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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUPR1 Gene

protein-coding   GIFtS: 53
GCID: GC16M028548

Nuclear Protein, Transcriptional Regulator, 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Protein, Transcriptional Regulator, 11 2
Candidate Of Metastasis 11 2 3
Protein P82 3
COM12 3
P82
Nuclear Protein 12

External Ids:    HGNC: 299901   Entrez Gene: 264712   Ensembl: ENSG000001760467   OMIM: 6148125   UniProtKB: O603563   

Export aliases for NUPR1 gene to outside databases

Previous GC identifers: GC16M028457 GC16M026574


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NUPR1 Gene: 
NUPR1 (nuclear protein, transcriptional regulator, 1) is a protein-coding gene. Diseases associated with NUPR1 include sertoli cell-only syndrome, and q fever. GO annotations related to this gene include chromatin binding and molecular_function.

UniProtKB/Swiss-Prot: NUPR1_HUMAN, O60356
Function: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers
cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and
inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its
transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide
pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine
treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway,
CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to
chemotherapeutic agents, such as doxorubicin

Gene Wiki entry for NUPR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUPR1 gene promoter:
         Sox5   AP-1   NCX/Ncx   NRSF form 1   Brachyury   HSF1 (long)   NRSF form 2   HEN1   HSF1short   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUPR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUPR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUPR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

NUPR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUPR1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028548:  view genomic region     (about GC identifiers)

Start:
28,548,606 bp from pter      End:
28,550,495 bp from pter
Size:
1,890 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUPR1_HUMAN, O60356 (See protein sequence)
Recommended Name: Nuclear protein 1  
Size: 82 amino acids; 8873 Da
Subunit: Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase
complex; the interaction with MORF4L1 may be mediated by MSL1
Subcellular location: Nucleus
Sequence caution: Sequence=AAC05335.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R5C4 O60357 Q6FGG3

Explore the universe of human proteins at neXtProt for NUPR1: NX_O60356

Explore proteomics data for NUPR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60356

  • NUPR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUPR1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001035948.1  NP_036517.1  

    ENSEMBL proteins: 
     ENSP00000315559   ENSP00000456597   ENSP00000379003  

    Human Recombinant Protein Products for NUPR1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUPR1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10092851

    NUPR1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018792 Nuclear_phosphoprot_p8_DNA-bd

    Graphical View of Domain Structure for InterPro Entry O60356

    ProtoNet protein and cluster: O60356

    UniProtKB/Swiss-Prot: NUPR1_HUMAN, O60356
    Domain: Has been proposed to exhibit the features of HMG-I(Y) proteins (PubMed:11056169)
    Similarity: Belongs to the NUPR family


    NUPR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUPR1_HUMAN, O60356
    Function: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers
    cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and
    inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its
    transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide
    pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine
    treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway,
    CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to
    chemotherapeutic agents, such as doxorubicin
    Induction: Up-regulated by stress agents, such as nutrient deprivation (at protein level). Up-regulation by
    gamma-irradiation is eventually followed by down-regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
         
    NUPR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NUPR1:
     Decreased viability of wild-ty  Increased HPV18 LCR reporter a 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nupr1):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    NUPR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nupr1tm1Jlio for NUPR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUPR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUPR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUPR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUPR1 

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NUPR1:
    hsa-miR-608 hsa-miR-3176 hsa-miR-766 hsa-miR-3922-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidNUPR1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUPR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUPR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for NUPR1):
        Transcriptional misregulation in cancer


    NUPR1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUPR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for NUPR1 (O603563 ENSP000003790034) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOD1P151723, ENSP000002500034I2D: score=1 STRING: ENSP00000250003
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    PAXIP1Q6ZW493, ENSP000003840484I2D: score=3 STRING: ENSP00000384048
    CREBBPENSP000002623674STRING: ENSP00000262367
    ATF2ENSP000002641104STRING: ENSP00000264110
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002526acute inflammatory response IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006461protein complex assembly IEA--
    GO:0006473protein acetylation IEA--

    NUPR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUPR1

    Search CenterWatch for drugs/clinical trials and news about NUPR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUPR1 gene (2 alternative transcripts): 
    NM_001042483.1  NM_012385.2  

    Unigene Cluster for NUPR1:

    Nuclear protein, transcriptional regulator, 1
    Hs.513463  [show with all ESTs]
    Unigene Representative Sequence: BG284742
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324873(uc002dqe.1 uc002dqd.1) ENST00000567646 ENST00000395641

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NUPR1:
    hsa-miR-608 hsa-miR-3176 hsa-miR-766 hsa-miR-3922-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidNUPR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUPR1
    Clone
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    OriGene clones in human, mouse for NUPR1 (see all 11)
    OriGene ORF clones in mouse, rat for NUPR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NUPR1 (NM_012385)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUPR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUPR1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUPR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUPR1

    Additional mRNA sequence: 

    AF069073.1 AF135266.2 AK312135.1 BC002434.2 BT006896.1 CR542144.1 

    16 DOTS entries:

    DT.95306732  DT.100818558  DT.100818561  DT.447027  DT.95133556  DT.120696130  DT.120695415  DT.120695542 
    DT.120697313  DT.95133548  DT.95133555  DT.120696097  DT.95133557  DT.100818560  DT.75103574  DT.87007864 

    24/298 AceView cDNA sequences (see all 298):

    BQ882705 CR542144 BQ447894 CF129563 CF129289 D31473 AV646071 AV697872 
    CF129882 AV646090 BU625445 BI063225 CB117339 BM792863 CA425212 CF129067 
    CA427541 BU688073 BU527176 BE733234 BI063754 BU689191 BF983321 AV654414 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NUPR1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                          -                           
    SP2:                    -     -                           
    SP3:                    -                                 


    ECgene alternative splicing isoforms for NUPR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUPR1 expression in normal human tissues (normalized intensities)      NUPR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACTACAC
    NUPR1 Expression
    About this image


    NUPR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Meckel's Cartilage
             skeleton/cranium/viscerocranium   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Chondrocytes Zeugopod Epiphyseal End
             Human Calvarial Osteoblasts (HCO)   
             skeleton/cranium/viscerocranium   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem 4D20.8, NCr-fac Progenitor
             skeleton/cranium/viscerocranium   
     
     Fibroblast
             Detroit 551
             Human Prostate Fibroblasts (HPrF)   

    See NUPR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUPR1

    SOURCE GeneReport for Unigene cluster: Hs.513463

    UniProtKB/Swiss-Prot: NUPR1_HUMAN, O60356
    Tissue specificity: Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal
    cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small
    intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in
    peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including NUPR1: 
              Apoptosis 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUPR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUPR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NUPR1 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nupr11 , 5 nuclear protein 15
    nuclear protein transcription regulator 11
    79.65(n)1
    75.32(a)1
      7 (69.21 cM)5
    563121  NM_019738.11  NP_062712.11 
     1266232495 
    zebrafish
    (Danio rerio)
    Actinopterygii nupr16
    nuclear protein 1
    43(a)
    1 ↔ 1
    3(15109869-15110752)


    ENSEMBL Gene Tree for NUPR1 (if available)
    TreeFam Gene Tree for NUPR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUPR1 gene
    1 SIMAP similar gene for NUPR1 using alignment to 2 protein entries:     NUPR1_HUMAN (see all proteins):
    NUPR1L

    NUPR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 SNPs in NUPR1 are shown (see all 99)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841765231,2
    C--28548230(+) CACCCA/GCCTCG 2 -- int10--------
    rs1893998911,2
    --28548350(+) TTCCCA/GTCTAT 2 -- int10--------
    rs1482898541,2
    --28548396(+) AGGGCA/CGTGTT 2 -- int10--------
    rs1809536511,2
    C--28548407(+) TCATGA/GGCAGT 2 -- int10--------
    rs1415807791,2
    --28548523(+) ACAGCA/GTAGAC 2 -- int10--------
    rs1504703161,2
    --28548610(+) CTCATA/GAATGT 2 -- int10--------
    rs1134291281,2
    C--28548771(+) GGGATA/CTTCCT 2 -- ut310--------
    rs1398544081,2
    C--28548866(+) AGACT-/CAGTCAG 2 -- ut310--------
    rs1116080541,2
    C,F--28548943(+) CCTCCA/C/GCAGTC 4 -- ut311CSA 1
    rs1902709961,2
    --28548944(+) CTCCGC/TAGTCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NUPR1 (28548606 - 28550495 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NUPR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509608CNV Insertion20534489
    nsv905689CNV Loss21882294
    nsv833180CNV Loss17160897
    nsv833182CNV Gain17160897
    dgv843e1CNV Complex17122850
    dgv842e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614812    OMIM disorders: --

    16 diseases for NUPR1:    About MalaCards
    sertoli cell-only syndrome    q fever    synovial sarcoma    cavernous malformation
    cerebral cavernous malformation    pancreatic ductal adenocarcinoma    inflammatory bowel disease    cerebritis
    pancreatic cancer    sarcoma    thyroiditis    pancreatitis
    prostate cancer    prostatitis    breast cancer    adenocarcinoma


    NUPR1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for NUPR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 23.7 3 14607339 (1), 15957166 (1), 16101158 (1)

    Genetic Association Database (GAD): NUPR1

    Export disorders for NUPR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUPR1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with NUPR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. (PubMed id 10092851)1, 2, 3 Vasseur S....Iovanna J.L. (1999)
    2. Expression of a novel factor in human breast cancer cells with metastatic potential. (PubMed id 10493524)1, 2, 3 Ree A.H.... Fodstad O. (1999)
    3. Nuclear protein 1 promotes pancreatic cancer developme nt and protects cells from stress by inhibiting apoptosis. (PubMed id 22565310)1, 2 Hamidi T....Iovanna J.L. (2012)
    4. Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance. (PubMed id 22858377)1, 2 Vincent A.J.... Shevde L.A. (2012)
    5. Common variants at five new loci associated with earl y-onset inflammatory bowel disease. (PubMed id 19915574)1, 4 Imielinski M....McGovern D. (2009)
    6. p8/nupr1 regulates DNA-repair activity after double-s trand gamma irradiation-induced DNA damage. (PubMed id 19650074)1, 2 Gironella M....Iovanna J.L. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    9. Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. (PubMed id 9405444)1, 3 Mallo G.V....Iovanna J.L. (1997)
    10. Expression of p8 protein in medullary thyroid carcinoma. (PubMed id 16101158)1, 9 Ito Y....Miyauchi A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26471 HGNC: 29990 AceView: P8 Ensembl:ENSG00000176046 euGenes: HUgn26471
    ECgene: NUPR1 Kegg: 26471 H-InvDB: NUPR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUPR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUPR1 gene:
    Search GeneIP for patents involving NUPR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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