Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUP88 Gene

Aliases for NUP88 Gene

  • Nucleoporin 88 2 3
  • Nucleoporin 88kDa 2 3 5
  • Nucleoporin Nup88 3 4
  • Nuclear Pore Complex Protein 88 3
  • 88 KDa Nucleoporin 4
  • Nucleoporin 88kD 2
  • Karyoporin 3

External Ids for NUP88 Gene

Previous GeneCards Identifiers for NUP88 Gene

  • GC17M005674
  • GC17M005233
  • GC17M005489
  • GC17M005230
  • GC17M005180
  • GC17M005361
  • GC17M005363

Summaries for NUP88 Gene

Entrez Gene Summary for NUP88 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for NUP88 Gene

NUP88 (Nucleoporin 88) is a Protein Coding gene. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include transporter activity.

UniProtKB/Swiss-Prot for NUP88 Gene

  • Essential component of nuclear pore complex.

Gene Wiki entry for NUP88 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP88 Gene

Genomics for NUP88 Gene

Regulatory Elements for NUP88 Gene

Promoters for NUP88 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP88 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUP88 Gene

Chromosome:
17
Start:
5,360,963 bp from pter
End:
5,420,160 bp from pter
Size:
59,198 bases
Orientation:
Minus strand

Genomic View for NUP88 Gene

Genes around NUP88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP88 Gene

Proteins for NUP88 Gene

  • Protein details for NUP88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99567-NUP88_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup88
    Protein Accession:
    Q99567
    Secondary Accessions:
    • D3DTM2
    • Q9BWE5

    Protein attributes for NUP88 Gene

    Size:
    741 amino acids
    Molecular mass:
    83542 Da
    Quaternary structure:
    • Interacts with NUP214/CAN.

neXtProt entry for NUP88 Gene

Proteomics data for NUP88 Gene at MOPED

Post-translational modifications for NUP88 Gene

  • Ubiquitination at Lys 150, Lys 226, Lys 531, and Lys 552
  • Modification sites at PhosphoSitePlus

Other Protein References for NUP88 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NUP88 (NUP88)
  • Cloud-Clone Corp. Antibodies for NUP88

No data available for DME Specific Peptides for NUP88 Gene

Domains & Families for NUP88 Gene

Gene Families for NUP88 Gene

Protein Domains for NUP88 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NUP88 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NUP88: view

No data available for UniProtKB/Swiss-Prot for NUP88 Gene

Function for NUP88 Gene

Molecular function for NUP88 Gene

GENATLAS Biochemistry:
CAN/NUP214 interacting protein 88
UniProtKB/Swiss-Prot Function:
Essential component of nuclear pore complex.
genes like me logo Genes that share phenotypes with NUP88: view

Animal Models for NUP88 Gene

MGI Knock Outs for NUP88:

Animal Model Products

  • Taconic Biosciences Mouse Models for NUP88

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NUP88 Gene

Localization for NUP88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP88 Gene

Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP88 Gene COMPARTMENTS Subcellular localization image for NUP88 gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for NUP88 Gene

Pathways & Interactions for NUP88 Gene

SuperPathways for NUP88 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 SUMOylation
4 Mitotic Prophase
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with NUP88: view

Pathways by source for NUP88 Gene

Gene Ontology (GO) - Biological Process for NUP88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IBA --
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006406 mRNA export from nucleus IBA,TAS --
GO:0006409 tRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with NUP88: view

No data available for SIGNOR curated interactions for NUP88 Gene

Drugs & Compounds for NUP88 Gene

(1) Additional Compounds for NUP88 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NUP88: view

Transcripts for NUP88 Gene

Unigene Clusters for NUP88 Gene

Nucleoporin 88kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP88 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: - - - -
SP7:
SP8: -

Relevant External Links for NUP88 Gene

GeneLoc Exon Structure for
NUP88
ECgene alternative splicing isoforms for
NUP88

Expression for NUP88 Gene

mRNA expression in normal human tissues for NUP88 Gene

Protein differential expression in normal tissues from HIPED for NUP88 Gene

This gene is overexpressed in Lymph node (10.5), Peripheral blood mononuclear cells (8.2), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP88 Gene



SOURCE GeneReport for Unigene cluster for NUP88 Gene Hs.584784

mRNA Expression by UniProt/SwissProt for NUP88 Gene

Q99567-NUP88_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NUP88: view

Protein tissue co-expression partners for NUP88 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NUP88 Gene

Orthologs for NUP88 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP88 36
  • 99 (a)
OneToOne
NUP88 35
  • 99.46 (n)
  • 99.33 (a)
cow
(Bos Taurus)
Mammalia NUP88 35
  • 90.1 (n)
  • 93.12 (a)
NUP88 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP88 36
  • 89 (a)
OneToOne
NUP88 35
  • 82.09 (n)
  • 88.77 (a)
mouse
(Mus musculus)
Mammalia Nup88 16
Nup88 36
  • 89 (a)
OneToOne
Nup88 35
  • 87.07 (n)
  • 90.27 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia NUP88 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup88 35
  • 86.22 (n)
  • 89.86 (a)
chicken
(Gallus gallus)
Aves NUP88 35
  • 72.77 (n)
  • 76.56 (a)
NUP88 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP88 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24356 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nup88 35
  • 65.66 (n)
  • 65.1 (a)
Str.10700 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
nup88 35
  • 63.44 (n)
  • 64.94 (a)
nup88 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001179 35
  • 43.35 (n)
  • 33.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta mbo 36
  • 27 (a)
OneToOne
mbo 37
  • 26 (a)
mbo 35
  • 41.88 (n)
  • 31.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for NUP88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP88 Gene

ENSEMBL:
Gene Tree for NUP88 (if available)
TreeFam:
Gene Tree for NUP88 (if available)

Paralogs for NUP88 Gene

(14) SIMAP similar genes for NUP88 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUP88: view

No data available for Paralogs for NUP88 Gene

Variants for NUP88 Gene

Sequence variations from dbSNP and Humsavar for NUP88 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1806245 - 5,405,235(+) CAATA(C/T)TTCCA reference, missense
rs14231 -- 5,391,656(-) CAGCC(A/T)GCTCC reference, synonymous-codon
rs929262 -- 5,408,951(+) AAAAC(A/G)ACAAA intron-variant
rs1544400 -- 5,402,604(+) TACCA(A/G)AACTA intron-variant
rs1136043 -- 5,394,906(+) ATGGC(C/T)TCGTA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NUP88 Gene

Variant ID Type Subtype PubMed ID
nsv819549 CNV Loss 19587683
nsv819032 CNV Loss 19587683

Variation tolerance for NUP88 Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP88 Gene

HapMap Linkage Disequilibrium report
NUP88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP88 Gene

Disorders for NUP88 Gene

Relevant External Links for NUP88

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP88

No disorders were found for NUP88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP88 Gene

Publications for NUP88 Gene

  1. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88. (PMID: 9049309) Fornerod M. … Grosveld G. (EMBO J. 1997) 2 3 4 67
  2. Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis. (PMID: 19700630) Cheng Y.T. … Li X. (Plant Cell 2009) 3 23
  3. Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes. (PMID: 18068677) Kodiha M. … Stochaj U. (Biochim. Biophys. Acta 2008) 3 23
  4. Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus. (PMID: 18606815) Andres-Hernando A. … Berl T. (J. Biol. Chem. 2008) 3 23
  5. [Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro]. (PMID: 17650673) Chen Y. … Chen W.H. (Zhonghua Xue Ye Xue Za Zhi 2007) 3 23

Products for NUP88 Gene

Sources for NUP88 Gene

Back to Top

Content