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Aliases for NUP93 Gene

Aliases for NUP93 Gene

  • Nucleoporin 93kDa 2 3 5
  • 93 KDa Nucleoporin 3 4
  • Nucleoporin Nup93 3 4
  • KIAA0095 4
  • NPHS12 3
  • NIC96 3

External Ids for NUP93 Gene

Previous GeneCards Identifiers for NUP93 Gene

  • GC16P056540
  • GC16P055322
  • GC16P042633

Summaries for NUP93 Gene

GeneCards Summary for NUP93 Gene

NUP93 (Nucleoporin 93kDa) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for NUP93 Gene

  • Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC.

Gene Wiki entry for NUP93 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP93 Gene

Genomics for NUP93 Gene

Regulatory Elements for NUP93 Gene

Promoters for NUP93 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP93 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP93 Gene

Chromosome:
16
Start:
56,730,105 bp from pter
End:
56,850,286 bp from pter
Size:
120,182 bases
Orientation:
Plus strand

Genomic View for NUP93 Gene

Genes around NUP93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP93 Gene

Proteins for NUP93 Gene

  • Protein details for NUP93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1F7-NUP93_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup93
    Protein Accession:
    Q8N1F7
    Secondary Accessions:
    • B3KPQ8
    • Q14705

    Protein attributes for NUP93 Gene

    Size:
    819 amino acids
    Molecular mass:
    93488 Da
    Quaternary structure:
    • Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not interact with TPR.
    SequenceCaution:
    • Sequence=BAA07680.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP93 Gene

Proteomics data for NUP93 Gene at MOPED

Post-translational modifications for NUP93 Gene

  • Ubiquitination at Lys 59, Lys 141, Lys 243, Lys 349, Lys 359, Lys 370, Lys 417, Lys 611, Lys 619, Lys 627, Lys 660, Lys 664, and Lys 718
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NUP93 Gene

Domains & Families for NUP93 Gene

Gene Families for NUP93 Gene

Protein Domains for NUP93 Gene

Suggested Antigen Peptide Sequences for NUP93 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1F7

UniProtKB/Swiss-Prot:

NUP93_HUMAN :
  • Belongs to the nucleoporin interacting component (NIC) family.
Family:
  • Belongs to the nucleoporin interacting component (NIC) family.
genes like me logo Genes that share domains with NUP93: view

Function for NUP93 Gene

Molecular function for NUP93 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC.
genes like me logo Genes that share phenotypes with NUP93: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP93 Gene

Localization for NUP93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP93 Gene

Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP93 Gene COMPARTMENTS Subcellular localization image for NUP93 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NUP93 Gene

Pathways & Interactions for NUP93 Gene

SuperPathways for NUP93 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 SUMOylation
4 Mitotic Prophase
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with NUP93: view

Pathways by source for NUP93 Gene

Gene Ontology (GO) - Biological Process for NUP93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA --
GO:0006810 transport IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NUP93: view

No data available for SIGNOR curated interactions for NUP93 Gene

Drugs & Compounds for NUP93 Gene

No Compound Related Data Available

Transcripts for NUP93 Gene

Unigene Clusters for NUP93 Gene

Nucleoporin 93kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP93 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: -
SP8: - - - - - -
SP9:
SP10:
SP11: - -
SP12: -

ExUns: 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -
SP11:
SP12:

Relevant External Links for NUP93 Gene

GeneLoc Exon Structure for
NUP93
ECgene alternative splicing isoforms for
NUP93

Expression for NUP93 Gene

mRNA expression in normal human tissues for NUP93 Gene

Protein differential expression in normal tissues from HIPED for NUP93 Gene

This gene is overexpressed in Bone (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP93 Gene



SOURCE GeneReport for Unigene cluster for NUP93 Gene Hs.276878

genes like me logo Genes that share expression patterns with NUP93: view

Protein tissue co-expression partners for NUP93 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP93 Gene

Orthologs for NUP93 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP93 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUP93 35
  • 92.31 (n)
  • 97.92 (a)
NUP93 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP93 35
  • 93.12 (n)
  • 98.17 (a)
NUP93 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup93 35
  • 89.78 (n)
  • 97.68 (a)
Nup93 16
Nup93 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUP93 35
  • 99.35 (n)
  • 99.88 (a)
NUP93 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup93 35
  • 89.95 (n)
  • 97.56 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP93 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP93 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP93 35
  • 80.46 (n)
  • 92.06 (a)
NUP93 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP93 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup93 35
  • 73.91 (n)
  • 85.35 (a)
Str.1879 35
African clawed frog
(Xenopus laevis)
Amphibia dye-prov 35
zebrafish
(Danio rerio)
Actinopterygii dye 35
nup93 35
  • 74.68 (n)
  • 84 (a)
nup93 36
  • 84 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14054 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003459 35
  • 51.6 (n)
  • 41.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7262 35
  • 48.61 (n)
  • 38.48 (a)
CG11092 36
  • 35 (a)
OneToMany
CG7262 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npp-13 35
  • 42.29 (n)
  • 28.66 (a)
npp-13 36
  • 26 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR004W 35
  • 42.61 (n)
  • 30.2 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14191g 35
  • 43.11 (n)
  • 30.1 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIC96 35
  • 41.68 (n)
  • 28.87 (a)
NIC96 36
  • 25 (a)
OneToOne
NIC96 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57350 35
  • 39.8 (n)
  • 27.12 (a)
rice
(Oryza sativa)
Liliopsida Os03g0349000 35
  • 39.59 (n)
  • 24.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01702 35
  • 42.27 (n)
  • 29.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nup97 35
  • 40.97 (n)
  • 28.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
CSA.10781 36
  • 47 (a)
OneToMany
Species with no ortholog for NUP93:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP93 Gene

ENSEMBL:
Gene Tree for NUP93 (if available)
TreeFam:
Gene Tree for NUP93 (if available)

Paralogs for NUP93 Gene

genes like me logo Genes that share paralogs with NUP93: view

No data available for Paralogs for NUP93 Gene

Variants for NUP93 Gene

Sequence variations from dbSNP and Humsavar for NUP93 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs17853288 - 56,833,396(+) CAGAG(G/T)GCTCA reference, missense
rs745298 -- 56,784,329(-) TATTA(C/T)AGGTC intron-variant
rs1347590 -- 56,814,017(+) TACAA(A/C)TTTTA intron-variant
rs1347591 -- 56,834,788(+) GTTAA(A/G)TGCAT intron-variant
rs1561138 -- 56,818,399(+) AGAAA(A/C)AGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP93 Gene

Variant ID Type Subtype PubMed ID
nsv833244 CNV Gain 17160897

Variation tolerance for NUP93 Gene

Residual Variation Intolerance Score: 15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP93 Gene

HapMap Linkage Disequilibrium report
NUP93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP93 Gene

Disorders for NUP93 Gene

Relevant External Links for NUP93

Genetic Association Database (GAD)
NUP93
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP93

No disorders were found for NUP93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP93 Gene

Publications for NUP93 Gene

  1. Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. (PMID: 9348540) Grandi P. … Hurt E. (Mol. Biol. Cell 1997) 2 3 4 23 67
  2. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. (PMID: 9531546) Shah S. … Forbes D. (J. Cell Biol. 1998) 2 3 23
  3. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PMID: 15229283) Krull S. … Cordes V.C. (Mol. Biol. Cell 2004) 3 23
  4. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for NUP93 Gene

Sources for NUP93 Gene

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