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Aliases for NUSAP1 Gene

Aliases for NUSAP1 Gene

  • Nucleolar And Spindle Associated Protein 1 2 3
  • NUSAP 3 4 6
  • ANKT 3 4 6
  • Nucleolar And Spindle-Associated Protein 1 3
  • Nucleolar Protein ANKT 3
  • PRO0310p1 3
  • BM037 3
  • Q0310 3
  • SAPL 3
  • LNP 3

External Ids for NUSAP1 Gene

Summaries for NUSAP1 Gene

Entrez Gene Summary for NUSAP1 Gene

  • NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

GeneCards Summary for NUSAP1 Gene

NUSAP1 (Nucleolar And Spindle Associated Protein 1) is a Protein Coding gene. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for NUSAP1 Gene

  • Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUSAP1 Gene

Genomics for NUSAP1 Gene

Genomic Location for NUSAP1 Gene

Start:
41,332,694 bp from pter
End:
41,381,050 bp from pter
Size:
48,357 bases
Orientation:
Plus strand

Genomic View for NUSAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUSAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUSAP1 Gene

Regulatory Elements for NUSAP1 Gene

Proteins for NUSAP1 Gene

  • Protein details for NUSAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXS6-NUSAP_HUMAN
    Recommended name:
    Nucleolar and spindle-associated protein 1
    Protein Accession:
    Q9BXS6
    Secondary Accessions:
    • B4DDF1
    • E7ERR5
    • J3KN21
    • Q53GW2
    • Q8TBT4
    • Q96E58
    • Q96FJ1
    • Q9GZM9
    • Q9NZ85
    • Q9UI70

    Protein attributes for NUSAP1 Gene

    Size:
    441 amino acids
    Molecular mass:
    49452 Da
    Quaternary structure:
    • Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2 (By similarity).
    SequenceCaution:
    • Sequence=AAF24034.1; Type=Frameshift; Positions=205; Evidence={ECO:0000305}; Sequence=AAF67624.1; Type=Frameshift; Positions=175, 205; Evidence={ECO:0000305}; Sequence=AAH12887.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUSAP1 Gene

neXtProt entry for NUSAP1 Gene

Proteomics data for NUSAP1 Gene at MOPED

Post-translational modifications for NUSAP1 Gene

  • Phosphorylation by ATM in G2/M-phase induces mitotic arrest.
  • Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUSAP1 Gene

Domains for NUSAP1 Gene

Protein Domains for NUSAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUSAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXS6

UniProtKB/Swiss-Prot:

NUSAP_HUMAN
Domain:
  • The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination:
    • Q9BXS6
Family:
  • Belongs to the NUSAP family.:
    • Q9BXS6
genes like me logo Genes that share domains with NUSAP1: view

No data available for Gene Families for NUSAP1 Gene

Function for NUSAP1 Gene

Molecular function for NUSAP1 Gene

UniProtKB/Swiss-Prot Function: Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.

Gene Ontology (GO) - Molecular Function for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NUSAP1: view
genes like me logo Genes that share phenotypes with NUSAP1: view

Animal Models for NUSAP1 Gene

MGI Knock Outs for NUSAP1:

miRNA for NUSAP1 Gene

miRTarBase miRNAs that target NUSAP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NUSAP1 Gene

Localization for NUSAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUSAP1 Gene

Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome. Note=Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis. {ECO:0000250, ECO:0000269 PubMed:17276916, ECO:0000269 PubMed:17618083}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUSAP1 Gene COMPARTMENTS Subcellular localization image for NUSAP1 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005819 spindle --
genes like me logo Genes that share ontologies with NUSAP1: view

Pathways for NUSAP1 Gene

SuperPathways for NUSAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IDA 12963707
GO:0000281 mitotic cytokinesis IDA 12963707
GO:0007076 mitotic chromosome condensation IDA 12963707
GO:0040001 establishment of mitotic spindle localization IDA 12963707
GO:0045840 positive regulation of mitotic nuclear division IDA 12963707
genes like me logo Genes that share ontologies with NUSAP1: view

No data available for Pathways by source for NUSAP1 Gene

Transcripts for NUSAP1 Gene

Unigene Clusters for NUSAP1 Gene

Nucleolar and spindle associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUSAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - - -
SP9: -
SP10:
SP11: - - -
SP12:

Relevant External Links for NUSAP1 Gene

GeneLoc Exon Structure for
NUSAP1
ECgene alternative splicing isoforms for
NUSAP1

Expression for NUSAP1 Gene

mRNA expression in normal human tissues for NUSAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUSAP1 Gene

SOURCE GeneReport for Unigene cluster for NUSAP1 Gene Hs.615092

genes like me logo Genes that share expressions with NUSAP1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUSAP1 Gene

Orthologs for NUSAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUSAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUSAP1 35
  • 99.24 (n)
  • 98.64 (a)
NUSAP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUSAP1 35
  • 85.2 (n)
  • 77.8 (a)
NUSAP1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUSAP1 35
  • 84.06 (n)
  • 76.2 (a)
NUSAP1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nusap1 35
  • 77.29 (n)
  • 67.4 (a)
Nusap1 16
Nusap1 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUSAP1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUSAP1 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nusap1 35
  • 76.32 (n)
  • 65.03 (a)
chicken
(Gallus gallus)
Aves NUSAP1 35
  • 57.08 (n)
  • 48.11 (a)
NUSAP1 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUSAP1 36
  • 37 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24026 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nusap1 35
  • 55.99 (n)
  • 50 (a)
Str.367 35
zebrafish
(Danio rerio)
Actinopterygii nusap1 35
  • 49.92 (n)
  • 43.03 (a)
nusap1 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for NUSAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUSAP1 Gene

ENSEMBL:
Gene Tree for NUSAP1 (if available)
TreeFam:
Gene Tree for NUSAP1 (if available)

Paralogs for NUSAP1 Gene

Selected SIMAP similar genes for NUSAP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUSAP1: view

No data available for Paralogs for NUSAP1 Gene

Variants for NUSAP1 Gene

Sequence variations from dbSNP and Humsavar for NUSAP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs919961 -- 41,359,523(+) GATAA(A/G)TTGTA intron-variant
rs2015781 -- 41,356,769(+) TGAAT(C/G)AATGT intron-variant
rs3034611 -- 41,334,705(+) CTGGC(-/TG)TGTGT intron-variant
rs4368143 -- 41,363,237(+) gccaa(G/T)atcac intron-variant
rs4580125 -- 41,363,339(+) TCTCt(A/C)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUSAP1 Gene

Variant ID Type Subtype PubMed ID
esv2671704 CNV Deletion 23128226

Relevant External Links for NUSAP1 Gene

HapMap Linkage Disequilibrium report
NUSAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUSAP1 Gene

Disorders for NUSAP1 Gene

No disorders were found for NUSAP1 Gene.

No data available for UniProtKB/Swiss-Prot for NUSAP1 Gene

Publications for NUSAP1 Gene

  1. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. (PMID: 12963707) Raemaekers T. … Carmeliet G. (J. Cell Biol. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3

Products for NUSAP1 Gene

Sources for NUSAP1 Gene

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