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Aliases for NUPR1 Gene

Aliases for NUPR1 Gene

  • Nuclear Protein, Transcriptional Regulator, 1 2 3
  • Candidate Of Metastasis 1 2 3 4
  • COM1 3 4 6
  • Protein P8 3 4
  • P8 3 6
  • Nuclear Protein 1 3

External Ids for NUPR1 Gene

Summaries for NUPR1 Gene

GeneCards Summary for NUPR1 Gene

NUPR1 (Nuclear Protein, Transcriptional Regulator, 1) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for NUPR1 Gene

  • Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 Lys-16 acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

Gene Wiki entry for NUPR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUPR1 Gene

Genomics for NUPR1 Gene

Genomic Location for NUPR1 Gene

Start:
28,532,708 bp from pter
End:
28,539,174 bp from pter
Size:
6,467 bases
Orientation:
Minus strand

Genomic View for NUPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUPR1 Gene

Regulatory Elements for NUPR1 Gene

Proteins for NUPR1 Gene

  • Protein details for NUPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60356-NUPR1_HUMAN
    Recommended name:
    Nuclear protein 1
    Protein Accession:
    O60356
    Secondary Accessions:
    • B2R5C4
    • O60357
    • Q6FGG3

    Protein attributes for NUPR1 Gene

    Size:
    82 amino acids
    Molecular mass:
    8873 Da
    Quaternary structure:
    • Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex; the interaction with MORF4L1 may be mediated by MSL1.
    SequenceCaution:
    • Sequence=AAC05335.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUPR1 Gene

Proteomics data for NUPR1 Gene at MOPED

Post-translational modifications for NUPR1 Gene

  • Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUPR1 Gene

No data available for DME Specific Peptides for NUPR1 Gene

Domains for NUPR1 Gene

Protein Domains for NUPR1 Gene

UniProtKB/Swiss-Prot:

NUPR1_HUMAN
Domain:
  • Has been proposed to exhibit the features of HMG-I(Y) proteins.:
    • O60356
Family:
  • Belongs to the NUPR family.:
    • O60356
genes like me logo Genes that share domains with NUPR1: view

No data available for Gene Families for NUPR1 Gene

Function for NUPR1 Gene

Molecular function for NUPR1 Gene

UniProtKB/Swiss-Prot Function: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 Lys-16 acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.
UniProtKB/Swiss-Prot Induction: Up-regulated by stress agents, such as nutrient deprivation (at protein level). Up-regulation by gamma-irradiation is eventually followed by down-regulation.

Gene Ontology (GO) - Molecular Function for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NUPR1: view
genes like me logo Genes that share phenotypes with NUPR1: view

Animal Models for NUPR1 Gene

MGI Knock Outs for NUPR1:

miRNA for NUPR1 Gene

miRTarBase miRNAs that target NUPR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NUPR1 Gene

Localization for NUPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUPR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUPR1 Gene COMPARTMENTS Subcellular localization image for NUPR1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NUPR1: view

Pathways for NUPR1 Gene

genes like me logo Genes that share pathways with NUPR1: view

Pathways by source for NUPR1 Gene

1 KEGG pathway for NUPR1 Gene

Gene Ontology (GO) - Biological Process for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006461 protein complex assembly IEA --
GO:0006473 protein acetylation IEA --
genes like me logo Genes that share ontologies with NUPR1: view

Transcripts for NUPR1 Gene

Unigene Clusters for NUPR1 Gene

Nuclear protein, transcriptional regulator, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -

Relevant External Links for NUPR1 Gene

GeneLoc Exon Structure for
NUPR1
ECgene alternative splicing isoforms for
NUPR1

Expression for NUPR1 Gene

mRNA expression in normal human tissues for NUPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NUPR1 Gene

SOURCE GeneReport for Unigene cluster for NUPR1 Gene Hs.513463

mRNA Expression by UniProt/SwissProt for NUPR1 Gene

O60356-NUPR1_HUMAN
Tissue specificity: Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes.
genes like me logo Genes that share expressions with NUPR1: view

Orthologs for NUPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUPR1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUPR1 36
  • 82.72 (n)
  • 82.72 (a)
NUPR1 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUPR1 36
  • 86.83 (n)
  • 87.65 (a)
NUPR1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nupr1 36
  • 79.65 (n)
  • 75.32 (a)
Nupr1 16
Nupr1 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUPR1 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUPR1 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nupr1 36
  • 79.22 (n)
  • 76.62 (a)
zebrafish
(Danio rerio)
Actinopterygii nupr1 37
  • 43 (a)
OneToOne
Species with no ortholog for NUPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUPR1 Gene

ENSEMBL:
Gene Tree for NUPR1 (if available)
TreeFam:
Gene Tree for NUPR1 (if available)

Paralogs for NUPR1 Gene

Selected SIMAP similar genes for NUPR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NUPR1: view

No data available for Paralogs for NUPR1 Gene

Variants for NUPR1 Gene

Sequence variations from dbSNP and Humsavar for NUPR1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs151226 -- 28,538,502(-) ATGTT(G/T)CCCAG intron-variant
rs151227 -- 28,538,187(-) ATGCC(C/T)ACTTC reference, synonymous-codon, intron-variant
rs180853 -- 28,540,995(+) ggtct(A/C)gaact upstream-variant-2KB
rs3785354 -- 28,539,346(+) CAGGA(C/T)GTGAG upstream-variant-2KB
rs4788082 -- 28,540,571(-) TTTCA(C/T)TCAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NUPR1 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
dgv843e1 CNV Complex 17122850
nsv833180 CNV Loss 17160897
nsv509608 CNV Insertion 20534489
nsv905689 CNV Loss 21882294
nsv833182 CNV Gain 17160897

Relevant External Links for NUPR1 Gene

HapMap Linkage Disequilibrium report
NUPR1

Disorders for NUPR1 Gene

(1) Novoseek inferred disease relationships for NUPR1 Gene

Disease -log(P) Hits PubMed IDs
metastasis 23.7 3

Relevant External Links for NUPR1

Genetic Association Database (GAD)
NUPR1
genes like me logo Genes that share disorders with NUPR1: view

No data available for UniProtKB/Swiss-Prot for NUPR1 Gene

Publications for NUPR1 Gene

  1. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. (PMID: 10092851) Vasseur S. … Iovanna J.L. (Eur. J. Biochem. 1999) 2 3 4
  2. Expression of a novel factor in human breast cancer cells with metastatic potential. (PMID: 10493524) Ree A.H. … Fodstad O. (Cancer Res. 1999) 2 3 4
  3. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4
  4. Expression of p8 protein in medullary thyroid carcinoma. (PMID: 16101158) Ito Y. … Miyauchi A. (Anticancer Res. 2005) 3 23
  5. Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation. (PMID: 16300740) Malicet C. … Iovanna J.L. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for NUPR1 Gene

Sources for NUPR1 Gene

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