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Aliases for NUPR1 Gene

Aliases for NUPR1 Gene

  • Nuclear Protein 1, Transcriptional Regulator 2 3 5
  • Candidate Of Metastasis 1 2 3 4
  • Nuclear Transcriptional Regulator Protein 1 3 4
  • Protein P8 3 4
  • COM1 3 4
  • Nuclear Protein, Transcriptional Regulator, 1 3
  • Nuclear Protein 1 3
  • P8 3

External Ids for NUPR1 Gene

Previous GeneCards Identifiers for NUPR1 Gene

  • GC16M028457
  • GC16M026574

Summaries for NUPR1 Gene

GeneCards Summary for NUPR1 Gene

NUPR1 (Nuclear Protein 1, Transcriptional Regulator) is a Protein Coding gene. Diseases associated with NUPR1 include Pancreatic Ductal Adenocarcinoma and Pancreas Adenocarcinoma. Among its related pathways are Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for NUPR1 Gene

  • Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 Lys-16 acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

Gene Wiki entry for NUPR1 Gene

Additional gene information for NUPR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUPR1 Gene

Genomics for NUPR1 Gene

GeneHancer (GH) Regulatory Elements for NUPR1 Gene

Promoters and enhancers for NUPR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I028537 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 610 3 FOXA2 ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF766 ATF7 SP3 RXRA NUPR1 SULT1A2 TUFM ENSG00000271623 PIR42560
GH16I028542 Enhancer 1 FANTOM5 Ensembl ENCODE 0.8 -4.4 -4389 1.9 ELF3 SAP130 MLX EBF1 ZNF48 POLR2A CEBPA IKZF1 CREB1 SULT1A2 TUFM NPIPB7 CLN3 APOBR CD19 RABEP2 IL27 ENSG00000251417 SULT1A1
GH16I028531 Enhancer 1.3 FANTOM5 Ensembl ENCODE 0.4 +5.5 5518 3.7 ARID4B RAD21 RARA YY1 ZNF366 MIXL1 SMARCA5 RXRA SP5 USF2 PIR42560 SULT1A2 TUFM APOBR SGF29 NPIPB7 CLN3 IL27 ENSG00000251417 SULT1A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NUPR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NUPR1 gene promoter:

Genomic Locations for NUPR1 Gene

Genomic Locations for NUPR1 Gene
chr16:28,532,708-28,539,174
(GRCh38/hg38)
Size:
6,467 bases
Orientation:
Minus strand
chr16:28,548,606-28,550,495
(GRCh37/hg19)

Genomic View for NUPR1 Gene

Genes around NUPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUPR1 Gene

Proteins for NUPR1 Gene

  • Protein details for NUPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60356-NUPR1_HUMAN
    Recommended name:
    Nuclear protein 1
    Protein Accession:
    O60356
    Secondary Accessions:
    • B2R5C4
    • O60357
    • Q6FGG3

    Protein attributes for NUPR1 Gene

    Size:
    82 amino acids
    Molecular mass:
    8873 Da
    Quaternary structure:
    • Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex; the interaction with MORF4L1 may be mediated by MSL1.
    SequenceCaution:
    • Sequence=AAC05335.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUPR1 Gene

Post-translational modifications for NUPR1 Gene

  • Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity.

Other Protein References for NUPR1 Gene

No data available for DME Specific Peptides for NUPR1 Gene

Domains & Families for NUPR1 Gene

Gene Families for NUPR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NUPR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60356

UniProtKB/Swiss-Prot:

NUPR1_HUMAN :
  • Has been proposed to exhibit the features of HMG-I(Y) proteins.
  • Belongs to the NUPR family.
Domain:
  • Has been proposed to exhibit the features of HMG-I(Y) proteins.
Family:
  • Belongs to the NUPR family.
genes like me logo Genes that share domains with NUPR1: view

Function for NUPR1 Gene

Molecular function for NUPR1 Gene

UniProtKB/Swiss-Prot Function:
Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 Lys-16 acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.
UniProtKB/Swiss-Prot Induction:
Up-regulated by stress agents, such as nutrient deprivation (at protein level). Up-regulation by gamma-irradiation is eventually followed by down-regulation.

Phenotypes From GWAS Catalog for NUPR1 Gene

Gene Ontology (GO) - Molecular Function for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 11056169
GO:0003682 chromatin binding IEA,IBA --
GO:0005515 protein binding IPI 16478804
genes like me logo Genes that share ontologies with NUPR1: view
genes like me logo Genes that share phenotypes with NUPR1: view

Animal Models for NUPR1 Gene

MGI Knock Outs for NUPR1:

Animal Model Products

CRISPR Products

miRNA for NUPR1 Gene

miRTarBase miRNAs that target NUPR1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUPR1 Gene

Localization for NUPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUPR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUPR1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10092851
GO:0005829 cytosol IDA --
GO:0032993 protein-DNA complex IDA 11056169
genes like me logo Genes that share ontologies with NUPR1: view

Pathways & Interactions for NUPR1 Gene

genes like me logo Genes that share pathways with NUPR1: view

Pathways by source for NUPR1 Gene

1 KEGG pathway for NUPR1 Gene

Gene Ontology (GO) - Biological Process for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006461 protein complex assembly IEA --
genes like me logo Genes that share ontologies with NUPR1: view

No data available for SIGNOR curated interactions for NUPR1 Gene

Drugs & Compounds for NUPR1 Gene

No Compound Related Data Available

Transcripts for NUPR1 Gene

Unigene Clusters for NUPR1 Gene

Nuclear protein, transcriptional regulator, 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -

Relevant External Links for NUPR1 Gene

GeneLoc Exon Structure for
NUPR1
ECgene alternative splicing isoforms for
NUPR1

Expression for NUPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUPR1 Gene

This gene is overexpressed in Pancreas (54.7) and Milk (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUPR1 Gene



Protein tissue co-expression partners for NUPR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUPR1 Gene:

NUPR1

SOURCE GeneReport for Unigene cluster for NUPR1 Gene:

Hs.513463

mRNA Expression by UniProt/SwissProt for NUPR1 Gene:

O60356-NUPR1_HUMAN
Tissue specificity: Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for NUPR1 Gene

  • Pancreas(4.7)
  • Kidney(4.3)
  • Nervous system(4.2)
  • Lung(3.4)
  • Thyroid gland(2.7)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with NUPR1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUPR1 Gene

Orthologs for NUPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUPR1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUPR1 33 34
  • 86.83 (n)
cow
(Bos Taurus)
Mammalia NUPR1 33 34
  • 82.72 (n)
mouse
(Mus musculus)
Mammalia Nupr1 33 16 34
  • 79.65 (n)
rat
(Rattus norvegicus)
Mammalia P8 33
  • 79.22 (n)
oppossum
(Monodelphis domestica)
Mammalia NUPR1 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUPR1 34
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nupr1 34
  • 43 (a)
OneToOne
Species where no ortholog for NUPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUPR1 Gene

ENSEMBL:
Gene Tree for NUPR1 (if available)
TreeFam:
Gene Tree for NUPR1 (if available)

Paralogs for NUPR1 Gene

(1) SIMAP similar genes for NUPR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NUPR1: view

No data available for Paralogs for NUPR1 Gene

Variants for NUPR1 Gene

Sequence variations from dbSNP and Humsavar for NUPR1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000585154 -- 28,541,077(-) TTTTTT/TT upstream_transcript_variant
rs1002003813 -- 28,540,933(-) G/A upstream_transcript_variant
rs1002069950 -- 28,537,027(-) C/A downstream_transcript_variant
rs1003340043 -- 28,538,544(-) C/T intron_variant
rs1003881896 -- 28,538,279(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NUPR1 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
nsv1059555 CNV gain 25217958
nsv509608 CNV insertion 20534489
nsv833180 CNV loss 17160897
nsv833182 CNV gain 17160897

Variation tolerance for NUPR1 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NUPR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUPR1 Gene

Disorders for NUPR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUPR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
pancreas adenocarcinoma
  • pancreatic adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search NUPR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NUPR1

genes like me logo Genes that share disorders with NUPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUPR1 Gene

Publications for NUPR1 Gene

  1. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. (PMID: 10092851) Vasseur S … Iovanna JL (European journal of biochemistry 1999) 2 3 4 58
  2. Expression of a novel factor in human breast cancer cells with metastatic potential. (PMID: 10493524) Ree AH … Fodstad O (Cancer research 1999) 2 3 4 58
  3. Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance. (PMID: 22858377) Vincent AJ … Shevde LA (FEBS letters 2012) 3 4 58
  4. Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. (PMID: 22565310) Hamidi T … Iovanna JL (The Journal of clinical investigation 2012) 3 4 58
  5. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. (PMID: 19650074) Gironella M … Iovanna JL (Journal of cellular physiology 2009) 3 4 58

Products for NUPR1 Gene

Sources for NUPR1 Gene

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