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Aliases for NUP85 Gene

Aliases for NUP85 Gene

  • Nucleoporin 85 2 3 5
  • Nucleoporin 85kDa 2 3
  • Nucleoporin Nup75 3 4
  • Nucleoporin Nup85 3 4
  • FROUNT 3 4
  • Nup75 3 4
  • Nuclear Pore Complex Protein Nup85 3
  • 85 KDa Nucleoporin 4
  • Pericentrin-1 4
  • PCNT1 4

External Ids for NUP85 Gene

Previous GeneCards Identifiers for NUP85 Gene

  • GC17P070716
  • GC17P073201
  • GC17P068611

Summaries for NUP85 Gene

Entrez Gene Summary for NUP85 Gene

  • This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for NUP85 Gene

NUP85 (Nucleoporin 85) is a Protein Coding gene. Among its related pathways are Transport of the SLBP independent Mature mRNA and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NUP85 Gene

  • Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708).

Gene Wiki entry for NUP85 Gene

Additional gene information for NUP85 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP85 Gene

Genomics for NUP85 Gene

Regulatory Elements for NUP85 Gene

Enhancers for NUP85 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H074511 2.1 FANTOM5 Ensembl ENCODE dbSUPER 154.9 -691.8 -691847 3.3 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF302 ZNF416 ZNF207 NUP85 NAT9 NT5C GGA3 RN7SL573P HID1-AS1 CD300E CDR2L CD300A ENSG00000266765
GH17H075085 2 FANTOM5 Ensembl ENCODE dbSUPER 85.7 -114.0 -113955 11.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 NUP85 UNK NT5C ENSG00000266980 ENSG00000267342 NAT9 GGA3 TRIM65 RN7SL573P SAP30BP
GH17H075776 2.4 ENCODE dbSUPER 56.7 +573.1 573077 4.9 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 UNK NUP85 SRSF2 ENSG00000267342 NT5C ENSG00000266980 MFSD11 METTL23 TRIM65 GGA3
GH17H075031 1.8 FANTOM5 ENCODE dbSUPER 70.9 -170.8 -170830 5.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC NUP85 UNK ENSG00000266980 GGA3 NT5C TRIM65 ENSG00000267342 KCTD2 ATP5H RN7SL573P
GH17H074461 1.9 FANTOM5 Ensembl ENCODE dbSUPER 57.4 -739.7 -739681 9.3 HDGF PKNOX1 FOXA2 ZFP64 SIN3A YBX1 ZNF766 ZNF143 ZNF207 SP5 NAT9 NUP85 NT5C GGA3 CD300A MGC16275 GPR142 CD300LB ARMC7 BTBD17
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP85 on UCSC Golden Path with GeneCards custom track

Promoters for NUP85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098339 350 2401 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143

Transcription factor binding sites by QIAGEN in the NUP85 gene promoter:

Genomic Locations for NUP85 Gene

Genomic Locations for NUP85 Gene
chr17:75,205,450-75,235,759
(GRCh38/hg38)
Size:
30,310 bases
Orientation:
Plus strand
chr17:73,201,597-73,231,854
(GRCh37/hg19)

Genomic View for NUP85 Gene

Genes around NUP85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP85 Gene

Proteins for NUP85 Gene

  • Protein details for NUP85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW27-NUP85_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup85
    Protein Accession:
    Q9BW27
    Secondary Accessions:
    • B4DMQ3
    • B4DPW1
    • Q8NDI4
    • Q9H9U1

    Protein attributes for NUP85 Gene

    Size:
    656 amino acids
    Molecular mass:
    75019 Da
    Quaternary structure:
    • Component of the nuclear pore complex (NPC) (PubMed:12196509). Component of the NPC Nup107-160 subcomplex, consisting of at least NUP107, NUP98/Nup96, NUP160, NUP133, NUP85, NUP37, NUP43 and SEC13 (PubMed:15146057). Interacts with NUP160, NUP133 and SEC13 (PubMed:12718872). Interacts with NUP37, NUP107 and NUP43 (PubMed:15146057). Interacts with CCR2 (PubMed:15995708).
    SequenceCaution:
    • Sequence=CAD38749.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP85 Gene

    Alternative splice isoforms for NUP85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP85 Gene

Post-translational modifications for NUP85 Gene

  • Ubiquitination at Lys59, posLast=7070, posLast=9292, posLast=124124, posLast=449449, Lys494, posLast=540540, and Lys631
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUP85 Gene

Domains & Families for NUP85 Gene

Gene Families for NUP85 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for NUP85 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BW27

UniProtKB/Swiss-Prot:

NUP85_HUMAN :
  • Belongs to the nucleoporin Nup85 family.
Family:
  • Belongs to the nucleoporin Nup85 family.
genes like me logo Genes that share domains with NUP85: view

Function for NUP85 Gene

Molecular function for NUP85 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708).

Phenotypes From GWAS Catalog for NUP85 Gene

Gene Ontology (GO) - Molecular Function for NUP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15146057
GO:0017056 structural constituent of nuclear pore IBA --
genes like me logo Genes that share ontologies with NUP85: view
genes like me logo Genes that share phenotypes with NUP85: view

Animal Models for NUP85 Gene

MGI Knock Outs for NUP85:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUP85 Gene

Localization for NUP85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP85 Gene

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356). Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708). {ECO:0000269 PubMed:12718872, ECO:0000269 PubMed:15995708, ECO:0000269 PubMed:16807356}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP85 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NUP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 colocalizes_with kinetochore IEA,IDA 15146057
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IEA --
genes like me logo Genes that share ontologies with NUP85: view

Pathways & Interactions for NUP85 Gene

SuperPathways for NUP85 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with NUP85: view

Pathways by source for NUP85 Gene

Gene Ontology (GO) - Biological Process for NUP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006110 regulation of glycolytic process TAS --
GO:0006406 mRNA export from nucleus TAS,IBA --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with NUP85: view

No data available for SIGNOR curated interactions for NUP85 Gene

Drugs & Compounds for NUP85 Gene

No Compound Related Data Available

Transcripts for NUP85 Gene

Unigene Clusters for NUP85 Gene

Nucleoporin 85kDa:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP85 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
SP1: -
SP2: -
SP3: - - -
SP4:
SP5:
SP6:
SP7:

ExUns: 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for NUP85 Gene

GeneLoc Exon Structure for
NUP85
ECgene alternative splicing isoforms for
NUP85

Expression for NUP85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP85 Gene

Protein differential expression in normal tissues from HIPED for NUP85 Gene

This gene is overexpressed in Adrenal (9.2), Testis (8.4), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUP85 Gene



Protein tissue co-expression partners for NUP85 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUP85 Gene:

NUP85

SOURCE GeneReport for Unigene cluster for NUP85 Gene:

Hs.362817

Evidence on tissue expression from TISSUES for NUP85 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NUP85: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP85 Gene

Orthologs for NUP85 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUP85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP85 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia NUP85 33 34
  • 89.57 (n)
cow
(Bos Taurus)
Mammalia NUP85 33 34
  • 88.36 (n)
oppossum
(Monodelphis domestica)
Mammalia NUP85 34
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup85 33
  • 86.69 (n)
mouse
(Mus musculus)
Mammalia Nup85 33 16 34
  • 86.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NUP85 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUP85 33 34
  • 72.2 (n)
lizard
(Anolis carolinensis)
Reptilia NUP85 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nup85 33
  • 68.1 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14618 33
zebrafish
(Danio rerio)
Actinopterygii nup85 33 34
  • 66.98 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10923 33
fruit fly
(Drosophila melanogaster)
Insecta Nup75 33 34
  • 45.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012362 33
  • 45.82 (n)
worm
(Caenorhabditis elegans)
Secernentea npp-2 33 34
  • 37.56 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32910 33
  • 42.5 (n)
rice
(Oryza sativa)
Liliopsida Os01g0746200 33
  • 40.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for NUP85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUP85 Gene

ENSEMBL:
Gene Tree for NUP85 (if available)
TreeFam:
Gene Tree for NUP85 (if available)

Paralogs for NUP85 Gene

No data available for Paralogs for NUP85 Gene

Variants for NUP85 Gene

Sequence variations from dbSNP and Humsavar for NUP85 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000286168 -- 75,220,091(+) GGTTA(C/G)CATTC intron-variant
rs1000298172 -- 75,206,856(+) CCACG(C/T)CCGGC intron-variant
rs1000403465 -- 75,235,301(+) TATGG(A/G)CACAT intron-variant
rs1000768457 -- 75,230,569(+) TTAGC(A/G)AAGAT intron-variant
rs1000863247 -- 75,230,919(+) CACCT(C/T)AACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP85 Gene

Variant ID Type Subtype PubMed ID
nsv960528 CNV duplication 23825009
nsv470602 CNV loss 18288195
esv2716236 CNV deletion 23290073

Variation tolerance for NUP85 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP85 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP85 Gene

Disorders for NUP85 Gene

Relevant External Links for NUP85

Genetic Association Database (GAD)
NUP85
Human Genome Epidemiology (HuGE) Navigator
NUP85
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP85

No disorders were found for NUP85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP85 Gene

Publications for NUP85 Gene

  1. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. (PMID: 15995708) Terashima Y … Matsushima K (Nature immunology 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. (PMID: 15146057) Loïodice I … Doye V (Molecular biology of the cell 2004) 3 4 60
  4. Proteomic analysis of the mammalian nuclear pore complex. (PMID: 12196509) Cronshaw JM … Matunis MJ (The Journal of cell biology 2002) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for NUP85 Gene

Sources for NUP85 Gene