15 (PP15). (PMID: 3380696) Grundmann U. … Kuepper H.A. (Nucleic Acids Res. 1988) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K. … Gettemans J. (Traffic 2008) 3 23
  5. Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2). (PMID: 11129791) Stewart M. (Cell Struct. Funct. 2000) 3 23

Products for NUTF2 Gene

Sources for NUTF2 Gene

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