Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUPL2 Gene

Aliases for NUPL2 Gene

  • Nucleoporin Like 2 2 3 5
  • Nucleoporin-Like Protein 1 2 3
  • Nucleoporin HCG1 3 4
  • NUP42 Homolog 3 4
  • NLP-1 3 4
  • CG1 3 4
  • Nucleoporin-Like Protein 2 3
  • H_RG271G13.9 3
  • NLP_1 3
  • HCG1 3

External Ids for NUPL2 Gene

Previous GeneCards Identifiers for NUPL2 Gene

  • GC07P022929
  • GC07P022963
  • GC07P022995
  • GC07P023188
  • GC07P023103
  • GC07P023222

Summaries for NUPL2 Gene

GeneCards Summary for NUPL2 Gene

NUPL2 (Nucleoporin Like 2) is a Protein Coding gene. Diseases associated with NUPL2 include Hiv-1. Among its related pathways are HIV Life Cycle and Transport of the SLBP independent Mature mRNA. GO annotations related to this gene include poly(A) RNA binding and nuclear export signal receptor activity.

UniProtKB/Swiss-Prot for NUPL2 Gene

  • Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.

Gene Wiki entry for NUPL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUPL2 Gene

Genomics for NUPL2 Gene

Regulatory Elements for NUPL2 Gene

Enhancers for NUPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G023104 1.1 ENCODE 10.6 -75.5 -75460 2.9 MLX AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 DEK KLHL7-AS1 NUPL2 FAM126A KLHL7 AK3P3
GH07G023205 0.8 ENCODE 11.6 +24.8 24774 1.9 ELF3 SOX13 FOXA2 SAP130 SIN3A CEBPG ZNF48 CTBP1 POLR2A SCRT2 KLHL7-AS1 ENSG00000226816 GPNMB NUPL2 LOC101927890
GH07G023181 1.2 ENCODE 7.7 +0.8 823 3.3 MLX CREB3L1 FEZF1 DMAP1 YY1 SP3 NFYC TBX21 MEF2D SSRP1 KLHL7-AS1 TRA2A ENSG00000226816 SNHG26 ENSG00000226329 EEF1A1P6 NUPL2
GH07G023114 0.8 Ensembl ENCODE 10.6 -66.3 -66264 2.8 BCL11A TEAD4 REST ZNF600 FOS CHD7 EZH2 KLHL7-AS1 NUPL2 FAM126A AK3P3 KLHL7
GH07G023462 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.7 +287.5 287543 13.3 MLX CREB3L1 AGO1 FEZF1 DMAP1 ZNF263 SP3 NFYC TBX21 MEF2D EEF1A1P6 TRA2A IGF2BP3 CCDC126 KLHL7-AS1 NUPL2 MALSU1 GC07P023450
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUPL2 on UCSC Golden Path with GeneCards custom track

Promoters for NUPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209472 373 2001 MLX CREB3L1 FEZF1 DMAP1 YY1 SP3 NFYC TBX21 MEF2D SSRP1

Genomic Location for NUPL2 Gene

Chromosome:
7
Start:
23,181,827 bp from pter
End:
23,201,011 bp from pter
Size:
19,185 bases
Orientation:
Plus strand

Genomic View for NUPL2 Gene

Genes around NUPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUPL2 Gene

Proteins for NUPL2 Gene

  • Protein details for NUPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15504-NUPL2_HUMAN
    Recommended name:
    Nucleoporin-like protein 2
    Protein Accession:
    O15504
    Secondary Accessions:
    • A4D143
    • B4DP42
    • Q49AE7
    • Q9BS49

    Protein attributes for NUPL2 Gene

    Size:
    423 amino acids
    Molecular mass:
    44872 Da
    Quaternary structure:
    • Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1. Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro. Interacts with the HIV-1 virus proteins Rev and Vpr. The interaction with HIV-1 Rev, a protein that mediates nuclear export of unspliced viral RNAs, suggests that its function may be bypassed by the HIV-1 virus.

    Alternative splice isoforms for NUPL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUPL2 Gene

Post-translational modifications for NUPL2 Gene

No data available for DME Specific Peptides for NUPL2 Gene

Domains & Families for NUPL2 Gene

Protein Domains for NUPL2 Gene

Suggested Antigen Peptide Sequences for NUPL2 Gene

Graphical View of Domain Structure for InterPro Entry

O15504

UniProtKB/Swiss-Prot:

NUPL2_HUMAN :
  • The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
Domain:
  • The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.
genes like me logo Genes that share domains with NUPL2: view

No data available for Gene Families for NUPL2 Gene

Function for NUPL2 Gene

Molecular function for NUPL2 Gene

UniProtKB/Swiss-Prot Function:
Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.

Gene Ontology (GO) - Molecular Function for NUPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005049 nuclear export signal receptor activity IDA 10358091
GO:0005515 protein binding IPI 10358091
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NUPL2: view

Phenotypes for NUPL2 Gene

genes like me logo Genes that share phenotypes with NUPL2: view

Animal Model Products

CRISPR Products

miRNA for NUPL2 Gene

miRTarBase miRNAs that target NUPL2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUPL2 Gene

Localization for NUPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUPL2 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Excluded from the nucleolus. {ECO:0000269 PubMed:10358091}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUPL2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for NUPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10358091
GO:0005635 colocalizes_with nuclear envelope IDA 22250199
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with NUPL2: view

Pathways & Interactions for NUPL2 Gene

SuperPathways for NUPL2 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUPL2: view

Pathways by source for NUPL2 Gene

Gene Ontology (GO) - Biological Process for NUPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006611 protein export from nucleus IGI 22250199
GO:0006810 transport IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NUPL2: view

No data available for SIGNOR curated interactions for NUPL2 Gene

Drugs & Compounds for NUPL2 Gene

No Compound Related Data Available

Transcripts for NUPL2 Gene

Unigene Clusters for NUPL2 Gene

Nucleoporin like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUPL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5:
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: -
SP10:
SP11: -
SP12:

Relevant External Links for NUPL2 Gene

GeneLoc Exon Structure for
NUPL2
ECgene alternative splicing isoforms for
NUPL2

Expression for NUPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUPL2 Gene

Protein differential expression in normal tissues from HIPED for NUPL2 Gene

This gene is overexpressed in Lung (24.7), Placenta (10.7), and CD8 Tcells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUPL2 Gene



Protein tissue co-expression partners for NUPL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUPL2 Gene:

NUPL2

SOURCE GeneReport for Unigene cluster for NUPL2 Gene:

Hs.408241

mRNA Expression by UniProt/SwissProt for NUPL2 Gene:

O15504-NUPL2_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for NUPL2 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with NUPL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUPL2 Gene

Orthologs for NUPL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NUPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUPL2 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia NUPL2 34 35
  • 87.35 (n)
cow
(Bos Taurus)
Mammalia NUPL2 35 34
  • 85.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nupl2 34 16 35
  • 78.49 (n)
rat
(Rattus norvegicus)
Mammalia Nupl2 34
  • 77.97 (n)
oppossum
(Monodelphis domestica)
Mammalia NUPL2 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUPL2 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857529 34
  • 65.43 (n)
NUPL2 35
  • 47 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
-- 35
  • 31 (a)
OneToMany
-- 35
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia NUPL2 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nupl2 34
  • 55.18 (n)
zebrafish
(Danio rerio)
Actinopterygii nupl2 34 35
  • 49.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToOne
Species where no ortholog for NUPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUPL2 Gene

ENSEMBL:
Gene Tree for NUPL2 (if available)
TreeFam:
Gene Tree for NUPL2 (if available)

Paralogs for NUPL2 Gene

Pseudogenes.org Pseudogenes for NUPL2 Gene

genes like me logo Genes that share paralogs with NUPL2: view

No data available for Paralogs for NUPL2 Gene

Variants for NUPL2 Gene

Sequence variations from dbSNP and Humsavar for NUPL2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000017553 -- 23,189,226(+) ACTTT(A/C)AAGCA intron-variant
rs1000192394 -- 23,189,907(+) GACTC(C/T)GTCTC intron-variant
rs1000294584 -- 23,195,204(+) TTAAT(A/T)CCCTT intron-variant, upstream-variant-2KB
rs1000319317 -- 23,183,979(+) ATTAA(C/T)GGCTT intron-variant
rs1000373130 -- 23,183,507(+) TGAGC(C/G)ACCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUPL2 Gene

Variant ID Type Subtype PubMed ID
esv2734129 CNV deletion 23290073
nsv1027363 CNV gain 25217958
nsv473535 CNV novel sequence insertion 20440878
nsv526131 CNV loss 19592680
nsv7393 OTHER inversion 18451855

Variation tolerance for NUPL2 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUPL2 Gene

Disorders for NUPL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NUPL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search NUPL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUPL2

Genetic Association Database (GAD)
NUPL2
Human Genome Epidemiology (HuGE) Navigator
NUPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUPL2
genes like me logo Genes that share disorders with NUPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUPL2 Gene

Publications for NUPL2 Gene

  1. Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA. (PMID: 16000379) Kendirgi F. … Wente S.R. (Mol. Biol. Cell 2005) 3 4 22 64
  2. Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. (PMID: 12228227) Le Rouzic E. … Benichou S. (J. Biol. Chem. 2002) 3 4 22 64
  3. A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1. (PMID: 10358091) Farjot G. … Mikaelian I. (J. Biol. Chem. 1999) 2 3 4 64
  4. Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea. (PMID: 9450185) Van Laer L. … Willems P. (Eur. J. Hum. Genet. 1997) 2 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for NUPL2 Gene

Sources for NUPL2 Gene

Content
Loading form....