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NUPL1 Gene

protein-coding   GIFtS: 57
GCID: GC13P025875

Nucleoporin Like 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoporin Like 11 2
Nucleoporin-Like Protein 12 3
KIAA04103 5
PRO24632
Nucleoporin P58/P452

External Ids:    HGNC: 202611   Entrez Gene: 98182   Ensembl: ENSG000001394967   OMIM: 6076155   UniProtKB: Q9BVL23   

Export aliases for NUPL1 gene to outside databases

Previous GC identifers: GC13P019855 GC13P024805 GC13P023673 GC13P024773 GC13P006690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUPL1 Gene:
This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58.
The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules
entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate
transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul
2008)

GeneCards Summary for NUPL1 Gene:
NUPL1 (nucleoporin like 1) is a protein-coding gene. Diseases associated with NUPL1 include influenza, and hiv-1. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot: NUPL1_HUMAN, Q9BVL2
Function: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear
membrane (By similarity)

Gene Wiki entry for NUPL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUPL1 gene promoter:
         STAT1   Pbx1a   POU6F1 (c2)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   En-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUPL1 promoter sequence
   Search Chromatin IP Primers for NUPL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.13   Ensembl cytogenetic band:  13q12.13   HGNC cytogenetic band: 13q12.12

NUPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUPL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P025875:  view genomic region     (about GC identifiers)

Start:
25,875,662 bp from pter      End:
25,923,938 bp from pter
Size:
48,277 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NUPL1_HUMAN, Q9BVL2 (See protein sequence)
Recommended Name: Nucleoporin p58/p45  
Size: 599 amino acids; 60897 Da
Subunit: Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUPL1. Interacts with
NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha
protein alone (By similarity)
Miscellaneous: In rat, the p62 complex contains two different isoforms of NUPL1. Isoform p45 has however not been
isolated in human so far
Sequence caution: Sequence=BAA23706.2; Type=Erroneous initiation;
Secondary accessions: A6NI12 B4DZJ1 O43160 Q5JRG2 Q5JRG5
Alternative splicing: 3 isoforms:  Q9BVL2-1   Q9BVL2-2   Q9BVL2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUPL1: NX_Q9BVL2

Explore proteomics data for NUPL1 at MOPED

Post-translational modifications: 

  • O-glycosylated (By similarity)1
  • Ubiquitination2 at Lys291, Lys330, Lys422
  • Modification sites at PhosphoSitePlus

  • See NUPL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008564.1  NP_054808.1  

    ENSEMBL proteins: 
     ENSP00000371155   ENSP00000418341   ENSP00000418904   ENSP00000418244   ENSP00000418555  
     ENSP00000371137   ENSP00000371166   ENSP00000408147  
    Reactome Protein details: Q9BVL2

    NUPL1 Human Recombinant Protein Products:

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    Novus Biologicals NUPL1 Protein
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    Cloud-Clone Corp. Proteins for NUPL1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024882 Nucleoporin_p58/p45

    Graphical View of Domain Structure for InterPro Entry Q9BVL2

    ProtoNet protein and cluster: Q9BVL2

    UniProtKB/Swiss-Prot: NUPL1_HUMAN, Q9BVL2
    Domain: Contains FG repeats
    Similarity: Belongs to the NUPL1 family


    NUPL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUPL1_HUMAN, Q9BVL2
    Function: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear
    membrane (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005487nucleocytoplasmic transporter activity IEA--
    GO:0005515protein binding IPI17500595
         
    NUPL1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NUPL1:
     Decreased influenza A virus in  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects  Nucleoplasmic pre-40S maturati 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUPL1
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    miRNA
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    miRTarBase miRNAs that target NUPL1:
    hsa-let-7a-5p (MIRT052612), hsa-mir-93-5p (MIRT027963), hsa-mir-375 (MIRT019762), hsa-let-7c-5p (MIRT051820), hsa-mir-423-3p (MIRT042540), hsa-mir-181a-5p (MIRT025113), hsa-mir-193b-3p (MIRT016328), hsa-mir-373-3p (MIRT002504)

    Block miRNA regulation of human, mouse, rat NUPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUPL1 (see all 40):
    hsa-miR-3651 hsa-miR-3142 hsa-miR-124 hsa-miR-330-3p hsa-miR-506 hsa-miR-324-5p hsa-miR-187* hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidNUPL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NUPL1

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUPL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUPL1_HUMAN, Q9BVL2: Nucleus, nuclear pore complex (By similarity). Nucleus membrane; Peripheral membrane
    protein; Cytoplasmic side (By similarity). Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By
    similarity). Note=Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the
    transporter (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope TAS--
    GO:0005643nuclear pore IEA--
    GO:0031965nuclear membrane IEA--

    NUPL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUPL1 About   (see all 14)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.93
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for NUPL1 (see all 6)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear import of Rev protein
    Nuclear Pore Complex (NPC) Disassembly
    Vpr-mediated nuclear import of PICs


    1 Kegg Pathway  (Kegg details for NUPL1):
        RNA transport


    NUPL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUPL1
    Interactions:

        Search GeneGlobe Interaction Network for NUPL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUPL1 (Q9BVL22, 3 ENSP000003711554) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273612, 3, ENSP000002630254MINT-8260570 I2D: score=2 STRING: ENSP00000263025
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    NUP62P371983, ENSP000003055034I2D: score=3 STRING: ENSP00000305503
    ABI3Q9P2A43I2D: score=1 
    NUP54ENSP000002648834STRING: ENSP00000264883
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006913nucleocytoplasmic transport ----
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    NUPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUPL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUPL1 gene (3 alternative transcripts): 
    NM_001008564.1  NM_014089.3  NM_001008565.1  

    Unigene Cluster for NUPL1:

    Nucleoporin like 1
    Hs.507537  [show with all ESTs]
    Unigene Representative Sequence: NM_014089
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381736(uc001uqi.3 uc001uqj.3) ENST00000481980 ENST00000480187
    ENST00000460326 ENST00000465068 ENST00000490231 ENST00000463407(uc001uqg.1)
    ENST00000466694 ENST00000381718 ENST00000495460 ENST00000381747 ENST00000394327
    ENST00000476553 ENST00000477876
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat NUPL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUPL1 (see all 40):
    hsa-miR-3651 hsa-miR-3142 hsa-miR-124 hsa-miR-330-3p hsa-miR-506 hsa-miR-324-5p hsa-miR-187* hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidNUPL1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): NUPL1 (NM_014089)
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    OriGene qPCR primer pairs and template standards for NUPL1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUPL1
      QuantiTect SYBR Green Assays in human, mouse, rat NUPL1
      QuantiFast Probe-based Assays in human, mouse, rat NUPL1

    Additional mRNA sequence: 

    AF113020.1 AK025800.1 AK026604.1 AK123955.1 AK302946.1 AK303409.1 BC001104.2 CR749714.1 

    18 DOTS entries:

    DT.99940945  DT.445274  DT.91766461  DT.100752514  DT.211215  DT.92012394  DT.75194666  DT.424192 
    DT.75141615  DT.91766455  DT.92048228  DT.100729687  DT.120762740  DT.120762778  DT.75164528  DT.95102765 
    DT.97795218  DT.101963964 

    Selected AceView cDNA sequences (see all 284):

    W40410 BM455470 BX115537 BU428822 BX641333 AI218033 BM698449 CR618238 
    AA296216 AB007870 BG777600 BC001104 BM807117 BI060187 AI801165 CN483139 
    BQ440072 BM055147 BU675746 BM469727 AA715045 AI624438 AW163080 BU681980 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUPL1 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:                          -     -           -           -     -                                                     -                                       
    SP2:                                                                                                                                                            
    SP3:        -     -     -     -     -           -           -     -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                          -     -           -           -     -                 -                                                                           

    ExUns: 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20
    SP1:                                          
    SP2:        -                       -         
    SP3:                                          
    SP4:        -                                 
    SP5:                                          


    ECgene alternative splicing isoforms for NUPL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUPL1 expression in normal human tissues (normalized intensities)      NUPL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGTTAGG
    NUPL1 Expression
    About this image


    NUPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    NUPL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUPL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507537
        Custom PCR Arrays for NUPL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUPL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NUPL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nupl11 , 5 nucleoporin like 11, 5 90.06(n)1
    91.82(a)1
      14 (31.62 cM)5
    718441  NM_170591.11  NP_733479.11 
     602194685 
    chicken
    (Gallus gallus)
    Aves NUPL11 nucleoporin like 1 83.19(n)
    88.61(a)
      418937  NM_001030829.1  NP_001026000.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUPL16
    nucleoporin like 1
    85(a)
    1 ↔ 1
    GL343306.1(84437-120020)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041268.12   -- 76.58(n)    BC041268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.44352 Transcribed sequence with moderate similarity to protein more 75.82(n)    BM101779.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nup586
    Nucleoporin 58
    24(a)
    1 ↔ 1
    3R(15470750-15472628)


    ENSEMBL Gene Tree for NUPL1 (if available)
    TreeFam Gene Tree for NUPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUPL1 gene

    NUPL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NUPL1
    PGOHUM00000245692


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUPL1 (see all 947)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117860571,2
    C,F--25873829(+) ATGACT/CTCTAT 2 -- us2k12Minor allele frequency- C:0.05CSA WA 120
    rs118412761,2
    C,F,H--25874004(+) gtggcG/Atgcgc 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1393970691,2
    C--25874008(+) CGTGCA/GCCTGT 2 -- us2k10--------
    rs1894687821,2
    --25874187(+) ACGTTC/TCTTTT 2 -- us2k10--------
    rs1456415141,2
    --25874266(+) GTGGCC/TATAAC 2 -- us2k10--------
    rs1820654681,2
    --25874297(+) AATTCG/TGGAGG 2 -- us2k10--------
    rs42381891,2
    C,F,A--25874436(+) atgggG/Cgaccc 2 -- us2k110Minor allele frequency- C:0.16NA WA CSA 253
    rs766541541,2
    C,F--25874518(+) GGGTAG/CGGCTT 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs47708181,2
    C,H--25874529(+) taacaT/Catgga 2 -- us2k1 tfbs34Minor allele frequency- C:0.00NS EA 420
    rs1477519961,2
    --25874712(+) GGGGGC/TTGCTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NUPL1 (25875662 - 25923938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUPL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747161CNV Deletion23290073
    dgv1566n71CNV Gain21882294
    nsv899943CNV Gain21882294
    nsv435952OTHER Inversion17901297

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUPL1
    DNA2.0 Custom Variant and Variant Library Synthesis for NUPL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607615    OMIM disorders: --

    4 diseases for NUPL1:    About MalaCards
    influenza    hiv-1    malaria    hepatitis


    NUPL1 for disorders           About GeneDecksing


    Export disorders for NUPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUPL1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with NUPL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    5. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9818 HGNC: 20261 AceView: NUPL1 Ensembl:ENSG00000139496 euGenes: HUgn9818
    ECgene: NUPL1 Kegg: 9818 H-InvDB: NUPL1

    (According to HUGE)
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    HUGE: KIAA0410

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUPL1 gene:
    Search GeneIP for patents involving NUPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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