Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUP85 Gene

protein-coding   GIFtS: 55
GCID: GC17P073201

nucleoporin 85kDa

 Explore 1 disease affiliated with
NUP85 via our new
 Human Malady Compendium 
Biological research products
for NUP85
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Nucleoporin 85kDa1 2     Nup752
NUP751 3     Frount1
Nucleoporin Nup752 3     Nuclear Pore Complex Protein Nup852
Nucleoporin Nup852 3     Pericentrin-13
85 KDa Nucleoporin2 3     FROUNT3
PCNT13 5     Pericentrin-13
FLJ125491     PCNT5

External Ids:    HGNC: 87341   Entrez Gene: 799022   Ensembl: ENSG000001254507   OMIM: 1702855   UniProtKB: Q9BW273   

Export aliases for NUP85 gene to outside databases

Previous GC identifers: GC17P070716 GC17P068611


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUP85:
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes
(NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex,
Nup107-160. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27
Function: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and
maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and
NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is
required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes
and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade

Gene Wiki entry for NUP85


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUP85 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP85 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUP85

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP85


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

NUP85 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP85 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073201:  view genomic region     (about GC identifiers)

Start:
73,201,597 bp from pter      End:
73,231,854 bp from pter
Size:
30,258 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup85  
Size: 656 amino acids; 75019 Da
Subunit: Component of the nuclear pore complex (NPC). Component of the NPC Nup107-160 subcomplex, consisting of at
least NUP107, NUP98/Nup96, NUP160, NUP133, NUP85, NUP37, NUP43 and SEC13. Interacts with NUP160, NUP133 and SEC13.
Interacts with NUP37, NUP107 and NUP43. Interacts with CCR2
Subcellular location: Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton,
spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon CCl2
stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells
Sequence caution: Sequence=CAD38749.1; Type=Erroneous initiation;
Secondary accessions: Q8NDI4 Q9H9U1

Explore the universe of human proteins at neXtProt for NUP85: NX_Q9BW27

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BW27

  • NUP85 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079120.1  
    ENSEMBL proteins: 
     ENSP00000462487   ENSP00000245544   ENSP00000463382   ENSP00000462749   ENSP00000461919  
     ENSP00000462920   ENSP00000463715   ENSP00000463496   ENSP00000463542   ENSP00000463377  
     ENSP00000445855   ENSP00000463437   ENSP00000464544   ENSP00000462364   ENSP00000464433  
     ENSP00000441762   ENSP00000408261  
    Reactome Protein details: Q9BW27
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NUP85
    OriGene Custom Protein Services for NUP85 
    GenScript Custom Purified and Recombinant Proteins Services for NUP85
    Novus Biologicals NUP85 Protein
    Novus Biologicals NUP85 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NUP85

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776colocalizes with kinetochore IDA15146057
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005635nuclear envelope TAS--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--


    NUP85 for ontologies           About GeneDecksing



    NUP85 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NUP85 (Nucleoporin NUP85)
    OriGene Antibodies: NUP85
    OriGene Custom Antibody Services for NUP85 
    GenScript Custom Superior Antibodies Services for NUP85
    Novus Biologicals NUP85 Antibodies
    Search for Antibodies for NUP85 at Abcam  
    Uscn Antibodies for NUP85
    ThermoFisher Antibodies for NUP85

    Assay Products for NUP85: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUP85
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NUP85


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NUP85 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011502 Nucleoporin_Nup85

    Graphical View of Domain Structure for InterPro Entry Q9BW27

    ProtoNet protein and cluster: Q9BW27

    UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27
    Similarity: Belongs to the nucleoporin Nup85 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27
    Function: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and
    maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and
    NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is
    required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes
    and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: NUP85
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP85
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NUP85
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP85 (see all 7)
    OriGene shRNA RFP: NUP85
    OriGene siRNA: NUP85
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP85

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NUP85

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP85 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP85
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NUP85 (NM_024844)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP85
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP85 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NUP85
    Search LifeMap BioReagents cell lines for NUP85

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP85

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15146057


    NUP85 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for NUP85:
     Decreased p24 protein expressi  Increased gamma-H2AX phosphory  Nuclear pre-40S maturation def 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    8/11 pathways (see all 11)
    Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus1.00
    Interactions of Vpr with host cellular proteins0.70
    Nuclear import of Rev protein0.76
    Glucose transport0.57
    Vpr-mediated nuclear import of PICs0.76
    Hexose transport0.55
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.75
    ISG15 antiviral mechanism0.49
    2M Phase
    M Phase1.00
    Mitotic Anaphase0.85
    Mitotic M-M/G1 phases0.88
    Separation of Sister Chromatids0.80
    Mitotic Metaphase and Anaphase0.85
    3Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion1.00
    Mitotic Prometaphase0.93
    Kinetochore assembly0.96
    4Cytokine Signaling in Immune system
    Cytokine Signaling in Immune system1.00
    Interferon Signaling0.61
    5HIV Infection
    HIV Infection1.00
    Host Interactions of HIV factors0.64

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for NUP85 
        Integrated Breast Cancer Pathway

    5/33        Reactome Pathways for NUP85 (see all 33)
        Mitotic Prometaphase
    Interactions of Rev with host cellular proteins
    Rev-mediated nuclear export of HIV-1 RNA
    Interferon Signaling
    Vpr-mediated nuclear import of PICs


    1         Kegg Pathway  (Kegg details for NUP85):
        RNA transport


    NUP85 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUP85

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/139 Interacting proteins for NUP85 (Q9BW272, 3 ENSP000002455444) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266412, 3MINT-65375 I2D: score=5 
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    DYNC1LI1Q9Y6G93, ENSP000002731304I2D: score=1 STRING: ENSP00000273130
    NUP107P577403, ENSP000002291794I2D: score=1 STRING: ENSP00000229179
    NUP43Q8NFH33, ENSP000003422624I2D: score=1 STRING: ENSP00000342262
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006935chemotaxis ----


    NUP85 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUP85
    Search CenterWatch for drugs/clinical trials and news about NUP85 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUP85 gene: 
    NM_024844.3  

    Unigene Cluster for NUP85:

    Nucleoporin 85kDa
    Hs.362817  [show with all ESTs]
    Unigene Representative Sequence: NM_024844
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000583569 ENST00000583948 ENST00000245544(uc002jng.1 uc010wrv.1)
    ENST00000582833 ENST00000579324 ENST00000449421 ENST00000577208 ENST00000583548
    ENST00000579298 ENST00000581104 ENST00000578830 ENST00000583877 ENST00000577561
    ENST00000579557 ENST00000577645 ENST00000583070 ENST00000580879 ENST00000581335


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: NUP85
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP85
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NUP85
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP85 (see all 7)
    OriGene shRNA RFP: NUP85
    OriGene siRNA: NUP85
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP85
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP85 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP85
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NUP85 (NM_024844)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP85
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP85 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP85
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUP85
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP85
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP85

    Additional cDNA sequence: 

    AF498261.1 AF514995.1 AK022611.1 AK124501.1 AK295694.1 AK297574.1 AK298519.1 AK302426.1 
    AL833893.1 BC000697.2 

    19 DOTS entries:

    DT.444220  DT.100816167  DT.95353340  DT.100816177  DT.95353339  DT.40108066  DT.95353342  DT.100816170 
    DT.120979202  DT.120979186  DT.97854685  DT.100753625  DT.120979179  DT.75130986  DT.91676126  DT.91764338 
    DT.95353341  DT.99929007  DT.99968516 

    24/354 AceView cDNA sequences (see all 354):

    CF995675 BI906138 BM924988 AA400664 BQ218862 AA776958 AI271569 BM823992 
    BI757463 AI096409 CB161022 CR614721 BM831704 AA315316 BF195124 AA425086 
    BX462224 BE294950 CA487311 BU943486 BM825777 BQ651621 AL560706 BQ063852 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUP85 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
    SP1:                                                                                                        -                                                   
    SP2:              -                                                                                                                                             
    SP3:                                                                                      -           -     -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for NUP85

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUP85 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAATCTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NUP85 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUP85

    SOURCE GeneReport for Unigene cluster: Hs.362817
        SABiosciences Custom PCR Arrays for NUP85
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP85
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUP85
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP85
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP85
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP85

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUP85 gene from 9/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup851 , 5 nucleoporin 851, 5 86.48(n)1
    91.62(a)1
      11 (80.87 cM)5
    4450071  NM_001002929.41  NP_001002929.31 
     1155644345 
    chicken
    (Gallus gallus)
    Aves NUP851 nucleoporin 85kDa 72.09(n)
    74.19(a)
      422120  NM_001006426.1  NP_001006426.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUP856
    --
    76(a)
    1 ↔ 1
    2(114703986-114729270)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146182 Xenopus laevis transcribed sequence with moderate similarity more 74.51(n)    BJ062967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570616392   -- 72.72(n)    57061639 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nup751 Nucleoporin 75 45.11(n)
    33.84(a)
      37078  NM_137456.2  NP_611300.2 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-21 Protein NPP-2 37.4(n)
    24.18(a)
      172611  NM_059855.3  NP_492256.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G329101 hypothetical protein 40.81(n)
    27.88(a)
      829427  NM_119444.3  NP_567908.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07462001 hypothetical protein 40.53(n)
    28.31(a)
      4326176  NM_001050763.1  NP_001044228.1 


    ENSEMBL Gene Tree for NUP85 (if available)
    TreeFam Gene Tree for NUP85 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/697 NCBI SNPs in NUP85 are shown (see all 697    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815398301,2
    --73199611(+) CTCCAC/TTCCAG 1 -- us2k10--------
    rs1453804131,2
    --73199675(+) AAAAA-/GA    
       CAAAG
    AAAAA
    1 -- us2k10--------
    rs1862420051,2
    --73199699(+) GAGAGA/CGAGCT 1 -- us2k10--------
    rs573042951,2
    C--73199703(+) GAGAGC/ATTGTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs2010976601,2
    --73199703(+) GAGAG-/CTTGTTA 1 -- us2k10--------
    rs559110321,2
    C--73199704(+) AGAGCG/TTGTTA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs745335621,2
    C,F,--73199934(+) AATAGT/AGCTAT 1 -- us2k12Minor allele frequency- A:0.09WA NA 238
    rs1919473331,2
    --73199983(+) GTCGCC/TCAGGC 1 -- us2k10--------
    rs1822012331,2
    --73200035(+) CTCCCC/GGGTTC 1 -- us2k10--------
    rs99078361,2
    C,A--73200137(+) ttttgG/Tatttt 1 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for NUP85 (73201597 - 73231854 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NUP85
         1 Indel: 40204

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP85
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP85

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NUP85 for disorders           About GeneDecksing

    OMIM gene information: 170285    OMIM disorders: --

    1 disease for NUP85:    About MalaCards
    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: NUP85 (1 document)

    Export disorders for NUP85 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUP85 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with NUP85)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. (PubMed id 15995708)1, 2 Terashima Y.... Matsushima K. (2005)
    2. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. (PubMed id 15146057)1, 2 Loieodice I.... Doye V. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2 Cronshaw J.M.... Matunis M.J. (2002)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79902 HGNC: 8734 AceView: PCNT1 Ensembl:ENSG00000125450 euGenes: HUgn79902
    ECgene: NUP85 Kegg: 79902 H-InvDB: NUP85

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUP85 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUP85 gene:
    Search GeneIP for patents involving NUP85

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NUP85 (Nucleoporin NUP85)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NUP85   OriGene shRNA RFP for NUP85  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUP85   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NUP85  
     OriGene Protein Over-expression Lysate for NUP85   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NUP85   OriGene 3'-UTR Clone for NUP85  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NUP85   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NUP85  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUP85   OriGene Custom Protein Services for NUP85  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUP85
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUP85
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP85
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP85
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP85
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP85
     GenScript Custom Purified and Recombinant Proteins Services for NUP85 GenScript cDNA clones with any tag delivered in your preferred vector for NUP85
     GenScript Custom Assay Services for NUP85 GenScript Custom Superior Antibodies Services for NUP85
     GenScript Custom overexpressing Cell Line Services for NUP85 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NUP85 promoter
     Search Chromatin IP Primers for NUP85
     RT2 qPCR Primer Assay in human, mouse, rat NUP85
     Search GNC Networks for NUP85
     SABiosciences Custom PCR Arrays for NUP85
     Search Tocris compounds for NUP85
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NUP85 antibodies
     NUP85 proteins
     NUP85 lysates
     Search for Antibodies for NUP85 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NUP85
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NUP85 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NUP85
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP85
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NUP85
     SwitchGear Promoter luciferase reporter plasmids for NUP85
     ThermoFisher Antibodies for NUP85
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP85
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NUP85 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4