NUP98 Gene
protein-coding GIFtS: 64
GCID: GC11M003696
|
|
nucleoporin 98kDa(Previous name: nucleoporin 98kD )
| |
Aliases
for NUP98 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleoporin 98kDa1 2 | | Nup98-Nup962 | | NUP961 2 | | GLFG-Repeat Containing Nucleoporin2 | | Nucleoporin 98kD1 | | Nuclear Pore Complex Protein Nup98-Nup962 | | ADIR22 | | ADAR23 | | NUP1962 | | |
Export aliases for NUP98 gene to outside databasesPrevious GC identifers: GC11M004267 GC11M003962 GC11M003655 GC11M003660 GC11M003652 GC11M003430 |
Summaries
for NUP98 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NUP98:
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised ofapproximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through abiogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavageresults in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmicside of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins oftransport substrates. The human gene has been shown to fuse to several genes following chromosome translocations inacute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several geneslocated in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this regionhave been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma,and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants;however, not all variants have been fully described. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948Function: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The FGrepeat domains in Nup98 have a direct role in the transport
Gene Wiki entry for NUP98
|
Genomic Views
for NUP98 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUP98 gene promoter:
Nkx3-1 v2 Nkx3-1 MEF-2A Nkx3-1 v4 Tal-1 Egr-1 Nkx3-1 v3 Nkx3-1 v1 aMEF-2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUP98
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP98 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15NUP98 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M003696: view genomic region
(about GC identifiers)
Start:
|
3,692,313 bp from pter |
End:
|
3,819,022 bp from pter |
Size:
|
126,710 bases |
Orientation:
|
minus strand |
|
Proteins
for NUP98 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948 (See
protein sequence)Recommended Name: Nuclear pore complex protein Nup98-Nup96 precursor Size: 1817 amino acids; 197579 Da
Subunit: Nup98 interacts directly with Nup96. Nup98 interacts directly with NUP88 and NUP214, subunits of thecytoplasmic filaments of the nuclear pore complex (By similarity). Nup96 is part of the Nup160 subcomplex in thenuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and intethering Nup98 and Nup153 to the nucleus. Interacts with RAE1. Interacts with vesicular stomatitis virus protein M
Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.Note=Nup96 is localized to the nucleoplasmic side of the nuclear pore complex, at or near the nucleoplasmic basket
Sequence caution: Sequence=AAD22395.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknownorigin in the C-terminal part; Sequence=AAD22396.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.Sequence of unknown origin in the C-terminal part; Sequence=AAF19342.1; Type=Erroneous initiation; Note=TranslationN-terminally extended; Sequence=AAF19342.1; Type=Frameshift; Positions=1551;
4 PDB 3D structures from  and Proteopedia  for NUP98:1KO6 (3D)
2Q5X (3D)
2Q5Y (3D)
3MMY (3D)
Secondary accessions: Q8IUT2 Q8WYB0 Q96E54 Q9H3Q4 Q9NT02 Q9UF57 Q9UHX0 Q9Y6J4 Q9Y6J5Alternative splicing: 6 isoforms: P52948-1 P52948-2 P52948-3 P52948-4 P52948-5 P52948-6 Explore the universe of human proteins at neXtProt for NUP98: NX_P52948
Post-translational modifications:
Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. CleavedNup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup961
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52948
NUP98 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_005378.4 NP_057404.2 NP_624357.1 NP_624358.2
ENSEMBL proteins: ENSP00000432275 ENSP00000316032 ENSP00000347404 ENSP00000413146 ENSP00000433515 ENSP00000433226 ENSP00000380199 ENSP00000380202 ENSP00000436226 ENSP00000432142 ENSP00000380208 ENSP00000434698 ENSP00000352091 Reactome Protein details: P52948
Human Recombinant Protein Products:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
NUP98 for ontologies About GeneDecksing
NUP98 Antibody Products:
Assay Products for NUP98: |
Protein
Domains /
Families
for NUP98 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUP98 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P52948ProtoNet protein and cluster: P52948 1 Blocks protein family: IPB007230 Nucleoporin autopeptidase
UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948Domain: Contains G-L-F-G repeatsSimilarity: Belongs to the nucleoporin GLFG familySimilarity: Contains 1 peptidase S59 domain |
Function
for NUP98 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948Function: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The FGrepeat domains in Nup98 have a direct role in the transport Genatlas biochemistry entry for NUP98:nucleoporin,essential component of multiple RNA export pathway,unlikely involved in the nuclear import of protein,fusedwith HOX9D in acute myeloid leukemia with translocation t(7;11) (p15;p15),and with DDX10 in de novo or therapy relatedmyeloid malignancies with HOXD13 in translocation t(2;11) (q35;p15) with inv11(p15-q22) and with PMX1 in translocationt(1;11) (q23;p15),with RAP1GDS1 in t(4;11)(q21;p15) in T cell acute lymphocitic leukemia,fused with TOP1 int(11;20)(p15;q11) in therapy related myelodysplastic syndrome
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP98 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP98 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): NUP98 (NM_139132) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUP98 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP98 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP98 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
NUP98 for ontologies About GeneDecksing
10 GenomeRNAi human phenotypes for NUP98:
Animal Models:
Mouse knock-outs for NUP98: Nup98tm1Jvd Nup98tm1Bmaf
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Nup98):
NUP98 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NUP98 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus | | | 2 | M Phase | | | 3 | Resolution of Sister Chromatid Cohesion | | | 4 | Cytokine Signaling in Immune system | | | 5 | HIV Infection | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for NUP98
5/33 
Reactome Pathways for NUP98 (see all 33)
2 
Kegg Pathways (Kegg details for NUP98):
NUP98 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUP98
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/51 Interacting proteins for NUP98 (P529482, 3 ENSP000003160324) via UniProtKB, MINT, STRING, and/or I2D (see all 51)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table
NUP98 for ontologies About GeneDecksing
|
Drugs & Compounds
for NUP98 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NUP98 for compounds About GeneDecksing
 Browse Tocris compounds for NUP98
3 Novoseek chemical compound relationships for NUP98 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| deguelin |
72.7 |
8 |
16174445 (4), 17650673 (4) |
| gtp |
15.4 |
1 |
10875935 (1) |
| oligonucleotide |
1.04 |
1 |
19696924 (1) |
Search CenterWatch for drugs/clinical trials and news about NUP98
|
Transcripts
for NUP98 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NUP98 gene (4 alternative transcripts): NM_005387.5 NM_016320.4 NM_139131.3 NM_139132.3 Unigene Cluster for NUP98: Nucleoporin 98kDa Hs.524750 [show with all ESTs]Unigene Representative Sequence: NM_01632018/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000533346 ENST00000324932(uc001lyg.3 uc001lyh.3 uc001lyi.3)
ENST00000355260 ENST00000429801 ENST00000469881 ENST00000482690 ENST00000524563
ENST00000530345 ENST00000488828 ENST00000529063 ENST00000483285 ENST00000397004
ENST00000397007(uc001lyj.2 uc001lyk.2) ENST00000530516 ENST00000527104
ENST00000529379 ENST00000397013 ENST00000461047
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP98 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP98 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): NUP98 (NM_139132) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NUP98 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP98 |
Additional cDNA sequence: AB040538.1 AF071076.1 AF071077.1 AF116074.1 AF231130.1 AK292882.1 AK301512.1 AL133601.1 AL137613.1 BC012906.1 BC041136.1 BT007349.1 U41815.1 24/27 DOTS entries (see all 27): DT.117788 DT.95305850 DT.100745542 DT.91769481 DT.100801254 DT.95305846 DT.97809667 DT.100801237 DT.91769485 DT.92040153 DT.120744135 DT.120744288 DT.120744689 DT.86852639 DT.86853246 DT.91769490 DT.95318918 DT.100739046 DT.120744398 DT.75101527 DT.91769491 DT.91769492 DT.95182995 DT.91731843 24/347 AceView cDNA sequences (see all 347): CA426208 BF056412 AI052679 BQ063272 NM_139131 AA505118 AA628304 CK724964 AL703833 CB159858 CA307636 CK904679 BM676505 AW574828 AW276430 CA418353 BU950167 CO247236 BM713887 CA313022 BQ017277 AI924128 BM023259 BM023551
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NUP98 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | ^ | 33a | · | 33b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 34a | · | 34b | · | 34c | · | 34d |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for NUP98
|
Expression
for NUP98 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NUP98 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGATAATGT
About this image
See NUP98 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUP98
SOURCE GeneReport for Unigene cluster: Hs.524750
SABiosciences Custom PCR Arrays for NUP98
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP98
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NUP98 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP98 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP98 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP98 |
Orthologs
for NUP98 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NUP98 gene from 7/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NUP981 |
nucleoporin 98kDa |
73.45(n)
77.58(a) |
|
430616 XM_428171.3 XP_428171.3 |
lizard
(Anolis carolinensis) |
Reptilia |
NUP986 |
-- |
52(a) |
1 ↔ 1 |
GL343900.1(24448-69540) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.25222 |
Xenopus laevis transcribed sequence with weak similarity more |
75.6(n) |
|
CA972248.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc635932 |
hypothetical protein MGC63593 |
76.59(n) |
|
393658 BC058869.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG101983
Nup981 |
Nucleoporin 981 |
29(a)3
46.34(n)1
38.31(a)1 |
|
428161 NM_142930.21 NP_651187.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SAR31 |
suppressor of auxin resistance 3 |
41.86(n)
30.68(a) |
|
844407 NM_106716.3 NP_178183.2 |
rice
(Oryza sativa) |
Liliopsida |
Os03g01720001 |
hypothetical protein |
42.99(n)
32.56(a) |
|
4331780 NM_001055651.1 NP_001049116.1 |
ENSEMBL Gene Tree for NUP98 (if available)
TreeFam Gene Tree for NUP98 (if available) |
Paralogs
for NUP98 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NUP98 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NUP98 (3692313 - 3819022 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NUP98
2 CNVs: 3833 75519 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP98 |
|
Disorders
/ Diseases
for NUP98 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUP98 for disorders About GeneDecksing
OMIM gene information: 601021
OMIM disorders: --
UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948
Note=A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocationt(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23 Note=A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocationt(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1 Note=A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome.Translocation t(11;20)(p15;q11) with TOP1 Note=A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia(T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1 Note=A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) withintermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) withPSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4
20/35  diseases for NUP98 (see all 35): About MalaCardsacute lymphocytic leukemia beckwith-wiedemann syndrome lymphocytic leukemia leukemia
dna topoisomerase ii adrenocortical carcinoma acute monocytic leukemia myelomonocytic leukemia
monocytic leukemia non-hodgkin lymphoma wilms tumor megakaryoblastic leukemia
acute megakaryoblastic leukemia weaver syndrome myeloid leukemia chronic myelomonocytic leukemia
acute myelomonocytic leukemia breast cancer acute promyelocytic leukemia rhabdomyosarcoma
1 disease from the University of Copenhagen DISEASES database for NUP98:Leukemia 10/16 Novoseek disease relationships for NUP98 gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemogenesis |
84.7 |
13 |
20237156 (2), 15193442 (1), 19380029 (1), 20417862 (1) (see all 9) |
| myelodysplastic syndromes |
72.1 |
10 |
17988990 (2), 11681408 (2), 10830185 (1), 10502319 (1) (see all 8) |
| aml childhood |
72 |
5 |
15951287 (2), 11493482 (1), 15725483 (1), 12353270 (1) |
| aml adult |
67.5 |
2 |
19665072 (1), 12619167 (1) |
| hematologic malignancies |
65.1 |
12 |
16467868 (1), 19665070 (1), 17988990 (1), 12183408 (1) (see all 12) |
| leukemia |
65.1 |
21 |
15390187 (2), 17233820 (2), 16105755 (2), 20233715 (2) (see all 17) |
| t-all |
61.7 |
12 |
12810632 (3), 17233820 (2), 16467868 (1), 10477737 (1) (see all 5) |
| chromosomal aberrations |
58.1 |
6 |
10565304 (1), 10700860 (1), 11850070 (1), 16419055 (1) (see all 6) |
| myeloid leukemia |
54 |
3 |
18604245 (1), 15454493 (1), 16028218 (1) |
| hematopoietic malignancies |
51.9 |
3 |
16467868 (2), 15951287 (1) |
Human Genome Epidemiology (HuGE) Navigator: NUP98 (1 document)
Export disorders for NUP98 gene to outside databases
|
Publications
for NUP98 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NUP98 gene, integrated from 9 sources (see all 208):
(articles sorted by number of sources associating them with NUP98) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PubMed id 11684705)1, 2, 9 Vasu S.... Forbes D.J. (2001)
- Structural constraints on autoprocessing of the human nucleoporin Nup98. (PubMed id 18287282)1, 2, 9 Sun Y. and Guo H.C. (2008)
- NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). (PubMed id 11986249)1, 2, 9 Rosati R.... Mecucci C. (2002)
- The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. (PubMed id 9166830)1, 3, 9 Arai Y....Ohki M. (1997)
- A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. (PubMed id 11493482)1, 2, 9 Jaju R.J....Wainscoat J.S. (2001)
- The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion. (PubMed id 10556215)1, 2, 9 Ahuja H.G.... Aplan P.D. (1999)
- The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. (PubMed id 8563754)1, 2, 9 Borrow J.... Housman D.E. (1996)
- t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. (PubMed id 15725483)1, 2, 9 Morerio C.... Panarello C. (2005)
- The three-dimensional structure of the autoproteolytic, nuclear pore- targeting domain of the human nucleoporin Nup98. (PubMed id 12191480)1, 2, 9 Hodel A.E....Powers M.A. (2002)
- Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. (PubMed id 20498086)1, 2 Ren Y....Hoelz A. (2010)
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External Searches for NUP98 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing NUP98 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing NUP98 gene
(According to HUGE)
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Specialized Databases showing NUP98 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for NUP98 gene:
Search GeneIP for patents involving NUP98
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NUP98 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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