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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUP88 Gene

protein-coding   GIFtS: 60
GCID: GC17M005180

Nucleoporin 88kDa

(Previous name: nucleoporin 88kD)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleoporin 88kDa1 2     karyoporin2
Nucleoporin Nup882 3     Nuclear Pore Complex Protein 882
88 KDa Nucleoporin2 3     Nuclear Pore Complex Protein Nup882
Nucleoporin 88kD1     

External Ids:    HGNC: 80671   Entrez Gene: 49272   Ensembl: ENSG000001085597   OMIM: 6025525   UniProtKB: Q995673   

Export aliases for NUP88 gene to outside databases

Previous GC identifers: GC17M005674 GC17M005233 GC17M005489 GC17M005230


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUP88 Gene:
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that
regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100
proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this
gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic
subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous
dysplasias. (provided by RefSeq, Jul 2008)

GeneCards Summary for NUP88 Gene: 
NUP88 (nucleoporin 88kDa) is a protein-coding gene. Diseases associated with NUP88 include oral squamous cell carcinoma, and endometrial carcinoma, and among its related super-pathways are Interactions of Rev with host cellular proteins and HIV Life Cycle. GO annotations related to this gene include transporter activity.

UniProtKB/Swiss-Prot: NUP88_HUMAN, Q99567
Function: Essential component of nuclear pore complex

Gene Wiki entry for NUP88 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUP88 gene promoter:
         AhR   SRF   FOXF2   SRF (504 AA)   CUTL1   Arnt   HEN1   Pax-3   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP88 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUP88

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP88


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

NUP88 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP88 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M005180:  view genomic region     (about GC identifiers)

Start:
5,264,258 bp from pter      End:
5,323,480 bp from pter
Size:
59,223 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUP88_HUMAN, Q99567 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup88  
Size: 741 amino acids; 83542 Da
Subunit: Interacts with NUP214/CAN
Subcellular location: Nucleus, nuclear pore complex
Secondary accessions: D3DTM2 Q9BWE5

Explore the universe of human proteins at neXtProt for NUP88: NX_Q99567

Explore proteomics data for NUP88 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99567

  • NUP88 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUP88 Protein Expression
    REFSEQ proteins: NP_002523.2  
    ENSEMBL proteins: 
     ENSP00000461334   ENSP00000458954   ENSP00000225696   ENSP00000459370   ENSP00000459979  
    Reactome Protein details: Q99567
    Human Recombinant Protein Products for NUP88: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUP88 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005643nuclear pore IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    NUP88 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019321 Nucleoporin_Nup88

    Graphical View of Domain Structure for InterPro Entry Q99567

    ProtoNet protein and cluster: Q99567


    NUP88 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUP88_HUMAN, Q99567
    Function: Essential component of nuclear pore complex

         Genatlas biochemistry entry for NUP88:
    CAN/NUP214 interacting protein 88

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9049309
         
    NUP88 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for NUP88:
     Decreased TP53 protein express  Increased circadian period len  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects 
     Nucleoplasmic pre-40S maturati 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nup88):
     behavior/neurological  other 

    NUP88 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUP88 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUP88

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP88 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUP88 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP88


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUP88 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.94
    Hexose transport0.87
    Nuclear import of Rev protein0.94
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.82
    Interactions of Rev with host cellular proteins0.94
    Nuclear Pore Complex (NPC) Disassembly0.77
    Vpr-mediated nuclear import of PICs0.91
    Nuclear Envelope Breakdown0.77
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    4M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/29        Reactome Pathways for NUP88 (see all 29)
        Antiviral mechanism by IFN-stimulated genes
    Late Phase of HIV Life Cycle
    Metabolism
    Cell Cycle
    M Phase


    1         Kegg Pathway  (Kegg details for NUP88):
        RNA transport


    NUP88 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUP88

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/85 Interacting proteins for NUP88 (Q995672, 3 ENSP000002256964) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUP214P356583, ENSP000003524004I2D: score=3 STRING: ENSP00000352400
    NUP98P529483, ENSP000003160324I2D: score=3 STRING: ENSP00000316032
    CD82P277013, ENSP000002271554I2D: score=2 STRING: ENSP00000227155
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    RAE1P784063, ENSP000003602864I2D: score=1 STRING: ENSP00000360286
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--
    GO:0010827regulation of glucose transport TAS--

    NUP88 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NUP88 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUP88

    1 Novoseek inferred chemical compound relationship for NUP88 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deguelin 89.8 11 16174445 (4), 17650673 (3), 18175937 (2)

    Search CenterWatch for drugs/clinical trials and news about NUP88

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUP88 gene: 
    NM_002532.4  

    Unigene Cluster for NUP88:

    Nucleoporin 88kDa
    Hs.584784  [show with all ESTs]
    Unigene Representative Sequence: NM_002532
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000573169(uc002gbn.3) ENST00000576708 ENST00000573584(uc002gbo.2 uc010vsx.2 uc010cle.2)
    ENST00000225696 ENST00000574855 ENST00000574087 ENST00000576862 ENST00000575976
    ENST00000574867(uc010vsy.2) ENST00000570937 ENST00000572809 ENST00000572290
    ENST00000572019
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate NUP88:
    hsa-miR-340
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NUP88
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP88
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP88
    Sirion Biotech Customized lentivirus for stable overexpression of NUP88 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP88

    Additional mRNA sequence: 

    AK225247.1 AK298158.1 AK299000.1 AK308142.1 BC000335.2 Y08612.2 

    24/35 DOTS entries (see all 35):

    DT.100880026  DT.91771986  DT.97864145  DT.453810  DT.100880014  DT.120977655  DT.97770175  DT.91771993 
    DT.119229  DT.91771981  DT.91771980  DT.100815238  DT.100880013  DT.120977918  DT.91771989  DT.120977778 
    DT.318474  DT.99939415  DT.120977812  DT.91771994  DT.97779538  DT.100834676  DT.100880015  DT.100880030 

    24/426 AceView cDNA sequences (see all 426):

    AA668878 AI034324 BM834425 BI259679 CB158519 AI800252 AA312496 CB154288 
    AA491017 AV654439 BE902758 CB990577 AW268632 Z28661 BU858009 AI017198 
    BE706772 BQ182096 BU558277 NM_002532 AW881168 AA426446 AA425331 AA402618 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NUP88 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:              -     -     -                                                                             -                                                   
    SP2:                                                                                                        -     -                                             
    SP3:                                                                                            -           -                                                   
    SP4:                                                                                                        -                                                   
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for NUP88

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUP88 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAACTTCTG
    NUP88 Expression
    About this image


    See NUP88 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUP88

    SOURCE GeneReport for Unigene cluster: Hs.584784

    UniProtKB/Swiss-Prot: NUP88_HUMAN, Q99567
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for NUP88
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP88

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NUP88 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup881 , 5 nucleoporin 881, 5 87.07(n)1
    90.27(a)1
      11 (43.21 cM)5
    190691  NM_172394.21  NP_765982.21 
     709430585 
    chicken
    (Gallus gallus)
    Aves NUP881 nucleoporin 88kDa 73.09(n)
    77.25(a)
      417501  XM_003642421.1  XP_003642469.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUP886
    Uncharacterized protein
    74(a)
    1 ↔ 1
    GL343613.1(366642-382281)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243562 Xenopus laevis transcribed sequence with weak similarity more 74.04(n)    48015160 
    zebrafish
    (Danio rerio)
    Actinopterygii CD053189.12   -- 72.63(n)   337831  CD053189.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mbo1 , 3 antimicrobial humoral response (sensu
    Invertebrata)3
    members only1
    26(a)3
    41.94(n)1
    31.46(a)1
      87C53
    415621  NM_079606.31  NP_524330.21 


    ENSEMBL Gene Tree for NUP88 (if available)
    TreeFam Gene Tree for NUP88 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUP88 gene
    14 SIMAP similar genes for NUP88 using alignment to 5 protein entries:     NUP88_HUMAN (see all proteins):
    ZNF738    ZNF564    ZNF83    FKBP3    AURA2    ZNF212
    CHID1    ZNF737    RNF217    NF2    TCF4    ZNF28
    DCTN5    ZNF74

    NUP88 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/898 SNPs in NUP88 are shown (see all 898)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719215861,2
    C--5289225(+) TAACT-/AACT  
            
    TGCTC
    1 -- ds50010--------
    rs18062221,2
    C,F,O--5289676(+) TGAAAT/CATCTA 1 -- int114Minor allele frequency- C:0.46NA WA CSA EA 514
    rs1420116421,2
    --5289713(+) TGAAGC/GTTTCA 1 -- int10--------
    rs1459056511,2
    --5289762(+) CAAACA/GGTGCA 1 -- int10--------
    rs1176427111,2
    F--5289820(+) CACACA/CACAAA 1 -- int11Minor allele frequency- C:0.01EA 120
    rs610750071,2
    C--5289867(+) CACCA-/TAGTCAT 1 -- int10--------
    rs1929708991,2
    --5289962(+) CAGGTA/TGATTC 1 -- int10--------
    rs610049061,2
    C,F--5289999(+) TCACGA/GTAATA 1 -- int13Minor allele frequency- G:0.01WA EU 1443
    rs10717051,2
    C,F--5290033(+) TCCTCT/CTTCAG 2 /K syn1 ese3 trp320Minor allele frequency- C:0.41MN NA NS WA CSA EA EU 6700
    rs2005348941,2
    C--5290041(+) CAGGAT/GGGACT 2 /I /L mis11Minor allele frequency- G:0.00EU 1323

    HapMap Linkage Disequilibrium report for NUP88 (5264258 - 5323480 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NUP88:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819549CNV Loss19587683
    nsv819032CNV Loss19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602552    OMIM disorders: --

    10 diseases for NUP88:    About MalaCards
    oral squamous cell carcinoma    endometrial carcinoma    liver disease    squamous cell carcinoma
    influenza    hepatitis b    colorectal cancer    hepatitis
    breast cancer    leukemia


    NUP88 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for NUP88 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aggressiveness 37.6 3 14999780 (1), 12759533 (1)
    tumors 14.6 10 12759533 (3), 18621024 (2), 14999780 (1), 15300515 (1) (see all 6)
    leukemia 4.93 2 16174445 (1), 17650673 (1)
    cancer 0 3 18621024 (2), 11073820 (1)


    Export disorders for NUP88 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUP88 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with NUP88)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88. (PubMed id 9049309)1, 2, 3 Fornerod M.... Grosveld G. (1997)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus. (PubMed id 18606815)1, 9 Andres-Hernando A....Berl T. (2008)
    6. Effects of gambogic acid on the regulation of nucleoporin Nup88 in U937 cells. (PubMed id 17828493)1, 9 Shu W....Cui G. (2007)
    7. Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer. (PubMed id 14999780)1, 9 Agudo D....Schneider J. (2004)
    8. [Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro] (PubMed id 17650673)1, 9 Chen Y....Chen W.H. (2007)
    9. Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes. (PubMed id 18068677)1, 9 Kodiha M....Stochaj U. (2008)
    10. A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development. (PubMed id 11073820)1, 9 Gould V.E....Alonso A. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4927 HGNC: 8067 AceView: NUP88 Ensembl:ENSG00000108559 euGenes: HUgn4927
    ECgene: NUP88 Kegg: 4927 H-InvDB: NUP88

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUP88 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NUP88 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUP88 gene:
    Search GeneIP for patents involving NUP88

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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