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NUP93 Gene

protein-coding   GIFtS: 61
GCID: GC16P056764

Nucleoporin 93kDa

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoporin 93kDa1 2
Nucleoporin Nup932 3
93 KDa Nucleoporin2 3
NIC962 5
KIAA00953 5
Nuclear Pore Complex Protein Nup932

External Ids:    HGNC: 289581   Entrez Gene: 96882   Ensembl: ENSG000001029007   OMIM: 6143515   UniProtKB: Q8N1F73   

Export aliases for NUP93 gene to outside databases

Previous GC identifers: GC16P056540 GC16P055322 GC16P042633


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUP93 Gene:
NUP93 (nucleoporin 93kDa) is a protein-coding gene. Diseases associated with NUP93 include brain cancer, and myocardial infarction. GO annotations related to this gene include structural constituent of nuclear pore.

UniProtKB/Swiss-Prot: NUP93_HUMAN, Q8N1F7
Function: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but
not NUP153 and TPR, to the NPC

Gene Wiki entry for NUP93 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUP93 gene promoter:
         Sox5   p53   ATF-2   FOXO3   Lmo2   FOXO3b   CBF-A   FOXO3a   Hlf   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP93 promoter sequence
   Search Chromatin IP Primers for NUP93

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP93


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

NUP93 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP93 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056764:  view genomic region     (about GC identifiers)

Start:
56,764,017 bp from pter      End:
56,878,862 bp from pter
Size:
114,846 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUP93_HUMAN, Q8N1F7 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup93  
Size: 819 amino acids; 93488 Da
Subunit: Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and
NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not
interact with TPR
Sequence caution: Sequence=BAA07680.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KPQ8 Q14705
Alternative splicing: 2 isoforms:  Q8N1F7-1   Q8N1F7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUP93: NX_Q8N1F7

Explore proteomics data for NUP93 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59, Lys141, Lys243, Lys349, Lys359, Lys370, Lys417, Lys611, Lys619, Lys627,
                                 Lys660, Lys664, Lys718
  • Modification sites at PhosphoSitePlus

  • See NUP93 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229724.1  NP_001229725.1  NP_055484.3  

    ENSEMBL proteins: 
     ENSP00000310668   ENSP00000455230   ENSP00000456264   ENSP00000458101   ENSP00000454587  
     ENSP00000457902   ENSP00000454285   ENSP00000454935   ENSP00000458039   ENSP00000455210  
     ENSP00000454844   ENSP00000455181   ENSP00000440235   ENSP00000458078   ENSP00000456196  
     ENSP00000457907  
    Reactome Protein details: Q8N1F7

    NUP93 Human Recombinant Protein Products:

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    NUP93 Assay Products:

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    Cloud-Clone Corp. ELISAs for NUP93
    Cloud-Clone Corp. CLIAs for NUP93


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007231 Nucleoporin_int_Nup93/Nic96

    Graphical View of Domain Structure for InterPro Entry Q8N1F7

    ProtoNet protein and cluster: Q8N1F7

    1 Blocks protein domain: IPB007231 Nucleoporin interacting component

    UniProtKB/Swiss-Prot: NUP93_HUMAN, Q8N1F7
    Similarity: Belongs to the nucleoporin interacting component (NIC) family


    NUP93 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUP93_HUMAN, Q8N1F7
    Function: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but
    not NUP153 and TPR, to the NPC

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017056structural constituent of nuclear pore IMP15229283
         
    NUP93 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for NUP93:
     Decreased viability  Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Nuclear 40S maturation defects 
     Nuclear 60S biogenesis defects  Nucleoplasmic pre-40S maturati  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP93
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    miRNA
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    miRTarBase miRNAs that target NUP93:
    hsa-mir-218-5p (MIRT001059), hsa-mir-125b-5p (MIRT046016)

    Block miRNA regulation of human, mouse, rat NUP93 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NUP93:
    hsa-miR-551b* hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidNUP93 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP93

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP93


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUP93_HUMAN, Q8N1F7: Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Nucleus
    membrane; Peripheral membrane protein (By similarity). Note=Localizes at the nuclear basket and at or near the
    nuclear entry to the gated channel of the pore
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope TAS--
    GO:0005643nuclear pore IDA12802065
    GO:0031965nuclear membrane IDA15229283
    GO:0034399nuclear periphery IDA15229283

    NUP93 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUP93 About   (see all 14)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.93
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for NUP93 (see all 6)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear import of Rev protein
    Nuclear Pore Complex (NPC) Disassembly
    Vpr-mediated nuclear import of PICs


    1 Kegg Pathway  (Kegg details for NUP93):
        RNA transport


    NUP93 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUP93
    Interactions:

        Search GeneGlobe Interaction Network for NUP93

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUP93 (Q8N1F72, 3 ENSP000003106684) via UniProtKB, MINT, STRING, and/or I2D (see all 748)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AHCTF1Q8WYP52, 3, ENSP000003757054MINT-4301682 I2D: score=1 STRING: ENSP00000375705
    NUP155O756942, 3, ENSP000002314984MINT-7947479 I2D: score=1 STRING: ENSP00000231498
    RANGAP1P460602, 3, ENSP000003485774MINT-7947479 I2D: score=1 STRING: ENSP00000348577
    YEATS4O956192, 3MINT-7947479 I2D: score=1 
    HIST1H2BCP628073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006810transport ----
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    NUP93 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUP93



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUP93 gene (3 alternative transcripts): 
    NM_001242795.1  NM_001242796.1  NM_014669.4  

    Unigene Cluster for NUP93:

    Nucleoporin 93kDa
    Hs.276878  [show with all ESTs]
    Unigene Representative Sequence: NM_001242795
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000308159(uc002eka.3) ENST00000563858 ENST00000566315 ENST00000569842
    ENST00000569863 ENST00000562496 ENST00000568656 ENST00000566678 ENST00000564887(uc002ekb.3)
    ENST00000569595 ENST00000566727 ENST00000567641 ENST00000568283 ENST00000567081
    ENST00000542526(uc010vhi.2) ENST00000563437 ENST00000563405 ENST00000563486

    miRNA
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    Block miRNA regulation of human, mouse, rat NUP93 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NUP93:
    hsa-miR-551b* hsa-miR-888*
    SwitchGear 3'UTR luciferase reporter plasmidNUP93 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NUP93
    Predesigned siRNA for gene silencing in human, mouse, rat NUP93
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP93 (NM_014669)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP93
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP93
    Primer
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    OriGene qPCR primer pairs and template standards for NUP93
    OriGene qSTAR qPCR primer pairs in human, mouse for NUP93
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUP93
      QuantiTect SYBR Green Assays in human, mouse, rat NUP93
      QuantiFast Probe-based Assays in human, mouse, rat NUP93

    Additional mRNA sequence: 

    AF086282.1 AK056637.1 AK123594.1 AK125165.1 AK292262.1 AK294176.1 BC034346.1 D42085.1 

    Selected DOTS entries (see all 32):

    DT.92455793  DT.100820791  DT.100820799  DT.446851  DT.95128057  DT.97855785  DT.102840071  DT.95128117 
    DT.120684870  DT.120685029  DT.100720893  DT.120684793  DT.101976608  DT.100820787  DT.120685027  DT.92455791 
    DT.100820789  DT.100773447  DT.100820783  DT.100820784  DT.120684751  DT.120684874  DT.120684895  DT.92455808 

    Selected AceView cDNA sequences (see all 365):

    BM784365 AU132003 AU131463 D42085 AU131757 AA429171 BM708619 BQ420274 
    CB116124 BM757935 BU616997 CB216031 CD243223 BC034346 BU617675 BG194212 
    AI948881 CR624290 CA424108 CA424793 BM756864 BM757246 BM713897 CR612078 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUP93 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                          -     -           -                 -     -     -     -                                   -                                       
    SP2:                                                                    -     -     -                                   -                                       
    SP3:                                            -                 -     -     -     -                                   -                                       
    SP4:                          -     -           -           -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                -           -                 -     -     -     -                                                                           

    ExUns: 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28
    SP1:                                                                          -           -               
    SP2:                                                                          -           -               
    SP3:                                                                                                      
    SP4:  -                                                                                                   
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for NUP93

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NUP93 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCACTAG
    NUP93 Expression
    About this image

    NUP93 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUP93 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.276878
        Custom PCR Arrays for NUP93
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    QuantiFast Probe-based Assays in human, mouse, rat NUP93
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP93

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUP93 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup931 , 5 nucleoporin 931, 5 89.78(n)1
    97.68(a)1
      8 (46.40 cM)5
    718051  NM_172410.21  NP_765998.11 
     942146015 
    chicken
    (Gallus gallus)
    Aves NUP931 nucleoporin 93kDa 80.46(n)
    92.06(a)
      415693  NM_001012526.2  NP_001012544.2 
    lizard
    (Anolis carolinensis)
    Reptilia NUP936
    nucleoporin 93kDa
    83(a)
    1 ↔ 1
    GL343675.1(209995-277084)
    African clawed frog
    (Xenopus laevis)
    Amphibia dye-prov2 hypothetical protein MGC53870 78.18(n)    U63919.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dye2 dead eye 76.66(n)   30172  NM_130981.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72621 CG7262 48.61(n)
    38.48(a)
      41804  NM_142147.3  NP_650404.1 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-131 npp-13 42.29(n)
    28.66(a)
      171774  NM_170819.5  NP_740802.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NIC96(YFR002W)4
    NIC961
    Component of the nuclear pore complex, required for more4
    NIC961
    41.68(n)1
    28.87(a)1
      6(150016-152535)4
    8505521, 4  NP_116657.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G573501 AT3G57350 39.8(n)
    27.12(a)
      824902  NM_115595.6  NP_191294.5 
    rice
    (Oryza sativa)
    Liliopsida Os03g03490001 Os03g0349000 39.59(n)
    24.19(a)
      4332834  NM_001056641.1  NP_001050106.1 


    ENSEMBL Gene Tree for NUP93 (if available)
    TreeFam Gene Tree for NUP93 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUP93 gene
    Selected SIMAP similar genes for NUP93 using alignment to 14 protein entries:     NUP93_HUMAN (see all proteins) (see all similar genes):
    ADCK1    ARL6IP5    DYNC2LI1    VPS33A    PFKFB3    SEPSECS
    ZNF799    C1orf143    CDK10    DPP9    COQ5    ATF1
    EEF1E1    NLRC5    ARIH1    ZNF114    RRM2B    BEAN1

    NUP93 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUP93 (see all 2292)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116441591,2
    C,F,H--56766031(+) TTCACT/AAGGGA 1 -- int11Minor allele frequency- A:0.50NA 4
    rs1148180141,2
    F--56766057(+) TTTCCC/GCATTT 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1128310861,2
    F--56766058(+) TTCCCC/TATTTC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1451810671,2
    --56766066(+) TTCCCG/TCCTCC 1 -- int10--------
    rs1509551421,2
    --56766152(+) ATGTGA/GGTGAG 1 -- int10--------
    rs125995451,2
    H--56766202(+) acctaG/Tgtctg 1 -- int10--------
    rs1826855021,2
    C--56766343(+) GCAATA/GAAAGC 1 -- int10--------
    rs1394820701,2
    C--56766488(+) AAGACC/TGTGCA 1 -- int10--------
    rs1153722241,2
    F--56766493(+) CGTGCA/GGTGTG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1496611241,2
    C--56766534(+) CTGAAC/TCAGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for NUP93 (56764017 - 56878862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NUP93:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833244CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUP93
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP93

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614351    OMIM disorders: --

    8 diseases for NUP93:    
    About MalaCards
    brain cancer    myocardial infarction    influenza    hiv-1
    hepatitis    multiple myeloma    myeloma    malaria


    NUP93 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUP93

    Export disorders for NUP93 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUP93 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with NUP93)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. (PubMed id 9348540)1, 2, 3, 9 Grandi P....Hurt E. (Mol. Biol. Cell 1997)
    2. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PubMed id 15229283)1, 2, 9 Krull S.... Cordes V.C. (Mol. Biol. Cell 2004)
    3. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. (PubMed id 9531546)1, 3, 9 Shah S....Forbes D. (J. Cell Biol. 1998)
    4. Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study. (PubMed id 20031564)1, 4 Ridker P.M....Chasman D.I. (Circ Cardiovasc Genet 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. (PubMed id 12802065)1, 2 Hase M.E. and Cordes V.C. (Mol. Biol. Cell 2003)
    8. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    9. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PubMed id 15703211)2, 9 Hawryluk-Gara L.A.... Wozniak R.W. (Mol. Biol. Cell 2005)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9688 HGNC: 28958 AceView: NUP93 Ensembl:ENSG00000102900 euGenes: HUgn9688
    ECgene: NUP93 Kegg: 9688 H-InvDB: NUP93

    (According to HUGE)
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    HUGE: KIAA0095

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUP93 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUP93 gene:
    Search GeneIP for patents involving NUP93

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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