Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUP85 Gene

protein-coding   GIFtS: 57
GCID: GC17P073201

Nucleoporin 85kDa

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleoporin 85kDa1 2     Nuclear Pore Complex Protein Nup852
Nucleoporin Nup752 3     pericentrin-12
Nucleoporin Nup852 3     FROUNT3
85 KDa Nucleoporin2 3     NUP753
PCNT13 5     Pericentrin-13
Nup752     PCNT5
frount2     

External Ids:    HGNC: 87341   Entrez Gene: 799022   Ensembl: ENSG000001254507   OMIM: 1702855   UniProtKB: Q9BW273   

Export aliases for NUP85 gene to outside databases

Previous GC identifers: GC17P070716 GC17P068611


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUP85 Gene:
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes
(NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such
subcomplex, Nup107-160. (provided by RefSeq, Jul 2008)

GeneCards Summary for NUP85 Gene: 
NUP85 (nucleoporin 85kDa) is a protein-coding gene. Diseases associated with NUP85 include influenza, and hepatitis, and among its related super-pathways are Interactions of Rev with host cellular proteins and Mitotic Anaphase. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27
Function: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and
maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and
NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is
required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of
monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade

Gene Wiki entry for NUP85 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUP85 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUP85 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUP85

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP85


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

NUP85 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUP85 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073201:  view genomic region     (about GC identifiers)

Start:
73,201,597 bp from pter      End:
73,231,854 bp from pter
Size:
30,258 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27 (See protein sequence)
Recommended Name: Nuclear pore complex protein Nup85  
Size: 656 amino acids; 75019 Da
Subunit: Component of the nuclear pore complex (NPC). Component of the NPC Nup107-160 subcomplex, consisting of at
least NUP107, NUP98/Nup96, NUP160, NUP133, NUP85, NUP37, NUP43 and SEC13. Interacts with NUP160, NUP133 and
SEC13. Interacts with NUP37, NUP107 and NUP43. Interacts with CCR2
Subcellular location: Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton,
spindle. Cytoplasm. Nucleus membrane. Note=During mitosis, localizes to the kinetochores and spindle poles. Upon
CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of
migrating cells
Sequence caution: Sequence=CAD38749.1; Type=Erroneous initiation;
Secondary accessions: Q8NDI4 Q9H9U1

Explore the universe of human proteins at neXtProt for NUP85: NX_Q9BW27

Explore proteomics data for NUP85 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BW27

  • NUP85 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUP85 Protein Expression
    REFSEQ proteins: NP_079120.1  
    ENSEMBL proteins: 
     ENSP00000462487   ENSP00000245544   ENSP00000463382   ENSP00000462749   ENSP00000461919  
     ENSP00000462920   ENSP00000463715   ENSP00000463496   ENSP00000463542   ENSP00000463377  
     ENSP00000445855   ENSP00000463437   ENSP00000464544   ENSP00000462364   ENSP00000464433  
     ENSP00000441762   ENSP00000408261  
    Reactome Protein details: Q9BW27
    Human Recombinant Protein Products for NUP85: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NUP85
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NUP85
    GenScript Custom Purified and Recombinant Proteins Services for NUP85
    Novus Biologicals NUP85 Protein
    Novus Biologicals NUP85 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUP85 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776colocalizes with kinetochore IDA15146057
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005635nuclear envelope TAS--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--

    NUP85 for ontologies           About GeneDecksing



    NUP85 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NUP85 (Nucleoporin NUP85)
    OriGene Antibodies for NUP85
    OriGene Custom Antibody Services for NUP85
    GenScript Custom Superior Antibodies Services for NUP85
    Novus Biologicals NUP85 Antibodies
    Abcam antibodies for NUP85
    Cloud-Clone Corp. Antibodies for NUP85 
    ThermoFisher Antibodies for NUP85
    LSBio Antibodies in human, mouse, rat for NUP85 

    Assay Products for NUP85: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NUP85
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUP85
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NUP85 
    Cloud-Clone Corp. CLIAs for NUP85


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR011502 Nucleoporin_Nup85

    Graphical View of Domain Structure for InterPro Entry Q9BW27

    ProtoNet protein and cluster: Q9BW27

    UniProtKB/Swiss-Prot: NUP85_HUMAN, Q9BW27
    Similarity: Belongs to the nucleoporin Nup85 family


    NUP85 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUP85_HUMAN, Q9BW27
    Function: Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and
    maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and
    NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is
    required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of
    monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15146057
         
    NUP85 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NUP85:
     Decreased p24 protein expressi  Increased gamma-H2AX phosphory  Nuclear pre-40S maturation def 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NUP85 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUP85

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUP85 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUP85 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP85
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NUP85
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUP85
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP85

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NUP85
    Sirion Biotech Customized adenovirus for overexpression of NUP85

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NUP85 (see all 7)
    OriGene ORF clones in mouse, rat for NUP85
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP85 (NM_024844)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP85
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP85
    Sirion Biotech Customized lentivirus for stable overexpression of NUP85 
                         Customized lentivirus expression plasmids for stable overexpression of NUP85 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NUP85
    Search LifeMap BioReagents cell lines for NUP85
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP85


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUP85 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.94
    Hexose transport0.87
    Nuclear import of Rev protein0.94
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.82
    Interactions of Rev with host cellular proteins0.94
    Nuclear Pore Complex (NPC) Disassembly0.77
    Vpr-mediated nuclear import of PICs0.91
    Nuclear Envelope Breakdown0.77
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    4Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    5Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NUP85
        Integrated Breast Cancer Pathway

    5/34        Reactome Pathways for NUP85 (see all 34)
        Mitotic Prometaphase
    Interactions of Rev with host cellular proteins
    Rev-mediated nuclear export of HIV RNA
    Mitotic Prophase
    Interferon Signaling


    1         Kegg Pathway  (Kegg details for NUP85):
        RNA transport


    NUP85 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUP85

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/139 Interacting proteins for NUP85 (Q9BW272, 3 ENSP000002455444) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266412, 3MINT-65375 I2D: score=5 
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    DYNC1LI1Q9Y6G93, ENSP000002731304I2D: score=1 STRING: ENSP00000273130
    NUP107P577403, ENSP000002291794I2D: score=1 STRING: ENSP00000229179
    NUP43Q8NFH33, ENSP000003422624I2D: score=1 STRING: ENSP00000342262
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006935chemotaxis ----
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    NUP85 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUP85

    Search CenterWatch for drugs/clinical trials and news about NUP85

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUP85 gene: 
    NM_024844.3  

    Unigene Cluster for NUP85:

    Nucleoporin 85kDa
    Hs.362817  [show with all ESTs]
    Unigene Representative Sequence: NM_024844
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000583569 ENST00000583948 ENST00000245544(uc002jng.1 uc010wrv.1)
    ENST00000582833 ENST00000579324 ENST00000449421 ENST00000577208 ENST00000583548
    ENST00000579298 ENST00000581104 ENST00000578830 ENST00000583877 ENST00000577561
    ENST00000579557 ENST00000577645 ENST00000583070 ENST00000580879 ENST00000581335

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUP85
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NUP85
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NUP85
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP85
    Clone
    Products:
         
    OriGene clones in human, mouse for NUP85 (see all 7)
    OriGene ORF clones in mouse, rat for NUP85
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUP85 (NM_024844)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUP85
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP85
    Sirion Biotech Customized lentivirus for stable overexpression of NUP85 
                         Customized lentivirus expression plasmids for stable overexpression of NUP85 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NUP85
    OriGene qSTAR qPCR primer pairs in human, mouse for NUP85
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUP85
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP85
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP85

    Additional mRNA sequence: 

    AF498261.1 AF514995.1 AK022611.1 AK124501.1 AK295694.1 AK297574.1 AK298519.1 AK302426.1 
    AL833893.1 BC000697.2 

    19 DOTS entries:

    DT.444220  DT.100816167  DT.95353340  DT.100816177  DT.95353339  DT.40108066  DT.95353342  DT.100816170 
    DT.120979202  DT.120979186  DT.97854685  DT.100753625  DT.120979179  DT.75130986  DT.91676126  DT.91764338 
    DT.95353341  DT.99929007  DT.99968516 

    24/354 AceView cDNA sequences (see all 354):

    CA487311 BQ218862 BQ921886 BM924988 AA425086 BF195124 BI917183 CB161022 
    BI906138 CR614721 AI271569 AW192282 CF995675 AL515687 BQ649864 AI096409 
    BM563114 BF971032 AA315316 BI757463 BM833386 CA454051 AA776958 BU508100 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUP85 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^
    SP1:                                                                                                        -                                                   
    SP2:              -                                                                                                                                             
    SP3:                                                                                      -           -     -                                                   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for NUP85

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUP85 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAATCTGA
    NUP85 Expression
    About this image


    See NUP85 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUP85

    SOURCE GeneReport for Unigene cluster: Hs.362817
        SABiosciences Custom PCR Arrays for NUP85
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NUP85
    OriGene qSTAR qPCR primer pairs in human, mouse for NUP85
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NUP85
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP85
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP85
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP85

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUP85 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nup851 , 5 nucleoporin 851, 5 86.48(n)1
    91.62(a)1
      11 (80.87 cM)5
    4450071  NM_001002929.41  NP_001002929.31 
     1155644345 
    chicken
    (Gallus gallus)
    Aves NUP851 nucleoporin 85kDa 72.09(n)
    74.19(a)
      422120  NM_001006426.1  NP_001006426.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUP856
    Uncharacterized protein
    75(a)
    1 ↔ 1
    2(114703818-114729270)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146182 Xenopus laevis transcribed sequence with moderate similarity more 74.51(n)    BJ062967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570616392   -- 72.72(n)    57061639 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nup751 Nucleoporin 75 45.11(n)
    33.84(a)
      37078  NM_137456.2  NP_611300.2 
    worm
    (Caenorhabditis elegans)
    Secernentea npp-21 Protein NPP-2 37.4(n)
    24.18(a)
      172611  NM_059855.3  NP_492256.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G329101 hypothetical protein 40.81(n)
    27.88(a)
      829427  NM_119444.3  NP_567908.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g07462001 hypothetical protein 40.53(n)
    28.31(a)
      4326176  NM_001050763.1  NP_001044228.1 


    ENSEMBL Gene Tree for NUP85 (if available)
    TreeFam Gene Tree for NUP85 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/886 SNPs in NUP85 are shown (see all 886)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815398301,2
    --73199611(+) CTCCAC/TTCCAG 1 -- us2k10--------
    rs1453804131,2
    --73199675(+) AAAAA-/GA    
       CAAAG
    AAAAA
    1 -- us2k10--------
    rs1862420051,2
    --73199699(+) GAGAGA/CGAGCT 1 -- us2k10--------
    rs573042951,2
    C--73199703(+) GAGAGC/ATTGTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs2010976601,2
    --73199703(+) GAGAG-/CTTGTTA 1 -- us2k10--------
    rs559110321,2
    C--73199704(+) AGAGCG/TTGTTA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs745335621,2
    C,F--73199934(+) AATAGT/AGCTAT 1 -- us2k12Minor allele frequency- A:0.09WA NA 238
    rs1919473331,2
    --73199983(+) GTCGCC/TCAGGC 1 -- us2k10--------
    rs1822012331,2
    --73200035(+) CTCCCC/GGGTTC 1 -- us2k10--------
    rs99078361,2
    C,A--73200137(+) ttttgG/Tatttt 1 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for NUP85 (73201597 - 73231854 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NUP85:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716236CNV Deletion23290073
    nsv908756CNV Loss21882294
    nsv908758CNV Loss21882294
    nsv470602CNV Loss18288195

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NUP85
    DNA2.0 Custom Variant and Variant Library Synthesis for NUP85

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 170285    OMIM disorders: --

    3 diseases for NUP85:    About MalaCards
    influenza    hepatitis    breast cancer


    NUP85 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUP85
    Human Genome Epidemiology (HuGE) Navigator: NUP85 (1 document)

    Export disorders for NUP85 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUP85 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with NUP85)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. (PubMed id 15995708)1, 2 Terashima Y.... Matsushima K. (2005)
    2. The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. (PubMed id 15146057)1, 2 Loieodice I.... Doye V. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2 Cronshaw J.M.... Matunis M.J. (2002)
    5. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79902 HGNC: 8734 AceView: PCNT1 Ensembl:ENSG00000125450 euGenes: HUgn79902
    ECgene: NUP85 Kegg: 79902 H-InvDB: NUP85

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUP85 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUP85 gene:
    Search GeneIP for patents involving NUP85

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for NUP85 (Nucleoporin NUP85)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NUP85   OriGene RNAi products in human, mouse, rat for NUP85  
     OriGene qPCR primer pairs and template standards for NUP85   OriGene Protein Over-expression Lysate for NUP85  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NUP85  
     OriGene qSTAR qPCR primer pairs in human, mouse for NUP85   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NUP85   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUP85   OriGene Custom Protein Services for NUP85  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NUP85
     QIAGEN SeqTarget long-range PCR primers for resequencing NUP85
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUP85
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUP85
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUP85
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUP85
     GenScript Custom Purified and Recombinant Proteins Services for NUP85 GenScript cDNA clones with any tag delivered in your preferred vector for NUP85
     GenScript Custom Assay Services for NUP85 GenScript Custom Superior Antibodies Services for NUP85
     GenScript Custom overexpressing Cell Line Services for NUP85 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NUP85 promoter
     Search Chromatin IP Primers for NUP85
     RT2 qPCR Primer Assay in human, mouse, rat NUP85
     Search GNC Networks for NUP85
     SABiosciences Custom PCR Arrays for NUP85
     Search Tocris compounds for NUP85
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NUP85 antibodies
     NUP85 proteins
     NUP85 lysates
     Antibodies for NUP85
     See all of Abcam's Antibodies, Kits and Proteins for NUP85
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NUP85
     Antibodies for NUP85
     ELISAs for NUP85
     CLIAs for NUP85
     Search LifeMap BioReagents cell lines for NUP85
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUP85
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NUP85
     SwitchGear Promoter luciferase reporter plasmids for NUP85
     ThermoFisher Antibodies for NUP85
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUP85
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NUP85
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NUP85
    Customized:
     lentivirus for stable overexpression of NUP85
     lentivirus expression plasmids for stable overexpression of NUP85
     adenovirus for overexpression of NUP85
     LSBio Antibodies in human, mouse, rat for NUP85
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NUP85 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4