Aliases for NUS1 Gene
External Ids for NUS1 Gene
Previous HGNC Symbols for NUS1 Gene
Previous GeneCards Identifiers for NUS1 Gene
GeneCards Summary for NUS1 Gene
NUS1 (Nuclear Undecaprenyl Pyrophosphate Synthase 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring alkyl or aryl (other than methyl) groups.
UniProtKB/Swiss-Prot for NUS1 Gene
With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.