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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUS1 Gene

protein-coding   GIFtS: 47
GCID: GC06P117997

Nuclear Undecaprenyl Pyrophosphate Synthase 1 Homolog (S....

(Previous name: chromosome 6 open reading frame 68)
(Previous symbol: C6orf68)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Undecaprenyl Pyrophosphate Synthase 1 Homolog (S.
Cerevisiae)1 2
     Transport And Golgi Organization 14 Homolog (Drosophila)1
C6orf681 2 3 5     MGC:71992
Nogo-B Receptor1 2     TANGO142
NgBR2 3     Transport And Golgi Organization 14 Homolog2
NGBR3 5     Nuclear Undecaprenyl Pyrophosphate Synthase 1 Homolog3
Chromosome 6 Open Reading Frame 681     

External Ids:    HGNC: 210421   Entrez Gene: 1161502   Ensembl: ENSG000001539897   OMIM: 6104635   UniProtKB: Q96E223   

Export aliases for NUS1 gene to outside databases

Previous GC identifers: GC06P118104 GC06P115577


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NUS1 Gene: 
NUS1 (nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with NUS1 include citrullinemia, and inclusion body myositis. GO annotations related to this gene include molecular_function and transferase activity, transferring alkyl or aryl (other than methyl) groups.

UniProtKB/Swiss-Prot: NGBR_HUMAN, Q96E22
Function: Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.
Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol
Function: Essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUS1 gene promoter:
         MEF-2A   STAT1   Pax-5   AML1a   MEF-2   STAT1beta   aMEF-2   STAT1alpha   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q22.1   HGNC cytogenetic band: 6q22.1

NUS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUS1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P117997:  view genomic region     (about GC identifiers)

Start:
117,996,617 bp from pter      End:
118,031,890 bp from pter
Size:
35,274 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NGBR_HUMAN, Q96E22 (See protein sequence)
Recommended Name: Nogo-B receptor precursor  
Size: 293 amino acids; 33224 Da
Subunit: Interacts with DHDDS, promoting its isoprenyltransferase activity. Interacts with NPC2
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Colocalizes with
Nogo-B during VEGF and wound healing angiogenesis
Miscellaneous: Although strongly related to UPP synthase family proteins, it has no lipid transferase activity
Miscellaneous: NUS1 seems to exist in two topological orientations, a minor glycosylated species with its
C-terminus oriented towards the lumen regulating NPC2 stability, and a major fraction oriented with its
C-terminus directed towards the cytosol where it regulates cis-IPTase activity
Sequence caution: Sequence=AAB72234.1; Type=Frameshift; Positions=Several;
Secondary accessions: B2RWQ4 O00251

Explore the universe of human proteins at neXtProt for NUS1: NX_Q96E22

Explore proteomics data for NUS1 at MOPED 

NUS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

NUS1 Protein Expression

REFSEQ proteins: NP_612468.1  
ENSEMBL proteins: 
 ENSP00000357480  

Human Recombinant Protein Products for NUS1: 
Browse Purified and Recombinant Proteins at EMD Millipore
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OriGene Protein Over-expression Lysate for NUS1
OriGene Custom MassSpec 
OriGene Custom Protein Services for NUS1
GenScript Custom Purified and Recombinant Proteins Services for NUS1
Novus Biologicals NUS1 Protein
Novus Biologicals NUS1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for NUS1 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005789endoplasmic reticulum membrane IDA19723497
GO:0016021integral to membrane IEA--

NUS1 for ontologies           About GeneDecksing



NUS1 Antibody Products: 
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OriGene Custom Antibody Services for NUS1
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Novus Biologicals NUS1 Antibody
Abcam antibodies for NUS1
Cloud-Clone Corp. Antibodies for NUS1 
Search ThermoFisher Antibodies for NUS1
LSBio Antibodies in human, mouse, rat for NUS1 

Assay Products for NUS1: 
Browse Kits and Assays available from EMD Millipore
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GenScript Custom Assay Services for NUS1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for NUS1 
Cloud-Clone Corp. CLIAs for NUS1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR001441 UPP_synth-like

Graphical View of Domain Structure for InterPro Entry Q96E22

ProtoNet protein and cluster: Q96E22

UniProtKB/Swiss-Prot: NGBR_HUMAN, Q96E22
Similarity: Belongs to the UPP synthase family


NUS1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NGBR_HUMAN, Q96E22
Function: Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator.
Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol
Function: Essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0005515protein binding IPI--
GO:0016765transferase activity, transferring alkyl or aryl (other than methyl) groups IEA--
     
NUS1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for NUS1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUS1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUS1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUS1 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUS1
8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate NUS1 (see all 87):
hsa-miR-548j hsa-miR-607 hsa-miR-642a hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-502-3p hsa-miR-3161
SwitchGear 3'UTR luciferase reporter plasmidNUS1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for NUS1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUS1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for NUS1
Sirion Biotech Customized adenovirus for overexpression of NUS1

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for NUS1 (see all 7)
OriGene ORF clones in mouse, rat for NUS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for NUS1
Sino Biological Human cDNA Clone for NUS1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUS1
Sirion Biotech Customized lentivirus for stable overexpression of NUS1 
                     Customized lentivirus expression plasmids for stable overexpression of NUS1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for NUS1
Search LifeMap BioReagents cell lines for NUS1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUS1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




UniProtKB/Swiss-Prot: NGBR_HUMAN, Q96E22
Pathway: Protein modification; protein glycosylation

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUS1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for NUS1 (Q96E222, 3 ENSP000003574804) via UniProtKB, MINT, STRING, and/or I2D

InteractantInteraction Details
GeneCardExternal ID(s)
C10orf95Q9H7T32, 3, ENSP000002391254MINT-8289895 MINT-8289909 MINT-8189187 I2D: score=1 STRING: ENSP00000239125
About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001525angiogenesis IEA--
GO:0006486protein glycosylation IEA--
GO:0008150biological_process ND--
GO:0030154cell differentiation IEA--
GO:0032367intracellular cholesterol transport IGI19723497

NUS1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUS1 (NGBR)

1 HMDB Compound for NUS1    About this table
CompoundSynonyms CAS #PubMed Ids
Undecaprenyl diphosphateDiphosphoric acid mono(3,7,11,15,19,23,27,31,35,39,43-undecamethyl-2,6,10,14,18,22,26,30,34,38,42-tetratetracontaundecaenyl) ester (see all 8)23-13-2--

Search CenterWatch for drugs/clinical trials and news about NUS1 / NGBR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NUS1 gene: 
NM_138459.3  

Unigene Cluster for NUS1:

Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
Hs.289008  [show with all ESTs]
Unigene Representative Sequence: NM_138459
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000368494(uc003pxw.3)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUS1
8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate NUS1 (see all 87):
hsa-miR-548j hsa-miR-607 hsa-miR-642a hsa-miR-485-3p hsa-miR-128 hsa-miR-30d hsa-miR-502-3p hsa-miR-3161
SwitchGear 3'UTR luciferase reporter plasmidNUS1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for NUS1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUS1
Clone
Products:
     
OriGene clones in human, mouse for NUS1 (see all 7)
OriGene ORF clones in mouse, rat for NUS1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for NUS1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUS1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUS1
Sirion Biotech Customized lentivirus for stable overexpression of NUS1 
                     Customized lentivirus expression plasmids for stable overexpression of NUS1 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for NUS1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUS1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUS1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUS1

Additional mRNA sequence: 

AJ420576.1 AK025467.1 AK125119.1 AK126335.1 AK130093.1 BC013026.2 BC063794.1 BC066910.1 
BC110325.1 BC150654.1 BC150655.1 

17 DOTS entries:

DT.40113899  DT.100807626  DT.121280600  DT.121359116  DT.121283823  DT.95111091  DT.100653672  DT.102832393 
DT.95194164  DT.102832392  DT.100001462  DT.100653673  DT.100653675  DT.101986978  DT.121359111  DT.92435632 
DT.92435633 

24/270 AceView cDNA sequences (see all 270):

BG289236 BF594373 CB162690 BQ917949 AA854659 BM684534 AA634601 AI478725 
AI691017 AA256683 AI472334 H26324 AA287318 AI040733 AI453072 AI347373 
BM756379 BQ007086 AK126335 AA694475 BF112132 CA413953 BC066910 AA587659 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NUS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATGAACAAA
NUS1 Expression
About this image


See NUS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUS1

SOURCE GeneReport for Unigene cluster: Hs.289008
    SABiosciences Expression via Pathway-Focused PCR Array including NUS1: 
          Hepatotoxicity in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for NUS1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUS1
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUS1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUS1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUS1 gene from 7/15 species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nus11 , 5 nuclear undecaprenyl pyrophosphate synthase 1 homolog more1, 5 89.99(n)1
90.44(a)1
  10 (26.64 cM)5
520141  NM_030250.21  NP_084526.11 
 524175475 
chicken
(Gallus gallus)
Aves NUS11 nuclear undecaprenyl pyrophosphate synthase 1 homolog more 75.55(n)
71.53(a)
  421733  XM_419766.3  XP_419766.3 
lizard
(Anolis carolinensis)
Reptilia NUS16
Uncharacterized protein
62(a)
1 ↔ 1
1(185467044-185488446)
African clawed frog
(Xenopus laevis)
Amphibia Xl.130982 Xenopus laevis transcribed sequence with weak similarity more 77.22(n)    BJ089354.1 
zebrafish
(Danio rerio)
Actinopterygii nus11 nuclear undecaprenyl pyrophosphate synthase 1 homolog more 63.47(n)
60.52(a)
  436629  NM_001002356.1  NP_001002356.1 
fruit fly
(Drosophila melanogaster)
Insecta Tango146
Transport and Golgi organization 14
28(a)
1 ↔ 1
2L(1158661-1160220)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NUS1(YDL193W)4 Putative prenyltransferase, required for cell viability; more   --   4(114672-115799) 851334  NP_010088.1 


ENSEMBL Gene Tree for NUS1 (if available)
TreeFam Gene Tree for NUS1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NUS1 gene

NUS1 for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for NUS1
PGOHUM00000248473 PGOHUM00000248526 PGOHUM00000248533 PGOHUM00000241883


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/724 SNPs in NUS1 are shown (see all 724)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0300964
----see VAR_0300962 T K mis40--------
rs1887917841,2
--117994708(+) CCCGCC/TTCTAC 1 -- us2k10--------
rs1815489871,2
--117994793(+) GAGAAC/TGGCGT 1 -- us2k10--------
rs2019845371,2
C--117994837(+) ATCGCA/GCCACT 1 -- us2k10--------
rs568020711,2
C,F--117994867(+) TGAGCG/AAGACT 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1907290601,2
--117994991(+) GGATAA/GACATT 1 -- us2k10--------
rs97666561,2
C,F,A,H--117995199(+) CTTTCG/TCCTCT 1 -- us2k1 tfbs36Minor allele frequency- T:0.09NS EA WA NA 654
rs1822172211,2
--117995247(+) AGACCA/TGGAGA 1 -- us2k10--------
rs1483240291,2
--117995328(+) AAAATG/TGCACT 1 -- us2k10--------
rs117548781,2
C,F,H--117995353(+) GACATG/AAGATT 1 -- us2k13Minor allele frequency- A:0.07WA NA EA 358

HapMap Linkage Disequilibrium report for NUS1 (117996617 - 118031890 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for NUS1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv5449CNV Loss18451855
nsv830786CNV Gain17160897

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing NUS1
DNA2.0 Custom Variant and Variant Library Synthesis for NUS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 610463    OMIM disorders: --

4 diseases for NUS1:    About MalaCards
citrullinemia    inclusion body myositis    myositis    endotheliitis


NUS1 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: NUS1 (1 document)

Export disorders for NUS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NUS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NUS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Nogo-B receptor is necessary for cellular dolichol bi osynthesis and protein N-glycosylation. (PubMed id 21572394)1, 2 Harrison K.D....Sessa W.C. (2011)
  2. Nogo-B receptor stabilizes Niemann-Pick type C2 prote in and regulates intracellular cholesterol trafficking. (PubMed id 19723497)1, 2 Harrison K.D....Sessa W.C. (2009)
  3. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. (PubMed id 16835300)1, 2 Miao R.Q.... Sessa W.C. (2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  6. Direct isolation of human transcribed sequences from yeast artificial chromosomes through the application of RNA fingerprinting. (PubMed id 9294218)1, 2 Still I.H.... Cowell J.K. (1997)
  7. NOGO is increased and binds to BACE1 in sporadic inclusion-body myositis and in A beta PP-overexpressing cultured human muscle fibers. (PubMed id 17764014)1 Wojcik S....Askanas V. (2007)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 116150 HGNC: 21042 AceView: C6orf68 Ensembl:ENSG00000153989 euGenes: HUgn116150
ECgene: NUS1 H-InvDB: NUS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for NUS1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NUS1 gene:
Search GeneIP for patents involving NUS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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