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Aliases for NUSAP1 Gene

Aliases for NUSAP1 Gene

  • Nucleolar And Spindle Associated Protein 1 2 3 5
  • NUSAP 3 4
  • ANKT 3 4
  • Nucleolar And Spindle-Associated Protein 1 3
  • Nucleolar Protein ANKT 3
  • PRO0310p1 3
  • BM037 3
  • Q0310 3
  • SAPL 3
  • LNP 3

External Ids for NUSAP1 Gene

Previous GeneCards Identifiers for NUSAP1 Gene

  • GC15P039341
  • GC15P039412
  • GC15P041624
  • GC15P018473

Summaries for NUSAP1 Gene

Entrez Gene Summary for NUSAP1 Gene

  • NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

GeneCards Summary for NUSAP1 Gene

NUSAP1 (Nucleolar And Spindle Associated Protein 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and microtubule binding.

UniProtKB/Swiss-Prot for NUSAP1 Gene

  • Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUSAP1 Gene

Genomics for NUSAP1 Gene

Regulatory Elements for NUSAP1 Gene

Enhancers for NUSAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NUSAP1 on UCSC Golden Path with GeneCards custom track

Promoters for NUSAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NUSAP1 Gene

Chromosome:
15
Start:
41,332,694 bp from pter
End:
41,381,050 bp from pter
Size:
48,357 bases
Orientation:
Plus strand

Genomic View for NUSAP1 Gene

Genes around NUSAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUSAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUSAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUSAP1 Gene

Proteins for NUSAP1 Gene

  • Protein details for NUSAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXS6-NUSAP_HUMAN
    Recommended name:
    Nucleolar and spindle-associated protein 1
    Protein Accession:
    Q9BXS6
    Secondary Accessions:
    • B4DDF1
    • E7ERR5
    • J3KN21
    • Q53GW2
    • Q8TBT4
    • Q96E58
    • Q96FJ1
    • Q9GZM9
    • Q9NZ85
    • Q9UI70

    Protein attributes for NUSAP1 Gene

    Size:
    441 amino acids
    Molecular mass:
    49452 Da
    Quaternary structure:
    • Interacts with DNA and microtubules. Microtubule bundling is inhibited by IPO7, KPNA2 and KPNB1 while association with DNA is also inhibited by IPO7 and KPNA2 (By similarity).
    SequenceCaution:
    • Sequence=AAF24034.1; Type=Frameshift; Positions=205; Evidence={ECO:0000305}; Sequence=AAF67624.1; Type=Frameshift; Positions=175, 205; Evidence={ECO:0000305}; Sequence=AAH12887.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NUSAP1 Gene

neXtProt entry for NUSAP1 Gene

Post-translational modifications for NUSAP1 Gene

  • Phosphorylation by ATM in G2/M-phase induces mitotic arrest.
  • Ubiquitinated. Ubiquitination by FZR1 may lead to proteasome-dependent degradation of this protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NUSAP1 Gene

Domains & Families for NUSAP1 Gene

Protein Domains for NUSAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUSAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXS6

UniProtKB/Swiss-Prot:

NUSAP_HUMAN :
  • The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.
  • Belongs to the NUSAP family.
Domain:
  • The KEN box is required for the FZR1-dependent degradation of this protein subsequent to ubiquitination.
Family:
  • Belongs to the NUSAP family.
genes like me logo Genes that share domains with NUSAP1: view

No data available for Gene Families for NUSAP1 Gene

Function for NUSAP1 Gene

Molecular function for NUSAP1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the organization of mitotic spindle microtubules around them.

Gene Ontology (GO) - Molecular Function for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NUSAP1: view
genes like me logo Genes that share phenotypes with NUSAP1: view

Animal Models for NUSAP1 Gene

MGI Knock Outs for NUSAP1:

Animal Model Products

CRISPR Products

miRNA for NUSAP1 Gene

miRTarBase miRNAs that target NUSAP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUSAP1 Gene

Localization for NUSAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUSAP1 Gene

Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Chromosome. Note=Found in the cytoplasm and nucleolus during interphase and redistributes to the mitotic spindle in prometaphase (By similarity). Localizes to the mitotic spindle during anaphase and telophase then disappears from around the chromosomes during cytokinesis (By similarity). Localizes to multiple distinct regions of chromosomes throughout mitosis. {ECO:0000250, ECO:0000269 PubMed:17276916, ECO:0000269 PubMed:17618083}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUSAP1 Gene COMPARTMENTS Subcellular localization image for NUSAP1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005876 spindle microtubule IEA --
genes like me logo Genes that share ontologies with NUSAP1: view

Pathways & Interactions for NUSAP1 Gene

SuperPathways for NUSAP1 Gene

No Data Available

SIGNOR curated interactions for NUSAP1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NUSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IDA 12963707
GO:0000281 mitotic cytokinesis IDA 12963707
GO:0007076 mitotic chromosome condensation IDA 12963707
GO:0040001 establishment of mitotic spindle localization IDA 12963707
GO:0045840 positive regulation of mitotic nuclear division IDA 12963707
genes like me logo Genes that share ontologies with NUSAP1: view

No data available for Pathways by source for NUSAP1 Gene

Drugs & Compounds for NUSAP1 Gene

No Compound Related Data Available

Transcripts for NUSAP1 Gene

Unigene Clusters for NUSAP1 Gene

Nucleolar and spindle associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUSAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - - -
SP9: -
SP10:
SP11: - - -
SP12:

Relevant External Links for NUSAP1 Gene

GeneLoc Exon Structure for
NUSAP1
ECgene alternative splicing isoforms for
NUSAP1

Expression for NUSAP1 Gene

mRNA expression in normal human tissues for NUSAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUSAP1 Gene

This gene is overexpressed in Amniocyte (42.2) and Lung (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUSAP1 Gene



Protein tissue co-expression partners for NUSAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUSAP1 Gene:

NUSAP1

SOURCE GeneReport for Unigene cluster for NUSAP1 Gene:

Hs.615092
genes like me logo Genes that share expression patterns with NUSAP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUSAP1 Gene

Orthologs for NUSAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUSAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUSAP1 34
  • 85.2 (n)
  • 77.8 (a)
NUSAP1 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUSAP1 34
  • 84.06 (n)
  • 76.2 (a)
NUSAP1 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nusap1 34
  • 77.29 (n)
  • 67.4 (a)
Nusap1 16
Nusap1 35
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUSAP1 34
  • 99.24 (n)
  • 98.64 (a)
NUSAP1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nusap1 34
  • 76.32 (n)
  • 65.03 (a)
oppossum
(Monodelphis domestica)
Mammalia NUSAP1 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUSAP1 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUSAP1 34
  • 57.08 (n)
  • 48.11 (a)
NUSAP1 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUSAP1 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nusap1 34
  • 55.99 (n)
  • 50 (a)
Str.367 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24026 34
zebrafish
(Danio rerio)
Actinopterygii nusap1 34
  • 49.92 (n)
  • 43.03 (a)
nusap1 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToOne
Species where no ortholog for NUSAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUSAP1 Gene

ENSEMBL:
Gene Tree for NUSAP1 (if available)
TreeFam:
Gene Tree for NUSAP1 (if available)

Paralogs for NUSAP1 Gene

(11) SIMAP similar genes for NUSAP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUSAP1: view

No data available for Paralogs for NUSAP1 Gene

Variants for NUSAP1 Gene

Sequence variations from dbSNP and Humsavar for NUSAP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs7178634 - 41,342,389(+) AGGCA(A/G)CCAAG intron-variant, reference, missense
rs7178777 - 41,342,390(+) GGCAA(A/C)CAAGT intron-variant, reference, missense
rs4368143 -- 41,363,237(+) gccaa(G/T)atcac intron-variant
rs4580125 -- 41,363,339(+) TCTCt(A/C)tatat intron-variant
rs4636885 -- 41,369,695(+) CACTG(A/C)AATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUSAP1 Gene

Variant ID Type Subtype PubMed ID
dgv2580n100 CNV gain 25217958
esv2671704 CNV deletion 23128226
nsv1039283 CNV gain 25217958
nsv1134434 CNV deletion 24896259

Variation tolerance for NUSAP1 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.84; 96.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUSAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUSAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUSAP1 Gene

Disorders for NUSAP1 Gene

Relevant External Links for NUSAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUSAP1

No disorders were found for NUSAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUSAP1 Gene

Publications for NUSAP1 Gene

  1. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. (PMID: 12963707) Raemaekers T. … Carmeliet G. (J. Cell Biol. 2003) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force. (PMID: 26839278) Li C. … Liou Y.C. (Nat Commun 2016) 3 65
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for NUSAP1 Gene

Sources for NUSAP1 Gene

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