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NUP98 Gene

protein-coding GIFtS: 66

GC11M003652

nucleoporin 98kDa
(Previous name: nucleoporin 98kD )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ADAR2 ^³
ADIR2 ^²
NUP196 ^²
NUP96 ^¹, ²
Nup98-Nup96 ^²
OTTHUMP00000013819 ^²
OTTHUMP00000013967 ^²

Descriptions
GLFG-repeat containing nucleoporin ^²
nucleoporin 98kD ^¹, ²
nucleoporin 98kDa ^²

External Ids
HGNC: 8068¹
Entrez Gene: 4928²
UniProtKB: P52948³
Ensembl: ENSG00000110713⁷

Search outside databases for aliases for NUP98 gene

Previous GC identifers: GC11M004267 GC11M003962 GC11M003655 GC11M003660

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NUP98:

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is

comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD

nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic

cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as

a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies

show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport

substrates. The human gene has been shown to fuse to several genes following chromsome

translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL).

This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important

tumor-suppressor gene region. Alterations in this region have been associated with the

Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung,

ovarian, and breast cancer. Alternative splicing of this gene results in several transcript

variants; however, not all variants have been fully described. [provided by RefSeq]

UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948

Function: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex

(NPC). The repeat domain in Nup98 has a direct role in the transport

Gene Wiki entry for NUP98

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NUP98 gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15

NUP98 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M003652: (about GC identifiers)

Start:	3,652,816 bp from pter
End:	3,775,468 bp from pter
Size:	122,653 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948 (See protein sequence)

Recommended Name: Nuclear pore complex protein Nup98-Nup96 precursor

Size: 1729 amino acids; 187790 Da

Subunit: Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear

pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA

export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with

vesicular stomatitis virus protein M

Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein;

Nucleoplasmic side. Note=Nup96 is localized to the nucleoplasmic side of the nuclear pore complex,

at or near the nucleoplasmic basket

Sequence caution: Sequence=AAF19342.1; Type=Frameshift; Positions=1551;

PDB structures from and Proteopedia :

1KO6 (3D)

2Q5X (3D)

2Q5Y (3D)

Secondary accessions: Q8IUT2 Q8WYB0 Q96E54 Q9H3Q4 Q9NT02 Q9UF57 Q9UHX0 Q9Y6J4 Q9Y6J5

Alternative splicing: 5 isoforms: P52948-1 P52948-2 P52948-3 P52948-4 P52948-5

Post-translational modifications:

Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only,

respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the

interaction with Nup96¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_005378.4 NP_057404.2 NP_624357.1 NP_624358.2

ENSEMBL proteins:

ENSP00000380202 ENSP00000380213 ENSP00000347404 ENSP00000380199 ENSP00000380208 ENSP00000352091

ENSP00000316032

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NUP98)
	Human Recombinant Proteins from Abnova (NUP98)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005643	nuclear pore	NAS	10087256
GO:0005654	nucleoplasm	TAS	7736573
GO:0016020	membrane	IEA	--
GO:0031965	nuclear membrane	IEA	--

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Antibodies for NUP98:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NUP98
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for NUP98
	Antibodies from Abcam (NUP98), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NUP98)
	Novus Biologicals Antibodies for NUP98

Assays for NUP98:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P52948

ProtoNet protein and cluster: P52948

1 Blocks protein family: IPB007230 Nucleoporin autopeptidase

UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948

Domain: Contains G-L-F-G repeats

Similarity: Belongs to the nucleoporin GLFG family

Similarity: Contains 1 peptidase S59 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NUP98)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NUP98)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_139131

Applied Biosystems Silencer® siRNAs for NUP98

Sigma-Aldrich siRNA and siRNA Panels for NUP98

Sigma-Aldrich shRNA for NUP98

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NUP98
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_005387
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_005387
untagged cDNA clones in CMV expression vector (see all 4): NM_005387

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016320

UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948

Function: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex

(NPC). The repeat domain in Nup98 has a direct role in the transport

Genatlas biochemistry entry for NUP98:

nucleoporin,essential component of multiple RNA export pathway,unlikely involved in the nuclear

import of protein,fused with HOX9D in acute myeloid leukemia with translocation t(7;11)

(p15;p15),and with DDX10 in de novo or therapy related myeloid malignancies with HOXD13 in

translocation t(2;11) (q35;p15) with inv11(p15-q22) and with PMX1 in translocation t(1;11)

(q23;p15),with RAP1GDS1 in t(4;11)(q21;p15) in T cell acute lymphocitic leukemia,fused with TOP1

in t(11;20)(p15;q11) in therapy related myelodysplastic syndrome

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nup98):

lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	TAS	7736573
GO:0005515	protein binding	IPI	9348540
GO:0017056	structural constituent of nuclear pore	NAS	9348540

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for NUP98

5/152 Interacting proteins for NUP98 (ENSP00000316032³ P52948^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 152 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SNUPN	ENSP00000360132³	STRING (score=.904) STRING (score=.899)
NXF1	Q9UBU9²	STRING (score=.996) MINT-15768
MOBKL1B	Q9H8S9¹	EBI-295727, EBI-748229
QRICH2	Q9H0J4¹	EBI-295727, EBI-1053637
RAE1	ENSP00000360286³	STRING (score=.999)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000059	protein import into nucleus, docking	NAS	15229283
GO:0006260	DNA replication	IMP	9348540
GO:0006913	nucleocytoplasmic transport	TAS	9348540
GO:0006999	nuclear pore organization	NAS	9348540
GO:0015031	protein transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NUP98
2 Novoseek chemical compound relationships for NUP98 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
deguelin	74.30	8	16174445 (4), 17650673 (4)
gtp	17.65	1	10875935 (1)

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2 PharmGKB drug compound relationships for NUP98 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NUP98)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NUP98)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_139131

Sigma-Aldrich siRNA and siRNA Panels for NUP98

Sigma-Aldrich shRNA for NUP98

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005387 NM_016320 NM_139131 NM_139132

REFSEQ mRNAs for NUP98 gene (4 alternative transcripts):

NM_005387.4 NM_016320.3 NM_139131.2 NM_139132.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005387 NM_016320 NM_139131 NM_139132

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_005387
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_005387
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_005387

Additional cDNA sequence:

AB040538.1 AF071076.1 AF071077.1 AF116074.1 AF231130.1 AK292882.1 AK301512.1 AL133601.1

AL137613.1 BC012906.1 BC041136.1 BT007349.1 CR591489.1 U41815.1

24/27 DOTS entries (see all 27 ):

DT.117788 DT.95305850 DT.100745542 DT.91769481 DT.100801254 DT.97809667 DT.100801237 DT.95305846

DT.91769485 DT.92040153 DT.120744135 DT.120744288 DT.120744689 DT.86852639 DT.86853246 DT.91769490

DT.95318918 DT.100739046 DT.120744398 DT.75101527 DT.91769491 DT.91769492 DT.95182995 DT.91731843

24/347 AceView cDNA sequences (see all 347 ):

AI688252 CA309884 CF529822 BX100390 BQ017277 CA425764 BU740255 BM669479

CA313022 AA911168 AI811431 AA628304 AW296195 BQ063272 BQ009431 BM068860

CB216507 AI741120 AW102986 CF541172 CO247236 AA612909 BG763331 CD369751

highest scoring ESTs for NUP98:

BG773331 BI462442 BI823848 BM828729 BX423204 BX439931 AB040538 AF071076 AF071077 AF231130

Unigene Cluster for NUP98:

Nucleoporin 98kDa

Hs.524750 [show with all ESTs]

Unigene Representative Sequence: NM_016320

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NUP98 (see all 13 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d	·	11e	^	12a	·	12b	^	13	^	14	^	15	^	16a	·	16b	^
SP1:							-																												-		-
SP2:							-																														-
SP3:							-																												-		-
SP4:
SP5:

ExUns:	17a	·	17b	^	18	^	19	^	20	^	21a	·	21b	^	22a	·	22b	^	23	^	24a	·	24b	^	25	^	26	^	27a	·	27b	^	28	^	29a	·	29b	^	30a	·	30b	^	31	^	32a	·	32b	^	33a	·	33b	^
SP1:													-																																-				-
SP2:
SP3:
SP4:																							-																						-				-
SP5:

ExUns:	34a	·	34b	·	34c	·	34d
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for NUP98

7 Ensembl transcripts including schematic representations:

ENST00000397007 ENST00000397018 ENST00000355260 ENST00000397004 ENST00000397013 ENST00000359171

ENST00000324932

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NUP98 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NUP98

¹ / ² / ³

10 probe-sets matching NUP98 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39024_at²^{, 3}	U95-A	1	1.00	1.00	0.88	1.17	AF042357	0.60	1.00	0.82	1
38911_at²^{, 3}	U95-A	1	1.00	1.00	0.74	0.91	U41815	0.80	0.88	0.84	1
88191_at²^{, 3}	U95-E	1	0.75	1.00	0.85	0.92	AA167378	0.60	1.00	0.82	1
210793_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U41815	0.80	0.88	0.84	1
203195_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005387	0.60	1.00	0.82	1
203194_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA527238	0.60	1.00	0.82	1
210793_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203195_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203194_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555789_s_at²	U133Plus2	2	0.82	0.41	--	--	--	--	--	--	--

GeneDecks NUP98 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGATAATGT

SOURCE GeneReport for Unigene cluster: Hs.524750
Expression variation in blood from EXPOLDB for NUP98

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NUP98 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NUP98¹	--	nucleoporin 98kDa	92.27(n) 93.22(a)	476822 XM_534026.2 XP_534026.2
chimpanzee (Pan troglodytes)	NUP98¹	--	nucleoporin 98kDa	99.48(n) 99.44(a)	450971 XM_001158616.1 XP_001158616.1
cow (Bos taurus)	NUP98¹	--	nucleoporin 98kDa	91.84(n) 93.66(a)	540004 XM_590836.3 XP_590836.3
rat (Rattus norvegicus)	Nup98¹	--	nucleoporin 98kDa	88.88(n) 91.43(a)	81738 XM_574504.2 XP_574504.2
mouse (Mus musculus)	Nup98⁵	7 (51.50 cM)	nucleoporin 98	--	BC145071

About this table Species with no ortholog for NUP98

ENSEMBL Gene Tree for NUP98

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NUP98 gene

ENSG00000205578² POM121C² POM121² POM121L2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/704 NCBI SNPs in NUP98 are shown (see all 704 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 174)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs658731^1,2	A,C,F,H,O	3689536(+)	`GCTACC/AAAGAT`	4	--	ng5¹ int¹		5		MN EU EA WA	592
	rs6578411^1,2	A,C,F,H	3652548(+)	`ATTCTA/GTTGGG`	2	--	ng5¹		12		EU EA WA NA	1056
	rs4910818^1,2	A,C,F,H	3777361(+)	`CTACTT/CCTTTG`	4	--	ng3¹		6		EU EA WA NA	598
	rs7116540^1,2	A,C,F,H	3775843(+)	`GGCTTC/TCTAGT`	4	--	ng3¹		8		EU EA WA	830
	rs16929785^1,2	F,H	3689218(+)	`AACCTA/GGAAAC`	4	--	ng5¹ int¹		7		NA EU EA WA	552
	rs35404087^1,2	C,F	3680357(+)	`CAGCTG/CTTCTC`	2	E/Q	mis¹		5		NA EU EA WA	488
--	rs7105207^1,2	A	3775995(+)	`AGCACA/TTTCTT`	4	--	ng3¹ trp³		0	--	--	--	--
--	rs11606192^1,2	H	3777230(+)	`tcccaG/Tctgct`	4	--	ng3¹		4		EU EA WA	412
	rs7124409^1,2	H	3673391(+)	`ATAAAA/TGAAGA`	2	L/H	mis¹ trp³		4		EU EA WA	414
	rs11028957^1,2	H	3653330(+)	`TGGTGT/CTCATG`	2	--	ut3¹ ese³		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for NUP98 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601021

UniProtKB/Swiss-Prot: NUP98_HUMAN, P52948

A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia.

Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23

A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia.

Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1

A chromosomal aberration involving NUP98 is found in a form of therapy-related

myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1

A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic

leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1

A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid

leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB)

subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame

fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4

10/16 Novoseek disease relationships for NUP98 gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemogenesis	83.46	8	15193442 (1), 19380029 (1), 12810632 (1), 17442773 (1) (see all 6)
aml childhood	73.99	5	15951287 (2), 11493482 (1), 15725483 (1), 12353270 (1)
myelodysplastic syndromes	73.79	10	17988990 (2), 11681408 (2), 10830185 (1), 10502319 (1) (see all 8)
hematologic malignancies	65.78	11	16467868 (1), 17988990 (1), 12183408 (1), 16419055 (1) (see all 11)
leukemia	63.81	17	15390187 (2), 17233820 (2), 16105755 (2), 10929031 (1) (see all 14)
t-all	63.75	12	12810632 (3), 17233820 (2), 16467868 (1), 10477737 (1) (see all 5)
aml adult	63.53	1	12619167 (1)
chromosomal aberrations	59.99	6	10565304 (1), 10700860 (1), 11850070 (1), 16419055 (1) (see all 6)
myeloid leukemia	55.89	3	18604245 (1), 15454493 (1), 16028218 (1)
hematopoietic malignancies	54.23	3	16467868 (2), 15951287 (1)

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1 PharmGKB disease relationship for NUP98 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

About this table

Human Genome Epidemiology Navigator: NUP98 (1 document)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/148 PubMed articles for NUP98 gene (see all 148 ):

Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PubMed id 11684705)^{1, 3, 4} Vasu S.... Forbes D.J. (2001)
NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). (PubMed id 11986249)^{1, 3, 4} Rosati R.... Mecucci C. (2002)
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. (PubMed id 9166830)^{1, 2, 3} Arai Y....Ohki M. (1997)
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. (PubMed id 11493482)^{1, 3, 4} Jaju R.J....Wainscoat J.S. (2001)
The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion. (PubMed id 10556215)^{1, 3, 4} Ahuja H.G.... Aplan P.D. (1999)
The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. (PubMed id 8563754)^{1, 3, 4} Borrow J.... Housman D.E. (1996)
t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. (PubMed id 15725483)^{1, 3, 4} Morerio C.... Panarello C. (2005)
The three-dimensional structure of the autoproteolytic, nuclear pore- targeting domain of the human nucleoporin Nup98. (PubMed id 12191480)^{1, 3, 4} Hodel A.E....Powers M.A. (2002)
A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia. (PubMed id 17287853)^{3, 4} Reader J.C.... Ning Y. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4928	HGNC: 8068	AceView: NUP98	Ensembl:ENSG00000110713	euGenes: HUgn4928
ECgene: NUP98	H-InvDB: NUP98

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for NUP98	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NUP98
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NUP98:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NUP98-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NUP98		Antibodies for NUP98
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NUP98		Browse small molecules at Sigma-Aldrich
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	Recombinant Proteins (NUP98)
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Antibodies & Assays for NUP98

	Recombinant Proteins (NUP98)
	Antibodies (NUP98)

Search OriGene for NUP98

Search Tocris compounds for NUP98

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NUP98

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NUP98 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for NUP98

Summaries
for NUP98

Genomic Location
for NUP98

Proteins
for NUP98

Protein Domains/
Families
for NUP98

Gene Function
for NUP98

Pathways & Interactions
for NUP98

Drugs & Compounds
for NUP98

Transcripts
for NUP98

Expression
for NUP98

Orthologs
for NUP98

Paralogs
for NUP98

SNPs/Variants
for NUP98

Disorders & Mutations
for NUP98

Medical News
for NUP98

Publications
for NUP98

Search for NUP98

Genome Databases showing NUP98

Other Databases showing NUP98

Specialized Databases showing NUP98

Licensable Technologies
for NUP98

Services
for NUP98

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NUP98 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor NUP98

Summariesfor NUP98

Genomic Locationfor NUP98

Proteinsfor NUP98

Protein Domains/Familiesfor NUP98

Gene Functionfor NUP98

Pathways & Interactionsfor NUP98

Drugs & Compoundsfor NUP98

Transcriptsfor NUP98

Expression for NUP98

Orthologsfor NUP98

Paralogsfor NUP98

SNPs/Variantsfor NUP98

Disorders & Mutationsfor NUP98

Medical Newsfor NUP98

Publicationsfor NUP98

Search for NUP98

Genome Databases showing NUP98

Other Databases showing NUP98

Specialized Databases showing NUP98

Licensable Technologiesfor NUP98

Servicesfor NUP98

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NUP98

Summaries
for NUP98

Genomic Location
for NUP98

Proteins
for NUP98

Protein Domains/
Families
for NUP98

Gene Function
for NUP98

Pathways & Interactions
for NUP98

Drugs & Compounds
for NUP98

Transcripts
for NUP98

Expression
for NUP98

Orthologs
for NUP98

Paralogs
for NUP98

SNPs/Variants
for NUP98

Disorders & Mutations
for NUP98

Medical News
for NUP98

Publications
for NUP98

Licensable Technologies
for NUP98

Services
for NUP98