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Aliases for NUP62CL Gene

Aliases for NUP62CL Gene

  • Nucleoporin 62 C-Terminal Like 2 3 5
  • Nucleoporin 62kDa C-Terminal Like 2
  • NUP62L 4

External Ids for NUP62CL Gene

Previous GeneCards Identifiers for NUP62CL Gene

  • GC0XM106253
  • GC0XM106366
  • GC0XM095994

Summaries for NUP62CL Gene

Entrez Gene Summary for NUP62CL Gene

  • This gene encodes a protein containing a domain found in nucleoporins which are glycoproteins found in nuclear pore complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for NUP62CL Gene

NUP62CL (Nucleoporin 62 C-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include structural constituent of nuclear pore. An important paralog of this gene is NUP62.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP62CL Gene

Genomics for NUP62CL Gene

Regulatory Elements for NUP62CL Gene

Enhancers for NUP62CL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG107134 1.1 Ensembl ENCODE 12.6 +70.0 70022 3.4 TBP NFRKB ZBTB40 GTF3C2 EGR1 FOS JUNB CEBPB ZNF592 MAFF NUP62CL PIH1D3 FRMPD3 MYCLP1 LOC644563 GC0XM107132
GH0XG107205 1 ENCODE 0.7 +0.4 379 1.9 PKNOX1 ATF1 ARID4B SIN3A TCF12 FOS KLF13 SP3 NFYC REST MYCLP1 ENSG00000199832 NUP62CL
GH0XG107204 0.7 ENCODE 0.7 +2.0 2008 0.4 HDAC1 ELF4 ELF1 DPF2 ZEB2 ZNF507 SMARCA4 IKZF1 SMC3 NBN ENSG00000199832 NUP62CL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUP62CL on UCSC Golden Path with GeneCards custom track

Promoters for NUP62CL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247833 339 1399 PKNOX1 ATF1 ARID4B SIN3A TCF12 FOS KLF13 SP3 NFYC REST

Genomic Location for NUP62CL Gene

Chromosome:
X
Start:
107,119,537 bp from pter
End:
107,206,440 bp from pter
Size:
86,904 bases
Orientation:
Minus strand

Genomic View for NUP62CL Gene

Genes around NUP62CL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUP62CL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUP62CL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP62CL Gene

Proteins for NUP62CL Gene

  • Protein details for NUP62CL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1M0-N62CL_HUMAN
    Recommended name:
    Nucleoporin-62 C-terminal-like protein
    Protein Accession:
    Q9H1M0
    Secondary Accessions:
    • D3DUX4
    • Q8WVL6
    • Q9NXP2

    Protein attributes for NUP62CL Gene

    Size:
    184 amino acids
    Molecular mass:
    20837 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NUP62CL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUP62CL Gene

Post-translational modifications for NUP62CL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUP62CL Gene

No data available for DME Specific Peptides for NUP62CL Gene

Domains & Families for NUP62CL Gene

Protein Domains for NUP62CL Gene

Suggested Antigen Peptide Sequences for NUP62CL Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1M0

UniProtKB/Swiss-Prot:

N62CL_HUMAN :
  • Belongs to the nucleoporin NSP1/NUP62 family.
Family:
  • Belongs to the nucleoporin NSP1/NUP62 family.
genes like me logo Genes that share domains with NUP62CL: view

No data available for Gene Families for NUP62CL Gene

Function for NUP62CL Gene

Gene Ontology (GO) - Molecular Function for NUP62CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0005543 phospholipid binding IBA --
GO:0017056 structural constituent of nuclear pore IEA,IBA --
genes like me logo Genes that share ontologies with NUP62CL: view

Phenotypes for NUP62CL Gene

GenomeRNAi human phenotypes for NUP62CL:
genes like me logo Genes that share phenotypes with NUP62CL: view

Animal Model Products

CRISPR Products

miRNA for NUP62CL Gene

miRTarBase miRNAs that target NUP62CL

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUP62CL Gene

Localization for NUP62CL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUP62CL gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUP62CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IEA --
GO:0044613 nuclear pore central transport channel IBA --
genes like me logo Genes that share ontologies with NUP62CL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUP62CL Gene

Pathways & Interactions for NUP62CL Gene

SuperPathways for NUP62CL Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUP62CL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006405 RNA export from nucleus IBA --
GO:0006606 protein import into nucleus IBA --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0071426 ribonucleoprotein complex export from nucleus IBA --
genes like me logo Genes that share ontologies with NUP62CL: view

No data available for Pathways by source and SIGNOR curated interactions for NUP62CL Gene

Drugs & Compounds for NUP62CL Gene

No Compound Related Data Available

Transcripts for NUP62CL Gene

mRNA/cDNA for NUP62CL Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUP62CL Gene

Nucleoporin 62kDa C-terminal like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUP62CL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: - -

Relevant External Links for NUP62CL Gene

GeneLoc Exon Structure for
NUP62CL
ECgene alternative splicing isoforms for
NUP62CL

Expression for NUP62CL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUP62CL Gene

mRNA differential expression in normal tissues according to GTEx for NUP62CL Gene

This gene is overexpressed in Testis (x7.8) and Adrenal Gland (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of NUP62CL Gene:

NUP62CL

SOURCE GeneReport for Unigene cluster for NUP62CL Gene:

Hs.163629

Evidence on tissue expression from TISSUES for NUP62CL Gene

  • Intestine(4.2)
  • Bone marrow(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with NUP62CL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUP62CL Gene

Orthologs for NUP62CL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUP62CL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP62CL 34 35
  • 99.28 (n)
mouse
(Mus musculus)
Mammalia Nup62cl 35
  • 30 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP62CL 35
  • 21 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 15 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 19 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 16 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nup62l 35
  • 18 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Nup62 35
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSP1 35
  • 2 (a)
ManyToMany
NUP1 35
  • 1 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for NUP62CL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP62CL Gene

ENSEMBL:
Gene Tree for NUP62CL (if available)
TreeFam:
Gene Tree for NUP62CL (if available)

Paralogs for NUP62CL Gene

Paralogs for NUP62CL Gene

(1) SIMAP similar genes for NUP62CL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NUP62CL: view

Variants for NUP62CL Gene

Sequence variations from dbSNP and Humsavar for NUP62CL Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000023506 -- 107,197,931(+) ACATA(C/T)ATTAC intron-variant
rs1000086303 -- 107,152,778(+) ATTGC(A/T)TGACT intron-variant
rs1000134532 -- 107,186,727(+) ACCCT(A/G)TCTCT intron-variant
rs1000219048 -- 107,138,513(+) AACAG(A/G)CATTT intron-variant
rs1000256268 -- 107,195,193(+) AAATT(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP62CL Gene

Variant ID Type Subtype PubMed ID
dgv2357e212 CNV loss 25503493
dgv4271n106 CNV duplication 24896259
esv1568973 CNV insertion 17803354
esv2740376 CNV deletion 23290073
esv2752312 CNV gain 17911159
nsv1153406 CNV duplication 26484159
nsv519484 CNV gain 19592680
nsv7027 CNV insertion 18451855

Variation tolerance for NUP62CL Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUP62CL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUP62CL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUP62CL Gene

Disorders for NUP62CL Gene

Relevant External Links for NUP62CL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUP62CL

No disorders were found for NUP62CL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUP62CL Gene

Publications for NUP62CL Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64

Products for NUP62CL Gene

Sources for NUP62CL Gene

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