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NUP85 Gene

protein-coding   GIFtS: 57
GCID: GC17P073201

Nucleoporin 85kDa

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleoporin 85kDa1 2     Nuclear Pore Complex Protein Nup852
Nucleoporin Nup752 3     pericentrin-12
Nucleoporin Nup852 3     FROUNT3
85 KDa Nucleoporin2 3     NUP753
PCNT13 5     Pericentrin-13
Nup752     PCNT5
frount2     

External Ids:    HGNC: 87341   Entrez Gene: 799022   Ensembl: ENSG000001254507   OMIM: 1702855   UniProtKB: Q9BW273   

Export aliases for NUP85 gene to outside databases

Previous GC identifers: GC17P070716 GC17P068611


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUP85 Gene:
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes
(NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such
subcomplex, Nup107-160. (provided by RefSeq, Jul 2008)

GeneCards Summary for NUP85 Gene:
NUP85 (nucleoporin 85kDa) is a protein-coding gene. Diseases associated with NUP85 include influenza, and hiv-1.

UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27
Function: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and
maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and
NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is
required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of
monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade

Gene Wiki entry for NUP85 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUP85 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP85 promoter sequence
   Search Chromatin IP Primers for NUP85

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUP85


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

NUP85 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP85 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073201:  view genomic region     (about GC identifiers)

Start:
73,201,597 bp from pter      End:
73,231,854 bp from pter
Size:
30,258 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup85  
Size: 656 amino acids; 75019 Da
Subunit: Component of the nuclear pore complex (NPC). Component of the NPC Nup107-160 subcomplex, consisting of at
least NUP107, NUP98/Nup96, NUP160, NUP133, NUP85, NUP37, NUP43 and SEC13. Interacts with NUP160, NUP133 and
SEC13. Interacts with NUP37, NUP107 and NUP43. Interacts with CCR2
Sequence caution: Sequence=CAD38749.1; Type=Erroneous initiation;
Secondary accessions: Q8NDI4 Q9H9U1

Explore the universe of human proteins at neXtProt for NUP85: NX_Q9BW27

Explore proteomics data for NUP85 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59, Lys70, Lys92, Lys124, Lys449, Lys494, Lys540, Lys631
  • Modification sites at PhosphoSitePlus

  • See NUP85 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079120.1  
    ENSEMBL proteins: 
     ENSP00000462487   ENSP00000245544   ENSP00000463382   ENSP00000462749   ENSP00000461919  
     ENSP00000462920   ENSP00000463715   ENSP00000463496   ENSP00000463542   ENSP00000463377  
     ENSP00000445855   ENSP00000463437   ENSP00000464544   ENSP00000462364   ENSP00000464433  
     ENSP00000441762   ENSP00000408261  
    Reactome Protein details: Q9BW27

    NUP85 Human Recombinant Protein Products:

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    Novus Biologicals NUP85 Protein
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    Cloud-Clone Corp. Proteins for NUP85

    NUP85 Antibody Products:

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    NUP85 Assay Products:

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    Cloud-Clone Corp. CLIAs for NUP85


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR011502 Nucleoporin_Nup85

    Graphical View of Domain Structure for InterPro Entry Q9BW27

    ProtoNet protein and cluster: Q9BW27

    UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27
    Similarity: Belongs to the nucleoporin Nup85 family


    NUP85 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUP85_HUMAN, Q9BW27
    Function: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and
    maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and
    NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is
    required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of
    monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15146057
         
    NUP85 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NUP85:
     Decreased p24 protein expressi  Increased gamma-H2AX phosphory  Nuclear pre-40S maturation def 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nup85):
     mortality/aging 

    NUP85 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUP85
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP85
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUP85

    miRNA
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    miRTarBase miRNAs that target NUP85:
    hsa-mir-324-5p (MIRT043204)

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    GenScript: all cDNA clones in your preferred vector: NUP85 (NM_024844)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP85
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP85

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUP85_HUMAN, Q9BW27: Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton,
    spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon
    CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of
    migrating cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776colocalizes with kinetochore IDA15146057
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005635nuclear envelope TAS--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--

    NUP85 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUP85 About   (see all 17)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NUP85
        Integrated Breast Cancer Pathway

    Selected Reactome Pathways for NUP85 (see all 9)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear Pore Complex (NPC) Disassembly
    Nuclear import of Rev protein
    Resolution of Sister Chromatid Cohesion


    1 Kegg Pathway  (Kegg details for NUP85):
        RNA transport


    NUP85 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUP85
    Interactions:

        Search GeneGlobe Interaction Network for NUP85

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NUP85 (Q9BW272, 3 ENSP000002455444) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266412, 3MINT-65375 I2D: score=5 
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    DYNC1LI1Q9Y6G93, ENSP000002731304I2D: score=1 STRING: ENSP00000273130
    NUP107P577403, ENSP000002291794I2D: score=1 STRING: ENSP00000229179
    NUP43Q8NFH33, ENSP000003422624I2D: score=1 STRING: ENSP00000342262
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006935chemotaxis ----
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    NUP85 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUP85



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUP85 gene: 
    NM_024844.3  

    Unigene Cluster for NUP85:

    Nucleoporin 85kDa
    Hs.362817  [show with all ESTs]
    Unigene Representative Sequence: NM_024844
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000583569 ENST00000583948 ENST00000245544(uc002jng.1 uc010wrv.1)
    ENST00000582833 ENST00000579324 ENST00000449421 ENST00000577208 ENST00000583548
    ENST00000579298 ENST00000581104 ENST00000578830 ENST00000583877 ENST00000577561
    ENST00000579557 ENST00000577645 ENST00000583070 ENST00000580879 ENST00000581335

    miRNA
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    GenScript: all cDNA clones in your preferred vector: NUP85 (NM_024844)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP85
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      QuantiTect SYBR Green Assays in human, mouse, rat NUP85
      QuantiFast Probe-based Assays in human, mouse, rat NUP85

    Additional mRNA sequence: 

    AF498261.1 AF514995.1 AK022611.1 AK124501.1 AK295694.1 AK297574.1 AK298519.1 AK302426.1 
    AL833893.1 BC000697.2 

    19 DOTS entries:

    DT.444220  DT.100816167  DT.95353340  DT.100816177  DT.95353339  DT.40108066  DT.95353342  DT.100816170 
    DT.120979202  DT.120979186  DT.97854685  DT.100753625  DT.120979179  DT.75130986  DT.91676126  DT.91764338 
    DT.95353341  DT.99929007  DT.99968516 

    Selected AceView cDNA sequences (see all 354):

    BF195124 BQ218862 CD723328 BM823992 BI917183 BE294950 AA776958 BQ651621 
    BU196881 BM563114 AL515687 AI096409 CA454051 BM825777 BI906138 BM833386 
    AA400664 AI271569 BQ649864 BM927831 BQ063852 BX462224 BI757463 AA425086 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUP85 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
    SP1:                                                                                                        -                                                   
    SP2:              -                                                                                                                                             
    SP3:                                                                                      -           -     -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for NUP85

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUP85 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAATCTGA
    NUP85 Expression
    About this image

    NUP85 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUP85 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.362817
        Custom PCR Arrays for NUP85
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NUP85
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP85

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUP85 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup851 , 5 nucleoporin 851, 5 86.48(n)1
    91.62(a)1
      11 (80.87 cM)5
    4450071  NM_001002929.41  NP_001002929.31 
     1155644345 
    chicken
    (Gallus gallus)
    Aves NUP851 nucleoporin 85kDa 72.2(n)
    74.19(a)
      422120  NM_001006426.1  NP_001006426.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUP856
    nucleoporin 85kDa
    76(a)
    1 ↔ 1
    2(114703818-114729270)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146182 Xenopus laevis transcribed sequence with moderate similarity more 74.51(n)    BJ062967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570616392   -- 72.72(n)    57061639 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nup751 Nucleoporin 75 45.92(n)
    34.74(a)
      37078  NM_137456.3  NP_611300.2 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-21 npp-2 37.56(n)
    23.94(a)
      172611  NM_059855.4  NP_492256.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G329101 AT4G32910 42.5(n)
    31.27(a)
      829427  NM_119444.3  NP_567908.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07462001 Os01g0746200 40.38(n)
    27.03(a)
      4326176  NM_001050763.1  NP_001044228.1 


    ENSEMBL Gene Tree for NUP85 (if available)
    TreeFam Gene Tree for NUP85 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NUP85 (see all 886)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815398301,2
    --73199611(+) CTCCAC/TTCCAG 1 -- us2k10--------
    rs1453804131,2
    --73199675(+) AAAAA-/GA    
       CAAAG
    AAAAA
    1 -- us2k10--------
    rs1862420051,2
    --73199699(+) GAGAGA/CGAGCT 1 -- us2k10--------
    rs573042951,2
    C--73199703(+) GAGAGC/ATTGTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs2010976601,2
    --73199703(+) GAGAG-/CTTGTTA 1 -- us2k10--------
    rs559110321,2
    C--73199704(+) AGAGCG/TTGTTA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs745335621,2
    C,F--73199934(+) AATAGT/AGCTAT 1 -- us2k12Minor allele frequency- A:0.09WA NA 238
    rs1919473331,2
    --73199983(+) GTCGCC/TCAGGC 1 -- us2k10--------
    rs1822012331,2
    --73200035(+) CTCCCC/GGGTTC 1 -- us2k10--------
    rs99078361,2
    C,A--73200137(+) ttttgG/Tatttt 1 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for NUP85 (73201597 - 73231854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUP85:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716236CNV Deletion23290073
    nsv908756CNV Loss21882294
    nsv908758CNV Loss21882294
    nsv470602CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUP85
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP85

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 170285    OMIM disorders: --

    5 diseases for NUP85:    
    About MalaCards
    influenza    hiv-1    breast cancer    malaria
    hepatitis


    NUP85 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUP85
    Human Genome Epidemiology (HuGE) Navigator: NUP85 (1 document)

    Export disorders for NUP85 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUP85 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with NUP85)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. (PubMed id 15995708)1, 2 Terashima Y.... Matsushima K. (Nat. Immunol. 2005)
    2. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. (PubMed id 15146057)1, 2 Loieodice I.... Doye V. (Mol. Biol. Cell 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2 Cronshaw J.M.... Matunis M.J. (J. Cell Biol. 2002)
    5. Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5. (PubMed id 24128342)1 Toda E....Matsushima K. (Biochem. J. 2014)
    6. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    7. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79902 HGNC: 8734 AceView: PCNT1 Ensembl:ENSG00000125450 euGenes: HUgn79902
    ECgene: NUP85 Kegg: 79902 H-InvDB: NUP85

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUP85 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUP85 gene:
    Search GeneIP for patents involving NUP85

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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