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NUPL2 Gene

protein-coding   GIFtS: 58
GCID: GC07P023222

Nucleoporin Like 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoporin Like 21 2     NUP42 Homolog2 3
Nucleoporin-Like Protein 11 2     H_RG271G13.92
Nucleoporin HCG12 3     NLP_12
CG12 3     hCG12
NLP-12 3     Nucleoporin-Like Protein 22

External Ids:    HGNC: 170101   Entrez Gene: 110972   Ensembl: ENSG000001362437   UniProtKB: O155043   

Export aliases for NUPL2 gene to outside databases

Previous GC identifers: GC07P022929 GC07P022963 GC07P022995 GC07P023188 GC07P023103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUPL2 Gene:
NUPL2 (nucleoporin like 2) is a protein-coding gene. Diseases associated with NUPL2 include sensorineural hearing loss, and hiv-1. GO annotations related to this gene include nuclear export signal receptor activity.

UniProtKB/Swiss-Prot: NUPL2_HUMAN, O15504
Function: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case
of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope

Gene Wiki entry for NUPL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUPL2 gene promoter:
         HOXA9   HOXA9B   Sox5   AP-1   AML1a   STAT5A   HNF-3beta   YY1   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NUPL2 promoter sequence
   Search Chromatin IP Primers for NUPL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15

NUPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUPL2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P023222:  view genomic region     (about GC identifiers)

Start:
23,221,446 bp from pter      End:
23,240,630 bp from pter
Size:
19,185 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 23,273,319-23,292,503     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NUPL2_HUMAN, O15504 (See protein sequence)
Recommended Name: Nucleoporin-like protein 2  
Size: 423 amino acids; 44872 Da
Subunit: Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1.
Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro. Interacts with the HIV-1 virus
proteins Rev and Vpr. The interaction with HIV-1 Rev, a protein that mediates nuclear export of unspliced viral
RNAs, suggests that its function may be bypassed by the HIV-1 virus
Secondary accessions: A4D143 B4DP42 Q49AE7 Q9BS49
Alternative splicing: 3 isoforms:  O15504-1   O15504-2   O15504-3   

Explore the universe of human proteins at neXtProt for NUPL2: NX_O15504

Explore proteomics data for NUPL2 at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NUPL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031368.1  
    ENSEMBL proteins: 
     ENSP00000258742   ENSP00000415511   ENSP00000387330   ENSP00000401475   ENSP00000406677  
    Reactome Protein details: O15504

    NUPL2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000571 Znf_CCCH

    Graphical View of Domain Structure for InterPro Entry O15504

    ProtoNet protein and cluster: O15504

    1 Blocks protein domain: IPB000571 Zn-finger

    UniProtKB/Swiss-Prot: NUPL2_HUMAN, O15504
    Domain: The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity
    gradient, guiding the transport proteins unidirectionally with their cargo through the NPC (By similarity)
    Similarity: Contains 1 C3H1-type zinc finger


    NUPL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUPL2_HUMAN, O15504
    Function: Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case
    of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005049nuclear export signal receptor activity TAS10358091
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    NUPL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUPL2:
     Increased HPV18 LCR reporter a 

    Animal Models:
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    miRTarBase miRNAs that target NUPL2:
    hsa-mir-186-5p (MIRT044962), hsa-mir-155-5p (MIRT020618), hsa-mir-101-3p (MIRT027295), hsa-mir-34a-5p (MIRT025274)

    Block miRNA regulation of human, mouse, rat NUPL2 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUPL2_HUMAN, O15504: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic
    side. Note=Excluded from the nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005643nuclear pore IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--
    GO:0031965nuclear membrane IEA--

    NUPL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUPL2 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.93
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for NUPL2 (see all 6)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear import of Rev protein
    Nuclear Pore Complex (NPC) Disassembly
    Vpr-mediated nuclear import of PICs


    1 Kegg Pathway  (Kegg details for NUPL2):
        RNA transport


    NUPL2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUPL2
    Interactions:

        Search GeneGlobe Interaction Network for NUPL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUPL2 (O155042, 3 ENSP000002587424) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAP1Q035182, 3, ENSP000003462064MINT-7033725 I2D: score=1 STRING: ENSP00000346206
    ENSG00000206297Q035182, 3MINT-7033725 I2D: score=1 
    ENSG00000224212Q035182, 3MINT-7033725 I2D: score=1 
    ENSG00000226173Q035182, 3MINT-7033725 I2D: score=1 
    ENSG00000227816Q035182, 3MINT-7033725 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006611protein export from nucleus TAS10358091
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    NUPL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUPL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUPL2 gene: 
    NM_007342.2  

    Unigene Cluster for NUPL2:

    Nucleoporin like 2
    Hs.408241  [show with all ESTs]
    Unigene Representative Sequence: BC039333
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258742(uc003svu.3 uc003svv.3 uc011jyw.2) ENST00000485250
    ENST00000438012 ENST00000497500 ENST00000410002 ENST00000487595 ENST00000413919
    ENST00000437140 ENST00000486136 ENST00000477844(uc011jyx.2) ENST00000489145

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUPL2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUPL2
      QuantiTect SYBR Green Assays in human, mouse, rat NUPL2
      QuantiFast Probe-based Assays in human, mouse, rat NUPL2

    Additional mRNA sequence: 

    AK124359.1 AK298183.1 AK300113.1 AK312991.1 BC039333.1 BC107583.1 BT007409.1 U97198.1 

    13 DOTS entries:

    DT.445483  DT.100716470  DT.91752542  DT.100783623  DT.101955172  DT.91752543  DT.100783626  DT.40128843 
    DT.121090389  DT.100764102  DT.121090361  DT.121090364  DT.91752546 

    Selected AceView cDNA sequences (see all 198):

    AL597003 BC039333 CR616085 AA778797 T35303 T24866 CR604064 BP367798 
    CR625401 CR601421 AA730242 BM544384 F01676 CR607673 CR612404 AA551658 
    CA392407 BI438953 CR623982 CA419508 Z38640 AU135417 BQ574182 BQ639164 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUPL2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
    SP1:                                -     -     -           -     -                       -                                             
    SP2:                                -     -     -           -     -                 -     -                                             
    SP3:                                                        -     -                 -     -                                             
    SP4:                                                        -     -                                                                     
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for NUPL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUPL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCATACCAAA
    NUPL2 Expression
    About this image

    NUPL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUPL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408241

    UniProtKB/Swiss-Prot: NUPL2_HUMAN, O15504
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUPL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NUPL2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nupl21 , 5 nucleoporin like 21, 5 78.49(n)1
    76.11(a)1
      5 (10.72 cM)5
    2310421  NM_153092.41  NP_694732.31 
     241649635 
    chicken
    (Gallus gallus)
    Aves LOC1008575291 nucleoporin-like protein 2-like 65.43(n)
    70.37(a)
      100857529  XM_003640689.2  XP_003640737.2 
    lizard
    (Anolis carolinensis)
    Reptilia NUPL26
    nucleoporin like 2
    44(a)
    1 ↔ 1
    6(30426922-30436378)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL853154.22   -- 73.14(n)    AL853154.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nupl21 nucleoporin like 2 49.37(n)
    44.59(a)
      406491  NM_213210.1  NP_998375.1 


    ENSEMBL Gene Tree for NUPL2 (if available)
    TreeFam Gene Tree for NUPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUPL2 (see all 497)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819021581,2
    --23219614(+) CCACAA/GAATTC 1 -- us2k10--------
    rs1513218611,2
    C--23219706(+) CATTAC/GAGGTA 1 -- us2k10--------
    rs1406289411,2
    --23219708(+) TTACAA/GGTAAC 1 -- us2k10--------
    rs1864477701,2
    C--23219722(+) ACAAAC/TTGAAA 1 -- us2k10--------
    rs1896339541,2
    --23219731(+) AATTGC/TGCACA 1 -- us2k10--------
    rs1810308611,2
    --23219755(+) AAACCG/TCAGCA 1 -- us2k10--------
    rs1504883661,2
    --23219894(+) GAAAAC/GGAAAA 1 -- us2k10--------
    rs732758251,2
    C,F--23219964(+) GAACTG/CAACCC 1 -- us2k13Minor allele frequency- C:0.06WA 122
    rs1862164421,2
    --23220174(+) TGGTTC/GAGGAA 1 -- us2k10--------
    rs102545441,2
    C,F,H--23220235(+) ATAAAT/CGAATT 1 -- us2k123Minor allele frequency- C:0.34NS EA NA WA 2488

    HapMap Linkage Disequilibrium report for NUPL2 (23221446 - 23240630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUPL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734129CNV Deletion23290073
    nsv526131CNV Loss19592680
    nsv887840CNV Loss21882294
    nsv7393OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for NUPL2:    
    About MalaCards
    sensorineural hearing loss    hiv-1    influenza    malaria
    hepatitis


    NUPL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUPL2
    Human Genome Epidemiology (HuGE) Navigator: NUPL2 (2 documents)

    Export disorders for NUPL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUPL2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with NUPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. (PubMed id 10358091)1, 2, 3 Farjot G.... Mikaelian I. (J. Biol. Chem. 1999)
    2. Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea. (PubMed id 9450185)1, 2, 3 Van Laer L.... Willems P. (Eur. J. Hum. Genet. 1997)
    3. Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA. (PubMed id 16000379)1, 2, 9 Kendirgi F.... Wente S.R. (Mol. Biol. Cell 2005)
    4. Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. (PubMed id 12228227)1, 2, 9 Le Rouzic E.... Benichou S. (J. Biol. Chem. 2002)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    8. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. (PubMed id 10228171)1, 2 Katahira J....Hurt E. (EMBO J. 1999)
    9. The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr255p. (PubMed id 10610322)1, 2 Strahm Y.... Stutz F. (EMBO J. 1999)
    10. The nucleoporin-like protein NLP1 (hCG1) promotes CRM1-dependent nuclear protein export. (PubMed id 22250199)1 Waldmann I....Kehlenbach R.H. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11097 HGNC: 17010 AceView: NUPL2 Ensembl:ENSG00000136243 euGenes: HUgn11097
    ECgene: NUPL2 Kegg: 11097 H-InvDB: NUPL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUPL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUPL2 gene:
    Search GeneIP for patents involving NUPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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