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Aliases for NUP88 Gene

Aliases for NUP88 Gene

  • Nucleoporin 88kDa 2 3
  • 88 KDa Nucleoporin 3 4
  • Nucleoporin Nup88 3 4
  • Nucleoporin 88kD 2 3
  • Nuclear Pore Complex Protein Nup88 3
  • Nuclear Pore Complex Protein 88 3
  • Karyoporin 3

External Ids for NUP88 Gene

Summaries for NUP88 Gene

Entrez Gene Summary for NUP88 Gene

  • The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP88 Gene

NUP88 (Nucleoporin 88kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include transporter activity.

UniProtKB/Swiss-Prot for NUP88 Gene

  • Essential component of nuclear pore complex

Gene Wiki entry for NUP88 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP88 Gene

Genomics for NUP88 Gene

Genomic Location for NUP88 Gene

Start:
5,360,963 bp from pter
End:
5,420,160 bp from pter
Size:
59,198 bases
Orientation:
Minus strand

Genomic View for NUP88 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP88 Gene

Regulatory Elements for NUP88 Gene

Proteins for NUP88 Gene

  • Protein details for NUP88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99567-NUP88_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup88
    Protein Accession:
    Q99567
    Secondary Accessions:
    • D3DTM2
    • Q9BWE5

    Protein attributes for NUP88 Gene

    Size:
    741 amino acids
    Molecular mass:
    83542 Da
    Quaternary structure:
    • Interacts with NUP214/CAN.

neXtProt entry for NUP88 Gene

Proteomics data for NUP88 Gene at MOPED

Post-translational modifications for NUP88 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys150, Lys226, Lys531, and Lys552

Other Protein References for NUP88 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP88 Gene

Domains for NUP88 Gene

Protein Domains for NUP88 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with NUP88: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NUP88 Gene

Function for NUP88 Gene

Molecular function for NUP88 Gene

GENATLAS Biochemistry: CAN/NUP214 interacting protein 88
UniProtKB/Swiss-Prot Function: Essential component of nuclear pore complex

Gene Ontology (GO) - Molecular Function for NUP88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9049309
genes like me logo Genes that share ontologies with NUP88: view
genes like me logo Genes that share phenotypes with NUP88: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NUP88 Gene

Localization for NUP88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP88 Gene

Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP88 Gene COMPARTMENTS Subcellular localization image for NUP88 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NUP88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005643 nuclear pore IDA 23777819
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUP88: view

Pathways for NUP88 Gene

SuperPathways for NUP88 Gene

genes like me logo Genes that share pathways with NUP88: view

Pathways by source for NUP88 Gene

42 Reactome pathways for NUP88 Gene
1 KEGG pathway for NUP88 Gene

Gene Ontology (GO) - Biological Process for NUP88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008645 hexose transport TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NUP88: view

Compounds for NUP88 Gene

(1) Novoseek inferred chemical compound relationships for NUP88 Gene

Compound -log(P) Hits PubMed IDs
deguelin 89.8 9
genes like me logo Genes that share compounds with NUP88: view

Transcripts for NUP88 Gene

Unigene Clusters for NUP88 Gene

Nucleoporin 88kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP88 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: - - - -
SP7:
SP8: -

Relevant External Links for NUP88 Gene

GeneLoc Exon Structure for
NUP88
ECgene alternative splicing isoforms for
NUP88

Expression for NUP88 Gene

mRNA expression in normal human tissues for NUP88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP88 Gene

SOURCE GeneReport for Unigene cluster for NUP88 Gene Hs.584784

mRNA Expression by UniProt/SwissProt for NUP88 Gene

Q99567-NUP88_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with NUP88: view

Orthologs for NUP88 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP88 36
  • 99.46 (n)
  • 99.33 (a)
NUP88 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUP88 36
  • 90.1 (n)
  • 93.12 (a)
NUP88 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP88 36
  • 82.09 (n)
  • 88.77 (a)
NUP88 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup88 36
  • 87.07 (n)
  • 90.27 (a)
Nup88 16
Nup88 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP88 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup88 36
  • 86.22 (n)
  • 89.86 (a)
chicken
(Gallus gallus)
Aves NUP88 36
  • 72.77 (n)
  • 76.56 (a)
NUP88 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP88 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24356 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nup88 36
  • 65.66 (n)
  • 65.1 (a)
Str.10700 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
nup88 36
  • 63.44 (n)
  • 64.94 (a)
nup88 37
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001179 36
  • 43.35 (n)
  • 33.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta mbo 36
  • 41.88 (n)
  • 31.69 (a)
mbo 37
  • 27 (a)
OneToOne
mbo 38
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for NUP88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP88 Gene

ENSEMBL:
Gene Tree for NUP88 (if available)
TreeFam:
Gene Tree for NUP88 (if available)

Paralogs for NUP88 Gene

Selected SIMAP similar genes for NUP88 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NUP88: view

No data available for Paralogs for NUP88 Gene

Variants for NUP88 Gene

Sequence variations from dbSNP and Humsavar for NUP88 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14231 -- 5,391,656(-) CAGCC(A/T)GCTCC reference, synonymous-codon
rs739766 -- 5,387,279(+) GCAGG(A/G)GGATC intron-variant
rs739767 -- 5,387,361(+) AGGTA(A/C)CTAAA intron-variant
rs739768 -- 5,387,383(+) CCACT(A/G)ACCTG intron-variant
rs748486 -- 5,387,504(+) TCCAC(A/C)CCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP88 Gene

Variant ID Type Subtype PubMed ID
nsv819549 CNV Loss 19587683
nsv819032 CNV Loss 19587683

Relevant External Links for NUP88 Gene

HapMap Linkage Disequilibrium report
NUP88

Disorders for NUP88 Gene

(4) Novoseek inferred disease relationships for NUP88 Gene

Disease -log(P) Hits PubMed IDs
aggressiveness 37.6 2
tumors 14.6 9
leukemia 4.93 2
cancer 0 3
genes like me logo Genes that share disorders with NUP88: view

No data available for UniProtKB/Swiss-Prot for NUP88 Gene

Publications for NUP88 Gene

  1. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and the novel nuclear pore component Nup88. (PMID: 9049309) Fornerod M. … Grosveld G. (EMBO J. 1997) 2 3 4
  2. Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis. (PMID: 19700630) Cheng Y.T. … Li X. (Plant Cell 2009) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  5. Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis. (PMID: 9488438) Boer J. … Grosveld G. (Mol. Cell. Biol. 1998) 3 23

Products for NUP88 Gene

Sources for NUP88 Gene

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