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NUSAP1 Gene

protein-coding   GIFtS: 50
GCID: GC15P041624

Nucleolar And Spindle Associated Protein 1

  Search for NUSAP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleolar And Spindle Associated Protein 11 2     Q03102
ANKT2 3 5     SAPL2
NUSAP2 5     Nucleolar And Spindle-Associated Protein 12
BM0372     Nucleolar Protein ANKT2
LNP2     NuSAP3
PRO0310p12     

External Ids:    HGNC: 185381   Entrez Gene: 512032   Ensembl: ENSG000001378047   OMIM: 6128185   UniProtKB: Q9BXS63   

Export aliases for NUSAP1 gene to outside databases

Previous GC identifers: GC15P039341 GC15P039412 GC15P018473


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUSAP1 Gene:
NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers
et al., 2003 (PubMed 12963707)).(supplied by OMIM, Jun 2009)

GeneCards Summary for NUSAP1 Gene:
NUSAP1 (nucleolar and spindle associated protein 1) is a protein-coding gene. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot: NUSAP_HUMAN, Q9BXS6
Function: Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity).
May associate with chromosomes and promote the organization of mitotic spindle microtubules around them




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUSAP1 gene promoter:
         Bach1   Pax-5   Bach2   MyoD   AREB6   FOXO4   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUSAP1 promoter sequence
   Search Chromatin IP Primers for NUSAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUSAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q14

NUSAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUSAP1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P041624:  view genomic region     (about GC identifiers)

Start:
41,624,892 bp from pter      End:
41,673,248 bp from pter
Size:
48,357 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUSAP_HUMAN, Q9BXS6 (See protein sequence)
Recommended Name: Nucleolar and spindle-associated protein 1  
Size: 441 amino acids; 49452 Da
Subunit: Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while
association with DNA is also inhibited by IPO7 and KPNA2 (By similarity)
Sequence caution: Sequence=AAF24034.1; Type=Frameshift; Positions=205; Sequence=AAF67624.1; Type=Frameshift;
Positions=175, 205; Sequence=AAH12887.2; Type=Erroneous initiation;
Secondary accessions: B4DDF1 E7ERR5 J3KN21 Q53GW2 Q8TBT4 Q96E58 Q96FJ1 Q9GZM9 Q9NZ85 Q9UI70
Alternative splicing: 7 isoforms:  Q9BXS6-1   Q9BXS6-2   Q9BXS6-3   Q9BXS6-4   Q9BXS6-5   Q9BXS6-6   Q9BXS6-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUSAP1: NX_Q9BXS6

Explore proteomics data for NUSAP1 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein1
  • Phosphorylation by ATM in G2/M-phase induces mitotic arrest1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NUSAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001230071.1  NP_001230072.1  NP_001230073.1  NP_057443.2  NP_060924.4  

    ENSEMBL proteins: 
     ENSP00000260359   ENSP00000452725   ENSP00000401014   ENSP00000453403   ENSP00000400746  
     ENSP00000454097   ENSP00000453657   ENSP00000453428   ENSP00000453558   ENSP00000401351  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026756 NuSAP

    Graphical View of Domain Structure for InterPro Entry Q9BXS6

    ProtoNet protein and cluster: Q9BXS6

    UniProtKB/Swiss-Prot: NUSAP_HUMAN, Q9BXS6
    Domain: The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination
    Similarity: Belongs to the NUSAP family


    Find genes that share domains with NUSAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUSAP_HUMAN, Q9BXS6
    Function: Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity).
    May associate with chromosomes and promote the organization of mitotic spindle microtubules around them

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008017microtubule binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NUSAP1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nusap1):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with NUSAP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nusap1tm1.1Gcm for NUSAP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUSAP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUSAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUSAP1

    miRNA
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    miRTarBase miRNAs that target NUSAP1:
    hsa-let-7b-5p (MIRT052111)

    Block miRNA regulation of human, mouse, rat NUSAP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NUSAP1:
    hsa-miR-587
    SwitchGear 3'UTR luciferase reporter plasmidNUSAP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NUSAP1
    Predesigned siRNA for gene silencing in human, mouse, rat NUSAP1

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    GenScript: all cDNA clones in your preferred vector (see all 3): NUSAP1 (NM_018454)
    Sino Biological Human cDNA Clone for NUSAP1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUSAP_HUMAN, Q9BXS6: Cytoplasm (By similarity). Nucleus, nucleolus (By similarity). Cytoplasm, cytoskeleton,
    spindle (By similarity). Chromosome (By similarity). Note=Found in the cytoplasm and nucleolus during interphase
    and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during
    anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes
    to multiple distinct regions of chromosomes throughout mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005819spindle ----

    Find genes that share ontologies with NUSAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUSAP1
    Interactions:

        Search GeneGlobe Interaction Network for NUSAP1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for NUSAP1 (Q9BXS63 ENSP000002603594) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KHDRBS2Q5VWX13, ENSP000002811564I2D: score=1 STRING: ENSP00000281156
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000070mitotic sister chromatid segregation IDA12963707
    GO:0000281mitotic cytokinesis IDA12963707
    GO:0007076mitotic chromosome condensation IDA12963707
    GO:0040001establishment of mitotic spindle localization IDA12963707
    GO:0045840positive regulation of mitosis IDA12963707

    Find genes that share ontologies with NUSAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUSAP1 (NUSAP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUSAP1 gene (6 alternative transcripts): 
    NM_001129897.1  NM_001243142.1  NM_001243143.1  NM_001243144.1  NM_016359.4  NM_018454.7  

    Unigene Cluster for NUSAP1:

    Nucleolar and spindle associated protein 1
    Hs.615092  [show with all ESTs]
    Unigene Representative Sequence: NM_016359
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558123 ENST00000260359(uc001znr.4 uc001zns.4 uc001znt.4 uc001znv.4 uc001znu.4)
    ENST00000559046 ENST00000450592 ENST00000559596 ENST00000414849 ENST00000558582
    ENST00000560747 ENST00000559659 ENST00000560177(uc001znw.4) ENST00000557840
    ENST00000560898 ENST00000560318 ENST00000450318(uc010ucw.2 uc010bce.3)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate NUSAP1:
    hsa-miR-587
    SwitchGear 3'UTR luciferase reporter plasmidNUSAP1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUSAP1
      QuantiTect SYBR Green Assays in human, mouse, rat NUSAP1
      QuantiFast Probe-based Assays in human, mouse, rat NUSAP1

    Additional mRNA sequence: 

    AF090915.1 AF217513.1 AF290612.1 AF305711.1 AK023483.1 AK222819.1 AK225703.1 AK290879.1 
    AK293168.1 AK307728.1 AL833611.1 BC001308.1 BC010838.1 BC011008.1 BC012887.1 BC024772.1 

    20 DOTS entries:

    DT.116010  DT.95330776  DT.97859449  DT.92342790  DT.91860885  DT.121026182  DT.121026205  DT.121026183 
    DT.92449985  DT.100801818  DT.95069470  DT.100037719  DT.100758033  DT.95069475  DT.121026193  DT.92449984 
    DT.121026172  DT.121026179  DT.91829098  DT.92053676 

    Selected AceView cDNA sequences (see all 320):

    BX100702 BP366020 BM789693 AI468649 CA487262 BC001308 NM_018454 AA761698 
    CB164558 BE887489 AI298472 AK023483 CA412518 BC024772 BM460240 CR596878 
    BM785908 BI253832 BM839589 CR591711 BX375925 AF290612 BG939815 BM903806 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUSAP1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                -                                   -     -                                             
    SP2:                                -                                   -     -                                             
    SP3:                                -                                   -     -                                             
    SP4:                                -                                   -     -                                             
    SP5:                                -     -                             -     -                                             


    ECgene alternative splicing isoforms for NUSAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUSAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTGCCAT
    NUSAP1 Expression
    About this image


    NUSAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Double Negative 2 Thymocytes Thymus
             Bone marrow-derived hematopoietic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    NUSAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUSAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.615092
        Custom PCR Arrays for NUSAP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUSAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NUSAP1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nusap11 , 5 nucleolar and spindle associated protein 11, 5 77.29(n)1
    67.4(a)1
      2 (59.97 cM)5
    1089071  NM_133851.31  NP_598612.11 
     1196182985 
    chicken
    (Gallus gallus)
    Aves NUSAP11 nucleolar and spindle associated protein 1 57.08(n)
    48.11(a)
      423213  NM_001031193.1  NP_001026364.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUSAP16
    nucleolar and spindle associated protein 1
    37(a)
    1 ↔ 1
    1(41737496-41752994)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240262 Xenopus laevis transcribed sequence with weak similarity more 75.27(n)    BI477686.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nusap11 nucleolar and spindle associated protein 1 49.92(n)
    43.03(a)
      567446  NM_001145694.1  NP_001139166.1 


    ENSEMBL Gene Tree for NUSAP1 (if available)
    TreeFam Gene Tree for NUSAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUSAP1 gene
    11 SIMAP similar genes for NUSAP1 using alignment to 5 protein entries:     NUSAP_HUMAN (see all proteins):
    COX7A2    DRG2    IFT122    ZNF738    MYO15B    NSRP1
    DAPK2    MTA3    ZNF568    IPO7    TMEM67

    Find genes that share paralogs with NUSAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUSAP1 (see all 897)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30346111,2
    C--41626903(+) CTGGC-/TGTGTGT 5 -- int10--------
    rs1910316581,2
    --41626993(+) CTCCCA/GCCACG 5 -- int10--------
    rs734049721,2
    C--41626997(+) CGCCAC/TGGCCT 5 -- int11Minor allele frequency- T:0.50WA 2
    rs1446146711,2
    --41627035(+) CCCACC/GACGCC 5 -- int10--------
    rs1816645371,2
    C--41627256(+) AATAAA/GATGTT 5 -- int10--------
    rs348428861,2
    C--41627471(+) ACTAT-/TATT  
            
    ATATA
    5 -- int10--------
    rs591076121,2
    C--41627473(+) TATAT-/TTAT  
            
    ATATT
    5 -- int10--------
    rs599722341,2
    C--41627559(+) AAAAT-/AAAC  
            
    TAAAT
    5 -- int10--------
    rs116313961,2
    H--41627609(+) aatatA/Cctata 5 -- int10--------
    rs1484453851,2
    --41627680(+) ATTTAG/TTGTGT 5 -- int10--------

    HapMap Linkage Disequilibrium report for NUSAP1 (41624892 - 41673248 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NUSAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671704CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUSAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for NUSAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612818    OMIM disorders: --


    Find genes that share disorders with NUSAP1           About GenesLikeMe


    Export disorders for NUSAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUSAP1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with NUSAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. (PubMed id 12963707)1, 2, 3 Raemaekers T.... Carmeliet G. (J. Cell Biol. 2003)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer. (PubMed id 23405241)1 Espinosa A.M....Berumen J. (PLoS ONE 2013)
    4. Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1. (PubMed id 22349817)1 Gulzar Z.G....Brooks J.D. (Oncogene 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. ATM-mediated NuSAP phosphorylation induces mitotic arrest. (PubMed id 21130744)2 Xie P.... Zhang L. (Biochem. Biophys. Res. Commun. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51203 HGNC: 18538 AceView: NUSAP1 Ensembl:ENSG00000137804 euGenes: HUgn51203
    ECgene: NUSAP1 H-InvDB: NUSAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUSAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NUSAP1 gene:
    Search GeneIP for patents involving NUSAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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