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Aliases for NUPR2 Gene

Aliases for NUPR2 Gene

  • Nuclear Protein 2, Transcriptional Regulator 2 3 5
  • Nuclear Transcriptional Regulator 1-Like Protein 3 4
  • Nuclear Transcriptional Regulator Protein 2 3 4
  • NUPR1L 3 4
  • Nuclear Protein, Transcriptional Regulator, 1-Like 3
  • Nuclear Protein, Transcriptional Regulator 1 Like 2
  • Nuclear Protein 2 3

External Ids for NUPR2 Gene

Previous HGNC Symbols for NUPR2 Gene

  • NUPR1L

Summaries for NUPR2 Gene

GeneCards Summary for NUPR2 Gene

NUPR2 (Nuclear Protein 2, Transcriptional Regulator) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NUPR2 Gene

  • Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells (PubMed:25899918). Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation (PubMed:25899918). Plays a role as a negative regulator of the protumoral factor NUPR1 (PubMed:25899918).

Additional gene information for NUPR2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUPR2 Gene

Genomics for NUPR2 Gene

GeneHancer (GH) Regulatory Elements for NUPR2 Gene

Promoters and enhancers for NUPR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I056115 Promoter/Enhancer 0.8 EPDnew ENCODE 550.8 +0.1 102 0.8 CTCF NUPR2 NIPSNAP2 PIR43445
GH07I056483 Enhancer 0.3 FANTOM5 49.4 -367.6 -367564 0.1 LOC100240728 NUPR2 RBM22P3
GH07I056004 Enhancer 1.2 Ensembl ENCODE 5.4 +108.7 108694 6.8 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 ETS1 TCF12 SLC30A9 NIPSNAP2 SUMF2 CCT6A PHKG1 LOC154937 MRPS17 PSPHP1 ZNF713 NUPR2 PIR39528
GH07I056175 Enhancer 0.4 FANTOM5 12.5 -59.6 -59564 0.3 SUZ12 LOC100130909 GC07P056175 NUPR2 CCNJP1
GH07I056538 Enhancer 0.2 FANTOM5 2.8 -422.3 -422337 0.1 LOC101928401 CHCHD2 NUPR2 VN1R25P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUPR2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NUPR2 Gene

Genomic Locations for NUPR2 Gene
chr7:56,114,681-56,116,400
(GRCh38/hg38)
Size:
1,720 bases
Orientation:
Minus strand
chr7:56,182,374-56,184,093
(GRCh37/hg19)

Genomic View for NUPR2 Gene

Genes around NUPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUPR2 Gene

Proteins for NUPR2 Gene

  • Protein details for NUPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NF83-NUPR2_HUMAN
    Recommended name:
    Nuclear protein 2
    Protein Accession:
    A6NF83

    Protein attributes for NUPR2 Gene

    Size:
    97 amino acids
    Molecular mass:
    11356 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NUPR2 Gene

Post-translational modifications for NUPR2 Gene

No Post-translational modifications

Other Protein References for NUPR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NUPR2 Gene

Domains & Families for NUPR2 Gene

Gene Families for NUPR2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUPR2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NF83

UniProtKB/Swiss-Prot:

NUPR2_HUMAN :
  • Belongs to the NUPR family.
Family:
  • Belongs to the NUPR family.
genes like me logo Genes that share domains with NUPR2: view

No data available for Suggested Antigen Peptide Sequences for NUPR2 Gene

Function for NUPR2 Gene

Molecular function for NUPR2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells (PubMed:25899918). Involved in the G1 cell cycle arrest, and in a decrease in cell viability and cell proliferation (PubMed:25899918). Plays a role as a negative regulator of the protumoral factor NUPR1 (PubMed:25899918).
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53 in cancer cells (PubMed:25899918). Up-regulated by DNA damage stimulus or starvation (PubMed:25899918).

Gene Ontology (GO) - Molecular Function for NUPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with NUPR2: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NUPR2 Gene

Localization for NUPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUPR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUPR2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for NUPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 25899918
genes like me logo Genes that share ontologies with NUPR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NUPR2 Gene

Pathways & Interactions for NUPR2 Gene

SuperPathways for NUPR2 Gene

No Data Available

Interacting Proteins for NUPR2 Gene

Gene Ontology (GO) - Biological Process for NUPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 25899918
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 25899918
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with NUPR2: view

No data available for Pathways by source and SIGNOR curated interactions for NUPR2 Gene

Drugs & Compounds for NUPR2 Gene

No Compound Related Data Available

Transcripts for NUPR2 Gene

mRNA/cDNA for NUPR2 Gene

(1) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUPR2 Gene

No ASD Table

Relevant External Links for NUPR2 Gene

GeneLoc Exon Structure for
NUPR2
ECgene alternative splicing isoforms for
NUPR2

Expression for NUPR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUPR2 Gene:

NUPR2
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUPR2 Gene

Orthologs for NUPR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NUPR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUPR1L 33
  • 97.59 (n)
mouse
(Mus musculus)
Mammalia Nupr1l 33 16 34
  • 76.04 (n)
rat
(Rattus norvegicus)
Mammalia Nupr1l 33
  • 74.31 (n)
dog
(Canis familiaris)
Mammalia NUPR1L 34
  • 72 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUPR1L 34
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUPR1L 34
  • 55 (a)
OneToOne
Species where no ortholog for NUPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NUPR2 Gene

ENSEMBL:
Gene Tree for NUPR2 (if available)
TreeFam:
Gene Tree for NUPR2 (if available)

Paralogs for NUPR2 Gene

No data available for Paralogs for NUPR2 Gene

Variants for NUPR2 Gene

Sequence variations from dbSNP and Humsavar for NUPR2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000213717 -- 56,115,324(-) A/G intron_variant
rs1001225071 -- 56,114,932(-) A/G intron_variant
rs1002913605 -- 56,116,535(-) C/T upstream_transcript_variant
rs1003565940 -- 56,118,105(-) C/T upstream_transcript_variant
rs1003808604 -- 56,114,572(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NUPR2 Gene

Variant ID Type Subtype PubMed ID
dgv1201e199 CNV deletion 23128226
esv1584077 CNV insertion 17803354
esv2734447 CNV deletion 23290073
esv2734448 CNV deletion 23290073
esv2761334 CNV gain 21179565
esv28230 CNV gain+loss 19812545
esv3576358 CNV gain 25503493
esv3613248 CNV gain 21293372
esv3613258 CNV gain 21293372
esv3613259 CNV gain 21293372
nsv526294 CNV gain 19592680
nsv970839 CNV duplication 23825009

Variation tolerance for NUPR2 Gene

Gene Damage Index Score: 0.85; 17.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUPR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUPR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUPR2 Gene

Disorders for NUPR2 Gene

No disorders were found for NUPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUPR2 Gene

Publications for NUPR2 Gene

  1. Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1. (PMID: 25899918) Lopez MB … Iovanna J (Journal of cellular physiology 2015) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 4 58

Products for NUPR2 Gene

Sources for NUPR2 Gene

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