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Aliases for NUP85 Gene

Aliases for NUP85 Gene

  • Nucleoporin 85 2 3
  • Nucleoporin 85kDa 2 3 5
  • Nucleoporin Nup75 3 4
  • Nucleoporin Nup85 3 4
  • FROUNT 3 4
  • Nup75 3 4
  • 85 KDa Nucleoporin 4
  • Pericentrin-1 4
  • PCNT1 4

External Ids for NUP85 Gene

Previous GeneCards Identifiers for NUP85 Gene

  • GC17P070716
  • GC17P073201
  • GC17P068611

Summaries for NUP85 Gene

Entrez Gene Summary for NUP85 Gene

  • This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for NUP85 Gene

NUP85 (Nucleoporin 85) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR.

UniProtKB/Swiss-Prot for NUP85 Gene

  • Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade.

Gene Wiki entry for NUP85 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP85 Gene

Genomics for NUP85 Gene

Regulatory Elements for NUP85 Gene

Promoters for NUP85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUP85 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NUP85 gene promoter:

Genomic Location for NUP85 Gene

Chromosome:
17
Start:
75,205,450 bp from pter
End:
75,235,759 bp from pter
Size:
30,310 bases
Orientation:
Plus strand

Genomic View for NUP85 Gene

Genes around NUP85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP85 Gene

Proteins for NUP85 Gene

  • Protein details for NUP85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW27-NUP85_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup85
    Protein Accession:
    Q9BW27
    Secondary Accessions:
    • B4DMQ3
    • B4DPW1
    • Q8NDI4
    • Q9H9U1

    Protein attributes for NUP85 Gene

    Size:
    656 amino acids
    Molecular mass:
    75019 Da
    Quaternary structure:
    • Component of the nuclear pore complex (NPC). Component of the NPC Nup107-160 subcomplex, consisting of at least NUP107, NUP98/Nup96, NUP160, NUP133, NUP85, NUP37, NUP43 and SEC13. Interacts with NUP160, NUP133 and SEC13. Interacts with NUP37, NUP107 and NUP43. Interacts with CCR2.
    SequenceCaution:
    • Sequence=CAD38749.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP85 Gene

    Alternative splice isoforms for NUP85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP85 Gene

Proteomics data for NUP85 Gene at MOPED

Post-translational modifications for NUP85 Gene

  • Ubiquitination at Lys 59, Lys 70, Lys 92, Lys 124, Lys 449, Lys 494, Lys 540, and Lys 631
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for NUP85 (Nucleoporin NUP85)
  • Cloud-Clone Corp. Antibodies for NUP85

No data available for DME Specific Peptides for NUP85 Gene

Domains & Families for NUP85 Gene

Gene Families for NUP85 Gene

Protein Domains for NUP85 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BW27

UniProtKB/Swiss-Prot:

NUP85_HUMAN :
  • Belongs to the nucleoporin Nup85 family.
Family:
  • Belongs to the nucleoporin Nup85 family.
genes like me logo Genes that share domains with NUP85: view

Function for NUP85 Gene

Molecular function for NUP85 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade.
genes like me logo Genes that share phenotypes with NUP85: view

Animal Models for NUP85 Gene

MGI Knock Outs for NUP85:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUP85 Gene

Localization for NUP85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP85 Gene

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356). Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708). {ECO:0000269 PubMed:12718872, ECO:0000269 PubMed:15995708, ECO:0000269 PubMed:16807356}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP85 Gene COMPARTMENTS Subcellular localization image for NUP85 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 3
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NUP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with NUP85: view

Pathways & Interactions for NUP85 Gene

SuperPathways for NUP85 Gene

Superpath Contained pathways
1 Regulation of Glucokinase by Glucokinase Regulatory Protein
2 Infectious disease
.48
3 SUMOylation
4 Mitotic Prophase
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with NUP85: view

Pathways by source for NUP85 Gene

1 KEGG pathway for NUP85 Gene

Gene Ontology (GO) - Biological Process for NUP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006935 chemotaxis IEA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with NUP85: view

No data available for SIGNOR curated interactions for NUP85 Gene

Drugs & Compounds for NUP85 Gene

No Compound Related Data Available

Transcripts for NUP85 Gene

Unigene Clusters for NUP85 Gene

Nucleoporin 85kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP85 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
SP1: -
SP2: -
SP3: - - -
SP4:
SP5:
SP6:
SP7:

ExUns: 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for NUP85 Gene

GeneLoc Exon Structure for
NUP85
ECgene alternative splicing isoforms for
NUP85

Expression for NUP85 Gene

mRNA expression in normal human tissues for NUP85 Gene

Protein differential expression in normal tissues from HIPED for NUP85 Gene

This gene is overexpressed in Adrenal (9.2), Testis (8.4), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP85 Gene



SOURCE GeneReport for Unigene cluster for NUP85 Gene Hs.362817

genes like me logo Genes that share expression patterns with NUP85: view

Protein tissue co-expression partners for NUP85 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUP85 Gene

Orthologs for NUP85 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP85 36
  • 100 (a)
OneToOne
NUP85 35
  • 99.59 (n)
  • 99.7 (a)
cow
(Bos Taurus)
Mammalia NUP85 36
  • 90 (a)
OneToOne
NUP85 35
  • 88.36 (n)
  • 90.4 (a)
dog
(Canis familiaris)
Mammalia NUP85 35
  • 89.57 (n)
  • 91.76 (a)
NUP85 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup85 36
  • 92 (a)
OneToOne
Nup85 16
Nup85 35
  • 86.48 (n)
  • 91.62 (a)
oppossum
(Monodelphis domestica)
Mammalia NUP85 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP85 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup85 35
  • 86.69 (n)
  • 92.53 (a)
chicken
(Gallus gallus)
Aves NUP85 35
  • 72.2 (n)
  • 74.19 (a)
NUP85 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP85 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14618 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nup85 35
  • 68.1 (n)
  • 68.25 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10923 35
zebrafish
(Danio rerio)
Actinopterygii nup85 35
  • 66.98 (n)
  • 66.46 (a)
nup85 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012362 35
  • 45.82 (n)
  • 32.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup75 36
  • 30 (a)
OneToOne
Nup75 35
  • 45.92 (n)
  • 34.74 (a)
worm
(Caenorhabditis elegans)
Secernentea npp-2 36
  • 22 (a)
OneToOne
npp-2 35
  • 37.56 (n)
  • 23.94 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32910 35
  • 42.5 (n)
  • 31.27 (a)
rice
(Oryza sativa)
Liliopsida Os01g0746200 35
  • 40.38 (n)
  • 27.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for NUP85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP85 Gene

ENSEMBL:
Gene Tree for NUP85 (if available)
TreeFam:
Gene Tree for NUP85 (if available)

Paralogs for NUP85 Gene

No data available for Paralogs for NUP85 Gene

Variants for NUP85 Gene

Sequence variations from dbSNP and Humsavar for NUP85 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2078567 -- 75,222,107(+) ggtca(A/C/G/T)attac intron-variant
rs2291026 -- 75,205,382(-) TGCGT(A/G)GGCTG upstream-variant-2KB
rs3047550 -- 75,222,061(-) TCTCA(-/AAAC)AAACA intron-variant
rs3047551 -- 75,222,026(-) ACACA(-/CACA)CACGA intron-variant
rs4789150 -- 75,211,705(+) AAATA(C/T)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP85 Gene

Variant ID Type Subtype PubMed ID
nsv908756 CNV Loss 21882294
nsv470602 CNV Loss 18288195
nsv908758 CNV Loss 21882294
esv2716236 CNV Deletion 23290073

Variation tolerance for NUP85 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP85 Gene

HapMap Linkage Disequilibrium report
NUP85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP85 Gene

Disorders for NUP85 Gene

Relevant External Links for NUP85

Genetic Association Database (GAD)
NUP85
Human Genome Epidemiology (HuGE) Navigator
NUP85
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP85

No disorders were found for NUP85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP85 Gene

Publications for NUP85 Gene

  1. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. (PMID: 15995708) Terashima Y. … Matsushima K. (Nat. Immunol. 2005) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for NUP85 Gene

Sources for NUP85 Gene

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