Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUPR1 Gene

protein-coding   GIFtS: 50
GCID: GC16M028548

nuclear protein, transcriptional regulator, 1
 Explore 16 diseases affiliated with
NUPR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUPR1    

Aliases
for NUPR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nuclear Protein, Transcriptional Regulator, 11 2     P82
COM11 2 3     P82
Candidate Of Metastasis 12 3     Nuclear Protein 12
Protein P82 3     

External Ids:    HGNC: 299901   Entrez Gene: 264712   Ensembl: ENSG000001760467   OMIM: 6148125   UniProtKB: O603563   

Export aliases for NUPR1 gene to outside databases

Previous GC identifers: GC16M028457 GC16M026574


Summaries
for NUPR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NUPR1_HUMAN, O60356
Function: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells
with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its
activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription,
leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal
adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast
cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation
and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as
doxorubicin

Gene Wiki entry for NUPR1


Genomic Views
for NUPR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUPR1 gene promoter:
         Sox5   AP-1   NCX/Ncx   NRSF form 1   Brachyury   HSF1 (long)   NRSF form 2   HEN1   HSF1short   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUPR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUPR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

NUPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUPR1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028548:  view genomic region     (about GC identifiers)

Start:
 28,548,606 bp from pter      End:
 28,550,495 bp from pter
Size:
 1,890 bases      Orientation:
 minus strand

Proteins
for NUPR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NUPR1_HUMAN, O60356 (See protein sequence)
Recommended Name: Nuclear protein 1  
Size: 82 amino acids; 8873 Da
Subunit: Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex;
the interaction with MORF4L1 may be mediated by MSL1
Subcellular location: Nucleus
Sequence caution: Sequence=AAC05335.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R5C4 O60357 Q6FGG3

Explore the universe of human proteins at neXtProt for NUPR1: NX_O60356

Post-translational modifications:

  • Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60356

    • NUPR1 Protein expression data from MOPED and PaxDb:    About this image 
    NUPR1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001035948.1  NP_036517.1  

    ENSEMBL proteins: 
     ENSP00000315559   ENSP00000456597   ENSP00000379003  

    Human Recombinant Protein Products for NUPR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NUPR1
    OriGene Protein Over-expression Lysate: NUPR1
    OriGene Custom Protein Services for NUPR1 
    GenScript Custom Purified and Recombinant Proteins Services for NUPR1
    Novus Biologicals NUPR1 Protein
    Novus Biologicals NUPR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NUPR1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10092851

    NUPR1 for ontologies           About GeneDecksing



    NUPR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NUPR1 
    GenScript Custom Superior Antibodies Services for NUPR1
    Novus Biologicals NUPR1 Antibody
    Abcam antibodies for NUPR1 
    Uscn Antibodies for NUPR1
    Search ThermoFisher Antibodies for NUPR1

    Assay Products for NUPR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUPR1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NUPR1

    Protein Domains /
    Families
    for NUPR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUPR1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR018792 Nuclear_phosphoprot_p8_DNA-bd

    Graphical View of Domain Structure for InterPro Entry O60356

    ProtoNet protein and cluster: O60356

    UniProtKB/Swiss-Prot: NUPR1_HUMAN, O60356
    Domain: Has been proposed to exhibit the features of HMG-I(Y) proteins (PubMed:11056169)
    Similarity: Belongs to the NUPR family


    Function
    for NUPR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUPR1_HUMAN, O60356
    Function: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells
    with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its
    activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription,
    leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal
    adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast
    cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation
    and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as
    doxorubicin
    Induction: Up-regulated by stress agents, such as nutrient deprivation (at protein level). Up-regulation by
    gamma-irradiation is eventually followed by down-regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
         
    NUPR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NUPR1:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nupr1):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    NUPR1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Nupr1tm1Jlio for NUPR1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NUPR1 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): NUPR1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUPR1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NUPR1:
    hsa-miR-608 hsa-miR-3176 hsa-miR-766 hsa-miR-3922-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: NUPR1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUPR1 (see all 4)
    OriGene shRNA RFP: NUPR1
    OriGene siRNA: NUPR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUPR1
    Sirion Biotech Custom design and validation of potent shRNA sequences against NUPR1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NUPR1
    Sirion Biotech Customized adenovirus for overexpression of NUPR1 
    Sirion Biotech Customized adenovirus for potent knockdown of NUPR1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUPR1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUPR1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NUPR1 (NM_012385)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUPR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUPR1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NUPR1
    Search LifeMap BioReagents cell lines for NUPR1
    Sirion Biotech Customized stable knockdown cell line services for NUPR1 
    Sirion Biotech Customized inducible knockdown cell line services for NUPR1
    Sirion Biotech Customized stable overexpressing cell line services for NUPR1
    Sirion Biotech Customized inducible overexpressing cell line services for NUPR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUPR1


    Pathways & Interactions
    for NUPR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUPR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for NUPR1 (O603563 ENSP000003790034) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151723, ENSP000002500034I2D: score=1 STRING: ENSP00000250003
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    PAXIP1Q6ZW493, ENSP000003840484I2D: score=3 STRING: ENSP00000384048
    CREBBPENSP000002623674STRING: ENSP00000262367
    ATF2ENSP000002641104STRING: ENSP00000264110
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002526acute inflammatory response IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006461protein complex assembly IEA--
    GO:0006473protein acetylation IEA--

    NUPR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NUPR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUPR1
    Search CenterWatch for drugs/clinical trials and news about NUPR1 

    Transcripts
    for NUPR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUPR1 gene (2 alternative transcripts): 
    NM_001042483.1  NM_012385.2  

    Unigene Cluster for NUPR1:

    Nuclear protein, transcriptional regulator, 1
    Hs.513463  [show with all ESTs]
    Unigene Representative Sequence: BG284742
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324873(uc002dqe.1 uc002dqd.1) ENST00000567646 ENST00000395641


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): NUPR1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUPR1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NUPR1:
    hsa-miR-608 hsa-miR-3176 hsa-miR-766 hsa-miR-3922-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: NUPR1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUPR1 (see all 4)
    OriGene shRNA RFP: NUPR1
    OriGene siRNA: NUPR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUPR1
    Sirion Biotech Custom design and validation of potent shRNA sequences against NUPR1 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUPR1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUPR1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NUPR1 (NM_012385)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUPR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUPR1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUPR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUPR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUPR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUPR1

    Additional cDNA sequence: 

    AF069073.1 AF135266.2 AK312135.1 BC002434.2 BT006896.1 CR542144.1 

    16 DOTS entries:

    DT.95306732  DT.100818558  DT.100818561  DT.447027  DT.95133556  DT.120696130  DT.120695415  DT.120695542 
    DT.120697313  DT.95133548  DT.95133555  DT.120696097  DT.95133557  DT.100818560  DT.75103574  DT.87007864 

    24/298 AceView cDNA sequences (see all 298):

    BI063754 BX476466 BG032212 CF129882 BI042849 CB110810 AI205867 AI028120 
    CF127387 BM792863 BU689191 CA427541 AW672895 AV654414 BI063225 BQ882705 
    BM818419 BE733234 CB117339 AV646071 BQ671399 BU527176 CF129289 CF130111 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NUPR1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                          -                           
    SP2:                    -     -                           
    SP3:                    -                                 


    ECgene alternative splicing isoforms for NUPR1

    Expression
    for NUPR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUPR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACACTACAC
    NUPR1 Expression
    About this image

    NUPR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerCholinergic Amacrine CellsAmacrine, Retina
    KidneyPodocyte LayerPodocytesKidney
    CartilageMeckel's CartilageCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See NUPR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUPR1

    SOURCE GeneReport for Unigene cluster: Hs.513463

    UniProtKB/Swiss-Prot: NUPR1_HUMAN, O60356
    Tissue specificity: Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal
    cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small
    intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral
    blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including NUPR1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUPR1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUPR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUPR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUPR1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUPR1

    Orthologs
    for NUPR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for NUPR1 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nupr11 , 5 nuclear protein 15
    nuclear protein transcription regulator 11    		 79.65(n)1
    75.32(a)1    		   7 (69.21 cM)5
    563121  NM_019738.11  NP_062712.11 
     1266232495 


    ENSEMBL Gene Tree for NUPR1 (if available)
    TreeFam Gene Tree for NUPR1 (if available) 

    Paralogs
    for NUPR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NUPR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/79 NCBI SNPs in NUPR1 are shown (see all 79)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1841765231,2
    		--28548230(+) CACCCA/GCCTCG 2 -- int10--------
    rs1893998911,2
    		--28548350(+) TTCCCA/GTCTAT 2 -- int10--------
    rs1482898541,2
    		--28548396(+) AGGGCA/CGTGTT 2 -- int10--------
    rs1809536511,2
    		--28548407(+) TCATGA/GGCAGT 2 -- int10--------
    rs1415807791,2
    		--28548523(+) ACAGCA/GTAGAC 2 -- int10--------
    rs1504703161,2
    		--28548610(+) CTCATA/GAATGT 2 -- int10--------
    rs1134291281,2
    		C--28548771(+) GGGATA/CTTCCT 2 -- ut310--------
    rs1398544081,2
    		--28548866(+) AGACT-/CAGTCAG 2 -- ut310--------
    rs1116080541,2
    		C--28548943(+) CCTCCA/C/GCAGTC 4 -- ut311CSA 1
    rs1902709961,2
    		--28548944(+) CTCCGC/TAGTCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NUPR1 (28548606 - 28550495 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NUPR1
         3 CNVs: 4937 4938 3999

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUPR1
    DNA2.0 Custom Variant and Variant Library Synthesis for NUPR1

    Disorders / Diseases
    for NUPR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUPR1 for disorders           About GeneDecksing

    OMIM gene information: 614812    OMIM disorders: --

    16 diseases for NUPR1:    About MalaCards
    sertoli cell-only syndrome    cavernous malformation    cerebral cavernous malformations    q fever
    inflammatory bowel disease    synovial sarcoma    sarcoma    thyroid carcinoma
    cerebritis    pancreatic cancer    thyroiditis    prostate cancer
    breast cancer    pancreatitis    prostatitis    carcinoma

    1 Novoseek disease relationship for NUPR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 23.7 3 14607339 (1), 15957166 (1), 16101158 (1)


    Export disorders for NUPR1 gene to outside databases

    Publications
    for NUPR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUPR1 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with NUPR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. (PubMed id 10092851)1, 2, 3 Vasseur S....Iovanna J.L. (1999)
    2. Expression of a novel factor in human breast cancer cells with metastatic potential. (PubMed id 10493524)1, 2, 3 Ree A.H.... Fodstad O. (1999)
    3. Nuclear protein 1 promotes pancreatic cancer developme nt and protects cells from stress by inhibiting apoptosis. (PubMed id 22565310)1, 2 Hamidi T....Iovanna J.L. (2012)
    4. Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance. (PubMed id 22858377)1, 2 Vincent A.J.... Shevde L.A. (2012)
    5. p8/nupr1 regulates DNA-repair activity after double-s trand gamma irradiation-induced DNA damage. (PubMed id 19650074)1, 2 Gironella M....Iovanna J.L. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    8. Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. (PubMed id 9405444)1, 3 Mallo G.V....Iovanna J.L. (1997)
    9. Expression of p8 protein in medullary thyroid carcinoma. (PubMed id 16101158)1, 9 Ito Y....Miyauchi A. (2005)
    10. Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation. (PubMed id 16300740)1, 9 Malicet C....Iovanna J.L. (2006)

    External Searches for NUPR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NUPR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26471 HGNC: 29990 AceView: P8 Ensembl:ENSG00000176046 euGenes: HUgn26471
    ECgene: NUPR1 H-InvDB: NUPR1

    Other Databases showing NUPR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NUPR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUPR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUPR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUPR1 gene:
    Search GeneIP for patents involving NUPR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NUPR1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for NUPR1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUPR1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUPR1  
     OriGene Protein Over-expression Lysate for NUPR1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NUPR1   OriGene 3'-UTR Clone for NUPR1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUPR1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUPR1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NUPR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUPR1   OriGene Custom Protein Services for NUPR1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUPR1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUPR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUPR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUPR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUPR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUPR1
     GenScript Custom Purified and Recombinant Proteins Services for NUPR1 GenScript cDNA clones with any tag delivered in your preferred vector for NUPR1
     GenScript Custom Assay Services for NUPR1 GenScript Custom Superior Antibodies Services for NUPR1
     GenScript Custom overexpressing Cell Line Services for NUPR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NUPR1 promoter
     Search Chromatin IP Primers for NUPR1
     RT2 qPCR Primer Assay in human, mouse, rat NUPR1
     Search GNC Networks for NUPR1
     SABiosciences PCR Arrays including human, mouse, rat NUPR1
     Search Tocris compounds for NUPR1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NUPR1 antibodies
     NUPR1 proteins
     NUPR1 lysates
     Antibodies for NUPR1
     See all of Abcam's Antibodies, Kits and Proteins for NUPR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NUPR1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NUPR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUPR1
     SwitchGear 3'UTR luciferase reporter plasmids for NUPR1
     SwitchGear Promoter luciferase reporter plasmids for NUPR1
     Search ThermoFisher Antibodies for NUPR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUPR1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NUPR1
    Sirion Biotech Customized:
     stable knockdown cell line services for NUPR1
     inducible knockdown cell line services for NUPR1
     design and validation of potent shRNA sequences against NUPR1
     adenovirus for potent knockdown of NUPR1
     adenovirus for overexpression of NUPR1
     stable overexpressing cell line services for NUPR1
     inducible overexpressing cell line services for NUPR1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NUPR1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4