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Aliases for NUP93 Gene

Aliases for NUP93 Gene

  • Nucleoporin 93kDa 2 3
  • 93 KDa Nucleoporin 3 4
  • Nucleoporin Nup93 3 4
  • KIAA0095 4 6
  • NIC96 3 6
  • Nuclear Pore Complex Protein Nup93 3

External Ids for NUP93 Gene

Previous GeneCards Identifiers for NUP93 Gene

  • GC16P056540
  • GC16P055322
  • GC16P042633

Summaries for NUP93 Gene

GeneCards Summary for NUP93 Gene

NUP93 (Nucleoporin 93kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include structural constituent of nuclear pore.

UniProtKB/Swiss-Prot for NUP93 Gene

  • Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC.

Gene Wiki entry for NUP93 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP93 Gene

Genomics for NUP93 Gene

Regulatory Elements for NUP93 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUP93 Gene

Start:
56,730,105 bp from pter
End:
56,850,286 bp from pter
Size:
120,182 bases
Orientation:
Plus strand

Genomic View for NUP93 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP93 Gene

Proteins for NUP93 Gene

  • Protein details for NUP93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1F7-NUP93_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup93
    Protein Accession:
    Q8N1F7
    Secondary Accessions:
    • B3KPQ8
    • Q14705

    Protein attributes for NUP93 Gene

    Size:
    819 amino acids
    Molecular mass:
    93488 Da
    Quaternary structure:
    • Part of the nuclear pore complex (NPC). Component of the p62 complex, a complex composed of NUP62 and NUP54. Forms a complex with NUP53, NUP155, NUP205 and lamin B; the interaction with NUP53 is direct. Does not interact with TPR.
    SequenceCaution:
    • Sequence=BAA07680.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NUP93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP93 Gene

Proteomics data for NUP93 Gene at MOPED

Post-translational modifications for NUP93 Gene

  • Ubiquitination at Lys59, Lys141, Lys243, Lys349, Lys359, Lys370, Lys417, Lys611, Lys619, Lys627, Lys660, Lys664, and Lys718
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NUP93 Gene

Domains for NUP93 Gene

Protein Domains for NUP93 Gene

Suggested Antigen Peptide Sequences for NUP93 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1F7

UniProtKB/Swiss-Prot:

NUP93_HUMAN :
  • Q8N1F7
Family:
  • Belongs to the nucleoporin interacting component (NIC) family.
genes like me logo Genes that share domains with NUP93: view

No data available for Gene Families for NUP93 Gene

Function for NUP93 Gene

Molecular function for NUP93 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC.

Gene Ontology (GO) - Molecular Function for NUP93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017056 structural constituent of nuclear pore IMP 15229283
genes like me logo Genes that share ontologies with NUP93: view
genes like me logo Genes that share phenotypes with NUP93: view

Animal Model Products

CRISPR Products

miRNA for NUP93 Gene

miRTarBase miRNAs that target NUP93

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP93 Gene

Localization for NUP93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP93 Gene

Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Note=Localizes at the nuclear basket and at or near the nuclear entry to the gated channel of the pore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP93 Gene COMPARTMENTS Subcellular localization image for NUP93 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NUP93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IDA 12802065
GO:0016020 membrane IDA 19946888
GO:0031965 nuclear membrane IDA 15229283
GO:0034399 nuclear periphery IDA 15229283
genes like me logo Genes that share ontologies with NUP93: view

Pathways for NUP93 Gene

SuperPathways for NUP93 Gene

genes like me logo Genes that share pathways with NUP93: view

Pathways by source for NUP93 Gene

42 Reactome pathways for NUP93 Gene
1 KEGG pathway for NUP93 Gene

Gene Ontology (GO) - Biological Process for NUP93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0005975 carbohydrate metabolic process TAS --
GO:0006606 protein import into nucleus IBA --
GO:0006810 transport --
genes like me logo Genes that share ontologies with NUP93: view

Transcripts for NUP93 Gene

Unigene Clusters for NUP93 Gene

Nucleoporin 93kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUP93

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP93 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: -
SP8: - - - - - -
SP9:
SP10:
SP11: - -
SP12: -

ExUns: 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -
SP11:
SP12:

Relevant External Links for NUP93 Gene

GeneLoc Exon Structure for
NUP93
ECgene alternative splicing isoforms for
NUP93

Expression for NUP93 Gene

mRNA expression in normal human tissues for NUP93 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP93 Gene

SOURCE GeneReport for Unigene cluster for NUP93 Gene Hs.276878

genes like me logo Genes that share expressions with NUP93: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP93 Gene

Orthologs for NUP93 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP93 35
  • 99.35 (n)
  • 99.88 (a)
NUP93 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUP93 35
  • 92.31 (n)
  • 97.92 (a)
NUP93 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP93 35
  • 93.12 (n)
  • 98.17 (a)
NUP93 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup93 35
  • 89.78 (n)
  • 97.68 (a)
Nup93 16
Nup93 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUP93 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP93 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup93 35
  • 89.95 (n)
  • 97.56 (a)
chicken
(Gallus gallus)
Aves NUP93 35
  • 80.46 (n)
  • 92.06 (a)
NUP93 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP93 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dye-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nup93 35
  • 73.91 (n)
  • 85.35 (a)
Str.1879 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14054 35
zebrafish
(Danio rerio)
Actinopterygii dye 35
nup93 35
  • 74.68 (n)
  • 84 (a)
nup93 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003459 35
  • 51.6 (n)
  • 41.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11092 36
  • 35 (a)
OneToMany
CG7262 35
  • 48.61 (n)
  • 38.48 (a)
CG7262 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npp-13 35
  • 42.29 (n)
  • 28.66 (a)
npp-13 36
  • 26 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR004W 35
  • 42.61 (n)
  • 30.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIC96 35
  • 41.68 (n)
  • 28.87 (a)
NIC96 36
  • 25 (a)
OneToOne
NIC96 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E14191g 35
  • 43.11 (n)
  • 30.1 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57350 35
  • 39.8 (n)
  • 27.12 (a)
rice
(Oryza sativa)
Liliopsida Os03g0349000 35
  • 39.59 (n)
  • 24.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01702 35
  • 42.27 (n)
  • 29.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nup97 35
  • 40.97 (n)
  • 28.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
CSA.10781 36
  • 47 (a)
OneToMany
Species with no ortholog for NUP93:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP93 Gene

ENSEMBL:
Gene Tree for NUP93 (if available)
TreeFam:
Gene Tree for NUP93 (if available)

Paralogs for NUP93 Gene

genes like me logo Genes that share paralogs with NUP93: view

No data available for Paralogs for NUP93 Gene

Variants for NUP93 Gene

Sequence variations from dbSNP and Humsavar for NUP93 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs745298 -- 56,784,329(-) TATTA(C/T)AGGTC intron-variant
rs1053078 -- 56,844,892(+) ATATT(C/G)ATTAT utr-variant-3-prime
rs1138295 -- 56,839,583(+) GCTGC(C/T)TTCAG reference, synonymous-codon
rs1347590 -- 56,814,017(+) TACAA(A/C)TTTTA intron-variant
rs1347591 -- 56,834,788(+) GTTAA(A/G)TGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP93 Gene

Variant ID Type Subtype PubMed ID
nsv833244 CNV Gain 17160897

Relevant External Links for NUP93 Gene

HapMap Linkage Disequilibrium report
NUP93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP93 Gene

Disorders for NUP93 Gene

Relevant External Links for NUP93

Genetic Association Database (GAD)
NUP93
genes like me logo Genes that share disorders with NUP93: view

No data available for UniProtKB/Swiss-Prot for NUP93 Gene

Publications for NUP93 Gene

  1. Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. (PMID: 9348540) Grandi P. … Hurt E. (Mol. Biol. Cell 1997) 2 3 4 23
  2. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. (PMID: 9531546) Shah S. … Forbes D. (J. Cell Biol. 1998) 2 3 23
  3. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. (PMID: 15229283) Krull S. … Cordes V.C. (Mol. Biol. Cell 2004) 3 4 23
  4. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PMID: 15703211) Hawryluk-Gara L.A. … Wozniak R.W. (Mol. Biol. Cell 2005) 4 23
  5. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4

Products for NUP93 Gene

Sources for NUP93 Gene

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