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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NUP93 Gene

protein-coding GIFtS: 57
GCID: GC16P056764

nucleoporin 93kDa

Explore 3 diseases affiliated with
NUP93 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nucleoporin 93kDa¹ ²
KIAA0095¹ ³
Nucleoporin Nup93² ³
93 KDa Nucleoporin² ³
NIC96²
Nuclear Pore Complex Protein Nup93²

External Ids:	HGNC: 28958¹	Entrez Gene: 9688²	Ensembl: ENSG00000102900⁷	OMIM: 614351⁵	UniProtKB: Q8N1F7³

Export aliases for NUP93 gene to outside databases

Previous GC identifers: GC16P056540 GC16P055322 GC16P042633

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NUP93_HUMAN, Q8N1F7

Function: Part of the nucleoporin complex; required for correct nuclear pore assembly

Gene Wiki entry for NUP93

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NUP93 gene promoter:
Sox5 p53 ATF-2 FOXO3 Lmo2 FOXO3b CBF-A FOXO3a Hlf CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUP93 promoter sequence

Search SABiosciences Chromatin IP Primers for NUP93

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP93

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q13 HGNC cytogenetic band: 16q13

NUP93 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP93 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P056764: view genomic region (about GC identifiers)

Start:	56,764,017 bp from pter	End:	56,880,792 bp from pter
Size:	116,776 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NUP93_HUMAN, Q8N1F7 (See protein sequence)

Recommended Name: Nuclear pore complex protein Nup93

Size: 819 amino acids; 93488 Da

Subunit: Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155,

NUP205 and lamin B; the interaction with NUP53 is direct

Subcellular location: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein (By similarity).

Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore

Sequence caution: Sequence=BAA07680.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B3KPQ8 Q14705

Alternative splicing: 2 isoforms: Q8N1F7-1 Q8N1F7-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUP93: NX_Q8N1F7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N1F7

NUP93 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001229724.1 NP_001229725.1 NP_055484.3

ENSEMBL proteins:

ENSP00000310668 ENSP00000455230 ENSP00000456264 ENSP00000458101 ENSP00000454587

ENSP00000457902 ENSP00000454285 ENSP00000454935 ENSP00000458039 ENSP00000455210

ENSP00000454844 ENSP00000455181 ENSP00000440235 ENSP00000458078 ENSP00000456196

ENSP00000457907

Reactome Protein details: Q8N1F7
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NUP93 OriGene Protein Over-expression Lysate: NUP93 OriGene Custom Protein Services for NUP93
	GenScript Custom Purified and Recombinant Proteins Services for NUP93
	Novus Biologicals NUP93 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NUP93

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005635	nuclear envelope	TAS	--
GO:0005643	nuclear pore	IDA	15229283
GO:0031965	nuclear membrane	IDA	15229283
GO:0034399	nuclear periphery	IDA	15229283

NUP93 for ontologies About GeneDecksing

NUP93 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals NUP93 Antibodies
	Search for Antibodies for NUP93 at Abcam
	Uscn Antibodies for NUP93
	Search ThermoFisher Antibodies for NUP93

Assay Products for NUP93:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NUP93
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NUP93

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NUP93 for domains About GeneDecksing

1 InterPro domain/family:

IPR007231 Nucleoporin_int_Nup93/Nic96

Graphical View of Domain Structure for InterPro Entry Q8N1F7

ProtoNet protein and cluster: Q8N1F7

1 Blocks protein family: IPB007231 Nucleoporin interacting component

UniProtKB/Swiss-Prot: NUP93_HUMAN, Q8N1F7

Similarity: Belongs to the nucleoporin interacting component (NIC) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NUP93_HUMAN, Q8N1F7

Function: Part of the nucleoporin complex; required for correct nuclear pore assembly

miRNA Products:		miRTarBase miRNAs that target NUP93: hsa-mir-218 (MIRT001059)

		OriGene 3'-UTR Clone: NUP93 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP93
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP93:
		hsa-miR-551b* hsa-miR-888*
		SwitchGear 3'UTR luciferase reporter plasmid: NUP93 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP93 (see all 7) OriGene shRNA RFP: NUP93 OriGene siRNA: NUP93
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP93

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NUP93

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP93 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP93 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NUP93 (NM_014669)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP93
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP93

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NUP93
		Search LifeMap BioReagents cell lines for NUP93

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP93

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0017056	structural constituent of nuclear pore	IMP	15229283

NUP93 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for NUP93:

Decreased viability	Decreased viability of wild-ty	Increased gamma-H2AX phosphory	Nuclear 40S maturation defects
Nuclear 60S biogenesis defects	Nucleoplasmic pre-40S maturati	Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

8/11 pathways (see all 11)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	1.00	Interactions of Vpr with host cellular proteins	0.70
Nuclear import of Rev protein	0.76	Glucose transport	0.57
Vpr-mediated nuclear import of PICs	0.76	Hexose transport	0.55
Regulation of Glucokinase by Glucokinase Regulatory Protein	0.75	ISG15 antiviral mechanism	0.49

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

HIV Infection

HIV Infection

1.00

Host Interactions of HIV factors

0.64

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

5/23 Reactome Pathways for NUP93 (see all 23)

	Antiviral mechanism by IFN-stimulated genes
	Late Phase of HIV Life Cycle
	Metabolism
	Interactions of Rev with host cellular proteins
	Disease

1 Kegg Pathway (Kegg details for NUP93):

RNA transport

NUP93 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NUP93

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/645 Interacting proteins for NUP93 (Q8N1F7^{2, 3} ENSP00000310668⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 645)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AHCTF1	Q8WYP5²^,³, ENSP00000375705⁴	MINT-4301682 I2D: score=1 STRING: ENSP00000375705
NUP155	O75694²^,³, ENSP00000231498⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000231498
RANGAP1	P46060²^,³	MINT-7947479 I2D: score=1
SEH1L	Q96EE3²^,³	MINT-7947479 I2D: score=1
XPO5	Q9HAV4²^,³	MINT-7947479 I2D: score=1

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006810	transport	--	--
GO:0008645	hexose transport	TAS	--
GO:0010827	regulation of glucose transport	TAS	--
GO:0015031	protein transport	IEA	--

NUP93 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUP93
Search CenterWatch for drugs/clinical trials and news about NUP93

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NUP93 gene (3 alternative transcripts):

NM_001242795.1 NM_001242796.1 NM_014669.4

Unigene Cluster for NUP93:

Nucleoporin 93kDa

Hs.276878 [show with all ESTs]

Unigene Representative Sequence: NM_001242795

18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):

ENST00000308159(uc002eka.3) ENST00000563858 ENST00000566315 ENST00000569842

ENST00000569863 ENST00000562496 ENST00000568656 ENST00000566678 ENST00000564887(uc002ekb.3)

ENST00000569595 ENST00000566727 ENST00000567641 ENST00000568283 ENST00000567081

ENST00000542526(uc010vhi.2) ENST00000563437 ENST00000563405 ENST00000563486

miRNA Products:		OriGene 3'-UTR Clone: NUP93 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP93
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate NUP93:
		hsa-miR-551b* hsa-miR-888*
		SwitchGear 3'UTR luciferase reporter plasmid: NUP93 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP93 (see all 7) OriGene shRNA RFP: NUP93 OriGene siRNA: NUP93
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP93

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP93 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP93 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NUP93 (NM_014669)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP93
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP93

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP93 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NUP93
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP93
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP93

Additional cDNA sequence:

AF086282.1 AK056637.1 AK123594.1 AK125165.1 AK292262.1 AK294176.1 BC034346.1 D42085.1

24/32 DOTS entries (see all 32):

DT.92455793 DT.100820791 DT.100820799 DT.446851 DT.95128057 DT.97855785 DT.102840071 DT.95128117

DT.120684870 DT.120685029 DT.100720893 DT.120684793 DT.101976608 DT.100820787 DT.120685027 DT.92455791

DT.100820789 DT.100773447 DT.100820783 DT.100820784 DT.120684751 DT.120684874 DT.120684895 DT.92455808

24/365 AceView cDNA sequences (see all 365):

BU617675 AI948881 NM_014669 CD244279 BI908199 BM768185 AW002065 BM756568

AU132822 CA488865 AU280537 AK123594 BQ637052 AI281906 AA150772 BM756067

BG026683 BM468434 CR612276 BM741174 AA333184 CA944572 Z45400 CD557670

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for NUP93 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	·	11c	·	11d	·	11e	^	12a	·	12b	^	13	^	14	^	15	^	16	^
SP1:									-		-				-						-		-		-		-												-
SP2:																							-		-		-												-
SP3:															-						-		-		-		-												-
SP4:									-		-				-				-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:											-				-						-		-		-		-

ExUns:	17a	·	17b	^	18	^	19a	·	19b	^	20	^	21	^	22	^	23	^	24a	·	24b	^	25	^	26a	·	26b	·	26c	^	27	^	28
SP1:																									-				-
SP2:																									-				-
SP3:
SP4:	-
SP5:

ECgene alternative splicing isoforms for NUP93

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NUP93 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCCACTAG

About this image
See NUP93 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUP93

SOURCE GeneReport for Unigene cluster: Hs.276878

SABiosciences Custom PCR Arrays for NUP93

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP93 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP93
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP93

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP93

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP93 gene from 10/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nup93^{1 , 5}	nucleoporin 93^{1, 5}	89.78(n)¹ 97.68(a)¹		8 (46.40 cM)⁵ 71805¹ NM_172410.2¹ NP_765998.1¹ 94214601⁵
chicken (Gallus gallus)	Aves	NUP93¹	nucleoporin 93kDa	80.42(n) 92.06(a)		415693 XM_001232546.2 XP_001232547.2
lizard (Anolis carolinensis)	Reptilia	NUP93⁶	--	83(a)	1 ↔ 1	GL343675.1(209995-276914)
African clawed frog (Xenopus laevis)	Amphibia	dye-prov²	hypothetical protein MGC53870	78.18(n)		U63919.1
zebrafish (Danio rerio)	Actinopterygii	dye²	dead eye	76.66(n)		30172 NM_130981.1
fruit fly (Drosophila melanogaster)	Insecta	CG7262¹	CG7262	48.44(n) 38.25(a)		41804 NM_142147.3 NP_650404.1
worm (Caenorhabditis elegans)	Secernentea	npp-13¹	Protein NPP-13	42.2(n) 28.62(a)		171774 NM_170819.4 NP_740802.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NIC96(YFR002W)⁴ NIC96¹	Component of the nuclear pore complex, required for more⁴ Nic96p¹	41.26(n)¹ 28.67(a)¹		6(150016-152535)⁴ 850552^{1, 4} NP_116657.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G57350⁶ AT2G41620⁶	nuclear pore complex component Nup93/Nic96 domain-... Nup93/Nic96 nucleoporin interacting component-cont...	18(a) 18(a)	many → 1 many → 1	3(21220387-21225305) 2(17347304-17355084)
rice (Oryza sativa)	Liliopsida	--	nucleoporin interacting component, putative, expre...	17(a)	1 ↔ 1	3(13099042-13108070)

ENSEMBL Gene Tree for NUP93 (if available)
TreeFam Gene Tree for NUP93 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200269825^1,2	C	--	42631347(-)	`GTTAAA/CCNNNN`	1	--	int¹		0	--	--	--	--
rs117604048^1,2	C,F,	--	42631758(+)	`TATAGA/GGAACT`	1	--	int¹		1		NA	120
rs75117461^1,2	F,	--	42633543(+)	`GCCACG/TCCCCT`	1	--	us2k¹		1		WA	118
rs8053846^1,2	C,	--	42634475(+)	`tccctC/Tggtcg`	1	--	us2k¹		3		NA WA	122
rs76299088^1,2	C,F,	--	56762197(+)	`ATTTAT/ACCTTT`	2	--	us2k¹ int¹		4		NA WA EA	244
rs181082579^1,2		--	56762416(+)	`TATTGC/TACAAG`	2	--	us2k¹ int¹		0	--	--	--	--
rs7197684^1,2	C,F,A,H,	--	56762445(+)	`AAAGTG/ACTTTT`	2	--	int¹ us2k¹		2		NS NA	120
rs58687403^1,2	C	--	56762447(+)	`AGTGC-/TTTTTTTT`	2	--	us2k¹ int¹		0	--	--	--	--
rs71149697^1,2	C	--	56762447(+)	`AGTGC-/TTTTTTT`	2	--	int¹ us2k¹		1		NA	2
rs71949454^1,2	C	--	56762447(+)	`AGTGC-/TTTTTTTT`	2	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NUP93 (56764017 - 56880792 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUP93: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NUP93 for disorders           About GeneDecksing

OMIM gene information: 614351    OMIM disorders: --

3 diseases for NUP93:    About MalaCards

myocardial infarction cholesterol hepatitis

Export disorders for NUP93 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NUP93 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with NUP93)

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Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. (PubMed id 9348540)^{1, 2, 3, 9} Grandi P....Hurt E. (1997)
Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. (PubMed id 9531546)^{1, 3, 9} Shah S....Forbes D. (1998)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)^{1, 2} Nagase T....Kotani H. (1995)
Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PubMed id 15703211)^{2, 9} Hawryluk-Gara L.A.... Wozniak R.W. (2005)
Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PubMed id 15229283)^{1, 9} Krull S....Cordes V.C. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9688	HGNC: 28958	AceView: NUP93	Ensembl:ENSG00000102900	euGenes: HUgn9688
ECgene: NUP93	Kegg: 9688	H-InvDB: NUP93

(According to HUGE)
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HUGE: KIAA0095

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NUP93	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NUP93 gene
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Patent Information for NUP93 gene:
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nucleoporin 93kDa

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NUP93 Gene

nucleoporin 93kDa

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