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Aliases for NUPR1 Gene

Aliases for NUPR1 Gene

  • Nuclear Protein 1, Transcriptional Regulator 2 3 5
  • Candidate Of Metastasis 1 2 3 4
  • Nuclear Transcriptional Regulator Protein 1 3 4
  • Protein P8 3 4
  • COM1 3 4
  • Nuclear Protein, Transcriptional Regulator, 1 3
  • Nuclear Protein 1 3
  • P8 3

External Ids for NUPR1 Gene

Previous GeneCards Identifiers for NUPR1 Gene

  • GC16M028457
  • GC16M026574

Summaries for NUPR1 Gene

GeneCards Summary for NUPR1 Gene

NUPR1 (Nuclear Protein 1, Transcriptional Regulator) is a Protein Coding gene. Diseases associated with NUPR1 include Sertoli Cell-Only Syndrome and Pancreatic Ductal Adenocarcinoma. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for NUPR1 Gene

  • Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 Lys-16 acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

Gene Wiki entry for NUPR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUPR1 Gene

Genomics for NUPR1 Gene

Regulatory Elements for NUPR1 Gene

Enhancers for NUPR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G029183 1.4 Ensembl ENCODE dbSUPER 11.3 -646.1 -646099 2.9 ELF3 MLX ZFP64 ARID4B YBX1 ZNF48 RARA ZNF366 THAP11 EGR2 LOC101928215 NUPR1 ENSG00000260796 RRN3P2 ENSG00000260953 PIR39316 PIR47519
GH16G028542 1.7 FANTOM5 Ensembl ENCODE 0.7 -4.4 -4390 1.9 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SULT1A2 TUFM NFATC2IP ENSG00000260853 NPIPB7 CLN3 APOBR SGF29 EIF3CL ENSG00000260367
GH16G028537 1 ENCODE 0.7 +0.6 610 3.0 ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF766 SP3 CAVIN1 SP5 REST SULT1A2 TUFM ENSG00000271623 NUPR1 PIR42560
GH16G028531 1.5 FANTOM5 Ensembl ENCODE 0.4 +5.5 5519 3.7 ELF3 CBX3 ARID4B RAD21 RARA YY1 ZNF121 ZNF366 IKZF2 MIXL1 SULT1A2 TUFM APOBR SGF29 NPIPB7 CLN3 IL27 ENSG00000251417 SULT1A1 SPNS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUPR1 on UCSC Golden Path with GeneCards custom track

Promoters for NUPR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000280234 574 1201 ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF766 SP3 SP5 REST PPARG
ENSR00000084904 1574 401 ZMYM3

Genomic Location for NUPR1 Gene

Chromosome:
16
Start:
28,532,708 bp from pter
End:
28,539,174 bp from pter
Size:
6,467 bases
Orientation:
Minus strand

Genomic View for NUPR1 Gene

Genes around NUPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUPR1 Gene

Proteins for NUPR1 Gene

  • Protein details for NUPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60356-NUPR1_HUMAN
    Recommended name:
    Nuclear protein 1
    Protein Accession:
    O60356
    Secondary Accessions:
    • B2R5C4
    • O60357
    • Q6FGG3

    Protein attributes for NUPR1 Gene

    Size:
    82 amino acids
    Molecular mass:
    8873 Da
    Quaternary structure:
    • Monomer. Directly interacts with MSL1 and binds MORF4L1, two components of histone acetyltransferase complex; the interaction with MORF4L1 may be mediated by MSL1.
    SequenceCaution:
    • Sequence=AAC05335.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NUPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUPR1 Gene

Post-translational modifications for NUPR1 Gene

  • Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUPR1 Gene

No data available for DME Specific Peptides for NUPR1 Gene

Domains & Families for NUPR1 Gene

Protein Domains for NUPR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60356

UniProtKB/Swiss-Prot:

NUPR1_HUMAN :
  • Has been proposed to exhibit the features of HMG-I(Y) proteins.
  • Belongs to the NUPR family.
Domain:
  • Has been proposed to exhibit the features of HMG-I(Y) proteins.
Family:
  • Belongs to the NUPR family.
genes like me logo Genes that share domains with NUPR1: view

No data available for Gene Families for NUPR1 Gene

Function for NUPR1 Gene

Molecular function for NUPR1 Gene

UniProtKB/Swiss-Prot Function:
Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 Lys-16 acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.
UniProtKB/Swiss-Prot Induction:
Up-regulated by stress agents, such as nutrient deprivation (at protein level). Up-regulation by gamma-irradiation is eventually followed by down-regulation.

Gene Ontology (GO) - Molecular Function for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA,IDA 11056169
GO:0003682 chromatin binding IEA,IBA --
genes like me logo Genes that share ontologies with NUPR1: view
genes like me logo Genes that share phenotypes with NUPR1: view

Animal Models for NUPR1 Gene

MGI Knock Outs for NUPR1:

Animal Model Products

miRNA for NUPR1 Gene

miRTarBase miRNAs that target NUPR1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUPR1 Gene

Localization for NUPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUPR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUPR1 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10092851
GO:0005829 cytosol IDA --
GO:0032993 protein-DNA complex IDA 11056169
genes like me logo Genes that share ontologies with NUPR1: view

Pathways & Interactions for NUPR1 Gene

genes like me logo Genes that share pathways with NUPR1: view

Pathways by source for NUPR1 Gene

1 KEGG pathway for NUPR1 Gene

Gene Ontology (GO) - Biological Process for NUPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002526 acute inflammatory response IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006461 protein complex assembly IEA --
genes like me logo Genes that share ontologies with NUPR1: view

No data available for SIGNOR curated interactions for NUPR1 Gene

Transcripts for NUPR1 Gene

Unigene Clusters for NUPR1 Gene

Nuclear protein, transcriptional regulator, 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: -

Relevant External Links for NUPR1 Gene

GeneLoc Exon Structure for
NUPR1
ECgene alternative splicing isoforms for
NUPR1

Expression for NUPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUPR1 Gene

This gene is overexpressed in Pancreas (54.7) and Milk (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUPR1 Gene



Protein tissue co-expression partners for NUPR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NUPR1 Gene:

NUPR1

SOURCE GeneReport for Unigene cluster for NUPR1 Gene:

Hs.513463

mRNA Expression by UniProt/SwissProt for NUPR1 Gene:

O60356-NUPR1_HUMAN
Tissue specificity: Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for NUPR1 Gene

  • Pancreas(4.7)
  • Kidney(4.3)
  • Nervous system(4.2)
  • Lung(3.4)
  • Thyroid gland(2.7)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with NUPR1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUPR1 Gene

Orthologs for NUPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUPR1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUPR1 34 35
  • 86.83 (n)
cow
(Bos Taurus)
Mammalia NUPR1 34 35
  • 82.72 (n)
mouse
(Mus musculus)
Mammalia Nupr1 34 16 35
  • 79.65 (n)
rat
(Rattus norvegicus)
Mammalia Nupr1 34
  • 79.22 (n)
oppossum
(Monodelphis domestica)
Mammalia NUPR1 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUPR1 35
  • 55 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nupr1 35
  • 43 (a)
OneToOne
Species where no ortholog for NUPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUPR1 Gene

ENSEMBL:
Gene Tree for NUPR1 (if available)
TreeFam:
Gene Tree for NUPR1 (if available)

Paralogs for NUPR1 Gene

(1) SIMAP similar genes for NUPR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NUPR1: view

No data available for Paralogs for NUPR1 Gene

Variants for NUPR1 Gene

Sequence variations from dbSNP and Humsavar for NUPR1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000585154 -- 28,541,077(+) GTATC(-/TTTT)TTATT upstream-variant-2KB
rs1002003813 -- 28,540,933(+) ACCAC(A/G)CCCGG upstream-variant-2KB
rs1002069950 -- 28,537,027(+) CGTTC(A/C)CGTCT downstream-variant-500B
rs1003340043 -- 28,538,544(+) GTACA(C/T)CTGAA intron-variant
rs1003881896 -- 28,538,279(+) TTCCC(C/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUPR1 Gene

Variant ID Type Subtype PubMed ID
esv2758640 CNV gain+loss 17122850
nsv1059555 CNV gain 25217958
nsv509608 CNV insertion 20534489
nsv833180 CNV loss 17160897
nsv833182 CNV gain 17160897

Variation tolerance for NUPR1 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUPR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUPR1 Gene

Disorders for NUPR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUPR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sertoli cell-only syndrome
  • del castillo syndrome
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards
Search NUPR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUPR1

Genetic Association Database (GAD)
NUPR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUPR1
genes like me logo Genes that share disorders with NUPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUPR1 Gene

Publications for NUPR1 Gene

  1. Cloning and expression of the human p8, a nuclear protein with mitogenic activity. (PMID: 10092851) Vasseur S. … Iovanna J.L. (Eur. J. Biochem. 1999) 2 3 4 64
  2. Expression of a novel factor in human breast cancer cells with metastatic potential. (PMID: 10493524) Ree A.H. … Fodstad O. (Cancer Res. 1999) 2 3 4 64
  3. Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance. (PMID: 22858377) Vincent A.J. … Shevde L.A. (FEBS Lett. 2012) 3 4 64
  4. Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. (PMID: 22565310) Hamidi T. … Iovanna J.L. (J. Clin. Invest. 2012) 3 4 64
  5. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. (PMID: 19650074) Gironella M. … Iovanna J.L. (J. Cell. Physiol. 2009) 3 4 64

Products for NUPR1 Gene

Sources for NUPR1 Gene

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