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Aliases for NUPL1 Gene

Aliases for NUPL1 Gene

  • Nucleoporin Like 1 2 3
  • Nucleoporin-Like Protein 1 3 4
  • KIAA0410 4 6
  • Nucleoporin P58/P45 3
  • PRO2463 3

External Ids for NUPL1 Gene

Previous GeneCards Identifiers for NUPL1 Gene

  • GC13P019855
  • GC13P024805
  • GC13P023673
  • GC13P024773
  • GC13P025875
  • GC13P006690

Summaries for NUPL1 Gene

Entrez Gene Summary for NUPL1 Gene

  • This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUPL1 Gene

NUPL1 (Nucleoporin Like 1) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUPL1 Gene

  • Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Gene Wiki entry for NUPL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUPL1 Gene

Genomics for NUPL1 Gene

Regulatory Elements for NUPL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUPL1 Gene

Start:
25,301,524 bp from pter
End:
25,349,800 bp from pter
Size:
48,277 bases
Orientation:
Plus strand

Genomic View for NUPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUPL1 Gene

Proteins for NUPL1 Gene

  • Protein details for NUPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVL2-NUPL1_HUMAN
    Recommended name:
    Nucleoporin p58/p45
    Protein Accession:
    Q9BVL2
    Secondary Accessions:
    • A6NI12
    • B4DZJ1
    • O43160
    • Q5JRG2
    • Q5JRG5

    Protein attributes for NUPL1 Gene

    Size:
    599 amino acids
    Molecular mass:
    60897 Da
    Quaternary structure:
    • Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).
    Miscellaneous:
    • In rat, the p62 complex contains two different isoforms of NUPL1. Isoform p45 has however not been isolated in human so far
    SequenceCaution:
    • Sequence=BAA23706.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUPL1 Gene

    Alternative splice isoforms for NUPL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUPL1 Gene

Proteomics data for NUPL1 Gene at MOPED

Post-translational modifications for NUPL1 Gene

Other Protein References for NUPL1 Gene

Antibody Products

No data available for DME Specific Peptides for NUPL1 Gene

Domains for NUPL1 Gene

Protein Domains for NUPL1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUPL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVL2

UniProtKB/Swiss-Prot:

NUPL1_HUMAN :
  • Q9BVL2
Domain:
  • Contains FG repeats
Family:
  • Belongs to the NUPL1 family.
genes like me logo Genes that share domains with NUPL1: view

No data available for Gene Families for NUPL1 Gene

Function for NUPL1 Gene

Molecular function for NUPL1 Gene

UniProtKB/Swiss-Prot Function:
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Gene Ontology (GO) - Molecular Function for NUPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IEA --
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with NUPL1: view
genes like me logo Genes that share phenotypes with NUPL1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUPL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUPL1 Gene

Localization for NUPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUPL1 Gene

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUPL1 Gene COMPARTMENTS Subcellular localization image for NUPL1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NUPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with NUPL1: view

Pathways for NUPL1 Gene

SuperPathways for NUPL1 Gene

genes like me logo Genes that share pathways with NUPL1: view

Pathways by source for NUPL1 Gene

42 Reactome pathways for NUPL1 Gene
1 KEGG pathway for NUPL1 Gene

Gene Ontology (GO) - Biological Process for NUPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008645 hexose transport TAS --
genes like me logo Genes that share ontologies with NUPL1: view

Transcripts for NUPL1 Gene

Unigene Clusters for NUPL1 Gene

Nucleoporin like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUPL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUPL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - - -
SP2:
SP3: - - - - - - - -
SP4:
SP5: - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - -
SP9:
SP10: - - - - - - -
SP11:
SP12: - - -
SP13:
SP14: - -

ExUns: 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20
SP1:
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for NUPL1 Gene

GeneLoc Exon Structure for
NUPL1
ECgene alternative splicing isoforms for
NUPL1

Expression for NUPL1 Gene

mRNA expression in normal human tissues for NUPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NUPL1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (16.0) and Placenta (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUPL1 Gene

SOURCE GeneReport for Unigene cluster for NUPL1 Gene Hs.507537

genes like me logo Genes that share expressions with NUPL1: view

Expression partners for NUPL1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUPL1 Gene

Orthologs for NUPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUPL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUPL1 35
  • 89.14 (n)
  • 92.32 (a)
NUPL1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUPL1 35
  • 93.75 (n)
  • 94.55 (a)
NUPL1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nupl1 35
  • 90.06 (n)
  • 91.82 (a)
Nupl1 16
Nupl1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUPL1 35
  • 99.72 (n)
  • 99.67 (a)
NUPL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nupl1 35
  • 89.91 (n)
  • 90.43 (a)
oppossum
(Monodelphis domestica)
Mammalia NUPL1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUPL1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUPL1 35
  • 83.19 (n)
  • 88.61 (a)
NUPL1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUPL1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nupl1 35
  • 71.37 (n)
  • 75.76 (a)
Str.19038 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4435 35
nupl1 35
  • 64.51 (n)
  • 68.7 (a)
nupl1 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nup58 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1035 36
  • 39 (a)
OneToOne
Species with no ortholog for NUPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUPL1 Gene

ENSEMBL:
Gene Tree for NUPL1 (if available)
TreeFam:
Gene Tree for NUPL1 (if available)

Paralogs for NUPL1 Gene

Pseudogenes.org Pseudogenes for NUPL1 Gene

genes like me logo Genes that share paralogs with NUPL1: view

No data available for Paralogs for NUPL1 Gene

Variants for NUPL1 Gene

Sequence variations from dbSNP and Humsavar for NUPL1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs12491 -- 25,341,921(+) GTGCA(C/T)GTGCC utr-variant-3-prime
rs1129861 -- 25,335,816(+) TTAGT(A/G)TGTAT intron-variant
rs1801764 -- 25,335,847(+) ATCTT(C/T)GAGAT intron-variant
rs3045205 -- 25,339,040(+) TATTA(-/CA)AAAAG intron-variant
rs3839990 -- 25,332,538(-) AATTT(-/TTTT)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUPL1 Gene

Variant ID Type Subtype PubMed ID
nsv435952 OTHER Inversion 17901297
esv2747161 CNV Deletion 23290073
nsv899943 CNV Gain 21882294
dgv1566n71 CNV Gain 21882294

Relevant External Links for NUPL1 Gene

HapMap Linkage Disequilibrium report
NUPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUPL1 Gene

Disorders for NUPL1 Gene

No disorders were found for NUPL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NUPL1 Gene

Publications for NUPL1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (PMID: 17500595) Kaltenbach L.S. … Hughes R.E. (PLoS Genet. 2007) 3
  5. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 3

Products for NUPL1 Gene

Sources for NUPL1 Gene

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